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ORAL PRODUCTS, THREE-DIMENSIONAL PRINTERS USED FOR FORMING ORAL PRODUCTS, AND THREE-DIMENSIONAL PRINTING METHODS FOR FORMING ORAL PRODUCTS

Resumen de: WO2025111344A1

A method of making an oral product includes printing a first product portion of an oral product using of a three-dimensional printer. The first product portion has a first composition. The method further includes printing a second product portion of the oral product using the three-dimensional printer, the second product portion having a second composition different from the first composition, the first product portion and the second product portion defining distinct, non-mixed regions of the oral product.

A SHRINKING AND SETTING BIOINK

Resumen de: WO2025099720A1

Provided is a hybrid hydrogel composition and methods for its preparation and use in 3D printing biomaterials for tissue engineering applications. The hybrid hydrogel composition comprises discrete hydrogel particles of a first crosslinked polymeric network, interpenetrated- through and threaded by a second crosslinked polymeric network, dispersed in a medium. The first polymer is a thermo-responsive polymer, while the second is a protein-based thermo¬ denaturing polymer. The process for preparing this composition involves mixing swelled hydrogel nanoparticles of the first polymer with a non-crosslinked hydrogel of the second polymer in the presence of a crosslinking agent for the first polymer. The 3D printing method utilizes this composition below the LCST of the thermo-responsive polymer, followed by temperature increase wherein the second polymer cures and fixes the printed ink. This approach enables the creation of high-resolution structures, including artificial tissues with capillary blood vessels, featuring dimensions less than 50 μm.

RESIN COMPOSITION FOR STEREOLITHOGRAPHY

Resumen de: EP4796568A1

0001 The present invention provides a resin composition for stereolithography that exhibits excellent strength, toughness, water resistance, and stress retention in the shaped article while reducing the amount of leachables. The present invention relates to a resin composition for stereolithography comprising a monofunctional methacrylic polymerizable compound having a plurality of independent aromatic rings (A), a polyfunctional (meth)acrylic polymerizable compound (B), and a photopolymerization initiator (C).

POLYOXAZOLIDONE DERIVATIVES AND THEIR USE IN MEDICAL DEVICES

Resumen de: EP4541837A1

The invention provides poly(hydroxy oxazolidone) compounds (PHOx) corresponding to following formula (I) or formula (II):whereinR_1', R_2', independently of one another each denote a C1 to C20 alkyl group, preferably a C1 to C10 alkyl group, more preferably a C1 to C3 alkyl group, most preferably a methyl group, and- R₃, R₄ independently of one another each denote hydrogen or a C1 to C20 alkyl group, preferably a C1 to C10 alkyl group, more preferably a C1 to C3 alkyl group, most preferably a methyl group, and- R₅, R_5', R₆, R_6', independently of one another each denote hydrogen or a C1 to C20 alkyl group, preferably a C1 to C10 alkyl group, more preferably a C1 to C3 alkyl group, most preferably a methyl group, or an aryl group, preferably a phenyl group, and- A is an organic linking group selected from a linear, branched, saturated, unsaturated, cyclic and/or non-cyclic aliphatic, aromatic or araliphatic hydrocarbon group, preferably having 1 to 20, more preferably 1 to 12, most preferably 1 to 8 carbon atoms and optionally further containing one or more functional groups selected from ether, ester, amide, amine, carboxyl, sulfur, halogen and/or urethane, and- Optionally A, R₃ and R₄ in formula (I) are linked to each other to form a cyclic structure, and- Optionally R₅ and R_5', and/or R₆ and R_6' in formula (II) are respective

SYSTEM MAINTAINANCE TECHNIQUES

Resumen de: WO2025088603A1

A service providing apparatus is disclosed comprising a service platform configured for movement along a path having one or more object treatment zones, each object treatment zone comprising equipment configured to apply one or more treatment processes to surface areas of objects carried by one or more objects' platforms along said path. At least one service providing unit is mounted on the service support platform for applying one or more service procedures to the equipment of at least one of the one or more object treatment zones while the support platform is located within the at least one treatment zone, to thereby apply the one or more service procedures while the one or more objects' platforms are located along the path.

