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TOOL FOR USE AS A MICROMANIPULATOR AND METHOD FOR PRODUCING THE TOOL

Resumen de: WO2024120583A1

The invention relates to a tool for use as a micromanipulator and to a method for producing the tool. The tool consists of a plurality of parts in the form of - a frame (1) which is oriented along a longitudinal axis (L) and which is arranged as a hollow body around an interior, - at least one manipulator element (2) arranged on a first end face (1.1) of the frame (1), and - at least one actuation element (3) which is arranged on a second end face (1.2) opposite the first end face (1.1) and which is mounted slidably and axially movably in the interior of the frame (1), said parts being connected interlockingly and movably to one another by means of necessary connecting and bearing elements, and the tool being entirely generated by additive manufacture, including all the necessary gaps between the parts movably connected to one another. According to the method, the tool with all its parts and with the gaps between the movable parts is manufactured entirely by additive manufacture in one processing operation.

PHOTOINTIATOR, BIOINK INCLUDING THE SAME, AND METHODE OF MANUFACTURING HYDROGEL

Resumen de: EP4582433A1

The present disclosure relates to a photoinitiator, a bioink including the same, and a method of manufacturing a hydrogel. According to the present disclosure, the photoinitiator of the present disclosure may have water solubility, high molar extinction coefficient, and low cytotoxicity. In addition, the method of manufacturing a hydrogel of the present disclosure may have high cell viability by increasing 3D printing efficiency due to a fast photo-curing rate.

SYNTHETIC BONE GRAFTS AND METHODS FOR THEIR PREPARATION

Resumen de: WO2024047045A1

The present invention provides methods for the preparation of synthetic bone grafts which are made of a composition comprising two matrixes, one ceramic including interlocked CDHA crystals, and another of one or more binder(s), the two matrixes being admixture. The method comprises the preparing of an ink composition, the 3D-printing, and the hardening of the binder and ceramic components, in this order. The resulting bone grafts, which are characterized by including the two matrixes in admixture, shows improved mechanical properties as well as excellent biological properties.

GUIDANCE IN SPATIAL SETUPS OF A ROOM IN A MEDICAL FACILITY

Resumen de: WO2024047098A1

The present invention relates to guidance in spatial setups of a room in a medical facility. In order to provide improvements for a facilitated work procedure in medical interventions, a device (10) for guidance in spatial setups of a room in a medical facility is provided that comprises a data input (12), a data processor (14) and an output interface (16). The data input is configured to provide procedure data (18) about a current executed medical procedure. The data input is also configured to provide spatial data (20) of at least one of the group of staff and equipment relating to the currently executed medical procedure. The data processor is configured to calculate upcoming physical movement of at least one of the group of the staff and the equipment based on the procedure data and the spatial data procedure data. The data processor is also configured to determine, based on the calculated upcoming physical movement, at least one of the group of equipment movement instructions (22) and staff spatial guidance (24). Further, the output interface is configured to provide at least one of the group of the equipment movement instructions and the staff spatial guidance.

SURGICAL INSERT AND BONE CEMENT

Resumen de: WO2024047317A1

The present invention relates to a surgical insert (1) comprising a first layer (11) and a second layer (12), wherein the first layer and the second layer comprise openings (111, 112) having a figure-of-eight shape. The invention also relates to a bone cement comprising a pulverulent solid phase that comprises natural polysaccharides and a ceramic filler, a liquid acrylate, and a polymerising agent.

ARTICLES INCLUDING A MICROSTRUCTURED CURVED SURFACE, TOOLING ARTICLES, AND METHODS

Resumen de: WO2024047419A1

The present disclosure provides a microstructured article including a thermoplastic polymer shaped to have a curve. At least a portion of the curve includes a microstructured surface of utilitarian discontinuities and the microstructured surface includes peak structures and adjacent valleys. The peak structures and the curve are formed of a single piece of the thermoplastic polymer. A method of making the microstructured articles is also provided including a) obtaining a tool shaped to include at least one of a protrusion or a concavity; b) disposing a microstructured film on at least a portion of the tool including the protrusion and/or the concavity; and c) thermoforming a single piece of thermoplastic polymer onto the tool to form a microstructured article shaped to include a curve. The curve is an inverse of the protrusion or the concavity of the tool.

