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Solicitudes publicadas en los últimos 60 días / Applications published in the last 60 days
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阿尔茨海默病血液标志物pTau217的化学发光检测试剂盒及其应用

NºPublicación:  CN121679036A 17/03/2026
Solicitante: 
江苏默乐生物科技股份有限公司
CN_121679036_PA

Resumen de: EP1000000A1

The invention relates to an apparatus (1) for manufacturing green bricks from clay for the brick manufacturing industry, comprising a circulating conveyor (3) carrying mould containers combined to mould container parts (4), a reservoir (5) for clay arranged above the mould containers, means for carrying clay out of the reservoir (5) into the mould containers, means (9) for pressing and trimming clay in the mould containers, means (11) for supplying and placing take-off plates for the green bricks (13) and means for discharging green bricks released from the mould containers, characterized in that the apparatus further comprises means (22) for moving the mould container parts (4) filled with green bricks such that a protruding edge is formed on at least one side of the green bricks.

Composition for predicting permeability of Blood-Brain Barrier

NºPublicación:  KR20260037573A 17/03/2026
Solicitante: 
연세대학교산학협력단
KR_20260037573_PA

Resumen de: EP1000000A1

The invention relates to an apparatus (1) for manufacturing green bricks from clay for the brick manufacturing industry, comprising a circulating conveyor (3) carrying mould containers combined to mould container parts (4), a reservoir (5) for clay arranged above the mould containers, means for carrying clay out of the reservoir (5) into the mould containers, means (9) for pressing and trimming clay in the mould containers, means (11) for supplying and placing take-off plates for the green bricks (13) and means for discharging green bricks released from the mould containers, characterized in that the apparatus further comprises means (22) for moving the mould container parts (4) filled with green bricks such that a protruding edge is formed on at least one side of the green bricks.

一种基于单分子免疫法检测APOE3和/或APOE4的试剂组合及其应用

NºPublicación:  CN121679041A 17/03/2026
Solicitante: 
合肥国研汉因检测科技有限公司
CN_121679041_PA

Resumen de: EP1000000A1

The invention relates to an apparatus (1) for manufacturing green bricks from clay for the brick manufacturing industry, comprising a circulating conveyor (3) carrying mould containers combined to mould container parts (4), a reservoir (5) for clay arranged above the mould containers, means for carrying clay out of the reservoir (5) into the mould containers, means (9) for pressing and trimming clay in the mould containers, means (11) for supplying and placing take-off plates for the green bricks (13) and means for discharging green bricks released from the mould containers, characterized in that the apparatus further comprises means (22) for moving the mould container parts (4) filled with green bricks such that a protruding edge is formed on at least one side of the green bricks.

三重陰性乳癌を予測および治療するための方法および組成物

NºPublicación:  JP2026509039A 17/03/2026
Solicitante: 
シービーエスバイオサイエンスカンパニーリミテッド
JP_2026509039_A

Resumen de: EP1000000A1

The invention relates to an apparatus (1) for manufacturing green bricks from clay for the brick manufacturing industry, comprising a circulating conveyor (3) carrying mould containers combined to mould container parts (4), a reservoir (5) for clay arranged above the mould containers, means for carrying clay out of the reservoir (5) into the mould containers, means (9) for pressing and trimming clay in the mould containers, means (11) for supplying and placing take-off plates for the green bricks (13) and means for discharging green bricks released from the mould containers, characterized in that the apparatus further comprises means (22) for moving the mould container parts (4) filled with green bricks such that a protruding edge is formed on at least one side of the green bricks.

ONOO- Multifunctional fluorescent probes for successively detection of endogenous ONOO- and mitochondrial viscosity

NºPublicación:  KR20260036808A 17/03/2026
Solicitante: 
국립강릉원주대학교산학협력단
KR_20260036808_PA

Resumen de: EP1000000A1

The invention relates to an apparatus (1) for manufacturing green bricks from clay for the brick manufacturing industry, comprising a circulating conveyor (3) carrying mould containers combined to mould container parts (4), a reservoir (5) for clay arranged above the mould containers, means for carrying clay out of the reservoir (5) into the mould containers, means (9) for pressing and trimming clay in the mould containers, means (11) for supplying and placing take-off plates for the green bricks (13) and means for discharging green bricks released from the mould containers, characterized in that the apparatus further comprises means (22) for moving the mould container parts (4) filled with green bricks such that a protruding edge is formed on at least one side of the green bricks.

