Alerta

一种仿生矿化乳酸氧化酶LOD@CeZol纳米粒的制备方法及应用

Resumen de: CN122208550A

本发明公开了一种仿生矿化乳酸氧化酶LOD@CeZol纳米粒的制备方法及应用；属于纳米材料和骨衰老疾病治疗技术领域，其制备步骤：按比例先将一定量的乳酸氧化酶（LOD）在超纯水中溶解，然后滴加入含有唑来膦酸的10% Tris‑HCl溶液，之后将硝酸锌溶液滴加到上述混合溶液中进行原位矿化反应，经过离心、冷冻干燥后得LOD@CeZol纳米粒。本发明中LOD@CeZol纳米粒的乳酸氧化酶活性，过氧化氢酶活性构成级联反应，加上其本身的超氧化物歧化酶活性（SOD）和谷胱甘肽过氧化物酶活性（GPx），能够将退变髓核细胞中的超氧阴离子转化为无毒的氧气和水，从而缓解髓核细胞退变进程，更重要的是，LOD催化乳酸底物产生丙酮酸，能够显著降低髓核细胞内部堆积的乳酸含量，继而降低髓核细胞的乳酸化修饰水平，逆转髓核细胞的衰老退变。

一种仿生基质囊泡及其制备方法及在制备治疗骨质疏松或骨老化药物中的应用

Resumen de: CN122208552A

本发明涉及一种仿生基质囊泡及其制备方法及应用，具体涉及一种仿生基质囊泡及其制备方法及在制备治疗骨质疏松或骨老化药物中的应用。为解决现有技术存在靶向单一细胞内信号通路的干预策略，难以有效重塑整体细胞外稳态，导致骨再生能力下降治疗效果有限的不足之处，本发明一种仿生基质囊泡包括ALP‑nHA复合纳米颗粒以及包封在ALP‑nHA复合纳米颗粒外部的膜结构，所述膜结构为hMSCs膜；所述膜结构的表面设置有黏附或靶向特征，避免了现有技术中人工合成囊泡通常只携带单一药物或酶，或者只模拟膜结构，无法同时实现催化、成核、锚定的问题，同时，还提供了其制备方法及应用。

递送治疗剂的脂质化合物及其制备方法与应用

Resumen de: WO2025102261A1

Lipid compounds for delivering a therapeutic agent, a preparation method therefor and the use thereof. The lipid compounds are compounds with structural formula (I) or pharmaceutically acceptable forms thereof. The lipid compounds may be used in combination with other lipid components, such as neutral lipids, cholesterol, and polymer-bound lipids, so as to form lipid nanoparticles used for delivery of therapeutic agents (e.g. nucleic acid molecules) to achieve therapeutic or prophylactic purposes (e.g. vaccination), thus enriching the types of ionizable lipid compounds.

冻干的mRNA-LNP疫苗产品

Resumen de: WO2025098237A1

A lyophilized RNA-LNP (e.g., mRNA-lipid nanoparticle), a method of making or using the same, such as for vaccination using an mRNA encoding an antigenic vaccine (e.g., SARS-CoV-2).

用于制备包封药剂的脂质纳米颗粒的化合物、包含所述化合物的纳米颗粒组合物及其相关方法

Resumen de: WO2025080209A1

There is provided a compound represented by general formula (1) for preparing lipid nanoparticles encapsulating a therapeutic, prophylactic and/or biological agent: wherein AR comprises a unit from a poly(amino acid); R1 and R2 are each independently a hydrophobic group; R3, R4, and R5 are each independently H, optionally substituted alkyl, optionally substituted alkenyl or optionally substituted alkynyl; R7 is –H or –C(=O)R8, wherein R8 is optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl or optionally substituted alkoxy; m ≥ 1; and n ≥ 1.

受约束的可电离阳离子脂质和脂质纳米颗粒

Resumen de: US2025127728A1

Ionizable cationic lipids, methods for synthesizing the same, intermediates useful in synthesis of the ionizable cationic lipids and methods of synthesizing the intermediates are disclosed. The ionizable cationic lipids are useful as a component of lipid nanoparticles (LNP), which in turn can be used for the delivery of nucleic acids into cells in vivo or ex vivo. LNP compositions are also disclosed, including LNP comprising a functionalized lipid to enable conjugation of a binding moiety, and targeted LNP (tLNP), that is an LNP in which a binding moiety has been conjugated to the functionalized lipid and can serve as a targeting moiety to direct the tLNP to a desired tissue or cell type.

