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161
resultados
Última actualización
27/06/2026 [08:18:00]
Resultados 150 a 161 de 161
Resumen de: WO2026088070A1
The present invention relates to novel compounds and pharmaceutical compositions. More particularly, the present invention provides novel compounds which are useful for the treatment of and prevention of neurodegenerative disorders including, but not limited to, Alzheimer's Disease (AD), Parkinson's Disease (PD), Amyotrophic Lateral Sclerosis (ALS), Frontotemporal Dementia (FTD), and Nasu-Hakola Disease (NHD).
Resumen de: WO2026087399A1
The invention relates to a compound of formula (I) that reduce the protein level of huntingtin (HTT) and which are useful in the treatment of Huntington's disease.
Resumen de: WO2026088136A1
The present disclosure provides a method of treating a neurodegenerative disease such as Alzheimer's disease in a subject. The method includes administering to the subject about 30 mg of AR1001 orally once daily, or a pharmaceutically acceptable salt thereof, and monitoring plasma phosphorylated tau 181 (pTau181) or phosphorylated tau 217 (pTau217) levels in the subject during treatment. The method may further include continuing AR1001 treatment if the subject's plasma pTau181 or pTau217 levels decrease during treatment. The subject may have mild cognitive impairment due to Alzheimer's disease or mild Alzheimer's disease dementia. The method may also include assessing the subject's cognitive function using one or more standardized tests during treatment. AR1001 may be administered in a pharmaceutical composition in the form of a tablet or capsule.
Resumen de: WO2024261329A1
The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt and/or solvate thereof, wherein Y1 is a 9- or 10-membered bicyclic heteroaryl, Y2 is a 5- or 6-membered heteroaryl or 6-membered aryl, L is a linker, Z1' is selected from -NR23' R24' and -(C3-C7) heterocyclo alkyl comprising at least one nitrogen atom, and R23' and R24' may be various groups. The present invention further relates to a compound of formula (I) as HDAC6 inhibitor, typically for use in the treatment and/or the prevention of an HDAC6-associated disease, such as cancers, neurodegenerative diseases, neuropathies, cardiovascular diseases, or metabolic or hormonal disorders.
Resumen de: CN121930187A
The invention discloses a phenyl thiazole derivative as well as a preparation method and application thereof, and belongs to the field of medicinal chemistry. The structure of the phenylthiazole derivative is shown as a formula (I) or a formula (II). The phenyl thiazole derivative has antioxidant activity and has a good inhibition effect on A beta 42, part of the compounds have strong inhibition activity on tyrosinase, and the compounds or the pharmaceutical composition containing the compounds can be used for preparing drugs for preventing or treating neurodegenerative diseases, especially Alzheimer's disease, and can be used for preparing drugs for preventing or treating neurodegenerative diseases, especially Alzheimer's disease. The invention also discloses application of a whitening or anti-oxidation product.
Resumen de: CN121930307A
The invention discloses a sponge cyclic peptide compound and cyclic dipeptide, which comprise two amino acid fragments, namely proline and methionine sulfoxide, and provides application of the sponge cyclic peptide compound in an anti-Parkinson medicine, and the sponge cyclic peptide compound can obviously improve the movement speed of lesion zebrafish. Compared with the prior art, the invention has the advantages that a new compound is provided for developing and researching an anti-Parkinson medicine, and separation, synthesis and application of the active sponge cyclic peptide compound are provided.
