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一种基于拉伸诱导的单细胞尺度载细胞生物纤维3D打印方法

Resumen de: CN122424420A

本发明涉及一种基于拉伸诱导的单细胞尺度载细胞生物纤维3D打印方法，属于组织工程技术领域。该方法通过拉伸诱导生物3D打印技术将活体细胞载入多种类型的可拉伸型活性生物墨水中，通过生物拉伸诱导打印策略，利用快速交联固化技术构建单细胞尺度载细胞纤维，经进一步结构设计打印成具有特定拓扑结构的单细胞层面微细生物组织/器官。这些微细纤维能够模拟天然细胞外基质的网络结构，为细胞提供适宜的生长环境，实现人工组织/器官构建，从而实现组织的修复和再生。

结合外泌体制剂浸润的膨体鼻成型假体设计与优化方法

Resumen de: CN122423995A

本发明属于医用高分子与组织修复材料技术领域，具体涉及结合外泌体制剂浸润的膨体鼻成型假体设计与优化方法。先采用三维建模和多喷头高精度3D打印技术制备膨体鼻成型假体；对制备的膨体鼻成型假体进行等离子体表面处理；收集脂肪干细胞培养上清液并进行离心分级和超速离心处理，得到外泌体制剂；使用外泌体制剂对膨体鼻成型假体进行浸润处理；浸润完成后对膨体鼻成型假体进行干燥处理；对获得的经外泌体制剂浸润处理的膨体鼻成型假体进行性能检测，检测结果通过反馈修正膨体鼻成型假体参数。本发明的方法通过调控膨体假体的微孔结构参数及外泌体制剂浸润条件，提高假体的亲水性与生物相容性，提升假体结构的稳定性和抗变形性能。

一种全流程数字化义齿智能制造生产方法及系统

Resumen de: CN122423980A

本发明涉及义齿智能制造技术领域，公开了一种全流程数字化义齿智能制造生产方法及系统，生产方法包括多模态口腔数据采集、数据传输和预处理、AI识别并初步设计、智能工艺规划并自动化制造、自动化后处理与个性化优化以及成品检测并追溯六个步骤，本发明相较于传统义齿生产，将生产步骤缩减到六个步骤，即可完成成品交付，缩短生产周期，减少生产工序，同时利用AI等算法辅助减少对人工的依赖程度，提高生产效率，提升成品的合格率，以解决目前行业中存在的义齿制作周期长、工序繁琐的缺陷。

一种3D打印制备GO/BG/BMP-2复合支架的方法及其应用

Resumen de: CN122424428A

本发明涉及生物医用材料技术领域，尤其涉及一种3D打印制备GO/BG/BMP‑2复合支架的方法及其应用。本发明通过以聚己内酯（PCL）为基底，掺杂合理比例的GO（氧化石墨烯）与BG（生物活性玻璃）通过3D打印制备出多孔初始支架，并通过EDC/NHS化学偶联负载BMP‑2（骨形态发生蛋白‑2）最终制备出具有网状结构的复合支架，该复合支架兼具良好的力学性能、生物相容性与高效成骨活性，不仅能够为骨缺损修复提供物理支撑和化学刺激，更能动态调控局部生物微环境（如炎症‑成骨转换），其能够通过调控EGFR、TNF‑α、RUNX2、BMP‑2等核心靶点及相关信号通路高效促进骨缺损修复。

Medicament delivery device

Resumen de: USRE50960E

0000 The present invention relates to a medicament delivery device comprising a housing (60), which housing is arranged to accommodate a medicament container (62); a drive unit (86) operably arranged to act on said medicament container (62) for expelling a dose of medicament; an activation unit (74) operably connected to said drive unit for activating said drive unit (86); said drive unit (86) comprising an actuation element (84) arranged movable inside the housing (60) from an initial position prior to activation, to a displaced position after activation; at least a first NFC-chip (170, 172) comprising specific information arranged on said actuation element; at least one shielding element (174) arranged to said housing, such as to shield said at least first NFC-chip (170, 172) from being read by an NFC-chip reader when said actuation element (84) is either in the initial position or in the displaced position. The present invention also comprises a communication system in which said medicament delivery device is a part.

