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一种带有螺硫吡喃基团的聚氨酯丙烯酸酯及其合成方法和应用

Resumen de: CN120757748A

本发明提供了一种带有螺硫吡喃基团的聚氨酯丙烯酸酯及其合成方法和应用，涉及义齿基托材料技术领域。带有螺硫吡喃基团的聚氨酯丙烯酸酯中将螺硫吡喃的C‑S弱共价键引入聚氨酯丙烯酸酯主链中，利用其在外力作用下易发生均裂的特性来耗散能量，并通过自由基介导的点击反应实现链间交联，从而增强机械强度，使其适用于义齿基托、口腔修复体、生物医学植入物等领域。

一种距下关节固定装置

Resumen de: CN223416347U

本实用新型提供了一种距下关节固定装置，属于医疗器械技术领域。该距下关节固定装置包括足托，足托套设在穿戴者的足跟部；足托包括底板以及设置在底板两侧顶端的第一侧板与第二侧板，第一侧板与第二侧板相对向内折弯，第一侧板与第二侧板顶端分别向底板方向凹陷形成有凹槽；第一侧板与第二侧板与穿戴者的脚踝相贴合。该距下关节固定装置结构简单，适应性好，能充分开放前足活动空间，减少穿戴不适感，达到用户自我锻炼重塑肌肉韧带及行走发力问题，安全性高。

功能化丝素蛋白基生物墨水、仿生软骨水凝胶及其制法

Resumen de: CN120754319A

本发明属于生物材料与组织工程技术领域，涉及一种功能化丝素蛋白基生物墨水、仿生软骨水凝胶及其制法。该墨水含有引发剂、SFMA、GelMA、PEGDA和OBC，各组分的配比严格控制；将该墨水与干细胞混合均匀后，引发固化交联反应，制成多重仿生软骨水凝胶。该水凝胶包括多重网络结构水凝胶以及同时分散在多重网络结构水凝胶中的OBC及干细胞，具有和真实软骨组织匹配的压缩模量以及多孔结构。本发明提供的功能化丝素蛋白基生物墨水及多重仿生软骨水凝胶，解决了现有技术中供体不足、免疫排斥、仿生维度单一、力学性能不匹配等问题，能实现高精度打印并高效促进软骨再生。

一种仿生灯笼框架复合内固定装置及制备方法

Resumen de: CN120753772A

本发明公开了一种仿生灯笼框架复合内固定装置及制备方法，涉及骨科医疗器械技术领域，包括植入体和多棒桥接结构，多棒桥接结构由多个纵向连接棒与横向锁定钉组成，植入体由多个多层级仿生结构组成，多层级仿生结构包括两个对称设置的六边形上下层结构以及设置在两个六边形上下层结构之间的中间螺旋层结构。本发明从蜂窝与耗牛角宏微观结构中受到启发，采用耦合仿生技术制备出的多层级仿生结构具有优异的力学性能，缓冲吸振能力强，可有效匹配天然骨力学性能，可有效避免患者植入后二次损伤和“应力屏蔽”效应，通过电化学沉积方法引入的复合涂层弥补了单一植入体结构生物相容性不足、抗菌性不足、成骨分化能力弱的问题。

一种运用3D打印技术制作可降解的乳房植入物的方法

Resumen de: CN120756090A

本申请提供了一种运用3D打印技术制作可降解的乳房植入物的方法，包括以下步骤：在3D打印喷头的加热腔内灌注打印材料；对加热腔加热至温度到达预设温度时3D打印设备开始打印工作，包括打印喷头的喷嘴挤出打印材料，并按预设程序在打印平台上方移动，保持加热腔温度稳定在预设温度；预设程序包括打印路径以预设图形的中心为起点，沿径向从内向外逐层打印，完成预设图形最后一层时打印工作结束；停止对加热腔的加热。通过加热腔稳定持续的加热，材料分子量逐渐减小，结合3D打印方法自预设图形由内向外逐层打印，使得乳房植入物的分子量自中心向外层逐层减小，解决了现有手段制作的乳房植入物的降解方向与细胞再生进程无法动态协同的问题。

BIOPRINTING METHODS AND SYSTEMS

Resumen de: AU2024230146A1

In a bioprinting system and method, a bioprinter may include one or more reservoirs, a printhead, and a print surface on which the bioprinting is dispensed. An optical system may collect imaging data of a plurality of cells within a cross-linkable material before, during and/or after passage of the plurality of cells through the bioprinting system. A computing system may process the imaging data to determine a quantity, distribution, concentration, and/or morphology of the plurality of cells. A machine learning system compares characteristics of the plurality of cells before, during and/or after passage of the plurality of cells through the bioprinting system to user-established cell morphologies corresponding to physical properties of cells and/or cell aggregates within a predetermined tolerance. Additionally or alternatively, the machine learning system compares characteristics of the plurality of cells at one stage in the bioprinting system to characteristics of the plurality of cells at another stage in the bioprinting system.

METHODS AND SYSTEMS FOR CUSTOM NIPPLE

Resumen de: WO2025213195A1

Methods and systems are described for creating a custom nipple generated from a custom mold based on a series of images of a nipple region.

MEDICATION TRACKING

Resumen de: US2025316367A1

A system and method is described for printing a label with an RFID tag. The system includes an RFID reader that queries a first RFID tag coupled to a first medicinal container that includes a medication. In response, the system receives a first unique identifier and uses the first unique identifier to determine a status of the medication, associate the first medicinal container with a medical provider and print a second label that includes a second RFID tag for a second medicinal container.

SYSTEM FOR CONTROLLABLE RELEASE IN 3D-PRINTED COLON TARGETING (CORR3CT) ORAL DOSAGE FORM

Resumen de: US2025312281A1

An oral dosage form for controllable release and method of forming are described. The oral dosage form includes a core layer including an active ingredient and a plurality of outer shell layers surrounding the core layer, the plurality of outer shell layers configured to disintegrate at a pH above a threshold. The method of forming the oral dosage form includes forming a core formulation paste including an active ingredient and forming an outer shell formulation paste configured to disintegrate at a pH above a threshold. The method further includes forming a wet tablet by sequentially depositing the outer shell formulation paste and the core formulation paste. The wet tablet is subsequently dried and cooled to produce the oral dosage form.

Method for Modeling Humeral Anatomy and Optimization of Component Design

Resumen de: US2025312163A1

Stemless components and fracture stems for joint arthroplasty, such as shoulder arthroplasty, are disclosed. Also, methods and devices are disclosed for the optimization of shoulder arthroplasty component design through the use of medical imaging data, such as computed tomography scan data.

Apparatus and Methods for Small Joint and Bony Defect Replacement

Resumen de: US2025312160A1

Apparatus and methods for joint and bony segment replacement may utilize additive manufacturing (e.g., 3D printing) of various anatomic constructs with PEEK/zeolite/ion (PZI) material. Heavy metal ion loading options may be utilized which may provide differing properties to different surfaces of the resultant apparatus. Moreover, using the PZI material, the apparatus being implanted in joint and bony segment replacement may favorably manipulate the biologic microenvironment in which it may be implanted. Further, through use of PZI material, current large joint replacement options also may be disrupted including, but not limited to, modifications of the joint replacement itself, and the augments and supporting joint reconstruction devices used in bone loss situations. Methods for joint and bony segment replacement may provide mixing two or more types of PZI material together through an additive manufacturing process; and introducing the mixture as part of an implantable apparatus.

SERIES OF DEVICES FOR PREPARING THE DISPLACEMENT, IN PARTICULAR A PERMANENT DISPLACEMENT, OF THE OCCLUSAL PLANE OF A PERSON, AND ASSOCIATED METHODS

Resumen de: US2025312125A1

A series (100) of devices for assisting in the displacement of the chewing plane of a person (P) is explained, comprisingat least two devices (10),wherein the devices (10) each comprise at least one jaw device (11, 12),wherein the at least one jaw device (11, 12) comprises an upper jaw device (11) and/or a lower jaw device (12),and wherein the devices (10) are designed to be worn by the person (P) according to a predetermined sequence.In at least one device (10.1, 10.2), the at least one jaw device (11, 12) comprises at least one height element on a first side. At least two contact areas, preferably local contact areas, are formed on the at least one height element at mutually different positions of molar elements. At least one further contact area is formed on a second side of the at least one jaw device (11, 12), in particular a further local contact area. The at least three contact areas define the plane (GE),wherein the plane (GE) deviates from a starting chewing plane of the person (P) or from a current chewing plane of the person (P) with respect to its inclination changed by the at least one height element in a frontal section or sagittal section and/or deviates with respect to its height position changed by the at least one height element, andwherein in at least one other device of the series (100) a different inclination in a frontal section or sagittal section and/or a different height position of the respective plane is adjusted by at least one further height eleme

COMPACT ENDOSCOPE DESIGN FOR THREE-DIMENSIONAL SURGICAL GUIDANCE

Resumen de: US2025311915A1

The present invention is directed to endoscopic structure illumination to provide simple, inexpensive 3D endoscopic technique to conduct high resolution 3D imagery for use in surgical guidance system. The present invention is directed to an FPP endoscopic imaging setup which provides a wide field of view (FOV) that addresses a quantitative depth information and can be integrated with commercially available endoscopes to provide tissue profilometry. Furthermore, by adapting a flexible camera calibration method for the 3D reconstruction technique in free space, the present invention provides an optimal fringe pattern for the inner tissue profile capturing within the endoscopic view and validate the method using both static and dynamic samples that exhibits a depth of field (DOF) of approximately 20 mm and a relative accuracy of 0.1% using a customized printed calibration board. The presented designs enable flexibility in controlling the deviated angle necessary for single scope integration using FPP method.

IMPLANT COMPRISING NONBIOLOGIC PORTION AND BIOLOGIC PORTION

Resumen de: US2025312159A1

In one aspect, an implant for replacing subject tissue includes a nonbiologic portion and a biologic portion grown on the nonbiologic portion. The biologic portion may be grown on the nonbiologic portion before being implanted in the subject. The nonbiologic portion may comprise a porous metal substrate (e.g., scaffolding). The nonbiologic portion may be formed by 3D printing (i.e., additive manufacturing). The nonbiologic portion may be patient-specific. A robot may be used to shape the implant before implantation and/or to shape bone being replaced/resurfaced.

AUTOMATED METHODS FOR DESIGNING AND FABRICATING AN INTRA-ORAL APPLIANCE

Resumen de: US2025312122A1

A method for designing a custom-made intra-oral appliance includes obtaining a virtual 3D reconstruction of an oral cavity, identifying an appliance region, obtaining a 3D appliance mesh from the appliance region, and processing the 3D appliance mesh for obtaining a volumetric appliance mesh. A method for obtaining a virtual 3D reconstruction of an oral cavity, the virtual 3D reconstruction being suitable for use in designing custom-made intra-oral appliances, and a method for designing an intra-oral appliance. The method for obtaining a virtual 3D reconstruction of an oral cavity includes obtaining at least one 2D image of an oral cavity, wherein the at least one image is acquired by a consumer electronics product, transforming the obtained at least one 2D image into an initial virtual 3D reconstruction of the oral cavity, and transferring information included in a further virtual 3D reconstruction to the initial virtual 3D reconstruction.

A MICROFLUIDIC DEVICE AND A METHOD OF FORMING THEREOF

Resumen de: AU2024233284A1

A method of manufacturing a patient-specific microfluidic device and a patient-specific microfluidic device are provided. The method includes obtaining three-dimensional (3D) information associated with vascular geometry in a region of interest from one or more clinical images associated with a patient, and fabricating the patient-specific microfluidic device using said 3D information. The patient-specific microfluidic device includes a flow channel having a geometry that substantially corresponds to the vascular geometry in the region of interest.

PATIENT-SPECIFIC HUMERAL HEAD GUIDE DEVICE AND SYSTEMS AND METHODS FOR MANUFACTURING SAME

Resumen de: US2025312048A1

A patient-specific humeral head guide device may be designed and manufactured to contour the shape of the humeral head of the patient, as determined from the medical images. For example, a system may generate computer-assisted manufacturing (CAM) instructions based on one or more medical images of the shoulder of the patient. The CAM instructions may include G-code that causes a three-dimensional (3D) printer to manufacture a patient-specific humeral head guide device. The system may generate G-code for other various portions of the patient-specific humeral head guide device. For example, the system may generate instructions for manufacturing a patient-specific humeral head guide device to include a footprint (including a body and an extended footprint) that contours the humeral head, a plurality of fixation wire channels (for drilling to receive a respective fixation wire), a reaming channel, a resection channel (for cutting), and/or other portions described herein.