可降解的支化脂质组合物、其制备方法、包括其的脂质纳米颗粒(LNP)及其使用方法

Resumen de: WO2025059107A1

The present disclosure relates, in one aspect, to ionizable lipid compounds of formula (I). In another aspect, the present disclosure relates to the preparation of ionizable lipids of formula (I). In another aspect, the present disclosure relates to lipid nanoparticles (LNPs) comprising at least one ionizable lipid of formula (I), and methods of use thereof.

递送系统及其制备方法

Resumen de: WO2025057230A1

The present disclosure discloses particle including at least one bi-layer outer membrane, a plurality of vacuoles and at least one payload. The bi-layer outer membrane defining a lumen including an outer layer and an inner layer. Each of the outer layer and the inner layer define a hydrophobic portion and a hydrophilic portion. The outer layer including at least a plurality of cationic lipids, a plurality of neutral lipids, a plurality of helper lipid, and a plurality of polyethers. The vacuoles are disposed within the lumen defined by the bi-layer outer membrane. Each of the vacuole includes a membrane layer defining a lumen encapsulating the payload. Each of the membrane layer and the inner layer including at least the plurality of cationic lipids, the plurality of neutral lipids, and the plurality of helper lipids.

核酸送達に好適な脂質類

Resumen de: WO2022168085A1

The present invention provides lipids and lipid nanoparticle formulations comprising these lipids, alone or in combination with other lipids. These lipid nanoparticles may be formulated with nucleic acids to facilitate their intracellular delivery both in vitro and for therapeutic applications. The present invention also provides methods of chemical synthesis of these lipids, lipid nanoparticle preparation and formulation with nucleic acids.

原発性胆汁性胆管炎の治療のための寛容化ナノ粒子の調製

Resumen de: WO2024243410A1

The present disclosure relates to a process for the preparation of tolerizing immune modifying nanoparticles encapsulating antigens associated with primary biliary cholangitis (PBC), compositions comprising the particles and use thereof for the treatment of PBC.

저당 코로나바이러스 백신 및 이의 방법

Resumen de: WO2025080565A1

The present disclosure relates to a low glycosylated spike protein and a vaccine designed to express the spike protein in vivo. The present disclosure also teaches a method for generating an immune response by utilizing the low glycosylated spike protein, which provides a broader protection across different variants. A method for identifying a glycan-shielded conserved peptide of a glycoprotein is also disclosed.

MANUFACTURING METHOD FOR NANOPARTICLE USING AEROSOL BASED SYSTEM AND MEDICAL USE OF NANOPARTICLE MANUFACTURED THEREBY

Resumen de: KR20260089062A

본 발명은 에어로졸 기반 시스템을 이용한 나노입자 제조방법 및 이에 따라 제조된 나노입자의 의학적 용도에 관한 것으로, 단일 패스(single-pass)의 에어로졸 기반 나노입자 제조 시스템을 이용하여 간단하고 단순화된 공정으로 나노입자를 제조할 수 있다. 상기에 따라 제조된 나노입자는 매트릭스 표면이 지질로 코팅되고 내부는 약물과 광감작제가 봉입된 복합체 형태로, 체내 약물 전달과 효능을 향상시켜 적은 약물 용량으로도 우수한 치료 효과를 달성하면서 약물에 따른 부작용을 감소시킬 수 있다.

基于蛋白质-聚酯-脂质的核酸递送体系及其制备方法与应用

Resumen de: WO2026077099A1

Provided are a protein/polyester/lipid-nucleic acid delivery system for delivering a nucleic acid drug, a preparation method therefor, and use thereof. The system is prepared from an aqueous phase comprising a nucleic acid and a protein, and an organic phase comprising a hydrophobic degradable aliphatic polyester and a derivative thereof, and an ionizable lipid and/or a cationic lipid material. The preparation method comprises mixing an aqueous phase and an organic phase by using a single emulsification technology or a high-pressure homogenization technology to obtain a protein nanoassembly for targeted nucleic acid delivery. The protein is albumin or a single-chain antibody-albumin fusion protein. The stable protein nanoassembly is applied to a targeted nucleic acid delivery platform, and is applied to a nucleic acid treatment drug for tumors, autoimmune diseases, or inflammatory diseases.