一种骨软骨修复支架及其制备方法

Resumen de: CN120267892A

本申请公开了一种骨软骨修复支架及其制备方法，其中，骨软骨修复支架包括依次连接的软骨下骨层、钙化软骨层以及软骨层，钙化软骨层包括钙化软骨上层、钙化软骨中层、钙化软骨下层，以及镶嵌在钙化软骨上层、钙化软骨中层内的多孔凝胶，本申请实施例中，采用上述的一种骨软骨修复支架及其制备方法，采用分层结构模拟人体生理软骨，通过钙化软骨层的分层及梯度孔隙率设计，不仅提升了支架的柔韧性，改善支架的使用性能，而且能够确保支架在植入到骨软骨缺损部位后能够快速招募患者的自体血液，从而引导骨髓间充质干细胞在软骨层分化为软骨细胞，促进软骨组织生成。

光引发剂、包含其的生物墨水以及制造水凝胶的方法

Resumen de: EP4582433A1

The present disclosure relates to a photoinitiator, a bioink including the same, and a method of manufacturing a hydrogel. According to the present disclosure, the photoinitiator of the present disclosure may have water solubility, high molar extinction coefficient, and low cytotoxicity. In addition, the method of manufacturing a hydrogel of the present disclosure may have high cell viability by increasing 3D printing efficiency due to a fast photo-curing rate.

一种具有光敏抗菌性的钙-钛八面体及其制备方法和应用

Resumen de: CN120269016A

本发明公开了一种具有光敏抗菌性的钙‑钛八面体骨缺损修复复合材料及其制备方法。本发明通过抑制病源微生物活性，重建骨内微观‑宏观结构，纠正微环境离子‑结构紊乱，促进感染性骨缺损再生。钙‑钛八面体复合材料具有独特的光催化效应，在420‑460nm波长的蓝光催化下能有效抑制细菌生长。此外，在微酸性环境下，八面体离子笼内的Ca2+与H+自发进行离子交换，升高微环境pH，释放Ca2+辅助骨修复。钙‑钛八面体与胶原类支架交联构成的复合支架材料具备良好的力学性能，可以基于应力匹配，模拟各种骨质类型，恢复骨宏观结构完整性。

一种骨再生多重仿生支架材料及其制备方法

Resumen de: CN120267891A

本发明公开了一种骨再生多重仿生支架材料及其制备方法，涉及仿生骨技术领域；本发明的一种骨再生多重仿生支架材料及其制备方法，是先以聚乳酸嵌段共聚物为原料采用3D打印技术制得符合骨缺损形貌的基底支架，再将基底支架在胶原蛋白混合溶液和改性层状双氢氧化合物溶液中进行交替浸渍多次，在基底支架表面形成由胶原蛋白/层状双氢氧化合物组成的仿生基质层，最后将表面附着有仿生基质层的基底支架依次在磷酸氢二钾和氯化钙溶液进行多次交替浸泡，在表面附着有仿生基质层的基底支架上原位矿化形成钙磷酸盐纳米粒子，最后进行清洗、干燥得到；本发明制得的骨再生多重仿生支架材料的生物相容性较好，力学性能较好。

