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81
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Última actualización
14/08/2025 [07:13:00]
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Resumen de: US2025025552A1
The present invention provides methods and compositions for specific activation of inflammatory responses in dendritic cells (DCs). 1-palmitoyl-2-arachidonyl-sn-glycero-3-phosphorylcholine (PAPC) and its oxidized variant (oxPAPC) were identified to promote DC-mediated immunity, and are provided as adjuvants in immunostimulatory compositions, including vaccines.
Resumen de: CN120192426A
本发明涉及一种预防沙门氏菌感染的融合蛋白、免疫原性组合物、重组疫苗以及分子架构设计和应用等。本发明选取能够在真核细胞中顺利表达的PstS‑LpfB、PstS‑YidR、LpfB‑SinH三种融合蛋白设计进行动物免疫实验，验证保护效果。本发明发现PstS‑LpfB等融合蛋白分子可减弱沙门氏菌感染引起的组织病变，具有良好的免疫原性，起到有效预防和免疫保护作用，高效预防沙门氏菌感染，具有广泛的应用前景。
Resumen de: KR20250092807A
본 발명은 살모넬라 속(Salmonella spp.) 균주에 특이적인 사멸능을 갖는 신규한 박테리오파지 KFSST2 및 이를 포함하는 항균 조성물에 관한 것으로, 상기 박테리오파지 KFSST2는 살모넬라균을 특이적으로 사멸시키는 효과를 가지며 높은 특이성 및 우수한 용균 활성을 나타냄으로써, 항생용 조성물, 살모넬라균에 의한 감염성 질병의 예방 또는 치료용 조성물, 사료 첨가용 조성물, 소독제, 또는 세척제 분야에서 다양하게 사용될 수 있다. 또한, 상기 박테리오파지 KFSST2 또는 이를 포함하는 항생제를 제공함으로써, 항생제 내성균의 문제점, 식품 내의 항생제의 잔류 문제, 광범위한 숙주 범위의 문제점을 해결 할 수 있는 이점이 있다.
Resumen de: US2025195631A1
To make an immunotherapy that is effective for a larger group of cancer patients, Salmonella have been genetically engineered to deliver proteins from prior vaccines into the cytoplasm of tumor cells.
Resumen de: US2025195635A1
A method of generating a Salmonella free egg is disclosed. The method includes administering a vaccination to a poultry animal that is less than one year old. The method further includes boosting the vaccination of the poultry animal when the poultry animal is between about 50 weeks old and about 60 weeks old, the boosting comprising administering killed virus if the poultry animal molted subsequent to the vaccination, and the boosting comprising administering live virus if the poultry animal did not molt subsequent to the vaccination at the time of boosting.
Resumen de: US2025197951A1
This disclosure relates to methods of isolating rare or non-dominant serotypes of Salmonella species from a sample. The disclosure further relates to the isolation of non-dominant serotypes of Salmonella in a sample related to one or more products for human or animal consumption.
Resumen de: AU2023323947A1
The invention is directed to immunogenic compositions and method of treatment comprising a peptide or nucleic acid that encodes the peptide that induces an immune response in a mammal that is protective against infection by one or more pathogens. The peptide sequence contains multiple epitopes, wherein at least one epitope is a composite epitope which is a combination of two or more conserved epitopes of the pathogen wherein the amino acid sequence of the composite is not an amino acid sequence of the pathogen. In addition, the invention is directed to vaccines comprising the peptide or nucleic acid that encodes the peptide for treating and preventing an infection in mammals such as animals and humans.
Resumen de: US2025025552A1
The present invention provides methods and compositions for specific activation of inflammatory responses in dendritic cells (DCs). 1-palmitoyl-2-arachidonyl-sn-glycero-3-phosphorylcholine (PAPC) and its oxidized variant (oxPAPC) were identified to promote DC-mediated immunity, and are provided as adjuvants in immunostimulatory compositions, including vaccines.
Resumen de: WO2025122955A1
Provided herein are methods and compositions for treating cancer. One composition includes an engineered bacterial cell comprising: a) a lysis gene or lysis cassette operably linked to an intracellularly induced Salmonella promoter; b) one or more of the bacterial cell genes selected from the group consisting of recA, recB, recF, sbcB, sbcCD, red, sseJ or any combination thereof are knocked out; and c) a nucleic acid sequence coding for an oncolytic virus genome.
