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97
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Resultados 25 a 50 de 97
Resumen de: CN122081185A
本发明属于生物医药技术领域，公开了一种用于肿瘤原位表达微管抑制蛋白的工程化细菌及其应用。通过将微管抑制蛋白基因构建至表达载体，最终转入细菌，形成工程菌。该工程菌能靶向定植于肿瘤微环境，表达微管抑制蛋白，有效抑制肿瘤细胞，显著抑制实体瘤生长，且安全性优良。
Resumen de: CN122084896A
本发明公开了油脂饲料添加剂中沙门氏菌的快速筛查定量检测方法，涉及饲料添加剂检测技术领域，所述检测方法包括以下步骤：基质兼容化预处理；选择性亲和富集：快速筛查通道以及定量通道；内参与矩阵响应校准。本发明通过可逆性脂质屏蔽的基质兼容化预处理，降低油脂对捕获层与检测反应的界面干扰，克服高油脂基质中游离油脂导致的抗体配体位点遮蔽、试剂吸附以及核酸酶反应抑制等问题，避免单纯强烈化学去脂带来的目标标志破坏或检测失效，在不损伤目标识别位点的前提下显著改善下游捕获与检测灵敏度，提高样品兼容性并缩短现场前处理的复杂度，利于快速质检流程落地。
Resumen de: CN122084894A
本发明公开了基于3D打印的便携按压式磁弹微生物传感器、制备方法及检测方法，属于生物传感器技术领域；传感器包括壳体、传感芯片、检测线圈、信号采集模块；壳体内设置有气泵腔体、微通道、反应腔；传感芯片内嵌于反应腔，检测线圈环绕于反应腔外侧并与信号采集模块电连接；微通道一端与气泵腔体连通，另一端与反应腔连通；微通道设置有外部取样接口；壳体采用3D打印技术制备，通过按压气泵腔体产生的压力驱动样本沿微通道进入反应腔，进而对污水样本进行检测；本发明解决了集成化与便携性问题，适配现场即时检测；全流程封闭化操作无需样本转移，检测数据可靠性有效提升。
Resumen de: CN122081240A
0001 本发明公开了一种沙门菌H:i抗原表位特异性单克隆抗体及其应用，其由保藏编号为CCTCC NO:C202645的杂交瘤细胞分泌得到，该抗体具有效价高、特异性强的优势。本发明以此抗体构建的阻断ELISA检测试剂盒及其检测方法可特异性检测感染动物血清中含H：i抗原表位沙门菌的抗体，且与不含H:i抗原表位沙门菌及非沙门菌的抗体均不反应，敏感性、特异性和稳定性良好，为鼠伤寒和肯塔基等含H:i抗原表位沙门菌感染的直接血清学检测提供了新方法。
Resumen de: CN118846069A
The invention relates to the field of medicine, in particular to a pharmaceutical composition and a preparation method and application thereof.The pharmaceutical composition comprises a first effective component, a second effective component and a pharmaceutically acceptable carrier or auxiliary material, the microbial agent comprises any one or more of staphylococcus aureus, bordetella pertussis, diphtheria toxoid, tetanus toxoid, typhoid bacillus or paratyphoid bacillus, and the second effective component comprises polyinosinic acid, polycytidylic acid and vitamin. The pharmaceutical composition belongs to artificial active immunotherapy aiming at tumors, can'stimulate 'the whole immune system, enables the therapy of activating the human immune system by bacteria to kill cancer cells to be quite stable and reliable, can remarkably save and prolong the life of cancer patients, has extremely high safety and extremely small toxic and side effects, and is suitable for clinical application. And the preparation cost is low.
Resumen de: CN122071681A
The invention discloses a recombinant engineering bacterium, a preparation method thereof and application of the recombinant engineering bacterium in preparation of antithrombotic drugs, and belongs to the technical field of biological medicines. The recombinant engineering bacterium is prepared by taking salmonella typhimurium with relA and spoT gene mutations as a carrier and introducing a recombinant plasmid containing a thrombolytic enzyme coding gene into the carrier. The invention provides a recombinant engineering bacterium with biological safety, the recombinant engineering bacterium has high thrombus targeting property under a dynamic blood flow condition, various thrombus models can be specifically targeted, and the concentration of the recombinant engineering bacterium in thrombus tissues can reach more than ten thousand times of the concentration of normal tissues such as spleen, liver and the like through bacterium proliferation. Through mediated thrombus targeted therapy, thrombus can be effectively dissolved, and revascularization is achieved. The invention provides a more effective and safer treatment strategy for diseases caused by thrombus, such as myocardial infarction, cerebral apoplexy, pulmonary embolism and the like.
