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106
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Resumen de: CN121824778A
The invention discloses a salmonella paratyphi targeting antibacterial peptide as well as a preparation method and application thereof, and belongs to the field of bioengineering, and the sequence of the antibacterial peptide is as shown in SEQ ID No.1; the invention further discloses application of the antibacterial peptide targeting the salmonella paratyphi to preparation of a medicine for treating salmonella paratyphi infectious diseases. The antibacterial peptide disclosed by the invention has efficient targeted bactericidal activity on salmonella paratyphi, and has no toxicity on human red blood cells, so that the antibacterial peptide has the potential of becoming a feed antibiotic substitute.
Resumen de: CN121825777A
The invention provides a culture medium for lactic acid bacteria after-generation and application, the culture medium takes trehalose as a carbon source and a yeast extract as a nitrogen source, so that the growth biomass of lactobacillus plantarum, lactobacillus casei and lactobacillus pentosus can be remarkably increased, the pH is reduced, and the antibacterial ability is improved. Lactobacillus plantarum, lactobacillus casei and lactobacillus pentosus are prepared through the culture medium for the lactobacillus after-generation, so that the lactobacillus after-generation has a good inhibition effect on main food-borne pathogenic bacteria such as escherichia coli, staphylococcus aureus, salmonella, pseudomonas aeruginosa and listeria monocytogenes; the preservative can be widely applied to preservation and preservation of meat products such as chilled chicken and pork. The preparation method of the lactic acid bacteria metagen is simple, convenient, low in cost, natural, safe and suitable for large-scale production.
Resumen de: CN121826192A
The invention provides a primer and a probe group for detecting sheep abortion-causing bacteria and application of the primer and the probe group, and belongs to the technical field of biological detection. The primer and probe group is characterized in that the sequence of the primer and probe group for detecting the listeria is shown as SEQ ID NO.1-3, and the sequence of the probe group for detecting the listeria is shown as SEQ ID NO.2-3; according to the primer for detecting the salmonella abortus, the sequence of the probe group is as shown in SEQ ID NO.4-6; the sequences of the primer and the probe group aiming at Brucella detection are shown as SEQ ID NO.7-9; the sequence of a primer and a probe group for detecting chlamydia psittaci is as shown in SEQ ID NO.10-12. The invention further discloses a kit for detecting chlamydia psittaci. The method has the characteristics of visualization, high sensitivity, strong specificity, simplicity and convenience in operation, short time consumption and the like, realizes rapid differential diagnosis of four sheep bacterial abortion diseases through one-time PCR amplification, and has important advantages in the field of sheep disease diagnosis and identification.
Resumen de: CN121818937A
The invention relates to the technical field of animal feed additives, in particular to a composition with bacteriostatic activity and application thereof. A screening antibacterial experiment of the plant essential oil and the organic acid shows that the composition of the plant essential oil and the organic acid, which is reasonably proportioned, has remarkable antibacterial activity on escherichia coli, salmonella typhimurium, shigella flexneri and clostridium perfringens, and particularly has a very good synergistic interaction effect. The composition of the plant essential oil and the organic acid is preferably thymol, carvacrol and sorbic acid, and the optimal compounding ratio is 3: 1: 1. The plant essential oil and organic acid composition provided by the invention has the advantages of being good in antibacterial effect, low in production cost, natural, non-toxic and the like, provides an effective treatment means for weaned piglets with bacterial diarrhea, and has huge potential commercial value.
Resumen de: CN121831148A
本发明属于抗原检测技术领域，涉及一种基于GOx@ZIF‑90@PDA检测大分子抗原的方法。所述方法包括：(1)在含待测抗原的待测样品中加入多克隆抗体修饰的GOx@ZIF‑90@PDA溶液、单克隆抗体修饰的磁性纳米颗粒进行反应，磁分离后得到沉淀物；(2)向沉淀物中加入葡萄糖溶液进行反应，磁分离后得到上清液；(3)向步骤(2)得到的上清液中加入HRP溶液、TYR溶液、胶体金溶液进行反应；根据待测抗原标准品建立的比色标准曲线和/或拉曼标准曲线计算得到待测抗原的含量。本发明在酶信号放大的基础上，建立基于溶液颜色的比色‑SERS双信号模式，可以有效地提高检测灵敏度，实现大分子抗原的痕量检测。
Resumen de: EP1000000A1
The invention relates to an apparatus (1) for manufacturing green bricks from clay for the brick manufacturing industry, comprising a circulating conveyor (3) carrying mould containers combined to mould container parts (4), a reservoir (5) for clay arranged above the mould containers, means for carrying clay out of the reservoir (5) into the mould containers, means (9) for pressing and trimming clay in the mould containers, means (11) for supplying and placing take-off plates for the green bricks (13) and means for discharging green bricks released from the mould containers, characterized in that the apparatus further comprises means (22) for moving the mould container parts (4) filled with green bricks such that a protruding edge is formed on at least one side of the green bricks.
