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170
resultados
Última actualización
25/11/2025 [07:07:00]
Resumen de: CN120983700A
本发明属于医学制药领域，具体提供一种血糖响应型水凝胶，所述血糖响应型水凝胶通过3D打印和同步光固化法形成，且由A层和B层交替层叠形成；所述A层包括生物墨水、抗炎组分和葡萄糖氧化酶，所述B层包括生物墨水和过氧化氢酶；所述生物墨水包括甲基丙烯酰化壳聚糖、用于光固化的光引发剂和用于增强力学性能的羟基磷灰石，所述抗炎组分选自银离子、抗生素和白细胞介素抗体中的一种或多种。本发明使用葡萄糖氧化酶和过氧化氢酶，二者联合配合使用，通过3D打印和分层载酶方法搭载在水凝胶上，对血糖的敏感性更好。本发明提供的血糖响应型水凝胶CH/IL‑17Abs@GOx/CAT具备优异的葡萄糖响应性与细胞相容性。
Resumen de: CN120987636A
本发明公开了一种光固化制备透光渐变多色氧化锆材料制备方法，制备改性氧化铝，所述改性氧化铝为氧化铝表面附着锶元素和铬元素；通过所述锆铝粉料制备底层料浆、中间层料浆、上层料浆；所述底层料浆包括锆铝粉料、着色剂；所述中间层料浆包括锆铝粉料、透光助剂、着色剂；所述上层料浆包括锆铝粉料、透光助剂、着色剂；通过光固化料浆通过3D打印，用底层料浆制备底层坯体，用中间层料浆在底层坯体表面制备中间层坯体，用上层料浆在中间层坯体表面制备上层坯体，从而得到氧化锆材料坯体；实现通过3D打印直接制备透光渐变、颜色渐变的透光渐变多色氧化锆材料，实现透光渐变多色氧化锆材料更接近真实牙齿颜色，且强度与韧性不降低。
Resumen de: CN120983168A
本发明提供了一种制造牙科物体的方法、制造物体的系统以及方法，制造牙科物体的方法，牙科物体包括基托和牙齿，方法包括：获取牙科物体的初始数据模型；沿至少一个方向，使牙科物体的初始数据模型的厚度增加预定值以获得目标数据模型；基于目标数据模型，一体制造目标物体，其中目标物体包括基托部分和牙齿部分，基托部分包括第一材料，牙齿部分包括不同于第一材料的第二材料；对目标物体进行处理，以沿至少一个方向减少目标物体预定值的厚度，从而获得牙科物体。本申请的技术方案有效地解决了相关技术中的需要人工粘结和打磨进而增加了生产成本的问题。
Resumen de: CN120983131A
本发明涉及骨科手术器械领域，尤其涉及一种用于经皮跟骨置钉术的3D打印跟骨置钉导板及其制备方法，包括：板体和引导部；其中，板体具有内表面和与内表面相对设置的外表面，板体的内表面为与足跟表面轮廓相适配的贴合曲面；引导部固定地设置于板体的外表面上，且引导部位于板体的外表面的中部区域；引导部包括固定地设置于板体外表面上的若干置钉导柱、以及沿置钉导柱中轴线开设的置钉孔；置钉孔贯穿板体；本发明的3D打印跟骨置钉导板通过基于患者个体解剖特征的设计和3D打印制造，实现了经皮跟骨置钉术的精准引导，有效解决了传统经皮手术依赖术者经验导致的精准度不足问题。
Resumen de: US2024376039A1
The present disclosure provides monomer compounds that can produce desirable polymeric materials and photo-curable resins. Further provided herein are methods of producing compounds, compositions, resins, devices, and polymeric materials. Also provided herein are methods of using compounds, resins, and polymeric materials for the fabrication (e.g., via 3D printing) of medical devices, such as orthodontic appliances.