Resumen de: WO2024155027A1
The present invention relates to an attenuated Salmonella gallinarum expressing FliC or FliC-hiL2 and use thereof. The Salmonella strain according to the present invention has excellent immune activity and exhibits excellent anti-cancer efficacy, and thus can be used as a therapeutic agent for cancer together with or independently of existing anti-cancer drugs.
Resumen de: CN120118166A
本发明通过筛选、实验验证获得一段能够代表沙门氏菌作为抗原的特异性蛋白片段，以这一段特异性蛋白片段作为抗原免疫小鼠，利用细胞融合技术得到可以稳定分泌单克隆抗体的杂交瘤细胞，最终制备了效价高、特异性好的抗沙门氏菌单克隆抗体。同样以该特异性蛋白片段免疫兔子，获得了抗沙门氏菌多克隆抗体。基于鼠单克隆抗体和兔多克隆抗体，建立沙门氏菌胶体金免疫层析检测方法，该检测方法特异性良好，为食品中沙门氏菌的检测提供了快速、简便的检测手段。
Resumen de: CN120098782A
The invention relates to the technical field of microbiological detection, and particularly discloses a microfluidic device for detecting salmonella and a detection method.The microfluidic device comprises a top cover, a functional plate and a heating base which are detachably connected in sequence from top to bottom; an observation window, a first sample adding opening and a second sample adding opening are formed in the top cover; a detection bin is formed in a position, corresponding to the observation window, on the function plate; an amplification bin communicated with the second sample adding opening is formed in the functional plate; a buffer bin communicated with the first sample adding opening is formed in the functional plate; the amplification bin is communicated with the buffer bin, the buffer bin is communicated with the detection bin, and a space for placing a test strip is reserved in the detection bin; a ventilation channel is further formed in the function plate and communicates with the amplification bin. The micro-fluidic device provided by the invention is simple in structure, convenient to carry, easy to interpret a detection result and simple in operation mode, and meanwhile, in combination with the design of the micro-fluidic device, the nucleic acid detection does not need additional equipment and complicated manual intervention.
Resumen de: CN120098102A
The invention relates to the technical field of biology, in particular to an antibacterial peptide Clavanin A-1, a coding gene and application of the antibacterial peptide Clavanin A-1. The invention provides an antibacterial peptide Clavanin A-1 which has good thermal stability, acid-base stability and endogenous protease degradation resistance, can obviously inhibit the growth of escherichia coli, salmonella and staphylococcus aureus, and has good application prospects in the fields of food, hygienic products, cosmetics, biopesticide, biological feed additives or natural food preservatives and the like. Wide application prospects are realized.
Resumen de: CN120098081A
The invention belongs to the technical field of biology, and relates to a narrow-spectrum antibacterial peptide XMK-8 and application thereof. The amino acid sequence of the narrow-spectrum antibacterial peptide XMK-8 is as shown in SEQ ID NO: 1, and the narrow-spectrum antibacterial peptide XMK-8 has no bacteriostatic activity on escherichia coli, salmonella, staphylococcus aureus and aeromonas hydrophila and only has bacteriostatic activity on pasteurella multocida and haemophilus parasuis. The antibacterial activity of the narrow-spectrum antibacterial peptide XMK-8 can still be detected after treatment with salt ions (sodium ions and potassium ions, 50-200 mmol/L), acid-base (pH 4-10) and protease K (20-100 mu g/mL) at the temperature of 0-100 DEG C, and the narrow-spectrum antibacterial peptide XMK-8 has low hemolytic activity on red blood cells of mice. The antibacterial peptide XMK-8 disclosed by the invention is expected to become a novel antibiotic substitute and has a good application prospect in prevention, treatment, diagnosis and identification of pasteurella multocida, haemophilus parasuis and infection thereof.
