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ガスダーミンDに対するシングルドメイン抗体およびその使用

NºPublicación:  JP2026508175A 10/03/2026
Solicitante: 
ライニッシュフリードリッヒ-ウィルヘルムズ-ユニバーシタットボン
JP_2026508175_A

Resumen de: EP1000000A1

The invention relates to an apparatus (1) for manufacturing green bricks from clay for the brick manufacturing industry, comprising a circulating conveyor (3) carrying mould containers combined to mould container parts (4), a reservoir (5) for clay arranged above the mould containers, means for carrying clay out of the reservoir (5) into the mould containers, means (9) for pressing and trimming clay in the mould containers, means (11) for supplying and placing take-off plates for the green bricks (13) and means for discharging green bricks released from the mould containers, characterized in that the apparatus further comprises means (22) for moving the mould container parts (4) filled with green bricks such that a protruding edge is formed on at least one side of the green bricks.

β-连环蛋白贮库检测和调节测定

NºPublicación:  CN121620701A 06/03/2026
Solicitante: 
露点治疗公司
CN_121620701_PA

Resumen de: US2018099049A1

Stable lyophilized therapeutic protein compositions and their methods of manufacture are provided. Specifically, the use of water as a solid cake plasticizer and protein stabilizer is described. Also, the inclusion of a multicomponent stabilizer comprising a larger molecular entity and a smaller molecular entity is described. Also, the inclusion of post-drying annealing under certain conditions improves protein stability. Proteins are predicted to remain stable over 24 months at 25° C.

阿尔茨海默病的诊断和治疗方法

NºPublicación:  CN121620700A 06/03/2026
Solicitante: 
分子优公司
CN_121620700_PA

Resumen de: AU2024276342A1

Provided herein is a method for diagnosing and treating Alzheimer's disease comprising: (a) providing a biological sample obtained from the subject; (b) measuring concentration levels from the obtained sample, at least one, at least two, at least three, at least four or at least five Alzheimer's-related metabolites described herein and/or at least one, at least two, at least three, at least four or at least five Alzheimer's-related proteins described herein; (c) comparing the concentration levels of the Alzheimer's-related metabolites and/or proteins from the obtained sample to the concentration levels of corresponding reference Alzheimer's-related metabolites and/or proteins from an Alzheimer's- negative sample; (d) identifying the subject as having Alzheimer's if the concentration levels of the Alzheimer's-related metabolites and/or proteins from the obtained sample are different relative to the concentration levels of the reference Alzheimer's-related metabolites and/or proteins from the Alzheimer's-negative sample; and (e) treating or causing treatment of the subject.

一种黏度响应型荧光探针、制备方法及其应用

NºPublicación:  CN121609669A 06/03/2026
Solicitante: 
陕西省人民医院(陕西省临床医学研究院)
CN_121609669_PA

Resumen de: EP1000000A1

The invention relates to an apparatus (1) for manufacturing green bricks from clay for the brick manufacturing industry, comprising a circulating conveyor (3) carrying mould containers combined to mould container parts (4), a reservoir (5) for clay arranged above the mould containers, means for carrying clay out of the reservoir (5) into the mould containers, means (9) for pressing and trimming clay in the mould containers, means (11) for supplying and placing take-off plates for the green bricks (13) and means for discharging green bricks released from the mould containers, characterized in that the apparatus further comprises means (22) for moving the mould container parts (4) filled with green bricks such that a protruding edge is formed on at least one side of the green bricks.

一种超敏阿尔茨海默症血液诊断试剂盒及其检测方法

NºPublicación:  CN121613109A 06/03/2026
Solicitante: 
浙江欧赛思生物科技有限公司
CN_121613109_PA

Resumen de: EP1000000A1

The invention relates to an apparatus (1) for manufacturing green bricks from clay for the brick manufacturing industry, comprising a circulating conveyor (3) carrying mould containers combined to mould container parts (4), a reservoir (5) for clay arranged above the mould containers, means for carrying clay out of the reservoir (5) into the mould containers, means (9) for pressing and trimming clay in the mould containers, means (11) for supplying and placing take-off plates for the green bricks (13) and means for discharging green bricks released from the mould containers, characterized in that the apparatus further comprises means (22) for moving the mould container parts (4) filled with green bricks such that a protruding edge is formed on at least one side of the green bricks.

