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Resumen de: WO2025021712A1

The present invention relates to immunogenic compositions comprising antigens from Salmonella enterica serovar Typhimurium (S. Typhimurium), Salmonella enterica serovar Enteritidis (S. Enteritidis), and Salmonella enterica serovar Typhi (S. Typhi). The present invention further relates to methods and uses of compositions comprising GMMA for boosting an immune response to an S. Typhi antigen, vaccines comprising the immunogenic compositions and methods and uses of the immunogenic compositions.

PATHOGENIC SENSING, DIFFERENTIATION AND QUANTIFICATION PLATFORMS

Resumen de: WO2025064651A1

A sensor-enabled pathogen identification, differentiation, and quantification system that integrates into supply chains in an end-to-end fashion and is built on a multi-source, multi-sectoral data environment. The system uses portable sensing platforms that are easily integrated at multiple points along a supply chain and which integrate sample analysis and data processing such that all necessary work can be performed on-site and/or via wireless data transfer.

Nanoshell-modified engineered attenuated salmonella as well as preparation method and application thereof

Resumen de: CN122461499A

The invention belongs to the technical field of biological medicine and nano medicine, and particularly relates to engineering attenuated salmonella modified by a double-layer nano shell layer as well as a preparation method and application of the engineering attenuated salmonella. The engineering attenuated salmonella is of a shell-core structure, modified attenuated salmonella typhimurium VNP20009 engineering bacteria are taken as a core, and the surface of the inner core engineering strain is modified with a nano shell; wherein the engineering bacterium obtained by the modified attenuated salmonella typhimurium VNP20009 is an engineering bacterium VNP20009-GSDMA-N (VNP-G) which is constructed by a genetic engineering means and is used for expressing an N-terminal active structural domain (GSDMA-N) of a Gasdermin E protein, and the modified attenuated salmonella typhimurium VNP20009 and the modified attenuated salmonella typhimurium VNP20009 are constructed by a genetic engineering means; an engineering bacterium VNP20009-LIGHT (VNP-L) for expressing an extracellular functional region of a tumor necrosis factor superfamily member TNFSF14 (LIGHT protein is constructed through a genetic engineering means, and the engineering bacterium VNP20009-LIGHT (VNP-L) is combined with VNP-G. The engineering bacteria can stably express functional proteins in a tumor microenvironment, remarkably enhance local immune response of tumors and induce pyroptosis of tumor cells, so that growth a

Salmonella evolutionary phage for widening host spectrum and application thereof

Resumen de: CN122465856A

The invention discloses a salmonella evolutionary bacteriophage for widening a host spectrum and application thereof, and belongs to the technical field of bacteriophages. The salmonella evolutionary bacteriophage is classified and named as salmonella evolutionary bacteriophage vBSalMJNSP1-E63 (salmonella evolutionary bacteriophage vBSalMJNSP1-E63), and the preservation number of the salmonella evolutionary bacteriophage vBSalMJNSP1-E63 is CCTCC (China Center For Type Culture Collection) NO: M 2026606. Host spectrum determination shows that the evolutionary bacteriophage can be used for cracking 28 salmonella strains with different serotypes, including national standard strains CMCC (B) 50001, CMCC 50014 and CMCC 50094. The optimal infection complex number of the bacteriophage is 0.1, the bacteriophage is kept stable at the temperature of 50 DEG C or below and the pH value of 3-12, and the bacteriophage has high splitting capacity on salmonella and can effectively inhibit salmonella pollution in food matrixes such as milk.

Application of peppermint and lemon mixture in preventing and treating salmonella enteritidis infection of chicks

Resumen de: CN122440611A

The invention belongs to the technical field of poultry breeding, and particularly relates to application of a peppermint and lemon mixture to prevention and treatment of salmonella enteritidis infection of chicks. The peppermint and lemon mixture provided by the invention is easily dissolved in water, is transparent in liquid, and is suitable for drinking water addition of poultry. The result of the embodiment shows that the content of the salmonella enteritidis added in drinking water is obviously lower than that of the enrofloxacin added group; along with the prolonging of the storage time, the pH value of drinking water in each group is gradually increased, but is obviously lower than that of the enrofloxacin group. The carvacrol and citric acid mixture provided by the invention is high in water solubility and strong in stability, can significantly inhibit proliferation of salmonella enteritidis and increase of pH, and has better antibacterial effect than corresponding independent carvacrol or citric acid; according to the present invention, the expression level of the infection-related gene is significantly reduced, the inflammatory response of the body is reduced, the intestinal structure damage caused by the Salmonella enteritidis infection can be easily recovered, the expression of the tight junction protein can be improved, and the intestinal mucosa biological barrier can be adjusted so as to achieve the intestinal mucosa protection effect;

Broiler feed additive, feed and application thereof in resisting salmonella infection

Resumen de: CN122439805A

The invention discloses a broiler feed additive, a feed and application of the broiler feed additive in resisting salmonella infection, and belongs to the technical field of livestock and poultry feed additives. The broiler feed additive comprises one or two of ursolic acid and 3-indolepropionic acid. The invention discloses a broiler feed additive, a feed and application of the broiler feed additive in salmonella infection resistance, the feed additive can improve the growth performance of broilers infected with salmonella, improve the intestinal barrier function and significantly improve the health condition and production performance of the broilers, and has good economic benefits.

