Alerta

CONTACT LENSES INCLUDING MEDICAMENTS AND METHODS OF MAKING AND USING SAME INCLUDING SLOW RELEASE OF GLAUCOMA TREATING DRUGS AND COMFORT ENHANCING DRUGS

Resumen de: WO2024254134A2

The present invention recognizes that medical devices, such as but not limited to contact lenses, can be made having at least one coating layer provide drug storage and drug release tor the treatment of various diseases, disorders, or conditions, One aspect of the present invention includes a packaged medical device including a medicament. Another aspect of the present invention includes a drug delivery contact lens. A farther aspect of the present invention includes a. method of making a drug delivery contact lens. An additional aspect of the present invention includes a method of using a drug delivery contact lens. A further aspect of the present invention includes a medical device including bimatoprost and N-vinylpyrrolidone.

PATIENT SPECIFIC INSTRUMENTATION AUTOMATION PLATFORM

Resumen de: WO2024257100A2

The present invention, in some embodiments thereof, relates to a surgical guiding joint integration group (JIG) and, more particularly, but not exclusively, to a surgical guiding JIG for varus de rotation osteotomy (VDRO) procedure.

METHODS AND SYSTEMS FOR VAGINAL THERAPEUTIC DEVICE FITTING

Resumen de: EP4725409A2

0001 Pelvic organ prolapse (POP) and urinary incontinence (UI) are common, often distressing conditions, where, at present, physical non-surgical devices are fitted by best guess or trial-and-error with devices offered in a range of standard designs and sizes. However, each user is unique and accordingly methods, systems and devices providing a personal pelvic health characterization and provisioning approach are outlined that factor user specific anatomy and physiology, user lifestyle, user experiences and automated assessments into provisioning custom vaginal therapeutic devices. Further, user specific anatomy and physiology should be obtained in a reproducible manner with devices and systems that remove measurement artifacts, errors, bias etc. whilst providing the patient with an improved experience and the medical personnel with ergonomic, efficient, and easy to use systems exploiting combinations of dedicated multi-patient measurement equipment with user specific consumable items for cleanliness etc.

POWERED ORAL CARE IMPLEMENT INCLUDING A TRACKING MODULE AND TRACKING MODULE AND TRACKING MODULE THEREOF

Resumen de: EP4725359A2

0001 An oral care system that includes an oral care implement and a tracking attachment. The oral care implement may include a handle and a head. The tracking attachment is detachably coupled to the oral care implement. The tracking attachment may include a first component comprising a first housing having an inner surface that defines a first cavity and a second component comprising a second housing having an inner surface that defines a second cavity. When the tracking attachment is coupled to the oral care implement, a first portion of the handle is positioned within the first cavity and a second portion of the handle is positioned within the second cavity.

PRE-CONNECTED ANALYTE SENSORS

Resumen de: EP4725401A2

A system (101) for measuring an analyte concentration in a host comprises a transcutaneous analyte sensor (138); a bottom housing (522); a top housing (520); and sensor electronics (112) configured to connect to the transcutaneous analyte sensor (138). The sensor electronics (112) are configured to be disposed between the bottom housing (522) and the top housing (520). The bottom housing (522) includes a recess (726) with a floor (704), and the floor (704) includes a plurality of locating pins (784, 786), the plurality of locating pins (784, 786) extending upward from the floor (704). The plurality of locating pins (784, 786) are configured to extend into a plurality of holes (794, 796) in a substrate (404). A conductive member (762, 764) is configured to establish electrical connection between the sensor (138) and the sensor electronics (112).

CONFIGURABLE PHOTOPLETHYSMOGRAM SYSTEM

Resumen de: EP4725400A1

Methods, systems, and devices for optical signal measurement are described. A wearable electronic device may activate a first combination of optical sensors, the first combination of optical sensors including a set of transmitter sensors and a set of receiver sensors. In some cases, one or more optical sensor of the first combination of optical sensors may be positioned under a protrusion on an inner surface of the wearable electronic device. The device may measure, at the set of receiver sensors at a first time, one or more signals from the set of transmitter sensors, determine a signal quality metric associated with the one or more signals, and select a second combination of optical sensors for use at a second time based on the signal quality metric.

