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一种半互穿聚合物网络及其制备方法和应用

Resumen de: CN121313915A

本发明涉及血管闭合装置技术领域，具体是一种半互穿聚合物网络及其制备方法和应用。所述半互穿聚合物网络由功能化的聚醚和聚酯共混后，通过光交联制备得到；且具粘附功能基团以及光交联功能基团。本发明将形状记忆分子开关与粘附功能基团通过互穿网络结构设计集成到一种材料中，利用光交联实现材料3D打印和原位交联的协同，提升打印装置的结构稳定性和形状记忆性能，实现了血管闭合装置的智能自部署和稳定粘附封堵。

用于设计对象的系统和方法

Resumen de: US2024342995A1

Systems and methods for designing additively manufactured objects are provided. In some embodiments, a method includes receiving a treatment plan for a patient's teeth, and determining a set of appliance parameters for a dental appliance configured to implement the treatment plan. The method can also include determining a set of manufacturing parameters for a fabrication system to be used to additively manufacture the dental appliance. The method can further include generating a 3D digital representation of an appliance geometry for the dental appliance. The appliance geometry can be configured to mitigate loss of fidelity at a target region of the dental appliance due to at least one manufacturing parameter of the fabrication system.

牙颌模型

Resumen de: CN223787727U

本实用新型公开一种牙颌模型，用作热压膜成型制作壳状牙齿矫治器的模具，包括牙颌模型本体，牙颌模型本体的两侧后牙区分别设有向对颌方向延伸的重定位颌元件；重定位颌元件包括分体设置的由第一材料制作的固定部和由第二材料制作的主体部，主体部与固定部以可拆卸方式连接；固定部与牙颌模型本体的一侧表面固定连接，固定部朝向主体部的一侧设置有第一连接部；主体部设置有与第一连接部匹配且沿颊舌向可拆卸安装的第二连接部。

一种基于金纳米夹层的表面合金微孔化方法及医用植入件

Resumen de: CN121295105A

本发明属于表面处理技术领域，公开了一种基于金纳米夹层的表面合金微孔化方法及医用植入件。所述方法包括：获取原工件；于所述原工件表面沉积一金薄膜以形成一中间工件；将所述中间工件置于等离子真空炉内；其中，加热台、活性屏与顶盖合围形成一空心阴极；所述活性屏及所述顶盖的材质均为靶材，中间工件则置于所述空心阴极内；对等离子真空炉依次抽真空、通入惰性气体后，打开直流脉冲电源进行等离子辉光放电，进而使来自靶材的等离子体对金薄膜进行轰击，并于中间工件表面形成第一合金簇及第二合金簇，第一合金簇与第二合金簇继续互相扩散以于原工件表面形成一具有微孔结构的表面合金层。本发明满足了医用植入件对表面合金化处理的应用需求。

具有多个曲率的弹性密封形成结构

Resumen de: EP4674457A2

The present invention relates to a patient interface for sealed delivery of a flow of air at a continuously positive pressure with respect to ambient air pressure to an entrance to a patient's airways including at least an entrance of a patient's nares. The patient interface is configured to maintain a therapy pressure in a range of about 4 cmH2O to about 30 cmH2O above ambient air pressure in use, throughout a patient's respiratory cycle, while the patient is sleeping, to ameliorate sleep disordered breathing. The patient interface comprises a plenum chamber at least partially forming a cavity pressurisable to a therapeutic pressure of at least 6 cmH2O above ambient air pressure. The plenum chamber includes a plenum chamber inlet port sized and structured to receive the flow of air at the therapeutic pressure for breathing by a patient. The patient interface further comprises a seal-forming structure having a textile membrane constructed and arranged to form a seal with a region of the patient's face surrounding the entrance to the patient's airways inferior to a nasal bridge region of the patient's face. Said textile membrane has at least one hole such that the flow of air at said therapeutic pressure is delivered to at least the entrance to the patient's nares. The seal-forming structure is constructed and arranged to maintain said therapeutic pressure in the cavity throughout the patient's respiratory cycle in use. The textile membrane comprises a first layer constructed