Resumen de: CN120983699A
本发明属于生物材料与组织工程技术领域，具体涉及一种拓扑机械异质结构水凝胶支架及其一体化3D打印制备方法和应用。本发明提供的拓扑机械异质结构水凝胶支架，是一种拓扑结构的一体化3D水凝胶支架，结构包括纳米多孔软骨层和分级多孔骨层，纳米孔层和分级大孔层孔隙协同，兼具梯度力学性能、连续孔隙结构和生物活性可控三重功能，解决了骨软骨修复中的分层、力学失效及机制不明问题。本发明还提供了上述方案所述拓扑机械异质结构水凝胶支架的一体化3D打印制备方法。本发明提供的制备方法步骤简单，操作方便，可行性高。
Resumen de: US2025346703A1
The present disclosure provides micelles comprising a plurality of block co-polymers, the micelle comprising (i) a core comprising at least a portion of a poly(alkyl acrylate) block of one or more of the block co-polymers; and (ii) an outer layer comprising at least a portion of a poly(aryl acrylate) block or a poly(aryl methacrylate) block of one or more of the block co-polymers. The present disclosure also includes polymer compositions, polymer films, and devices (e.g., orthodontic equipment) including the same. Methods for making and using micelles, polymer compositions, polymer films, and devices (e.g., orthodontic equipment) are also disclosed. Further provided herein are methods of producing polymer compositions and using the same for the fabrication (e.g., via 3D printing) of medical devices, such as orthodontic appliances.
Resumen de: WO2025240824A2
Systems and methods for designing and generating architectures for the selective transport across fluid networks in 3D printed organ systems are provided. An example method includes: identifying, two or more fluid networks of a reference organ system and a transport characteristic between the two or more fluid networks; generating a model of each fluid network that includes channel parameters for channels associated with the fluid network; determining, based on the transport characteristic, a wall thickness between a channel of one fluid network, to a channel of another fluid network, for each of the two or more fluid networks; integrating the models of each fluid network to generate an organ system model that includes at least a representation of the functional region based on the wall thicknesses between respective channels between the two or more fluid networks; and generating a 3D printed organ system based on the organ system model.
Resumen de: WO2025236022A1
The invention relates to a method for producing an orthosis (21), characterised by the steps of: - providing a multi-axis 3D printer for printing a continuous fibre (30), - printing a first support section (22) of the orthosis (21), wherein the continuous fibre (30) is printed in curved areas (F1, F2) and/or flat areas arranged at an angle to one another other. The invention further relates to an orthosis produced by said method and to a computer-implemented method for determining control commands for a 3D printer for the 3D printing of said orthosis.
Resumen de: WO2025237975A1
The present invention refers to a process for preparing a three-dimensional tumor model having a core-shell structure using bioprinting techniques leading to tumor models capable of better reproducing the physiopathological complexity of real tumors, mimicking the tumor microenvironment and the original tumor tissue extracellular matrix. The process is based on the use of dECM (decellularized extracellular matrix) bioinks but with the particularity that no exogenous biopolymers that modify the rheological properties to improve printability are needed. The absence of rheological modifiers in the bioinks avoids any kind of physical or biochemical interference in the tumor model so obtained.
Resumen de: US2025352382A1
A customizable fitted device for immobilizing injuries and a method for constructing the fitted device is provided. The fitted device can be used to stabilize an arm, wrist, hand, leg, knee, ankle, foot or other body parts through custom formation. The device can be formed by a sidewall having one or more sidewall sections that can be secured together using retaining clips positioned within retaining clip slots on the device. The device can further include one or more openings defined in the sidewall of each device section while maintaining rigidity in the sidewall. The device can be constructed by of creating a 3D image scan of the particular body part on which the device will be applied, creating a design of the device to precisely match the contours of the 3D image scan, and using a 3D printer to construct the device according to the design.
Resumen de: WO2025239593A1
A method for designing a patient-customized implant for a bone defect site comprises the steps of: extracting, by a processor, a 3D image of a bone defect site; designing a 3D shape-based implant on the basis of the extracted 3D image of the bone defect site; calculating the direction and magnitude of partial loads received when the designed 3D shape-based implant is inserted into the bone defect site; designing, on the basis of the direction and magnitude of the partial loads, porosity of the designed 3D shape-based implant, the shape of solid metal, and the degree of porosity; and displaying, to a user, the designed 3D shape-based implant on the basis of the determined porosity, shape of solid metal, and degree of porosity.
Resumen de: US2025353632A1
A system for dispensing and verifying a dosage in a bottle. The system includes a stage for holding the bottle. The system further includes a pump-printer module, configured to receive a set of dosage specifications. The module includes a dosage dispenser configured to fill the bottle with the dosage according to the set of dosage specifications, and a printer device configured to print and apply a label onto the bottle listing out the set of dosage specifications. The dosage dispenser and the printer device are configured to operate simultaneously. The system further includes one or more imaging components disposed optically in-line with the stage, configured to capture a plurality of images of the bottle and the label.