Fos Composition for inhibiting Fos transcription factor comprising as an active ingredient an extract of Jakyakgamchotang or a compound derived from the extract of Jakyakgamchotang

NºPublicación:  KR20260030219A 06/03/2026
Solicitante: 
한국한의학연구원
KR_20260030219_PA

Resumen de: EP1000000A1

The invention relates to an apparatus (1) for manufacturing green bricks from clay for the brick manufacturing industry, comprising a circulating conveyor (3) carrying mould containers combined to mould container parts (4), a reservoir (5) for clay arranged above the mould containers, means for carrying clay out of the reservoir (5) into the mould containers, means (9) for pressing and trimming clay in the mould containers, means (11) for supplying and placing take-off plates for the green bricks (13) and means for discharging green bricks released from the mould containers, characterized in that the apparatus further comprises means (22) for moving the mould container parts (4) filled with green bricks such that a protruding edge is formed on at least one side of the green bricks.

制御性T細胞表面抗原のエピトープおよびこれに特異的に結合する抗体

NºPublicación:  JP2026507922A 06/03/2026
Solicitante: 
グッドティーセルズ、インコーポレイテッド
JP_2026507922_PA

Resumen de: WO2024263939A1

The present disclosure relates method of identifying a compound targeting a first protein and a second protein, wherein the first protein and/or the second protein are associated with a disease or disorder.

MAGNETIC FORMULATIONS FOR BIOMARKER SAMPLING AND ENHANCED DRUG DELIVERY

NºPublicación:  US20260061081A1 05/03/2026
Solicitante: 
ROCKET SCIENCE HEALTH CORP [CA]
Rocket Science Health Corp
US_20260061081_PA

Resumen de: US20260061081A1

The present disclosure describes formulations, methods, and devices tor biomarker sampling and therapeutic delivery using magnetic formulations. When combined with the application of external magnetic fields, magnetic formulations move within the nasal cavity. Magnetic formulations provide benefits including the ability to: target or steer placement of the formulations via a magnetic field, enhance mixing of the formulation via a magnetic field, enhance biological material collection via antibody-coated magnetic beads, or enhance sample retrieval via a magnetic-tipped inserter. Example biological materials for collection include proteins, enzymes, neural stem cells, and other biomarkers.

Method for the prediction of a risk or severity of side effects in a cancer patient that is to be treated or has been treated with immune effector cell therapy (IECT)

NºPublicación:  US20260063648A1 05/03/2026
Solicitante: 
PAM THERAGNOSTICS GMBH [DE]
US_20260063648_PA

Resumen de: US20260063648A1

0000 The present application is directed to a method for the prediction of a risk of side effects and/or prediction of the severity of side effects in a cancer patient that is to be treated or has been treated with immune effector cells in the frame of an immune effector cell therapy (IECT), and/or for assessing an effect of a treatment of side effects in a cancer patient that has been treated with immune effector cells in the frame of an IECT, the method comprising the steps of a) determining the level of at least one endothelial dysfunction biomarker in a sample of bodily fluid of the patient, and b) correlating the level of the at least one endothelial dysfunction biomarker in the sample to the risk of the side effects and/or the severity of the side effects in the patient and/or to the effect of the treatment of the side effects in the patient. Further aspects relate to corresponding methods stratification and medicaments for use in corresponding treatment.

METHODS OF TREATING A COGNITIVE IMPAIRMENT

NºPublicación:  AU2024345495A1 05/03/2026
Solicitante: 
GRIFOLS WORLDWIDE OPERATIONS LTD
GRIFOLS WORLDWIDE OPERATIONS LIMITED
AU_2024345495_A1

Resumen de: AU2024345495A1

The disclosure pertains to treating a cognitive impairment, for example, an aging-associated cognitive impairment. In certain aspects, the disclosure describes methods of assaying a sample obtained from a subject having or suspected of having a cognitive impairment for one or more proteins selected from: DLL1, VNN2, VAV3, and SUMF1. In certain embodiments, the cognitive impairment is caused by a neurodegenerative disease, such as Alzheimer's disease. The methods further comprise identifying a subject as likely or not likely to respond positively to the plasma exchange therapy. In even further aspects, the disclosure describes methods for treating a cognitive impairment in the subject by a plasma exchange therapy, wherein based on the specific protein expression data, the subject is identified as likely or not likely to respond positively to the plasma exchange therapy. The plasma exchange therapy can be full and/or low volume plasma exchange. Also provided are kits suitable for performing the methods disclosed herein.