一种增材制造的生物型胫骨托假体及其制作方法

Resumen de: CN121287371A

本发明一种增材制造的生物型胫骨托假体及其制作方法，涉及一种人工膝关节假体技术领域。生物型胫骨托假体包括四种类型：生物型对称胫骨托、生物型对称无柄胫骨托、生物型解剖型胫骨托和生物型解剖型无柄胫骨托。假体主要由托体、多孔结构和堵销等组件构成，通过增材制造技术一体成型，确保精度和强度。多孔结构设计为非规则空间立体网格状，厚度为0.6‑1.6mm，用于促进骨小梁长入，实现生物固定。定位钉采用子弹头形设计，配有排气槽和缺口，简化安装并增强稳定性。制作方法包括设计建模、应力优化、增材制造及后处理步骤，假体采用钛合金材料，满足相关国际标准。本发明具有安装简易、固定可靠、骨长入效果好等优点。

一种用于屈光不正医学研究的小鼠头架构建方法及小鼠头架结构及其安装使用方法

Resumen de: CN121287355A

本发明涉及一种用于屈光不正医学研究的小鼠头架构建方法及小鼠头架结构及其安装使用方法，首先获取小鼠头颈部三维解剖学数据；基于该数据设计头部安装架和眼部实验架的三维模型，并采用增材制造工艺成型。小鼠头架包括头部安装架和眼部实验架，头部安装架设有头部夹孔和颈部套口；眼部实验架设有镜片支架，并连接头部安装架。将头部安装架套接于小鼠头颈部并用绳索固定；将屈光实验镜压入镜片支架中；可在维持头架固定的状态下，拆卸实验镜并通过实验通孔对眼部用药。本发明旨在克服目前的屈光不正实验研究中动物模型造模装置固定方式存在的创伤性大、操作复杂、稳定性差且难以配合眼部用药的技术难题。

基于多重涂覆和UV固化工艺的组织黏附型软骨化双层人工耳廓材料及其制备方法

Resumen de: CN121288005A

本发明公开了一种基于多重涂覆与UV固化工艺的组织黏附型软骨化双层人工耳廓材料及其制备方法。方法包括：1）采用微流控‑浸渍技术制备负载Kartogenin的甲基丙烯酸化透明质酸（HAMA）微球；2）通过甲基丙烯酰化及羧酰亚胺偶合反应，合成兼具多巴胺功能与光交联能力的双改性HAMA‑DA；3）基于LiDAR与三维重建技术，通过光固化3D打印制备高保真人工耳廓模具；4）配制复合间充质干细胞与载药HAMA微球的甲基丙烯酸化明胶（GelMA）复合浆料；5）在模具表面依次多重涂覆丙三醇层、HAMA‑DA溶液层、GelMA复合浆料层和HAMA‑DA溶液层，过程中配合UV预固化和二次UV固化，制得具备湿态组织黏附性与软骨诱导潜能的双层耳廓结构。该体系为人工耳廓构建提供了先进的材料平台与工艺路径。

一种3D打印件微孔表面制造工艺及3D打印件

Resumen de: CN121295114A

本发明提出一种3D打印件微孔表面制造工艺及3D打印件，涉及表面处理领域；工艺包括：将3D打印件置于源极靶材制成的外罩内部构成空心阴极后整体置于直流脉冲等离子真空炉内，真空炉顶部设置有电源正极，外罩作为活性屏；在直流脉冲电源作用下放电启辉，并在活性屏和空心阴极效应增强下将源极靶材通过等离子形式轰击至高温的3D打印件表面，以便通过吸附和互扩散方式在3D打印件表面形成均匀分布的微孔结构和表面合金层。方案利用活性屏耦合空心阴极技术获得高密度、活性的等离子与高温的3D打印件表面碰撞实现离子的互扩散合金化，不仅将表面未充分熔合的粉末颗粒再次熔合，解决致敏问题，且在打印件表面获得微孔结构。

