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167
resultados
Última actualización
07/12/2025 [07:10:00]
Resultados 25 a 50 de 167
Resumen de: WO2025248557A1
This invention relates to the preparation of bone grafts from human hard tissues, such as teeth, bone, and cartilage, that retain osseoinductive potential. The grafts are processed through optimized lab procedures to preserve their biological activity, achieve sterilization, and minimize water content for enhanced shelf life. These grafts can be formulated into particulate, block, or dough/pastel - like forms. The particulate matter can be combined with body fluids containing growth factors to create a moldable material for packing into bone defects, promoting superior osteogenesis. Additionally, the particulate matter can be used in 3D printing to produce customized grafts with controlled porosity based on CT scans and computer-aided design (CAD). Block grafts can be machined into precise shapes using CAD models and computer-aided machining (CAM).
Resumen de: WO2025250016A1
Herein is disclosed a method of manufacturing a seat unit for a wheelchair, and a seat unit for a wheelchair The method comprises the steps of determining a user's needs for support and pressure relief, and thereafter selecting a basic seat cushion module (1) and a basic backrest module (2) before 3D-printing a seat unit adaptation module (4; 5) using information about the determined support and pressure relief needs of the user, for adapting the basic seat cushion module (1) and/or the basic backrest module (2) to the user. The adaptation module (4; 5) is printed with an open 3D structure (3).
Resumen de: US2025366958A1
Systems and techniques for training one or more neural networks to automatically determine placement of a digital representation of an orthodontic appliance are disclosed including comparing one or more aspects of the second representation of a 3D printed part with one or more respective aspects of a first representation of the 3D printed part, generating a reconstruction error based on the comparing, and when the reconstruction error is greater than a predetermined threshold, assigning one or more result labels that specify that the respective aspects of the 3D printed part were not correctly fabricated and when the reconstruction error is less than the predetermined threshold, assigning one or more result labels that specify that the respective aspects of the 3D printed part were correctly fabricated.
Resumen de: US2025366922A1
A plate for fixating bone, the plate comprising: a plurality of ribs defining a plurality of openings, wherein a first portion of the plurality of ribs define a lattice structure and a second portion of the plurality of ribs define at least four mounting holes. Another aspect of the present disclosure relates to a method for tailoring a plate for fixating bone. The method can include determining an initial design of the plate. The method can include analyzing radiation through the initial design. The method can include determining, based on analyzed radiation, if dosimetric characteristics are desirable. The method can include analyzing structural strength of the initial design. The method can include determining, based on the analyzed structural strength, if structural strength is sufficient.
Resumen de: US2025366953A1
Systems for orthodontic treatment are provided. In some embodiments, a system includes an attachment configured to be coupled to a tooth of a patient. The attachment can include a first surface configured to contact the tooth, a second surface opposing the first surface, and one or more sidewalls connecting the first surface and the second surface. The first surface, the second surface, and the one or more sidewalls can form a solid enclosed volume having a protruding shape. The system can further include an orthodontic appliance including a shell having a plurality of teeth-receiving cavities shaped to reposition the patient's teeth from a first arrangement toward a second arrangement, and an attachment-receiving well formed in the shell. The attachment-receiving well can engage the attachment to effect a movement of at least one tooth of the patient. The attachment can have a different geometry than the attachment-receiving well.
Resumen de: US2025367348A1
A method for reinforcing a cellularized retinal construct fabricated from (i) endothelial cells; (ii) retinal pigment epithelial cells and/or photoreceptors; and (iii) an extracellular matrix (ECM) hydrogel is disclosed. The method comprises contacting the construct with a biocompatible small-molecule reinforcing agent that is capable of chemically interacting with the ECM hydrogel under conditions that maintain viability of the cells, to thereby increase a compressive modulus of the ECM hydrogel by at least 10%.
Resumen de: WO2025247746A1
A method for manufacturing a medical bone connecting device (10) is proposed that serves to connect two bones (V, H) or bone parts of a human or animal patient. The method comprises at least the following steps: a.) targeted deposition (80) in a common layer (17) of one or more strands (13) of reinforcing fibers (11) embedded in a matrix material (12), b.) repetition (81) of step a.) for a plurality of successive layers (17), in order to produce a preform (18) of the bone connecting device (10), and c.) compression (82) of the preform (18) in a mold (70) to form the bone connecting device (10). The strand or strands (13) are deposited in such a way in step a.) that they follow a multiple curved path (15) without crossing themselves or each other. Furthermore, a bone connecting device (10) manufactured according to this method is disclosed.