COMPOSITIONS AND METHODS FOR PROPHYLAXIS AND/OR TREATMENT OF AMYLOID B PEPTIDE PROTEINOPENIA IN ALZHEIMER'S AND OTHER DISEASES

NºPublicación:  AU2024325238A1 05/03/2026
Solicitante: 
LVIS REGAIN LP
LVIS-REGAIN LP
AU_2024325238_PA

Resumen de: AU2024325238A1

Material compositions and/or methods useful for the prophylaxis and/or treatment of protein depletion (proteinopenia) are provided, including material compositions that retains native function of a peptide/protein while limiting and/or preventing amyloid formation and/or aggregation of said peptide/protein. Material compositions and formulations for enhancing peptide/protein solubility, stability, circulation time, receptor interaction, brain penetrance, CSF half-life, facilitating peptide/protein synthesis and purification are also provided.

Biomarkers For A Systemic Lupus Erythematosus (SLE) Disease Activity Immune Index That Characterizes Disease Activity

NºPublicación:  US20260063632A1 05/03/2026
Solicitante: 
OKLAHOMA MED RES FOUND [US]
US_20260063632_PA

Resumen de: US20260063632A1

The present invention includes a method of characterizing disease activity in a systemic lupus erythematosus patient (SEE), comprising: obtaining a dataset associated with a blood, serum, plasma or urine sample from the patient, wherein the dataset comprises data representing the level of one or more biomarkers in the blood, serum, plasma or urine sample from each of (b) to (g); at least one innate serum or plasma mediator biomarker; at least one adaptive serum or plasma mediator; at least one chemokine/adhesion molecule biomarker; at least one soluble TNF superfamily biomarker; the inflammatory mediator biomarker SCF; at least one SLE-associated autoantibody specificity biomarker; and calculating a Lupus Disease Activity Immune.

METHODS AND ASSAYS FOR MODULATING GENE TRANSCRIPTION BY MODULATING CONDENSATES

NºPublicación:  KR20260030170A 05/03/2026
Solicitante: 
화이트헤드인스티튜트포바이오메디칼리서치메사추세츠인스티튜트오브테크놀로지
KR_20260030170_PA

Resumen de: EP1000000A1

The invention relates to an apparatus (1) for manufacturing green bricks from clay for the brick manufacturing industry, comprising a circulating conveyor (3) carrying mould containers combined to mould container parts (4), a reservoir (5) for clay arranged above the mould containers, means for carrying clay out of the reservoir (5) into the mould containers, means (9) for pressing and trimming clay in the mould containers, means (11) for supplying and placing take-off plates for the green bricks (13) and means for discharging green bricks released from the mould containers, characterized in that the apparatus further comprises means (22) for moving the mould container parts (4) filled with green bricks such that a protruding edge is formed on at least one side of the green bricks.

단백질, RNA, 또는 DNA 상호 작용에 대한 화합물의 영향을 검출하는 방법 및 도구

NºPublicación:  KR20260030055A 05/03/2026
Solicitante: 
IKTOS [FR]
UNIV DEVRY VAL DESSONNE [FR]
INST NAT SANTE RECH MED [FR]
\uC774\uD06C\uD1A0\uC2A4
\uC704\uB2C8\uBCA0\uB974\uC528\uB5BC \uB370\uBE0C\uB9AC \uBC1C \uB370\uC3DC\uB290
\uC778\uC384\uB984 (\uC5E5\uC2A4\uB760\uB6F0 \uB098\uC528\uC624\uB0A0 \uB4DC \uB77C \uC30D\uB5BC \uC5D0 \uB4DC \uB77C \uD750\uC250\uB974\uC288 \uBA54\uB514\uAE54)
KR_20260030055_PA

Resumen de: EP4459287A1

The present invention covers an in vitro method for evaluating the ability of a compound to disrupt or stabilize an interaction between one or more bait and one or more candidate prey in a eukaryotic cell. In addition, the present invention covers compounds identified by the in vitro method according to any one of the preceding claims, for use as a medicament.

