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LastUpdate Última actualización 28/08/2026 [07:44:00]
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Solicitudes publicadas en los últimos 60 días / Last 60 days publications
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Application of PRAS40 protein as Alzheimer's disease treatment target

NºPublicación:  CN122297679A 30/06/2026
Solicitante: 
PEKING UNIVERSITY MENTAL HEALTH RESEARCH INST PEKING UNIVERSITY SIXTH HOSPITAL
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CN_122297679_PA

Resumen de: CN122297679A

The invention relates to the technical field of molecular biology, in particular to application of PRAS40 protein as an Alzheimer's disease treatment target. According to the present invention, with the combination of western blot verification, computer virtual docking, surface plasmon resonance (SPR) and other technical means, the PRAS40 protein is proved to be the key target spot affecting the AD pathological process; experimental results show that specific intervention (elimination or reduction) of the PRAS40 protein level is sufficient to significantly improve cognitive defects and pathological characteristics of AD model mice, so that a clear molecular target is provided for subsequent screening and development of novel anti-AD drugs.

Vietnam camellia oleosa seed oil self-microemulsion preparation, piperine self-microemulsion preparation taking Vietnam camellia oleosa seed oil as oil phase, and preparation method and application of piperine self-microemulsion preparation

NºPublicación:  CN122297390A 30/06/2026
Solicitante: 
UNIV CAPITAL MEDICAL SCIENCES
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CN_122297390_PA

Resumen de: CN122297390A

The invention relates to a Vietnam camellia oleosa seed oil self-microemulsion preparation, a piperine self-microemulsion preparation taking Vietnam camellia oleosa seed oil as an oil phase as well as a preparation method and application of the piperine self-microemulsion preparation. The Vietnam camellia oleosa seed oil self-microemulsion preparation with an optimal prescription and the piperine self-microemulsion preparation taking the Vietnam camellia oleosa seed oil as the oil phase are prepared through prescription screening and optimization. An in-vitro cell experiment and an in-vivo pharmacodynamic experiment show that the Vietnam camellia oleosa seed oil self-microemulsion preparation has neuroprotective activity, can relieve nerve cell injury in a cerebral region of a Parkinson's disease model rat, can also improve dyskinesia of the Parkinson's disease model rat, and can increase the content of DA, DOPAC and HVA in injured side striatum of the Parkinson's disease model rat, so that the Vietnam camellia oleosa seed oil self-microemulsion preparation can be used for treating Parkinson's disease. After the piperine is combined with the piperine, the improvement effect of the piperine on the Parkinson's disease is enhanced, a good synergistic effect is shown, and a new treatment means is provided for treatment of the Parkinson's disease.

Application of lactobacillus plantarum in prevention and treatment of Alzheimer disease

Nº publicación: CN122303098A 30/06/2026

Solicitante:

OUJIANG LABORATORY
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CN_122303098_PA

Resumen de: CN122303098A

The invention provides a lactobacillus plantarum HLP0106 and application of the lactobacillus plantarum HLP0106 or a fermentation product of the lactobacillus plantarum HLP0106 in prevention and/or treatment of Alzheimer's disease.

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