BIO-PRINTED SKIN MODEL, RELATED THREE-DIMENSIONAL PRINTING PROCESS AND DIRECT PERFUSION DEVICE PROVIDED WITH SAID MODEL

Resumen de: WO2024252292A1

The bio-printed skin model (1) comprises: - at least one dermal layer (2) comprising at least one polymer matrix and a mixture of fibroblasts and endothelial cells and configured to simulate a human dermal tissue; - at least one epidermal layer (3) comprising at least one mixture of keratinocytes and configured to simulate a human epidermal tissue; wherein the dermal layer (2) comprises at least one inner duct (4) formed by fibroblasts and endothelial cells, configured to simulate a vascular channel of human skin and provided with at least two end stretches communicating with the outside and connectable to a system for active perfusion of substances.

Method and system for confirmation of microneedle-based analyte-selective sensor insertion into viable tissue via electrical interrogation

Resumen de: US12599337B1

A system and method to confirm the insertion of an analyte-selective sensor comprising an array of microneedles possessing vertical extent between 200 and 2000 μm into viable tissue is disclosed herein. Mechanical insertion of an analyte-selective sensor is firstly attempted by means of an application of external force. Either during or following this routine, an electrical stimulus is applied between at least two distinct electrodes located within the said analyte-selective sensor; a resultant response is measured. This response is compared with a reference value to determine if insertion was successful. If insertion was successful, no further effort is required and the sensor can operate as intended. However, if insertion was not successful, the user can be instructed to continue to apply additional force to said sensor to achieve successful insertion or otherwise re-apply the said sensor altogether.

一种基于HAMA脂肪细胞微球与乳腺类器官的3D打印乳腺的方法

Resumen de: CN121845797A

本发明提供一种基于HAMA脂肪细胞微球与乳腺类器官的3D打印乳腺的方法，涉及生物医学技术领域，旨在解决现有技术中结构功能模拟不完整、细胞存活率低及分布不均等问题。核心技术方案包括：以HAMA脂肪细胞微球作为脂肪层功能单元，乳腺类器官作为腺体层单元，通过双喷嘴3D打印机实现双层结构的精准定位；通过调控HAMA交联度和微球孔隙率，提升脂肪细胞存活率；采用专用生物墨水和优化打印参数，使功能单元团聚率≤5%，并在界面设置交联过渡层促进结构连接；通过添加明胶和双重交联工艺，使模型压缩模量达10‑15kPa，降解周期3‑6个月，兼具良好力学性能和生物相容性。本申请有效地模拟乳腺生理微环境，在组织工程重建、药物筛选和疾病研究等领域具有重要应用价值。

一种具有压力感知及自适应调节功能的智能防压疮床垫

Resumen de: CN121845873A

本发明公开了一种具有压力感知及自适应调节功能的智能防压疮床垫，包括床垫本体、可控气囊阵列、弹性垫、柔性压力传感器阵列、床垫外套和智能控制系统。本发明的具有压力感知及自适应调节功能的智能防压疮床垫，采用主动预测与个性化智能调节，基于患者的个体差异和行为模式，建立个性化压力模型和动态压力平衡算法，实现压力的精准调节和提前预测，有效预防压疮的发生，降低压疮发生率。

METHOD APPARATUS AND COMPUTER PROGRAM FOR CALCULATING BIOLOGICAL EFFECTIVE DOSE

Resumen de: KR20260050188A

본 발명에 따른 방사선량 산출 방법은, 대상체에 대한 입력데이터 -상기 입력데이터는 상기 대상체에 대한 기능 영상 및 해부 영상을 포함함- 를 수신하는 입력 단계, 상기 입력데이터에 기초하여 물리적 방사선량을 산출하는 제1 산출 단계 및 상기 물리적 방사선량에 기초하여 생물학적 유효 방사선량을 산출하는 제2 산출 단계를 포함하고, 상기 제1 산출 단계 및 제2 산출 단계는, 몬테카를로 기법에 기초하여 생성된 학습데이터를 이용하여 학습된 신경망 모델에 의한 제1 방식에 기초하여 수행되거나, 소정 수식에 의한 제2 방식에 기초하여 수행된다. 본 발명에 따르면, 인체 등 대상체의 조직에 대한 방사선량을 빠르고 정확하게 산출할 수 있게 되고, 핵종 또는 방사선의 종류 등에 따른 생물학적 유효 방사선량을 높은 정확도로 산출할 수 있게 된다.

