Bioimpresión 3D

Manufacture of patient-specific orthodontic brackets with tooth-specific breakaway mechanism

Resumen de: GB2634831A

An orthodontic bracket 200 configured to be affixed to the tooth of a patient comprises at least one slot configured to receive an archwire, and a stress concentrator 202/203 on the face of the orthodontic bracket, wherein the stress concentrator is arranged along a line of the bracket and has a curve which matches the curvature of the tooth along the same line. A custom contoured polygon (201, Figure 3) may further be within a base of the orthodontic bracket, arranged along the same line and wherein at least part of the custom contoured polygon matches the shape of the tooth. A computer-implemented method of generating a 3D model of the bracket based at least in part on a 3D model of a patient’s tooth, and a system comprising at least one processor for doing the same are also claimed.

PHOTOCURABLE COMPOSITIONS AND METHODS FOR DELIVERING RADIATION TO A SUBJECT

Resumen de: AU2023293120A1

The disclosure is directed in part to polymerizable biocompatible or bioabsorbable compositions comprising styrene, N-vinylpyrrolidone or acrylate monomers, further comprising epoxide, urethane, polyether, or polyester oligomers and free radical initiators that can incorporate a radioactive source, including diagnostic or therapeutic radioisotopes and radioisotope precursors, to treat subjects with certain conditions, and methods of producing and use thereof.

PRODUCTION OF MICRONEEDLES FOR TRANSDERMAL DRUG DELIVERY BY DYNAMIC LIGHT PROCESSING

FDM PRINTED OBJECTS WITH HIGH-PERFORMANCE PHOTOCATALYTIC LAYERS

Resumen de: WO2023242179A1

The invention provides a method for producing a 3D item (1) by means of fused deposition modelling, the method comprising: a 3D printing stage comprising layer-wise depositing 3D printable material (201), to provide the 3D item (1) comprising 3D printed material (202), wherein the 3D item comprises layers (322) of 3D printed material, wherein the 3D printable material comprises a thermoplastic material (401) and a photocatalytic material (409) wherein during at least part of the 3D printing stage the method comprises producing pores (423) in the 3D printable material.

POLYOXAZOLIDONE DERIVATIVES AND THEIR USE IN MEDICAL DEVICES

Resumen de: EP4541837A1

The invention provides poly(hydroxy oxazolidone) compounds (PHOx) corresponding to following formula (I) or formula (II):whereinR_1', R_2', independently of one another each denote a C1 to C20 alkyl group, preferably a C1 to C10 alkyl group, more preferably a C1 to C3 alkyl group, most preferably a methyl group, and- R₃, R₄ independently of one another each denote hydrogen or a C1 to C20 alkyl group, preferably a C1 to C10 alkyl group, more preferably a C1 to C3 alkyl group, most preferably a methyl group, and- R₅, R_5', R₆, R_6', independently of one another each denote hydrogen or a C1 to C20 alkyl group, preferably a C1 to C10 alkyl group, more preferably a C1 to C3 alkyl group, most preferably a methyl group, or an aryl group, preferably a phenyl group, and- A is an organic linking group selected from a linear, branched, saturated, unsaturated, cyclic and/or non-cyclic aliphatic, aromatic or araliphatic hydrocarbon group, preferably having 1 to 20, more preferably 1 to 12, most preferably 1 to 8 carbon atoms and optionally further containing one or more functional groups selected from ether, ester, amide, amine, carboxyl, sulfur, halogen and/or urethane, and- Optionally A, R₃ and R₄ in formula (I) are linked to each other to form a cyclic structure,

3D PRINTING MOUTH PIECE INCLUDING SIMULATION OF DEFORMATION

Resumen de: WO2023242411A1

A method for manufacturing a mouth piece, in particular by jetting droplets of a first droplet material and a second droplet material in a 3D printing process. The method comprises a step of obtaining dental data of a user and an input mouth piece model. A simulation is carried out to determine a deformation of the input mouth piece model in response to an exerted force. Based on the deformation, the input mouth piece model is adapted to a work mouth piece model by substituting material of at least a portion of the input mouthpiece model by a replacement material. Finally, the mouth piece is manufactured based on the optimised work mouth piece model.

