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METHODS FOR THE RAPID MANUFACTURE OF CONJUGATE VACCINES THAT ELICIT ROBUST IMMUNE RESPONSES

Resumen de: WO2026080514A1

The disclosures of the invention arc directed to the manufacture of effective, affordable vaccines that arc globally accessible. Using a platform conjugation technology, highly immunogenic conjugate vaccines were produced that elicit broad cross-neutralization to variants of concern (VOC), manufactured cheaply compared to mRNA vaccines. Protein-protein conjugates and Toll-Like Receptor (TLR) agonist adjuvants were shown to enhance immunogenicity and induce broad cross-protection against VOC, a characteristic lacking in early mRNA CO VID-19 vaccines. Murine nAb titers from Beta-only conjugates were equivalent between Beta, Delta, Omicron BA.l, BA.2, and BA.4/BA.5, which were circulating up to three years after the antigenic strain. Additionally, Beta-Delta bivalent conjugate vaccines readily prevented disease in hamster challenge, which demonstrates a vaccine with remarkably broad cross-protection and potential to protect for extended periods despite mutations, without requiring expensive boosters or antigen adaption. This vaccine can be produced in our highly automated, large-scale manufacturing facility enabling economical production of inexpensive, effective vaccines for high-need areas.

SULFUR DIOXIDE DOSING APPARATUS AND METHOD

Resumen de: EP4726022A1

0001 A device and method for dosing sulfur dioxide (SO<2>) gas into wine contained in wooden barrels, comprising an application lance comprising a nozzle having larger holes that allow both the entry of wine into the nozzle and the exit of SO<2> gas from the nozzle, generating a gas flow sufficient for a homogeneous distribution of the gas within the barrel; and a support comprising a base and legs that support the application lance on the upper wall of the barrel near the area of the bung, wherein the support of the application lance comprises a base that in the position of use is horizontal to the wall of the barrel, raised only a few centimeters from the wall of the barrel.

MULTIPLE SINGLE NUCLEOTIDE POLYMORPHISM-BASED PORCINE 50K LIQUID CHIP, AND USE THEREOF

Resumen de: EP4722386A1

This invention relates to the field of genetic molecular breeding, specifically to a pig 50K liquid-phase chip based on multiple single nucleotide-polymorphism and its application. The probe design of the chip in this invention takes into account the distribution of captured SNP loci across the genome, the polymorphism of the loci, the quality of mSNP markers, and other issues, effectively avoiding problems such as uneven marker density and poor polymorphism. It also considers the quality of mSNP markers and the issue of linkage disequilibrium among mSNP markers. While adhering to the basic principles of liquid-phase chip design, genomic regions with moderate linkage disequilibrium between markers were selected, generating more SNP markers with high genotyping quality and moderate linkage disequilibrium within the probe region with the target loci. The mSNP liquid-phase chip of this invention expands the detectable number of SNPs to 1.5-2 times that of the target loci, addressing the issue of the relatively small number of high-quality mSNP markers in traditional liquid-phase chips without increasing costs.

GRAPE WINE OR FRUIT WINE FERMENTATION NUTRITIONAL AGENT AND USE THEREOF

Resumen de: EP4722328A1

0001 A grape wine or fruit wine fermentation nutritional agent and a use thereof. The grape wine or fruit wine fermentation nutritional agent comprises the following components in percentage by weight: 85-99% of a glutathione-containing yeast product, and 1-15% of cellulose and/or a cellulose derivative. By means of the synergistic effect of a yeast product and a cellulose substance, the content of solids in grape juice is ameliorated, and a carrier is provided for uniform distribution of yeast, and the fermentation nutritional agent can also reduce harm of harmful substances generated in the fermentation process, thus improving the fermentation environment, and enhancing the fermentation effect.

GENETICALLY MODIFIED PORCINE CELL, GENETICALLY MODIFIED PIG AND METHODS OF PRODUCING SAME

Resumen de: EP1000000A1

The invention relates to an apparatus (1) for manufacturing green bricks from clay for the brick manufacturing industry, comprising a circulating conveyor (3) carrying mould containers combined to mould container parts (4), a reservoir (5) for clay arranged above the mould containers, means for carrying clay out of the reservoir (5) into the mould containers, means (9) for pressing and trimming clay in the mould containers, means (11) for supplying and placing take-off plates for the green bricks (13) and means for discharging green bricks released from the mould containers, characterized in that the apparatus further comprises means (22) for moving the mould container parts (4) filled with green bricks such that a protruding edge is formed on at least one side of the green bricks.

ROTARY WINE GLASS

Resumen de: EP4721627A1

The present disclosure discloses a rotary goblet includes a cup body, a base, a connecting rod, and at least a bearing. The connecting rod is threadedly connected to the bottom of the cup body. The bearing is installed on the top of the base. An internal thread is provided on the inner side of the inner ring of the bearing, an external thread corresponding to the internal thread is provided on the outer side of the bottom of the connecting rod, and the bottom of the connecting rod is threadedly connected to the inner side of the inner ring of the bearing. A connecting base is installed at the bottom of the cup body, an internal threaded hole is provided on the inner side of the connecting base, a stud corresponding to the internal threaded hole is provided on the top of the connecting rod, and a mounting hole for positioning and installing the bearing is provided on the top of the base. The present disclosure has a simple structure, is stably placed, rotates smoothly and stably. When it is necessary to shake the liquid in the cup body, rotating the goblet realizes automatic rotation decanting of the goblet on the desktop. The cup body can also be normally placed flat on the desktop as a normal goblet, serving two purposes in one cup, meeting the diverse needs of users, being easy to operate and use, and providing a good consumer experience.

Device for Infusing Food

Resumen de: US20260090678A1

A device for infusing food includes a receptacle attachment element, such as a cork; a vent assembly; a flow valve; and an infuser conduit. The receptacle attachment element attaches to an opening of a receptacle that contains a substance to be infused into a food item, such as a watermelon, and the infuser conduit is in fluid communication with the receptacle attachment element to receive the substance therethrough. The infuser conduit is able to pierce through the food item and insert thereinto to infuse the substance into the food item. In some examples, the substance is flavoring and/or alcohol, such as wine or spirits.

NON-ALCOHOLIC BEVERAGE AND METHOD FOR PRODUCING SAME

Nº publicación: EP4717095A1 01/04/2026

Solicitante:

KIKKOMAN CORP [JP]
Kikkoman Corporation

Resumen de: EP4717095A1

Problem: To provide a wine-flavored non-alcoholic beverage that can be easily prepared by diluting a genuine non-alcoholic beverage having good compatibility with cuisines such as Japanese food, Western food, and Chinese food with various fruit juices and the like; and a method for producing the same.Solving Solution: Raw materials of the beverage include star anise, black pepper, and dried bonito flakes. By subjecting immersion mixed water obtained by immersing the raw materials in water at 80°C to 130°C to heated extraction, and then to solid-liquid separation, a heated water extract liquid of the raw materials, which serves as a base of the non-alcoholic beverage, can be obtained. When this beverage is diluted with various fruit juices and the like, it becomes a red wine-flavored non-alcoholic beverage.