一种个性化阶梯式3D打印鼻矫形鼻腔支架及使用方法

Resumen de: CN121845825A

0001 本发明涉及鼻整形技术领域，具体为一种个性化阶梯式3D打印鼻矫形鼻腔支架及使用方法，包括用于支撑鼻翼的鼻腔支架，鼻腔支架的外表面固定连接有膨胀块，两个鼻腔支架通过连接块6连接，形成一个完整的支架。该个性化阶梯式3D打印鼻矫形鼻腔支架及使用方法，通过将患者原始鼻腔形态与正常鼻腔形态建立动态拟合，在过程中打印若干支架，鼻腔支架的数量根据患者的鼻畸形情况设置，形成双侧鼻畸形形阶梯式鼻矫形支架，患者在佩戴治疗时，通过将鼻腔支架从原始鼻腔形状向正常鼻腔形状渐变，可以有效减少患者佩戴支架时的不适感。

基于非侵入式脑机接口的睡眠质量监测与分析方法、装置、设备及存储介质

Resumen de: CN121845615A

0001 本申请公开了一种基于非侵入式脑机接口的睡眠质量监测与分析方法、装置、设备及存储介质，涉及脑电信号处理技术领域，所述方法包括：对原始脑电信号进行预处理，并从预处理后的信号中提取脑电特征频段信息，基于各频段的均值、标准差及功率占比构建多维特征向量，利用滑动窗口与随机森林模型划分深睡期、浅睡期和快速眼动期并计算其占比，再结合睡眠阶段连续序列计算睡眠稳定性参数，融合各睡眠阶段占比、稳定性参数和信号质量参数通过加权方式生成睡眠质量评分，最终根据评分、阶段占比和频段信息生成可视化报告与睡眠改善建议，完成睡眠质量的监测与分析。本申请能够兼顾睡眠质量监测与分析的高精度与易用性。

一种脊柱侧凸的智能矫正评估系统及方法

Resumen de: CN121845814A

本发明属于矫正智能控制技术领域，公开了一种脊柱侧凸的智能矫正评估系统及方法，基于智能多模块传感器，搭建脊柱侧凸智能矫正系统；基于人体三维表面形貌测量技术，建立脊柱侧凸智能评估系统；基于智能多模块传感器与可穿戴超声图像设备，评估脊柱矫正时脊柱相关肌肉的内部形态和活动特征；结合脊柱侧凸矫正策略与脊柱矫正效果和脊柱相关肌肉活动特征，综合分析脊柱侧凸矫正机制，确定最佳生物力学矫正策略。本发明对脊柱施加外力实现脊柱畸形的控制，通过对脊柱侧凸矫正机制分析，揭示不同矫正策略产生的矫正效果，有助于提高脊柱侧凸患者保守治疗疗效，对提高患者生活质量，降低家庭经济负担，减轻医疗体系压力具有重要意义。

METHOD FOR DESIGNING PATIENT-SPECIFIC MANDIBULAR GUIDANCE AND DEVICE OFFERING IMPLANT AND PATIENT-SPECIFIC MANDIBULAR GUIDANCE THEREOF

Resumen de: KR20260050323A

환자 맞춤형 하악 가이던스를 설계하는 장치에 있어서, 환자의 하악골 이미지를 입력받는 입력부; 상기 입력된 하악골 이미지를 기반으로 환자의 해부학적 구조를 분석하고, 상기 분석된 환자의 해부학적 구조를 기초로 하악골 절제 부위 및 나사 위치를 포함한 하악 가이던스를 3차원으로 모델링하는 프로세서; 및 상기 모델링된 하악 가이던스를 표시하는 출력부;를 포함하는, 환자 맞춤형 하악 가이던스를 설계하는 장치를 제공한다.

