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一种基于甲基丙烯酰化明胶的微球、其制备方法及其在生物墨水中的应用

Resumen de: CN121588283A

本发明公开了一种基于甲基丙烯酰化明胶的微球、其制备方法及其在生物墨水中的应用，该微球以甲基丙烯酰化明胶为核心基材，可选择性复合糖胺聚糖‑甲基丙烯酰化明胶和/或脂质体，通过微流控技术制备而成，所得微球尺寸均一，且复合组分可赋予微球优异的自粘附特性；进一步采用微流控技术，以基材及复合组分作为微球壳相、细胞分散液作为微球核相，制备具有核壳结构的载细胞微球，该载细胞微球能良好维持包埋细胞的正常存活与生长。基于甲基丙烯酰化明胶的微球或载细胞的基于甲基丙烯酰化明胶的微球，可作为3D打印墨水用于制备支架材料、载细胞支架材料，适配细胞三维培养、细胞球培养、高密度细胞培养及组织工程植入材料领域。

包括整体式模具主体的牙体修复模具

Resumen de: WO2025027496A1

A custom tool for forming a dental restoration in a mouth of a patient includes a one-piece mold body providing for a customized fit with at least one tooth of the patient, the one-piece mold body including an occlusal portion forming an occlusal surface corresponding with an occlusal surface of the tooth, a mesial proximal portion forming a mesial proximal surface corresponding with a mesial proximal surface of the tooth, and a distal proximal portion forming a distal proximal surface corresponding with a distal proximal surface of the tooth. The mold body is configured to combine with the tooth of the patient to form a mold cavity encompassing missing tooth structure of the tooth. The occlusal portion, the mesial proximal portion, and the distal proximal portion are based on three-dimensional scan data of the mouth of the patient.

一种3D打印用的医用级PEEK复合材料及其制备方法

Resumen de: CN121592153A

本发明公开了一种3D打印用的医用级PEEK复合材料及其制备方法，涉及3D打印技术领域，解决了现有PEEK材料存在的生物活性低的问题。该医用级PEEK复合材料由以下重量份的原料制成：聚醚醚酮基体80～95份、生物活性填料5～15份、界面改性剂0.5～5份、导热与成核增强剂0.1～3份；所述生物活性填料包括重量比为（1～5）:（5～1）的纳米羟基磷灰石和生物活性玻璃。能够有效模拟天然骨环境，提高复合材料的生物活性，促进细胞黏附与增值，从而提高细胞增值率，还能有效提高了复合材料的抑菌效果和力学性能。

一种用于挤出3D打印的光-酸协同增强生物墨水及其制备方法

Resumen de: CN121592122A

本发明公开了一种用于挤出3D打印的光‑酸协同增强生物墨水及其制备方法。该墨水由N‑乙烯基吡咯烷酮（NVP）、聚乙烯醇（PVA）、光引发剂及具有“单羟基‑双羧基”特异结构的苹果酸组成。打印时，墨水经挤出并结合紫外光照射实现初步定型，随后在加热油性支撑浴中同步触发酸催化NVP深度聚合及PVA微晶化，一步完成光固化定型与热处理增强。本发明利用苹果酸独特的分子结构构建了高效的光‑酸协同增强机制，不仅显著提升了单体转化率，更通过物理‑化学双网络大幅增强了打印体的力学强度与形状保真度，有效解决了生物墨水可打印性与强度的矛盾，在组织工程、柔性电子等领域具有广阔应用前景。

一种基于直接3D打印的无托槽隐形矫治器及其数字化设计与制造方法

Resumen de: CN121572585A

本发明公开了一种基于直接3D打印的无托槽隐形矫治器及其数字化设计与制造方法。该方法构建了一个数字化闭环流程：首先通过口内扫描与数字化排牙设定矫治目标；继而利用收缩包裹算法构建矫治器光滑包络空间；采用基于PointNet++的AI技术精准分割牙冠以界定力边界；通过厚度控制与边缘优化算法生成形态精确、力学稳定的矫治器数字模型；最后，基于DLP技术使用生物相容性树脂直接打印矫治器，并经过严格的二次固化等后处理确保其性能与安全。本发明省去了传统压膜工艺，从根本上消除了累积误差，并能通过工艺控制实现矫治器力学性能的个性化梯度设计，标志着隐形矫治技术从“形态匹配”迈向“功能适配”。