一种免标记FRET增强型荧光组胺RNA生物传感器

NºPublicación:  CN121674405A 17/03/2026
Solicitante: 
中国农业大学
CN_121674405_PA

Resumen de: EP1000000A1

The invention relates to an apparatus (1) for manufacturing green bricks from clay for the brick manufacturing industry, comprising a circulating conveyor (3) carrying mould containers combined to mould container parts (4), a reservoir (5) for clay arranged above the mould containers, means for carrying clay out of the reservoir (5) into the mould containers, means (9) for pressing and trimming clay in the mould containers, means (11) for supplying and placing take-off plates for the green bricks (13) and means for discharging green bricks released from the mould containers, characterized in that the apparatus further comprises means (22) for moving the mould container parts (4) filled with green bricks such that a protruding edge is formed on at least one side of the green bricks.

Fluorescent Probes for Fluoride Ion Detection

NºPublicación:  KR20260036809A 17/03/2026
Solicitante: 
국립강릉원주대학교산학협력단
KR_20260036809_PA

Resumen de: EP1000000A1

The invention relates to an apparatus (1) for manufacturing green bricks from clay for the brick manufacturing industry, comprising a circulating conveyor (3) carrying mould containers combined to mould container parts (4), a reservoir (5) for clay arranged above the mould containers, means for carrying clay out of the reservoir (5) into the mould containers, means (9) for pressing and trimming clay in the mould containers, means (11) for supplying and placing take-off plates for the green bricks (13) and means for discharging green bricks released from the mould containers, characterized in that the apparatus further comprises means (22) for moving the mould container parts (4) filled with green bricks such that a protruding edge is formed on at least one side of the green bricks.

慢性的ストレス状態を評価するためのバイオマーカーパネル

NºPublicación:  JP2026048281A 17/03/2026
Solicitante: 
国立研究開発法人産業技術総合研究所
JP_2026048281_A

Resumen de: EP1000000A1

The invention relates to an apparatus (1) for manufacturing green bricks from clay for the brick manufacturing industry, comprising a circulating conveyor (3) carrying mould containers combined to mould container parts (4), a reservoir (5) for clay arranged above the mould containers, means for carrying clay out of the reservoir (5) into the mould containers, means (9) for pressing and trimming clay in the mould containers, means (11) for supplying and placing take-off plates for the green bricks (13) and means for discharging green bricks released from the mould containers, characterized in that the apparatus further comprises means (22) for moving the mould container parts (4) filled with green bricks such that a protruding edge is formed on at least one side of the green bricks.

抗TDP-43結合分子およびその使用

NºPublicación:  JP2026509262A 17/03/2026
Solicitante: 
エイシーイミューンソシエテアノニム
JP_2026509262_A

Resumen de: EP1000000A1

The invention relates to an apparatus (1) for manufacturing green bricks from clay for the brick manufacturing industry, comprising a circulating conveyor (3) carrying mould containers combined to mould container parts (4), a reservoir (5) for clay arranged above the mould containers, means for carrying clay out of the reservoir (5) into the mould containers, means (9) for pressing and trimming clay in the mould containers, means (11) for supplying and placing take-off plates for the green bricks (13) and means for discharging green bricks released from the mould containers, characterized in that the apparatus further comprises means (22) for moving the mould container parts (4) filled with green bricks such that a protruding edge is formed on at least one side of the green bricks.

补体相关性疾病靶向防治全自动分析仪检测补体的试剂盒及方法

NºPublicación:  CN121679030A 17/03/2026
Solicitante: 
杭州康知生物科技有限公司
CN_121679030_PA

Resumen de: EP1000000A1

The invention relates to an apparatus (1) for manufacturing green bricks from clay for the brick manufacturing industry, comprising a circulating conveyor (3) carrying mould containers combined to mould container parts (4), a reservoir (5) for clay arranged above the mould containers, means for carrying clay out of the reservoir (5) into the mould containers, means (9) for pressing and trimming clay in the mould containers, means (11) for supplying and placing take-off plates for the green bricks (13) and means for discharging green bricks released from the mould containers, characterized in that the apparatus further comprises means (22) for moving the mould container parts (4) filled with green bricks such that a protruding edge is formed on at least one side of the green bricks.