SYSTEM, METHOD AND APPARATUS FOR PERSONALIZED DENTAL PROSTHESES PLANNING

Resumen de: WO2023240333A1

Methods, systems, and techniques for collecting data for use in designing a personalized dental prosthesis for a patient. At least one camera is used to obtain a series of two- dimensional photos or a three-dimensional model of a head and face of the patient. At least one machine learning model is used to determine facial or oral landmarks and a central incisal edge of the prosthesis from the photos or model. Dimensions for the dental prosthesis are determined form the landmarks and central incisal edge. The dimensions include a labial border of the prosthesis, distal borders of the prosthesis, a superior border of the prosthesis, an inferior border of the prosthesis, a lingual border of the prosthesis, and buccal borders of the prosthesis. The dimensions are output to an output file for use in manufacturing the prosthesis.

一种3D打印个性化组配式支撑假体

Resumen de: CN222777392U

本实用新型公开了一种3D打印个性化组配式支撑假体，涉及医用假体技术领域。该3D打印个性化组配式支撑假体包括第一支撑体和第二支撑体，其中，第一支撑体由3D打印而成，设置有第一装配面；第二支撑体由3D打印而成，设置有第二装配面；第一装配面和第二装配面的形状轮廓匹配，第一支撑体和第二支撑体通过第一装配面和第二装配面抵接至一起，且第一支撑体和第二支撑体装配至一起后的外轮廓与骨缺损区域的轮廓匹配。本实用新型提供的3D打印个性化组配式支撑假体能够与骨缺损的轮廓较为精确的匹配，并且在安装过程中更加便捷。

一种3D打印镂空外固定支具及其制备方法

Resumen de: CN119857016A

本发明提供一种3D打印镂空外固定支具及其制备方法，属于医疗器械技术领域，包含支具本体，所述支具本体上预留着上药口，所述上药口中安设着支具块，所述支柱与支具本体间经由衔接件相连；所述衔接件包含包含衔接片、上衔接模块与下衔接模块；所述上衔接模块安设在衔接片上，所述上衔接模块包含内柱、外壳与止位单元，所述内柱安设在外壳中，所述内柱中安设着止位单元；所述下衔接模块安设在支具本体上，所述下衔接模块包含下衔接筒、衔接套与牵引单元，所述下衔接筒安设在支具本体的外壁面上。本发明解决了目前采用损伤性的外固定支架进行固定，易造成感染、活动不便、肌肉萎缩，同时患者体验较差，并且存在一定的医疗风险的问题。

一种咬合重建中后牙诊断饰面及其数字化制备方法

Resumen de: CN119837652A

本发明提供了一种咬合重建中后牙诊断饰面及其数字化制备方法，该方法包括：获取全牙列扫描数据；基于戴用��垫适应后的咬合高度，设计后牙蜡型，得到后牙咬合面数据OCCLU1；将后牙咬合面数据OCCLU1进行间断分割，间断删除部分后牙咬合数据，得到后牙咬合数据OCCLU2；分别基于全牙位蜡型模型和间断牙位蜡型模型进行3D打印；基于3D打印模型，制作成型阴模INDEX1及成型阴模INDEX2；利用成型阴模INDEX2对部分待修复后牙进行注射成型；利用成型阴模INDEX1对剩余待修复后牙进行注射成型。本方案实现了后牙诊断饰面的快速、高精度成型，且制作的诊断饰面具有良好的稳定性和耐用性。

一种多尺度分级镁合金支架及其制备方法和应用

Resumen de: CN119838055A

本发明属于生物医用材料技术领域，公开了一种多尺度分级镁合金支架及其制备方法和应用。本发明以镁合金为基材，采用激光粉末床熔融技术，得到基体支架；将基体支架进行化学抛光，然后进行高温氧化处理，在表面形成氧化层，再进行水热反应，在表面形成水滑石层，得到多尺度分级镁合金支架。利用L‑PBF技术实现支架宏观结构的精准控制，通过结构设计实现支架介观孔隙的优化设计，支架表面的氧化层和水滑石层形成的微米级涂层可抑制快速降解，水滑石纳米片可提升表面粗糙度和亲水性，有利于成骨细胞的附着和分化。本发明支架的多尺度设计(宏观形状、介观孔隙、微观涂层、纳米表面)有效模仿了天然骨的层次结构，提升了支架的生物适应性。

医療監視装置の印刷機構及び医療監視装置

Resumen de: WO2023169846A1

The present invention provides a printing mechanism for a medical monitoring device and a medical monitoring device. The printing mechanism comprises a movable frame assembly comprising a frame and a print paper drawer for holding the print papers, the print paper drawer being mounted on the frame to move along with the movable frame assembly, wherein a front end wall of the print paper drawer is formed as a curved wall comprising a first portion extending perpendicularly from a front end of a bottom plate of the print paper drawer and a second portion extending from the first portion and bending towards a rear end of the print paper drawer with respect to the first portion, and the second portion forms an anti-tilting surface for preventing the print papers from tilting. According to the printing mechanism for the medical monitoring device of the present invention, the end of the print papers contacting the anti-tilting surface does not slip and tilt during printing while the smoothness in feeding the print paper to the printing head is not affected.