CIRCULATING BIOMARKER LEVELS FOR DIAGNOSIS AND RISK-STRATIFICATION OF TRAUMATIC BRAIN INJURY

NºPublicación:  US20260063646A1 05/03/2026
Solicitante: 
BRAINBOX SOLUTIONS INC [US]
US_20260063646_PA

Resumen de: US20260063646A1

Methods, compositions and kits useful in the diagnosis, prognosis and/or assessment of brain injuries and risk for brain injuries, such as hemorrhage, are based upon detection of certain biomarkers.

COMPOSITION FOR MICROGLIAL REJUVENATION

NºPublicación:  WO2026049217A1 05/03/2026
Solicitante: 
UNIV CHA IND ACAD COOP FOUND [KR]
SUNGKWANG MEDICAL FOUND [KR]
\uCC28\uC758\uACFC\uD559\uB300\uD559\uAD50 \uC0B0\uD559\uD611\uB825\uB2E8
\uC758\uB8CC\uBC95\uC778 \uC131\uAD11\uC758\uB8CC\uC7AC\uB2E8
WO_2026049217_PA

Resumen de: WO2026049217A1

A composition for microglial rejuvenation according to an aspect, in which the composition comprises, as an active ingredient, an expression of an ACE protein or a gene inhibitor encoding same, rejuvenates microglia rather than suppresses neuroinflammatory responses in order to treat, prevent, or alleviate brain aging-related diseases. Accordingly, the composition is expected to be widely used in the treatment of most brain aging-related diseases for which existing neuroinflammatory response suppression strategies have failed.

Methods for Assaying a Bodily Sample of a Subject

NºPublicación:  US20260063642A1 05/03/2026
Solicitante: 
AGENT S A S [FR]
US_20260063642_PA

Resumen de: US20260063642A1

0000 In an aspect, the present disclosure provides a method comprising: (a) obtaining a bodily sample from a subject; and (b) assaying the bodily sample to determine a level of analytes in the sample, wherein the analytes comprise nucleic acids, proteins, or metabolites.

STEREOINVERSION METHOD FOR CELL-TYPE SPECIFIC LABELLING OF AMINO-ACIDS AND THEIR METABOLITES

NºPublicación:  WO2026047133A2 05/03/2026
Solicitante: 
THE FRANCIS CRICK INSTITUTE LTD [GB]
WO_2026047133_A2

Resumen de: WO2026047133A2

The invention relates to methods of tracking the movement of an amino acid of interest or a metabolite thereof in a eukaryotic multicellular structure, methods of diagnosis and screening related thereto, and nucleic acids encoding amino-acid stereo- isomerase for use therein.

Aptamere, aptamerbasierte Sensoren und Verfahren für den Nachweis von Neurofilament Light

NºPublicación:  DE102024124992A1 05/03/2026
Solicitante: 
FORSCHUNGSZENTRUM JUELICH GMBH [DE]
DE_102024124992_PA

Resumen de: DE102024124992A1

Die vorliegende Erfindung betrifft Aptamere, die an Neurofilament Light binden, Biosensoren, Verwendungen der Aptamere, Verfahren zum Nachweis von Neurofilament Light.

COMPOSITIONS AND METHODS FOR TREATING AUTISM SPECTRUM DISORDER USING GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR (GM-CSF)

NºPublicación:  WO2026050116A1 05/03/2026
Solicitante: 
UNIV COLORADO REGENTS [US]
WO_2026050116_PA

Resumen de: WO2026050116A1

Embodiments of the instant disclosure relate to intervention and/or treatment of autism spectrum disorder (ASD). Certain embodiments relate to treating a subject having ASD with one or more proinflammatory cytokines. In some embodiments, the one or more proinflammatory cytokines include, but are not limited to, granulocyte-macrophage colony-stimulating factor (GM-CSF) or derivative thereof, or fusion polypeptide thereof, or recombinant thereof. Other embodiments include a mouse model for assessing efficacy of treatment of ASD in humans and other mammals.