神经系统疾病特别是运动神经元疾病的肽生物标志物

NºPublicación:  CN121666456A 13/03/2026
Solicitante: 
豪夫迈·罗氏有限公司
CN_121666456_A

Resumen de: US2018099049A1

Stable lyophilized therapeutic protein compositions and their methods of manufacture are provided. Specifically, the use of water as a solid cake plasticizer and protein stabilizer is described. Also, the inclusion of a multicomponent stabilizer comprising a larger molecular entity and a smaller molecular entity is described. Also, the inclusion of post-drying annealing under certain conditions improves protein stability. Proteins are predicted to remain stable over 24 months at 25° C.

响应面法优化萌芽核桃种子蛋白最佳缓冲液萃取试验方法

NºPublicación:  CN121655982A 13/03/2026
Solicitante: 
四川农业大学
CN_121655982_PA

Resumen de: EP1000000A1

The invention relates to an apparatus (1) for manufacturing green bricks from clay for the brick manufacturing industry, comprising a circulating conveyor (3) carrying mould containers combined to mould container parts (4), a reservoir (5) for clay arranged above the mould containers, means for carrying clay out of the reservoir (5) into the mould containers, means (9) for pressing and trimming clay in the mould containers, means (11) for supplying and placing take-off plates for the green bricks (13) and means for discharging green bricks released from the mould containers, characterized in that the apparatus further comprises means (22) for moving the mould container parts (4) filled with green bricks such that a protruding edge is formed on at least one side of the green bricks.

TRPM7激活剂在制备阿尔茨海默病治疗产品中的应用

NºPublicación:  CN121648293A 13/03/2026
Solicitante: 
复旦大学
CN_121648293_A

Resumen de: EP1000000A1

The invention relates to an apparatus (1) for manufacturing green bricks from clay for the brick manufacturing industry, comprising a circulating conveyor (3) carrying mould containers combined to mould container parts (4), a reservoir (5) for clay arranged above the mould containers, means for carrying clay out of the reservoir (5) into the mould containers, means (9) for pressing and trimming clay in the mould containers, means (11) for supplying and placing take-off plates for the green bricks (13) and means for discharging green bricks released from the mould containers, characterized in that the apparatus further comprises means (22) for moving the mould container parts (4) filled with green bricks such that a protruding edge is formed on at least one side of the green bricks.

核桃肽在制备认知功能改善剂中的应用

NºPublicación:  CN121648252A 13/03/2026
Solicitante: 
南昌大学
CN_121648252_PA

Resumen de: EP1000000A1

The invention relates to an apparatus (1) for manufacturing green bricks from clay for the brick manufacturing industry, comprising a circulating conveyor (3) carrying mould containers combined to mould container parts (4), a reservoir (5) for clay arranged above the mould containers, means for carrying clay out of the reservoir (5) into the mould containers, means (9) for pressing and trimming clay in the mould containers, means (11) for supplying and placing take-off plates for the green bricks (13) and means for discharging green bricks released from the mould containers, characterized in that the apparatus further comprises means (22) for moving the mould container parts (4) filled with green bricks such that a protruding edge is formed on at least one side of the green bricks.

Universal Efficient Dextran Microparticles Production with Microfluidic Technology

NºPublicación:  US20260071176A1 12/03/2026
Solicitante: 
SANOFI SA [FR]
PASTEUR INSTITUT [FR]
COMMISSARIAT ENERGIE ATOMIQUE [FR]
US_20260071176_PA

Resumen de: US20260071176A1

0000 The present invention relates to the use of modified dextran hydrogel microparticles comprising (i) at least one vinyl sulfone functionalized dextran, and (ii) at least one crosslinkable polymer having at least two thiol functions, wherein the dextran has a molecular weight comprised between 5 and 500 kDa, and the substitution degree of the dextran by the vinyl sulfone is comprised between 5 and 60%, for encapsulating at least one synthetic or natural cell. The present invention also relates to modified dextran hydrogel microparticles, a process for preparing them, an in vitro method for cultivating at least one cell comprised in said microparticles, in vitro methods for screening, for producing or for testing compounds, a kit, a microfluidic or millifluidic channel, a process for encapsulating said microparticles, and a method for the quality control of a batch. Said microparticles are useful in the field of biological and medical applications.