Resumen de: CN121927019A
The invention belongs to the technical field of traditional Chinese medicine preparations, and particularly relates to a traditional Chinese medicine composition for treating salivation of Parkinson's disease as well as a preparation method and application of the traditional Chinese medicine composition. The traditional Chinese medicine composition comprises the following raw materials: rhizoma pinellinae praeparata, trichosanthes kirilowii maxim, coptis chinensis, fructus evodiae, fructus aurantii immaturus, inula flower, rhizoma zingiberis, vinegar schisandra chinensis and cuttlebone. According to the traditional Chinese medicine composition for treating the salivation of the Parkinson's disease, the nine medicinal materials are scientifically matched, all the medicinal materials perform respective functions and have a synergistic effect, single-prescription accurate treatment is achieved for the salivation symptom of the Parkinson's disease, and the salivation improvement effect is remarkable; meanwhile, the whole formula follows the compatibility principle of regulating cold and heat, toxic drugs are not used, the overall drug property is mild, the adverse reaction of gastrointestinal tracts easily caused when Parkinson's disease is treated by clinical Chinese and western medicines can be effectively reduced while the salivary treatment effect is achieved, the curative effect and the medication safety are considered, and the long-term medication requirement of Parkinson's
Resumen de: CN121930316A
The invention provides a plant-derived active polypeptide and application thereof in prevention or treatment of Parkinson's syndrome, and belongs to the technical field of polypeptide bioengineering. The amino acid sequence of the active polypeptide is MKGASSIMYALG, and the active polypeptide is prepared from Fuding white tea raw materials through a directional two-step enzymolysis process. According to the polypeptide, the damage of 6-OHDA induced BZ555 nematode dopaminergic neurons can be remarkably reduced, and the dyskinesia of Parkinson's syndrome model animals can be remarkably improved; meanwhile, the expression level of proinflammatory factors such as IL-1beta and IL-18 in serum of a model mouse can be lowered, the content of dopamine in a nigra area of brain tissue of the model mouse can be increased, and the activity of monoamine oxidase B can be reduced. The results show that the Fuding white tea-derived active polypeptide has exact prevention and treatment effects on Parkinson's syndrome, and has important development value and wide application prospects in the field of medicines.
Resumen de: CN121930997A
The invention discloses application of pseudomonas in treatment and/or prevention of Alzheimer's disease, and belongs to the technical field of microorganisms. The invention provides pseudomonas salmonella E14-1 for treating and/or preventing Alzheimer's disease, and the pseudomonas salmonella E14-1 can improve the autophagy level of nematodes and the unfolded protein reaction of endoplasmic reticulum, can reduce the latency period of AD mouse water maze, and can increase the number of platform crossing times. The invention further provides a composition for treating and/or preventing the Alzheimer's disease, a microbial agent and application. The composition and the microbial agent can effectively relieve the symptoms of the Alzheimer's disease.
Resumen de: CN121941500A
The present disclosure provides, among other things, a variety of techniques, including chirally controlled oligonucleotide compositions, and techniques for making and using such oligonucleotide compositions. In some embodiments, the present disclosure provides techniques useful for allele-specific knock-down of a mutant Huntingtin transcript. In some embodiments, the present disclosure provides techniques useful for reducing the expression, level, amount, and/or activity of a mutant Huntingtin transcript or product thereof. In some embodiments, the present disclosure provides methods for treating Huntington's disease.
Nº publicación: CN121930235A 28/04/2026
Solicitante:
CHANGCHUN GENESCIENCE PHARMACEUTICALS CO LTD
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Resumen de: CN121930235A
The invention relates to a compound as shown in a formula (I), a stereoisomer, a tautomer, an isotope label, nitrogen oxide, a solvate, a polymorphic substance, pharmaceutically acceptable salt or prodrug of the compound, a preparation method of the compound, and a pharmaceutical composition of the compound and the stereoisomer, the tautomer, the isotope label, the nitrogen oxide, the solvate, the polymorphic substance and the pharmaceutically acceptable salt or prodrug. In particular, the compounds are NK-3 receptor antagonists, the compound can be used for preventing and/or treating depression, anxiety disorder, psychosis, schizophrenia, psychotic disorder, bipolar disorder, cognitive disorder, Parkinson's disease, Alzheimer's disease, attention deficit hyperactivity disorder, pain, convulsion, obesity, inflammatory diseases, vomiting, pre-eclampsia, airway-related diseases, reproductive disorders, contraception and sex hormone dependent diseases, and can be used for preventing and/or treating diseases such as chronic bronchitis and chronic bronchitis. , gynecological diseases, and climacteric syndrome.
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