SA-MPN encapsulated bacteriophage preparation as well as preparation method and application thereof

Resumen de: CN122440580A

The invention belongs to the technical field of microbial preparations, and particularly discloses an SA-MPN encapsulated bacteriophage preparation and a preparation method and application thereof, the preparation method comprises the following steps: taking a bacteriophage cocktail concentrated solution, and adding a tannic acid solution, a FeCl3. 6H2O solution and a phosphate buffer solution to obtain a metal phenolic network encapsulated bacteriophage; and then sequentially adding a CaCl2 solution and a sodium alginate solution into the metal phenolic network encapsulated bacteriophage to obtain the sodium alginate-metal phenolic network-bacteriophage mixture microcapsule. According to the SA-MPN encapsulated bacteriophage preparation as well as the preparation method and the application thereof, the bacteriophage can be effectively protected from gastric acid, high temperature and ultraviolet stress, and targeted slow release of intestinal tracts is realized; the preparation has the advantages of high entrapment efficiency, good stability, antioxidant activity, obvious bacteriostatic effect on salmonella, and high biological safety.

Primer probe composition for simultaneously detecting salmonella and acinetobacter baumannii, kit and application thereof

Resumen de: CN122445823A

The invention relates to the technical field of microbiological detection, in particular to a primer probe composition and a kit for simultaneously detecting salmonella and acinetobacter baumannii and application of the primer probe composition and the kit, the primer probe composition comprises a primer pair and a probe for detecting salmonella and a primer pair and a probe for detecting acinetobacter baumannii; the nucleotide sequence of the primer pair for detecting the salmonella comprises a sequence as shown in SEQ ID NO.1-2, and the nucleotide sequence of the probe for detecting the salmonella comprises a sequence as shown in SEQ ID NO.3; the nucleotide sequence of the primer pair for detecting the acinetobacter baumannii comprises a sequence as shown in SEQ ID NO.4-5, and the nucleotide sequence of the probe for detecting the acinetobacter baumannii comprises a sequence as shown in SEQ ID NO.6. The invention further discloses a kit for detecting the acinetobacter baumannii. According to the invention, salmonella and acinetobacter baumannii can be quantitatively detected rapidly, sensitively and simultaneously in a single reaction system in a non-interfering manner, and the kit has important application value for clinical rapid screening, hospital infection control and food safety risk monitoring.

Enterococcus firmus C24, probiotic agent and application of probiotic agent

Resumen de: CN122445528A

The invention relates to the technical field of microorganisms, in particular to enterococcus firmus C24, a probiotic agent and application of the probiotic agent. The preservation number of the enterococcus firmus C24 provided by the invention is CGMCC (China General Microbiological Culture Collection Center) No.33995. The enterococcus firmus C24 can be used for preparing the enterococcus firmus. The bacterial strain has broad-spectrum antibacterial activity, has an inhibiting effect on salmonella enteritidis, salmonella pullorum and salmonella typhimurium, is free of hemolysis, has good stress resistance, can survive in a gastrointestinal environment, also has relatively high biological safety, and is expected to be used for clinically preventing and controlling salmonellosis.

Gene prdR for regulating and controlling predation of myxobacteria, protein coded by gene prdR and application of gene prdR

Resumen de: CN122444835A

The invention discloses a gene prdR for regulating and controlling predation of myxobacteria and a protein coded by the gene prdR, and belongs to the technical field of biology. According to the invention, a mutant DK10 with significantly improved predatory ability is obtained by using an adaptive evolution strategy; a genetic variation site of a mutant DK10 is analyzed through a bacterial genome re-sequencing technology, the function of the genetic variation site is researched by combining a gene knockout technology, and it is found that the predation capacity of myxococcus flavus is remarkably enhanced through gene deletion of MXAN2902 (prdR, the nucleotide sequence of which is shown as SEQ ID NO.1). The invention discloses a nucleotide sequence and an amino acid sequence of a transcription activator PrdR for regulating and controlling the predation of myxococcus flavus, a myxococcus flavus functional strain capable of efficiently preying salmonella enteritidis can be developed by utilizing a prdR gene, and a new strategy is provided for the prevention and control of drug-resistant HVPG pathogenic bacteria.