椎间融合器及其制备方法

Resumen de: CN122424408A

本发明公开了一种椎间融合器及其制备方法。该制备方法包括：（1）将聚己内酯和生物活性磷酸三钙微球混合均匀，按照预设的数字模型打印获得外周骨架，所述外周骨架围合形成有空腔；（2）将胶原蛋白溶液、生物活性磷酸三钙微球和化学交联剂混合均匀得到混合浆料，灌注到所述外周骨架中，其中所述外周骨架本身的孔隙以及围合形成的所述空腔被所述混合浆料填充；再冷冻干燥，获得初步成型的椎间融合器；（3）将初步成型的椎间融合器浸入化学交联剂中，进行第二次化学交联，再冷冻干燥，得到最终产品。本发明的椎间融合器具有优异成骨活性、一体化成型且操作便捷。

一种具有3D打印条纹织构的医用金属植入物的制造方法和医用金属植入物及其用途

Resumen de: CN122425218A

本发明提供一种具有3D打印条纹织构的医用金属植入物的制造方法和医用金属植入物及其用途。所述制备方法包括以下步骤：S1：根据患者骨缺损位置解剖形态建立定制化骨植入物的三维模型；S2：定制骨植入物的金属组成和结构设计，其中，所述结构设计包括表面条纹织构间距，所述表面条纹间距为50~500μm；S3：对骨植入物的三维模型进行截面剖分并基于骨植入物的结构设计确定激光粉末床熔融打印机的激光扫描间距和层间扫描旋转角，其中，所述激光扫描间距为100~400μm，所述层间扫描旋转角为0或60°；S4：基于打印数据通过逐层送粉、激光扫描熔融的方式打印成型，得到一体化的具有3D打印条纹织构的医用金属植入物。

Systems and methods for measuring, quantifying, displaying and otherwise handling/reporting health status data and risks via self-directed health screening, information, and processing information regarding associated professional advice

Resumen de: US12685447B1

Self-directed health screening systems and methods utilizing user navigation and device integration, health analyzing algorithms, and/or self-learning techniques for the detection, quantifying, prevention, and management of health risks and discoverable health conditions. Implementations herein may include components or involve aspects associated with information collection, information processing, display/provision/rendering of professional advice, and/or processing of various associated data and information via network(s). Implementations herein provide for innovatively configured, easily upgradable, efficient, portable, scalable, easy-to-use, usage-encouraging, and/or effective implementations for screening, predicting points of inflection of pending health issues, preventing and/or managing users' health, provided via various and multiple embodiments having numerous advantages over other known techniques. Screenings, health information, and user-selectable choices may be optimized for each unit by offering different combinations over a period of time and iterating to produce the greatest usage and user traffic thereby best serving the specific health needs of the user base and sponsoring advertisers.

颌功能为导向骨水泥间置物数字化导板及制作方法

Resumen de: CN122423935A

本发明涉及口腔颌面外科颌骨缺损修复技术领域，具体公开了颌功能为导向骨水泥间置物数字化导板的设计及制作方法，其中导板包括一期协同导板组与骨松质定量填充导板；所述一期协同导板组由截骨导板、间隙维持导板、骨水泥间置物塑形导板组合构成，所述截骨导板、间隙维持导板、骨水泥间置物塑形导板对应位置开设有相互对齐且贯穿下颌骨布设的同一组固定孔洞，形成可互换装配的共用定位结构；所述骨松质定量填充导板为三面封闭、一面开放的U形槽体结构，所述骨松质定量填充导板的内腔壁面与硬化后骨水泥间置物外形形成全包式限位贴合配合。本方案以统一定位配合结构、个性化塑形限位结构、定量填充约束结构形成结构联动，提高了下颌骨缺损整体修复精度。