一种3D打印多孔复合支架的制备方法及应用

Resumen de: CN119838059A

本发明属生物医用材料领域，具体公开了一种3D打印多孔复合支架的制备方法及应用。将I型胶原和丝素蛋白复合凝胶修饰在聚多巴胺涂层的3D打印三元素掺杂羟基磷灰石/聚己内酯(PCL)复合支架上，所述三元素掺杂羟基磷灰石使用化学沉淀法合成，晶格内掺杂有Mg2+、Sr2+和SeO32‑离子。本发明的提供的3D打印多孔复合支架有效地模拟天然骨软硬结合的结构与功能，有助于调控干细胞命运来改善骨再生进程，在消除肿瘤的同时修复骨缺损，可应用于骨缺损修复或骨肉瘤治疗。

用于正畸器具的转移设备和相关的制造方法

Resumen de: US2024238069A1

A method of making a transfer apparatus includes providing a physical mockup having a shape that corresponds to a positive shape of a patient's dental arch and one or more carrier assemblies that each include a crane body releasably connected to an orthodontic appliance. A transfer apparatus may be formed over the physical mockup, with the transfer tray representing a negative replica of at least a portion of the mockup. The transfer apparatus may be used to seat the appliance on a patient's dental arch, after which point the appliance can be separated from the crane body and bonded to the associated tooth.

一种3D打印多孔复合支架的制备方法及应用

Resumen de: CN119838058A

本发明属生物医用材料领域，具体公开了一种3D打印多孔复合支架的制备方法及应用。将含生长因子的I型胶原和丝素蛋白复合凝胶修饰在聚多巴胺涂层的3D打印三元素掺杂羟基磷灰石/聚己内酯(PCL)复合支架上，所述三元素掺杂羟基磷灰石使用化学沉淀法合成，晶格内掺杂有Zn2+、Sr2+和SeO32‑离子。本发明的提供的3D打印多孔复合支架有效地模拟天然骨软硬结合的结构与功能，有助于调控干细胞命运来改善骨再生进程，在消除肿瘤的同时修复骨缺损，可应用于骨缺损修复或骨肉瘤治疗。

磁驱动多模态电子导管及其制备方法

Resumen de: CN119837496A

本发明公开了一种磁驱动多模态电子导管及其制备方法。该磁驱动多模态电子导管包括：多通道铁磁导管、位于所述多通道铁磁导管一端的若干多参数微电极；所述多通道铁磁导管用于所述磁驱动多模态电子导管的磁驱动导航和导电，所述多参数微电极插入所述液态金属通道中，所述多参数微电极用于生化检测；所述多通道铁磁导管包括磁响应基体外鞘、空心通道和若干液态金属通道；所述空心通道和若干所述液态金属通道嵌入至所述磁响应基体外鞘中；所述磁响应基体外鞘的材料包括：由热塑性柔性聚合物和磁性颗粒按照预设比例得到的复合材料。本申请中有利于降低检测复杂度，提升检测准确度。本发明可广泛应用于生理参数检测技术领域内。

METHOD FOR DESIGNING ORTHODONTIC DEVICE ACCORDING TO PARTIAL DESIGNATION OF TEETH

Resumen de: WO2025079951A1

The present invention relates to a method for designing, using a computer, an orthodontic device on the basis of partial designation of teeth, the method being characterized by comprising the steps of: displaying the arrangement of teeth of a patient (S01); setting up and displaying all the teeth in the arrangement of teeth in the state after orthodontics (S02); designating teeth in the teeth arrangement (S03); designating specific portions in the designated teeth (S04); and inputting the thickness of the orthodontic device in contact with the specific designated portions in the designated teeth (S05).

Microscope Enabled 3D Bioprinting System

Resumen de: US2025123476A1

An apparatus controls a series of actuators mounted onto inverted microscope assemblies to add 3D bioprinting and pick and place capabilities on a microscopic scale. One or more syringes are also mounted to the apparatus and the plunger of each syringe is independently actuated to extrude or extract fluids from the optically aligned needle. A software package communicates with the microscope x, y stage as well as the on-board motor controller which actuates the syringes and needle to set the x, y, z position and syringe in real time.

