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106
resultados
Última actualización
27/06/2026 [07:08:00]
Resultados 50 a 75 de 106
Resumen de: CN121914217A
The invention belongs to the field of biological medicine, and relates to broad-spectrum antibacterial peptide derived from periplaneta americana and anti-tumor application of the broad-spectrum antibacterial peptide. The PA-1 and the PA-2 are both novel alpha-spiral cationic peptides and show remarkable inhibitory activity on pseudomonas aeruginosa, salmonella typhimurium, staphylococcus aureus, staphylococcus epidermidis and carbapenem-resistant acinetobacter baumannii, and the minimum inhibitory concentration on the carbapenem-resistant acinetobacter baumannii reaches 11 mu mol/L. In addition, PA-1 and PA-2 can also obviously inhibit the growth of human colon adenocarcinoma cells SW480, cervical cancer cells Hela and gastric cancer cells HGC-27, and show better anti-tumor potential. And the PA-1 and the PA-2 have good thermal stability, pH stability, salt stability and enzyme stability. The two novel active peptides PA-1 and PA-2 provided by the invention show relatively high medicinal values in the antibacterial and anti-tumor fields, and particularly provide a new choice for clinical treatment of carbapenem-resistant acinetobacter baumannii infection.
Resumen de: CN121914230A
The invention discloses bacteriocin AM12LCIr as well as a preparation method and application of the bacteriocin AM12LCIr. The invention provides a bacteriocin AM12LCIr, the coding sequence of the bacteriocin AM12LCIr is composed of 46 amino acids, the relative molecular weight is 5067.73 Da, homology analysis shows that the bacteriocin AM12LCIr has the highest homology with class II bacteriocin LCI bacteriocin, but the AM12LCIr and LCI have obvious differences in structure and physicochemical properties, and the bacteriocin AM12LCIr belongs to a novel bacteriocin. According to the present invention, the bacteriocin AM12LCIr is subjected to heterologous expression, and the prepared recombinant protein has good inhibition effect on a variety of bacteria, can inhibit Escherichia coli, Listeria monocytogenes, Enterobacter aerogenes, Salmonella paratyphi B, Staphylococcus aureus and Bacillus cereus, has broad-spectrum antibacterial activity, can be used for preparing more antibacterial products, and has broad application prospects. The invention has important significance for clinically preventing and treating a plurality of pathogenic bacteria including escherichia coli.
Resumen de: CN121915177A
The invention belongs to the technical field of microbiological detection, and particularly relates to a primer and a method for detecting salmonella and a drug-resistant gene thereof and application of the primer and the method. The gene of the salmonella is invA, and the drug resistance genes are blaCTX-M, blaNDM-1, blaTEM-1 and blaOXA; the gene of the salmonella is invA, and the drug resistance genes of the salmonella are blaCTX-M, blaNDM-1, blaTEM-1 and blaOXA; the primers comprise inner primers and outer primers of invA, blaCTX-M, blaNDM-1, blaTEM-1 and blaOXA, a primer group is designed according to conserved regions of a salmonella invA gene and part of beta-lactam drug-resistant genes blaNDM-1, blaTEM-1, blaOXA and blaCTX-M, a detection method of SYBR-LAMP and HNB-LAMP technologies is established, and screening of part of beta-lactam drug-resistant genes carried by animal-derived pathogenic strains is realized.
Resumen de: WO2026084839A1
The present disclosure provides a Salmonella therapeutic delivery system having a modified surface for evading the host immune system, and methods of use thereof.
Resumen de: WO2026085295A1
Provided herein are kits, compositions, systems, and methods for treating a subject with a tumor with kynurenine responsive and degrading bacteria (e.g., such that the bacteria reduces or eliminates the tumor). In certain embodiments, the kynurenine responsive bacteria comprise one or more nucleic acid sequences encoding: i) a kynurenine transcriptional regulator protein, ii) a kynurenine transporter protein, iii) a kynureninase (KynU) protein, and iv) at least one protein important or essential for growth of the bacteria expression of which is linked to a kynurenine responsive promoter (e.g., where the corresponding gene(s) has been deactivated or knocked out in the genome of the bacteria).