COMPOSITE POSITIVE AND NEGATIVE POISSON’S RATIO TISSUE ADHESIVES

Resumen de: US2025312511A1

Some tissue adhesives include a solid having bio-absorbable fibers and at least one of nano-spheres, micro-spheres, nano-tubules, or micro-tubules. A first layer of the solid has a positive Poisson's ratio and a second layer of the solid has a negative Poisson's ratio. In some cases, the second layer has been transformed from a positive Poisson's ratio material to a negative Poisson's ratio material. In some cases, an entire face of the first layer is in contact with an entire face of the second layer. In some cases, the second layer includes one or more pores, at least a portion of the one or more pores containing a secretion from one or more barnacles. In some cases, the secretion is configured to adhere the tissue adhesive to one or more layers of tissue to at least partially close a wound.

DENTAL IMPLANTS

Resumen de: US2025312130A1

The present teachings relate to an assembled dental implant comprising a metallic body manufactured at least partially via an additive manufacturing process: wherein the body is provided with a cavity having an opening on one end of the body. and an inlay part at least partly introduced within the cavity and scalably connected with the metallic body thereby sealing-off the cavity. The present teachings also relate to the metallic dental implant body and manufacturing methods.

Integrally formed medical devices

Resumen de: AU2025234230A1

INTEGRALLY FORMED MEDICAL DEVICES Abstract Disclosed herein are integrally formed medical devices and methods relating thereto. One embodiment provides an integrally formed patient-specific medical device comprising: a substantially trapezoidal body portion having at least one surface that is contoured to fit an anatomy of a patient; and a graft window defining a vertical aperture through said body portion, such that said body portion defines a cage. INTEGRALLY FORMED MEDICAL DEVICES Abstract Disclosed herein are integrally formed medical devices and methods relating thereto. One embodiment provides an integrally formed patient-specific medical device comprising: a substantially trapezoidal body portion having at least one surface that is contoured to fit an anatomy of a patient; and a graft window defining a vertical aperture through said body portion, such that said body portion defines a cage. ep e p b s t r a c t i s c l o s e d h e r e i n a r e i n t e g r a l l y f o r m e d m e d i c a l d e v i c e s a n d m e t h o d s r e l a t i n g t h e r e t o n e e m b o d i m e n t p r o v i d e s a n i n t e g r a l l y f o r m e d p a t i e n t - s p e c i f i c m e d i c a l d e v i c e c o m p r i s i n g : a s u b s t a n t i a l l y t r a p e z o i d a l b o d y p o r t i o n h a v i n g a t l e a s t o n e s u r f a c e t h a t i s c o n t o u r e d t o f i t a n a n a t o m y o f a p a t i e n t ; a n d a g r a f t w i n d o w d e f i n i n g a v e r t i c a l a p e r

METHOD FOR MANUFACTURING POLYMER-BASED MICRONEEDLE PATCH AND MICRONEEDLE PATCH MANUFACTURED THEREBY

Resumen de: US2025312584A1

The present invention relates to a method for manufacturing a polymer-based microneedle patch designed to maximize skin penetration performance. The polymer-based microneedle patch of the present disclosure can be manufactured to have enhanced penetration power and flexibility as microneedles formed of a polymer with both rigidity and flexibility are combined with an elastic and breathable substrate.

AUTOMATED MANAGEMENT OF CLINICAL MODIFICATIONS TO TREATMENT PLANS USING THREE-DIMENSIONAL CONTROLS

Resumen de: CN117412727A

Methods and apparatus, including systems, for forming and modifying treatment plans, including modifying treatment plans in real time. A method and apparatus for modifying orthodontic treatment plans in real time may include using an enhanced user interface including 3D user coverage.

MATRICES FOR WOUND HEALING

Resumen de: AU2023403078A1

The present invention provides articles for the improved healing of wounds, preferably burn wounds. In some preferred embodiments, the article is a matrix formed from a mixture of two or more polysaccharides, the matrix comprising an active ingredient which is an extract from differentiable cells.

RADIATION DOSIMETRY APPARATUS AND RELATED METHODS

Resumen de: WO2024113056A1

A radiation dosimetry apparatus comprises a body that supports scintillator elements that emit light when exposed to radiation. The body may be shaped to conform to contours of a portion of a patient's anatomy. Radiation intensity and dose may be determined by processing images obtained by one or more cameras to measure intensity of light emitted by different ones of the scintillator elements. The scintillator elements may be distributed non-uniformly based on a patient-specific radiation treatment plan. Scintillator elements may be arranged to provide increased spatial resolution and/or dose resolution in higher dose regions and/or regions corresponding to organs at risk. Radiation dosimeter apparatuses may be fabricated by additive manufacturing. Design and fabrication of the radiation dosimetry apparatuses may be integrated into workflows in clinical radiation treatment settings. Methods and systems for fabricating, calibrating, and using the radiation dosimetry apparatuses are described.

3D PRINTING OF HIGH CELL DENSITY VASCULARIZED TISSUE

Resumen de: WO2024118942A1

A composition and method for 3D bioprinting adds a contrast agent having a relatively high refractive index to a photopolymerizable bioink composition in which cells are encapsulated so that the refractive index of the composition substantially matches the refractive index of the encapsulated cells.

THREE-DIMENSIONAL TOOTH MODEL SEGMENTATION METHOD AND APPARATUS

Resumen de: EP4629181A1

The disclosure relates to a method and apparatus for cutting a three-dimensional tooth model. The method includes: obtaining a two-dimensional projection image of a three-dimensional tooth model, and recognizing the two-dimensional projection image to obtain a plurality of tooth regions, where the tooth regions correspond one to one to teeth; determining original seed points corresponding to the plurality of tooth regions in the three-dimensional tooth model; expanding the original seed points within a preset range to obtain target seed points of the teeth in the three-dimensional tooth model; and cutting the three-dimensional tooth model based on the target seed points of the teeth to obtain cut teeth. The present disclosure solves the technical problem of low tooth-cutting accuracy on the three-dimensional tooth model.

VARIOUS STRUCTURED SUPPORTS FOR 3D PRINTED ALIGNERS/MOUTH PIECES

Resumen de: EP4628048A2

A support is coupled to an appliance to decrease warpage. The support may comprise a plurality of extensions coupled to the appliance to decrease warpage. The extensions can be coupled to the appliance at one or more of many locations, such as on an occlusal surface, a wall, an edge or an interior of the appliance. In some embodiments, the extensions are coupled to walls of the appliance such as a buccal wall and a lingual wall, and the extensions can be coupled to the walls of the appliance near edges of the walls, such as a gingivally facing edges of the walls that are oriented toward the gingiva when the appliance is worn.

MATERIAL AND METHOD FOR PRODUCING CELL RECEIVING SCAFFOLD

Resumen de: EP4628303A2

A printable composition for the manufacture of cell-receiving scaffolds comprising about 0.3 wt% to about 3.0 wt% of one or more collagens; about 5.0 wt% to about 40.0 wt% of one or more monomers; about 0.5 wt% to about 2.0 wt% of a photo initiator; and 0 wt% to about 75 wt% of a vehicle comprising a protic solvent, by weight of the printable composition; wherein the printable composition has a resolution of about 100 microns or less when printed, a photo speed (Dp/Ec) of about 0.1-5 mm (Dp) and about 10-100 mJ/cm² (Ec) when printed, and a green strength of at least about 5 kPa after drying. The present technology further includes methods of manufacturing a three-dimensional cell-receiving scaffold using the printable composition.

一种纯Fe、Fe基合金或Fe基复合材料多孔支架及其制备方法与应用

Resumen de: CN120734347A

本发明公开了一种纯Fe、Fe基合金或Fe基复合材料多孔支架及其制备方法与应用。采用热水与常温水复配配制羟丙基甲基纤维素水溶液作为粘结剂，以含(几)微米尺寸Fe粉为原料。通过脱泡制备3D打印浆料。在打印过程中对支架底部进行加热，以帮助其快速干燥成型，最后脱脂和烧结得到多孔支架。本发明具有广泛的适用性，所制备的纯Fe、Fe基合金或Fe基复合材料支架展现出较高的支柱致密度和优异的力学性能。此外，由于Fe粉粒径较细，粉末颗粒之间的结合更加紧密，从而减少了支架发生不均匀腐蚀的可能性。

一种基于3D打印的聚醚醚酮/羟基磷灰石支架的制备方法及应用

Resumen de: CN120733116A

本发明提出了一种基于3D打印的聚醚醚酮/羟基磷灰石支架的制备方法，涉及医疗器械技术领域。包括：首先构建一个圆柱体空间，内部填充随机分布的种子点，在相邻的种子点之间进行分面和修剪，得到初始支架框架；将聚醚醚酮纳米粉和微米级羟基磷灰石粉末充分混合，烘干后备用；将聚醚醚酮/羟基磷灰石粉料用于3D打印，打印后得到聚醚醚酮/羟基磷灰石块状材料，然后用砂纸对其进行打磨，并用超纯水超声清洗,烘干，得到聚醚醚酮/羟基磷灰石支架；本发明制备的支架具备良好的降解性能、力学强度、对成骨也有显著的促进作用。本发明方法制得的聚醚醚酮/羟基磷灰石支架可以用于颅骨修复领域，其能够诱导骨再生，进而促进骨组织修复，新骨形成。

頭蓋矯正目標データ提供システム、頭蓋矯正目標データ提供プログラム及び頭蓋矯正目標データ提供方法

Resumen de: JP2025145463A

【課題】症例に適した頭蓋矯正目標データをより好適に得ることのできる頭蓋矯正目標データ提供システム、頭蓋矯正目標データ提供プログラム及び頭蓋矯正目標データ提供方法を提供する。【解決手段】頭蓋矯正目標データ提供システム１０は、被験者１００の頭蓋形状に基づく頭蓋形状データＤ１６を記憶する記憶部７０と、頭蓋形状データＤ１６を機械学習された生成モデルＤ５０に適用するために頭蓋形状データＤ１６を前処理して前処理済みデータを生成する前処理部２１と、前処理済みデータを生成モデルＤ５０に適用して生成データを生成する生成モデル適用部２２と、生成データに後処理した頭蓋矯正目標データＤ２０を生成する後処理部とを備える。生成モデルＤ５０は、複数の過去症例に対応する教師データを学習して得られたモデルであり、教師データは、任意の被験者の頭蓋形状データＤ１６と当該任意の被験者の頭蓋矯正目標データＤ２０とを一組として含む。【選択図】図１

ELECTRODE STRUCTURE FOR ELECTRICAL STIMULATION

Resumen de: WO2025206723A1

An electrode structure for electrical stimulation according to an embodiment comprises: an electrode wire; and an electrode unit disposed on the outer surface of the electrode wire and including a plurality of electrode lines spaced apart from each other, wherein each of the plurality of electrode lines of the electrode unit is disposed in direct contact with the outer surface of the electrode wire.

Aufsatz; Verfahren zur Herstellung eines Aufsatzes; Verfahren zur Auswahl eines geeigneten Aufsatzes zur zumindest teilweisen Abdeckung einer Knochendefektstelle

Resumen de: DE102024109164A1

Es werden ein Aufsatz (1), ein Verfahren zur Herstellung eines Aufsatzes (1) und ein Verfahren zur Auswahl eines geeigneten Aufsatzes (1) zur zumindest teilweisen Abdeckung einer Knochendefektstelle vorgeschlagen, wobei der Aufsatz (1), zur zumindest teilweisen Abdeckung einer Knochendefektstelle, eine Ausdehnung in einer ersten Richtung x in einer dazu orthogonalen Richtung y und einer zur x und y orthogonalen Richtung z hat, und der Aufsatz (1) und/oder mindestens ein an dem Aufsatz (1) angebrachtes Versteifungselement (3) zumindest teilweise aus einem Material besteht, welches einen Formgedächtniseffekt und/oder eine derart große Rückstellkraft aufweist, um nach einer elastischen Verformung wieder in seinen Ausgangszustand zurückzukehren.

3D AXIAL GROWTH OBJECT, AND APPARATUS FOR AND METHOD OF MAKING THEREOF

Resumen de: US2025302609A1

A 3D object including a support structure formed with a mesh layer and an intermediate support structure; and one or more additive layers of substrate material formed via an axial growth process in which the substrate material formed a film over mesh holes in the mesh layer, thereby forming a continuous surface where the mesh holed previously existed.

SPINAL INTERBODY FUSION DEVICE

Resumen de: US2025302637A1

A bellows shaped spinal implant, comprising an upper plate, a lower plate and a bellows shaped shell extending between and joining the upper and lower plates. The bellows shaped shell is formed of titanium or an alloy comprising titanium and includes a wall extending therearound that defines a hollow interior. The wall has a thickness in the range of 0.5 mm to 1.0 mm to provide for radiographic imaging through the wall. The wall is angled or curved inwardly or outwardly between the upper and lower plates to provide stiffness mimicking the stiffness properties of a similarly sized polyetheretherketone (PEEK) implant. The upper and lower plates each comprise porous contact regions including a three-dimensional gyroid lattice structure defined by a plurality of struts and pores in communication with the hollow interior. The outer surfaces of at least a portion of the struts may comprise a laser ablated textured surface.

