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153
resultados
Última actualización
12/10/2025 [07:09:00]
Resultados 100 a 125 de 153
Resumen de: CN120678985A
本发明属于生物医用材料技术领域，具体涉及一种用于葡萄糖响应性DLP 3D打印胶原蛋白生物墨水、制备方法及应用。本发明提供了一种葡萄糖响应性DLP 3D打印胶原蛋白生物墨水；所述生物墨水在pH 7的生理条件下可制备具有良好的机械性能、保真度和抗降解能力的水凝胶；且该凝胶可在高血糖环境下进行响应性释放；释放的姜黄素可以清除细胞内ROS，调控巨噬细胞炎症因子表达，发挥抗氧化抗炎功效，并且凝胶材料还能够促进细胞的增殖、黏附、迁移，具有良好的生物相容性和生物活性；在为糖尿病创面治疗提供了兼具智能释药、力学适配与主动促愈功能的个性化解决方案。
Resumen de: CN120680724A
本发明提供了一种种植基台的牙冠批量打印装置及方法包括：利用牙龈形态数据库对患者牙龈采样数据进行深度优化，确定患者的基台排布特征并确定所述患者的基台打印数据，根据所述患者的已提需求和所述基台排布特征创建所述患者的若干种牙冠形态，并构建每一所述牙冠形态对应的牙冠打印数据，根据所述患者的面部数据分别模拟每一所述牙冠打印数据对应的打印效果，根据指令选取目标牙冠打印数据，根据所述基台打印数据和所述目标牙冠打印数据分别打印所述患者的基台和牙冠，根据患者的需求和实际取模结果自动调整打印设备的激光功率和打印预备工作，可以实现牙冠和基台的批量打印或个性化打印，提高了打印的效率，确保了打印成品的质量。
Resumen de: CN120682021A
本发明涉及生物医学材料的技术领域，公开了一种氧化锌‑氧化铝陶瓷骨修复支架的制备方法；首先按照比例称取氧化铝造粒粉和酚醛树脂粉体，混合氧化铝造粒粉和酚醛树脂粉体，得到获得3D打印复合粉体；其次，将3D打印复合粉体通过选择性激光烧结设备，制备得到氧化铝陶瓷坯体；将氧化铝陶瓷坯体进行干燥，得到干燥后的陶瓷坯体，并将干燥后的陶瓷坯体进行脱脂和烧结处理，冷却得到氧化铝预成型体；最后，使用纳米氧化锌溶胶对所述氧化铝预成型体进行真空压力浸渗，并引入动麦优化算法对真空压力浸渗参数进行优化，得到氧化锌‑氧化铝陶瓷骨修复支架；本发明通过制备工艺和智能优化工艺参数得到氧化锌‑氧化铝陶瓷骨修复支架，方法客观准确。
Resumen de: CN120680723A
本申请涉及一种三维模型制造物体的方法和系统。上述方法包括：获取多个待打印的三维模型，三维模型包括模型关联信息，根据模型关联信息将各三维模型存储至一个或多个存储单元中，从指定存储单元中自动抓取至少一个目标三维模型，对目标三维模型进行排版处理，得到排版结果，基于排版结果，对目标三维模型进行三维打印。采用本方法能够能够在三维模型文件设计完成后，分类存储，自动抓取数据，自动完成前处理，并自动下发至三维打印设备进行三维打印，全程无需人工任何操作，提高三维模型的打印效率。
Resumen de: KR20250138511A
본 발명은 속방출 필라멘트층 내부에 분포된 서방출 과립층을 포함하고, 상기 서방출 과립층은 아세트아미노펜(acetaminophen) 또는 이의 약학적으로 허용가능한 염 및 제1 고분자를 포함하고, 상기 속방출 필라멘트층은 이부프로펜(ibuprofen) 또는 이의 약학적으로 허용가능한 염 및 제2 고분자를 포함하며, 상기 제1 고분자는 상기 제2 고분자 보다 유리전이온도가 높은 것을 특징으로 하는 3D 프린터용 필라멘트, 이를 이용한 이중방출 제형 및 제조방법에 관한 것이다.