Resumen de: CN121896139A
本发明属于兽医生物制品领域，具体涉及一株驴源马流产沙门菌spiC基因缺失株YZUSAL01ΔspiC及其构建方法和应用。本发明的基因缺失株已保藏于中国典型培养物保藏中心，保藏编号为CCTCC NO:M 20252392。该缺失株是利用λ‑Red同源重组技术，将马流产沙门菌的spiC基因敲除后获得的。本发明制备的基因缺失株毒力显著下降，具有良好的安全性。攻毒保护试验表明该菌株对小鼠的攻毒免疫保护效果良好，可诱导高效的体液免疫。本发明为预防马流产沙门菌感染提供了安全、保护效力高的减毒活疫苗奠定基础。
Resumen de: CN121891418A
The invention relates to the field of microorganisms, and discloses application and a method of aspergillus cristatus in preparation of a medicine for treating and/or preventing bacterial infection, and the preservation number of the aspergillus cristatus is CGMCC No.41727. The aspergillus cristatus provided by the invention has an inhibition effect on streptococcus mutans, escherichia coli, staphylococcus aureus and salmonella typhimurium, can secrete various active enzymes, and can relieve the symptoms of bacterial infection, including inhibition of expression of proinflammatory factors, promotion of expression of anti-inflammatory factors and reduction of the number of neutrophils; the aspergillus cristatus provided by the invention can also relieve the symptoms of colitis. The aspergillus cristatus provided by the invention has an application prospect in preparation of drugs for treating and/or preventing bacterial infection.
Resumen de: CN121892129A
The invention discloses a bimetallic nano-enzyme as well as a preparation method and application thereof, and relates to the technical field of biological detection. The bimetallic nano-enzyme is a DNA-Ag/Pt bimetallic nano-enzyme material prepared on the basis of a specific DNA template sequence or containing the specific DNA template sequence, and can be combined with a double-emission ratio type silver nano-cluster to be used for double-signal detection of vibrio parahaemolyticus. The bimetallic nano-enzyme has peroxidase-like activity, the enzyme activity efficiency is adjustable, and the bimetallic nano-enzyme can be used for double-signal detection of vibrio parahaemolyticus. Compared with the prior art, the color development absorbance of the bimetallic nano-enzyme provided by the invention is improved by about 15%, the lowest detection limit of a colorimetric detection method is 10 CFU/mL, and the lowest detection limit of a fluorescence detection method is 1 CFU/mL; the method has no cross reaction on staphylococcus aureus, escherichia coli, pseudomonas aeruginosa, salmonella, vibrio vulnificus and the like, and is suitable for on-site rapid screening, visual interpretation and semi-quantitative detection of scenes such as water samples and marine products.
Resumen de: CN121873260A
The invention relates to an antibacterial peptide, the amino acid sequence of the antibacterial peptide is as shown in SEQ ID NO: 2, or a polypeptide which is obtained by substituting, deleting or adding one or more amino acids to the amino acid sequence as shown in SEQ ID NO: 2 and has antibacterial activity for escherichia coli, staphylococcus aureus and salmonella. The antibacterial peptide disclosed by the invention has a remarkable inhibition effect on main pathogenic bacteria such as escherichia coli, salmonella, staphylococcus aureus and drug-resistant strains thereof in animal husbandry, and is wide in antibacterial spectrum and high in activity; the feed additive has excellent thermal stability and acid resistance, can tolerate feed granulation high temperature and gastric acid degradation, and ensures effective effects of intestinal tracts; the hemolytic activity is low, and the biological safety is high; the expression quantity of a pichia pastoris fermentation tank is greatly improved, the production cost is remarkably reduced, and the economical requirement of large-scale feed addition is met.