辅助器打印方法、装置、电子设备、存储介质及计算机程序产品

Resumen de: CN120770988A

The invention discloses an artificial limb printing method and device, electronic equipment, a storage medium and a computer program product.The method comprises the steps that a first physiological data set of a first user is obtained; calling a first artificial intelligence model to process the first physiological data set to obtain a first constraint parameter set; the first artificial intelligence model is used for recommending a constraint parameter group based on an input physiological data group; the constraint parameter set represents constraints related to the mechanical performance requirements corresponding to the input physiological data set; taking the first constraint parameter group as a constraint, and calling a generative design algorithm to process the first physiological data group to obtain a first design parameter group; the generative design algorithm is used for generating a design parameter group meeting the corresponding comfort requirement on the basis of the input physiological data group, and the design parameter group comprises a plurality of design parameters of the artificial limb; and generating a first file based on the first design parameter group and the slice parameter group, and outputting the first file to the three-dimensional printing device.

数字化可无线传输的3D打印支具多参数监测系统及方法

Resumen de: CN121572596A

本申请涉及医疗器械与智能健康监测技术领域，公开了一种数字化可无线传输的3D打印支具多参数监测系统及方法，旨在解决刚性支具与柔性传感器因弹性模量差异大而导致的界面应力集中、传感器易脱落及信号精度差的问题。该系统通过3D打印在支具内表面构建梯度互锁界面结构，并原位成型柔性多参数传感阵列，实现刚柔一体化；还包括嵌入式数据采集处理单元、无线传输模块及微型能源模块。该方法包括三维建模分区、梯度界面路径生成、多材料协同打印、信号同步采集融合及无线传输。本发明显著提升界面结合强度与监测精度，简化制造流程，支持个性化定制。

一种蜂窝状刚性-柔性两相颗粒及其在光固化3d打印树脂中的应用

Resumen de: CN121574311A

本发明公开了一种蜂窝状刚性‑柔性两相颗粒及其在光固化3d打印树脂中的应用。该蜂窝状刚性‑柔性两相颗粒包括柔性聚氨酯相和刚性氧化硅相。制备步骤S1、制备包含聚氨酯颗粒的乳液作为种子乳液（乳液A）；S2、制备包含氧化硅前体和引发剂的乳液（乳液B）；S3、将乳液B加入到乳液A中，混合均匀得到混合液；S4、在施加动态作用和无氧条件下，将混合液升温至60‑80℃反应20～24h，得到含有蜂窝状刚性‑柔性两相颗粒的乳液。将含有蜂窝状刚性‑柔性两相颗粒的乳液加入到具有光固化性能的可降解聚合物材料中能同时提升聚合物材料的韧性和强度，且不影响聚合物的光固化性能和生物相容性；适用于作为填料添加到高精度光固化3d打印制备的各类成型制品。

一种种植模型3D打印树脂材料及其应用

Resumen de: CN121570635A

本发明公开了一种种植模型3D打印树脂材料，包含如下按重量份计的原料组分：聚氨酯丙烯酸酯低聚物30‑50份；单官能团活性稀释剂30‑40份；双官能团活性稀释剂20‑40份；光引发剂1‑3份；流平剂0.1‑3份；消泡剂0.1‑3份；填料0.5‑3份；耐刮蜡0.5‑3份；颜料0.2‑0.5份；聚氨酯丙烯酸酯低聚物与活性稀释剂的质量比为（0‑1）：1；所述单官能团活性稀释剂和双官能团活性稀释剂的质量比为（1‑1.5）：1。该树脂材料通过引入聚氨酯丙烯酸酯体系，改善后的光敏树脂通过3D打印制造的种植牙模，具有高下机精度、高逆扫尺寸稳定性、高性价比，应用于口腔医学领域。