弾性歯列矯正器具

Resumen de: CN112055571A

Provided herein is an orthodontic aligning appliance for moving tooth or teeth of a patient and methods of making and using the same. The orthodontic aligning appliance is formed of a material ("appliance forming material") having an elastic material in an amount that imparts to the aligner elastic properties such that the appliance exerts a continuous aligning force on a tooth or teeth, the elastic material is a material other than polyester, and the elastic material accounts for all or substantially all the elastic properties of the appliance.

TRANSCATHETER DELIVERABLE PROSTHETIC HEART VALVES AND METHODS OF DELIVERY

Resumen de: AU2025202301A1

A prosthetic valve includes a frame and a flow control component. The frame has an aperture extending through the frame about a central axis. The flow control component is mounted within the aperture and is configured to permit blood flow in a first direction approximately parallel to the vertical axis from an inflow end to an outflow end of the flow control component and to block blood flow in a second direction, opposite the first direction. The frame has an expanded configuration with a first height along the central axis, a first lateral width along a lateral axis perpendicular to the central axis, and a first longitudinal length along a longitudinal axis perpendicular to the central axis and the lateral axis. The frame has a compressed configuration with a second height less than the first height and a second lateral width less than the first lateral width.

SYSTEMS AND METHODS FOR GENERATING PATIENT-SPECIFIC IMPLANTS FOR ANATOMICAL STRUCTURES OF PATIENTS

Resumen de: US2025120816A1

Embodiments for generating patient-specific implants for anatomical structures of patients are disclosed. One embodiment includes a method that includes receiving image data of an anatomical structure of a patient, where the image data indicates a fracture site associated with the anatomical structure; receiving manipulation data associated with manipulation of one or more parameters associated with the fracture site in a virtual reality environment; visualizing a three-dimensional (3D) model of the anatomical structure based on the image data, the one or more parameters, and the manipulation data, where the 3D model is visualized in a 3D space; generating a set of instructions for a printer based on the 3D model, and controlling the printer for generating a 3D printed model of the anatomical structure based on the set of instructions. The 3D printed model is configured to receive an implant, such that the implant is contoured to match the fracture site.

３Ｄプリント医薬品の調製プロセス

Resumen de: CN119212681A

The invention relates to a method for producing a 3-D printed pharmaceutical product.

骨補填材の製造方法

Resumen de: JP2025063999A

【課題】骨欠損部に応じた形状等、所定形状の骨補填材を安価に製造可能な骨補填材の製造方法を提供する。【解決手段】骨補填材の製造方法は、β－リン酸三カルシウムを主成分とする骨補填材の製造方法である。骨補填材の製造方法は、リン酸一水素カルシウム二水和物、水酸化カルシウム及び光硬化性樹脂組成物を含む光硬化３Ｄプリント用スラリーを用い、光造形３Ｄプリンターで所定の形状に造形する造形工程と、造形された造形体を焼成する工程と、を含む。【選択図】図２

押し潰し可能なチューブ状ダイアフラムを有する医療手順用イントロデューサシースバルブ

Resumen de: JP2023155490A

To provide improved introducer sheath valves for use in endovascular, laparoscopic and other surgical procedures.SOLUTION: The invention relates to a valve used in medical procedures. More specifically, the invention relates to an introducer sheath valve used in minimally invasive and conventional surgical procedures. The valve may accommodate a wide range of surgical implement diameters, shapes and multiple implements without imposing the high frictional forces of known valves.SELECTED DRAWING: Figure 1

SPINAL INTERBODY FUSION DEVICE

Nº publicación: US2025120822A1 17/04/2025

Solicitante:

SPINE WAVE INC [US]
SPINE WAVE, INC

Resumen de: US2025120822A1

A bellows shaped spinal implant, comprising an upper plate, a lower plate and a bellows shaped shell extending between and joining the upper and lower plates. The bellows shaped shell is formed of titanium or an alloy comprising titanium and includes a wall extending therearound that defines a hollow interior. The wall has a thickness in the range of 0.5 mm to 1.0 mm to provide for radiographic imaging through the wall. The wall is angled or curved inwardly or outwardly between the upper and lower plates to provide stiffness mimicking the stiffness properties of a similarly sized polyetheretherketone (PEEK) implant. The upper and lower plates each comprise porous contact regions including a three-dimensional gyroid lattice structure defined by a plurality of struts and pores in communication with the hollow interior. The outer surfaces of at least a portion of the struts may comprise a laser ablated textured surface.