基于多材料数字化光处理的个性化耳模一体制造方法

Resumen de: CN120269828A

本发明实施例公开了一种基于多材料数字化光处理的个性化耳模一体制造方法，涉及增材制造技术领域。其中，方法包括：获取特定患者的个性化耳模三维数值模型；为数值模型添加基于助听器自重的静态载荷，以及基于咀嚼运动周期性力的动态载荷，并基于添加的载荷对数值模型进行动态应力分析；基于应力分析结果，在数值模型中划分不同硬度的材料区域，包括刚性支撑区域、柔性密封区域和过渡区域；根据应力梯度线，确定过渡区域内各位置处用于DLP三维打印的刚性材料和柔性材料的体积分数；根据体积分数，以及刚性支撑区域和柔性密封区域的打印能量密度，确定过渡区域内各位置处的打印能量密度。本实施例能够提高耳模制造的质量和效率。

一种金属增材制造高耐磨异构股骨髁假体及其制造方法

Resumen de: CN120267444A

本发明公开了一种金属增材制造高耐磨异构股骨髁假体及其制造方法，假体包括：第一平面、第二平面、第三平面以及第四平面，各平面沿着根据患者的股骨远端的骨性解剖特征排列并一体化成型；每个平面包括细晶层、强韧基体层和力学匹配多孔接触层，所述力学匹配多孔接触层与股骨远端的创面接触，所述强韧基体层与力学匹配多孔接触层呈一体化，所述细晶层设置在最外层，所述力学匹配多孔接触层具有多孔结构；所述第二平面设有用于第二平面上固定假体的固定钉。本发明通过利用激光原位重熔技术对假体运动曲面进行作用，假体表面金属组织快速凝结形成晶粒细化，从而实现膝关节假体表面性能的提高。

一种医用镁合金锚钉及其制备方法

Resumen de: CN120242145A

本发明涉及医疗器械技术领域，尤其涉及一种医用镁合金锚钉及其制备方法，其技术方案包括锚钉材料，所述锚钉材料是由3D打印制备的二氧化锆、聚己内酯、PLGA中的至少一种构成了镁合金锚钉的外结构支架；另外三种镁、锌、钙合金粉末制备得到的复合非晶合金填充在支架的孔隙当中，最后在锚钉表面进行表面处理。本发明相比于传统的镁合金锚钉，本发明利用3D打印的外结构支架以及内部高强度的非晶复合镁合金，为锚钉提供了稳定的支撑结构，这种结构设计能够有效维持植入后结构稳定性，在腐蚀后开始后也不会出现因为点蚀导致的力学性能瞬间丧失，克服了传统锚钉在骨内可能出现的由于早期腐蚀导致的结构完整性破坏、变形、移位等问题。

用于生产三维微孔细丝构建体的方法

Resumen de: WO2024133278A1

A method for producing a three-dimensional macro-porous filament construct having interconnected microporous filaments comprises: a) preparing a mixture comprising particles of one or more metals, one or more metal alloys or a combination thereof, one or more binders, a first liquid solvent for the one or more binders, and optionally one or more dispersants; b) dispersing particles containing at least one removable additive in said mixture; c) depositing said mixture in the form of filaments in a predetermined three-dimensional pattern of interconnected filaments, thereby creating a three-dimensional filament-based porous green structure; d) contacting the three-dimensional filament-based porous green structure formed in step c) with a second solvent which is a non-solvent for the one or more binders to induce phase inversion thereby creating a filament-based phase inverted porous structure having a filament micro-porosity, whereby at least part of said filaments are transformed to a solid state; e) removing the at least one removable additive by dissolving in a removal agent to create additional micro-porosity in the phase inverted porous structure; f) subjecting the thus obtained structure to a thermal treatment. The removal agent comprises or consists of the second liquid solvent, or the removal agent is a third liquid solvent distinct from the second liquid solvent.