Resumen de: CN121823545A
The invention discloses biomass carbon dots based on yak hair as well as a preparation method and antibacterial application of the biomass carbon dots. The preparation method comprises the following steps: mixing black yak hair with a nitrogen-containing dopant, carrying out hydrothermal reaction at 150-170 DEG C for 5-10 hours, and carrying out ultrasonic treatment, centrifugation, filtration and dialysis purification on the reaction liquid to obtain the yak hair carbon dots. The method takes waste yak hair as a raw material, and is simple in process, green and economical. The average particle size of the prepared carbon dots is about 2.71 nm, the surfaces of the carbon dots are rich in carboxyl, hydroxyl and amino, and the carbon dots are good in dispersity and excellent in fluorescence property. The carbon dot shows remarkable concentration-dependent antibacterial activity on escherichia coli, staphylococcus aureus, salmonella and methicillin-resistant staphylococcus aureus (MRSA), the bacteriostasis rate on most test bacteria at the concentration of 900 ppm exceeds 90%, and drug resistance is not likely to be induced. The invention provides a new choice for developing an efficient and safe green antibacterial agent, and has a wide application prospect in the fields of biological medicine, food packaging and the like.
Resumen de: WO2024201502A1
Present invention provides fusion proteins with desired reduction in factor H binding, particularly the present invention provides optimized manufacturing process for fusion proteins and formulations comprising the fusion proteins. Present invention provides an efficient platform process for manufacturing an effective vaccine formulation against Neisseria meningitidis that meets multiple criteria including improved immunogenicity, safety, stability, and affordability.
Resumen de: CN121825814A
The invention relates to the technical field of microorganisms, in particular to lactobacillus plantarum NSLP-1 as well as a complex microbial inoculant and application thereof, and discloses the lactobacillus plantarum NSLP-1 with the preservation number of GDMCC NO: 67233. The strain has efficient lipid-lowering capacity and excellent gastrointestinal tract tolerance, and can inhibit intestinal pathogens such as salmonella choleraesuis and staphylococcus aureus. The invention also provides a compound microbial agent containing the strain. The compound microbial agent is prepared by compounding lactobacillus plantarum NSLP-1, bacillus subtilis GL-4 and bacillus velezensis V1 according to the volume ratio of 1: (1-2): (1-2). The strain or the complex microbial inoculant can be used for preparing mulberry twig fermented feed, the crude protein content of the feed can be remarkably increased, the fiber content is reduced, and the fermentation quality is improved. By feeding the fermented feed, the diarrhea rate of the Murrah buffalo can be effectively reduced, and the milk yield and the milk quality can be improved.
Resumen de: CN121818563A
The invention discloses an ultrasonic response type bacterial composite drug-loading system as well as a preparation method and application thereof. The system is formed by taking engineering bacteria as a carrier, grafting chemotherapy prodrug molecules on the surface of the engineering bacteria through atom transfer radical polymerization and then loading a sound-sensitive agent. Compared with the prior art, by optimizing ATRP reaction conditions, efficient grafting of the medicine on the surfaces of bacteria is achieved, and the activity of the bacteria is kept. After intravenous injection, the system is enriched at a tumor site by virtue of a tumor hypoxia targeting carrying drug of attenuated salmonella, and ultrasonic irradiation activates a sound-sensitive agent to generate active oxygen: on one hand, the active oxygen splits a TK bond in a prodrug to release a chemotherapeutic drug, and on the other hand, the active oxygen mediates sonodynamic therapy. The system solves the problems that a traditional drug delivery system is poor in targeting property, uncontrollable in drug release and limited in single treatment effect, and the ATRP technology is mild in preparation process and good in biocompatibility and has wide application prospects in the field of deep tumor targeted therapy.
Resumen de: WO2026076273A1
Described herein are synthetic glycopolypeptides that contain sugars identified as active in mucin. These compounds reduce the virulence of high-priority opportunistic pathogens, including, but not limited to, Salmonella enterica subsp. enterica serovar Typhimurium, Candida albicans, and Gardnerella vaginalis, without reducing the viability of beneficial Lactobacillus crispatus. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
Resumen de: EP1000000A1
The invention relates to an apparatus (1) for manufacturing green bricks from clay for the brick manufacturing industry, comprising a circulating conveyor (3) carrying mould containers combined to mould container parts (4), a reservoir (5) for clay arranged above the mould containers, means for carrying clay out of the reservoir (5) into the mould containers, means (9) for pressing and trimming clay in the mould containers, means (11) for supplying and placing take-off plates for the green bricks (13) and means for discharging green bricks released from the mould containers, characterized in that the apparatus further comprises means (22) for moving the mould container parts (4) filled with green bricks such that a protruding edge is formed on at least one side of the green bricks.