一种负泊松比结构多功能血管支架及其制备方法

Resumen de: CN121571655A

本发明公开了一种负泊松比结构多功能血管支架及其制备方法，涉及医疗器械技术领域，包括负泊松比结构的血管支架模型的构建、选区激光熔化增材制造、化学抛光处理以及表面仿生改性处理。该支架利用负泊松比特性能够更好地适应血管的变形，减少因变形不同步产生的不相容性，其结构圆润平滑，可有效避免传统支架锐利拐角处易产生的血流湍流与涡流，改善血流动力学性能，降低血小板激活与血栓形成的风险，通过制备表面梯度涂层，实现多机制协同，有利于支架表面内皮层的形成。

増強又は骨充填のための部分的な骨梁要素

Resumen de: AU2023303676A1

Element (100, 200, 300) for augment or bone filler, comprising at least one first outer-layer portion (101) having a trabecular lattice of metallic material, and further comprising at least one reinforcing inner layer (103) of metallic material having a plurality of channel structures (104) arrayed with respective channel openings (105) delimited by edges in structural contact with the at least one first outer-layer portion (101).

一种颈椎单开门手术3D打印导板的制作方法

Resumen de: CN121572598A

本发明公开了一种颈椎单开门手术3D打印导板的制作方法，涉涉及医疗辅助器械与增材制造交叉技术领域，先获颈椎CT数据三维重建骨骼模型，虚拟规划手术方案，再参数化生成导航模板数字化原型，经有限元仿真优化，用光固化设备以生物相容性树脂打印，最后处理得终产品。本发明通过CT薄层扫描与三维重建生成高精度颈椎骨骼模型，经虚拟规划确定铰链区、开门槽线及钉道参数，解决传统手术依赖经验易致损伤或定位偏差问题；再以特定算法构导航模板贴附曲面并留软组织补偿间隙，配镂空窗凸起限磨钻深度，同时经有限元仿真与拓扑优化控导板变形，选特定树脂保稳定性，借虚拟配准与标准化制造保适配性，提升手术精准安全与效率。

一种基于3D打印的双层载药植入体及其制备方法与应用

Resumen de: CN121570412A

本发明属于药物共递送技术领域，具体涉及一种基于3D打印的双层载药植入体及其制备方法与应用。本发明通过合成明胶甲基丙烯酸酯GelMA；制备2‑氨基葡萄糖修饰的奥沙利铂Oxa‑2‑DG；MExo的提取与纯化；GelMA的3D打印与AI优化最终制备获得具有双层结构的载药植入体LEH@OG。本发明制备的共递送平台可在腹腔内降解，实现内外层药物的序贯释放，具有较高的生物安全性，对各组织脏器均无明显损伤。并表现出强大的抗肿瘤疗效和免疫激活作用。

一种具有生物相容性的低粘度树脂组合物及其制备方法和应用

Resumen de: CN121574312A

本发明提供了一种具有生物相容性的低粘度树脂组合物及其制备方法和应用，涉及临时牙冠树脂材料的技术领域。所述具有生物相容性的低粘度树脂组合物按重量份数计包括：丙烯酸酯树脂10~40份、活性稀释剂30~60份、改性填料10~50份、光引发剂0.5~2.5份、助剂0.5~5份；所述改性填料为钛酸酯偶联剂改性纳米填料，且所述钛酸酯偶联剂改性纳米填料包括纳米填料内核、以及包覆于所述纳米填料内核的表面的单分子钛酸酯偶联剂包覆层。本发明提供的临时牙冠用树脂组合物的粘度较低，流动性优异，利于材料打印成型；同时，保证了所制备的材料具有较好的生物相容性以及力学强度。

セラミックベニア及びセラミックベニアを作製する連続付加製造

Resumen de: CN120857914A

The present disclosure provides a method of making a ceramic article. The method comprises (a) obtaining a photopolymerizable slurry or sol comprising a plurality of ceramic particles distributed in the photopolymerizable slurry or sol, and (b) continuously moving a build substrate through the photopolymerizable slurry or sol using actinic radiation, and selectively polymerizing the photopolymerizable slurry or sol to form a gelled article. The method further includes (c) extracting a solvent from the gelled article to form an aerogel article or a xerogel article; (d) heat treating the aerogel article or the xerogel article to form a porous ceramic article; and (e) sintering the porous ceramic article to form a sintered ceramic article. The sintered ceramic article exhibits a specific density. In addition, additive manufactured ceramic articles exhibiting specific density, opacity, or both are provided.