NEBULISER

Resumen de: EP4796149A1

0001 The present invention provides a nebuliser (100) comprising one or more inputs (110), and a plurality of droplet ejectors (126) in fluid communication with the one or more inputs (110). Each droplet ejector comprises a nozzle portion and a piezoelectric actuator. The one or more inputs are for receiving one or more liquids. Each nozzle portion defines a nozzle outlet in fluid communication with the one or more inputs. Each piezoelectric actuator is operable to cause ejection of a liquid received by one of the one or more inputs through the respective nozzle outlet as one or more droplets. The nebuliser is configured to generate an aerosol comprising the respective one or more droplets ejected by one or more of the plurality of droplet ejectors. At least 50%, by mass, of the droplets of the aerosol have a diameter of at least 5 x 10<-6> m.

ELECTRONIC DEVICE, AND METHOD FOR OUTPUTTING NOTIFICATION SIGNAL FOR MEDICATION INTAKE BY USING SAME

Resumen de: EP4796098A1

According to an embodiment, the electronic device may comprise a display, a processor, and a memory for storing a medication intake schedule, and instructions. The instructions, when executed by the processor, may cause the electronic device to: display a clock screen including an icon for at least one medication on the basis of the medication intake schedule; identify a notification time for the intake of the at least one medication on the basis of the medication intake schedule; identify an adjustment condition for a medication intake-related notification signal on the basis of the identified notification time; adjust an output time point of the notification signal for the intake of the at least one medication, on the basis of the identified adjustment condition of the medication intake-related notification signal; and display a visual effect corresponding to the icon included in the clock screen, on the basis of the adjusted output time point. Various other embodiments may be possible.

DEVICES AND RELATED METHODS FOR VENTILATION

Resumen de: EP4796155A2

Provided herein are devices and methods that relate to ventilation and respiration. In one embodiment, a ventilator device comprising a fluidic amplifier with one or more coaxially aligned components, where there are no internal moving components. In another embodiment, a device and related methods for treating a patient who needs ventilation such as after infection by the coronavirus Covid-19.

MEDICATION DELIVERY SYSTEM

Resumen de: EP4797275A1

A medication delivery system, including a wearable device configured to automatically deliver medication based on food order information received from a user computing device. The medication is delivered via a pump, and the medication may be insulin. The food order information includes timing information and/or information about the food ordered necessary to change a medication delivery. A controller determines a medication adjustment based on an estimated physiological response to the food order information. A delivery pump automatically delivers the medication, e.g., an insulin bolus, prior to or in anticipation of food consumption.

A METHOD FOR VOLUMETRIC PRINTING A DENTAL COMPONENT BY PHOTOPOLYMERIZATION OF A PHOTOCURABLE RESIN

Resumen de: EP4796291A1

0001 A method for volumetric printing a dental component by photopolymerization of a photocurable resin.

SYSTEMS, DEVICES, COMPONENTS AND METHODS FOR DETECTING THE LOCATIONS OF SOURCES OF CARDIAC RHYTHM DISORDERS IN A PATIENT'S HEART

Resumen de: EP4797280A2

0001 Disclosed are various examples and embodiments of systems, devices, components and methods configured to detect a location of a source of at least one cardiac rhythm disorder in a patient's heart. In some embodiments, electrogram signals are acquired from a patient's body surface, and subsequently normalized, adjusted and/or filtered, followed by generating a two-dimensional spatial map, grid or representation of the electrode positions, processing the amplitude-adjusted and filtered electrogram signals to generate a plurality of three-dimensional electrogram surfaces corresponding at least partially to the 2D map, one surface being generated for each or selected discrete times, and processing the plurality of three-dimensional electrogram surfaces through time to generate a velocity vector map corresponding at least partially to the 2D map. The resulting velocity vector map maybe employed to classify a patient as one of an A-type patient, a B-type patient, and a C-type patient, and to guide therapy subsequently delivered to the patient. Trained atrial discriminative machine learning models that facilitate the foregoing systems and methods, and that provide predictions or results concerning a patient's condition, are also disclosed.

Emergency cardiac and electrocardiogram electrode placement system with artificial intelligence

Resumen de: US12714353B1

0000 An emergency cardiac and electrocardiogram (ECG) electrode placement device with artificial intelligence is disclosed herein. The emergency cardiac and electrocardiogram (ECG) electrode placement device incorporates electrical conducting materials and elastic material into a pad that is applied to a chest wall of a patient, which places multiple electrodes in the appropriate anatomic locations on the patient to quickly obtain an ECG in a pre-hospital setting. The AI program continuously runs EKGs to continuously monitor a patient.