根据非对比计算机断层摄影的射血分数

Resumen de: EP4725423A1

0001 For segmentation (310) and/or ejection fraction determination (320), photon-counting detection (100) for CECT in ES is used to create (110) virtual NCCT for machine training (130). The lack of NCCT data at ES for training (130) segmentation is overcome by use of the virtual NCCT. Since the segmentation (310) is trained (130) on non-contrast imaging at ES, accurate ES segmentation (310) from NCCT may be provided. The EF may be calculated (320) using NCCT.

用于关节假体的锆基合金原位氧化涂层的制备方法、医用关节假体及应用

Resumen de: CN121852847A

本发明公开了用于关节假体的锆基合金原位氧化涂层的制备方法、医用关节假体及应用，该方法适用于电子束熔化（EBM）、选择性激光熔化（SLM）制备或锻造加工的锆基合金（含 Zr‑2.5Nb、Zr‑Nb‑Ti、Zr‑Mo‑Nb 等体系），通过反复创建氧浓度梯度促使氧原子向材料内部扩散，精确形成高氧扩散过渡层与ZrO₂基原位氧化陶瓷涂层，同时建立氧化温度（T）‑陶瓷涂层厚度（d）‑耐磨性（WR）的耦合数学模型，实现涂层性能与产品尺寸的双重精准调控。本发明制备的涂层与基体通过高氧扩散过渡层紧密结合，过渡层深度超越传统工艺 40% 以上，氧化后假体尺寸变化量≤±0.01mm；涂层表面硬度≥1053Hv，磨损率≤0.8×10⁻⁶mm³/(N・m)，显著提升锆基合金的耐磨性能与尺寸稳定性，解决了关节假体长期服役中磨损碎屑导致的无菌性松动及尺寸精度失控问题，适用于髋关节、膝关节等医用关节假体的规模化生产。

基于AI与3D打印的多孔钽牙种植体的制造方法

Resumen de: CN121845774A

本发明提供一种基于AI与3D打印的多孔钽牙种植体的制造方法，涉及口腔医学与3D打印技术领域，包括：S1、建立历史CBCT数据集；使用历史CBCT数据集在AI建模平台中基于深度学习算法进行训练构建口腔重建模型；S2、根据患者口腔的CBCT生成相应的口腔重建模型；种植体三维模型包括牙冠、牙基座和种植基体；种植基体具有梯度多孔结构，由上至下分为孔隙率和孔径逐渐降低的表层区、过渡区和核心区；S3、调节种植体三维模型的形状和尺寸，对种植体三维模型进行优化；S4、3D打印得到种植体；S5、在种植基体的外表面以及内部孔隙的内壁表面制备羟基磷灰石涂层。本发明解决了现有技术中存在的种植体弹性模量不匹配、骨整合效率低及修复体适配性差的问题。

一种基于热响应的自适应3D打印放疗压舌板及其使用方法

Resumen de: CN121846553A

本发明提供一种基于热响应的自适应3D打印放疗压舌板，压舌板为高硬度弹性支撑骨架与热塑形自适应层相结合的一体化成型复合结构，优选为邵氏硬度95A的热塑性聚氨酯制成的高硬度弹性支撑骨架和覆盖于骨架表面由聚己内酯制成的热塑形自适应层构成的双材料复合结构，采用多材料3D打印一体化成型，聚己内酯层在约70℃温水中可软化塑形，在常温或口腔温度下硬化定型；使用时，通过温水加热使自适应层软化，置于患者口腔内进行实时塑形，完美贴合牙齿、上颚及舌背的独特口腔结构，冷却后固定。本发明解决了传统压舌板个性化适配不足、无法适应分次治疗间组织变化的临床难题，实现了个性化贴合，显著提升了放疗摆位的精确性、重复性及患者舒适度。

