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140
resultados
Última actualización
13/08/2025 [07:25:00]
Resumen de: CN120458785A
本发明涉及医疗器械技术领域，具体地说是一种基于仿生学原理的3D打印全踝关节假体。包括仿生脚、仿生小腿和仿生大腿，所述仿生小腿活动安装在仿生脚的外侧表面，所述仿生小腿和仿生大腿的外侧表面设置有散热机构，所述仿生大腿通过散热机构与仿生小腿构成活动连接，所述仿生大腿的内腔中设置有自适应贴合机构。本申请可以通过双面齿框啮合连接的带轴齿轮转动，带动与带轴齿轮啮合连接的半面卡尺向内滑动，通过拉杆拉动弧夹板向内进行夹持，压杆会压动第二气囊通过第二伸缩软管向弧气囊的内部进行充气，能够贴合不同大小和形状的肢体，弹力尼龙套保证了贴合时的舒适性和透气性。
Resumen de: CN120461813A
本发明公开了一种挤出和喷墨复合的3D打印方法。本发明通过挤出‑喷墨复合3D打印技术，以单液滴作为基本沉积单元，逐层堆积融合形成二维/三维高精度复杂结构。本发明实现了多种其他方法难以实现的高精度复杂结构打印，打印的二维复杂结构最小特征尺寸约50μm，三维复杂结构最小特征尺寸约80μm，并通过载细胞打印实现了体外跨尺度分级二维/三维血管网络的构建；且本发明所提供的方法可以实现高精度复杂三维结构的单步成型，避免了工艺切换带来的重复定位误差和二次加工，为解决复杂异质体外组织模型和复杂精细三维结构的制造难题提供了一种便捷有效的制造技术思路。
Resumen de: CN120458756A
本发明公开了一种唇颊侧固位骨膜下种植体支架及制作方法，种植体支架包括唇颊侧连接板，唇颊侧连接板上一侧设有螺钉孔，螺钉孔内设有固定于唇颊侧的螺钉，唇颊侧连接板上另一侧为弯钩结构，弯钩结构的凸起位置设有多个种植基台；唇颊侧连接板通过扫描数据重建患者完整颌骨结构，提取唇颊侧骨面轮廓，在三维模型中设计唇颊侧连接板的轮廓线后得到基础支架模型，然后通过三维有限元分析，对种植基台的布局结合应力分布结果以及唇颊侧的螺钉孔位进行优化，然后采用拓扑优化方法，并通过3D打印制造得到种植体支架。本发明在保证刚度和耐用性的同时，整体结构更加轻便，使用的螺钉数量更少，显著提高支架的使用寿命，减少压力性损伤的风险。
Resumen de: CN120458813A
本发明提供了一种双层夜磨牙口垫及其制备方法，属于医疗器械领域。本发明提供了一种双层夜磨牙口垫，由中空的GC软衬层和中空的PEEK硬质层组成，所述GC软衬层的外表面与PEEK硬质层的内表面相接触。本发明双层夜磨牙口垫的内层采用柔性生物相容材料—GC软衬层贴合牙列及软组织，极大减轻压迫感和异物感，适宜长时间佩戴，显著提升患者依从性；外层选用高强度、耐磨的PEEK，具备优异的抗咬合磨损能力和结构稳定性，特别适用于中重度夜磨牙患者的长期使用。
Resumen de: CN120458755A
本发明公开了一种腭侧固位骨膜下种植体支架及制作方法，种植体支架包括腭侧连接板，腭侧连接板上一侧设有螺钉孔，螺钉孔内设有固定于腭侧的螺钉，腭侧连接板上另一侧设有多个种植基台；唇颊侧连接板通过扫描数据重建患者完整颌骨结构，提取唇颊侧骨面轮廓，在三维模型中设计唇颊侧连接板的轮廓线后得到基础支架模型，然后通过三维有限元分析，对种植基台的布局结合应力分布结果以及唇颊侧的螺钉孔位进行优化，然后采用拓扑优化方法，并通过3D打印制造得到种植体支架。本发明兼具良好的力学稳定性与生物适应性，腭侧进路微创隐蔽，尤为适用于美学区及复杂骨缺损病例的修复需求。
Resumen de: CN120459383A
本发明公开了一种具有电磁响应骨修复多孔组织工程支架及其制备方法和应用，属于医用材料领域。本发明通过将超顺磁性纳米颗粒均匀嵌入到高分子仿生多孔支架，结合3D打印技术，构建兼具宏观力学强度与微观生物活性的分级多孔支架。利用多孔结构模拟骨细胞外基质，优化骨整合效率。同时结合支架的电磁响应特性，通过外加电磁场动态调控，诱导间充质干细胞的成骨分化并加速血管生成，通过跨学科技术融合，为临床难治性骨缺损提供一种兼具力学适配性、生物活性及智能响应性的新一代修复支架，从而实现“材料‑细胞‑微环境”三重协同修复机制。
Resumen de: CN120436978A
本发明涉及3D打印技术技术领域，具体为一种基于3D打印技术的口腔靶向复合凝胶制备方法，包括低温3D打印设备，低温3D打印设备包括双通道低温挤出喷头、五轴联动运动平台和惰性环境舱；双通道低温挤出喷头包括通道一和通道二，通道一包括益生菌微囊和温敏凝胶，温度为4‑10℃，黏度为3×10³mPa·s，通道二包括白桦多肽/茶多酚光交联预聚体，含0.5%LAP光引发剂；五轴联动运动平台：打印精度±10μm，支持舌背曲面贴合，曲率半径≥2mm；惰性环境舱：氧浓度≤0.5%，温度4‑10℃，湿度30‑40%；有益效果：高活性保留与稳定性：通过惰性环境舱（氧浓度≤0.5%）与低温打印（4‑10℃），益生菌存活率提升至打印后98%，6个月储存后仍≥85%；白桦多肽降解率≤3%，显著优于传统工艺。
Resumen de: CN120436817A