一种颌骨囊肿的根管冲洗治疗系统及制备方法

Resumen de: CN121287334A

本发明公开了一种颌骨囊肿的根管冲洗治疗系统及制备方法，颌骨囊肿的根管冲洗治疗系统包括冲洗治疗器，根管冲洗治疗系统包括用于嵌设在病牙内部的嵌设体，嵌设体包括固定部和与固定部连接的导向部；牙髓腔与根管通道连通。固定部用于嵌设在病牙的牙根部开设的根管通道上，固定部内形成有第一腔体，导向部内形成有第二腔体，第一腔体和第二腔体连通；导向部上开设有导向通孔，导向通孔与第二腔体连通，固定部与颌骨囊肿接触，以使冲洗治疗器穿过导向通孔、第二腔体和第一腔体与颌骨囊肿接触。本发明的有益效果是：冲洗治疗器穿过导向通孔可以直接作用于颌骨囊肿腔，避免在颌骨的其他位置开辟新的冲洗通路而造成损伤，冲洗治疗器穿过导向通孔，冲洗和给药目标明确，效率极高。

包含可生物降解聚合物的植入物、其制造方法及其组合物

Resumen de: TW202506210A

Provided is an implant, which comprises a first biodegradable polymer and a second biodegradable polymer, wherein the first biodegradable polymer comprises a copolymeric polyhydroxyalkanoate (PHA), and the copolymeric polyhydroxyalkanoate (PHA) comprises a repeat unit derived from 4-hydroxybutyrate (4-HB) in an amount of 0.1% by weight to 50% by weight based on the total weight of the copolymeric polyhydroxyalkanoate (PHA).

一种淀粉-壳聚糖复合凝胶材料及其制备方法和应用

Resumen de: CN121287922A

本发明属于功能性凝胶材料技术领域，公开了一种淀粉‑壳聚糖复合凝胶材料及其制备方法和应用。方法一：将氧化淀粉和矿物质离子溶液混合均匀，进行糊化处理，制得凝胶化浆料，所述凝胶化浆料中还含有壳聚糖；将所述凝胶化浆料进行热挤压3D打印，制得具有三维结构的淀粉‑壳聚糖复合凝胶材料；方法二：将氧化淀粉和矿物质离子溶液混合，进行糊化处理，制得凝胶化浆料；并配制壳聚糖浆料；将两种浆料通过双喷头交替进行热挤压3D打印，制得具有多层交替结构的淀粉‑壳聚糖复合凝胶材料。本发明工艺简单可控，制得的复合凝胶具有优异的胃部稳定性和肠道靶向性，能同步激活小肠细胞旁途径和结肠跨细胞途径双重吸收机制，显著提高镁的生物利用度。

3D PRINTED CITRATE-BASED SCAFFOLDS USING ADDITIVE TO IMPROVE PRINTABILITY

Resumen de: WO2026011060A1

A citrate composition is provided for use in 3D printing of end products, e.g., scaffolds. The disclosed composition incorporates water soluble salts and/or sugars into a pre-polymer to improve the viscosity for 3D printing, increase the porosity of the resulting scaffold, and improve the handling of the citrate based bioceramic compositions.

CURABLE FORMULATIONS USABLE IN FORMING TRANSPARENT MATERIALS OR OBJECTS FEATURING HIGH MECHANICAL STRENGTH

Resumen de: WO2026009143A1

Curable formulations that provide, when hardened, transparent materials, and uses thereof, are provided. The curable formulations include two or more urethane (meth)acrylate materials which differ from one another at least by the number average molecular weight lower than 2000 grams/mol and/or the Tg, and optionally by the number of blocks and/or the NCO/OH ratio in the urethane (meth)acrylate material, and optionally a material or substance that is capable of interfering with the formation of micron-sized clusters in a hardened material formed of the formulations.

