Resumen de: CN121130046A
The invention belongs to the technical field of antibacterial synergists, and discloses application of ramoplanin as a colistin antibacterial synergist. The invention provides a treatment strategy for combined use of ramoplanin as a polymyxin drug sensitizer in treatment of gram-negative bacterial infection, and in a test of combined use of ramoplanin and colistin for detection of a bacterial sterilization curve and the integrity of a bacterial outer membrane, the concentration of the ramoplanin is low and is only 16 mu g/mL; in the aspect of the antibacterial effect, the FICI index is relatively low, and after the ramoplanin and the colistin are jointly used, the MIC (Minimum Inhibitory Concentration) of the colistin can be reduced by 16 times at most. The research shows that ramoplanin is a promising antibiotic sensitizer, and can be used in combination with the polymyxin drug colistin to resist the colistin drug resistance problem of escherichia coli, salmonella and klebsiella pneumoniae.
Nº publicación: CN121142029A 16/12/2025
Solicitante:
GUANGDONG PROVINCIAL PEOPLES HOSPITAL
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Resumen de: CN121142029A
The invention belongs to the technical field of biological detection, and discloses a rapid immunochromatography detection kit for gastrointestinal pathogenic bacteria based on a viral nano-enzyme probe. The invention discloses a nano-enzyme probe, the virus-shaped nano-enzyme probe provided by the invention takes Fe3O4 nano-particles as a core, Pt nano-particles and Au (at) Pt nano-particles are coated in sequence, a specific antibody is modified, and the nano-enzyme probe has a magnetic enrichment effect and a multi-catalytic-site characteristic at the same time; rapid capture and high-sensitivity quantitative detection of various gastrointestinal pathogenic bacteria in complex matrixes (river water samples, lake water samples and excrement samples) can be realized, and matrix interference in practical application is eliminated; and the kit has huge potential in the aspects of high-sensitivity field screening and clinical monitoring of infection of gastrointestinal bacteria (such as escherichia coli, salmonella and helicobacter pylori).