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54
resultados
Última actualización
07/12/2025 [06:45:00]
Resumen de: WO2025250650A1
The present disclosure relates to crystalline forms of N-(l-(tert-butyl)-lH-pyrazol-4-yl)-2-( 4-((6-((methylsulfonyl)quinolin-4-yl)oxy)-3-methylphenyl)acetamide of formula (II) and crystalline forms of salts thereof. The compound of formula (II) is a RIPK2 inhibitor for the treatment of e.g. inflammatory diseases, autoimmune diseases, granulomatous disease, neurodegenerative diseases or cancer, and more specifically for the treatment of inflammatory bowel disease, such as Crohn's disease or ulcerative colitis, rheumatoid arthritis, inflammatory arthritis, peritonitis, ischemia reperfusion injury in kidney transplant, non-alcohol steatohepatitis, alcohol steatohepatitis, insulin-resistant type 2 diabetes, allergic rhinitis, asthma, atopic dermatitis, Sjogren's syndrome, spondyloarthritis, ankylosing spondylitis, pemphigus vulgaris, idiopathic plasmacytic lymphadenopathy, atherosclerosis, myocardial infarction, thrombosis, alpha-synucleinopathy, Parkinson's disease, dementia with Lewy body, multiple system atrophy, Alzheimer's disease, amyotrophic lateral sclerosis, and chronic obstructive pulmonary disease
Resumen de: WO2025248072A1
The invention provides an antibody-drug conjugate comprising an anti-HER3 antibody or fragment thereof linked to a TOPO1 inhibitor drug via a linker unit, for use in treating a cancer selected from the group consisting of brain tumour, lung cancer, bladder cancer, stomach cancer, ovarian cancer, peritoneal cancer, pancreatic cancer, breast cancer, head and neck cancer, cervical cancer, endometrial cancer, liver cancer, kidney cancer, urothelial cancer, epidermal cancer, non-Hodgkin lymphoma, central nervous system tumour, or thyroid cancer; wherein the use comprises administering the antibody-drug conjugate or pharmaceutically acceptable salt thereof to a patient at a dose in the ranges as defined herein. Specific antibody-drug conjugates for use in treating breast cancer are also provided.
Resumen de: US2025372262A1
Disclosed herein, in certain embodiments, are systems and methods of detecting the presence of a skin condition using a machine learning model based on molecular risk factors. In some instances, the skin condition is cancer, such as cutaneous T cell lymphoma (CTCL). In some cases, the skin cancer can be mycosis fungoides (MF) or Sézary syndrome (SS).
Resumen de: US2025368712A1
Provided are methods of treating cancer (e.g., non-small cell lung cancer (NSCLC), head and neck squamous cell carcinoma (HNSCC), HER2-positive gastric/gastroesophageal junction (GEJ) cancer, de novo or transformed diffuse large B cell lymphoma (DLBCL), or indolent lymphoma) in an individual that comprise administering to the individual (a) a polypeptide comprising a SIRPα D1 domain variant and an Fc domain variant, and (b) an anti-cancer antibody (e.g., an anti-PD1 antibody, anti-HER2 antibody, or an anti-CD20 antibody). Also provided are related kits pharmaceutical compositions.
Resumen de: US2025368648A1
Some embodiments of the disclosure include inventive compounds (e.g., compounds of Formula (I)) and compositions (e.g., pharmaceutical compositions) which inhibit IRAK and/or FLT3 and which can be used for treating, for example, certain diseases. Some embodiments include methods of using the inventive compound (e.g., in compositions or in pharmaceutical compositions) for administering and treating (e.g., diseases such as hematopoietic cancers, myelodysplastic syndromes (MDS), acute myeloid leukemia (AML), etc.). Additional embodiments provide disease treatment using combinations of the inventive IRAK and/or FLT3 inhibiting compounds with other therapies, such as cancer therapies.
Resumen de: US2025368655A1
Provided are compounds of Formula (I) wherein X is selected from the group of ethanyl, ethenyl, ethynyl, and triazinyl; R1 is selected from the group of R1 is selected from the group of alkyl, alkoxy, cycloalkyl, —CH2-cycloalkyl, —O— cycloalkyl, halogen, haloalkyl, OH, and CN; and R2 is a ring moiety selected from the group of imidazolyl, pyrazolyl, 1,2,3-triazolyl, thiazolyl, phenyl, and pyridinyl, each optionally substituted; for use as inhibitors against native BCR-ABL kinase protein and clinically important BCR-ABL mutations such as T315I, F317L, E255K and Y253F for the treatment of diseases that include chronic myeloid leukemia (CML), acute lymphoblastic leukemia (ALL), and acute myelogenous leukemia (AML).