METHODS AND COMPOSITIONS FOR T CELL THERAPY

NºPublicación:  US20260072034A1 12/03/2026
Solicitante: 
KITE PHARMA INC [US]
US_20260072034_PA

Resumen de: US20260072034A1

0000 The disclosure relates to methods of diagnosis and prognosis, compositions for immunotherapies, methods of improving said compositions, and immunotherapies using the same

METHODS OF USING NEUROFILAMENT LIGHT CHAIN IMMUNOASSAYS

NºPublicación:  AU2024366503A1 12/03/2026
Solicitante: 
SIEMENS HEALTHCARE DIAGNOSTICS INC
SIEMENS HEALTHCARE DIAGNOSTICS INC
AU_2024366503_PA

Resumen de: AU2024366503A1

Methods, kits and compositions of detecting analytes, typically analytes relevant to neurodegenerative diseases such as neurofilament light chain, in a sample are described herein using chemiluminescent labels. Solid supports, reagents, and compounds for use in these methods are also described. Typically, the methods involve specific assay formats which provide the requisite high resolution for detecting low concentrations of analytes in samples and may be used in positions of the healthcare ecosystem close to the patient. These methods, systems, and apparatuses may afford early detection and prognosis of a wide variety of neurodegenerative diseases such as Alzheimer's disease and multiple sclerosis.

DEVICE FOR PERSONAL PREDICTIVE ENRICHMENT OF A BIOMARKER AND METHODS OF USE THEREOF

NºPublicación:  US20260072023A1 12/03/2026
Solicitante: 
KELLY SEAN M [US]
US_20260072023_PA

Resumen de: US20260072023A1

Methods and devices for enriching a target biomarker from a bodily fluid of a subject are provided. A risk profile for the subject is used to predict that a target biomarker is present in the bodily fluid. The bodily fluid is contacted with a set of immuno-affinity inserts coated with affinity molecules specific for the target biomarker under conditions for the affinity molecules to bind the target biomarker. The affinity molecules bound to the target biomarker are separated from the bodily fluid.

METHODS FOR AIDING IN DIAGNOSING AND EVALUATING A TRAUMATIC BRAIN INJURY IN A HUMAN SUBJECT USING A COMBINATION OF GFAP AND UCH-L1

NºPublicación:  US20260072042A1 12/03/2026
Solicitante: 
ABBOTT LAB [US]
US_20260072042_PA

Resumen de: US20260072042A1

0000 Disclosed herein are methods of aiding in the diagnosis and evaluation of a subject that has sustained or may have sustained an injury to the head. For example, the present disclosure provides methods for aiding in the diagnosis and evaluation of a subject to determine whether the subject has sustained a traumatic brain injury (TBI) by detecting or measuring a combination of the levels of ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) and glial fibrillary acidic protein (GFAP) in samples taken at various time points within 48 hours after the subject has sustained or may have sustained an injury to the head.

METHOD OF DETERMINING THE PRESENCE OR ABSENCE OF A TARGET ANALYTE COMPRISING USING A REPORTER POLYNUCLEOTIDE AND A TRANSMEMBRANE PORE

NºPublicación:  US20260072019A1 12/03/2026
Solicitante: 
OXFORD NANOPORE TECH PLC [GB]
US_20260072019_PA

Resumen de: US20260072019A1

The invention relates to a method of determining the presence or absence of a target analyte in a sample. The method comprises immobilising any target analyte present in the sample on a surface; contacting the surface with: (i) a first detection agent that binds specifically to the target analyte; and (ii) a reporter polynucleotide, wherein the reporter polynucleotide is bound to, or binds to, the first detection agent; and contacting a transmembrane pore with any reporter polynucleotide that has been immobilised on the surface, wherein the reporter polynucleotide is immobilised on the surface by binding of the first agent to the target analyte, and using the transmembrane pore to detect the reporter polynucleotide, thereby determining the presence or absence of the target analyte in the sample.