Resumen de: WO2025247979A1
The invention relates to a pharmaceutical formulation suitable for the manufacture of unit doses of a solid or semi-solid medicament by 3D printing, to a printing cartridge containing such a pharmaceutical formulation, and to the use of this pharmaceutical formulation for the manufacture of unit doses of a solid or semi-solid medicament by 3D printing, to a printing cartridge containing such a pharmaceutical formulation, and to a method for preparing a medicament in the form of unit doses by 3D printing using such a formulation.
Resumen de: US2025367422A1
A microneedle array is provided for administrating a drug or other substance into a biological tissue. The array includes a base substrate; a primary funnel portion extending from one side of the base substrate; and two or more solid microneedles extending from the primary funnel portion, wherein the two or more microneedles comprise the substance of interest. Methods for making an array of microneedles are also provided. The method may include providing a non-porous and gas-permeable mold having a two or more cavities each of which defines a microneedle; filling the cavities with a fluid material which includes a substance of interest and a liquid vehicle; drying the fluid material to remove at least a portion of the liquid vehicle and form a plurality of microneedles that include the substance of interest, wherein the filling is conducted with a pressure differential applied between opposed surfaces of the mold.
Resumen de: US2025366997A1
The present invention relates to a method for using a lyophilization hyaline cartilage powder to produce a composition for regenerating cartilage, and a composition for regenerating cartilage produced by using the method, the method comprising: A) a step for preparing hyaline cartilage; B) a step for freeze-drying and crushing the hyaline cartilage, and producing a lyophilization hyaline cartilage powder; C) a step for producing an adipose tissue extract from autologous adipose tissue; and D) a step for producing a composition which is for regenerating cartilage and including the lyophilization hyaline cartilage powder and the adipose tissue extract.
Resumen de: WO2024156635A1
The invention relates in a first aspect to a cardiac pacemaker construct comprising a three-dimensional core structure comprising pacemaker cells and fibroblasts, produced in vitro, or producible in vitro, by means of an additive manufacturing process and/or a moulding process. A second aspect of the invention relates to a method for producing a cardiac pacemaker construct, in particular a cardiac pacemaker construct according to the first aspect of the invention. A third aspect of the invention relates to a cardiac pacemaker construct obtained or obtainable by the method of the second aspect. A fourth aspect of the invention relates to the use of a cardiac pacemaker construct according to the first aspect, or a cardiac pacemaker construct according to the third aspect, for investigating the effect of substances, in particular harmful substances and/or medications, on the function of the sinoatrial node.
Resumen de: EP4656661A1
Block copolymer according to Formula 1 and methods for producing the same,wherein n is a value of from 5 to 250; W1 is a group according to Formula 2, which is attached to the Si atom of Formula 1 via X:The block copolymers are suitable to improve fracture toughness of radically polymerizable compositions. These compositions are particularly suitable as dental materials.
Resumen de: AU2023377822A1
A detachable printhead for a bioprinter is disclosed, the detachable printhead comprising a body, removably attachable to a fixed portion of the bioprinter; a dispensing system, supported by the body; one or more reservoirs, for holding one or more biomaterials, in fluid communication with the dispensing system, supported by the body; and a coupling for attaching to the fixed portion of the bioprinter, the coupling including an interface for operating the dispensing system.