本申请的实施方式提供一种托槽定位导板及其设计方法和制备方法，其中，托槽定位导板用于将托槽安装在牙齿表面，具体包括第一定位导板，所述第一定位导板具有沿水平方向设置的第一定位部和与第一定位部唇颊/舌腭侧端连接并沿龈颌方向设置的第二定位部，第二定位部包括第一定位滑槽，所述第一定位滑槽具有在近远中方向的第一开口，托槽可通过第一开口进入第一定位滑槽；装配时，托槽颈部沿所述第一定位滑槽滑动并卡持在第一预定位置处，其中，在所述第一预定位置处托槽底板朝向牙齿表面，所述托槽定位导板佩戴在所述对应牙齿上时，所述第一预定位置处满足所述托槽底板与对应牙齿表面具有填充粘接剂的预留间隙。
Resumen de: CN120436725A
本发明公开了一种牙周辅助加速成骨正畸治疗的手术导板及其制作方法，包括：根据全口牙列牙根三维数据在填倒凹后的牙列数据上设计覆盖所有目标牙及其相邻牙齿的牙冠表面的固位结构模型；在颌骨三维数据的颊侧骨面上分别设计与固位结构模型连接的第一定位结构模型和第二定位结构模型；根据全口牙列牙根三维数据在第一定位结构模型上设计线状开口区域，得到骨皮质切开线定位结构模型，并得到骨皮质切开限位导板数据和骨增量限位导板数据；基于骨皮质切开限位导板数据和骨增量限位导板数据分别进行打印，得到骨皮质切开限位导板和骨增量限位导板。本发明能够提高手术区域的定位准确度，降低手术难度。
Resumen de: CN120436842A
本发明关于一种整形外科可植入可指导软骨塑形的3D打印耳支架，涉及3D打印技术领域。包括支架本体，支架本体上设有缺口，支架本体边缘设有边缘突出部，支架本体的一侧设有反求过来的耳廓部；支架本体的下部向上回折形成钩状部。本发明能够实现高精度的耳部重建，为耳部缺损或畸形的患者提供一种创新、安全且效果优异的修复手段。
Resumen de: CN120436861A
本发明公开了一种桡骨远端骨折的3D打印个性化夹板及其制作方法，包括：背侧板、掌侧板、尺侧板和桡侧板，背侧板、掌侧板、尺侧板和桡侧板均为曲面形夹板，曲面的方向与桡骨形状契合；每个夹板的宽度从手腕向手肘方向逐渐增大；每个夹板的两侧均设置边缘减薄结构；每个夹板的上表面相应位置上设有多对加强筋，在每对加强筋上设有绑带限位卡扣，每对加强筋中的两加强筋之间且位于绑带限位卡扣的正下方处设有绑带下陷平台；背侧板对应位置设置有防尺侧压疮凹陷、防背侧碰撞凹陷和第一防桡侧压疮凹陷；掌侧板对应位置设置有防掌侧肌肉压迫切面；桡侧板对应位置设置有第二防桡侧压疮凹陷。本发明针对患者的个体化差异，制作出满足要求的个性化夹板。
Resumen de: CN120437373A
本发明涉及一种仿生软骨膜‑软骨及其一体化的构建方法和应用，涉及复合生物材料领域。包括如下步骤：(1)将功能性分子和聚己内酯在第一溶剂中共混，得到第一混合溶液；将所述第一混合溶液通过静电纺丝技术，构建功能性的取向纳米纤维膜；(2)采用3D打印技术，在所述功能性的取向纳米纤维膜上进行工程软骨的仿生3D打印，得到第一部分待交联的仿生软骨膜‑软骨；(3)重复步骤(2)的步骤，得到第二部分待交联的仿生软骨膜‑软骨；将两部分依次进行对合、交联反应，得到仿生软骨膜‑软骨。本发明实现了软骨膜‑软骨的仿生一体化构建，并增加其力学强度。
Resumen de: CN119789957A
The invention relates to a novel silicone foam obtained from a foamable, crosslinkable silicone composition, the invention relates to a composition comprising an organopolysiloxane having at least two silicon-bonded alkenyl groups per molecule, an organosilicon-containing compound having at least two and preferably at least three silicon-bonded hydrogen atoms per molecule, a hydrosilylation catalyst, at least one porogen as water, hydrogel or aqueous silicone emulsion, and at least one surfactant, at least one chemical blowing agent; and a linear polydimethylsiloxane.
Resumen de: CN120051272A
The present invention relates to a process for preparing a solid pharmaceutical administration form comprising an amorphous solid dispersion using a 3D printing process. The process is a printing process which allows the production of solid administration forms of a solid drug comprising an amorphous solid dispersion in a simple and flexible manner and makes it possible to obtain rapidly disintegrating dosage forms with high drug loading.