Resumen de: WO2025238634A1
A system for performing substrateless and/or local donor Laser Induced Forward Transfer (LIFT), comprising a reservoir comprising at least one opening and an energy source configured to deliver energy to a donor material within said reservoir, characterized by at least one of: said reservoir is embedded into a medical device; said reservoir is in fluid connection with a medical device; said reservoir is incorporated into a medical device; said reservoir contains at least one biologically active substance; and, said reservoir is in fluid connection with at least one source of at least one biologically active substance. This system enables deposition of material by LIFT without any need for a donor substrate. Methods of substrateless and local donor LIFT, in particular for medical and biological applications, are also disclosed.
Resumen de: WO2025238558A1
Disclosed is a system and method for providing solutions for differentiating medications for blind and visually impaired patients. Applicant provides for a method of medication management that enables a user to differentiate solid and semi-solid dose forms using non-visual sense, namely tactical. By configuring a top, bottom, edge or side of said device to have one or more raised or indented letters, symbols, figures, logos, geometric figures, markings or textural differences, or any combination thereof, or in any variable shape and size thereof, to induce a tactile sensation, the system and method disclosed herein provide for on-dose tactile features that can improve the ability of patients to tell medications apart by touch and can be scaled into tablet manufacturing.
Resumen de: US2025352364A1
Disclosed are a metal inner core, a placeholder and a preparation method for a hip joint bone cement placeholder. By designing the metal inner core including a frame body and a supporting portion inside the hip joint bone cement placeholder, the strength of the placeholder is enhanced; due to the fact that the metal inner core is hollow, the antibiotic bone cement can fill the inner portion of the metal inner core, the content of antibiotics in the placeholder cannot be affected, and infection is effectively controlled; the hollowed-out structure endows the placeholder with lighter weight and stronger structural strength, and meanwhile, the material cost is effectively reduced; and according to the preparation method of the hip joint bone cement placeholder, the size design of the placeholder and the metal inner core is carried out, so that the joint matching degree between the placeholder and the patient is high.
Resumen de: US2025352320A1
Disclosed is a gynecological prosthetic including a plurality of anchor members configured to rest on anchor points within a vagina, and a plurality of connecting links that couple the anchor members together. The connecting links are configured to be compressible to enable a compact state when the gynecological prosthetic is being installed in the vagina. Also, the connecting links are configured to be expandable from the compact state after the gynecological prosthetic is installed in the vagina so as to push the anchor members outward against inside surfaces of the vagina to resist displacement of the gynecological prosthetic. This gynecological prosthetic can have a better fit to an anatomical shape of an upper vagina compared to current gynecological prosthetics, in part because its design and flexibility enable it to expand in certain directions. Also disclosed is a method and apparatus for custom-designing the gynecological prosthetic.
Resumen de: WO2025239483A1
The present invention relates to an apparatus and a method for manufacturing a customized 3D-printed upper-jaw fixation device. The apparatus for manufacturing a customized 3D-printed upper-jaw fixation device according to an embodiment of the present invention may comprise: a scanning unit for collecting a digital impression of an oral cavity through an intraoral scanner; a design unit for setting an engagement of a clasp by considering positions of teeth and a buccal surface in the digital impression; an output setting unit for setting a thickness and applying an offset to the digital impression in which the clasp engagement is set so as to generate an output file; and a printing unit for outputting the upper-jaw fixation device on the basis of the output file.
Resumen de: EP4650437A1
The present invention refers to a process for preparing a three-dimensional tumor model having a core-shell structure using bioprinting techniques leading to tumor models capable of better reproducing the physiopathological complexity of real tumors, mimicking the tumor microenvironment and the original tumor tissue extracellular matrix. The process is based on the use of dECM (decellularized extracellular matrix) bioinks but with the particularity that no exogenous biopolymers that modify the rheological properties to improve printability are needed. The absence of rheological modifiers in the bioinks avoids any kind of physical or biochemical interference in the tumor model so obtained.