CHEAP, PORTABLE, ELECTRICITY-FREE ELECTROPORATOR FOR GENE TRANSFER IN CELLS

Resumen de: WO2026010589A1

The invention is a cheap, portable, electricity-free electroporator for gene transfer in single cells. In order to transfer substances such as the gene DNA in cells, it generates electricity in during 20 microseconds in the range of about 200 volts to 5 kv. This causes a temporary opening of the cell pore in bacteria/cells and the targeted substance enters. The first part of the product: Cuvette holder: It is designed to hold the current electroporation cuvettes in a suitable size. The 2 copper connection cables from the piezoelectricity supply electricity to the cuvette. The second part of the product: Main case: It contains the 1st part of the product and also contains the piezoelectric system, cables, and button. It weighs approximately 30 grams and is a 3D printed single piece. Its dimensions are preferably 27 mm x 62 mm x 35 mm. The third part of the product: Button: Thanks to this button, electricity through piezo system is transferred to the cuvette with a single press.

DENTAL PROSTHESIS OR TEETH-STRAIGHTENING DEVICE CONTINUOUS PRODUCTION PROCESS USING 3D PRINTER, AND DENTAL PROSTHESIS OR TEETH-STRAIGHTENING DEVICE MANUFACTURED USING CONTINUOUS PRODUCTION PROCESS

Resumen de: WO2026010233A1

The present invention relates to a dental prosthesis or teeth-straightening device continuous production process using a 3D printer, and to a dental prosthesis or a teeth-straightening device manufactured using the continuous production process. The present invention is for manufacturing a patient-customized dental prosthesis or teeth-straightening device by using 3D data on the oral structure of a patient, wherein a teeth-straightening device is manufactured using 3D printing, supporter separation, washing, post-curing, and heat treatment processes are performed in a continuous process, and the steps proceed by means of a robot without manual handling by a person during proceeding of the steps, thereby improving production efficiency and enabling defective products to be sorted out without additional equipment.

3D Printed Citrate-Based Scaffolds Using Additive to Improve Printability

Resumen de: US20260008884A1

A citrate composition is provided for use in 3D printing of end products, e.g., scaffolds. The disclosed composition incorporates water soluble salts and/or sugars into a pre-polymer to improve the viscosity for 3D printing, increase the porosity of the resulting scaffold, and improve the handling of the citrate based bioceramic compositions.

Implantable objects fabricated by additive manufacturing and methods of fabricating the same

Resumen de: AU2025275151A1

An implantable object 1000’ and a method 100 of fabricating an implantable object is disclosed. The method 100 comprises melting a powder 210 comprising at least nickel and titanium with an energy source 220 and iteratively forming a plurality of stacked metallic layers 330 from the melted powder using an additive manufacturing technique. The implantable object is biased to expand from a first configuration 501 to a second configuration 502 when at or above a transformation temperature. ec e c

A METHOD FOR DESIGNING AN ARTIFICIAL JOINT IMPLANT AND CORRESPONDING BROACHING AND OSTEOTOMY GUIDE APPARATUSES AND A DIGITAL IMPLANT PLATFORM THEREOF

Resumen de: US20260007520A1

The present invention relates to a method for interactively designing via an implant design platform an artificial joint implant for hip arthroplasty and corresponding broaching and osteotomy guide apparatuses. The proposed implant design platform reconstructs the anatomy of the patient's pelvic and femoral bones in a 3D digital environment, and accordingly develops a patient-specific femoral implant stem as well as patient-specific surgical tools broach/rasp, osteotomy guide) used in total 10 hip arthroplasty. The patient-specific femoral implant stem developed may be optimized to ensure optimum mechanical performance for the patient, employing complex internal lattices that minimize stress shielding and advanced trabecular surfaces to promote osseointegration.

3D PRINTED METAL CORPECTOMY DEVICE WITH STRUCTURAL AND ENDPLATE LATTICE STRUCTURES

Resumen de: US20260007525A1

A corpectomy implant device having a solid portion, structural volume and porous end plates configured is disclosed. In some embodiments, the corpectomy device comprises a stochastic lattice structure in the structural volume of the device to reduce stiffness and improve radiolucency. In some embodiments, the porous endplates comprise a lattice configured to provide porosity for bone ingrowth. In some embodiments, endplates are configured to facilitate insertion of the implant between the adjacent vertebrae and to provide anchoring of the corpectomy device to and prevent migration of the device implant in an installed state.