Resumen de: US20260137765A1
A method of producing a monomer of a Shiga toxin B-subunit (STxB) protein or of a variant thereof by peptide chemical synthesis, as well as to a method of producing a pentamer of the STxB protein or of the variant thereof. The methods are particularly advantageous as they overcome major issues typically observed in peptide chemical synthesis, including solubility and purity issues.
Resumen de: AU2026203336A1
Outer membrane vesicles from bacteria of the Burkholderia pseudomallei complex can be used as adjuvants in compositions and methods to potentiate the immune response to immunogens. ay a y
Resumen de: US20260137738A1
The present invention relates to a novel bacteriophage OPT-SALO1 with specific killing ability for Salmonella enterica, an antibiotic composition comprising the bacteriophage, a composition for adding to a feed, a feed, a disinfectant or a cleaning agent, and a method for preventing or treating infectious diseases caused by Salmonella enterica comprising a step of administering the bacteriophage to a subject.
Resumen de: AU2026203393A1
DETOXIFIED LIPOPOLYSACCHARIDES (LPS), NATURALLY NON-TOXIC LPS, AND USES THEREOF The invention relates to an enriched population of modified lipopolysaccharide (LPS) molecular species being: - devoid of phosphate group at position C1 of the reducing end of their lipid A domain; and - substituted at position C6’ of the non-reducing end of their lipid A domain by a 10 hydrophilic moiety, with the proviso that said hydrophilic moiety is not a hydroxyl group. It also relates to compositions comprising the enriched population of modified LPS; and uses of naturally-occurring LPS molecular species and/or enriched population of modified LPS molecular species for treating and/or preventing cancer, inflammatory 15 diseases or infectious diseases, and for stimulating an immune response or vaccinating a subject. - 10 - ay a y - - 1
Resumen de: US20260140114A1
The disclosure provides methods, compositions, and kits for enhanced detection of microbes in samples and monitoring of antimicrobial activity in a subject.
Resumen de: US20260139012A1
A method for increasing the presentation of ETEC CS6 antigen on a cell surface, comprising the step of contacting cells expressing said antigen with an aqueous solution comprising 0.6-2.2 percent phenol by weight, such that the presentation of said antigen is increased by at least 100%. A method for the manufacture of a killed whole cell vaccine for immunization against CS6-expressing ETEC. Cells and vaccines obtainable by the above methods.
Resumen de: CN122063016A
The invention discloses an oil immersion lens microscopic imaging multi-target simultaneous detection platform based on machine vision and application, and belongs to the field of biochemical analysis. The aptamer is adopted as a recognition element and matched with the corresponding complementary DNA chain and the combined DNA chain, the aptamer and the DNA chain can be replaced according to a target object, operation is easy and convenient, good applicability and universality are achieved, the size of an observation area is reduced to the dry size of a liquid drop area from the size of a conventional cover glass, visual field loss is greatly reduced, and the detection accuracy is improved. The visual imaging of a single microsphere can be realized, the signal sensing is direct and efficient, and the detection sensitivity is high; the multi-detection capability of the color and particle size combination of the microspheres is strong; the used recognition elements are all DNA sequences, so that the use cost of the recognition elements such as antibodies can be greatly reduced.
Resumen de: WO2026098490A1
Disclosed in the present application is the use of Salmonella typhimurium-derived glutamate dehydrogenase and related biomaterials thereof in amino acid synthesis. Provided in the present application is the use of Salmonella typhimurium-derived glutamate dehydrogenase for improving the L-amino acid yield of a microorganism. In the present application, an optimized coding gene of the Salmonella typhimurium-derived glutamate dehydrogenase is further obtained by means of codon optimization, and the introduction of the optimized coding gene into a recipient microorganism can significantly improve the L-amino acid yield of the recipient microorganism.