Resumen de: WO2025163396A2
A system may include a donor supply sub-system configured to supply donor material to a donor substrate. The system may include a material transfer sub-system comprising a laser configured to illuminate the donor substrate via a transfer beam. The system may include an instrument head of a medical instrument configured to house the donor substrate, wherein upon an illumination of the donor substrate, the donor material is transferred to receiver material in vivo.
Resumen de: WO2025163465A1
The present invention provides a method and system for fabricating complex human tissues by integrating bio-electrospraying, cell electrospinning merged with 3D multi material microfluidic bioprinting, and future additions of magnetic and acoustic levitation technologies. The fabricated tissues serve as an alternative to animal testing in drug discovery processes, aiding in the prediction of human physiological responses to various drug compounds.
Resumen de: WO2025163003A1
The invention relates to a method for adapting a composite medical shoe to a human foot (1). A pressure protection element (2) serves to relieve pressure from the human foot or parts thereof.
Resumen de: US2025252697A1
A method for fabricating a custom headwear for a subject is described. The method comprises generating a three-dimensional head data file for the subject and determining contour lines on the head; automatically generating a headwear data file. The method yet further comprises utilizing the headwear data file to generate a shape for a desired headwear, the shape having an interior configured to restrain growth of the head in first predetermined areas. Still further, the method comprises generating contour lines for the custom headwear.
Resumen de: US2025250522A1
A device for modelling physiological and pathophysiological states of the brain is provided. The device comprises a hydrogel with micropattern channels having a length, width and depth. The micropattern channels comprise cells selected from the group consisting of neurons, astrocytes, microglia, oligodendrocytes, neuronal organoids, cancer cells, cancer spheroids, brain tumoral cells and combinations thereof.