Resumen de: WO2025247377A1
The present application pertains to the field of medicinal chemistry and provides use of a sulfoximine compound for treating lymphoma. Specifically, the present application relates to use of a compound of formula (I) or a pharmaceutically acceptable salt thereof in the preparation of a medicament for treating lymphoma.
Resumen de: AU2024306742A1
Described herein is certain quinoline carboxamides for use in the treatment of a myeloproliferative neoplasm (MPN). The quinoline carboxamides may more specifically be used in the treatment of advanced stages of MPN, including accelerated-phase MPN and secondary acute myeloid leukemia, i.e., acute myeloid leukemia evolving from an antecedent myeloproliferative neoplasm (post-MPN AML), optionally in combination with a further compound selected from a Janus kinase (JAK) inhibitor, a bromodomain and extra-terminal motif protein (BET) inhibitor, a B-cell lymphoma 2 (Bcl-2) inhibitor, and combinations thereof. Also included are pharmaceutical combinations of the quinoline carboxamides and second agents such as a BET inhibitor or a Bcl-2 inhibitor. Further included are certain quinoline carboxamides for use in combination with a BET inhibitor or a Bcl-2 inhibitor, in the treatment of a myeloproliferative neoplasm (MPN).
Resumen de: AU2024257950A1
Embodiments of the present invention relate to methods of treating multiple myeloma in a subject in need thereof, comprising administering therapeutically effective amounts of a BCMAxCD3 bispecific antibody and a GPRC5DxCD3 bispecific antibody to the subject.
Resumen de: WO2025249980A1
The present invention relates to a therapy for preventing or treating lymphoma by administering poseltinib in combination with an immunomodulatory drug. In particular, the present invention achieves a synergistic effect on the prevention or treatment of diffuse large B-cell lymphoma and primary central nervous system lymphoma through the co-administration of poseltinib and lenalidomide.
Resumen de: AU2024257254A1
Embodiments of the present invention relate to methods of treating multiple myeloma in a subject in need thereof comprising administering to the subject a BCMAxCD3 bispecific antibody on a bi-weekly dosing schedule.
Resumen de: AU2024258892A1
The present invention relates to combinations comprising a therapeutically effective amount of a menin-mixed-lineage leukemia 1 (menin-MLL) inhibitor; and a therapeutically effective amount of a DNA intercalating agent and a pyrimidine analog; as well as to methods for treating a subject diagnosed with cancer using such combinations.
Resumen de: WO2025250667A1
The present disclosure relates to RIPK2 inhibitors of the formulae (I) or (II) for the treatment of e.g. inflammatory diseases, autoimmune diseases, granulomatous disease, neurodegenerative diseases or cancer, and, more specifically, for the treatment of inflammatory bowel disease, such as Crohn's disease or ulcerative colitis, rheumatoid arthritis, inflammatory arthritis, peritonitis, ischemia reperfusion injury in kidney transplant, non-alcohol steatohepatitis, alcohol steatohepatitis, insulin-resistant type 2 diabetes, allergic rhinitis, asthma, atopic dermatitis, Sjogren's syndrome, spondyloarthritis, ankylosing spondylitis, pemphigus vulgaris, idiopathic plasmacytic lymphadenopathy, atherosclerosis, myocardial infarction, thrombosis, alpha-synucleinopathy, Parkinson's disease, dementia with Lewy body, multiple system atrophy, Alzheimer's disease, amyotrophic lateral sclerosis, and chronic obstructive pulmonary disease.
Resumen de: WO2025248110A1
A method of treating BRAF mutant melanoma in a patient, including in a patient who is BRAF targeted therapy naïve, comprising administering a therapeutically effective amount of an oncolytic herpes simplex virus (HSV) and an anti-PD-1 antibody to the patient, wherein the oncolytic HSV comprises genes encoding (i) a glycoprotein from gibbon ape leukemia virus (GALV) from which the R peptide has been deleted (GALVR-) and (ii) GM-GSF.
Resumen de: WO2025248500A1
The present invention relates to antibodies that bind to ENPP3 and antibody-drug conjugates comprising an antibody that binds to ENPP3 conjugated to a drug, such as an auristatin. Also provided herein are methods for treating a solid tumor or leukemia comprising administering such ADCs.