Resumen de: CN120093643A
The invention discloses multi-effect talcum powder for animals as well as a preparation method and application of the multi-effect talcum powder. The multi-effect talcum powder comprises the following components in percentage by mass: 1-3% of sodium benzoate, 1-3% of glycerol monolaurate, 0.5-1.5% of tea polyphenol, 7-13% of citric acid, 15-25% of corn fiber powder and 54.5-75.5% of diatomite. The talcum powder does not stick to the body, is easy to fall off, has good moisture absorption and drying effects, can improve a humid environment and adsorb odor, is good in acidic stability, has an inactivation effect on escherichia coli, salmonella, staphylococcus aureus and porcine rotavirus, and is safe, non-toxic, free of drug resistance, low in cost and stable in performance when being applied to a livestock and poultry breeding environment.
Resumen de: CN120102874A
The invention belongs to the field of salmonella detection, and discloses a fluorescent lateral flow chromatography detection method for detecting salmonella, which realizes sensitive detection of salmonella through combination of CsPbBr3 (at) SiO2 with excellent fluorescence performance and Fe3O4 with magnetic response capability. The problems that in the prior art, real-time on-site antibody detection is long in time consumption, labor-consuming, high in cost, unable to quantify and the like are solved. The fluorescent probe IPNs capable of specifically recognizing salmonella is obtained by coating the outside of perovskite quantum dots with silicon dioxide, and meanwhile, the surfaces of Fe3O4 nanoparticles are modified with salmonella antibodies to prepare the magnetic probe IMNs. The former provides a fluorescence signal, and the latter realizes rapid separation of bacteria, so that the detection is more sensitive, rapid and convenient, and is suitable for various scenes. Human eyes are highly sensitive to green fluorescence, preliminary qualitative detection can be realized without a fluorescence detector, the method is suitable for field detection, and the method is excellent in specificity, anti-interference capability and repeatability and has potential in actual detection.
Resumen de: US2025177534A1
This invention describes method for inactivation of microorganisms in thermostable dry formulations at ambient temperatures (AT) using UV light irradiation. According to this method microorganisms are inactivated at ambient temperatures (AT) in dry formulations where the amount of free radicals formed is relatively small and damage of nucleic acids is the main cause for the microorganism's death. The method will allow production of thermostable inactivated vaccines from wild type and live attenuated microorganisms, thermostable inactivated microbiome products, and thermostable sterilized none-live blood components, therapeutic proteins, antibodies and other fragile biopharmaceuticals.
Resumen de: US2025177508A1
Described is a method for the generation of a live vaccine containing stable bacteria carrying at least three attenuating mutations and a vaccine containing bacteria obtained by said method.
Resumen de: AU2023312737A1
Provided herein are vaccine composition comprising a
Resumen de: CN120081916A
本发明公开了一种鼠伤寒沙门菌特异性抗原片段及其在检测鼠伤寒沙门菌抗体中的应用。所述鼠伤寒沙门菌特异性抗原片段的氨基酸序列如SEQ ID NO.1所示。本发明首次公开了以鼠伤寒沙门菌特异性抗原片段作为间接ELISA的包被抗原，建立了鼠伤寒沙门菌间接ELISA抗体检测方法，鼠伤寒沙门菌特异性抗原片段含有鼠伤寒沙门菌FliC蛋白的优势B细胞表位，能够特异性识别诱导产生的鼠伤寒沙门菌FliC蛋白抗体，在提高抗原抗体特异性结合方面有显著性的增效作用。本发明能够用于鼠伤寒沙门菌抗体的检测，为鼠伤寒沙门菌的流行病学调查以及沙门菌的防控提供了有力的技术支持。
Resumen de: CN120082456A
The invention provides bacillus coagulans and application thereof, relates to the technical field of microorganisms, and aims to solve the problem that a biological material with a strong antibacterial function and good tolerance is lacked in the prior art. The invention provides bacillus coagulans XH-2, the preservation number of the bacillus coagulans XH-2 is CCTCC NO: M 2023759, the bacillus coagulans XH-2 is preserved in the China Center for Type Culture Collection on May 15, 2023, and the preservation address is Wuhan University, China. The bacillus coagulans XH-2 disclosed by the invention has a relatively strong inhibition effect on escherichia coli, and also has a relatively good inhibition effect on salmonella gallinarum, salmonella suis and salmonella typhimurium at the same time. According to the invention, the bacillus coagulans XH-2 is used as an active ingredient to prepare the livestock or poultry feed additive, and the strain has strong gastric juice and cholate tolerance, and can inhibit the growth of pathogenic bacteria and improve the conversion and utilization of animal feed.