颅骨缺损修复材料及其3D打印制备方法

Resumen de: CN120242142A

本发明公开了一种颅骨缺损修复材料及其3D打印制备方法。颅骨缺损修复材料的3D打印制备方法包括利用由聚己内酯和含镁磷酸三钙粉体得到的丝材，通过3D打印获得具有预定形状和尺寸的颅骨缺损修复材料；所述3D打印制备方法还包括热压退火步骤：将制备的颅骨缺损修复材料置于40‑75℃的环境下，同时向所述颅骨缺损修复材料施加压力，以进行热压退火，获得成品材料。该颅骨缺损修复材料具有降解周期长、生物活性优和力学强度高的优点。

一种基于3D打印的可矿化引导骨再生膜及其制备方法和应用

Resumen de: CN120242154A

本发明提供了一种基于3D打印的可矿化引导骨再生膜及其制备方法和应用，涉及骨组织再生技术领域。本发明中所述可矿化引导骨再生膜的制备方法包括前驱液制备、DLP 3D打印、表面矿化等步骤。本发明通过数字光处理3D打印技术保障膜的结构适配性，通过ZIF‑8矿化层激活成骨细胞生物活性，通过智能降解体系维持膜的力学支撑与骨再生动态平衡，最终实现“结构‑功能‑代谢”三位一体的骨修复调控，具有优异的临床转化潜力。

一种可溶性微针及其制备方法

Resumen de: CN120242289A

本发明公开了一种可溶性微针及其制备方法，可溶性微针包括针尖和基底，所述基底包括上表层、中空层和下表层；所述针尖由上针和下针组成；基底的上表层和下表层均为非离子型高分子化合物；针尖的上针为疏水类的有机硅物料，下针为带电荷的高分子材料；其中上针为中空圆柱体，下针呈菱形，上针与下针承插连接，药物设置在中空层和下针；本发明提供一种可溶性微针，利用该微针可根据用药计量的要求，调整微针载药量，适用性强。

一种智能可控超变形鼻假体

Resumen de: CN120241325A

一种智能可控超变形鼻假体，属于整形外科医疗器械领域，将内凹型空心Ω形结构框架主体壳层、Janus界面外覆涂层与智能响应材料结合，构造“解剖‑结构‑功能”一体化鼻假体，在鼻假体腹侧进行微孔设计和羟基磷灰石涂层，形成高贴合性、高稳定性的鼻假体结构，在鼻假体背侧进行光滑设计和亚精胺涂层，从而抑制包膜形成，避免包膜约束，结合内凹型空心Ω形结构设计，实现超定向变形性能，智能响应材料的应用可在术中或术后通过温度信号进行非侵入式变形调整，满足术中与术后微调的临床需求。鼻假体可应用于整形、术后修改、修复重建等场景中，满足更高层次的医疗与美学需求。

一种负泊松比的光致动器

Resumen de: CN120242306A

本发明属于医疗器械技术领域，涉及一种负泊松比的光致动器，包括负泊松比框架、液晶弹性体套管和光纤。负泊松比框架的结构单元为双箭头形，双箭头形由高V形和低V形组成，高V形的两边等长，低V形的两边等长，低V形位于高V形内，低V形的两端分别与高V形的两端连接；液晶弹性体套管的中心轴平行于负泊松比框架的纵向，与负泊松比框架固定连接，位于负泊松比框架的内部正中间；液晶弹性体套管的中心轴与光纤的出射光轴共线，液晶弹性体套管的后端套在光纤的前端上；液晶弹性体套管受到从光纤出射的红外激光照射时收缩，去除所述红外激光照射后回弹。本发明采用负泊松比结构与光致动方式，使器件力学性能与心脏收缩特性匹配。

一种高通量多材料3D打印机

Resumen de: CN120245413A

一种高通量多材料3D打印机，属于打印机设备技术领域，包括打印机本体，还具有控制系统、打印系统和环境系统；控制系统包括3D打印机的控制主板、操作屏幕、电脑主机；打印系统包括多套龙门架构、传送带打印平台、阵列打印喷嘴机构、生物墨水池、蠕动泵、控温模组、光照模组、零件盘，环境系统包括洁净模块、灭菌模块、温度及湿度控制模块，控制系统、打印系统和环境系统和打印机本体安装在一起。本发明实现了同时打印多个模型的能力，大幅提高了打印效率；打印过程形成流水线模式，进一步提高了生产效率；能根据不同打印需求更换不同类型的打印喷嘴、使用更加便利；为生物材料打印提供了理想的环境条件；能确保打印过程的精准和稳定。