Resumen de: CN122038605A
The invention relates to a primer probe group, a multiplex fluorescent quantitative PCR method and a kit for simultaneously detecting six pathogenic bacteria, and belongs to the technical field of molecular biology, the primer probe group comprises primer sequences and probe sequences shown in SEQ ID No.1-18 in a table 1; the 5'end of each probe sequence is modified with a reporter group, and the 3 'end of each probe sequence is modified with a quenching group; the reporter group is Cy5, FAM and VIC, and the quenching group is Eclipse. The invention provides a method for simultaneously detecting six pathogenic bacteria including vibrio parahaemolyticus, salmonella, staphylococcus aureus, escherichia coli O157: H7, listeria monocytogenes and shigella in the same reaction system by combining a multiple real-time fluorescent quantitative PCR (Polymerase Chain Reaction) technology. The multiplex real-time fluorescent quantitative PCR kit provided by the invention is used for detecting the six pathogenic bacteria, can improve the detection sensitivity and specificity, greatly improves the detection efficiency, and overcomes the defects of complex steps, long detection period and incapability of adapting to large-scale rapid detection in the conventional detection method.
Resumen de: CN122031718A
The invention relates to the technical field of nano material preparation and biological medicine, in particular to a combined medicine of attenuated salmonella loaded barium titanate piezoelectric nano particles and application. The combined medicine provided by the invention is barium titanate piezoelectric nano-particles which are modified by a silane coupling agent and have the characteristics of good surface charges and the like, and the barium titanate piezoelectric nano-particles are combined on the surface of attenuated salmonella through electrostatic interaction. The invention further provides a preparation method of the combined medicine. The preparation method comprises the following steps: step 1, preparing the barium titanate piezoelectric nano-particles with good surface charge and other characteristics; and step 2, preparing the attenuated salmonella loaded barium titanate piezoelectric nano-particle combined medicine. The invention further provides application of the combined medicine in the anti-tumor aspect. The combined medicine disclosed by the invention has good anti-tumor performance and excellent biological safety, and a new thought is provided for bacterium-nanoparticle combined treatment.
Resumen de: CN122038409A
The invention discloses a biosensor detection reagent for detecting salmonella typhimurium and a preparation method, and belongs to the technical field of biomedicine. According to the invention, a DNA sequence of an amino-modified nucleic acid aptamer for detecting salmonella typhimurium is screened out and is shown as SEQ ID No: 1. Based on the nucleic acid aptamer, amino modified aptamer-fluorescent nano-enzyme serving as an energy donor and sulfydryl modified aptamer-gold nanoparticles serving as an energy receptor are mixed according to the volume ratio of 1: 1, and the biosensor detection reagent is prepared. The linear detection range of the biosensor detection reagent on salmonella typhimurium is 101-107 CFU/mL, the linear correlation coefficient R2 is equal to 0.9981, and the detection limit is as low as 1.527 CFU/mL. The biosensor detection reagent disclosed by the invention still keeps good selectivity and stability in a complex environment with high protein, high fat and high salt, and is suitable for rapid field detection in the fields of food safety and medical diagnosis.
Resumen de: WO2026102349A1
Interleukin-23 receptor (IL23R) VHH antibodies are disclosed, as well as methods of making and using the same, e.g., for treatment of IL23-mediated diseases and disorders, including, e.g., gastrointestinal-related (Gl-related) diseases (e.g., inflammatory bowel disease (IBD) (e.g., ulcerative colitis (UC) or Crohn's disease (CD)), a colon cancer, a small intestine cancer, a gastric cancer, an irritable bowel syndrome, a gastrointestinal ulcer, a gut-associated infection (e.g., a Salmonella infection or a Clostridium difficile infection), celiac disease, or pathogenic inflammation).
Resumen de: CN122038223A
The invention provides clostridium butyricum pandaZhang, a microbial agent, a bacteriostatic agent and application of the clostridium butyricum pandaZhang, and belongs to the technical field of microorganisms. The preservation number of the clostridium butyricum pandaZhang is CCTCC (China Center for Type Culture Collection) NO: M 20253041. The clostridium butyricum pandaZhang is strong in antibacterial ability and wide in antibacterial spectrum, can generate antibacterial active substances such as lanheheptide through metabolism, and has a remarkable inhibition effect on various pathogenic bacteria such as escherichia coli, staphylococcus aureus, klebsiella pneumoniae, salmonella and proteus mirabilis. The strain has outstanding short-chain fatty acid production capacity, and can efficiently produce key metabolites such as propionic acid and butyric acid. When the strain is applied to breeding of weaned piglets, the growth performance of the piglets can be remarkably improved, the diarrhea rate of the weaned piglets is reduced, the intestinal health of the piglets is improved, and healthy and efficient breeding of the piglets under the antibiotic-free condition is achieved.
Resumen de: US20260131039A1
This disclosure relates to a method for sanitizing a space. The method includes applying a composition containing triethylene glycol into a space containing a pathogen (e.g., a Staphylococcus, a Pseudomonas, a Listeria, Salmonella, Klebsiella, a mycobacterium, a mold, or a spore) in an amount effective to inactivate the pathogen.