Resumen de: CN121874062A
The invention belongs to the technical field of microorganisms, and particularly relates to lactic acid bacteria and application thereof. The bacterial strain is Ligilobacillus sativus SunLab-GHL01 (L.sativus GHL01 for short), is separated from lungs of high-production-performance Ailijiai broiler chickens and is preserved in the China Center for Type Culture Collection (CCTCC), and the preservation number of the bacterial strain is CCTCC NO: M 20251725. The invention further discloses a preparation method of the high-production-performance Ailijiai broiler chicken with high-production-performance Ailijiai broiler chicken with high-production-performance Ailijiai broiler chicken with high-production-performance Ailijiai broiler chicken. Through morphology, physiology and biochemistry, 16S rRNA sequence identification and whole genome sequencing analysis, the taxonomic status and functional characteristics of the 16S rRNA are defined. The strain has good acid resistance, cholate resistance and acid production capacity, has broad-spectrum antibacterial activity, and can effectively inhibit pathogenic bacteria such as escherichia coli, pathogenic escherichia coli, salmonella, staphylococcus aureus and pseudomonas aeruginosa. Animal experiments show that the poultry feed conversion rate and the anti-stress capability can be remarkably improved by atomizing the strain. The strain and the application thereof can be used for improving the health condition and the production performa
Resumen de: CN121874020A
The invention provides lactobacillus reuteri MRL1103 and application thereof, and relates to the technical field of microorganisms and mercury adsorption, the preservation number of the lactobacillus reuteri MRL1103 with a mercury adsorption function is CGMCC NO.28840, the lactobacillus reuteri MRL1103 is separated from fresh chicken manure, the lactobacillus reuteri MRL1103 can tolerate a mercury solution with the concentration as high as 100 mg/L, and under the conditions that the pH is 5 and the concentration of the mercury solution is 5 mg/L, the concentration of the mercury solution can reach 100 mg/L, and the concentration of the mercury solution can reach 100 mg/L; the adsorption rate of the lactobacillus reuteri MRL1103 on mercury in a mercury solution reaches 95% or above, and the lactobacillus reuteri MRL1103 has an inhibition effect on escherichia coli, staphylococcus aureus, salmonella enteritidis, salmonella pullorum or salmonella typhimurium. The lactobacillus reuteri MRL1103 can be used for removing a mercury metal element in a matrix, and the matrix can be mercury-containing soil, a feed or a culture medium.
Resumen de: CN121868347A
The invention belongs to the technical field of biology, discloses a culture supernatant of Brawler's bacteria and application, a preparation method and a medicine of a metabolite of the culture supernatant, and discloses application of the culture supernatant of the Brawler's bacteria to preparation of an anti-inflammatory medicine. According to the application, a chicken infected with salmonella is drenched with a Brawler's metabolite in advance, and tests show that the Brawler's metabolite not only can reduce the death rate of the chicken infected with salmonella, but also has obvious inhibition capability on inflammations of multiple organs of the whole body including intestinal tracts, spleen and the like.
Resumen de: WO2026080385A1
Methods for the detection of subjects at risk of developing rheumatoid arthritis, and subjects having early rheumatoid arthritis thus allowing for early intervention. Compositions for inducing immune tolerance in a subject thus treating or slowing progression of RA. Kits useful in the diagnosis of RA.
Resumen de: WO2024254419A2
Salmonella typhimurium comprising a first heterologous nucleic acid encoding a first polypeptide that causes bacterial lysis, a second heterologous nucleic acid encoding a second polypeptide that causes vacuolar lysis, and a third heterologous nucleic acid encoding a virus.
Resumen de: GB2701058A
A method for quantification of O-specific polysaccharide (OSP) content in a sample, the method comprises: (a) adding a chromogen to the sample to obtain a mixture, where the sample is optionally diluted with a buffer prior to the addition of the chromogen; (b) mixing an acid to the mixture obtain a solution; (c) incubating the solution; (d) subjecting the incubated solution to a spectrophotometric assay or a colorimetric assay; and (e) quantifying the O-specific polysaccharide content in the sample using a mixed saccharide standard solution; where the mixed saccharide standard solution comprises at least two saccharides. The chromogen may be phenol, and the acid may be sulphuric acid. Preferably, the mixed saccharide standard solution comprises rhamnose, mannose, galactose, and paratose in a ratio of about 1:1:1:0.76:1. The method may be used in a method of quantifying the OSP of a conjugate vaccine formulation that induces an immune response against bacterial capsular polysaccharides, such as Typhoid Conjugate Vaccine - Salmonella paratyphi. no figure
Resumen de: CN121856541A
本方案公开了AuNP/BP复合材料生物传感器和病原体检测方法，生物传感器包括AuNP/BP复合材料及生物识别元件；其中，复合材料为多层结构，每层结构由目标厚度的黑磷基底与表面修饰的金纳米颗粒组成。生物识别元件固定在金纳米颗粒表面，用于特异性捕获目标病原体及抗原。该传感器可以快速、灵敏、特异性检测感染性病原体。基于太赫兹波技术，结合AuNP/BP对目的病原体的特异性捕获和电磁感应增强的效果，从而通过光谱信息对病原体加以识别和检测，为病原体的智能化识别提供了可能。为感染性疾病的诊断和后续治疗提供重要依据。
Resumen de: CN121852573A
The invention provides a primer group and a kit for detecting four bacterial abortion diseases of sheep, belongs to the technical field of biological detection, establishes a multiplex PCR (polymerase chain reaction) detection method for sheep brucellosis, sheep abortion salmonellosis, listeriosis and chlamydia disease and a kit thereof, and has the characteristics of high sensitivity, strong specificity, simplicity and convenience in operation, short time consumption and the like. The rapid differential diagnosis of four sheep bacterial abortion diseases can be realized through one-time PCR amplification, and the method has important advantages in the field of sheep disease diagnosis and identification.
