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97
resultados
Última actualización
28/08/2026 [07:21:00]
Resultados 50 a 75 de 97
Resumen de: CN122303457A
The invention discloses a double-channel quadruple ddPCR detection method and kit for simultaneously detecting diarrhea bacteria in sewage based on a proportional fluorescent probe strategy. Compared with the traditional quadruple detection method with four different fluorescence channels, the quadruple ddPCR detection method disclosed by the invention realizes quadruple detection only through the concentration difference of the probes in the two fluorescence channels. Sewage is used as a key interface between excrement and the environment, is an important place for pathogen storage and transmission, and is also a sentry for early warning. According to the double-channel quadruple ddPCR method established by the invention, salmonella spp. SM, shigella spp. SH, vibrio parahaemolyticus VP and vibrio cholerae VC in the sewage can be simultaneously detected, a sewage monitoring technical method is perfected, potential epidemic situation risks can be captured before disease outbreak, and public health prevention and control measures can be taken in time.
Resumen de: CN122303462A
The invention provides a primer/probe composition for simultaneously detecting shigella and salmonella, a kit and application, and belongs to the technical field of gene detection. The invention comprises a primer/probe set for detecting shigella and a primer/probe set for detecting salmonella. The invention has the advantages of high detection sensitivity, strong specificity, high dual synchronous detection efficiency, good repeatability, good stability and low pollution risk, and is especially suitable for low-load sample detection and rapid screening of monkey group samples.
Resumen de: CN122297427A
The invention discloses a multilayer microsphere for preventing and/or treating bacterial diarrhea as well as a preparation method and application thereof, and relates to the technical field of biological medicines. The multi-layer microsphere is of a three-layer core-shell structure, lactobacillus plantarum and sodium butyrate are loaded on an inner core, a middle layer is a chitosan coating layer, and an outer layer is a sodium alginate coating layer. Research finds that lactobacillus plantarum and sodium butyrate have a remarkable synergistic bacteriostatic effect, and proliferation of pathogenic escherichia coli and salmonella can be efficiently inhibited. In-vivo tests prove that the multi-layer microspheres can effectively recover the body weight of diarrhea animals, repair pathological injuries of jejunum and colon, and reduce intestinal inflammatory response from the molecular level by inhibiting activation of inflammatory pathways of NF-kappa B and MAPK, down-regulating expression of proinflammatory factors IL-1beta, IL-6 and TNF-alpha and up-regulating the level of an anti-inflammatory factor IL-10. The multilayer microsphere provided by the invention can be used as a novel green safe preparation, and is suitable for preventing and controlling bacterial diarrhea in livestock and poultry breeding.
Resumen de: WO2024254147A1
The present disclosure relates, in part, to a polypeptide of formula (I), or a salt or solvate thereof, and a vaccine composition thereof further comprising at least one pharmaceutically acceptable excipient. The present disclosure further relates to isolated mRNA and/or isolated polynucleotides encoding the polypeptide of formula (I), vectors and/or LNPs comprising the same, and pharmaceutical compositions thereof. The present disclosure further relates to methods of treating, preventing, and/or ameliorating a bacterial infection, and/or generating immunity to infection by one or more pathogenic bacteria, in a subject in need thereof, the method comprising administering to the subject at least one composition of the present disclosure. In certain embodiments, the bacterial infection is a urinary tract infection, sepsis (e.g, neonatal sepsis), or pneumonia.
Resumen de: CN122303118A
The invention discloses engineered attenuated salmonella VNP-SNase as well as a preparation method and application thereof, and relates to a method and a composition for treating various solid tumors or metastatic tumors. Specifically, engineered attenuated salmonella capable of expressing and secreting SNase is collected to a tumor microenvironment by utilizing tumor targeting of the engineered attenuated salmonella, neutrophil extracellular trapping nets (NETs) in a tumor are specifically degraded, killing of the NETs on the salmonella is weakened, tumor colonization of the salmonella is improved, meanwhile, tumor promotion and immunosuppression caused by the NETs are improved, and the salmonella can be effectively degraded. And bacteria are effectively prevented from being miss-targeted into normal visceral organs. By releasing SNase to activate/regulate the immune system to directly/indirectly inhibit tumors, the polypeptide can act as an effective immune effector.