METHODS, DEVICES, AND MANUFACTURE OF THE DEVICES FOR MUSCULOSKELETAL RECONSTRUCTIVE SURGERY

Resumen de: US2025302512A1

A device used in conjunction with fixation hardware to provide a two-stage process to address the competing needs of immobilization and re-establishment of normal stress-strain trajectories in grafted bone. A method of determining a patient-specific stress/strain pattern that utilizes a model based on 3D CT data of the relevant structures and cross-sectional data of the three major chewing muscles. The forces on each of the chewing muscles are determined based on the model using predetermined bite forces such that a stiffness of cortical bone in the patient's mandible is determined. Based on the stiffness data, suitable implantation hardware can be designed for the patient by adjusting external topological and internal porous geometries that reduce the stiffness of biocompatible metals to thereby restore normal bite forces of the patient. A method of 3D printing nitinol to create a patient-specific device to facilitate the establishment of a normal stress-strain trajectory in grafted bone.

Bauteil mit einer mineralisierten Polymerstruktur sowie ein Verfahren zu dessen Herstellung

Resumen de: DE102024202854A1

Bei einem Verfahren zur Herstellung eines mineralisierten Polymerbauteils wird ausgehend von einem Bilddatensatz eine Stützstruktur (1) aus einem polymerbasierten Werkstoff ausgebildet, wobei die Stützstruktur (1) mindestens einen ersten Bereich (5), in dem der polymerbasierte Werkstoff ausgebildet ist und mindestens einen zweiten Bereich (2), der als Hohlstruktur ausgebildet ist, aufweist. Anschließend wird auf der Oberfläche der Stützstruktur (1) und/oder innerhalb des ersten Bereichs (5) und/oder auf mindestens einer inneren Oberfläche des ersten Bereichs (5) mindestens eine anorganische Mineralphase ausgebildet.

METHOD FOR MANUFACTURING HIGH-TRANSMITTANCE LITHIUM DISILICATE GLASS CERAMIC BY MEANS OF PHOTOCURING ADDITIVE MANUFACTURING

Resumen de: WO2025200465A1

The present invention relates to a method for manufacturing a high-transmittance lithium disilicate glass ceramic by means of photocuring additive manufacturing, comprising: adding anhydrous ethanol to prepared powder, carrying out ball milling for uniform mixing and then drying the mixture, and carrying out heat treatment to obtain a molten mixture; dropwise adding the molten mixture to flowing deionized water for quenching to form initial particles; ball-milling and sieving the initial particles to prepare powder having a particle size of 0.3-0.5 μm and carrying out spray drying granulation to obtain 5-25 μm glass ceramic particles; adding the glass ceramic particles to a prepared resin mixture, putting the obtained mixture into a roller press to prepare a paste, and then carrying out vacuum defoaming; carrying out photocuring formation on the paste by means of an additive manufacturing device to obtain a green body; using a flowing cleaning solution to clean the green body and then drying the green body; and degreasing the dried green body in vacuum or an inert gas, then carrying out vacuum impregnation in a lithium polysilicate solution, and then carrying out sintering and ion exchange to obtain a finished product. The present invention solves the problem of insufficient strength or low light transmittance of a lithium disilicate glass ceramic obtained by additive manufacturing.

METHOD FOR MANUFACTURING LITHIUM DISILICATE GLASS CERAMIC WITH GRADIENT PROPERTIES BY USING PHOTOCURING ADDITIVE MANUFACTURING

Resumen de: WO2025200466A1

A method for manufacturing a lithium disilicate glass ceramic with gradient properties by using photocuring additive manufacturing, the method comprising: performing wet mixing on a basic glass powder with a solvent, ball milling same until uniformity, drying same, then performing thermal treatment to reach a molten state, then quenching same to form original particles, and then granulating same to obtain lithium disilicate ceramic particles; respectively preparing n groups of pastes with gradually-changing colors and translucencies from n groups of the lithium disilicate ceramic particles, said paste preparation comprising: adding 3Y-TZP powder, a coloring agent and lithium disilicate ceramic particles to a resin mixture, mixing same, rolling same and performing vacuum defoaming to obtain a paste; adding the n groups of pastes in sequence into an additive manufacturing device to undergo photocuring forming, so as to obtain a green body; after the green body is cleaned and dried, degreasing the green body, and sintering same; and finally under a vacuum high-temperature condition, subjecting the sintered sample to an ion exchange reaction with a molten nitrate in a flowing state, so as to obtain a product.

SMART INTERACTIVE SHIRT SYSTEM FOR REAL-TIME MULTI-MODAL PAIN AND FATIGUE MONITORING USING EMBEDDED IOT SENSORS

Resumen de: WO2025206987A1

The Smart Interactive Shirt System is an advanced wearable biosensing platform engineered for real-time, multi-modal monitoring and predictive management of pain, fatigue, and physiological stress. Embedded within a flexible textile, the system integrates 15 specialized IoT sensors—spanning biochemical, biomechanical, thermal, and neurophysiological domains—to deliver continuous high-resolution insight into the wearer's physiological state. Key innovations include plasmonic nano-optical modules for real-time cortisol and CRP detection, EMG-based neuromuscular sensing, and thermopile arrays for deep-tissue inflammation mapping. A hybrid AI engine combining convolutional and recurrent neural networks (CNN-LSTM) processes incoming data locally, enabling early prediction of acute fatigue and pain episodes 10-15 minutes before physiological onset. The system incorporates triboelectric nanogenerators (TENGs) that harvest kinetic energy from body motion, minimizing reliance on external power sources and supporting extended autonomous operation. Validated through pilot deployments in elite European sports organizations, the shirt also features screen-printed electronic circuits, vibrotactile feedback mechanisms, and seamless Bluetooth Low Energy (BLE) integration with mobile interfaces. This invention marks a significant advancement over conventional wearables by offering proactive, data-driven physiological management, setting a new benchmark in intelligent, AI-powered textile s

DENTAL MODEL AND ASSOCIATED DENTAL IMPLANT ANALOG

Resumen de: WO2025202283A1

The present disclosure relates to a dental model of at least a part of a patient's jaw and/or teeth, the dental model comprising: at least one analog pocket, each analog pocket defining a longitudinal cavity, wherein each analog pocket comprises one or more retention features for securing a dental implant analog within the cavity, wherein at least one retention feature comprises one or more elastic and radially compressible elements formed as part of a wall positioned in front of a different cavity from the longitudinal cavity, the wall forming a part of the analog pocket and being configured to deform and adapt to the implant analog during insertion of the implant analog within the analog pocket. The present disclosure also relates to a dental implant analog for insertion into the dental model, a dental tool or restoration kit, and a method of manufacturing a dental model.

COMPONENT HAVING A MINERALISED POLYMER STRUCTURE AND METHOD FOR THE PRODUCTION THEREOF

Resumen de: WO2025202052A1

In a method for producing a mineralised polymer component, a support structure (1) made of a polymer-based material is formed on the basis of an image data set, wherein the support structure (1) has at least one first region (5), in which the polymer-based material is formed, and at least one second region (2), which is designed as a hollow structure. Subsequently, at least one inorganic mineral phase is formed on the surface of the support structure (1) and/or within the first region (5) and/or on at least one inner surface of the first region (5).

BONE STABILIZING IMPLANTS AND METHODS OF PLACEMENT ACROSS SI JOINTS

Resumen de: AU2025230762A1

Abstract The invention relates to a threaded bone implant, comprising: an elongate body extending from a proximal end of the bone implant to a distal end of the bone implant, the elongate body including an inner shank, one or more threads, each of which extend radially from the inner shank and extend along at least a portion of a length of the elongate body, a porous network of interconnected struts extending radially from the inner shank and disposed and extending axially between the one or more threads, the inner shank, the one or more threads, and the porous network of interconnected struts being formed together with an additive manufacturing process such that the inner shank, the one or more threads, and the porous network of interconnected struts are integral, and wherein the porous network of interconnected struts has a greater surface area in a central region of the elongate body than in a distal region of the elongate body, wherein the central region includes a midpoint of the length of the elongate body. Abstract The invention relates to a threaded bone implant, comprising: an elongate body extending from a proximal end of the bone implant to a distal end of the bone implant, the elongate body including an inner shank, one or more threads, each of which extend radially from the inner shank and extend along at least a portion of a length of the elongate body, a porous network of interconnected struts extending radially from the inner shank and disposed and extending a

Augmented, Just-in-Time, Patient-Specific Implant Manufacture

Resumen de: US2025302640A1

A bone part is repaired by a process. A first implant is attached to a first bone part. The first implant corresponds to an intraoperatively defined or an intraoperatively selected cutting path. A preoperatively defined second implant is attached to the first implant. The first implant and the second implant together augment the first bone part.

ORTHODONTIC SYSTEMS AND METHODS OF USING SAME

Resumen de: US2025302591A1

In some embodiments, apparatuses and methods are provided herein useful to orthodontic systems. In some embodiments, an orthodontic system comprises a registration assembly comprising a first main body, at least one registration feature configured to contact a feature in a patient's mouth to align the orthodontic system in the patient's mouth, and a first mating element including at least one post extending from the first main body, and an appliance assembly comprising a second main body, a plurality of support structures extending from the second main body, a plurality of orthodontic appliances secured to the second main body via the plurality of support structures, and at least one aperture extending into the second main body, wherein the at least one aperture is configured to mate with the first mating element.

SYSTEMS OF ORTHODONTIC APPLIANCES WITH PRECISION CUTS

Resumen de: US2025302589A1

Each of a plurality of pairs orthodontic appliances to reposition a dentition may include an upper shell that may include a first plurality of tooth-receiving cavities and an upper cutout disposed along an upper edge of the upper shell in a location of an upper elastic band receiving member. Each of the plurality of pairs orthodontic appliances may include a lower shell that may include a second plurality of tooth-receiving cavities and a lower cutout disposed along a lower edge of the lower shell in a location of a lower elastic band receiving member. The location of the upper elastic band receiving member and the lower elastic band receiving member may be configured to generate a repositioning force for repositioning the dentition from the initial arrangement towards a target arrangement when an elastic band is secured to the upper elastic band receiving member and the lower elastic band receiving member.

HIGH-THROUGHPUT AND HIGH-PRECISION PHARMACEUTICAL ADDITIVE MANUFACTURING SYSTEM

Resumen de: US2025303640A1

The present disclosure relates generally to manufacturing pharmaceutical products using additive manufacturing technology. An exemplary printing system comprises: a material supply module for receiving a set of printing materials; a flow distribution module comprising a flow distribution plate, wherein the material supply module is configured to transport a single flow corresponding to the set of printing materials to the flow distribution plate; wherein the flow distribution plate comprises a plurality of channels for dividing the single flow into a plurality of flows; a plurality of nozzles, wherein the plurality of nozzles comprises a plurality of needle-valve mechanisms; one or more controllers for controlling the plurality of needle-valve mechanisms to dispense the plurality of flows based on a plurality of nozzle-specific parameters; and a printing platform configured to receive the dispensed plurality of flows, wherein the printing platform is configured to move to form a batch of the pharmaceutical product.

AN ARTIFICIAL INTELLIGENCE ENABLED WEARABLE ECG SKIN PATCH TO DETECT SUDDEN CARDIAC ARREST

Resumen de: US2025308696A1

There is described an artificial intelligence wearable ECG skin patch (400) to detect sudden cardiac arrest. The wearable ECG monitoring patch (400) with AI based predictive analytics and remote based cardiac monitoring (615) system that can detect cardiac arrhythmias automatically in real-time and make a diagnosis with AI models trained with acquired data. The wearable skin has a biocompatible polymer patch (400) which captures the electrical signal through a flexible printed electronic technology based conducting ink and a substrate. The microcontroller controls (201), store and transmit the data packets. The IoT connected signal transmission is capable of recording and transferring the data packets through wireless communication. The AI engine is capable of analysing, evaluating, testing and providing the data packets of sudden cardiac arrest through a peak detector algorithm. The ECG skin patch (400) to detect and measure the sudden cardiac arrest with the R-R interval time series to obtain heart rate variability.

A 3-D POROUS SCAFFOLD

Resumen de: WO2025202519A1

Described herein is a 3-D porous scaffold for biological and medical applications such as a tissue engineering construct, a scaffold for drug delivery, a tissue culture scaffold, a scaffold for growing tissue and organoids, and as a 3-D substrate for organ-on-chip applications. The 3-D scaffold is generally 3-D printed. The scaffold has a layered structure comprising one scaffold layer or a plurality of scaffold layers associated together. Each scaffold may be printed as a monolith, or the layers can be printed separately and adhered together post-printing. Each scaffold layer comprises an array of Modular Units (M.U) that interconnect to form inter-unit pores. Each Modular Unit of the scaffold comprises a plurality of concentric circular struts namely annuluses and struts connecting the annuluses (hereafter "connecting strut") and intra-unit pores between the circular struts. The scaffold layers thus have a defined porosity and compressive stiffness, and the porosity and compressive stiffness can be controlled by the number, dimension and arrangement of the Modular Units in each of the scaffold layers.