Resumen de: US20260132409A1
The present disclosure provides fusion proteins comprises fusion proteins comprising the signal sequence of PduB or PduM and a heterologous protein, as well as constructs for expressing the fusion proteins, and methods of their use. The fusion proteins are designed to deliver the heterologous proteins to bacterial microcompartments and modify the 1,2-propanediol metabolic pathway.
Resumen de: WO2018208840A1
Provided are novel methods for screening and testing for pathogens in food, water, and bodily fluids using methods that are faster to complete than conventional methods of culturing and plating that require lengthy times in properly equipped labs. The invention utilizes specific, rapid and sensitive optical detection to capture small concentrations of the target bacteria and render them amenable for detection with various specific synthesis binding agents approaches. The technique merges capture and detection steps with quantification unit suitable to provide results in a relatively shorter time current detection methods.
Resumen de: CN122012356A
The invention discloses a lactobacillus amyloliquefaciens and probiotic microbial inoculum and application of the lactobacillus amyloliquefaciens and probiotic microbial inoculum. The lactobacillus amyloporus is named as lactobacillus amyloporus YI39, and the preservation number of the lactobacillus amyloporus YI39 in the China Center for Type Culture Collection is CCTCC (China Center for Type Culture Collection) NO: M2026104; the nucleotide sequence of 16SrDNA (deoxyribonucleic acid) of the gene is SEQ ID NO. 1. The lactobacillus amyloliquefaciens YI39 provided by the invention is separated from ileum contents of 28-day-old healthy and rapid yellow-feathered broilers, has strong probiotic characteristics, and has relatively good capabilities of inhibiting growth of salmonella pullorum, avian pathogenic escherichia coli, A-type clostridium perfringens and staphylococcus aureus; the body of the broiler chicken can be effectively regulated and controlled, so that the chicken necrotic enteritis caused by clostridium perfringens infection is prevented.
Resumen de: CN122016744A
The invention provides a magnetic control ratio fluorescent biosensor based on RPA-CRISPR/Cas12a as well as a preparation method and application of the magnetic control ratio fluorescent biosensor, and belongs to the technical field of fluorescent biosensors and pathogenic bacterium detection. The magnetic control ratio fluorescence biosensor comprises a fluorescence reference signal element, a fluorescence response signal element and a specific recognition element, according to the magnetic control ratio fluorescent biosensor, high-sensitivity and specific detection of staphylococcus aureus and salmonella is realized through the magnetic and fluorescent characteristics of the fluorescent reference signal element, the fluorescent characteristic of the fluorescent response signal element and the nucleic acid cleavage activity of Cas12a; the magnetic control ratio fluorescent biosensor has a built-in calibration function, can reduce interference brought by the environment and instruments, has good selectivity to staphylococcus aureus and salmonella, has good anti-interference performance to other bacteria, and can be used for rapid detection in the field of food safety.
Nº publicación: CN122012415A 12/05/2026
Solicitante:
GUANGXI UNIV FOR NATIONALITIES
GUANGXI YUEMU BIOLOGICAL TECH CO LTD
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Resumen de: CN122012415A
The invention discloses a lytic salmonella pullorum bacteriophage and application thereof.The bacteriophage is provided with a polyhedral head and a contractile tail, the average diameter of the head is about 71 nm, the average diameter of the tail is about 126 nm, the bacteriophage belongs to the muscular tail bacteriophage family, and the bacteriophage can split 15 salmonella pullorum strains in 18 salmonella clinical isolates and can be used for treating salmonella pullorum. The incubation period is about 40 minutes, the cracking period is about 170 minutes, and the cracking amount reaches 142 PFU/cell. The lytic salmonella pullorum bacteriophage, the lytic salmonella pullorum bacteriophage and the separated bacteriophage have the advantages of wide host spectrum, high splitting efficiency, low optimal infection complex number, low production cost and the like, clinical tests show that the death rate of infected chickens can be remarkably reduced, the detection rate of salmonella in visceral organs is reduced, and the application prospect is wide. The salmonella pullorum prevention and control agent can effectively prevent and control salmonella pullorum, relieve pathological injuries, purify chicken flocks after long-term use, improve the laying rate and the laying quality, and provide a novel safe, efficient, economical and environment-friendly salmonella pullorum prevention and control scheme for poultry breeding industry.
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