自操作快拆装组件用于单颗牙移动的装置及制备方法

Resumen de: CN122398486A

本发明提供自操作快拆装组件用于单颗牙移动的装置及制备方法，属于口腔正畸矫治领域。包括：快拆装组件和弓丝；快拆装组件包括目标牙快拆装件和支抗牙快拆装件；目标牙快拆装件固定于目标牙，其表面设有便于弓丝滑入的弧形表面并设有引导通道，引导通道包括连接成一体的引导区和固位区，引导区为弧形路径，固位区用于限制弓丝工作位置；支抗牙快拆装件固定于目标牙一/两侧，包括中央连接部以及翼片结构，翼片与中央连接部之间形成卡槽；弓丝一/两端设有与卡槽配合的快拆装环，弓丝末端/中部挂入目标牙快拆装件引导通道并产生弹性形变形成矫治力。实现了矫治装置的患者自操作，提高了单颗牙移动矫治效率，降低了治疗成本与医患负担。

个性化托槽粘接底板的数字化生成方法

Resumen de: CN122398484A

本发明公开了一种个性化托槽粘接底板的数字化生成方法，属于口腔正畸医疗器械数字化制造技术领域。本发明通过获取患者牙列三维数字化模型，拟合生成与牙面形态适配、厚度0.10–1.00mm的个性化底板；根据底板厚度在非粘接面保留0.05–0.95mm结构壁厚，在其余区域参数化生成蜂窝、多边形、圆形或不规则固位单元，并在固位单元侧壁开设镂空交通孔，使相邻单元相互连通；在底板与托槽主体结合区域将固位单元加深延伸并伸入托槽内部，在加深段设置多层交通孔，形成立体贯通式粘接通道；最终经数字化仿真优化与3D打印实现一体化成型。本发明实现了固位结构、交通孔、深嵌固位区域的参数化精准生成，显著提高粘接强度与密实度，减少气泡，保证结构强度与成型可靠性，可适配舌侧/唇侧个性化托槽及多种生物材料，解决传统底板固位不足、易脱落、数字化生成精度低等问题，具有高效稳定、适于规模化生产的工业实用性。

一种基于口腔暗场视觉隐身的卡环及表面电化学处理工艺

Resumen de: CN122400594A

本发明涉及口腔修复材料表面工程技术领域，解决现有技术难以兼顾固位与美观、传统氧化促骨结合理念不适用，强酸蚀孔道残留致毒问题，提供一种基于口腔暗场视觉隐身的卡环及表面电化学处理工艺，包括：先选择性激光熔化三维打印金属卡环生坯并超声清洗；再以柠檬酸钠水溶液，构建无强酸、高生物安全性的电化学体系；卡环为阳极、钛板为阴极，在室温下施加90V～110V直流恒压，处理5s～15s，通过极速电化学溶解沉积平衡，在卡环表面生成低明度目标色系的膜，可整平其微观台阶、形成耐磨抗菌层。本发明有益效果是能够兼顾卡环的固位力与美观性，实现其在口腔复合光场下的光学伪装，并兼具生物安全、耐磨及抑制细菌黏附的综合性能。

医疗设备

Resumen de: CN224505458U

本实用新型公开了一种医疗设备。医疗设备包括设备主体和打印门，设备主体包括壳体和固定支架，壳体设有安装腔和安装口，安装口与安装腔连通，安装腔内预留有打印模块的预留位，固定支架设于安装腔内；打印门与设备主体可转动地连接，打印门封闭安装口，打印门与固定支架可拆卸地连接以限制打印门转动。上述医疗设备中，打印门与固定支架可拆卸地连接以限制打印门转动，可以适配于不装配打印模块的需求，同时防止打印门在医疗设备使用过程中打开而对用户使用医疗设备造成干扰。在装配打印模块的需求下，可将打印门与固定支架拆卸，从而使打印门可以转动，打印模块安装于预留位以满足打印需求，在一定程度上方便快捷地响应用户的产品功能变更需求。

产生解剖结构的仿制品的方法和系统

Resumen de: EP3703014A1

0001 Creating a replica of an anatomical structure. At least some of the example embodiments are methods including: accepting a plurality of pictures of the anatomical structure of a subject; creating an object file that contains an initial model of an outside surface of the anatomical structure; cutting the initial model to a predetermined exterior shape circumscribing the anatomical structure, the cutting creates a positive model of the anatomical structure within the predetermined exterior shape; creating a negative model of the anatomical structure from the positive model; placing a stem tool object on an outside surface of the negative model in relationship to an orifice of the anatomical structure, and thereby creating a final negative model; printing, by way of a three-dimensional printer, the final negative model to create a negative mold; and casting the replica of the anatomical structure using the negative mold.