CURABLE COMPOSITION FOR USE IN A PROCESS OF TREATING A DENTAL SITUATION IN THE MOUTH OF A PATIENT

Resumen de: CN120187382A

The present invention relates to a curable composition for use in a method of treating a dental condition in the oral cavity of a patient, the curable composition comprising a radiation curable component; a photoinitiator that exhibits absorption in the ultraviolet light region and exhibits absorption in the visible light region, the absorption in the ultraviolet light region being stronger than the absorption in the visible light region; optionally, a filler; optionally, an additive; the method comprises the steps of: layer-by-layer manufacturing of a dental or orthodontic article using radiation having a wavelength in the region of the ultraviolet light; attaching the dental or orthodontic article to a surface of hard dental tissue or dental material; radiation having a wavelength in the visible light region is applied to the dental or orthodontic article.

MEDICAL DEVICES AND RELATED METHODS

Resumen de: EP4624159A2

The present invention discloses a medical device, comprising: an operating member including an actuation portion, wherein a distal portion of the actuation portion includes two prongs offset from each other, and wherein each prong includes an extension face and a retraction face; a hub that includes a channel receiving the actuation portion of the operating member, wherein the actuation portion of the operating member is movable within the channel; and a first arm and a second arm that are movable between a closed configuration and an open configuration, wherein each of the first arm and the second arm includes a control portion that extends within the hub to interact with the actuation portion of the operating member, and wherein the control portions of the first and second arms each includes an extension surface and a retraction surface offset from the extension surface, wherein the actuation portion is extendable distally to cause the extension face of one prong to contact the extension surface of one of the first and second arms and transition the one of the first and second arms to the open configuration, and wherein the actuation portion is retractable proximally to cause the retraction face of the one prong to contact the retraction surface of the other one of the first and second arms and transition the other one of the first and second arms to the closed configuration.

TRANSFER APPARATUS FOR ORTHODONTIC APPLIANCES AND RELATED METHODS OF MANUFACTURING

Resumen de: EP4623859A2

A physical mockup for creating a transfer apparatus comprises a representation of at least a portion of a dental arch. The dental arch includes a plurality of teeth. Each tooth includes an occlusal surface, a lingual surface, and a labial surface. One or more teeth include an alignment pin projecting upward from the occlusal surface.

SYSTEMS AND METHODS OF USING THREE-DIMENSIONAL IMAGE RECONSTRUCTION TO AID IN ASSESSING BONE OR SOFT TISSUE ABERRATIONS FOR ORTHOPEDIC SURGERY

Resumen de: MX2025011109A

Systems and methods for calculating external bone loss for alignment of pre-diseasedjoints comprising: generating a three-dimensional ("3D") computer model of an operative area from at least two two-dimensional ("2D") radiographic images, wherein at least a first radiographic image is captured at a first position, and wherein at least a second radiographic image is captured at a second position, and wherein the first position is different than the second position; identifying an area of bone loss on the 3D computer model; and applying a surface adjustment algorithm to calculate an external missing bone surface fitting the area of bone loss.

三维仿生角膜基质支架的梯度生物墨水及3D打印制备工艺

Resumen de: CN120714102A

本发明提供三维仿生角膜基质支架的梯度生物墨水及3D打印制备工艺，所述梯度生物墨水包含5‑30份天然聚合物基质、2‑8份生物活性因子、1‑5份细胞成分、1‑10份光固化剂及60‑95份生理盐水。天然聚合物基质含甲基丙烯酰化明胶、胶原/透明质酸蛋白复合物和壳聚糖，其中胶原/透明质酸复合物经赖氨酰氧化酶交联与可见光光固化制得。生物墨水制备后，采用挤出式3D打印机，在特定条件下逐层打印，同步以紫外光照射，制得三维仿生角膜基质支架。本发明支架具有良好的力学性能、透光性及细胞相容性，可支持干细胞定向分化，适用于角膜修复。

布置多个齿科模型的方法

Resumen de: CN120716178A

本申请涉及一种布置多个齿科模型的方法，该方法包括：将多个齿科模型分为牙模模型和非牙模模型；将至少两个牙模模型编为一组；将至少一个非牙模模型编为一组；并且对至少一组牙模模型和/或至少一组非牙模模型进行排版。本申请能够兼顾批量3D打印制造的效率和后续分拣的简便性。

一种多材料药片3D打印装置

Resumen de: CN223392685U

本实用新型涉及一种多材料药片3D打印装置，属于医疗器械技术领域，包括：机架、成型系统、供粉系统及喷液系统，机架的内部固定有固定板且固定板上设有长条孔；成型系统沿X轴滑动在长条孔内；供粉系统包括支撑架和多个供粉斗，支撑架固定在固定板上；多个供粉斗沿X轴方向间隔固定在支撑架上且其漏粉孔可分别与多个容粉孔相对布置；喷液系统包括Y轴驱动机构和多个喷射器，Y轴驱动机构固定在机架上且其驱动端沿Y轴方向往复移动；多个喷射器间隔固定在Y轴驱动机构的驱动端。本实用新型突破传统3D打印机单一配比打印药物的设计束缚，匹配全新的药物喷射粘结技术，可以灵活配比多种材料，提高药片的成型效率和成型效果。

一种个性化牙齿3D打印设备及其方法

Resumen de: CN120716173A

本发明涉及打印设备技术领域，且公开了一种个性化牙齿3D打印设备及其方法，包括打印机和设置在打印机上的料盒，所述打印机内设置有成型板，还包括：升降部，所述升降部安装在打印机上；安装部，所述安装部设置在打印机上；所述升降部包括传动组件，所述传动组件设置有两个，两个所述传动组件均安装在打印机上；以及动力组件，所述动力组件设置在打印机上；所述传动组件包括固定连接在打印机上的固定杆一，所述固定杆一内滑动连接有滑杆一。本发明通过设置设置升降部，解决了现有的打印设备在使用过程中，动力传递多采用单组齿轮齿条或简单连杆结构，难以保证两侧运动的同步性，成型板易出现倾斜或偏移，导致打印材料堆叠不均匀问题。

用于改变颏短平形态的颏成形导板系统及其制作方法

Resumen de: CN120713588A

本发明提供了一种用于改变颏短平形态的颏成形导板系统及其制作方法，颏成形导板系统包括截骨导板和定位导板，所述截骨导板包括第一定位孔、第二定位孔和第三定位孔，并且限定了第一截骨骨块、第二截骨骨块和截骨去除骨块的切割引导路径，所述第一定位孔、所述第二定位孔和所述第三定位孔分别对应于所述第一截骨骨块、所述第二截骨骨块和下颌骨固位区域上的连接孔位；所述定位导板用于将截取的所述第一截骨骨块和所述第二截骨骨块限定在依据手术规划的目标位置，其包括第四定位孔、第五定位孔和第六定位孔，所述第四定位孔、所述第五定位孔和所述第六定位孔分别对应于所述第一截骨骨块、所述第二截骨骨块和所述下颌骨固位区域上的连接孔位。

一种异种骨-微孔金属植入物复合材料的制备方法

Resumen de: CN120714106A

本发明公开了一种异种骨‑微孔金属植入物复合材料的制备方法，属于生物技术领域；将微孔金属植入物植入到异种动物松质骨中，经过12周时间，微孔金属植入物与异种动物松质骨进行骨整合连接，形成界面互穿结构，将微孔金属植入物取出，保留1mm‑10mm厚度的周围骨，再依次进行梯度脱钙和完全脱细胞处理，获得具有高骨诱导活性、强骨整合性和低免疫原性的异种骨‑微孔金属植入物复合材料；本发明将金属植入物材料转变为生物活性植入物复合材料，将金属植入物与移植骨的异质界面转变为宿主骨或移植骨与移植骨的同质界面，解决了移植骨与金属植入物界面骨整合不良的临床难题。

薬学的複合体を混合するための方法及びアダプタ

Resumen de: CN120322290A

Embodiments of an adapter (100), a system including the adapter, and a method of using the adapter may be used to mix a first substance and a second substance. The adapter (100) can comprise a main body (101), the body has a first port (102) configured to be connected with a first container to receive a first substance, a second port (104) configured to be connected with a second container to receive a second substance, a third port (130) configured to be connected with a receiving container to output a mixture of the first substance and the second substance, and a mixing chamber, the mixing chamber has a first portion in communication with the first port and the second port and a second portion in communication with the third port. The adapter may also include a mixing pin (160) inserted into the mixing chamber. In some embodiments, the mixing pin at least partially defines at least one microfluidic path for mixing the first substance and the second substance. In some embodiments, at least one of the first channel and the second channel is oriented offset from a central plane of the body.

患者インタフェース並びに位置決め及び安定化構造

Resumen de: US2023285703A1

A patient interface comprises a plenum chamber and at least three plenum chamber inlet ports. A seal-forming structure is arranged to form a seal at least an entrance to the patient's nares and to maintain a therapeutic pressure in the plenum chamber throughout the patient's respiratory cycle. The interface further comprises a positioning and stabilising structure comprising at least four straps, at least three of the straps defining a channel therein, wherein a conduit is provided within each channel. Each conduit comprises an interface connector for connecting the conduit to a respective one of the inlet ports and a connection port for connection, in use, to an air circuit, wherein the connection port is in fluid communication with each of the conduits. The plenum chamber is provided with at least one pressure measurement port. A positioning and stabilising structure is also disclosed.

Design and production of artificial scaffold in the form of a nasal implant for rhinoplasty and regeneration method of nasal cartilage tissue

Resumen de: KR20250141443A

본 발명은 코 성형을 위한 코 보형물 형태의 인공지지체 설계 및 제작과 코 연골조직의 재생 방법에 관한 것이다.

患者インターフェース

Resumen de: US2025161616A1

A patient interface comprises a support structure and a seal-forming structure. The support structure is arranged to support the sealing portion and is configured to connect to the frame. The sealing portion comprises textile and is attached to the support structure along an outer perimeter of the sealing portion such that in use the sealing portion may be in tension due to reactive stress of the support structure and/or a resilient stretch characteristic of the textile such that the sealing portion exerts a force against the patient's face.

用于经由装载有API的组织穿透器递送药物的装置和方法

Resumen de: WO2024163831A1

A drug delivery device includes a substrate; and a plurality of tissue penetrating members 3D printed onto the substrate and configured to embed into tissue, wherein at least one of the plurality of tissue penetrating members is configured to anchor the drug delivery device to the tissue; and at least one payload comprising at least one API loaded into at least one of the substrate and the plurality of tissue penetrating members for absorbing into the tissue when the at least one tissue penetrating member is embedded in the tissue.

3D打印水凝胶前驱体溶液、固化产物及其制备方法和应用

Resumen de: CN120699378A

本申请涉及材料技术领域，提供了3D打印水凝胶前驱体溶液、固化产物及其制备方法和应用。该3D打印水凝胶前驱体溶液，按质量百分数计，包括如下组分：表面活性剂5％～35％、丙烯酰胺5％～30％、疏水单体0.5％～5％、水溶性聚合物0.05％～5％、光引发剂1％～5％，余量为硫酸钠溶液。本申请的3D打印水凝胶前驱体溶液，适用于光固化3D打印，能够在光作用下固化形成3D打印水凝胶，形成的3D打印水凝胶同时兼具良好的力学性能和自修复特性，在一些对强度、持久性要求较高的应用场景下具有良好的适应性，具有广阔的推广应用前景。

一种3D打印前臂假肢

Resumen de: CN223380672U

本实用新型涉及假肢技术领域，且公开了一种3D打印前臂假肢，包括内外接受腔，所述内外接受腔的表面套接有上仿真皮，所述内外接受腔的表面设有透气孔和盖板、弹簧伸缩杆、挡板。本实用新型结构合理，通过CT扫描得到患者前臂残肢的数字模型，镜像得到残肢侧外形，提高假肢接受腔舒适性及假肢外观，通过旋转正反螺纹丝杠，使左夹具向右移动，同时右夹具向左移动，从而使左夹具和右夹具将螺栓夹紧固定，同时使假肢手与内外接受腔固定连接，通过旋转固定丝杠，使移动座和清洁结构向下移动，通过清洁结构可对透气孔部位进行清理同时对内外接受腔内部的汗水进行吸附，通过导热管将导热座内部的热量排入散热磷内部，再通过散热磷将热量由透气孔排出。

一种黑陶香薰器皿及其制备方法

Resumen de: CN120695233A

本发明公开了一种黑陶香薰器皿，包括有壶体主体、香薰托盘、内置陶芯模块，内置陶芯模块采用中空多孔陶块，可吸附精油或香料，可拆卸更换，壶体主体的内壁覆有高温相变陶瓷微球涂层，由以下重量份的原料组成：高岭土40-50％；黏土15-25％；长石5-8％；石英粉5-10％；硅藻土5-10％；负离子矿石粉2-5％；高温相变陶瓷微球1-3％；植物灰或碳粉1-2％。本发明壶体内壁采用高温相变陶瓷微球+透明陶瓷溶胶涂层，不仅提升陶器的热储存与热释放能力，还能稳定释放负离子，具有净化空气、增强香薰效能、缓释香气的功能，香薰壶配有可拆卸的中空多孔陶芯模块，模块结构具有良好吸附与透气性能，可反复使用或替换不同香型香料，用户体验佳、经济耐用。

PROSTHETIC DEVICES HAVING PRESSURE SENSORS AND METHOD OF THEIR USE

Resumen de: WO2025199404A1

A sensor device for use with a prosthetic socket includes a base material with at least one flexible printed circuit board (PCB) secured to the base material, the PCB having a plurality of pressure sensors. The PCB may include a radial arrangement of multiple PCBs or a single PCB with an integrated sensor array connected to a main processing unit via a flat ribbon cable. Comfort cell sensors with embedded BLE pressure sensors may also be used. The sensor device is positioned between a prosthetic silicone liner and socket to measure interface pressure. The data is processed to generate a real-time 3D pressure heatmap and may also be processed into 3D surface models using backend processing pipelines. Visualization software supports UV mapping, heuristic pressure analysis, and GPU-accelerated rendering, while a mobile application enables real-time interaction with the data for prosthetic fit evaluation.