Resumen de: CN120665428A
本发明涉及一种光固化3D打印含碳导电多孔材料及其制备方法及应用。该方法基于巯基‑烯点击化学与聚合诱导相分离原理，通过将含巯基低聚物、含烯基低聚物、导电碳材料及致孔剂复配为低粘度墨水，通过对墨水聚合反应动力学和流变性质研究，结合光固化3D打印技术一步成型多尺度多孔结构。所述致孔剂兼具溶剂功能，降低墨水粘度并诱导微观孔隙生成，与宏观模型设计结合，形成多级孔隙网络。所得材料在智能传感、电磁屏蔽及水处理等领域展现出潜在应用价值。
Resumen de: CN120661738A
本发明提供了光固化生物墨水、数字光处理3D打印产品及其制备方法和在制备颅骨修复材料中的应用，属于生物医药技术领域。本发明提供的材料能够在不同环境条件下持续地释放H₂O₂。尤其是在模拟体内环境中，GHDP水凝胶在较长时间内保持稳定的H₂O₂释放，从而不断激活血管生成相关的信号通路，在颅骨缺损修复过程中，能够通过调控H₂O₂水平，促进新生血管形成和成骨分化，为利用氧化还原信号调控来促进组织再生提供了新的策略与思路。
Resumen de: CN120662830A
本发明提供了一种梯度致密度金属植入物增材制造方法，涉及激光选区熔化增材制造技术领域，该方法通过多模态传感器融合与自适应控制算法，实现金属植入物从外层到内层的连续梯度致密度分布，精确模拟骨骼的生物力学特性，从而省去设计多孔结构的步骤；可精确模拟人体骨骼的皮质骨(高致密)与松质骨(多孔)结构，提升植入物的生物力学适配性。
Resumen de: MX2025006182A
The present disclosure discusses techniques for securing thermoform models, including a locator plate for receiving and securing individually unique dental models having a polygon cutout, wherein the locator plate has at least one ball plunger (108) positioned within a raised polygon (102), the at least one ball plunger having a cylindrical body, a spring, and a ball extending partially outside the cylindrical body. The present disclosure also includes a system for thermoforming an orthodontic aligner and methods thereof.
Resumen de: KR20250137767A
별도의 쉘을 포함하지 않는 인공 보형물로서, 생분해성 고분자를 포함하고, 상기 인공 보형물의 외부 표면은 최대 높이 거칠기 값(Rmax)이 3~45μm이고, 상기 인공 보형물의 외부 표면은 10점 평균 거칠기 값(Rz)이 3~45μm인, 인공 보형물이 제공된다.
Resumen de: CN120661733A
本发明公开了一种3D打印构建骨肿瘤修复的压电骨支架的制备方法，属于生物医用材料领域。所述方法通过3D打印构建骨肿瘤治疗修复的压电骨支架材料，具体包括以下步骤：均匀混合固定体积比的钛酸钡(BTO)和羟基磷灰石(HA)，通过光固化树脂，打印具有特定孔隙结构的生胚，随后经过脱脂、烧结、极化和后处理，制得BTO/HA压电复合骨支架。本发明制备得到的压电复合骨支架具有与骨缺损部位高度匹配的精确形状，同时可通过压电效应催化产生活性氧自由基，实现残留骨肿瘤细胞的高效原位灭活，将骨肿瘤治疗(压电抗肿瘤)和骨缺损修复(HA促骨化)两大功能集成于一体，提升治疗修复效果，改善患者的生活质量。
Resumen de: CN120661739A
本发明公开了一种基于3D打印的可降解鼻大翼软骨支架及其制备方法，支架由PLGA以及纳米羟基磷灰石复合基体、载药微球及梯度多孔仿生结构组成，表面覆盖壳聚糖涂层以增强细胞黏附性。通过调控PLGA分子量和羟基磷灰石含量实现降解速率与软骨再生速率匹配。支架内部嵌入载有地塞米松与TGF‑β的微球。制备方法结合熔融沉积3D多喷头协同打印技术与患者CT/MRI数据建模。相较于传统不可降解材料及现有可降解支架，本发明兼具力学适应性、降解可控性、药物功能集成化及临床适配性优势，适用于先天性鼻畸形、外伤性缺损修复及联合自体软骨移植治疗，有效解决了现有材料生物相容性差、降解速率失配及通用性不足等问题。
Resumen de: CN119968177A
The present disclosure encompasses systems, compositions, and methods for use in vivo, including for enhancing soft tissue in an individual. The systems, compositions, and methods may utilize a three-dimensionally printed scaffold comprising at least a polymeric scaffold and an extracellular matrix component, including an extracellular matrix component contained on the scaffold. The polymer scaffold may include specific unit cell structures having a specific design and a pattern of alternating configurations of unit cell structures.