用于治疗动脉粥样硬化的组合物的制药用途

Resumen de: CN111297895A

The invention discloses a pharmaceutical application of composition for treating atherosclerosis, and particularly relates to application of a composition comprising microvesicles and copper ions in preparation of a drug for treating the atherosclerosis. When the composition comprising the microvesicles and copper ions is used for treating the atherosclerosis, the plaque area is significantly reduced while plaque breakage and falling are not caused.

一种RNA胞内递送工具、系统及其应用

Resumen de: CN122182504A

本发明属于生物医药技术领域，本发明涉及一种RNA胞内递送工具、系统及其应用。本发明提供一种RNA胞内递送工具，所述RNA胞内递送工具包括：胞外可收缩注射系统和RNA结合蛋白。该递送工具中，RNA结合蛋白与货物RNA分子结合形成复合物，所述复合物被装载于胞外可收缩注射系统内部，形成RNA胞内递送系统。该递送系统以收缩注射的方式穿刺细胞并释放货物RNA分子至胞内，实现精准的RNA胞内递送。本发明克服了现有RNA递送技术的靶向性、高效性与安全性不足的问题，为RNA治疗提供解决方案。

一种硫辛酸掺杂脂质纳米颗粒及其制备方法和应用

Resumen de: CN122182509A

本发明提供了一种硫辛酸掺杂脂质纳米颗粒及其制备方法和应用，属于生物医药技术领域。本发明提供的硫辛酸掺杂脂质纳米颗粒由核酸药物和脂质组合物两部分组成，所述脂质组合物由可电离脂质、甾醇、PEG化脂质、辅助脂质、硫辛酸五部分组成。本发明的有益效果在于通过在传统四组分脂质纳米颗粒中引入硫辛酸即可增强其核酸药物递送效果，并且在实现高效核酸药物转染的同时不会引起明显的细胞毒性，具有较高的生物安全性。

一种促进肾组织修复的纳米药物及制备方法和应用

Resumen de: CN122182507A

本发明属于药物制备技术领域，具体涉及一种促进肾组织修复的纳米药物及制备方法和应用。所述纳米药物是将灯笼草碱负载于载体上，得到载药纳米粒；在载药纳米粒外部包覆红细胞膜后，并修饰Megalin受体靶向肽得到。本发明中的纳米药物能够协同解决靶向富集、循环长效、缓释控释及药物效能四大核心技术问题。

提高可雾化脂质纳米颗粒稳定性的永久阳离子脂质及其应用

Resumen de: CN122187682A

本发明提供一种提高可雾化脂质纳米颗粒稳定性的永久阳离子脂质及其应用，该永久阳离子脂质由两条长脂肪链、季胺头基以及中间的连接基团组成，通过改变中间的连接基团的部分，调整季胺头基到连接基团的距离，筛选出目标化合物，解决现有技术中正电荷脂质难以兼顾肺部靶向性与雾化稳定性的技术问题。

一种空心金属多酚载药体系及其制备方法

Resumen de: CN122182506A

本发明公开了一种空心金属多酚载药体系及其制备方法。空心金属多酚载药体系包括空心金属多酚EGCG‑Mg纳米颗粒，该纳米颗粒具有EGCG与Mg2+配位形成的微孔和/或介孔金属多酚网络。制备方法包括：将有机相中合成的载药ZIF‑8纳米颗粒分散于有机相中，得到载药ZIF‑8纳米颗粒分散液；在搅拌下，将EGCG有机溶液和Mg2+有机溶液加入到载药ZIF‑8纳米颗粒分散液中进行反应，得到核壳结构纳米颗粒；将核壳结构纳米颗粒分散于pH=7.0水相缓冲液中，有机相中合成的ZIF‑8会在水相缓冲液中降解，使ZIF‑8核心分解并通过壳层孔隙扩散出去，形成空心金属多酚EGCG‑Mg纳米颗粒。