COMPOSITIONS AND METHODS FOR TREATING DIABETES

Resumen de: US20260007805A1

Aspects of the disclosure include an implantable composition/medical device encapsulating insulin-producing cells for use in the treatment and management of diabetes, generally comprising a multilayer lattice structure fabricated from a continuously bioprinted cell-laden core/shell fiber, the lattice structure having a defined infill density and at least coating applied to the lattice post-printing, and preferably at least one conformal coating. In this way, multilayer lattice structures are provided with improved stability, retrievability, and functionality.

3D PRINTED BIOACTIVE SCAFFOLDS

Resumen de: US20260007806A1

Provided is an implantable tissue scaffold comprising a mixture of a biocompatible organic polymer and chitin, wherein the chitin is embedded in the biocompatible organic polymer. Also provided is a composition for 3D printing, the composition comprising at least one biocompatible organic polymer and chitin that may be partially deacetylated, wherein the chitin is embedded within the biocompatible organic polymer. Further provided is a method of promoting tissue formation, comprising implanting a tissue scaffold comprising a mixture of a biocompatible organic polymer and chitin at a site in need of regenerative bone tissue formation.

3D PRINTING DEVICE, 3D PRINTING METHOD AND 3D TUBULAR OBJECTS OBTAINED BY SAID METHOD

Resumen de: US20260008228A1

A 3D printing method for manufacturing a 3D tubular object includes creating successive layers of polymerized resin. Each layer is created by providing, on an external surface of a build platform, a fluid resin which is polymerizable by electromagnetic radiation. A beam of electromagnetic radiation suitable for polymerizing the fluid resin is positioned, according to a printing model, towards the external surface of the build platform, creating the layer of polymerized resin. The build platform includes a stem having a longitudinal axis, and forming a tubular shaped surface around the longitudinal axis, so that the external surface of the build platform is included in the tubular shaped surface. The beam is variably positioned according to the printing model to impinge on different points of the fluid resin. The 3D tubular object is obtained by removing from the stem a 3D object formed by the successive layers of polymerized resin.

BIOPRINTING METHODS AND SYSTEMS

Resumen de: MX2025010283A

In a bioprinting system and method, a bioprinter may include one or more reservoirs, a printhead, and a print surface on which the bioprinting is dispensed. An optical system may collect imaging data of a plurality of cells within a cross-linkable material before, during and/or after passage of the plurality of cells through the bioprinting system. A computing system may process the imaging data to determine a quantity, distribution, concentration, and/or morphology of the plurality of cells. A machine learning system compares characteristics of the plurality of cells before, during and/or after passage of the plurality of cells through the bioprinting system to user-established cell morphologies corresponding to physical properties of cells and/or cell aggregates within a predetermined tolerance. Additionally or alternatively, the machine learning system compares characteristics of the plurality of cells at one stage in the bioprinting system to characteristics of the plurality of cells at another stage in the bioprinting system.

NOZZLE PLATE, FLUID EJECTION HEAD, FLUID EJECTION DEVICE, AND MODIFYING METHOD OF NOZZLE PLATE

Nº publicación: EP4674624A1 07/01/2026

Solicitante:

BRADY WORLDWIDE INC [US]
Brady Worldwide, Inc

Resumen de: EP4674624A1

A nozzle plate (128) configured for a fluid ejection head (114), a fluid ejection head (114) containing the nozzle plate (128), a fluid ejection device (100) containing the fluid ejection head (114), and a method for modifying a nozzle plate (128) for a fluid ejection device (100) to reduce fluid flooding thereon are provided. The nozzle plate (128) includes a plurality of nozzle holes (126) therein, the nozzle plate (128) being attached to a flow feature layer (124) on a semiconductor substrate (116), and the nozzle plate (128) includes a first hydrophobic region (150, 176, 186) surrounding each of the plurality of nozzle holes (126), whereby the first hydrophobic region (150, 176, 186) is configured to reduce flooding of the nozzle plate (128).