应用于3D打印的铌铜合金粉末、其制备方法及应用

Resumen de: CN120243953A

本发明公开了应用于3D打印的铌铜合金粉末、其制备方法及应用，3D打印技术领域。本发明采用喷雾造粒和等离子体球化工艺相结合的方法制备Nb‑Cu合金粉末，制备得到的铌合金粉末致密且为球形，具有极佳的流动性与堆积密度，匹配合适的3D打印工艺参数，使得样品成型后的致密度高达99.5％，远高于其他传统粉末冶金烧结法制备的样品致密度。同时，铌合金粉末中Cu已经均匀分散，而且氧含量低，使得金属制品的组成非常均匀，加之激光选区熔融成型工艺具有极高的冷却速率，使得金属制品的晶粒较小，因此本方法制备的3D打印铌铜合金制品具有较好的机械性能，可制备形状更为复杂的骨科医疗零件。

一种用于低特征表面的磁锁定3D打印弹性导板及其制作方法

Resumen de: CN120241176A

本发明关于一种用于低特征表面的磁锁定3D打印弹性导板及其制作方法，涉及手术导板技术领域。包括导向通道、刚性连接段、磁吸座和弹性连接轴；导向通道贯穿设置在弹性连接轴顶部的中间位置，弹性连接轴的两端均连接有刚性连接段，刚性连接段的两端均连接有磁吸座，磁吸座底端设置有凹槽，凹槽内嵌设有磁体。本发明针对人体低特征表面，以及具有一定活动度的部位，能够实施手术精准定位，彻底解决了人体低特征区域定位问题。

负压产生装置及应用

Resumen de: CN120242203A

本发明公开了负压产生装置及应用，该装置包括本体和连接于本体的握持部，本体顶端设有开口，本体底端设有多个通孔，开口和通孔之间连接壁面，使壁面内由开口至通孔形成腔体；本体还设有：控制模块，控制模块设于壁面外；料仓，料仓为无顶盖的筒状结构；筒底部设有若干小孔；料仓上设有升降模块，所述升降模块连接驱动机构以使料仓在腔体内进行上升或下降；驱动机构连接控制模块；握持部两端开口，一端连通于本体的底端，另一端为负压作用口。本发明的负压产生装置结构简单，使用方便，该装置底部的负压作用口可精准适配身体各个部位，用于在身体部位产生负压。通过控制模块对升降模块的位移，使料仓靠近或远离负压作用口，实现负压作用口附近的自动控温。

一种3D打印模型

Resumen de: CN120241299A

本发明公开了牙种植体技术领域的一种3D打印模型，包括模型本体和模型基台，所述模型本体的上端固定开设有安装孔，所述安装孔的内部设有螺纹，所述模型本体的下端固定连接有连接轴杆，所述连接轴杆的表面固定设置有固定螺纹圈，所述模型基台的表面固定开设有安装槽口，所述安装槽口的底部固定开设有固定孔，所述固定孔的内部设置有固定螺纹。此设置使得种植体固定效果更好，不会产生轻微转动，同时整个工艺因不需要使用替代体的缘故，对工艺进行了良好的简化，减轻了产品的生产力压力。

A MAGNETIC SUBSTRATE BASED TISSUE SCAFFOLD AND A METHOD FOR THE PRODUCTION OF THIS TISSUE SCAFFOLD WITH THE SUPPORT OF A 3D PRINTER

Nº publicación: WO2025144252A1 03/07/2025

Solicitante:

T C ANKARA UNIV REKTORLUGU [TR]
GAZI UNIV REKTORLUGU [TR]
T.C. ANKARA UNIVERSITESI REKTORLUGU,
GAZI UNIVERSITESI REKTORLUGU