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LACTIPLANTIBACILLUS PLANTARUM GOLDGUT-LP618 HAVING FUNCTION OF RESISTING SALMONELLA INFECTION AND APPLICATION THEREOF

Resumen de: AU2024256082A1

The present invention relates to the technical field of probiotics, in particular to a Lactiplantibacillus plantarum GOLDGUT-LP618 having a function of resisting Salmonella infection and application thereof. The Lactiplantibacillus plantarum GOLDGUT-LP618 provided by the present invention is preserved in China General Microbiological Culture Collection Center, with the preservation number of CGMCC No. 28399. The strain has high resistance to acid and bile salt and can adapt to the digestive tract environment. The strain can inhibit Salmonella infection, relieve diarrhea, inflammation and intestinal damage caused by Salmonella infection, and promote intestinal health. The strain can be used for preparing functional foods, dietary supplements or drugs that can resist Salmonella infection and improve diarrhea and inflammation caused by Salmonella infection, and has good application prospects.

METHOD FOR PREPARING FREEZING SHOCK-TREATED MONOCYTES OR MACROPHAGES LOADED WITH ATTENUATED SALMONELLA AND USE THEREOF

Resumen de: WO2025102801A1

Provided are a method for preparing freezing shock-treated monocytes or macrophages loaded with attenuated Salmonella and the use thereof. The method comprises: loading engineering-modified attenuated Salmonella in monocytes or macrophages, and performed a freezing shock treatment on the monocytes or macrophages loaded with the strain by means of liquid nitrogen. The method for preparing the freezing shock-treated immune cells loaded with the strain is simple and easy to operate. The source problem of the monocytes or macrophages loaded with the engineering-modified attenuated Salmonella is solved, and the method has good application prospects. According to the strategy, by means of avoiding exposure and heterologous stimulation of bacteria, the biological safety of bacteria-based anti-tumor treatment is improved; and the anti-tumor immune response is promoted by means of the high titer of an intratumoral strain, so that a stronger anti-tumor efficacy is obtained.

RAPID DETECTION METHOD FOR SALMONELLA USING POLYDIACETYLENE-BASED COLOR-CHANGING LIPOSOME PARTICLES

Resumen de: KR20250069736A

폴리디아세틸렌 기반 색 변이 리포좀 입자를 이용한 살모넬라균의 신속한 검출방법을 개시한다. 상기 살모넬라균의 신속 검출방법은 (1) 살모넬라균을 박테리아 단백질 추출 시약에 용해시켜 살모넬라균 조각으로 추출하여 살모넬라균을 전처리하는 단계; (2) 전처리된 살모넬라균과 리포좀 입자를 혼합하여 혼합액을 제조하는 단계; 및 (3) 상기 혼합액의 색변환을 분석하여 살모넬라균을 검출하는 단계;를 포함하고, 살모넬라균을 신속하게 검출할 수 있다.

Basa fish Nat10 antibacterial peptide as well as coding sequence, application and preparation method thereof

Resumen de: CN120004982A

The invention discloses a Basa fish Nat10 antibacterial peptide as well as a coding sequence, application and a preparation method thereof, an antibacterial peptide precursor gene sequence is screened and identified from a Basa fish multi-omics data set based on a multi-omics method and biological big data, and an amino acid sequence of the Basa fish Nat10 antibacterial peptide as shown in SEQ ID NO: 3 is obtained through translation design; activity simulation prediction and in-vitro experiments prove that the Basa fish Nat10 antibacterial peptide has an inhibiting effect on growth activity of streptococcus agalactiae, salmonella enteritidis, staphylococcus aureus, vibrio anguillarum and escherichia coli, and particularly has the best antibacterial effect on staphylococcus aureus at the concentration of 2.5 mu mol/L. The compound can be used for preparing various sterilization preparations including bacteriostatic agents, medicines or additives and the like, and has good practical value and social and ecological benefits.

Application of salinomycin in prevention and treatment of pathogenic microorganisms

Resumen de: CN119999693A

The invention discloses application of salinomycin to prevention and treatment of pathogenic microorganisms. According to the present invention, the compound provides significant inhibition activity for agricultural fungi such as Sclerotinia sclerotiorum, Botrytis cinerea, Pyricaria oryzae, Moniliniafacticola ACCC 36263, food-borne bacteria such as Escherichia coli O157: H7ATCC 35150, Bacillus cereus BN CC 103930, Listeria monocytogenes ATCC 19115 and Salmonella enteritidis ATCC 14028, and further provides a certain inhibition effect on other agricultural pathogenic bacteria, such that the compound is expected to be developed into the one type of the compound,

Basa fish Mob1b antibacterial peptide as well as coding sequence, application and preparation method thereof

Nº publicación: CN120004981A 16/05/2025

Solicitante:

SHENZHEN HUADA MARINE RES INSTITUTE
SHENZHEN UNIV
\u6DF1\u5733\u5E02\u534E\u5927\u6D77\u6D0B\u7814\u7A76\u9662,
\u6DF1\u5733\u5927\u5B66

Resumen de: CN120004981A

The invention discloses a Basa fish Mob1b antibacterial peptide as well as a coding sequence, application and a preparation method thereof, an antibacterial peptide precursor gene sequence is screened and identified from a Basa fish multi-omics data set based on a multi-omics method and biological big data, and an amino acid sequence of the Basa fish Mob1b antibacterial peptide as shown in SEQ ID NO: 3 is obtained through translation design; activity simulation prediction and in-vitro experiments prove that the Basa fish Mob1b antibacterial peptide has an inhibition effect on growth activity of streptococcus agalactiae, salmonella enteritidis, staphylococcus aureus, vibrio anguillarum and escherichia coli; the compound can be used for preparing various antibacterial agents, especially gram-positive bacteria streptococcus agalactiae, gram-negative escherichia coli staphylococcus aureus and vibrio anguillarum, can show an antibacterial effect when the concentration is 2.5 mu mol/L, can achieve the best antibacterial effect when the concentration is 5 mu mol/L, can be used for preparing various antibacterial agents and the like, and has good practical value and social and ecological benefits.