Resumen de: CN120082663A
The invention relates to the technical field of microbiological detection, and particularly discloses a primer probe combination for detecting six food-borne pathogens and application of the primer probe combination. The detection primer probe combination for the six food-borne pathogens comprises six pairs of specific primer pairs and six probes, the nucleotide sequences of the specific primer pairs are respectively shown as SEQ ID NO.1, SEQ ID NO.4, SEQ ID NO.8, SEQ ID NO.1, SEQ ID NO.13, SEQ ID NO.16, SEQ ID NO.19, SEQ ID NO.22, SEQ ID NO.26, SEQ ID NO.29, SEQ ID NO.32 and SEQ ID NO.35, and the nucleotide sequences of the probes are respectively shown as SEQ ID NO.37-SEQ ID NO.42; the six food-borne pathogens comprise listeria monocytogenes, salmonella, vibrio parahaemolyticus, norovirus, escherichia coli O157: H7 and staphylococcus aureus. According to the present invention, the pathogens of six common food-borne diseases can be detected, the detection method has characteristics of high specificity and high sensitivity, and the pathogens do not interfere with each other and do not inhibit each other during the detection so as to achieve good stability.
Resumen de: CN120053424A
The invention belongs to the technical field of anti-infection drugs, and particularly relates to medical application of apigenin in preparation of a salmonella flagellum inhibitor. A migration inhibition test (0.3% agar), minimum inhibitory concentration (MIC) determination, a Caco-2 cell adhesion test and a molecular docking test prove that the apigenin can specifically inhibit salmonella flagellum-mediated migration ability (inhibition rate gt; 49%) and host cell adhesion capability (reduced by more than or equal to 58%), and does not affect bacterial growth (pgt; 0.05), the apigenin can be used for targeting flagellin FljB, FliC, FlgN, FlgA and FlgG (binding energy per lt; -5kcal/mol) can block flagellar movement, and has an application prospect in prevention and control of livestock salmonella related diseases.
Resumen de: NZ752690A
An extract of an herbal composition comprising at least two different dried plants useful as antimicrobial and/or antibiofilm agent in the treatment or prevention of microbial infections caused by bacteria, such as for example Escherichia, Klebsiella, Listeria, Pseudomonas, Salmonella, Streptococcus or Staphylococcus, or by fungi, such as for example is herein described. It has been found that in such extract, the active ingredients exert their biological effects in a synergistic manner. The extract may constitute the active ingredient of a food supplement, a nutraceutical, pharmaceutical or cosmetic composition or a functional food or a food additive. A process for preparing said extract is also described here.
Nº publicación: CN120064644A 30/05/2025
Solicitante:
CHINA INST OF VETERINARY DRUGS CONTROL
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Resumen de: CN120064644A
The invention discloses a high-specificity pullorum disease salmonella gallinarum plate agglutination antigen preparation process, which comprises the following steps: respectively resuscitating pullorum disease salmonella C79-1 and C79-7 strains to prepare seed solutions, inoculating a suitable culture medium, carrying out fermentation culture according to a specific process, carrying out centrifugal collection on thalli after inactivation, and carrying out freeze drying to obtain the high-specificity pullorum disease salmonella gallinarum plate agglutination antigen. The preparation method comprises the following steps: carrying out high pressure at 121 DEG C for 2 hours, washing for multiple times, removing protein antigen components which are easily subjected to cross reaction with escherichia coli or enterobacteriaceae bacteria which are commonly used in other environments, adjusting the C79-1 strain and the C79-7 strain to proper bacterium concentration, adding Tween-20, crystal violet and glycerol, and fully homogenizing to obtain the salmonella typhimurium plate agglutination antigen for pullorum disease. The antigen has higher specificity, and is more accurate when being used for purifying and detecting the pullorum disease; according to the fermentation process, the bacterial yield is 4 times of that of common fermentation and 2 times of that of solid culture, ethanol precipitation is not needed, and the production cost is lower; tween-20 is added, so that the surfa
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