一种微透镜、其制备方法及应用

Resumen de: WO2025120669A1

The present disclosure provides a three-dimensional hydrogel prepared using a bioink composition comprising methacrylated hyaluronic acid, methacrylated gelatin, a photoinitiator and a photoabsorber; and a method for preparing the three- dimensional hydrogel or lenticule. The present disclosure further provides a method of treating corneal tissue repair in a subject in need thereof using the three- dimensional hydrogel or lenticule.

Three-dimensional reconstruction of interiors of closed containers

Resumen de: US12715123B1

A system for three-dimensional (3D) reconstruction of interiors of a closed container (e.g., a refrigerator) is provided. A track is mounted inside the refrigerator. A robot is configured to navigate along the track. The robot may include control modules and puller and pusher modules that are magnetically coupled to the control modules. The puller module may pull the control modules along the track, whereas the pusher module may push the control modules along the track. Each control module may include an image sensor that captures images of the physical space inside the refrigerator. The track is mounted such that by navigating along the track, the robot (e.g., the image sensors) can capture an entire scene of a physical space inside the refrigerator from different angles and locations within the refrigerator. Based on the captured images, a 3D representation of the physical space is generated.

一种仿生3D打印水凝胶支架及其制备方法与应用

Resumen de: CN122624750A

本发明公开了一种仿生3D打印水凝胶支架及其制备方法与应用，属于医疗器械技术领域。该仿生3D打印水凝胶支架包括3D打印水凝胶支架和在3D打印水凝胶支架表面的仿贻贝催化涂层；3D打印水凝胶支架的生物墨水包括甲基丙烯酰化明胶、钙离子预交联海藻酸钠、负载STING激动剂的树突状细胞来源外泌体以及甲基丙烯酰化修饰的成骨生长肽；仿贻贝催化涂层由聚多巴胺层和负载在聚多巴胺层表面的多巴胺‑锰金属多酚网络纳米酶共同构成。通过各组件协同作用，有效解决了现有支架缺乏时序性治疗机制的技术问题，实现了骨转移肿瘤治疗中肿瘤清除与骨缺损修复的双重效果。

一种3D打印工艺制作的颅骨矫形固定器

Resumen de: CN224671675U

本实用新型提出一种3D打印工艺制作的颅骨矫形固定器，包括前片壳体和后片壳体，所述前片壳体和后片壳体的顶部均设有端部开口的凹槽结构，当所述前片壳体和后片壳体通过连接结构连接后，所述前片壳体和后片壳体的顶部的凹槽结构的开口处连通，用于放置皮筋，以此加强所述前片壳体和后片壳体连接的稳定性，同时防止在连接结构失效后，还能够通过凹槽结构与皮筋的配合方式使得所述前片壳体和后片壳体不至于完全脱离患者头颅，同时，前片壳体和后片壳体的顶部密封可以防止颅骨长出去并且能够加固整个颅骨矫形固定器的结构强度，从而可以使得颅骨矫形固定器的壁厚做薄，减轻重量。

一种用于骨组织修复的增韧型PLGA/P34HB复合材料及其制备方法

Resumen de: CN122624747A

本发明公开一种用于骨组织修复的增韧型PLGA/P34HB复合材料及其制备方法，属于生物可降解功能材料的技术领域。该复合材料由聚(乳酸‑乙醇酸共聚物)(PLGA)、聚(3‑羟基丁酸‑4‑羟基丁酸共聚物)(P34HB)和γ‑缩水甘油醚氧硅丙基倍半氧烷(POSS)经无溶剂熔融共混制得；POSS与PLGA和P34HB端基原位反应形成共价界面，实现P34HB纳米级均匀分散；复合材料断裂伸长率提升至100%以上，保持良好刚度和强度，无溶剂残留，生物相容性优良，适用于熔融挤出3D打印制备骨修复支架，可用于口腔相关骨缺损修复。

一种3D打印抗炎生物可降解气道支架的制备方法

Resumen de: CN122624763A

本发明公开了一种3D打印抗炎生物可降解气道支架的制备方法，采用可降解生物材料3D打印技术制备定制化的气道支架，再对其进行表面功能化，表面接枝抗炎药物布洛芬，进一步制备具有抗炎功能的可生物降解气道支架。此支架提供长期的力学支撑的同时降低植入部位的炎症反应，从而为快速制备用于临床应用的个性化可降解气道支架提供新的解决方案。制备方法包括：利用3D打印技术制备定制化气道支架；利用表面改性手段，获得支架表面交联的胺化支架；再进一步利用布洛芬与表面氨基的酰胺化反应获得具有抗炎功能的气道支架。本发明工艺可重复性好，个性化定制性能优良，可作为治疗中央气道阻塞的有效手段。