3D PRINTED MATERIALS AND METHODS

Resumen de: WO2025198947A1

Aspects of the present disclosure generally relate to 3D printed scaffolds for attaching a radionuclide and methods of use thereof. In some embodiments, 3D printed scaffolds comprising a first layer and/or a second layer, and a radionuclide, are provided. In some embodiments, methods for capturing a radionuclide using said 3D printed scaffolds, are provided. In some embodiments, methods of using 3D printed scaffolds with a radionuclide to capture a daughter radionuclide product at a location different than the 3D printed scaffold, are provided.

ACOUSTIC FLUID-MEDIATED DEPOSITION-TYPE BIOPRINTING APPARATUS FOR ULTRAHIGH CELL DENSITY FUNCTIONAL ORGANS, AND PRINTING METHOD THEREFOR

Resumen de: WO2025194540A1

Disclosed are an acoustic fluid-mediated, deposition-type bioprinting apparatus for ultrahigh cell density functional organs, and a printing method therefor, belonging to the technical field of medical engineering manufacturing. The apparatus comprises an array surface acoustic wave chip, a printing container, a printing platform and a curing light source; the printing container is used to hold a printing ink; the printing platform is horizontally placed inside the printing container, and can move up and down in the printing ink; the array surface acoustic wave chip and the curing light source are both located above the printing container; the array surface acoustic wave chip comprises multiple interdigitated electrodes arranged in a ring shape in the same horizontal plane; the central axis of each interdigitated electrode deviates from a direction facing the center of the ring; the array surface acoustic wave chip contacts the printing ink, and can form a focused acoustic flow in the printing ink between it and the printing platform, aggregating cells in the printing ink; the curing light source can project into the printing ink above the printing platform, and cure the printing ink. The present invention has advantages such as rapid printing and adjustable cell concentration.

口腔インプラント材料の製造方法

Resumen de: JP2025138476A

【課題】口腔インプラント材料の製造方法を提供する。【解決手段】複数の標準金属インゴットに金属材料を使用して歯根部を印刷して、金属基盤を得て、金属基盤の周囲に歯槽修復材料５を印刷し、選択的レーザー溶解プロセスが歯根部の印刷に使用され、溶融堆積プロセスが歯槽修復材料の印刷に使用される。本発明は、１回の印刷で複数の患者用のインプラント材料を同時に製造する。【選択図】図５

OBLIQUE-INCIDENT-BODY-WAVE-ASSISTED ULTRA-HIGH-CELL-DENSITY MULTICELLULAR TISSUE LIFTING BIOPRINTING DEVICE AND PRINTING METHOD THEREFOR

Resumen de: WO2025194541A1

The present invention relates to the technical field of medical manufacturing. Disclosed are an oblique-incident-body-wave- assisted ultra-high-cell-density multicellular tissue lifting bioprinting device and a printing method therefor, the bioprinting device comprising a printing liquid tank, a printing platform, a light source and an oblique incident body wave chip, wherein the printing liquid tank contains a printing liquid which is a mixture of cells and a photocurable bio-ink; the printing platform is arranged horizontally and extends into the printing liquid tank to come into contact with the printing liquid; the printing platform can be raised or lowered; the light source is arranged below the printing liquid tank, and light is incident into the printing liquid tank; the oblique incident body wave chip is a piezoelectric transducer arranged obliquely; and the piezoelectric transducer is arranged below the printing liquid tank and tilted relative to a horizontal plane so as to generate an oblique incident body wave acoustic field in the printing liquid. The present invention can realize large-volume three-dimensional printing of a biomimetic tissue model with an ultra-high-cell-density and multicellular structure, and has the advantages of being ultra fast, having a large volume, and having an adjustable cell concentration and a simple liquid-exchange structure.

STRUT STRUCTURE

Resumen de: WO2025194222A1

An expandable strut lattice structure for a structural component, the structure comprising extendable struts.

3D PRINTING TRANSPARENT BIOINK FORMULATION

Resumen de: US2025295837A1

Bioink comprising modified fibers of MFC with a diameter of about 100-400 nm.

RADIATION-CURABLE COMPOSITION FOR USE IN A RAPID PROTOTYPING PROCESS OR A RAPID MANUFACTURING PROCESS

Resumen de: US2025297044A1

Polymerizable, radiation-curable compositions are provided and comprise (i) monomers and (ii) at least one further component, wherein the (i) monomers comprise (a) at least one urethane (meth)acrylate that is at least difunctional, (b) at least one monofunctional acrylate having an alicyclic group and/or at least one monofunctional methacrylate having an alicyclic group, and (ii) the at least one further component comprises (c) at least one photoinitiator for the UV and/or visible range or a photoinitiator system for the UV and/or visible range. The compositions are usable for producing, via a rapid prototyping, manufacturing, or tooling process, dental prosthetic parts, orthopaedic instruments, or dental pre-forms that have a flexural strength of greater than or equal to 75 MPa, a modulus of elasticity of greater than or equal to 2600 MPa, and/or a water absorption of less than 45 μg/mm3.

SURGICAL CLAMP

Resumen de: AU2024235637A1

A surgical clamp for providing a stable mechanical grasp and stabilisation of bone during an orthopaedic surgical procedure, comprising: a first arm comprising: an extended section comprising a mount at the distal end thereof; and a first jaw portion located at the distal end of the first arm; a second arm comprising: a fastening platform located at the proximal end of the second arm; and a second jaw portion located at the distal end of the second arm; engagement means comprising a bolt to engage the first arm with the second arm about a pivot point formed by the engagement means to provide relative rotation of the first and second arms between: an open configuration whereby first jaw portion and second jaw portion are urged apart; and a clamped configuration whereby first jaw portion and second jaw portion are urged into clamping engagement with the patient's bone in use during the surgical procedure; a fastening component comprising a fastening bolt and a fastening nut, adapted to engage the first and second arm into a locked clamped configuration about the bone of a patient during the surgical procedure; and a handle adapted to be gripped by a surgical assistance for stabilisation of the patient's joint or bone during the surgical procedure.

Impact Resistant Material

Resumen de: US2025297834A1

The current disclosure is directed to an impact resistant material made from a novel melanin composite. It has been found that using these composites allows for the production of effective ballistic protection and blast containment materials.

MULTI-VALENT POLYMERIZABLE COMPOSITIONS AND METHODS OF PRODUCING AND USING THE SAME

Resumen de: US2025297052A1

The present disclosure provides photo-polymerizable components, photo-curable resins comprising one or more of such monomers, as well as polymeric materials formed from the photo-curable resins. Further provided herein are methods of producing the compositions and using the same for the fabrication of medical devices, such as orthodontic appliances.

COLLAGEN-CONTAINING CURABLE FORMULATIONS

Resumen de: US2025295791A1

A conjugate made of collagen and a plurality of curable elastic moieties covalently attached thereto, a curable formulation (e.g., a bioink composition) that comprises the conjugate and additive manufacturing of a three-dimensional object which utilizes the curable formulation are provided. Also provided are methods/processes of additive manufacturing that employ collagen that feature a plurality of photocurable groups, in which the viscosity of a collagen-containing formulation is determined by manipulating an amount of the photoinitiator that is mixed with the collagen.

CHAOTIC PRINTING FOR THE PRODUCTION OF NON-FILAMENTOUS ARCHITECTURES

Resumen de: US2025296278A1

Disclosed are methods for preparing non-filamentous scaffolds (e.g., sheets) for cell or tissue culture. These methods can comprise providing at least a first printing composition (e.g., a bioink) and a second printing composition (e.g., a bioink or a fugitive ink); chaotic printing the first printing composition and the second printing composition to generate a microstructured precursor comprising a plurality of lamellar structures formed from the first printing composition and the second printing composition; extruding the microstructured precursor through a nozzle (e.g., a fan-shaped nozzle, a curved fan-shaped nozzle, or an annular nozzle) to produce a non-filamentous microstructured precursor; and curing the non-filamentous microstructured precursor to provide the non-filamentous scaffold for cell or tissue culture.

FUNCTIONALLY-DIVIDABLE ORODISPERSIVE DOSAGE FORM

Resumen de: US2025295593A1

A dividable tablet with a functional seam for functionally dividing the dividable tablet into substantially equivalent sub-dosage units along the functional seam. The functional seam is configured to subdivide the sub-dosage units into the same mass within a tolerance of about 3% or less, and typically of 1.0% or less. The functional seam is configured reduce the amount of lost material that separates from the divided sub-dosage units after division of the dividable tablet along the functional seam, to less than 3%, and typically less than 1.0%, and more typically less than 0.1% of the mass of the undivided dividable tablet.

ADJUSTABLE BRACE AND PROCESSES FOR MAKING AND USING SAME

Resumen de: US2025295513A1

An adjustable brace for stabilizing a body part of a patient and a method of fabricating such a brace is provided. In some embodiments, the adjustable brace comprises a first stabilizer having a first exterior surface, a first interior surface, a first thickness, and a plurality of first stabilizer guides; a second stabilizer comprising a second exterior surface, a second interior surface, a second thickness, and a plurality of second stabilizer guides; and at least one flexible lacing member extending along the first and second stabilizer guides, wherein the flexible lacing member adjustably secures the first stabilizer to the second stabilizer. Additional embodiments further include a closure mechanism to assist in the flexible lacing member adjustment.

3D PRINTED MATERIALS AND METHODS

Resumen de: US2025295839A1

Aspects of the present disclosure generally relate to 3D printed scaffolds for attaching a radionuclide and methods of use thereof. In some embodiments, 3D printed scaffolds comprising a first layer and/or a second layer, and a radionuclide, are provided. In some embodiments, methods for capturing a radionuclide using said 3D printed scaffolds, are provided. In some embodiments, methods of using 3D printed scaffolds with a radionuclide to capture a daughter radionuclide product at a location different than the 3D printed scaffold, are provided.

EQUINE NASOGASTRIC TUBE MODEL AND RELATED METHODS

Resumen de: US2025299602A1

Systems and associated method of fabrication of anatomically accurate animal training models can comprise fabricating at least one inverse anatomical feature representative of an anatomical feature in an animal's head, forming a mold of the animal's head, connecting the at least one inverse anatomical feature in the mold of the animal's head, filling the mold of the animal's head with a filling material, and removing the cast head from the mold.

CERAMIC PROCESSING FOR THE DIRECT MANUFACTURE OF CUSTOMIZED LABIAL AND LINGUAL ORTHODONTIC BRACKETS

Resumen de: US2025298391A1

A method of manufacturing customized ceramic labial/lingual orthodontic brackets by digital light processing, said method comprises measuring dentition data of a profile of teeth of a patient, wherein measuring dentition data is performed using a CT scanner or intra-oral scanner, based on the dentition data, creating a three dimensional computer-assisted design (3D CAD) model of the patient's teeth using reverse engineering, and saving the 3D CAD model on a computer, designing a 3D CAD bracket structure model for a single labial or lingual bracket structure, importing the 3D CAD bracket structure model into a Digital Light Processing (DLP) machine, directly producing the bracket by layer manufacturing.

ACOUSTIC FLUID-MEDIATED BOTTOM-UP BIOPRINTING DEVICE FOR FUNCTIONAL ORGANS WITH ULTRAHIGH CELL DENSITY AND PRINTING METHOD THEREFOR

Resumen de: US2025297202A1

An acoustic fluid-mediated bottom-up bioprinting device for functional organs with an ultrahigh cell density and a printing method are provided, the acoustic fluid-mediated bottom-up bioprinting device includes an array SAW chip, a printing container, a printing platform and a curing light source; the printing container is used for containing a printing ink; the printing platform is able to move upward and downward in the printing ink; the array SAW chip includes a plurality of interdigital electrodes; a central axis of each interdigital electrode deflects from a direction towards a center of the circle; the array SAW chip is in contact with the printing ink and is able to form a focused acoustic flow to aggregate the cells in the printing ink; the curing light source is able to expose a projection into the printing ink above the printing platform and cure the printing ink above the printing platform.

