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一种距下关节固定装置

Resumen de: CN223416347U

本实用新型提供了一种距下关节固定装置，属于医疗器械技术领域。该距下关节固定装置包括足托，足托套设在穿戴者的足跟部；足托包括底板以及设置在底板两侧顶端的第一侧板与第二侧板，第一侧板与第二侧板相对向内折弯，第一侧板与第二侧板顶端分别向底板方向凹陷形成有凹槽；第一侧板与第二侧板与穿戴者的脚踝相贴合。该距下关节固定装置结构简单，适应性好，能充分开放前足活动空间，减少穿戴不适感，达到用户自我锻炼重塑肌肉韧带及行走发力问题，安全性高。

一种仿生灯笼框架复合内固定装置及制备方法

Resumen de: CN120753772A

本发明公开了一种仿生灯笼框架复合内固定装置及制备方法，涉及骨科医疗器械技术领域，包括植入体和多棒桥接结构，多棒桥接结构由多个纵向连接棒与横向锁定钉组成，植入体由多个多层级仿生结构组成，多层级仿生结构包括两个对称设置的六边形上下层结构以及设置在两个六边形上下层结构之间的中间螺旋层结构。本发明从蜂窝与耗牛角宏微观结构中受到启发，采用耦合仿生技术制备出的多层级仿生结构具有优异的力学性能，缓冲吸振能力强，可有效匹配天然骨力学性能，可有效避免患者植入后二次损伤和“应力屏蔽”效应，通过电化学沉积方法引入的复合涂层弥补了单一植入体结构生物相容性不足、抗菌性不足、成骨分化能力弱的问题。

功能化丝素蛋白基生物墨水、仿生软骨水凝胶及其制法

Resumen de: CN120754319A

本发明属于生物材料与组织工程技术领域，涉及一种功能化丝素蛋白基生物墨水、仿生软骨水凝胶及其制法。该墨水含有引发剂、SFMA、GelMA、PEGDA和OBC，各组分的配比严格控制；将该墨水与干细胞混合均匀后，引发固化交联反应，制成多重仿生软骨水凝胶。该水凝胶包括多重网络结构水凝胶以及同时分散在多重网络结构水凝胶中的OBC及干细胞，具有和真实软骨组织匹配的压缩模量以及多孔结构。本发明提供的功能化丝素蛋白基生物墨水及多重仿生软骨水凝胶，解决了现有技术中供体不足、免疫排斥、仿生维度单一、力学性能不匹配等问题，能实现高精度打印并高效促进软骨再生。

一种带有螺硫吡喃基团的聚氨酯丙烯酸酯及其合成方法和应用

Resumen de: CN120757748A

本发明提供了一种带有螺硫吡喃基团的聚氨酯丙烯酸酯及其合成方法和应用，涉及义齿基托材料技术领域。带有螺硫吡喃基团的聚氨酯丙烯酸酯中将螺硫吡喃的C‑S弱共价键引入聚氨酯丙烯酸酯主链中，利用其在外力作用下易发生均裂的特性来耗散能量，并通过自由基介导的点击反应实现链间交联，从而增强机械强度，使其适用于义齿基托、口腔修复体、生物医学植入物等领域。

一种运用3D打印技术制作可降解的乳房植入物的方法

Resumen de: CN120756090A

本申请提供了一种运用3D打印技术制作可降解的乳房植入物的方法，包括以下步骤：在3D打印喷头的加热腔内灌注打印材料；对加热腔加热至温度到达预设温度时3D打印设备开始打印工作，包括打印喷头的喷嘴挤出打印材料，并按预设程序在打印平台上方移动，保持加热腔温度稳定在预设温度；预设程序包括打印路径以预设图形的中心为起点，沿径向从内向外逐层打印，完成预设图形最后一层时打印工作结束；停止对加热腔的加热。通过加热腔稳定持续的加热，材料分子量逐渐减小，结合3D打印方法自预设图形由内向外逐层打印，使得乳房植入物的分子量自中心向外层逐层减小，解决了现有手段制作的乳房植入物的降解方向与细胞再生进程无法动态协同的问题。

AUTOMATED METHODS FOR DESIGNING AND FABRICATING AN INTRA-ORAL APPLIANCE

Resumen de: US2025312122A1

A method for designing a custom-made intra-oral appliance includes obtaining a virtual 3D reconstruction of an oral cavity, identifying an appliance region, obtaining a 3D appliance mesh from the appliance region, and processing the 3D appliance mesh for obtaining a volumetric appliance mesh. A method for obtaining a virtual 3D reconstruction of an oral cavity, the virtual 3D reconstruction being suitable for use in designing custom-made intra-oral appliances, and a method for designing an intra-oral appliance. The method for obtaining a virtual 3D reconstruction of an oral cavity includes obtaining at least one 2D image of an oral cavity, wherein the at least one image is acquired by a consumer electronics product, transforming the obtained at least one 2D image into an initial virtual 3D reconstruction of the oral cavity, and transferring information included in a further virtual 3D reconstruction to the initial virtual 3D reconstruction.