一种具有骨诱导活性的聚肽仿生纳米纤维支架及其制备方法与应用

Resumen de: CN122624735A

本发明属于医用生物材料技术领域，尤其是涉及一种具有骨诱导活性的聚肽仿生纳米纤维支架及其制备方法与应用。本发明采用合成聚肽，通过表面引发聚合在铋取代羟基磷灰石上接枝PBLG，解决颗粒团聚及界面问题；引入含双键共聚物PBLG‑co‑(LG‑g‑APEG)，经3D打印交联形成共价网络增强力学性能；结合相分离获得仿ECM纳米纤维结构。本发明所得支架兼具宏观大孔和微观仿生纤维网络，有机无机杂化组分提供矿化界面，铋离子释放促成骨，实现骨缺损修复。

基于热-力耦合优化的PEKK颅骨补片增材制造支撑方法

Resumen de: CN122626477A

本发明公开了一种基于热‑力耦合优化的PEKK颅骨补片增材制造支撑方法，属于高性能聚合物增材制造技术领域。该方法通过对PEKK复杂曲面薄壳颅骨补片打印过程中的热场、应力场及曲率分布进行分析，构建曲率驱动的梯度支撑体系，并提出主承载脊柱‑热缓冲枝杈双级支撑网络，实现打印稳定性、热变形控制及材料利用率之间的协同优化。本发明能够显著降低PEKK颅骨补片FFF打印过程中的热翘曲与支撑耗材量，具有良好的工程应用价值。

一种3D打印气管支架及其制备方法

Resumen de: CN122624218A

本发明公开了一种3D打印气管支架及其制备方法，该支架包括多个经向单元和多个纬向单元：经向单元由第一经向连接段、第二经向连接段及连接两者的经向内凸弹性段构成；纬向单元由第一纬向连接段、第二纬向连接段及连接两者的纬向内凸弹性段构成；多个经向单元沿不同经度方向依次串联形成多条经向链，多条经向链周向间隔布置；多个纬向单元分别连接于相邻经向链之间，与经向链共同形成柱状网格支架。本发明通过经向内凸弹性段与纬向内凸弹性段的几何‑力学耦合特性，实现了支架支撑与顺应功能的解耦，从根本上消除了支架移位的力学根源。

一种葡萄糖/氧化应激双响应双层水凝胶敷料、制备方法及其应用

Resumen de: CN122624726A

本发明涉及生物医用材料技术领域，特别是涉及一种葡萄糖/氧化应激双响应双层水凝胶敷料、制备方法及其应用，所述的双层水凝胶敷料在糖尿病伤口高糖、高活性氧的病理微环境中，交联网络响应性解体，释放负载的功能模块；在正常组织或愈合后期微环境趋于正常时，材料保持稳定；具有早期感染控制、中期能量补给与免疫调节、晚期基质重塑与疤痕抑制的全周期治疗需求，在促进糖尿病伤口高质量、无疤痕愈合方面的卓越效果和深远的临床转化潜力。

一种含芳基吡啶盐的光固化3D打印树脂及制备方法和应用

Resumen de: CN122627973A

本发明涉及新材料技术领域，具体涉及一种含芳基吡啶盐的光固化3D打印树脂及制备方法和应用。具体技术方案为：本发明将可光固化吡啶盐活性单体、光引发剂、活性稀释剂、丙烯酸酯类低聚物、添加剂均匀混合得到3D打印树脂，并将其用于义齿基托的打印。本发明方法反应充分，工艺相对简单，易于实现，可根据需求设计不同结构的含芳基吡啶盐光固化树脂，且少量添加即可表现出极佳的抗菌性。

精神健康モニタリングのためのデータ処理方法及びその装置

Resumen de: WO2025221073A1

Disclosed are a data processing method and an apparatus thereof, which are capable of monitoring the mental health of a user by extracting behavior characteristic data about the user on the basis of data collected from a user equipment. The data processing method for mental health monitoring may comprise the steps of: receiving passive data from a user equipment of the user; extracting basic patterns of user activities from the passive data; and using the basic patterns so as to estimate behavior characteristic data about the user from the passive data.

バイオ複合材料組成物を作製および使用する方法

Nº publicación: JP2026528453A 21/08/2026

Solicitante:

ポリ－メッドインコーポレイテッド

Resumen de: WO2025035104A2

Disclosed herein are methods of making and using biocomposite compositions comprising at least a polymeric component and a fiber component.