Resumen de: US2024227300A1
Methods and systems for generating support structures for additively manufactured objects are described herein. In some embodiments, a method includes receiving a digital representation of a dental appliance configured to implement a treatment stage of a treatment plan for a patient's teeth. The method can include generating a support structure arrangement configured to support the dental appliance during an additive manufacturing process. The support structure arrangement can be generated using a machine learning model. The machine learning model can be trained on a training data set including appliance data representing geometries of a plurality of dental appliances, support structure data representing geometries of a plurality of support structure arrangements, and outcome data representing outcomes of the additive manufacturing process for the plurality of dental appliances with the respective support structure arrangements.
Resumen de: WO2024150259A1
Method for producing a biomimetic model of fibrosis which comprises the steps of: associating at least one cell type with at least one bio-ink containing collagen, obtaining a first compound; depositing said first compound in a culture medium obtaining a first deposited compound; keeping said first deposited compound in said culture medium for a period of time longer than 1 day, preferably comprised between 2 and 5 days; adding a profibrotic factor TGF-beta (TGFP) to said first deposited compound, obtaining a second added compound; keeping said second added compound in said culture medium for an additional period of time longer than 1 day, preferably comprised between 2 and 7 days; a biomimetic model of fibrosis which comprises at least one cell type associated with at least one bio-ink containing type I collagen and at least one profibrotic factor TGFβ is added to said bio-ink.
Resumen de: AU2025230762A1
Abstract The invention relates to a threaded bone implant, comprising: an elongate body extending from a proximal end of the bone implant to a distal end of the bone implant, the elongate body including an inner shank, one or more threads, each of which extend radially from the inner shank and extend along at least a portion of a length of the elongate body, a porous network of interconnected struts extending radially from the inner shank and disposed and extending axially between the one or more threads, the inner shank, the one or more threads, and the porous network of interconnected struts being formed together with an additive manufacturing process such that the inner shank, the one or more threads, and the porous network of interconnected struts are integral, and wherein the porous network of interconnected struts has a greater surface area in a central region of the elongate body than in a distal region of the elongate body, wherein the central region includes a midpoint of the length of the elongate body. Abstract The invention relates to a threaded bone implant, comprising: an elongate body extending from a proximal end of the bone implant to a distal end of the bone implant, the elongate body including an inner shank, one or more threads, each of which extend radially from the inner shank and extend along at least a portion of a length of the elongate body, a porous network of interconnected struts extending radially from the inner shank and disposed and extending a
Resumen de: US2023076682A1
The present disclosure relates to a method and device for matching oral model data that can provide matching points to a user to match oral model data and computerized tomography (CT) data even for edentulous patients. In this way, convenience is increased and matched data can be effectively generated even for edentulous patients for whom matching has been difficult conventionally.
Resumen de: CN223555063U
本实用新型公开一种用于眼部疾病治疗的跨巩膜持续给药装置，包括圆弧体、翼型固定板和固定带；圆弧体的底面开设有凹槽；两翼型固定板对称设置在圆弧体的两侧；两翼型固定板分别纳入外直肌的肌腹下和下直肌的肌腹下；若干固定带固接在圆弧体的底面上，固定带与凹槽的内壁之间设有间隙，间隙用于存放药膜；两翼型固定板远离圆弧体的一端设有间隔，圆弧体和两翼型固定板整体呈C字形。本实用新型能良好贴合眼球、减少对眼球的压迫，从而不影响眼球自由转动，提高佩戴舒适感及药物生物利用度，减少药物成分外渗于角结膜面及筋膜组织，避免药物通过结膜血管及淋巴管进步血压循环，降低全身副作用的风险，减少毒性及不良反应的发生。
Nº publicación: CN120959957A 18/11/2025
Solicitante:
中国人民解放军部队
Resumen de: CN120959957A
本发明属于医疗器械技术领域，涉及一种腰椎压缩性骨折俯卧过伸复位手术垫板的制备方法，包括以下步骤：收集患者胸腰椎影像学资料(X线片和CT图像)；通过三维重建软件生成腰椎三维立体模型；分析骨折椎体解剖学关系；利用Surgimap软件进行3D过伸位复位模拟，计算过伸角度(β‑α)，生成胸部垫子和髂部垫子的三维数字化模型；采用3D打印技术制作手术垫板，表面覆盖泡沫或硅胶软垫。本方法基于患者个性化数据，精准设计垫板参数，使腰椎稳定于过伸位，显著提高复位效果，降低手术难度和并发症。适用于PVP、PKP等手术，制作成本低，易推广，改善患者预后。
BOPI
Sede Electrónica