Resumen de: CN121801776A
The invention is applicable to the technical field of microorganisms, and provides a lactobacillus paracasei Jlu-CH9 and application thereof, the lactobacillus paracasei Jlu-CH9 is preserved in China General Microbiological Culture Collection Center on January 4, 2026, the preservation number is CGMCC No.37281, and the preservation address is No.3, Yard 1, Beichen West Road, Chaoyang District, Beijing. The strain Jlu-CH9 obtained by separation has certain tolerance to acid and cholate, has no hemolysis phenomenon, and is sensitive to various antibiotics; the compound has good inhibitory activity on dipeptidyl peptidase IV and has a certain potential of reducing blood sugar. The compound has relatively good inhibitory activity on a plurality of pathogenic bacteria including salmonella typhimurium, staphylococcus aureus, escherichia coli, clostridium perfringens and pseudomonas aeruginosa; the traditional Chinese medicine composition has good prevention and treatment effects on a DSS-induced mouse colitis model, and can repair intestinal barriers, regulate immune balance, remodel intestinal flora homeostasis and relieve colonic atrophy.
Resumen de: CN121796550A
The invention belongs to the technical field of biological medicine, and discloses an application of bavachinin (BVC) as a synergist for removing polymyxin holding bacteria. According to the present invention, the combination of psoralen flavanone methyl ether and polymyxin discovers that the psoralen flavanone methyl ether and polymyxin have good effects on in vitro inhibition of retained bacteria; the component of psoralen flavanone methyl ether is safe, and compared with traditional combined use of antibiotics, the psoralen flavanone methyl ether has a good removal effect on persistent bacteria of salmonella generated by the action of polymyxin, the dosage of the polymyxin can be remarkably reduced, the persistent bacteria are removed to a certain extent, and the safety of a human body is improved. The possibility that the polymyxin generates drug resistance is reduced under the condition that a better sterilizing effect is achieved, and meanwhile, the composition has the characteristics of low price and good curative effect.
Resumen de: CN121805362A
0001 本发明涉及一种基于微电极阵列的电化学适配体传感器及其制备方法与应用，属于传感器技术领域。本发明的电化学适配体传感器包括：微电极阵列，由若干微米级金电极单元有序排列构成，每个电极单元独立实现信号采集与分析；修饰层，包括GO‑PPy/dsDNA
Resumen de: CN121784290A
The invention provides a double-antibody sandwich ELISA detection kit for detecting Escherichia coli BL21 LPS and application thereof, the kit comprises: an ELISA plate coated with a capture antibody, the capture antibody being a mouse polyclonal antibody against Escherichia coli BL21 LPS; the detection antibody is an anti-escherichia coli BL21 LPS (Lipopolysaccharide) rabbit polyclonal antibody; the enzyme-labeled secondary antibody is specifically combined with the detection antibody, and the enzyme-labeled secondary antibody is an HRP labeled goat anti-rabbit IgG enzyme-labeled antibody; and an Escherichia coli BL21 LPS antigen. The kit can specifically recognize LPS from Escherichia coli BL21, effectively eliminate interference of other Gram-negative bacteria LPS, realize accurate detection of target residues, provide a reliable detection means for LPS residue control of fermentation broth, intermediate products and final products in the production process of biological drugs, directly guarantee the quality safety of the biological drugs, and has a wide application prospect. The medication risk caused by LPS residues is reduced, and the health rights and interests of patients are protected.
Resumen de: CN121780736A
The invention discloses a ZIF-8 (at) AuNPs-CRISPR/Cas12a colorimetric biosensor based on assistance of a smart phone and application of the ZIF-8 (at) AuNPs-CRISPR/Cas12a colorimetric biosensor, a novel CRISPR/Cas12a biosensing platform is constructed based on a metal organic framework (MOF) nano enzyme (namely ZIF-8 (at) AuNPs), and the novel CRISPR/Cas12a colorimetric biosensor is used for detecting salmonella typhimurium. In the system, a CRISPR (clustered regularly interspaced short palindromic repeats) system is used as a target recognition and signal transduction module, and a ZIF-8 (at) AuNPs nano composite material with high porosity and oxidase-like activity is used as a colorimetric signal amplification module, so that the CRISPR/Cas12a-ZIF-8 (at) AuNPs colorimetric biosensor is constructed. The sensor shows an excellent linear relation to salmonella typhimurium, and the detection limit is as low as 11 CFU/mL. By establishing a CRISPR colorimetric biosensor platform assisted by a smartphone, salmonella typhimurium detection without instrument assistance is realized, and the huge potential of carrying out hyperstable field detection on food-borne pathogenic bacteria in a food supply chain is shown.