METHODS AND SYSTEMS FOR CUSTOM NIPPLE

Resumen de: WO2025213195A1

Methods and systems are described for creating a custom nipple generated from a custom mold based on a series of images of a nipple region.

Apparatus and Methods for Small Joint and Bony Defect Replacement

Resumen de: US2025312160A1

Apparatus and methods for joint and bony segment replacement may utilize additive manufacturing (e.g., 3D printing) of various anatomic constructs with PEEK/zeolite/ion (PZI) material. Heavy metal ion loading options may be utilized which may provide differing properties to different surfaces of the resultant apparatus. Moreover, using the PZI material, the apparatus being implanted in joint and bony segment replacement may favorably manipulate the biologic microenvironment in which it may be implanted. Further, through use of PZI material, current large joint replacement options also may be disrupted including, but not limited to, modifications of the joint replacement itself, and the augments and supporting joint reconstruction devices used in bone loss situations. Methods for joint and bony segment replacement may provide mixing two or more types of PZI material together through an additive manufacturing process; and introducing the mixture as part of an implantable apparatus.

IMPLANT COMPRISING NONBIOLOGIC PORTION AND BIOLOGIC PORTION

Resumen de: US2025312159A1

In one aspect, an implant for replacing subject tissue includes a nonbiologic portion and a biologic portion grown on the nonbiologic portion. The biologic portion may be grown on the nonbiologic portion before being implanted in the subject. The nonbiologic portion may comprise a porous metal substrate (e.g., scaffolding). The nonbiologic portion may be formed by 3D printing (i.e., additive manufacturing). The nonbiologic portion may be patient-specific. A robot may be used to shape the implant before implantation and/or to shape bone being replaced/resurfaced.

PATIENT-SPECIFIC HUMERAL HEAD GUIDE DEVICE AND SYSTEMS AND METHODS FOR MANUFACTURING SAME

Resumen de: US2025312048A1

A patient-specific humeral head guide device may be designed and manufactured to contour the shape of the humeral head of the patient, as determined from the medical images. For example, a system may generate computer-assisted manufacturing (CAM) instructions based on one or more medical images of the shoulder of the patient. The CAM instructions may include G-code that causes a three-dimensional (3D) printer to manufacture a patient-specific humeral head guide device. The system may generate G-code for other various portions of the patient-specific humeral head guide device. For example, the system may generate instructions for manufacturing a patient-specific humeral head guide device to include a footprint (including a body and an extended footprint) that contours the humeral head, a plurality of fixation wire channels (for drilling to receive a respective fixation wire), a reaming channel, a resection channel (for cutting), and/or other portions described herein.

COMPOSITE POSITIVE AND NEGATIVE POISSON’S RATIO TISSUE ADHESIVES

Resumen de: US2025312511A1

Some tissue adhesives include a solid having bio-absorbable fibers and at least one of nano-spheres, micro-spheres, nano-tubules, or micro-tubules. A first layer of the solid has a positive Poisson's ratio and a second layer of the solid has a negative Poisson's ratio. In some cases, the second layer has been transformed from a positive Poisson's ratio material to a negative Poisson's ratio material. In some cases, an entire face of the first layer is in contact with an entire face of the second layer. In some cases, the second layer includes one or more pores, at least a portion of the one or more pores containing a secretion from one or more barnacles. In some cases, the secretion is configured to adhere the tissue adhesive to one or more layers of tissue to at least partially close a wound.

METHOD FOR MANUFACTURING POLYMER-BASED MICRONEEDLE PATCH AND MICRONEEDLE PATCH MANUFACTURED THEREBY

Resumen de: US2025312584A1

The present invention relates to a method for manufacturing a polymer-based microneedle patch designed to maximize skin penetration performance. The polymer-based microneedle patch of the present disclosure can be manufactured to have enhanced penetration power and flexibility as microneedles formed of a polymer with both rigidity and flexibility are combined with an elastic and breathable substrate.

MEDICATION TRACKING

Resumen de: US2025316367A1

A system and method is described for printing a label with an RFID tag. The system includes an RFID reader that queries a first RFID tag coupled to a first medicinal container that includes a medication. In response, the system receives a first unique identifier and uses the first unique identifier to determine a status of the medication, associate the first medicinal container with a medical provider and print a second label that includes a second RFID tag for a second medicinal container.