SYSTEM, METHOD AND APPARATUS FOR PERSONALIZED DENTAL PROSTHESES PLANNING

Resumen de: US20260053603A1

Methods, systems, and techniques for collecting data for use in designing a personalized dental prosthesis for a patient. At least one camera is used to obtain a series of two-dimensional photos or a three-dimensional model of a head and face of the patient. At least one machine learning model is used to determine facial or oral landmarks and a central incisal edge of the prosthesis from the photos or model. Dimensions for the dental prosthesis are determined form the landmarks and central incisal edge. The dimensions include a labial border of the prosthesis, distal borders of the prosthesis, a superior border of the prosthesis, an inferior border of the prosthesis, a lingual border of the prosthesis, and buccal borders of the prosthesis. The dimensions are output to an output file for use in manufacturing the prosthesis.

SOCKET FORMING TOOLS FOR AUTOTRANSPLANTATION

Resumen de: US20260053600A1

A socket preparation tool configured to facilitate autotransplantation of a donor tooth to a recipient site is provided. The socket preparation tool includes a tooth replica of the donor tooth. A coronal portion is optionally included for facilitating alignment of the tooth replica adjacent teeth during a simulated autotransplantation. A radicular portion includes a smooth surface configured to facilitate compression of soft bone or soft tissue of the tooth replica or a contoured surface adapted for filing or cutting bone of the tooth replica. A cylindrical attachment is configured to be coupled to the tooth replica, such as via a receiver. A method of guided autotransplantation of a donor tooth via the customized socket preparation tool includes at least fitting and adjusting the socket preparation tool coupled to the tooth replica in the recipient site, before extracting the donor tooth.

METHOD OF ASSEMBLING A BIOREACTOR HAVING A BIOLOGICAL MATERIAL DEPOSITING END THAT IS MOVABLE WITH THE TOP PORTION TO ALLOW BIOPRINTING

Resumen de: US20260055354A1

A bioreactor allowing bioprinting inside an interior volume thereof is assembled to form a side wall extending upwardly from a base provided with a target support for the bioprinting. Once an adapter has been coupled to a bioreactor top portion to plug a corresponding aperture O4, a biological material depositing end may be maintained in an inserted state, extending through and/or being adapted to be fed via the aperture. A sealed enclosure, including the side wall and ports, is formed by a sealing operation to interconnect the base and the top portion. Bioprinting is done by driving from outside the depositing end, using variation of said volume, for delivering the biological material on the support and then, a culture and/or maturation phase of the printed tissue may start inside the enclosure, without displacement of the printed tissue.

ADDITIVE MANUFACTURING OF EMBEDDED MATERIALS

Resumen de: US20260053988A1

In one aspect, a method includes providing support material within which the structure is fabricated, depositing, into the support material, structure material to form the fabricated structure, and removing the support material to release the fabricated structure from the support material. The provided support material is stationary at an applied stress level below a threshold stress level and flows at an applied stress level at or above the threshold stress level during fabrication of the structure. The provided support material is configured to mechanically support at least a portion of the structure and to prevent deformation of the structure during the fabrication of the structure. The deposited structure material is suspended in the support material at a location where the structure material is deposited. The structure material comprises a fluid that transitions to a solid or semi-solid state after deposition of the structure material.

POROUS INTERBODIES

Resumen de: US20260053633A1

In various aspects, an implant includes a body having a lattice structure, with the lattice structure extending continuously from a superior surface of the body to an inferior surface of the body. The lattice structure may define a gradient of pores, with each pore in the gradient having a plurality of vertices. Additionally, the implant may include a plurality of projections extending superiorly from each of the plurality of vertices of each pore of the gradient of pores at the superior surface of the body, with each projection of the plurality of projections having a directionality. The implant may also include one or more radiographic markers incorporated into the lattice structure, the one or more radiographic markers having a density greater than the density of the lattice structure immediately around the one or more radiographic markers and being comprised of the same material as the lattice structure.