Resumen de: CN121780382A
The invention belongs to the technical field of bacteriophage production, and discloses enterococcus faecalis and application thereof in bacteriophage production, the enterococcus faecalis is named as enterococcus faecalis Ef-GK-563, the preservation number of the enterococcus faecalis Ef-GK-563 is CGMCCNO.32693, and the enterococcus faecalis is preserved in the China General Microbiological Culture Collection Center on November 18, 2024, and the preservation address is No.3, Yard 1, Beichen West Road, Chaoyang District, Beijing. The enterococcus faecalis strain can produce the salmonella bacteriophage across host species and can be applied to bacteriophage production as host bacteria, and the enterococcus faecalis is safe to use as probiotics, so that the production cost of the salmonella bacteriophage can be reduced.
Resumen de: CN121774947A
The invention discloses application of fenofibrate as a florfenicol synergist, and relates to the technical field of prevention and treatment of drug-resistant bacteria. The fenofibrate is used for improving the action efficiency of florfenicol on salmonella drug-resistant bacteria. The invention provides a brand-new theoretical framework and a technical path for improving the curative effect of the existing antibiotics on the premise of not developing new antibiotics.
Resumen de: CN121779517A
The invention discloses a B cell conservative epitope peptide of enterotoxigenic Escherichia coli V-type secretion system effect protein EatA and application thereof, and particularly relates to application in ETEC specific antibody diagnosis. The B cell conservative epitope peptide disclosed by the invention can be functionally displayed and expressed on the surface of an inert carrier S9H thallus, PT8 is displayed and expressed on the surface of the S9H thallus, and an agglutination test directly mediated by the PT8 and specifically recognized by an antibody is established, so that only ETEC pathogen infectious antibodies are specifically recognized, other pathogenic escherichia coli can be identified and diagnosed, and the B cell conservative epitope peptide has a good application prospect. And no cross reaction with serum antibodies of other infectious diseases exists. According to the method, the specific serum antibody can be detected 7 days after a Balb/c mouse is infected by the ETEC strain H10407. The diagnosis method is high in specificity, good in sensitivity, convenient to operate and intuitive in result judgment, and is expected to become a technical means for visual on-site accurate and convenient diagnosis of ETEC infection.
Resumen de: AU2026201863A1
The present invention features compositions comprising an anti-amyloid antibody and methods of treating microbial infection and treating or preventing microbial biofilms using the composition. 5 ar a r
Resumen de: US20260092082A1
An antimicrobial peptide having an amino acid sequence selected from SEQ ID NOs: 2-12 is provided. The antimicrobial peptide has antimicrobial activity against Gram-negative bacteria, Campylobacter jejuni, Escherichia coli, Salmonella enterica subsp. enterica serovar typhimurium, Salmonella enterica subsp. enterica serovar choleraesuis, Klebsiella pneumonica, and/or Enterobacter cloacae. A composition, pharmaceutical composition, food additive, cosmetic composition, or hygine product having an antimicrobial peptide including an amino acid sequence selected from SEQ ID NOs: 2-12 is also provided. A method of treating an infectious disease caused by bacteria including a step of administering a pharmaceutical composition having the antimicrobial peptide as an active ingredient is also provided.
Resumen de: AU2026201838A1
Provided are novel methods for screening and testing for pathogens in food, water, and bodily fluids using methods that are faster to complete than conventional methods of culturing and plating that require lengthy times in properly equipped labs. The invention utilizes specific, rapid and sensitive optical detection to capture small concentrations of the 5 target bacteria and render them amenable for detection with various specific synthesis binding agents approaches. The technique merges capture and detection steps with quantification unit suitable to provide results in a relatively shorter time current detection methods. methods. ar a r m e t h o d s
Resumen de: WO2025037284A2
A vaccine and methods of treatment thereof, wherein the vaccine comprises a recombinant Gram-negative bacteria genetically modified to express a first antigen fusion peptide comprising a neoantigen or series thereof, said neoantigen or series thereof associated with a first secretion signal from a double membrane-spanning secretion system and a second antigen fusion peptide comprising a homologous neoantigen or series thereof, associated with a second secretion signal from an outer membrane-spanning secretion system. The Gram-negative bacteria may be further modified for quadmodal transport. Specifically, the fusion peptides include signal peptides are each associated with a Type III (T3SS) and a Type V (T5SS) secretion system.
Nº publicación: MX2026002010A 01/04/2026
Solicitante:
ELANCO US INC [US]
ELANCO US INC.
Resumen de: MX2026002010A
The present disclosure provides formulations, kits, and vaccines directed to immunization of animals against Salmonella. Methods of usng the formulations, kits, and vaccines for protection of avians against one or more species of Salmonella are also provided.
BOPI
Sede Electrónica