Resumen de: CN122297663A
本发明涉及生物蛋白应用技术领域，公开了鞭毛蛋白高变区H作为分子内佐剂在制备疫苗中的应用。鞭毛蛋白高变区H的氨基酸序列如SEQ ID NO.3所示，编码鞭毛蛋白高变区H的基因的核苷酸序列如SEQ ID NO.4所示。本发明还公开了含有编码鞭毛蛋白高变区H的基因的表达盒、重组载体、重组细胞或重组菌。本发明采用上述的鞭毛蛋白高变区H作为分子内佐剂在制备疫苗中的应用，本发明将鞭毛蛋白高变区H与抗原表位相连接得到融合蛋白，与现有技术相比，融合蛋白的可溶性和活性得到提高，同时本发明克服了现有大肠杆菌表达系统中包涵体的表达形式，后期不需要重新折叠组装，精简了疫苗制备工艺。
Resumen de: CN122297462A
The invention discloses application of decursinol angelica ester in preparation of a medicine for treating and/or preventing infection caused by intracellular bacteria, and relates to the technical field of biological medicine. Wherein the application comprises the step of applying an effective amount of decursinol angelica ester to inhibit the survival of the intracellular bacteria in host macrophages. By adjusting the immune function of host macrophages, for example, enhancing the bactericidal activity of the macrophages or changing the intracellular microenvironment of the macrophages, the decursinol angelica ester specifically inhibits the survival and reproduction of intracellular bacteria (such as mycobacterium tuberculosis, mycobacterium abscessus and salmonella) in cells; a new drug candidate and strategy are provided for treating intractable intracellular bacterial infection, and the beneficial effects of enhancing host-oriented antibacterial immunity and reducing toxic and side effects and potential drug resistance are also achieved.
Resumen de: CN122296300A
The invention belongs to the field of microorganisms, and particularly relates to application of an alternaria phenol compound, and the alternaria phenol compound inhibits pathogenic bacteria salmonella, mycobacterium smegmatis, enterococcus faecalis and staphylococcus aureus, inhibits growth of human lung cancer cells and human breast cancer cells, and has bactericidal and anticancer activity. The method is suitable for developing products in the fields of daily home furnishing, medical care, breeding and the like, and has wide industrial application prospects.
Resumen de: KR20260099243A
본 발명은 간접 ELISA에 보조 진단법으로 활용되거나 양돈장에서 돼지 부종병에 대한 감염 여부를 확인하기 위한 적정한 진단법으로 활용될 수 있는 Stx2e에 대한 단클론 항체 및 다중클론 항체를 활용한 sandwich ELISA에 의한 혈중 및 분변 내 Stx2e 항원량 측정 방법에 관한 것이다.
Resumen de: CN122278660A
The invention discloses a microbial agent for fermenting low-nitrite and low-sodium pickled Chinese cabbages and a method for preparing the pickled Chinese cabbages, the microbial agent comprises leuconostoc mesenteroides LM701 and lactobacillus plantarum LP705, the microbial agent has good nitrite degradation capacity, growth of harmful bacteria such as escherichia coli, staphylococcus aureus and salmonella in fermentation of the pickled Chinese cabbages can be effectively inhibited, low-sodium chloride salt fermentation can be achieved, and the low-nitrite and low-sodium pickled Chinese cabbages can be obtained. The nitrite content of the prepared pickled Chinese cabbage is less than or equal to 4 mg/kg, and the pickled Chinese cabbage tastes crisp. The nitrite degradation rate of the fermented pickled Chinese cabbages reaches 63.8% or above. And the nitrite content of a 1% edible salt concentration group is 2.69 mg/kg.