一种刷状结构屏障适配型核酸药物递送系统及其制备方法和应用

Resumen de: CN122182792A

本发明公开了一种刷状结构屏障适配型核酸药物递送系统及其制备方法和应用，属于高分子化学和生物医药技术领域，该递送系统由聚双硫主链、经修饰的核酸药物和经修饰的聚两性离子发生点击反应或环加成反应制备得到；聚双硫主链为无规共聚物，包括双硫结构单元A和丙烯酸酯结构单元B，双硫结构单元A由硫辛酸开环聚合形成，修饰有点击反应官能团或环加成反应官能团；经修饰的核酸药物的至少一个碱基上修饰有点击反应官能团或环加成反应官能团；经修饰的聚两性离子上修饰有点击反应官能团或环加成反应官能团；该递送系统能够赋予核酸药物突破皮肤及黏液屏障的能力，且根据搭载的核酸药物种类和数量的不同，可用于多种疾病的治疗或预防。

可电离阳离子脂质及其脂质纳米颗粒

Resumen de: WO2025104695A1

Provided herein are ionizable lipids of the following structural formula: (I), or a pharmaceutically acceptable salt, solvate, or hydrate thereof, wherein values for the variables (e.g., G1, G2, L1, L2, M1, M2, R1, R2, R3, R4) are as described herein. Also provided are lipid nanoparticles comprising ionizable lipids of Formula (I), or a pharmaceutically acceptable salt, solvate, or hydrate thereof, and methods of using the ionizable lipids, e.g., to administer therapy to a subject in need thereof.

治疗神经变性障碍的方法

Resumen de: WO2025106874A1

Provided herein are expression cassettes for expressing a transgene in a cell, wherein the transgene encodes a disorder-related polypeptide. Also provided are methods to treat various neurodegenerative disorders. Further provided herein are vectors (e.g., rAAV vectors), viral particles, pharmaceutical compositions and kits for expressing a disorder-related polypeptide in an individual in need thereof.

基于丙烯酸烷基酯的多肽-脂质复合物递送系统及其制备方法和应用

Resumen de: CN122182503A

本发明涉及生物医药技术领域，尤其涉及基于丙烯酸烷基酯的多肽‑脂质复合物递送系统及其制备方法和应用。提供了两种不同结构的多肽片段，并通过两种不同的修饰方法形成新型的多肽‑脂质复合物，利用该新型多肽‑脂质复合物与基于丙烯酸烷基酯的可电离脂质形成的递送系统，可实现对siRNA和mRNA等多种RNA分子在难转染细胞系中的高效转染。体外实验结果表明：多肽‑脂质复合物递送系统能够在多种细胞系中高效递送RNA分子，且具有低毒性；体内动物实验结果表明：多肽‑脂质复合物递送系统，在肝和脾靶组织中选择性高效表达。本发明提供的制备方法过程简单、条件可控，有利于临床的转化与生产。

一种巨噬细胞膜包裹的生物功能化磷化钙纳米材料及其制备方法和应用

Resumen de: CN122182505A

本发明公开了一种巨噬细胞膜包裹的生物功能化磷化钙（CaP）纳米材料及其制备方法和应用，属于生物医药和纳米材料技术领域，本发明用巨噬细胞膜包裹生物功能化CaP纳米材料，制备的巨噬细胞膜包裹的生物功能化CaP纳米材料具有很好的体内抗炎活性，能有效清除炎症微环境过量活性氧，减少氧化应激，并且巨噬细胞膜表面具有炎症因子识别受体，对炎症部位具有很好的靶向性，能够使纳米材料在炎症部位有效积累。经生物实验证实，该巨噬细胞膜包裹的生物功能化CaP纳米材料可以用于抗菌、抗炎治疗，其细胞膜结构还能协助纳米材料逃离免疫系统，具有良好生物安全性，是药物运输和缓释的理想载体。

青蒿素用于口腔炎症管理的闭环控制智能给药系统

Nº publicación: CN122182510A 12/06/2026

Solicitante:

中国人民解放军海军军医大学