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LastUpdate Última actualización 16/10/2026 [07:35:00]
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TREATMENT AND DIAGNOSIS OF MELANOMA

NºPublicación:  US20260272867A1 17/09/2026
Solicitante: 
UNIV ROCKEFELLER [US]
The Rockefeller University
US_20260272867_A1

Resumen de: US20260272867A1

The present invention discloses novel agents and methods for diagnosis and treatment of melanoma. Also disclosed are related arrays, kits, and screening methods.

BIOMARKERS FOR NEURODEGENERATIVE DISEASE

NºPublicación:  US20260272976A1 17/09/2026
Solicitante: 
NEUVIVO INC [US]
UNIV CALIFORNIA [US]
Neuvivo, Inc.
The Regents of the University of California
US_20260272976_A1

Resumen de: US20260272976A1

0000 Described herein are methods of monitoring and treating a subject with ALS based on biomarkers.

DIGITAL OLFACTORY DATA SERVICE PLATFORM

NºPublicación:  WO2026192093A1 17/09/2026
Solicitante: 
ILIAS AI CO LTD [KR]
\u321C\uC77C\uB9AC\uC544\uC2A4AI
WO_2026192093_A1

Resumen de: WO2026192093A1

The present invention provides a digital olfactory data service platform comprising: a digital olfactory data collection system including a multi-channel olfactory sensor array provided to be able to collect digital olfactory data by using various types of odor collection samples collected in a plurality of fields, and a sensing management module provided to be able to manage the odor collection samples and the digital olfactory data; a digital olfactory AI data service system including a digital olfactory data lake, a digital olfactory data service management module, and a digital olfactory data management module, storing olfactory sample-related metadata, digital olfactory data, digital olfactory recognition data, and sensor management data, providing various data management functions stored in the digital olfactory data lake, and providing functions such as product management and subscription management for data services; and an olfactory recognition AI deep learning system including an olfactory recognition deep learning model for performing AI deep learning on the digital olfactory sensor data.

METHODS OF MONITORING SPLICING

NºPublicación:  US20260276651A1 17/09/2026
Solicitante: 
RAGE BIOTECH PTY LTD [AU]
RAGE BIOTECH PTY LTD
US_20260276651_A1

Resumen de: US20260276651A1

0000 The present invention relates to methods for identifying the splicing of RAGE pre-mRNA resulting in the inclusion of exon 9b and/or exclusion of exon 10 in a subject in a subject who has received, or is receiving an antisense oligonucleotide that modulates RAGE pre-mRNA splicing. In one aspect, the present invention provides a method for determining endogenous soluble receptor for advanced glycation end products (RAGE) level in the lung of a subject, the method comprising: determining the presence of endogenous soluble RAGE in a blood sample from a subject who has received or is receiving a treatment administered to their respiratory tract, wherein the treatment increases endogenous soluble RAGE, wherein the level of endogenous soluble RAGE in the blood sample correlates with the endogenous soluble RAGE level in the lung of the subject.

COMPOSITIONS AND METHODS FOR IMPROVING BRAIN FUNCTION

NºPublicación:  AU2025235500A1 17/09/2026
Solicitante: 
BALCHEM CORP
UNIV OF VERMONT AND STATE AGRICULTURAL COLLEGE
BALCHEM CORPORATION
UNIVERSITY OF VERMONT AND STATE AGRICULTURAL COLLEGE
AU_2025235500_PA

Resumen de: AU2025235500A1

Methods for improving brain function and increasing brain activity by oral administration of choline are provided. Compositions including unit doses of choline sufficient to provide improved brain function and increasing brain activity are also provided. In some embodiments, it includes a method for improving brain function and/or increasing brain efficiency in a subject in need thereof, the methods comprising administering a pharmaceutical composition comprising 550 mg or greater of choline. The increases in brain efficiency are measured by functional Magnetic Resonance Imaging, as compared to placebo, when the subject is performing an N-Back task.