Resumen de: CN122278469A
本发明公开一种无金属毒害的高敏快速荧光探针、制备方法及其在食品致病菌检测中的应用，属于食品检测技术领域。该探针由有机荧光分子石墨烯复合主体、有机无机杂化掺杂剂及特异性识别分子构成；掺杂剂为羧基化纤维素与二氧化硅纳米颗粒，其与复合主体质量比为1:6~10；特异性识别分子采用致病菌适配体，经喷雾涂覆接枝于探针表面。该探针依靠适配体与目标致病菌的特异性结合触发荧光响应，可在5 min内完成检测，灵敏度≥90%，特异性≥98%；探针不含金属成分，无毒害与环境风险，适用于食品现场快速检测及畜禽活体检测；同时制备成本降低90%，单样本检测成本降低40%，具备良好应用前景。
Resumen de: CN122278715A
The invention discloses bdellovibrio and application thereof in cracking salmonella enteritidis, and belongs to the technical field of microorganisms. The preservation number of the strain is CCTCC (China Center For Type Culture Collection) NO: M 20232311, and the HCB006 is a new Bdellovibrio species through multi-phase classification and identification such as 16S rRNA (Ribosomal Ribonucleic Acid) gene, average nucleotide similarity, digital DNA-DNA hybridization and food catching recipe. The invention also discloses a biological control preparation containing the bdellovibrio bacteriovorus and application of the biological control preparation in cracking of salmonella enteritidis. The bdellovibrio HCB006 provided by the invention is high in splitting decomposition efficiency and strong in environmental adaptability, can be used as an antibiotic alternative scheme, is used for biological prevention and control of salmonella in food processing, culture environment and medical related fields, and has important significance on prevention of prevalence of dangerous pathogenic bacteria, improvement of food health and the like.
Resumen de: CN122272777A
The invention belongs to the technical field of molecular biology, and particularly discloses application of a phospholipase PLA2G7 gene in preparation of a preparation for improving salmonella resistance of poultry macrophages, poultry is chicken, the CDS sequence of the phospholipase PLA2G7 gene is shown as SEQ ID NO: 1, and the CDS sequence of the phospholipase PLA2G7 gene is shown as SEQ ID NO: 2. The expression level or activity of the phospholipase PLA2G7 gene in the chicken macrophages is improved to promote the expression of proinflammatory factors of the chicken macrophages and enhance the phagocytosis and sterilization capability of the chicken macrophages on salmonella. Compared with the prior art, the invention proves that the improvement of the expression level or activity of the phospholipase PLA2G7 gene in the chicken macrophage can promote the expression of a proinflammatory factor of the chicken macrophage and enhance the phagocytosis and sterilization capability of the chicken macrophage on salmonella.
Resumen de: CN122271341A
The invention discloses a preparation method and application of a compound bio-enzyme quaternary ammonium salt preparation for pet disinfection. The preparation is prepared from compound quaternary ammonium salt, peony flower bud extract, lysozyme, lysostaphin, lactic acid, sodium hyaluronate and water. The compound quaternary ammonium salt is scientifically compounded with various biological enzymes (lysozyme and lysostaphin), plant extracts (peony bud extracts) and organic acid (lactic acid), the synergistic interaction effect of all the components is fully exerted, and the defects that a single component is narrow in bacteriocidal spectrum, prone to generating drug resistance, large in skin irritation and the like are overcome. The preparation has a rapid and efficient killing effect on various microorganisms such as salmonella typhimurium, escherichia coli, staphylococcus aureus, candida albicans, trichophyton mentagrophytes and poliovirus.
Resumen de: WO2026133273A1
Intact bacterial vesicles are highly effective for in vivo delivery of boron for radiotherapeutic purposes, as in boron neutron capture therapy. A compound comprising a boron isotope, such as boron-10 or boron-11, can be joined chemically to a fluorescent moiety to produce a molecule that can be loaded stably into bacterial vesicles, which when coated with an appropriately targeting bispecific antibody can deliver boron specifically into tumor cells in an amount enabling boron-mediated radiotherapy that eliminates tumor cells with minimal damage to adjacent normal cells.
Resumen de: WO2025037284A2
A vaccine and methods of treatment thereof, wherein the vaccine comprises a recombinant Gram-negative bacteria genetically modified to express a first antigen fusion peptide comprising a neoantigen or series thereof, said neoantigen or series thereof associated with a first secretion signal from a double membrane-spanning secretion system and a second antigen fusion peptide comprising a homologous neoantigen or series thereof, associated with a second secretion signal from an outer membrane-spanning secretion system. The Gram-negative bacteria may be further modified for quadmodal transport. Specifically, the fusion peptides include signal peptides are each associated with a Type III (T3SS) and a Type V (T5SS) secretion system.