一种基于无溶剂柠檬酸基的生物墨水及其制备方法、3D打印方法和应用

Resumen de: CN121851636A

本发明属于3D打印生物技术领域，具体涉及一种基于无溶剂柠檬酸基的生物墨水及其制备方法、3D打印方法和应用。包括以下步骤：将柠檬酸与含羧基、羟基、氨基或酸酐基团的化合物通过缩聚、酯交换或取代反应，制备得到柠檬酸基预聚物；将所述柠檬酸基预聚物与增稠剂复配制备得到适用于挤出式3D打印的柠檬酸基生物墨水。本发明基于挤出式3D打印的柠檬酸基生物墨水，为拓展柠檬酸基生物材料在组织工程中的应用提供了高效、精准的方法；通过调控柠檬酸基预聚物反应条件及增稠剂复配比例，优化柠檬酸基生物墨水的流变固化特性。

モジュール式エネルギーシステム

Resumen de: WO2022208280A1

A modular energy system is disclosed including a header module including an enclosure and a display including a coupler. The enclosure defines a recess. The recess includes a first guidewall and a second guidewall. The coupler is removably positionable in the recess. The coupler includes a first sidewall and a second sidewall. The first guidewall is configured to guide the first sidewall as the coupler moves through the recess. The second guidewall is configured to guide the second sidewall as the coupler moves through the recess.

双峰粒径分布的二硅酸锂玻璃陶瓷和修复体及制备方法

Resumen de: CN121850386A

本发明公开了一种双峰粒径分布的二硅酸锂玻璃陶瓷和修复体及制备方法；其中二硅酸锂玻璃陶瓷的制备方法包括配料、熔融、淬冷、破碎和回转热处理等步骤，通过对原料以及配合淬冷和回转热处理步骤进行具体设置，得到具体粒径范围的具有双峰粒径分布的球形二硅酸锂玻璃陶瓷粉体，能够制备高固含量，流变性能优良的打印浆料，通过对一步热处理法3D打印修复体制备方法进行具体设置，在具体粒径范围的具有双峰粒径分布的球形二硅酸锂玻璃陶瓷粉体作为原料的基础上，通过设置一步的热处理法，制备得到了具有较高美学特性的二硅酸锂玻璃陶瓷修复体。

3D打印技术在脊髓灰质炎患者行走辅助工具的应用

Resumen de: CN121847809A

本发明公开了基于3D打印人体外骨骼的方法，包括有以下步骤：S1、三维扫描人体外表形状；S2、对扫描的人体信息进行传输和三维搭建；S3、人体外骨骼的三维设计；S4、3D打印机进行人体外骨骼打印；S5、对3D打印出来的实体进行打磨；本发明通过三维扫描人体外表形状，对人体外骨骼进行三维模型建设，通过关节模型库对关节连接结构进行选择使用，更加的贴合人体关节弯曲度，并且通过辅助蹲起模块设计连接端点，便于对弹簧或者液压机构进行安装连接，并且在人体外骨骼进行三维模型扫描处理后，根据三维模型扫描的结果进行控制3D打印机运行，使得3D打印机能够完成对外骨骼的打印。

整形外科用膝プロテーゼの金属強化ポリマー大腿骨コンポーネント及びそれを作製する関連方法

Resumen de: US12569347B2

An orthopaedic knee prosthesis includes a femoral component having a metal base with a polymer articular layer molded thereto. A method for making a metal-reinforced femoral component of an orthopaedic knee prosthesis is also disclosed.

新規方法

Nº publicación: JP2026511666A 14/04/2026

Solicitante:

ナノデントエス．アール．エル．

Resumen de: WO2024201321A1

The present invention relates to a process for obtaining a dental prosthesis comprising a crown and tooth root. Said process comprises at least one step of directing undifferentiated cells or keratinocytes and at least one three-dimensional printing step, preferably 3D bioprinting of the dental prosthesis. Furthermore, the invention regards the dental prosthesis obtained with the process and a bioink suitable for three-dimensional printing (3D), preferably suitable for 3D bioprinting.