CHEMICAL PROBES FOR UNFOLDED, MISFOLDED OR INTRINSICALLY DISORDERED PROTEINS

NºPublicación:  AU2025232230A1 17/09/2026
Solicitante: 
UNIV LA TROBE
LA TROBE UNIVERSITY
AU_2025232230_A1

Resumen de: AU2025232230A1

Disclosed herein are chemical probes for unfolded, misfolded or intrinsically disordered proteins, in particular chemical probes having the structure of Formula I or salts thereof, and to the use of the probes for various applications relating to unfolded, misfolded or intrinsically disordered proteins, for example, for diagnosing or prognosing a disease or disorder associated with an unfolded, misfolded or intrinsically disordered protein.

PROTEIN MARKERS FOR MILD COGNITIVE IMPAIRMENT AND ALZHEIMER'S DISEASE

NºPublicación:  US20260279589A1 17/09/2026
Solicitante: 
UNIV HONG KONG SCIENCE & TECH [CN]
HONG KONG CENTER FOR NEURODEGENERATIVE DISEASES LTD [CN]
The Hong Kong University of Science and Technology
Hong Kong Center for Neurodegenerative Diseases Limited
US_20260279589_A1

Resumen de: US20260279589A1

The present invention relates to protein markers relevant to mild cognitive impairment (MCI) and Alzheimer's disease (AD), especially those detectable in blood samples. Thus, methods and compositions are provided for risk assessment and early diagnosis of MCI and AD based on the analysis of these protein markers. Further provided are methods and compositions useful for evaluating the efficacy of a therapy for MCI or AD.

SCREENING METHOD FOR COMPOUND INDUCING AUTOPHAGY

NºPublicación:  US20260276625A1 17/09/2026
Solicitante: 
UNIV TOHOKU [JP]
TOHOKU UNIVERSITY
US_20260276625_A1

Resumen de: US20260276625A1

Provided is a screening method for searching for a new autophagy-inducing compound. In the present invention, a new autophagy-inducing compound is searched for using at least one of the following characteristics: (1) having high binding affinity for DEAD-box RNA helicase; (2) approximating DEAD-box RNA helicase and p62 to promote interaction; and (3) promoting droplet formation of DEAD-box RNA helicase and p62.

METHODS OF TREATING ALZHEIMER'S DISEASE

NºPublicación:  US20260274931A1 17/09/2026
Solicitante: 
KLARITOS INC [US]
KLARITOS, INC
US_20260274931_A1

Resumen de: US20260274931A1

Disclosed herein are methods of conducting clinical trials in Alzheimer's disease (AD). Methods of selecting a medicament and treating an AD subject are disclosed. Methods, systems, kits, and devices for selecting a subject in AD clinical trials and treatment protocols are disclosed herein.

METHOD, SYSTEM, AND PATCH FOR EXAMINING LIVING ORGANISMS

NºPublicación:  US20260276647A1 17/09/2026
Solicitante: 
PITTAN INC [JP]
PITTAN INC.
US_20260276647_A1

Resumen de: US20260276647A1

The present invention makes it possible to acquire biological information relating to an examination subject more easily or more accurately and to provide the biological information to a user. This living organism examination method for providing biological information relating to an examination subject (1), which is a living organism, by analyzing biological components in the sweat of the examination subject includes: a collection step (S101) for collecting sweat from an examination site of the examination subject (1); a measurement step (S102) for measuring a biological component profile of the sweat collected in the collection step; a biological information acquisition step (S103) for acquiring biological information relating to the examination subject (1) on the basis of the biological component profile measured in the measurement step; and an information provision step (S104) for providing the biological information relating to the examination subject, acquired in the biological information acquisition step, in a predetermined format.