MANUFACTURE OF PATIENT-SPECIFIC ORTHODONTIC BRACKETS WITH TOOTH-SPECIFIC BREAKAWAY MECHANISM

Resumen de: US20260053596A1

Embodiments may provide improved techniques for creating custom lingual or labial ceramic orthodontic brackets, and which provides the capability for in-office fabrication of such brackets. For example, a method of manufacturing customized ceramic labial/lingual orthodontic brackets by ceramic slurry-based AM may comprise measuring dentition data of a profile of teeth of a patient, based on the dentition data, creating a three dimensional computer-assisted design (3D CAD) model of the patient's teeth using reverse engineering, and saving the 3D CAD model on a computer, designing a 3D CAD bracket structure model for a single labial or lingual bracket structure, importing data related to the 3D CAD bracket structure model into a ceramic slurry-based AM machine, directly producing the bracket (green part) in the ceramic slurry-based AM machine by layer manufacturing, and processing the brackets in a sintering and debinding oven prior to direct use.

MICRONEEDLE PARTICLES FOR ENHANCED TOPICAL TRANSDERMAL DRUG DELIVERY

Resumen de: US20260053731A1

A microneedle particle arranged to be rolled and massaged on a subject's skin to penetrate the stratum corneum is disclosed. The microparticle comprises a support body, and a plurality of microneedles protruding from the support body (20), each microneedle comprising a tip. The support body maintains the microneedles and tips in a predetermined conformation allowing the microneedle particle to be rolled on the skin. The microneedles have an average tip sharpness radius of less than 20 μm, an average microneedle length of less than 100 μm, and an average tip sharpness to microneedle length ratio of 1:5 to 1:200. Formulations and kits for said use are provided. A microneedle particle manufacturing method using a non-linear two-photon absorption process, a non-therapeutic cosmetic method of skin treatment, and a method of drug delivery through the skin for said microneedle particle are disclosed.

POROUS INTERBODIES

Resumen de: WO2026043576A1

In various aspects, an implant includes a body having a lattice structure, with the lattice structure extending continuously from a superior surface of the body to an inferior surface of the body. The lattice structure may define a gradient of pores, with each pore in the gradient having a plurality of vertices. Additionally, the implant may include a plurality of projections extending superiorly from each of the plurality of vertices of each pore of the gradient of pores at the superior surface of the body, with each projection of the plurality of projections having a directionality. The implant may also include one or more radiographic markers incorporated into the lattice structure, the one or more radiographic markers having a density greater than the density of the lattice structure immediately around the one or more radiographic markers and being comprised of the same material as the lattice structure.

CURABLE COMPOSITION FOR THREE-DIMENSIONAL STEREOLITHOGRAPHY, METHOD FOR PRODUCING OBJECT BY THREE-DIMENSIONAL STEREOLITHOGRAPHY, AND METHOD FOR PRODUCING DENTAL RESTORATION

Resumen de: WO2026042469A1

Provided is a curable composition for three-dimensional stereolithography, the curable composition containing 100 parts by mass of a radical polymerizable monomer (A), 5.0-400 parts by mass of an inorganic filler (B), 0.05-10.0 parts by mass of a photopolymerization initiator (C) containing an acylphosphine compound, 0.01-5.0 parts by mass of a polymerization inhibitor (D), and 0.01-10.0 parts by mass of a photosensitizer (E) including a thioxanthone compound represented by formula (1). The present invention also provides a method for producing an object by three-dimensional stereolithography and a method for producing a dental restoration, the methods using said curable composition for three-dimensional stereolithography. In the formula, Y1 to Y8 each independently represent a hydrogen atom, an alkyl group having 1-20 carbon atoms, or the like.

METHOD OF TREATING A WOUND AND METHOD OF MANUFACTURING A SKIN GRAFT

Nº publicación: WO2026043980A1 26/02/2026

Solicitante:

THE RESEARCH FOUNDATION FOR THE STATE UNIV OF NEW YORK [US]
THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK

Resumen de: WO2026043980A1

Synthetic skin constructs are produced using 3D bioprinting and a cleaning process involving supercritical carbon dioxide (ScCO2). The ScCO2 process effectively removes all cellular materials, minimizing the risk of immune rejection and ensuring the skin constructs are safe and optimally effective.