可植于异位组织的生物3D打印组织模拟构建体在引发心-骨交互修复中的应用

Resumen de: CN122399109A

本发明属于生物材料与组织工程技术领域，涉及可植于异位组织的生物3D打印组织模拟构建体在引发心‑骨交互修复中的应用。本发明的核心在于利用硅酸锶的离子效应调控生物功能，主动且定向地调控构建体内细胞的分泌谱，使其高效分泌SDF‑1、IGF‑1、BMP‑2等关键旁分泌因子，从而在体外共培养模型及体内心肌梗死、骨缺损动物模型中，有效引发心、骨组织间的有益双向通讯，促进异位损伤组织的修复与功能重建。

开合结构及医疗设备

Resumen de: CN224505457U

本实用新型公开了一种开合结构及医疗设备，涉及医疗器械技术领域。该开合结构包括壳体、仓体以及仓盖；仓体与壳体连接或由壳体形成，仓体设有用于容纳打印纸的容纳槽；仓盖盖设于容纳槽上，仓盖的一端转动设置于仓体的一侧上，仓盖的另一端可活动地卡接于仓体的另一侧上，以使仓盖在打开位置与关闭位置之间可转动切换；在关闭位置时，仓盖的正面与壳体的正面处于同一平面上；仓盖具有相对的第一侧壁和第二侧壁，第一侧壁和第二侧壁的外侧面上设有扣手位，扣手位显露于仓体。本实用新型改进了医疗设备的打印机构的开合结构，提高了手动开门和关门操作的便捷性，并提升了该医疗设备的整体性，降低了物料与包装成本，且运输过程中不易造成损伤。

一种内置葡萄糖传递系统的酶控制营养微球的制备方法及其应用

Resumen de: CN122398735A

本发明涉及一种内置葡萄糖传递系统的酶控制营养微球的制备方法和应用，属于营养微球的技术领域。制备方法：将水凝胶载体、葡萄糖淀粉酶AMG、交联剂溶于淀粉水溶液中，得到水相；将乳化剂和溶剂混合，得到油相；将所述水相滴入油相中并加热搅拌混合，之后置于紫外光源照射下，进行交联反应，通过高速离心去除上清液取固相，再将所得固相放入‑80℃冰箱内，预冷24 h以上；冷冻干燥得到所述内置葡萄糖传递系统的酶控制营养微球。本发明提供的营养微球可以降低高浓度葡萄糖引发的渗透压失衡的风险和改善天然多糖和合成聚合物的性能局限性。

一种适用于增材制造的高性能TC4/Fe基非晶合金复合材料及其制备方法

Resumen de: CN122406065A

本发明提供一种适用于增材制造的高性能TC4/Fe基非晶合金复合材料，以TC4和Fe基非晶合金为原料，通过增材制造工艺制备，Fe基非晶合金是Fe74Si11B10Cr2C3，复合材料中，TC4的重量百分比含量为97~99wt%，Fe基非晶合金的重量百分比含量为1~3 wt%。制备方法：制备TC4粉末和Fe基非晶合金粉末，混合均匀；在惰性气体的保护下，将混合粉末通过激光粉末床熔融工艺进行增材制造，得到钛合金块体。本发明通过在TC4钛合金基体中引入Fe基非晶合金，利用多元元素协同作用实现力学性能的显著提升，同时具备良好的增材成型性，能稳定获得高强度的增材构件，显著提升了钛合金的力学性能。

LANGUAGE-GUIDED NAVIGATION ASSISTANT FOR MEDICAL IMAGE ACQUISITION

Resumen de: US20260199024A1

Systems and methods for language-guided navigation assistance for medical image acquisition are provided. An initial image depicting a view of an image acquisition device at an initial position and a target image depicting a view of a target position are received. A trajectory between the initial position and the target position is determined based on the initial image and the target image. Text-based descriptions are generated for each step of the trajectory using a machine learning based vision-language model. One or more keyframes are selected from the trajectory based on the text-based descriptions. A particular natural language instruction for navigating the image acquisition device to a particular keyframe of the one or more keyframes to are generated. The natural language instructions are output.