Methods and Reagents for Toxoplasma Infection Diagnosis

NºPublicación:  US20260063633A1 05/03/2026
Solicitante: 
MCLEOD RIMA [US]
LIMONNE DENIS [FR]
PEYRON FRANCOIS [FR]
EL BISSATI KAMAL [US]
LYKINS JOE [US]
WALLON MARTINE [FR]
GOMEZ MARIN JORGE [CO]
ZHOU YING [US]
US_20260063633_PA

Resumen de: US20260063633A1

0000 Point-of-care (POC) testing for T. gondii infection can potentially address cost concerns and lead to better clinical outcomes through improved access to screening. This disclosure provides methods and compositions for whole blood POC testing to identify T. gondii infection with high sensitivity and specificity, obviating the need for venipuncture and sample processing infrastructure, making it an efficient, low-cost POC test.

DPP3 BINDERS FOR THE TREATMENT OF ENDOTHELIAL DYSFUNCTION

NºPublicación:  WO2026046968A1 05/03/2026
Solicitante: 
4TEEN4 PHARMACEUTICALS GMBH [DE]
WO_2026046968_A1

Resumen de: WO2026046968A1

Subject of the invention are DPP3 binders for use in therapy or prevention of endothelial dysfunction in a patient wherein the level of Pro-Adrenomedullin or a fragment thereof in a sample of bodily fluid obtained from said patient is above a threshold, as well as methods of therapy guidance or therapy stratification or therapy monitoring of a treatment of a patient with a DPP3 binder, the methods comprising: providing a sample of bodily fluid of said patient; determining the level of Pro-Adrenomedullin or a fragment thereof in said sample; and comparing said level of Pro-Adrenomedullin or a fragment thereof to a threshold; wherein the level of Pro-Adrenomedullin or a fragment thereof in said sample being above said threshold is indicative that said patient requires treatment with a DPP3 binder, or wherein if said level of Pro-Adrenomedullin or a fragment thereof in said sample is above said threshold, said patient is treated with a DPP3 binder.

MANIPULATING UHRF1 EXPRESSION IN HEPATOCYTES

NºPublicación:  WO2026047621A1 05/03/2026
Solicitante: 
NEW YORK UNIV IN ABU DHABI CORPORATION [AE]
WO_2026047621_A1

Resumen de: WO2026047621A1

Provided is a method that involves inhibiting expression of UHRF1 in liver cells of an individual. Inhibiting the expression of UHRF1 promotes an inhibition of reduction of bone density or an increase in bone density, or inhibition of weight gain or a reduction in adipose mass, or inhibition of development of gray hair or an increase in activity level, or a decrease in biological age or enhanced liver regeneration, or increased survival following partial hepatectomy, or a combination of such effects.

COMPOSITIONS AND METHODS FOR DETECTION OF GENE EXPRESSION

NºPublicación:  WO2026050159A1 05/03/2026
Solicitante: 
FYR DIAGNOSTICS INC [US]
WO_2026050159_PA

Resumen de: WO2026050159A1

Provided herein are methods for enriching tumor derived EVs or brain-derived EVs from a biological sample, e.g. a biofluid, using a lectin or glycan-binding fragment thereof and an isolation component (e.g., a solid media). The present disclosure also provides compositions and kits for isolating brain-derived EVs or tumor derived EVs, and compositions comprising an isolated population of brain-derived EVs or tumor derived EVs.

METHODS FOR USING FV-HSP72 FOR TREATING INJURY

Nº publicación: WO2026050297A2 05/03/2026

Solicitante:

RUBICON BIOTECHNOLOGY LLC [US]

WO_2026050297_A2

Resumen de: WO2026050297A2

The present disclosure relates to compositions comprising modified heat shock proteins conjugated to a humanized 3E10 antibody or antigen-binding fragment thereof as well as methods of using the same to treat blast injury to the eye, brain, and cochlea.

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