Resumen de: WO2025191563A1
The present invention is directed to a method for 3D printing of cells attached to a cell scaffold by simultaneous printing of a first composition comprising thermoresponsive microparticles and a second composition comprising cells. Further provided a printed 3D object such as an implant, comprising cells attached to the cell scaffold of the invention.
Resumen de: WO2025191557A1
The present invention provides a polymeric chain made of acrylate-containing imidazolidinyl urea monomers and having antimicrobial properties, a UV polymerizable resin comprising said polymeric chain, and a product such as a medical device, obtained by 3D printing of said UV polymerizable resin.
Resumen de: WO2025191493A1
Device for estimating the three-dimensional structure of teeth inside a mouth, comprising : - a central control unit, - a tray insertable inside the mouth, - a plurality of independent cameras arranged on the tray, each camera being equipped with a corresponding fixed focus lens, having a corresponding field of view and being designed to capture a corresponding image of the teeth within the field of view and to transmit the image to the central control unit, each image being composed by a plurality of pixels, and - illumination means arranged on the tray and designed to illuminate the fields of view of the cameras, wherein the central control unit is programmed to estimate the three-dimensional structure of the teeth by estimating independently for each image a depth value for each pixel thereof.
Resumen de: WO2025193110A1
The utility model relates to a chamber with a flow system for the bioprinting and culturing tissue models, containing: a chamber body (1 ) with a central opening obscured by a bottom glass (2), covered from the top by a cover (3) provided with a central opening obscured by a upper glass (5), whereby a silicone circular seal (4) is provided between the chamber body (1) and the chamber cover (3), wherein the chamber body (1) at its two opposite ends is provided with connectors (8) with connecting channels (10) providing a fluid connection to the working volume of the chamber defined by the inner walls of the chamber body (1 ) and the cover (3), the circular seal (4) and the inner surfaces of the bottom glass (2) and the upper glass (5) facing each other, where the flow system is formed by the connectors (8) with the connecting channels (10) and the working volume of the chamber contained between them; and an outer casing of the chamber comprising a bottom frame (6) and a top frame (7), wherein the chamber body (1) and the chamber cover (3), together with the elements contained between them, are enclosed between the bottom frame (6) and the top frame (7) of the outer casing, which are detachably connected to each other.
Resumen de: WO2025193112A1
The invention relates to a three-dimensional printing composition comprising a dECM hydrogel-based biomaterial, a hydrogel made of methacrylated PBS biopolymer derivatives with a radical polymerisation photoinitiator, a methacrylated chitosan solution in 1% acetic acid, neutralised to a final concentration of 3.1 mg/ml in the biomaterial, and/or a chitosan solution in 2% acetic acid, neutralised to a final concentration of 1.4 mg/ml in the biomaterial.
Resumen de: DE102024107712A1
Die Erfindung betrifft eine Vorrichtung (1) zur Herstellung von Tabletten (2), wobei die Vorrichtung (1) eine Vorläufermaterialherstellungseinrichtung (3) und eine additive Fertigungseinrichtung (4) aufweist, wobei die Vorläufermaterialherstellungseinrichtung (3) ausgebildet ist, um über einen Arzneistoff (5) verfügende Granulatpartikel (6) mit einem ein thermoplastisches Material (7) aufweisenden Beschichtungsmittel (8) zu beschichten, um Vorläufermaterialpartikel (9) zu erzeugen, und wobei die additive Fertigungseinrichtung (4) ausgebildet ist, um aus einem über eine Vielzahl von Vorläufermaterialpartikeln (9) verfügenden pulverförmigen Vorläufermaterial (10) durch selektives Lasersintern Tabletten (2) herzustellen.