Resumen de: CN122256270A
The invention discloses a broad-spectrum bacteriophage targeting mucous escherichia coli, cronobacter and salmonella and application of the broad-spectrum bacteriophage. The invention provides a bacteriophage Escherichia coli phagevB EcoP 3BB7B capable of efficiently cracking mucus type enterobacter, the bacteriophage can specifically crack escherichia coli which can produce corac acid and is in a mucus type phenotype, and the technical bottleneck that adsorption of a mucus layer to most bacteriophages is limited is broken through; compared with the prior art, the recombinant plasmid has the advantages that the recombinant plasmid has high specific activity and cross-genus splitting capacity, not only has good splitting activity on mucus type escherichia coli, but also can effectively split important food-borne pathogenic bacteria such as various serotypes of salmonella, cronobacter sakazakii and the like, and the range of a host spectrum is remarkably widened. The bacteriophage can achieve efficient amplification under the condition of low infection complex number, is good in environmental stability, high in lysis activity, free of drug-resistant genes and toxicity-related genes and high in safety, and has good clinical and food safety prevention and control application prospects.
Resumen de: CN122256177A
The invention relates to the technical field of microorganisms, in particular to bacillus subtilis BS-1 and application of the bacillus subtilis BS-1 in buffalo silage, the strain BS-1 has good bacteriostatic activity on escherichia coli, salmonella and streptococcus uberis, and after the strain BS-1 is mixed with orange peel and manioc waste according to a specific proportion to be fermented, the bacillus subtilis BS-1 can be prepared into the buffalo silage. The antibacterial spectrum of the obtained silage is remarkably enhanced, and escherichia coli, campylobacter jejuni and salmonella causing diarrhea as well as streptococcus uberis, staphylococcus aureus and streptococcus agalactiae causing mastitis can be inhibited at the same time. In the feed, after 60%-75% of orange peel and 25%-40% of manioc waste are mixed, the crude protein content of a fermentation product is remarkably increased, and the fiber content is reduced. Feeding tests show that the feed can significantly improve the lactation yield and milk quality of the milk buffalo in the lactation period and effectively relieve diarrhea. The invention provides the silage which is safe and efficient and has nutrition and disease prevention functions.
Resumen de: CN122256201A
The invention relates to bacteroides fragilis and application thereof, the bacteroides fragilis is preserved in the China General Microbiological Culture Collection Center (CGMCC) on April 14, 2026, and the preservation number is CGMCC No. 38257. The strain can regulate and control STING-dependent training immunity, effectively resist infection of salmonella typhimurium and H9N2 avian influenza virus, maintain the integrity of a host intestinal barrier and relieve inflammatory injury. The bacteroides fragilis provided by the invention has good biological safety, can be used as a training immunity inducer, is expected to be used as a candidate probiotic or vaccine adjuvant for preventing/treating bacterial and virus infection, is suitable for human health and poultry breeding industry, and provides a new solution for resisting antibiotic resistance.
Resumen de: CN122235342A
The invention relates to the technical field of biological detection, and particularly discloses a gene chip for simultaneously detecting 12 food-borne pathogenic bacteria and application thereof, the gene chip comprises a polyvinyl chloride solid-phase carrier, and a specific probe, a positive control probe and a hybridization control probe which are fixed on the surface of the polyvinyl chloride solid-phase carrier. The gene chip can be used for simultaneously detecting salmonella, escherichia coli O157: H7, staphylococcus aureus, listeria monocytogenes, bacillus cereus, vibrio parahaemolyticus, vibrio cholerae, vibrio fluvialis, shigella flexneri, campylobacter jejuni, clostridium perfringens and yersinia enterocolitica. The gene chip disclosed by the invention is arranged by adopting a preset dot matrix, and detection is realized through sample total DNA extraction, multiple PCR amplification and biotin labeling, chip hybridization, washing, sealing, enzyme labeling, color development and scanning interpretation; the method can realize synchronous detection of 12 target bacteria, and has good specificity, repeatability and application value.
Resumen de: WO2024025312A1
The present invention relates to a recombinant expression vector for secretion of IFN-β proteins and an attenuated Salmonella strain transformed by means of same, and provides: a recombinant expression vector comprising flgM genes, IFN-β genes, and flhDC genes; an attenuated Salmonella strain transformed by means of same; and a pharmaceutical composition for cancer treatment comprising the attenuated Salmonella strain as an active ingredient.
Resumen de: EP4279503A1
0001 Provided is a method that enables the presence and/or amount of bacteria of Enterobacteriaceae in a food/drink sample, an environmental sample, or a biological sample to be detected easily and efficiently in a short amount of time. Said method includes a step for simultaneously detecting, on the basis of an antigen-antibody reaction, the presence and/or amount of bacteria of Enterobacteriaceae of at least two different genera in a sample.