APPARATUS FOR PRODUCING TABLETS

Resumen de: WO2025195853A1

The invention relates to an apparatus (1) for producing tablets (2), wherein the apparatus (1) comprises a precursor material production device (3) and an additive manufacturing device (4), wherein the precursor material production device (3) is designed to coat granulate particles (6) containing a medicament (5) with a coating agent (8) comprising a thermoplastic material (7) in order to produce precursor material particles (9), and wherein the additive manufacturing device (4) is designed to produce tablets (2) from a powdered precursor material (10) comprising a plurality of precursor material particles (9) by selective laser sintering.

FUNCTIONALLY-DIVIDABLE ORODISPERSIVE DOSAGE FORM

Resumen de: WO2024108084A1

A dividable tablet with a functional seam for functionally dividing the dividable tablet into substantially equivalent sub-dosage units along the functional seam. The functional seam is configured to subdivide the sub-dosage units into the same mass within a tolerance of about 3% or less, and typically of 1.0% or less. The functional seam is configured reduce the amount of lost material that separates from the divided sub-dosage units after divi sion of the dividable tablet along the functional seam, to less than 3%, and typically less than 1.0%, and more typically less than 0.1% of the mass of the undivided dividable tablet.

Medical device based on bioceramics, its use as a synthetic bone graft and process for the preparation thereof

Resumen de: GB2639318A

The present invention relates to a medical device manufactured using the additive manufacturing process (3D printing). It is a medical device used preferably as a bone graft composed of a porous structure based on bioceramics based on β-tricalcium phosphate (β-TCP) or hydroxyapatite, which may or not contain nanostructures in its composition, for example: carbon nanostructures (graphene, graphene oxide, reduced graphene oxide, carbon nanotubes, etc.) and, in preferred embodiments, stem cells and polymeric membrane. Also, the present invention relates to the use of this device as a bone graft and the process of preparing this device.

ASSEMBLY FOR CARRYING A DENTAL PROSTHESIS AND A METHOD OF MANUFACTURING THE SAME

Resumen de: WO2024104515A1

The object of the invention is an assembly for carrying a dental prosthesis and a method of manufacturing the same, wherein the assembly for carrying a dental prosthesis comprises a dental implant (1 ), a fixation screw (2), and a pillar (3) for fixing the dental prosthesis, where the pillar (3) comprises a first end (4) of the pillar, a second end (5) of the pillar opposite the first end (4) of the pillar, and a cavity (6) of the pillar, wherein the cavity (6) of the pillar opens at both the first and second ends (4,5) of the pillar and the first end (4) of the pillar is adjacent to the dental implant (1 ), wherein at least a part of the fixation screw (2) is located in the cavity (6) of the pillar and the fixation screw (2) is connected to the dental implant (1 ), wherein the cavity (6) of the pillar comprises a first side (7) of the cavity comprising a first section (8) of the cavity and a second side (9) of the cavity comprising a second section (10) of the cavity, wherein the first side (7) of the cavity is located closer to the first end (4) of the pillar than the second side (9) of the cavity and the cross-section of the first section (8) of the cavity is larger than the cross-section of the second section (10) of the cavity, wherein the fixation screw (2) comprises a head (11 ) of the fixation screw that is located in the first side (7) of the cavity.

可术中调整的椎弓根钉导板

Resumen de: CN223365636U

本实用新型属于医疗器械领域，涉及一种可术中调整的椎弓根钉导板，包括横跨棘突的导板本体，导板本体端部固设有用于与脊椎骨面贴合的定位板，导板本体上设置有与规划置钉方向平行的导向柱，定位板上与规划置钉点相对应的位置开设有导向槽。本实用新型通过半开放式的定位方式，使定位具备了一定的自由度和灵活度，术中可以进行二次调整和定位，提高了置钉的精准性，且便于术中导板的取出，同时节省了耗材成本，适用于椎弓根钉内固定术中椎弓根钉的定位。

用于下颌运动记录设备的个性化夹具

Resumen de: CN223365542U

本实用新型公开了一种用于下颌运动记录设备的个性化夹具，涉及牙科器械技术领域，包括：口内粘接装置，包括第一板体和第二板体，所述第一板体设置有两块，每块所述第一板体均呈弧形，且与相邻下槽牙牙面的弧度相适配，两块所述第一板体分别用于粘接在两侧的下槽牙唇侧，所述第二板体位于下颌牙的唇侧，且两块所述第一板体分别固定连接在所述第二板体的两侧，所述第二板体与下颌牙唇侧之间的间距大于等于上颌牙的厚度；固定器，用于安装下颌运动记录仪的下颌传感器。本申请的技术方案通过将第二板体与下颌牙唇侧之间的间距设置为大于等于上颌牙的厚度，可确保深覆颌受试者在使用该装置时上颌牙与下颌牙侧向运动期间不会产生干扰。

深层组织的体内打印

Resumen de: WO2024173885A1

Techniques for deep tissue in vivo printing are described. Some implementations of the disclosure relate to a method that includes: obtaining a biopolymer mixture including prepolymer material and a crosslinking agent encapsulated in carrier particles; delivering the biopolymer mixture to a subcutaneous or deep tissue target location of a subject; and transmitting with a bioprinting device, via transcutaneous application, radiation to the subcutaneous or deep tissue target location, the radiation configured to cause the carrier particles to release at least some of the crosslinking agent, the released crosslinking agent configured to cause the prepolymer material to form into a gel or polymeric matrix.

一种用于分阶段骨再生的3D生物打印径向多孔支架及其制备方法

Resumen de: CN120678997A

本发明公开了一种用于分阶段骨再生的3D生物打印径向多孔支架及其制备方法，所述3D生物打印径向多孔支架可以提供仿生细胞微环境，以支持宿主修复细胞向缺损部位的渗透，并在植入后促进骨整合，此外，所述3D生物打印径向多孔支架中含有的双重生长因子的序贯释放和后期PO43‑和Ca2+的持续释放可以完成分阶段骨再生的三个关键步骤，能够实现高效骨再生，代表了一种有前景的仿生阶段性再生策略。

一种基于FDM多材料3D打印的微电流面膜及其制备方法

Resumen de: CN120678663A

本发明公开一种基于FDM多材料3D打印的微电流面膜及其制备方法，所述微电流面膜包括薄膜电池层、支撑层、活性成分层和吸附层，通过采用多层叠覆式结构设计，各层之间相互配合，由内而外依次设置，各层面积按照面部的弧度和轮廓逐渐递减，通过正金字塔型逐级递减的面积设计增强微电流面膜的贴合度，根据面部轮廓更好地贴合皮肤，减少对面部的拉扯和不适感。所述微电流面膜的制备方法，基于用户面部扫描数据，并通过多维特征融合分析，将获取的数据进行整合分析，使得建立的三维模型更为自然和贴切用户的实际面部，实现精确定制微电流面膜，提高微电流面膜的贴合度和舒适性；同时采用了FDM多材料3D打印技术，支持多材料的精确组合和功能集成，增强微电流面膜的功效性和安全性。

一种仿生甲虫骨架植入物的制备方法

Resumen de: CN120680013A

本发明公开了一种仿生甲虫骨架植入物的制备方法，属于股骨植入领域。本发明创新性地将甲虫鞘翅和角质层的仿生结构特征相结合，通过仿生结构设计的方法有效提升了多孔镍钛合金结构植入体的力学强度和结构稳定性，成功解决了传统股骨金属植入物长期存在的应力屏蔽效应问题，采用选择性激光熔化（SLM）技术制备出的多孔镍钛合金仿生骨架结构，其不仅具有良好的力学适配性，避免了植入后与自然骨组织的排斥脱落反应，还能在室温环境下实现完全的形状记忆恢复功能，在医用骨科植入领域具备良好的应用前景。

用于3D打印的金属粉末

Resumen de: US2024123495A1

A method of using a metal powder in an additive manufacturing process. The method includes providing the metal powder, and using the metal powder in the additive manufacturing process. The metal powder is a metal which is selected from tantalum and impurities, titanium and impurities, niobium and impurities, an alloy of tantalum, niobium and impurities, an alloy of titanium, niobium and impurities, and an alloy of tantalum, titanium, niobium and impurities. Particles of the metal powder have a dendritic microstructure. Particles of the metal powder have an average aspect ratio ΨA of from 0.7 to 1, where ΨA=XFeret min/XFeret max.

医用组织包裹物

Resumen de: AU2023370241A1

The invention relates to the field of medical tissue wraps for internal anatomical structures as well as a use and a method of treating a nerve lesion using such medical tissue wraps. In particular, the invention relates to medical tissue wraps for neural tissue supporting the repair of peripheral nerve lesions by facilitating secure application of the medical tissue wrap. Accordingly, a medical tissue wrap (10) for an internal anatomical structure of a mammal is suggested, wherein the medical tissue wrap (10) is formed by a coiled wall (12) having a circumferential inner end portion (20) and a circumferential outer end portion (22) extending around and overlapping the circumferential inner end portion (20). The wall (12) thereby defines a longitudinal through-hole (16) for accommodating a portion of the anatomical structure. According to one aspect of the invention, the circumferential outer end portion (22) is radially spaced-apart from the circumferential inner end portion (20) by a discontinuous spacing in the circumferential direction. According to a further aspect, the tissue wrap comprises a structural outer surface modification at opposing longitudinal end portions of its wall.

全口义齿及全流程数字化的全口义齿制作方法

Resumen de: CN120678548A

本发明公开全口义齿及全流程数字化的全口义齿制作方法。本发明以光学印模替代传统印模，电子运动面弓+下颌运动轨迹描记替代机械面弓+哥特式弓描记，结合语音法显示的下颌轨迹特征，替代传统的颌位记录，技术敏感性更低，颌位关系记录更精准，在口扫后过软件预排牙和电子面弓直接生成咬合方案，省去蜡型试戴、传统的颌位记录等中间步骤，且本申请采用数字化制造减少手工操作，三维打印/切削技术直接输出义齿，省去装盒、煮牙、打磨等繁琐工序，制作周期大大缩短，往后二次复制或再制作时间及适应时间大大等缩短，并为全口种植咬合重建颌位提供数字化解决方案，更利于数智数据的开发、整合等。

使用三维模型制造物体的方法和系统

Resumen de: CN120680723A

本申请涉及一种三维模型制造物体的方法和系统。上述方法包括：获取多个待打印的三维模型，三维模型包括模型关联信息，根据模型关联信息将各三维模型存储至一个或多个存储单元中，从指定存储单元中自动抓取至少一个目标三维模型，对目标三维模型进行排版处理，得到排版结果，基于排版结果，对目标三维模型进行三维打印。采用本方法能够能够在三维模型文件设计完成后，分类存储，自动抓取数据，自动完成前处理，并自动下发至三维打印设备进行三维打印，全程无需人工任何操作，提高三维模型的打印效率。

一种氧化锌-氧化铝陶瓷骨修复支架的制备方法

Resumen de: CN120682021A

本发明涉及生物医学材料的技术领域，公开了一种氧化锌‑氧化铝陶瓷骨修复支架的制备方法；首先按照比例称取氧化铝造粒粉和酚醛树脂粉体，混合氧化铝造粒粉和酚醛树脂粉体，得到获得3D打印复合粉体；其次，将3D打印复合粉体通过选择性激光烧结设备，制备得到氧化铝陶瓷坯体；将氧化铝陶瓷坯体进行干燥，得到干燥后的陶瓷坯体，并将干燥后的陶瓷坯体进行脱脂和烧结处理，冷却得到氧化铝预成型体；最后，使用纳米氧化锌溶胶对所述氧化铝预成型体进行真空压力浸渗，并引入动麦优化算法对真空压力浸渗参数进行优化，得到氧化锌‑氧化铝陶瓷骨修复支架；本发明通过制备工艺和智能优化工艺参数得到氧化锌‑氧化铝陶瓷骨修复支架，方法客观准确。

一种种植基台的牙冠批量打印装置及方法

Resumen de: CN120680724A

本发明提供了一种种植基台的牙冠批量打印装置及方法包括：利用牙龈形态数据库对患者牙龈采样数据进行深度优化，确定患者的基台排布特征并确定所述患者的基台打印数据，根据所述患者的已提需求和所述基台排布特征创建所述患者的若干种牙冠形态，并构建每一所述牙冠形态对应的牙冠打印数据，根据所述患者的面部数据分别模拟每一所述牙冠打印数据对应的打印效果，根据指令选取目标牙冠打印数据，根据所述基台打印数据和所述目标牙冠打印数据分别打印所述患者的基台和牙冠，根据患者的需求和实际取模结果自动调整打印设备的激光功率和打印预备工作，可以实现牙冠和基台的批量打印或个性化打印，提高了打印的效率，确保了打印成品的质量。

열성형 모델을 고정하기 위한 기술

Resumen de: MX2025006175A

The present disclosure discusses techniques for securing thermoform models, including a locator plate (1105, 601, 701) for receiving and securing individually unique dental models having a raised polygon cutout (502) together with a locator pin (603, 802), a system for thermoforming an orthodontic aligner, and methods thereof.