Protein biomarkers for diseases associated with the contact activation system

NºPublicación:  AU2026201253A1 12/03/2026
Solicitante: 
TAKEDA PHARMACEUTICALS CO [JP]
AU_2026201253_A1

Resumen de: AU2026201253A1

Provided herein are methods and kits for analyzing a biological sample obtained from a subject having, suspected of having, or being at risk for a disease associated with the contact activation system. eb e b

PRODUCTION METHOD OF NERVE CELLS DAMAGED BY OXIDATIVE STRESS AND APPLICATIONS THEREOF

NºPublicación:  US20260071179A1 12/03/2026
Solicitante: 
FUJIFILM CORP [JP]
US_20260071179_PA

Resumen de: US20260071179A1

An object of the present invention is to provide a method for producing nerve cells damaged by oxidative stress from a human-derived pluripotent stem cell; a culturing method for cells that allows nerve cells damaged by oxidative stress to be produced from a human-derived pluripotent stem cell; nerve cells damaged by oxidative stress; an evaluation method for a test substance, a screening method for a drug for prevention and/or treatment of a neurodegenerative disease, a screening method for a necroptosis inhibitor, and a screening method for a ferroptosis inhibitor, which use the nerve cells.According to the present invention, there is provided a production method of nerve cells damaged by oxidative stress, the method including a step a of seeding nerve cells obtained by differentiation from a human-derived pluripotent stem cell, at a cell density of 20.0×104 cells/cm2 or less by using a culture medium that substantially does not contain an antioxidant and substantially does not contain an oxidant and a step b of culturing the nerve cells by using the culture medium that substantially does not contain an antioxidant and substantially does not contain an oxidant.

Nutritive Polypeptides and Formulations Thereof, and Methods of Production and Use Thereof

NºPublicación:  US20260069656A1 12/03/2026
Solicitante: 
AXCELLA HEALTH INC [US]
US_20260069656_A1

Resumen de: US20260069656A1

0000 Nutritive Polypeptides are provided herein. Also provided are various other embodiments including nucleic acids encoding the polypeptides, recombinant microorganisms that make the polypeptides, vectors for expressing the polypeptides, methods of making the polypeptides using recombinant microorganisms, compositions and formulations that comprise the polypeptides, and methods of using the polypeptides, compositions and formulations.

PROTEIN MARKERS FOR NEURODEGENERATIVE DISEASES

NºPublicación:  WO2026051874A1 12/03/2026
Solicitante: 
THE HONG KONG UNIV OF SCIENCE AND TECHNOLOGY [CN]
HONG KONG CENTER FOR NEURODEGENERATIVE DISEASES LTD [CN]
THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY,
HONG KONG CENTER FOR NEURODEGENERATIVE DISEASES LIMITED
WO_2026051874_PA

Resumen de: WO2026051874A1

Provided are diagnostic and treatment methods,based on plasma protein markers for neurodegenerative diseases such as mild cognitive impairment (MCI) and Alzheimer's Disease (AD),as well as kits for diagnosing and/or treating these condition.Machine learning systems and methods for assessing the risk for a subject having a neurodegenerative disease based on measured protein marker levels are also provided.

STABILIZED CIRCULATING PEPTIDES AND USES THEREOF

Nº publicación: WO2026055173A1 12/03/2026

Solicitante:

HALCYON THERAPEUTICS INC [US]
HALCYON THERAPEUTICS, INC

WO_2026055173_PA

Resumen de: WO2026055173A1

The present invention provides a method for identifying a subject having a stabilized circulating peptide. The method comprises detecting the stabilized circulating peptide in a body fluid sample, for example, a serum or plasma sample, from the subject. The method may further comprise treating a neurodegenerative disease, or monitoring or adjusting a treatment of a neurodegenerative disease. Also provided is a kit. The kit comprises a binding protein that specifically binds a stabilized circulating peptide in a body fluid sample, for example, a serum or plasma sample, from a subject. The kit may further comprise an agent for detecting, treating or monitoring a neurodegenerative disease in the subject. The neurodegenerative disease may be Alzheimer disease.

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