Resumen de: CN223618264U
本实用新型公开了一种牙套生产用3D打印设备，包括打印设备外壳、打印设备和打印件，所述打印设备外壳的底部内壁上开设有滑动槽，滑动槽内滑动安装有滑动块，滑动块的一端延伸至滑动槽内，滑动块的另一端延伸至滑动槽外，滑动块延伸至滑动槽外的一端固定安装有托板，打印设备外壳的一侧内壁上开设有开孔，托板的一端穿过开孔延伸至打印设备外壳外，托板的底部一侧固定安装有竖杆，打印设备外壳的一侧开设有凹槽，凹槽内滑动安装有横杆。该实用新型在打印设备内设有可水平移动的托板，可以在打印结束之后，水平移动托板，使得托板带动打印件滑出打印设备，可以降低打印件的冷却时间。
Resumen de: CN223614912U
本实用新型公开了一种3D打印多孔椎弓根螺钉，包括钉身部和钉帽部，钉身部包括近钉帽部一端的皮质骨螺纹区和远离钉帽部一端的松质骨螺纹区，钉身部非连接钉帽部一端设有多孔结构区，多孔结构区包括沿钉身部轴向延伸的内芯柱、加强梁和多孔结构，加强梁至少设置一个且加强梁自内芯柱周缘向外延伸，多孔结构环布于内芯柱外周缘。本实用新型通过多孔结构能高效诱导骨组织长入，将螺钉与椎体连成一整体，有效分散应力，增加螺钉稳定性，多孔结构设于螺钉前端椎体部分，能够避免螺钉在椎弓根区域因应力集中导致螺钉断裂，同时，加强梁能够更好的提高螺钉稳定性，减少螺钉多孔区域断裂的可能，更具推广性且提升使用体验感。
Resumen de: CN121041508A
本发明公开了一种多级仿生神经膜结构的神经导管制备方法和应用，属于组织工程材料技术领域。本发明的多级仿生神经膜结构的神经导管，包含具有二级引导结构的仿生内膜支架和双层结构的仿生外膜支架。本发明的多级仿生神经膜结构的神经导管中，发挥生长引导作用的填充物具备多级引导结构，一级引导为细胞沿着定向纤维膜中的纤维方向定向迁移，在纤维上拉长形态，加速分化；二级引导为定向微通道约束神经纤维生长，促进集束成熟，对齐生长方向。本发明解决了现有方案存在的接触引导效率不足的问题，并克服了引导纤维填充密度、生长空间与引导效应之间的矛盾。
Resumen de: CN121041503A
本发明提供了光敏陶瓷浆料与光固化3D打印生物陶瓷材料及其制备方法和应用，属于医用生物材料技术领域。本发明提供的光敏陶瓷浆料，按质量份数计，包括以下组分：磷酸二氢铝溶胶50~55份，陶瓷粉末20~25份，单体10~15份，光引发剂0.05~0.10份，稳定剂0.01~0.05份，染料0.01~0.05份，水5~10份。本发明提供的光敏陶瓷浆料经3D打印后所得前驱体具有自由压缩复原、剪裁及个体化填补骨缺损部位的特点，打印过程中出现的瑕疵可以进行修剪，打印后所得前驱体结构出现轻微变形可以自行恢复，避免了光敏树脂经3D打印后存在结构固定、不能自由压缩和剪裁的问题。
Resumen de: CN121042562A
本发明提出一种血管支架及其制备方法，对等原子比镍钛合金粉末进行逐层打印得到镍钛支架基体；在镍钛支架基体的表面原位生成氮化钛阻隔层；将表面改性后的镍钛支架置于熔融镁液中，进行无压渗透，以得到互穿相复合结构的Mg‑NiTi复合材料基体；对复合材料基体进行重熔，通过气流雾化制备得到复合材料细粉；采用选择性激光熔化技术和超快激光强化技术对复合材料细粉进行逐层打印，完成二次增材制造，以制备得到目标三维形态的血管支架。经本发明实施例提供的血管支架制备方法所制备的血管支架兼具高力学强度、可控降解周期，避免长期异物留存，可显著降低术后再狭窄率，适用于心血管、骨科等领域。
Resumen de: CN121041609A
本发明属于近距离放射治疗医疗器械技术领域，尤其涉及一种施源器及其制备方法，施源器采用3D打印技术制备，其原料各组分配比以质量百分比计，Cu：13‑15％，Zr：8‑10％，Mo：8‑10％，Nb：6‑9％，Sn：2.5‑3.5％，Si：0.5‑1.5％，余量为Ti。本发明通过添加Zr、Mo、Nb、Sn等低磁化率元素，将钛合金的磁化率降至纯钛磁化率的1/3，形成一种β相钛合金，再利用3D打印工艺和热等静压工艺制备成型为含ω相的钛合金施源器，其磁化率更小，使MRI成像伪影面积减少，源到位精度更高，降低了对危及器官的不利影响。
Resumen de: WO2024188674A1
The invention relates to an apparatus for producing three-dimensional screen-printed workpieces, in particular a 3D screen printing installation, said apparatus comprising: a printing device for the layer-by-layer production of at least one screen-printed workpiece in a plurality of printing operations; and a transport device for the automated transport of at least one screen-printed workpiece and/or a workpiece carrier to and/or from the printing device, wherein the transport device has at least one transport rail and a conveyor vehicle, which is movably mounted on the transport rail, for at least one screen-printed workpiece and/or at least one workpiece carrier.