一种用于葡萄糖响应性DLP 3D打印胶原蛋白生物墨水、制备方法及应用

Resumen de: CN120678985A

本发明属于生物医用材料技术领域，具体涉及一种用于葡萄糖响应性DLP 3D打印胶原蛋白生物墨水、制备方法及应用。本发明提供了一种葡萄糖响应性DLP 3D打印胶原蛋白生物墨水；所述生物墨水在pH 7的生理条件下可制备具有良好的机械性能、保真度和抗降解能力的水凝胶；且该凝胶可在高血糖环境下进行响应性释放；释放的姜黄素可以清除细胞内ROS，调控巨噬细胞炎症因子表达，发挥抗氧化抗炎功效，并且凝胶材料还能够促进细胞的增殖、黏附、迁移，具有良好的生物相容性和生物活性；在为糖尿病创面治疗提供了兼具智能释药、力学适配与主动促愈功能的个性化解决方案。

3D FILAMENT FOR 3D PRINTER COMPRISING ACETAMINOPHEN AND IBUPROFEN AND DUAL RELEASE FORMULATION AND METHOD OF PREPARING THE SAME

Resumen de: KR20250138511A

본 발명은 속방출 필라멘트층 내부에 분포된 서방출 과립층을 포함하고, 상기 서방출 과립층은 아세트아미노펜(acetaminophen) 또는 이의 약학적으로 허용가능한 염 및 제1 고분자를 포함하고, 상기 속방출 필라멘트층은 이부프로펜(ibuprofen) 또는 이의 약학적으로 허용가능한 염 및 제2 고분자를 포함하며, 상기 제1 고분자는 상기 제2 고분자 보다 유리전이온도가 높은 것을 특징으로 하는 3D 프린터용 필라멘트, 이를 이용한 이중방출 제형 및 제조방법에 관한 것이다.

一种梯度致密度金属植入物增材制造方法

Resumen de: CN120662830A

本发明提供了一种梯度致密度金属植入物增材制造方法，涉及激光选区熔化增材制造技术领域，该方法通过多模态传感器融合与自适应控制算法，实现金属植入物从外层到内层的连续梯度致密度分布，精确模拟骨骼的生物力学特性，从而省去设计多孔结构的步骤；可精确模拟人体骨骼的皮质骨(高致密)与松质骨(多孔)结构，提升植入物的生物力学适配性。

ARTIFICIAL PROSTHESIS WITH SURFACE ROUGHNESS

Resumen de: KR20250137767A

별도의 쉘을 포함하지 않는 인공 보형물로서, 생분해성 고분자를 포함하고, 상기 인공 보형물의 외부 표면은 최대 높이 거칠기 값(Rmax)이 3~45μm이고, 상기 인공 보형물의 외부 표면은 10점 평균 거칠기 값(Rz)이 3~45μm인, 인공 보형물이 제공된다.

バイオプリントされた軟組織補強足場

Resumen de: CN119968177A

The present disclosure encompasses systems, compositions, and methods for use in vivo, including for enhancing soft tissue in an individual. The systems, compositions, and methods may utilize a three-dimensionally printed scaffold comprising at least a polymeric scaffold and an extracellular matrix component, including an extracellular matrix component contained on the scaffold. The polymer scaffold may include specific unit cell structures having a specific design and a pattern of alternating configurations of unit cell structures.

볼 플런저를 사용하여 모델을 고정하기 위한 기술

Resumen de: MX2025006182A

The present disclosure discusses techniques for securing thermoform models, including a locator plate for receiving and securing individually unique dental models having a polygon cutout, wherein the locator plate has at least one ball plunger (108) positioned within a raised polygon (102), the at least one ball plunger having a cylindrical body, a spring, and a ball extending partially outside the cylindrical body. The present disclosure also includes a system for thermoforming an orthodontic aligner and methods thereof.

一种基于3D打印的可降解鼻大翼软骨支架及其制备方法

Resumen de: CN120661739A

本发明公开了一种基于3D打印的可降解鼻大翼软骨支架及其制备方法，支架由PLGA以及纳米羟基磷灰石复合基体、载药微球及梯度多孔仿生结构组成，表面覆盖壳聚糖涂层以增强细胞黏附性。通过调控PLGA分子量和羟基磷灰石含量实现降解速率与软骨再生速率匹配。支架内部嵌入载有地塞米松与TGF‑β的微球。制备方法结合熔融沉积3D多喷头协同打印技术与患者CT/MRI数据建模。相较于传统不可降解材料及现有可降解支架，本发明兼具力学适应性、降解可控性、药物功能集成化及临床适配性优势，适用于先天性鼻畸形、外伤性缺损修复及联合自体软骨移植治疗，有效解决了现有材料生物相容性差、降解速率失配及通用性不足等问题。

光固化生物墨水、数字光处理3D打印产品及其制备方法和在制备颅骨修复材料中的应用

Resumen de: CN120661738A

本发明提供了光固化生物墨水、数字光处理3D打印产品及其制备方法和在制备颅骨修复材料中的应用，属于生物医药技术领域。本发明提供的材料能够在不同环境条件下持续地释放H₂O₂。尤其是在模拟体内环境中，GHDP水凝胶在较长时间内保持稳定的H₂O₂释放，从而不断激活血管生成相关的信号通路，在颅骨缺损修复过程中，能够通过调控H₂O₂水平，促进新生血管形成和成骨分化，为利用氧化还原信号调控来促进组织再生提供了新的策略与思路。

一种3D打印构建骨肿瘤修复的压电骨支架的制备方法

Resumen de: CN120661733A

本发明公开了一种3D打印构建骨肿瘤修复的压电骨支架的制备方法，属于生物医用材料领域。所述方法通过3D打印构建骨肿瘤治疗修复的压电骨支架材料，具体包括以下步骤：均匀混合固定体积比的钛酸钡(BTO)和羟基磷灰石(HA)，通过光固化树脂，打印具有特定孔隙结构的生胚，随后经过脱脂、烧结、极化和后处理，制得BTO/HA压电复合骨支架。本发明制备得到的压电复合骨支架具有与骨缺损部位高度匹配的精确形状，同时可通过压电效应催化产生活性氧自由基，实现残留骨肿瘤细胞的高效原位灭活，将骨肿瘤治疗(压电抗肿瘤)和骨缺损修复(HA促骨化)两大功能集成于一体，提升治疗修复效果，改善患者的生活质量。

一种光固化3D打印含碳导电多孔材料及其制备方法及应用

Resumen de: CN120665428A

本发明涉及一种光固化3D打印含碳导电多孔材料及其制备方法及应用。该方法基于巯基‑烯点击化学与聚合诱导相分离原理，通过将含巯基低聚物、含烯基低聚物、导电碳材料及致孔剂复配为低粘度墨水，通过对墨水聚合反应动力学和流变性质研究，结合光固化3D打印技术一步成型多尺度多孔结构。所述致孔剂兼具溶剂功能，降低墨水粘度并诱导微观孔隙生成，与宏观模型设计结合，形成多级孔隙网络。所得材料在智能传感、电磁屏蔽及水处理等领域展现出潜在应用价值。

FUNCTIONALIZED AND CROSSLINKED POLYMERS

Resumen de: US2025289909A1

Polyhydric polymers may be converted to derivatives thereof by reaction with divinyl sulfone to provide vinyl sulfone substituted polymers, where the polymers may additionally be further derivatized, including crosslinked, and the crosslinked and non-crosslinked derivatives may be used in biomedical and other applications.

3D PRINTED COMPOSITES FROM PHASE SEPARATED MATERIALS

Resumen de: US2025289919A1

The present disclosure provides methods, systems, devices, and kits for creating composite materials from a single resin, the composite materials having multiple continuous phases. The disclosure includes a process to three-dimensionally print objects (e.g., orthodontic appliances) with composite properties. In some aspects, the composite properties are formed from a single formulation with components that, when processed, have hard and soft continuous phases. In some aspects, the composite properties are formed by separately processing the hard phase components and the soft phase components. In some aspects, the composite materials and devices are three-dimensionally printed using the processed material.

MULTI-VALENT POLYMERIZABLE COMPOSITIONS AND METHODS OF PRODUCING AND USING THE SAME

Resumen de: US2025289921A1

The present disclosure provides photo-polymerizable components, photo-curable resins comprising one or more of such monomers, as well as polymeric materials formed from the photo-curable resins. Further provided herein are methods of producing the compositions and using the same for the fabrication of medical devices, such as orthodontic appliances.

SPRAYED MULTI ADSORBED-DROPLET REPOSING TECHNOLOGY (SMART)

Resumen de: US2025288524A1

Described are techniques, systems, and methods include those employing pneumatic, pressure assisted, extrusion-based 3D printing and emulsion evaporation, emulsion diffusion, nanoprecipitation, desolvation, gelation, spray-based atomization, etc. for fabricating loaded microparticles or nanoparticles that encapsulate an active pharmaceutical ingredient or live cells into a biocompatible polymer or pharmaceutical excipients. The techniques provide for encapsulation of a variety of substances including proteins, plasmid DNA, lipophilic pharmaceutical compositions, hydrophilic pharmaceutical compositions, live cells, and/or cellular components into polymeric microparticles or nanoparticles. The particles loaded with active pharmaceutical ingredients can be used for the treatment of different diseases or conditions. The particles loaded with live cells can be used for disease treatment, but can also be used for securely storing the live cells in a stable condition for transport and later use in inoculating fermentation systems, for example, to generate recombinant proteins.

IMPLANT SYSTEM AND METHOD FOR JOINT FUSION

Resumen de: US2025288331A1

Implant systems and methods treatment of a joint include a distal portion, a middle portion, and a proximal portion. The distal portion may include a thread having a first thread minor, a first thread major, and a first pitch. The distal portion also may have a reverse cut, helical fenestration formed through the thread. The middle portion may be devoid of threads and may include a porous outer surface structure to promote bony integration, the porous outer surface structure having a leading end and a trailing end, with the leading end having a diameter larger than the first thread minor. The proximal portion may include a proximal thread having a second thread minor, a second thread major, and a second pitch. The second thread minor may be substantially the same width as the trailing end of the middle portion.

Method and Apparatus for Cutting Three-dimensional Tooth Model

Resumen de: US2025288399A1

A method and apparatus for cutting a three-dimensional tooth model are provided. The method includes: obtaining a two-dimensional projection image of a three-dimensional tooth model, and recognizing the two-dimensional projection image to obtain a plurality of tooth regions, the tooth regions corresponding one to one to teeth; determining original seed points corresponding to the plurality of tooth regions in the three-dimensional tooth model; expanding the original seed points within a preset range to obtain target seed points of the teeth in the three-dimensional tooth model; and cutting the three-dimensional tooth model based on the target seed points of the teeth to obtain cut teeth.

3D PRINTED STRUCTURALLY SOUND PROSTHETIC SOCKET

Resumen de: US2025288423A1

A method for 3D printing a prosthetic socket from a digital model, including printing a solid wall perimeter of the prosthetic socket with a width achieved in a single pass of a printing nozzle, and forming a plurality of stiffener elements proximate a bottom end of the prosthetic socket, as a function of the printing the solid wall perimeter, is provided. Also provided is a 3D printed prosthetic socket including an upper portion, a lower portion configured to be attached to a prosthetic pylon, and a plurality of stiffener elements radially extending from the lower portion, wherein the upper portion, the lower portion, and the plurality of stiffener elements are printed as a solid wall construction comprised of a printing material deposited using only a single pass of a printing nozzle.

SACROPELVIC FUSION IMPLANT SYSTEM FOR PROVIDING A FOUNDATION FOR SPINOPELVIC FIXATION CONSTRUCTS IN ADULT SPINAL DEFORMITY SURGERY

Resumen de: US2025288424A1

A method of surgically treating a patient suffering from severe pain and disability of the low back and buttock by stabilizing the patient's spinal column to their pelvis with an implant system including surgical tools and an implant designed to prevent movement between the sacrum and the ilium while being able to attach to a spinal fusion rod which connect to pedicle screws implanted in the bones of the spine of the patient in order to offer lasting relief of the patient's symptoms. The system is designed to address complications in adult spinal deformity by optimizing spinopelvic fixation vis-à-vis the unique biomechanics of the SI joint. The sacropelvic system is a surgical solution which provides an additively manufactured implant at the base of the spine employing an S2AI trajectory while utilizing assisting technologies including surgical navigation and intraoperative neurophysiological monitoring.