CONTROLLED LOCAL MODIFICATION OF VOLUMETRIC PHYSICAL PROPERTIES

Resumen de: US20260199065A1

Manufacturing a dental part with volumetric units that vary in translucency, shading and/or color. A beam translation module of a 3D printing system is used to translate an input pattern into an output for controlling a spatial structuring of light for 3D printing an object from a resin material that is sensitive to light intensity, light color or light exposure time.

GENERATION OF INSTRUCTIONS FOR TREATMENT PLANNING USING LANGUAGE MODELS

Resumen de: US20260204413A1

A method includes obtaining treatment provider instructions expressed in natural language. The treatment provider instructions are associated with treatment of a dental patient. The method further includes providing the treatment provider instructions and a prompt including rules for a domain-specific format for dental treatment plans to a trained AI model. The method further includes obtaining, as output from the AI model, machine-readable instructions related to the treatment provider instructions structured according to the domain-specific format. The method further includes causing a treatment planning algorithm to be adjusted based on the machine-readable instructions.

LONGITUDINAL QUANTITATIVE ULTRASOUND MONITORING

Resumen de: US20260198899A1

0000 For longitudinal monitoring in quantitative ultrasound (QUS) imaging. User variability is reduced by loading the same settings from a baseline or earlier examination for a follow-up examination. Artificial intelligence (AI), given these same settings, guides placement of the field of view (FOV) and/or region of interest (ROI) in the patient for the follow-up examination. User variability is reduced, allowing for more accurate comparison between different examinations. Tools or applications using the longitudinal study may be more accurate, so the tools or applications are made more accessible on a variety of platforms rather than just the ultrasound scanner.

MACHINE LEARNING MODEL TO ESTIMATE SYSTOLIC AND DIASTOLIC BLOOD PRESSURE FROM ACQUIRED BLOOD PRESSURE DATA

Resumen de: US20260198791A1

0000 A wearable ear-mounted cardiovascular device acquires blood pressure data while applying controlled confining pressure to ear tissue and sensing arterial pulsatility with a force sensor. The waveform data are processed to extract multiple features from inflation, deflation, compression, and decompression segments, including pressures at characteristic changes in oscillation trend, oscillation amplitudes, frequency-domain descriptors, and waveform-derived statistics. Separate machine learning regression models, such as Support Vector Machines, use distinct feature sets to estimate systolic and diastolic blood pressure relative to reference arm cuff measurements. The trained models provide real-time, cuffless blood pressure values from the ear device, and can operate with stepwise compression or in a passive ear-clip configuration calibrated intermittently using external blood pressure devices.

SYSTEMS AND METHODS FOR FABRICATING HYDROGELS WITH INTRINSIC VASCULAR CHANNELS FOR LIVER TISSUE ENGINEERING

Resumen de: US20260199559A1

0000 Disclosed are implantable devices, systems, and methods of fabricating, testing, optimizing, and/or implanting such devices. An implantable device includes a body, a first intrinsic channel network formed in the body and configured to receive cells, and a second intrinsic channel network formed in the body and configured to allow for active flow of a fluid to support viability and/or function of the cells in the first intrinsic channel network. The first intrinsic channel network comprises a first channel and the second intrinsic channel network comprises a second channel, with at least segments of the first and second channels parallel to and spaced apart from each other. Cells may be suspended in a collagen matrix and introduced to the first intrinsic channel network.

MOISTURE CHAMBER ADAPTED FOR USE WITH EYEGLASSES

Nº publicación: AU2025286486A1 16/07/2026

Solicitante:

BRITER EYEZ LLC
BRITER EYEZ LLC

Resumen de: AU2025286486A1

A moisture chamber adapted for use with eyeglasses. The moisture chamber is a single-use, disposable, component that is temporarily adhered to the inside of a the lens of a pair of glasses. The moisture chamber may be used on one or both of the lenses and works by creating a moist environment for the eye to help alleviate dry eyes. The moisture chamber may be made of silicon and may be 3-D printed.