Resumen de: CN121852246A
The invention provides bacillus velezensis capable of producing amylase, protease and cellulase and application of the bacillus velezensis, the bacillus velezensis is bacillus velezensis FJAT-10502 and is preserved in China General Microbiological Culture Collection Center on August 6, 2025, the preservation address is No. 3, No.1 Yard, Beichen West Road, Chaoyang District, Beijing, and the preservation number is CGMCC NO. The preservation number is CGMCC (China General Microbiological Culture Collection Center) The amylase production activity of the bacillus velezensis is 181.39 U/mL, the cellulase production activity of the bacillus velezensis is 28.4 U/mL, and the protease production activity of the bacillus velezensis is 18.48 U/mL; the antibacterial activity on escherichia coli and salmonella is achieved, and certain tolerance on artificial gastric juice, artificial intestinal juice and cholate is achieved; when the strain fermentation liquor is used for pomace micro-storage, the content of crude protein and total sugar of pomace can be remarkably increased, meanwhile, the content of crude fiber, acid detergent fiber, neutral detergent fiber and lignin is remarkably reduced, and an effective strain resource is provided for pomace micro-storage fermented feed.
Resumen de: CN121852288A
The invention provides a rabbit-derived plant lactobacillus strain RLP74, a microbial preparation and a feeding probiotic product, and relates to the technical field of microorganisms. The rabbit-derived plant lactobacillus strain RLP74 has strong tolerance to artificial gastric juice and swine bile salt, the survival rate reaches 76% after the rabbit-derived plant lactobacillus strain RLP74 is treated in the artificial gastric juice with the pH value of 2.5 for 3 h, the survival rate reaches 96% after the rabbit-derived plant lactobacillus strain RLP74 is treated in a swine bile salt-containing solution for 4 h, and the survival rate still reaches 68% after the rabbit-derived plant lactobacillus strain RLP74 is continuously digested by the artificial gastric juice for 4.5 h; the bacterial strain has a Caco-2 cell adhesion rate of 33%, has a certain intestinal colonization capability, and has the capability of removing superoxide anion free radicals and bacteriostatic activity on various pathogenic bacteria such as escherichia coli, salmonella, staphylococcus aureus and the like. Therefore, the strain RLP74 or the microbial preparation thereof can be widely applied to preparation of feeding probiotic products for promoting rabbit growth and improving the survival rate of weaned young rabbits, and has good host adaptability and application prospects.
Resumen de: CN121852271A
The invention relates to the technical field of probiotics, in particular to swine-derived probiotic escherichia coli CP57 (Escherichia coli CP57) as well as a preparation method and application of the swine-derived probiotic escherichia coli CP57. The strain is separated from feces of healthy piglets, has good acid resistance and cholate resistance, does not carry virulence factors of common diarrhetic escherichia coli, does not have obvious cytotoxicity and has good safety. The strain can significantly inhibit the growth of salmonella, can relieve clinical symptoms caused by salmonella infection in a salmonella infected mouse model, and reduces the content of salmonella in mouse feces and in vivo. The Escherichia coli CP57 provided by the invention has the potential of preventing and controlling enteropathogenic bacteria infection of livestock, can be used for preparing a microecological preparation for preventing and controlling intestinal infection of livestock, and has important application value.