Resumen de: CN122212224A
The invention discloses preparation of feed-grade high-specific-surface-area nano zinc oxide and application of the feed-grade high-specific-surface-area nano zinc oxide to piglets. Crude zinc oxide is adopted as a raw material, and the zinc oxide is prepared through the processes of ammonia leaching, ammonia distillation, calcination and the like. The feed-grade high-specific-surface-area nano zinc oxide prepared by the method has the specific surface area of more than 60m < 2 >/g, the ZnO content of more than 95%, the particle size of less than 100nm, the average particle size of 50-100nm, the content of harmful element lead of less than 10mg/kg, the arsenic content of less than 3mg/kg and the cadmium content of less than 8mg/kg. Compared with common nano-zinc oxide (OZO), the nano-zinc oxide has better stability in simulated piglet gastrointestinal fluid, has better bacteriostatic activity on escherichia coli K88, staphylococcus aureus and salmonella suis, has smaller toxicity on a pig small intestine epithelial cell line IPEC-J2, can significantly reduce cell apoptosis and generation of active oxygen in cells, and can be used for preparing the antibacterial nano-zinc oxide. 150mg/kg of the feed additive is added into daily ration of the first two weeks after weaning of the piglets to reduce the diarrhea of the weaned piglets, improve the average daily gain of the piglets and reduce the feed-gain ratio, and the feed additive has a good effect.
Resumen de: CN122214196A
The invention relates to a strain of WZ-93 for relieving constipation and application thereof, the preservation number of the WZ-93 is CGMCC No.37033, and the WZ-93 has antibacterial activity on Escherichia coli, salmonella enteritidis and staphylococcus aureus, and can be used for treating constipation. The compound can be copolymerized with Escherichia coli, Salmonella enteritidis, Staphylococcus aureus, Streptococcus parablood, Enterobacter cloacae and Isostercas verbena, can grow and propagate by using oligosaccharide or D-psicose as a carbon source, can reduce secretion of inhibitory peptide neurotransmitters, can promote generation of excitatory peptide neurotransmitters, can promote secretion of anti-inflammatory factors, and can be used for preparing anti-inflammatory drugs. The composition can inhibit the secretion of proinflammatory factors, can enhance the intestinal peristalsis function, reduce the first black excrement discharge time, increase the excrement water content, improve the alpha-diversity of intestinal flora, promote the proliferation of beneficial bacteria and reduce the abundance of harmful bacteria, and can be used for preparing preparations or products for relieving constipation and preventing pathogenic bacterium infection.
Nº publicación: CN122214382A 16/06/2026
Solicitante:
GUANGZHOU HUAJIN PHARMACEUTICAL TECH CO LTD
GUANGDONG YUEGANG AODAWAN COLLABORATIVE INNOVATION RESEARCH INST
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\u5E7F\u4E1C\u7CA4\u6E2F\u6FB3\u5927\u6E7E\u533A\u534F\u540C\u521B\u65B0\u7814\u7A76\u9662
Resumen de: CN122214382A
The invention discloses an application of serine and glycine depletion engineering bacteria targeting soft tissue sarcoma, which comprises the steps of construction and identification of engineering bacteria SGS1, in-vitro experimental verification, material screening and preparation, and construction and identification, during use, screening and preparation of vector bacteria: selecting attenuated salmonella typhimurium VNP20009 as the vector bacteria, and screening and preparing the vector bacteria by using the attenuated salmonella typhimurium VNP20009 as the vector bacteria; the strain has high tumor enrichment, is purified by a centrifugal washing method after being subjected to sterile culture amplification, impurities and infectious microbes in a culture medium are removed for later use, a serine dehydratase gene from pseudomonas is selected, a target gene segment is obtained through a PCR amplification technology, and after the correctness of the segment size is verified through agarose gel electrophoresis, the target gene is recovered for later use. A secretory vector and a tumor microenvironment responsive promoter are selected, the secretory vector is subjected to enzyme digestion treatment, so that the vector has a site connected with a target gene, and meanwhile, the tumor microenvironment responsive promoter can specifically promote the expression of the target gene in a tumor microenvironment for later use.
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