Integrally formed medical devices

Resumen de: AU2025234230A1

INTEGRALLY FORMED MEDICAL DEVICES Abstract Disclosed herein are integrally formed medical devices and methods relating thereto. One embodiment provides an integrally formed patient-specific medical device comprising: a substantially trapezoidal body portion having at least one surface that is contoured to fit an anatomy of a patient; and a graft window defining a vertical aperture through said body portion, such that said body portion defines a cage. INTEGRALLY FORMED MEDICAL DEVICES Abstract Disclosed herein are integrally formed medical devices and methods relating thereto. One embodiment provides an integrally formed patient-specific medical device comprising: a substantially trapezoidal body portion having at least one surface that is contoured to fit an anatomy of a patient; and a graft window defining a vertical aperture through said body portion, such that said body portion defines a cage. ep e p b s t r a c t i s c l o s e d h e r e i n a r e i n t e g r a l l y f o r m e d m e d i c a l d e v i c e s a n d m e t h o d s r e l a t i n g t h e r e t o n e e m b o d i m e n t p r o v i d e s a n i n t e g r a l l y f o r m e d p a t i e n t - s p e c i f i c m e d i c a l d e v i c e c o m p r i s i n g : a s u b s t a n t i a l l y t r a p e z o i d a l b o d y p o r t i o n h a v i n g a t l e a s t o n e s u r f a c e t h a t i s c o n t o u r e d t o f i t a n a n a t o m y o f a p a t i e n t ; a n d a g r a f t w i n d o w d e f i n i n g a v e r t i c a l a p e r

BIOPRINTING METHODS AND SYSTEMS

Resumen de: AU2024230146A1

In a bioprinting system and method, a bioprinter may include one or more reservoirs, a printhead, and a print surface on which the bioprinting is dispensed. An optical system may collect imaging data of a plurality of cells within a cross-linkable material before, during and/or after passage of the plurality of cells through the bioprinting system. A computing system may process the imaging data to determine a quantity, distribution, concentration, and/or morphology of the plurality of cells. A machine learning system compares characteristics of the plurality of cells before, during and/or after passage of the plurality of cells through the bioprinting system to user-established cell morphologies corresponding to physical properties of cells and/or cell aggregates within a predetermined tolerance. Additionally or alternatively, the machine learning system compares characteristics of the plurality of cells at one stage in the bioprinting system to characteristics of the plurality of cells at another stage in the bioprinting system.

A MICROFLUIDIC DEVICE AND A METHOD OF FORMING THEREOF

Resumen de: AU2024233284A1

A method of manufacturing a patient-specific microfluidic device and a patient-specific microfluidic device are provided. The method includes obtaining three-dimensional (3D) information associated with vascular geometry in a region of interest from one or more clinical images associated with a patient, and fabricating the patient-specific microfluidic device using said 3D information. The patient-specific microfluidic device includes a flow channel having a geometry that substantially corresponds to the vascular geometry in the region of interest.

COMPACT ENDOSCOPE DESIGN FOR THREE-DIMENSIONAL SURGICAL GUIDANCE

Resumen de: US2025311915A1

The present invention is directed to endoscopic structure illumination to provide simple, inexpensive 3D endoscopic technique to conduct high resolution 3D imagery for use in surgical guidance system. The present invention is directed to an FPP endoscopic imaging setup which provides a wide field of view (FOV) that addresses a quantitative depth information and can be integrated with commercially available endoscopes to provide tissue profilometry. Furthermore, by adapting a flexible camera calibration method for the 3D reconstruction technique in free space, the present invention provides an optimal fringe pattern for the inner tissue profile capturing within the endoscopic view and validate the method using both static and dynamic samples that exhibits a depth of field (DOF) of approximately 20 mm and a relative accuracy of 0.1% using a customized printed calibration board. The presented designs enable flexibility in controlling the deviated angle necessary for single scope integration using FPP method.

SERIES OF DEVICES FOR PREPARING THE DISPLACEMENT, IN PARTICULAR A PERMANENT DISPLACEMENT, OF THE OCCLUSAL PLANE OF A PERSON, AND ASSOCIATED METHODS