Resumen de: CN121852335A
The invention belongs to the technical field of biological detection, and discloses a bacteriophage PQ38, application thereof and a salmonella inhibiting medicine, the bacteriophage PQ38 has the preservation number of GDMCC NO: 67169-B1, is preserved in Guangdong Microbial Culture Collection Center, the preservation time is October 27, 2025, and the bacteriophage PQ38 is named as Siphoviridae jerseyvirus in taxonomy; the bacteriophage has a good salmonella splitting capability in salmonella, and tests show that the bacteriophage has an excellent capability of splitting salmonella pullorum.
Resumen de: CN121851118A
本发明属于生物技术与兽医药领域，公开了一种能穿透肠道屏障的耐药沙门氏菌抗菌肽及应用。该抗菌肽能够选择性穿透被感染的宿主细胞（如巨噬细胞、肠上皮细胞）并清除胞内寄生菌，且对宿主细胞无明显毒性。其在肠道局部具备良好的作用稳定性。将该抗菌肽添加于禽类饲料中，可极显著提高沙门氏菌感染禽类的存活率，并显著降低脏器带菌量，其效果显著优于传统抗生素添加剂。本发明提供了一种作用机制清晰、高效安全、不易诱导耐药、符合绿色无抗养殖要求的饲料添加剂新方案。
Resumen de: CN121831130A
0001 本发明涉及生物分析化学技术领域，具体为一种实现多微生物检测的金纳米检测方法。本发明采用无表面活性剂还原法合成具有丰富尖端结构的金纳米星作为高活性SERS基底，利用不同的拉曼报告分子进行编码，并通过异双功能PEG连接臂偶联特异性抗体，制备多重SERS免疫纳米标签；同时，构建功能化免疫磁性纳米粒子，用于从复杂样品中捕获并富集目标菌。检测流程采用“磁性富集‑复合‑SERS光谱读取”模式，形成“磁珠‑细菌‑SERS标签”复合物，通过便携式拉曼光谱仪采集信号并结合解卷积算法，实现对多种病原体的同步定性与定量分析。本发明方法具有检测灵敏度高、检测速度快、抗基质干扰能力强及多重检测无光谱串扰等优点。
Resumen de: CN121831141A
本发明公开了一种Fe3O4@Mo‑CDs纳米酶结合适配体检测食品中大肠埃希氏菌的方法，该方法通过水热法合成了近红外光响应的钼掺杂碳点修饰的Fe3O4@Mo‑CDs纳米酶，其具有优异的NIR增强类过氧化物酶活性和磁性，氧化3,3',5,5'‑四甲基联苯胺产生蓝色氧化型TMB，在其表面功能化大肠杆菌核酸适配体后，Fe3O4@Mo‑CDs纳米酶的类POD活性受到抑制，当大肠埃希氏菌存在时，能选择性结合E.coli，进一步抑制了纳米酶的类POD活性，用于果汁和糕点等样品中E.coli的检测时，检测限低至0.767CFU/mL，具有较高的可靠性和准确性，本发明实现了对E.coli的磁靶向分离和可视化检测。
Nº publicación: CN121824746A 10/04/2026
Solicitante:
龙岩学院江苏省家禽科学研究所中国农业科学院上海兽医研究所（中国动物卫生与流行病学中心上海分中心）
Resumen de: CN121824746A
本发明涉及分子生物学技术领域，具体为一种抗肠炎沙门氏菌的纳米抗体Nb116及其应用和制备方法，本发明公开了抗肠炎沙门氏菌的纳米抗体Nb116的核苷酸序列和氨基酸序列，同时涉及抗肠炎沙门氏菌纳米抗体Nb116在制备降低肠炎沙门氏菌对IPEC‑J2 细胞黏附与侵袭的产品中的应用，以及抗肠炎沙门氏菌的纳米抗体Nb116的制备方法。上述技术方案中提供的抗肠炎沙门氏菌纳米抗体能够降低肠炎沙门氏菌对IPEC‑J2细胞的黏附与侵袭。
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