Resumen de: EP4656205A1
Provided is a method for treating canine B-cell lymphoma that is more effective than conventional methods. The method for treating canine B-cell lymphoma includes administering an anti-canine CD20 monoclonal antibody in combination with a chemotherapeutic agent, simultaneously or sequentially. The chemotherapeutic agent is one or more of vincristine, cyclophosphamide, prednisolone, and doxorubicin. The monoclonal antibody against canine CD20 and the chemotherapeutic agent are administered in combination, simultaneously or sequentially.
Resumen de: MX2025008009A
This application pertains to the use of compounds, e.g., Compound A: or a pharmaceutically acceptable salt thereof, for the treatment of various diseases or disorders, including, for example, diffuse large B-cell lymphoma (DLBCL) and angioimmunoblastic T- cell lymphoma.
Resumen de: MX2025013022A
The invention provides methods of dosing for the treatment of cancers, such as multiple myelomas, with anti-fragment crystallizable receptor-like 5 (FcRH5)/anti-cluster of differentiation 3 (CD3) bispecific antibodies.
Resumen de: NZ787952A
Provided herein are methods for preparing, producing, processing, culturing, isolating, or making cells suitable for immune or cell therapy, and for their use in cell therapy for treating mantle cell lymphoma (MCL) or B cell acute lymphoblastic leukemia (ALL) in a subject in need thereof. The disclosure provides use of a therapeutically effective amount of comprising autologous T cells expressing an anti-CD19 chimeric antigen receptor (CAR) in the manufacture of a medicament for treating mantle cell lymphoma (MCL) or B cell acute lymphoblastic leukemia (ALL) in a subject in need thereof, wherein the anti-CD19 CAR comprises an anti-CD19 single-chain variable fragment (scFv) comprising the heavy chain and light chain variable regions of FMC63, a CD28 intracellular signaling region, and CD3-zeta signaling domain.
Resumen de: NZ748650A
The application provides methods for treating Hodgkin lymphoma or non Hodgkin lymphoma in a subject comprising nivolumab and brentuximab vedotin administered according to a dosage schedule, wherein the subject is to be administered: (i) brentuximab vedotin at a dose of about 1.8 mg/kg once every three weeks on day 1 of a first 21-day cycle; (ii) nivolumab at a dose of about 3 mg/kg on day 8 of the first 21-day cycle; and wherein a combination of brentuximab vedotin and nivolumab is to be administered on day 1 of each of a second 21-day cycle, a third 21-day cycle; and a fourth 21-day cycle, wherein the second 21-day cycle, the third 21-day cycle, and the fourth 21-day cycle follow in succession after the first 21-day cycle.
Resumen de: US2025360103A1
The present disclosure provides methods and pharmaceutical compositions for treating or slowing the progression of cancers that overexpress the histone methyltransferase WHSC1, e.g., t(4;14) multiple myeloma, by administrating to a subject in need thereof a therapeutically effective amount of an inhibitor of the histone methyltransferase, SETD2.
Resumen de: US2025362298A1
Methods of monitoring progression of multiple myeloma or plasmacytoma, particularly relapsed or refractory multiple myeloma, are described. Also described are methods of treating or determining response to a treatment for multiple myeloma or plasmacytoma in a subject.
Resumen de: AU2024258228A1
Provided herein are methods of treating a subject who has multiple myeloma and has received one to three prior treatment(s). Infusions of chimeric antigen receptor (CAR)-T cells comprising a CAR capable of specifically binding to an epitope of BCMA are administered to the subject.
Resumen de: AU2024283865A1
The present invention provides diagnostic methods, therapeutic methods, and compositions for the treatment of lymphoma (e.g., a diffuse large B-cell lymphoma (e.g., a germinal-center B-cell- like or activated B-cell-like diffuse large B-cell lymphoma). The invention is based, at least in part, on the discovery that macrophage biomarkers are useful in methods of identifying, diagnosing, or predicting the therapeutic efficacy of treatment with an anti-CD79b immunoconjugate (e.g., polatuzumab vedotin) and an anti-CD20 antibody (e.g., obinutuzumab or rituximab).
Nº publicación: WO2025244832A1 27/11/2025
Solicitante:
KONGS PHARMACEUTICAL CO [US]
KONG'S PHARMACEUTICAL CO
Resumen de: WO2025244832A1
The invention provides novel aminoguanidine compounds, pharmaceutical compositions and therapeutic uses thereof for treating various types of cancer (e.g., brain cancer, breast cancer, pancreatic cancer, renal cancer, lung cancer, leukemias, and lymphomas) and neurological disorders (e.g., Parkinson's disease, Alzheimer's disease, amyotrophic lateral sclerosis), and related diseases and conditions.
BOPI
Sede Electrónica