Resumen de: US2025248902A1
The present invention relates to a curable composition for dental purposes. The invention is characterized in that the composition comprises core-shell impact modifiers and 0.1 to 10 wt. % of a binder based on long-chain mono-functional (meth)acrylic acid esters, wherein the ester group has a carbon chain with at least 3 carbon atoms. The invention also relates to the use of the composition as a dental material or a dental auxiliary material, to a dental product made of the composition, and to a method for producing the dental product.
Resumen de: US2025248828A1
The Invention refers to a method for manufacturing a new prosthesis for a lower limb, the method comprising the following steps:a) Providing 3D-data of a prior inner surface of a prior socket and of ist position and its orientation relative to a component adapter, —b) Creating a 3D model of a prosthetic socket with an attachment area for a socket adapter, wherein the prosthetic socket has an inner surface based on the scanned prior inner surface and an outer surface, —c) Determining information about an orientation transmitter, —d) Manufacturing of the prosthetic socket based on the 3D model and providing the orientation transmitter based on the information, —e) Directly or indirectly connecting the manufactured socket to a component adapter by means of the orientation transmitter so that the position and orientation of the inner surface of the prosthetic socket relative to the position and orientation of the component adapter corresponds to the position and orientation of the prior inner surface of the prior socket to the component adapter.
Resumen de: AU2024212880A1
An apparatus comprises a soft robotic arm and a three-dimensional (3D) bioprinter. The soft robotic arm has actuators for controlling movements of a distal end of the soft robotic arm. The 3D bioprinter is attached to the distal end of the soft robotic arm, and has a print nozzle and soft microtubule artificial muscles (SMAMs) for controlling movements of the print nozzle.
Resumen de: WO2025164130A1
Provided are: a curable composition for three-dimensional stereolithography, which contains 100 parts by mass of a polymerizable monomer component (A), 40-400 parts by mass of an inorganic filler (B), 0.01-5 parts by mass of a photoinitiator (C), and 0.01-2.5 parts by mass of an activation light absorber (D), and in which 10-90 mass% of the inorganic filler (B) is contained as an organic-inorganic composite filler (E), the value of light scattering index Sc serving as an index of the proportion of light scattered laterally when being irradiated with activation light is 10% or less, and the rate of transmission for activation light in a state prior to being optically cured is 1-50%; and a method for producing the curable composition for three-dimensional stereolithography. The present invention also provides a method for producing a three-dimensional stereolithographic product and a method for producing a dental restoration article, in both of which said curable composition for three-dimensional stereolithography is used.
Resumen de: WO2025165052A1
The present invention relates to a method for activating natural killer cells, comprising a step of providing electrical stimulation to natural killer cells. Specifically, electrical stimulation under predetermined conditions is applied to natural killer cells by applying an electrical stimulation system established through a 3D-printed electrical stimulation device and a function generator. Here, cancer cell-killing ability and calcium ion-mediated mechanisms are analyzed among induced intracellular effects. In addition, with respect to the natural killer cells produced according to the present invention, a method capable of enhancing the efficacy of a cell therapeutic agent without introducing genetic modification is presented, and the cells can be used to study the correlation between the cancer cell-killing ability and the intracellular calcium ion levels of electrically stimulated natural killer cells.
Nº publicación: WO2025166097A1 07/08/2025
Solicitante:
ZIMA INT INC D/B/A DANDY [US]
ZIMA INTERNATIONAL, INC. D/B/A DANDY
Resumen de: WO2025166097A1
Disclosed are systems and methods of a decision intelligence (DI)-based computerized framework that automatically and/or dynamically implements a color algorithm for performing staining and glazing dental restorations. The framework operates by leveraging determined color variations through AI/ML-based analysis that generate detailed color maps, which can be translated into precise printing instructions controlling the mixture and layering of dental-grade glazing materials. A printing system can employ multiple print heads with varying base colors and opacity levels to create microscopic color gradients and translucency effects matching natural tooth enamel. The disclosed automated processing applies personalized color patterns in microscopically thin layers, ensuring consistent glaze thickness while replicating regional variations across the tooth surface. Such approach eliminates manual glazing variability while achieving superior customization compared to traditional pre-set patterns, resulting in dental restorations that integrate seamlessly with existing teeth.
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