Resumen de: CN121043407A
本申请公开了患者特异性血管介入球囊的3D打印模型生成系统，包括影像建模模块从患者DICOM影像提取血管几何与解剖特征参数，生成带解剖特征标注的三维模型，为球囊设计提供基础；球囊构建模块依据血管三维模型中的血管曲率和弯曲动力学参数，标记高危区域并升级模型，设计出贴合血管实际的初始球囊三维模型；应力调整模块构建涵盖球囊多方面参数的规则库，通过仿真优化球囊应力分布，防止应力集中；打印处理模块根据优化后的球囊结构，利用3D打印实现材料分区与密度梯度控制，制造出患者专属球囊；此方案能提升球囊与血管的适配性，增强扩张效果，降低手术风险，有力支持个性化医疗。
Resumen de: CN121043404A
本发明公开了一种个性化牙齿3D打印设备及其方法，涉及3D打印技术领域，包括打印主体，所述打印主体内设有用于存放液体树脂的树脂框，所述树脂框的上方装配有牵引组件，所述打印主体的前表面安装有能够操控牵引组件往复升降打印义齿的触摸操控屏，所述触摸操控屏的下方设有连接于打印主体前表面的门体；牵引组件包括固定于打印主体内壁的驱动部件。本发明通过铲除组件的设置，能够自动对义齿床上成型的义齿模具以及边料进行铲除，在铲除过程中，通过振动电机的设置，使得铲条能够往复横向振动，进而增加了铲除组件铲除义齿模具以及边料的稳定性，避免了因铲除力度过大而导致义齿模具出现损坏的情况。
Resumen de: CN121041510A
本发明公开了一种用于制备糖尿病创面修复水凝胶的3D打印生物墨水，包括组分A羟丁基功能化壳聚糖、组分B季铵基与醛基共修饰的甲壳素等；所述组分A由壳聚糖分散在NaOH溶液与异丙醇溶液中，与环氧丁烷反应制得；所述组分B由甲壳素分散在NaOH‑尿素溶液中，与2，3‑二氧基三甲基氯化铵反应，然后将产物分散在水中再与NaIO4反应制得。本发明的3D打印生物墨水，可以直接在伤患创面处进行原位打印形成修复水凝胶，能够完美贴合创面，该水凝胶利于伤口愈合，具备抗菌性能、对细胞无副作用，还可根据糖尿病创面在不同阶段需要不同药物的需求制备出负载不同药物的上下两层结构，实现在不同愈合阶段缓释不同药物，从而显著促进糖尿病等难愈合性创面的愈合。
Resumen de: WO2024216245A1
The present disclosure provides a support of a 3D printed orthodontic dental appliance is provided. The orthodontic dental appliance includes a shell structure defined by an inner contour surface and an outer contour surface. The support comprises: a middle support including a middle support base mesh and a plurality of middle support struts and a main support configured to connect the middle support to a build platform of a 3D printing device used to print the orthodontic dental appliance. One end of each middle support strut of the plurality of middle support struts is connected to the orthodontic dental appliance at a junction of the inner contour surface and the outer contour surface, and the other end of the middle support strut is connected to a rim of the middle support base mesh.
Nº publicación: CN121041523A 02/12/2025
Solicitante:
吉林大学
Resumen de: CN121041523A
本发明公开了用于治疗骨不连的骨整合式可降解硅胶支架及其制备方法，涉及医疗植入材料技术领域，该制备方法包括：使含氢硅油与烯丙基缩水甘油醚在铂催化剂作用下发生硅氢加成反应，生成含环氧基团硅油，随后在催化剂作用下使环氧基团开环，得到侧链含磷酸酯基团的硅油；将端羧基聚乳酸‑乙醇酸共聚物与侧链含磷酸酯基团的硅油混合，在缩合剂和催化剂作用下进行缩合反应，得到PLGA‑P‑PDMS‑PLGA三嵌段共聚物；将三嵌段共聚物、反应性稀释剂、光引发剂和无机增强填料混合制得3D打印浆料；使用光固化3D打印技术，根据设定的打印参数，将打印浆料打印成所设计的骨整合支架。通过本发明赋予了材料本征成骨活性，实现了生物活性、形状记忆功能与力学支撑的统一。
BOPI
Sede Electrónica