Application of sodium butyrate in preparation of salmonella pullorum resistant feed additive

Resumen de: CN122439777A

The invention belongs to the field of feed additives, and particularly discloses application of sodium butyrate in preparation of a salmonella pullorum resistant feed additive, and the sodium butyrate is added into a chicken basal feed to serve as the salmonella pullorum resistant feed additive. The sodium butyrate is added into the chicken basal feed, so that the bacterium carrying capacity of chicken liver and spleen infected by salmonella pullorum can be remarkably reduced, the ratio of villus length to crypt depth of chicken cecum infected by salmonella pullorum is remarkably increased, and the intestinal absorption capacity is improved; the content of CD3 + T cells, TCR + T cells, macrophages and B cells in the liver of the chicken infected with salmonella pullorum can be obviously reduced; further, the weight of the salmonella pullorum infected chicken is remarkably increased, and the survival rate of the salmonella pullorum infected chicken is increased. In conclusion, by adding the sodium butyrate into the chicken basal feed, the resistance to infection of salmonella pullorum can be enhanced.

Aptamer combination for detecting escherichia coli O157 and biosensor thereof

Resumen de: CN122445651A

The invention discloses a nucleic acid aptamer combination for detecting escherichia coli O157 and a biosensor of the nucleic acid aptamer combination. The nucleic acid aptamer combination for detecting the escherichia coli O157 is composed of nucleic acid aptamers shown in SEQ ID NO: 1-3, the nucleic acid aptamer combination has multiple recognition sites and can perform multi-molecule joint detection on bacterial cells to be detected through the synergistic effect, and the affinity and specificity of the aptamers to target substances are improved; when being applied to a biosensor for detection and used as an important recognition element, the Escherichia coli O157 sensor realizes high-sensitivity detection on Escherichia coli O157 in a biosensing platform, the accuracy reaches 100%, the capturing efficiency on viable bacteria cells is effectively improved, and the sensitivity of the sensor and the detection accuracy are further improved. Meanwhile, the invention provides a method for specifically detecting Escherichia coli O157 by the nucleic acid aptamer combined functionalized biosensor, and more methods and means are provided for detection of food-borne bacteria.

Application of vinblastine in preparation of salmonella infection resisting medicine

Resumen de: CN122440634A

The invention provides application of vinblastine in preparation of a salmonella infection resisting medicine, and belongs to the technical field of biological medicine. The vinblastine is proved to be capable of remarkably reducing the load of salmonella in host cells and relieving pathological damage of target organs caused by salmonella infection, has excellent biocompatibility and in-vivo treatment effect, provides a new choice for developing host-oriented intracellular bacterium infection resisting drugs, and has good clinical application prospect and industrial value.

BACTERIOPHAGES AND USE THEREOF FOR THE TREATMENT OR PREVENTION OF INFECTION CAUSED BY SALMONELLA GALLINARUM

Resumen de: US20260207687A1

0000 A composition of bacteriophages comprising at least one phage selected from TTS1, TTS2, TTS3, TTS4, TTS5, and TTS6, wherein the phages are optionally encapsulated; and a method for preventing or treating an infection caused by Salmonella Gallinarum by administering to a subject a therapeutically effective amount of the composition.

志賀毒素産生大腸菌及び／又は腸管出血性大腸菌を検出及び確認するための方法

Resumen de: WO2025003119A1

The invention relates to a method for detecting and confirming at least one Shiga toxin-producing Escherichia Coli (STEC) which may be present in a sample comprising enterobacteria, comprising the following steps: - performing lysis of the sample, enabling lysis of the STECs in order to obtain a solution comprising the nucleic acids thereof; - bringing the solution of nucleic acids into contact with primers, making it possible to amplify at least the stx1 and/or stx2 gene or gene fragment; - if at least one of the stx1 and/or stx2 genes or gene fragments is amplified, part of the sample is deposited on an agar reaction medium comprising ■ at least one toxin inducer, ■ at least one agglutinating conjugate formed by at least one binding partner specific to the STX1 protein and/or at least one binding partner specific to the STX2 protein, which binding partner(s) is (are) coupled to a nanoparticle; - detecting and confirming the presence of at least one STEC by the appearance of a halo on the agar around the STEC.

一种α和ε型产气荚膜梭菌的融合蛋白、亚单位疫苗组合物及其应用

Nº publicación: CN122427295A 21/07/2026

Solicitante:

天康生物制药有限公司天康制药股份有限公司

Resumen de: CN122427295A

本发明涉及生物技术、动物防疫领域，具体涉及一种α和ε型产气荚膜梭菌的融合蛋白、亚单位疫苗组合物及其应用。本发明通过将产气荚膜梭菌ε蛋白片段、产气荚膜梭菌α蛋白片段、鼠伤寒沙门氏菌鞭毛蛋白片段利用柔性连接肽顺序连接，构建得到了一种无毒力、安全性高、能够有效刺激机体产生抗体的融合蛋白，其氨基酸序列如SEQ ID NO:13所示。该融合蛋白经大量分泌表达后，蛋白含量不低于575μg/mL，蛋白纯度不低于87%。本发明进一步以融合蛋白为抗原，制备得到了一种能够同时预防产气荚膜梭菌α毒素和ε毒素引起的疾病的亚单位疫苗组合物，其制备方法简单、生产成本低，免疫效果好，具有高效的中和与攻毒保护能力，持久免疫应答能力，同时质量稳定、安全性高。