BIOINK COMPOSITIONS COMPRISING THERMOSENSITIVE MICROPARTICLES AND USE THEREOF

Resumen de: WO2025191563A1

The present invention is directed to a method for 3D printing of cells attached to a cell scaffold by simultaneous printing of a first composition comprising thermoresponsive microparticles and a second composition comprising cells. Further provided a printed 3D object such as an implant, comprising cells attached to the cell scaffold of the invention.

UV POLYMERIZABLE ANTIMICROBIAL IMIDAZOLIDINYL UREA-BASED ACRYLATE RESIN FOR 3D PRINTING APPLICATIONS

Resumen de: WO2025191557A1

The present invention provides a polymeric chain made of acrylate-containing imidazolidinyl urea monomers and having antimicrobial properties, a UV polymerizable resin comprising said polymeric chain, and a product such as a medical device, obtained by 3D printing of said UV polymerizable resin.

CHAMBER WITH FLOW SYSTEM FOR BIOPRINTING AND CULTURING TISSUES MODELS

Resumen de: WO2025193110A1

The utility model relates to a chamber with a flow system for the bioprinting and culturing tissue models, containing: a chamber body (1 ) with a central opening obscured by a bottom glass (2), covered from the top by a cover (3) provided with a central opening obscured by a upper glass (5), whereby a silicone circular seal (4) is provided between the chamber body (1) and the chamber cover (3), wherein the chamber body (1) at its two opposite ends is provided with connectors (8) with connecting channels (10) providing a fluid connection to the working volume of the chamber defined by the inner walls of the chamber body (1 ) and the cover (3), the circular seal (4) and the inner surfaces of the bottom glass (2) and the upper glass (5) facing each other, where the flow system is formed by the connectors (8) with the connecting channels (10) and the working volume of the chamber contained between them; and an outer casing of the chamber comprising a bottom frame (6) and a top frame (7), wherein the chamber body (1) and the chamber cover (3), together with the elements contained between them, are enclosed between the bottom frame (6) and the top frame (7) of the outer casing, which are detachably connected to each other.

DEVICE FOR ESTIMATING THE THREE-DIMENSIONAL STRUCTURE OF TEETH

Resumen de: WO2025191493A1

Device for estimating the three-dimensional structure of teeth inside a mouth, comprising : - a central control unit, - a tray insertable inside the mouth, - a plurality of independent cameras arranged on the tray, each camera being equipped with a corresponding fixed focus lens, having a corresponding field of view and being designed to capture a corresponding image of the teeth within the field of view and to transmit the image to the central control unit, each image being composed by a plurality of pixels, and - illumination means arranged on the tray and designed to illuminate the fields of view of the cameras, wherein the central control unit is programmed to estimate the three-dimensional structure of the teeth by estimating independently for each image a depth value for each pixel thereof.

THREE-DIMENSIONAL PRINTING COMPOSITION COMPRISING METHACRYLATED CHITOSAN

Resumen de: WO2025193112A1

The invention relates to a three-dimensional printing composition comprising a dECM hydrogel-based biomaterial, a hydrogel made of methacrylated PBS biopolymer derivatives with a radical polymerisation photoinitiator, a methacrylated chitosan solution in 1% acetic acid, neutralised to a final concentration of 3.1 mg/ml in the biomaterial, and/or a chitosan solution in 2% acetic acid, neutralised to a final concentration of 1.4 mg/ml in the biomaterial.

Vorrichtung zur Herstellung von Tabletten

Resumen de: DE102024107712A1

Die Erfindung betrifft eine Vorrichtung (1) zur Herstellung von Tabletten (2), wobei die Vorrichtung (1) eine Vorläufermaterialherstellungseinrichtung (3) und eine additive Fertigungseinrichtung (4) aufweist, wobei die Vorläufermaterialherstellungseinrichtung (3) ausgebildet ist, um über einen Arzneistoff (5) verfügende Granulatpartikel (6) mit einem ein thermoplastisches Material (7) aufweisenden Beschichtungsmittel (8) zu beschichten, um Vorläufermaterialpartikel (9) zu erzeugen, und wobei die additive Fertigungseinrichtung (4) ausgebildet ist, um aus einem über eine Vielzahl von Vorläufermaterialpartikeln (9) verfügenden pulverförmigen Vorläufermaterial (10) durch selektives Lasersintern Tabletten (2) herzustellen.

Verfahren zur Herstellung von Tabletten

Resumen de: DE102024107710A1

Die Erfindung betrifft ein Verfahren zur Herstellung von Tabletten (2), wobei dass das Verfahren einen Beschichtungsschritt und einen auf den Beschichtungsschritt folgenden additiven Fertigungsschritt aufweist, wobei im Beschichtungsschritt über einen Arzneistoff (5) verfügende Granulatpartikel (6) mit einem ein thermoplastisches Material (7) aufweisenden Beschichtungsmittel (8) beschichtet werden, um Vorläufermaterialpartikel (9) zu erzeugen und im additiven Fertigungsschritt ein selektives Lasersintern eines über eine Vielzahl von Vorläufermaterialpartikeln (9) verfügenden pulverförmigen Vorläufermaterials (10) zu Tabletten (2) durchgeführt wird.

COLLAPSIBLE INNER FLOW CONTROL COMPONENT FOR SIDE-DELIVERABLE TRANSCATHETER HEART VALVE PROSTHESIS

Resumen de: EP4617061A2

A side-deliverable prosthetic heart valve includes an outer frame and a flow control component. The outer frame defines a central channel that extends along a central axis. The flow control component is disposed within the central channel and coupled to the outer frame. The flow control component has a set of leaflets mounted within an inner frame. The prosthetic valve is configured to be folded along a longitudinal axis and compressed along the central axis to place the prosthetic valve in a compressed configuration for delivery via a delivery catheter. The longitudinal axis is substantially parallel to a lengthwise axis of the delivery catheter when disposed therein. The prosthetic valve transitions to an expanded configuration when released from the delivery catheter. The flow control component elastically deforms from a substantially cylindrical configuration to a substantially flattened configuration when the prosthetic valve is placed in the compressed configuration.

LOAD-CARRYING ROD

Resumen de: WO2024100147A1

A load-carrying rod (1) for an implant system has a structure of individual interconnected solidified droplets (4) so that the transitions from one droplet to another act as crack stoppers in the event of a crack.

複合生体材料

Resumen de: MX2021013857A

Provided herein are composite scaffold biomaterials including two or more scaffold biomaterial subunits, each including a decellularized plant or fungal tissue from which cellular materials and nucleic acids of the tissue are removed, the decellularized plant or fungal tissue having a 3-dimensional porous structure, the two or more scaffold biomaterial subunits being assembled into the composite scaffold biomaterial and held together via gel casting using a hydrogel glue; via complementary interlocking geometry of the two or more scaffold biomaterial subunits; via guided assembly based biolithography (GAB); via chemical cross-linking; or any combinations thereof. Methods for producing such scaffold biomaterials, as well as methods and uses thereof, are also provided.

DYNAMIC HYDROGEL COMPOSITIONS

Resumen de: AU2023375461A1

Compositions and methods for delivery of therapeutic agents to an individual in need thereof, for prevention/reduction of tissue adhesion, and for 3D printing are disclosed herein. In some embodiments, the composition comprises octadecyl modified hydroxypropyl methylcellulose (HPMC-C18) and a surfactant or cyclic polysaccharide, wherein the composition is a hydrogel that exhibits dynamic properties.

A DETACHABLE PRINTHEAD FOR A BIOPRINTER AND A BIOPRINTER

Resumen de: AU2023377822A1

A detachable printhead for a bioprinter is disclosed, the detachable printhead comprising a body, removably attachable to a fixed portion of the bioprinter; a dispensing system, supported by the body; one or more reservoirs, for holding one or more biomaterials, in fluid communication with the dispensing system, supported by the body; and a coupling for attaching to the fixed portion of the bioprinter, the coupling including an interface for operating the dispensing system.

三维光造型用固化性组合物及其制造方法、三维光造型物的制造方法以及牙科用修复物的制造方法

Resumen de: AU2024218051A1

The present invention provides a curable composition for three-dimensional stereolithography, the curable composition being used in a vat photopolymerization method and containing 100 parts by mass of a polymerizable monomer component (A), 40 parts by mass to 400 parts by mass of an inorganic filler (B) that is composed of a single kind or plural kinds of inorganic particulate matter, and 0.01 part by mass to 5 parts by mass of a photopolymerization initiator (C), wherein: 80% or more of all primary particles that constitute the inorganic filler (B) have a particle diameter of 0.05 µm to 5.0 µm; and a sample, which is formed of this curable composition for three-dimensional stereolithography and has a thickness of 0.5 mm, has a transmittance of 1.00% to 50.00% with respect to activation light. The present invention also provides a method for producing this curable composition for three-dimensional stereolithography. The present invention also provides a method for producing a three-dimensional stereolithographic model and a method for producing a dental restoration, each using this curable composition for three-dimensional stereolithography.

光造型用树脂组合物

Resumen de: US2022371264A1

The present invention provides a resin composition for stereolithography that enables easy stereolithographical fabrication; and that can produce a cured object having desirable strain recovery, desirable toughness, and desirable water resistance. The present invention relates to a resin composition for stereolithography comprising a polymerizable compound (A) whose homopolymer has a glass transition temperature (Tg) of 37° C. or higher; and a photopolymerization initiator (B), and having a tan δ at 37° C. of 0.3 or less after cure.

一种3D打印生物墨水及其制备方法和应用

Resumen de: CN120643748A

本发明提供一种3D打印生物墨水及其制备方法和应用。所述3D打印生物墨水包括如下组分：甲基丙烯酸酐化明胶、氧化透明质酸、羧甲基壳聚糖和2‑甲基丙烯酰氧乙基磷酸胆碱。本发明通过对3D打印生物墨水的具体组成进行设计，制备得到了打印性能好、力学强度好、电传导性能好、打印后细胞存活率高的3D打印生物墨水，进而制备得到了细胞‑支架相互作用较强的3D打印支架，可用于制备皮肤损伤修复材料。

微结构的增材制造

Resumen de: WO2024165390A1

The invention relates to a method for additive manufacturing of a microstructure (10) for selective transmission of X-ray or gamma-ray radiation. The method includes depositing (110) a layer of powder on a build plate or on a layer from at least one previous manufacturing step on the build plate, wherein the layer of powder comprises a high-Z material powder. Furthermore, the method includes selectively melting (120) and solidifying the powder to form septa wall structures (20) by scanning an electron beam in a spot sequence on the layer of powder to sequentially expose a plurality of spots (40) on the layer of powder to an electron beam spot. A size of the electron beam spot is at most 150 μm in diameter, preferably at most 75 μm in diameter, and more preferably at most 50 pm in diameter. The high-Z material powder comprises a high-Z material having an atomic number Z of at least 40, and preferably at least 70. The invention also relates to a microstructure for selective transmission of X-ray or gamma-ray radiation, which microstructure has been obtained by the method, and to an imaging component comprising such microstructures. The invention also relates to a method for manufacturing an imaging component.

Chamber with a flow system for bioprinting and culturing tissue models

Resumen de: PL132037U1

Przedmiotem zgłoszenia jest komora z układem przepływowym do biodrukowania i hodowli modeli tkankowych zawierająca: korpus (1) komory z otworem środkowym przesłoniętym szkiełkiem dolnym (2), przykryty z wierzchu pokrywą (3) zaopatrzoną w otwór środkowy przesłonięty szkiełkiem górnym (5), przy czym pomiędzy korpusem (1) komory i pokrywą (3) komory znajduje się silikonowa uszczelka obwodowa (4), gdzie korpus (1) komory na swoich dwóch przeciwległych końcach zaopatrzony jest w złącza (8) z kanałami łączącymi (10) zapewniającymi połączenie płynowe z objętością roboczą komory wyznaczoną przez ściany wewnętrzne korpusu (1) komory i pokrywy (3), uszczelkę obwodową (4) i powierzchnie wewnętrzne szkiełka dolnego (2) i szkiełka górnego (5) skierowane ku sobie nawzajem, gdzie układ przepływowy jest utworzony przez złącza (8) wraz z kanałami łączącymi (10) oraz objętość roboczą komory zawartą pomiędzy nimi; oraz obudowę zewnętrzną komory złożoną z ramki dolnej (6) i ramki górnej (7), przy czym korpus (1) komory i pokrywa (3) komory wraz z elementami zawartymi pomiędzy nimi są zamknięte pomiędzy ramką dolną (6) i ramką górną (7) obudowy zewnętrznej, które połączone są ze sobą rozłącznie.

Casing that strengthens and seals the bioprinted tissue model

Nº publicación: PL132035U1 15/09/2025

Solicitante:

POLBIONICA SPOLKA Z OGRANICZONA ODPOWIEDZIALNOSCIA [PL]
POLBIONICA SP\u00D3\u0141KA Z OGRANICZON\u0104 ODPOWIEDZIALNO\u015ACI\u0104