Resumen de: US2025312125A1

A series (100) of devices for assisting in the displacement of the chewing plane of a person (P) is explained, comprisingat least two devices (10),wherein the devices (10) each comprise at least one jaw device (11, 12),wherein the at least one jaw device (11, 12) comprises an upper jaw device (11) and/or a lower jaw device (12),and wherein the devices (10) are designed to be worn by the person (P) according to a predetermined sequence.In at least one device (10.1, 10.2), the at least one jaw device (11, 12) comprises at least one height element on a first side. At least two contact areas, preferably local contact areas, are formed on the at least one height element at mutually different positions of molar elements. At least one further contact area is formed on a second side of the at least one jaw device (11, 12), in particular a further local contact area. The at least three contact areas define the plane (GE),wherein the plane (GE) deviates from a starting chewing plane of the person (P) or from a current chewing plane of the person (P) with respect to its inclination changed by the at least one height element in a frontal section or sagittal section and/or deviates with respect to its height position changed by the at least one height element, andwherein in at least one other device of the series (100) a different inclination in a frontal section or sagittal section and/or a different height position of the respective plane is adjusted by at least one further height eleme

SYSTEM FOR CONTROLLABLE RELEASE IN 3D-PRINTED COLON TARGETING (CORR3CT) ORAL DOSAGE FORM

Resumen de: US2025312281A1

An oral dosage form for controllable release and method of forming are described. The oral dosage form includes a core layer including an active ingredient and a plurality of outer shell layers surrounding the core layer, the plurality of outer shell layers configured to disintegrate at a pH above a threshold. The method of forming the oral dosage form includes forming a core formulation paste including an active ingredient and forming an outer shell formulation paste configured to disintegrate at a pH above a threshold. The method further includes forming a wet tablet by sequentially depositing the outer shell formulation paste and the core formulation paste. The wet tablet is subsequently dried and cooled to produce the oral dosage form.

Method for Modeling Humeral Anatomy and Optimization of Component Design

Resumen de: US2025312163A1

Stemless components and fracture stems for joint arthroplasty, such as shoulder arthroplasty, are disclosed. Also, methods and devices are disclosed for the optimization of shoulder arthroplasty component design through the use of medical imaging data, such as computed tomography scan data.

DENTAL IMPLANTS

Resumen de: US2025312130A1

The present teachings relate to an assembled dental implant comprising a metallic body manufactured at least partially via an additive manufacturing process: wherein the body is provided with a cavity having an opening on one end of the body. and an inlay part at least partly introduced within the cavity and scalably connected with the metallic body thereby sealing-off the cavity. The present teachings also relate to the metallic dental implant body and manufacturing methods.

MATRICES FOR WOUND HEALING

Resumen de: AU2023403078A1

The present invention provides articles for the improved healing of wounds, preferably burn wounds. In some preferred embodiments, the article is a matrix formed from a mixture of two or more polysaccharides, the matrix comprising an active ingredient which is an extract from differentiable cells.

RADIATION DOSIMETRY APPARATUS AND RELATED METHODS

Resumen de: WO2024113056A1

A radiation dosimetry apparatus comprises a body that supports scintillator elements that emit light when exposed to radiation. The body may be shaped to conform to contours of a portion of a patient's anatomy. Radiation intensity and dose may be determined by processing images obtained by one or more cameras to measure intensity of light emitted by different ones of the scintillator elements. The scintillator elements may be distributed non-uniformly based on a patient-specific radiation treatment plan. Scintillator elements may be arranged to provide increased spatial resolution and/or dose resolution in higher dose regions and/or regions corresponding to organs at risk. Radiation dosimeter apparatuses may be fabricated by additive manufacturing. Design and fabrication of the radiation dosimetry apparatuses may be integrated into workflows in clinical radiation treatment settings. Methods and systems for fabricating, calibrating, and using the radiation dosimetry apparatuses are described.

3D PRINTING OF HIGH CELL DENSITY VASCULARIZED TISSUE

Resumen de: WO2024118942A1

A composition and method for 3D bioprinting adds a contrast agent having a relatively high refractive index to a photopolymerizable bioink composition in which cells are encapsulated so that the refractive index of the composition substantially matches the refractive index of the encapsulated cells.

THREE-DIMENSIONAL TOOTH MODEL SEGMENTATION METHOD AND APPARATUS

Nº publicación: EP4629181A1 08/10/2025

Solicitante:

GUANGZHOU HEYGEARS IMC INC [CN]
Guangzhou Heygears IMC. Inc

Resumen de: EP4629181A1

The disclosure relates to a method and apparatus for cutting a three-dimensional tooth model. The method includes: obtaining a two-dimensional projection image of a three-dimensional tooth model, and recognizing the two-dimensional projection image to obtain a plurality of tooth regions, where the tooth regions correspond one to one to teeth; determining original seed points corresponding to the plurality of tooth regions in the three-dimensional tooth model; expanding the original seed points within a preset range to obtain target seed points of the teeth in the three-dimensional tooth model; and cutting the three-dimensional tooth model based on the target seed points of the teeth to obtain cut teeth. The present disclosure solves the technical problem of low tooth-cutting accuracy on the three-dimensional tooth model.