Resumen de: DE102024107710A1
Die Erfindung betrifft ein Verfahren zur Herstellung von Tabletten (2), wobei dass das Verfahren einen Beschichtungsschritt und einen auf den Beschichtungsschritt folgenden additiven Fertigungsschritt aufweist, wobei im Beschichtungsschritt über einen Arzneistoff (5) verfügende Granulatpartikel (6) mit einem ein thermoplastisches Material (7) aufweisenden Beschichtungsmittel (8) beschichtet werden, um Vorläufermaterialpartikel (9) zu erzeugen und im additiven Fertigungsschritt ein selektives Lasersintern eines über eine Vielzahl von Vorläufermaterialpartikeln (9) verfügenden pulverförmigen Vorläufermaterials (10) zu Tabletten (2) durchgeführt wird.
Resumen de: US2025289909A1
Polyhydric polymers may be converted to derivatives thereof by reaction with divinyl sulfone to provide vinyl sulfone substituted polymers, where the polymers may additionally be further derivatized, including crosslinked, and the crosslinked and non-crosslinked derivatives may be used in biomedical and other applications.
Resumen de: US2025289919A1
The present disclosure provides methods, systems, devices, and kits for creating composite materials from a single resin, the composite materials having multiple continuous phases. The disclosure includes a process to three-dimensionally print objects (e.g., orthodontic appliances) with composite properties. In some aspects, the composite properties are formed from a single formulation with components that, when processed, have hard and soft continuous phases. In some aspects, the composite properties are formed by separately processing the hard phase components and the soft phase components. In some aspects, the composite materials and devices are three-dimensionally printed using the processed material.
Resumen de: US2025289921A1
The present disclosure provides photo-polymerizable components, photo-curable resins comprising one or more of such monomers, as well as polymeric materials formed from the photo-curable resins. Further provided herein are methods of producing the compositions and using the same for the fabrication of medical devices, such as orthodontic appliances.
Resumen de: US2025288524A1
Described are techniques, systems, and methods include those employing pneumatic, pressure assisted, extrusion-based 3D printing and emulsion evaporation, emulsion diffusion, nanoprecipitation, desolvation, gelation, spray-based atomization, etc. for fabricating loaded microparticles or nanoparticles that encapsulate an active pharmaceutical ingredient or live cells into a biocompatible polymer or pharmaceutical excipients. The techniques provide for encapsulation of a variety of substances including proteins, plasmid DNA, lipophilic pharmaceutical compositions, hydrophilic pharmaceutical compositions, live cells, and/or cellular components into polymeric microparticles or nanoparticles. The particles loaded with active pharmaceutical ingredients can be used for the treatment of different diseases or conditions. The particles loaded with live cells can be used for disease treatment, but can also be used for securely storing the live cells in a stable condition for transport and later use in inoculating fermentation systems, for example, to generate recombinant proteins.
Nº publicación: US2025288331A1 18/09/2025
Solicitante:
ORTHOFIX US LLC [US]
Orthofix US LLC
Resumen de: US2025288331A1
Implant systems and methods treatment of a joint include a distal portion, a middle portion, and a proximal portion. The distal portion may include a thread having a first thread minor, a first thread major, and a first pitch. The distal portion also may have a reverse cut, helical fenestration formed through the thread. The middle portion may be devoid of threads and may include a porous outer surface structure to promote bony integration, the porous outer surface structure having a leading end and a trailing end, with the leading end having a diameter larger than the first thread minor. The proximal portion may include a proximal thread having a second thread minor, a second thread major, and a second pitch. The second thread minor may be substantially the same width as the trailing end of the middle portion.
BOPI
Sede Electrónica