BIOMARKERS OF AMYOTROPHIC LATERAL SCLEROSIS AND USES THEREOF

NºPublicación:  US20260276655A1 17/09/2026
Solicitante: 
METHODIST HOSPITAL [US]
COYA THERAPEUTICS INC [US]
The Methodist Hospital
Coya Therapeutics, Inc.
US_20260276655_A1

Resumen de: US20260276655A1

The present disclosure relates to biomarkers and uses thereof in methods for selecting a patient diagnosed with amyotrophic lateral sclerosis (ALS) for an ALS therapy. The present disclosure further relates to methods for identifying the severity of ALS in a patient, treating an ALS patient, and monitoring efficacy of an ALS treatment.

ベータヒドロキシブチラート(BHB)を酸化する酵素、テストストリップ、及びそれらを使用するセンサー

NºPublicación:  JP2026531565A 17/09/2026
Solicitante: 
ザリージェンツオブザユニバーシティオブカリフォルニア
JP_2026531565_A

Resumen de: WO2025054130A1

The present disclosure relates to enzymes capable of oxidizing betahydroxybutyrate (BHB). In aspects, the enzymes are engineered to optimize BHB activity. Engineered enzymes including amino acid substitutions, truncations, and sequence deletions are further provided. The disclosure further provides for use of enzymes described herein, for example, in test strips, BHB sensors, devices, and systems for detecting and measuring BHB concentration.

DEMENTIA DIAGNOSIS SYSTEM AND DEMENTIA DIAGNOSIS PROGRAM

NºPublicación:  WO2026191421A1 17/09/2026
Solicitante: 
MIRAI SAIBO KOBO CO LTD [JP]
\u682A\u5F0F\u4F1A\u793E\u672A\u6765\u3055\u3044\u307C\u3046\u5DE5\u623F
WO_2026191421_A1

Resumen de: WO2026191421A1

Provided are a dementia diagnosis system and a dementia diagnosis program that are capable of identifying a patient having dementia with high accuracy by a simple and easy test. A dementia diagnosis system (1) has: a measurement unit (51) that continuously measures the acidity/basicity of a body fluid obtained from a subject; a confirmation unit (52) that confirms, for the acidity/basicity continuously measured by the measurement unit (51), an outlier at which the acidity/basicity becomes alkaline and the presence or absence of a change point at which the acidity/basicity persistently shifts to the alkaline side after the outlier is confirmed; and a prediction unit (53) that predicts whether or not the subject has dementia on the basis of the confirmation result of the confirmation unit (52).

HUMANIZED APOE ANTIBODIES OR BIND PORTIONS THEREOF, AND USES THEREOF

NºPublicación:  WO2026193055A1 17/09/2026
Solicitante: 
MASSACHUSETTS EYE AND EAR INFIRMARY [US]
THE GENERAL HOSPITAL CORP [US]
MASSACHUSETTS EYE AND EAR INFIRMARY
THE GENERAL HOSPITAL CORPORATION
WO_2026193055_A1

Resumen de: WO2026193055A1

Described herein are humanized anti-ApoE antibody molecules, antigen-binding portions thereof, and uses thereof.

GUT MICROBIOTA-RELATED METHODS FOR TREATING DEMENTIA AND AGE-DEPENDENT COGNITIVE DECLINE

NºPublicación:  US20260276656A1 17/09/2026
Solicitante: 
UNIV FREIBURG ALBERT LUDWIGS [DE]
Albert-Ludwigs-Universitat Freiburg
US_20260276656_A1

Resumen de: US20260276656A1

The present invention concerns new approaches for the diagnosis and treatment of dementia diseases. In particular, the present invention pertains to new markers for diagnosing dementia diseases as well as to new targets for the treatment of dementia diseases.

METHODS OF DETECTING, TREATING, AMELIORATING, AND/OR PREVENTING COGNITIVE DECLINE

NºPublicación:  WO2026193298A1 17/09/2026
Solicitante: 
TEMPLE UNIV OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION [US]
TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
WO_2026193298_A1

Resumen de: WO2026193298A1

Described herein is a method of diagnosing or predicting the risk of cognitive decline in a subject, and/or stratifying the subject according to the risk. The method comprises determining a profile of the subject; and predicting the risk based on the profile, or stratifying the subject to a high risk group or a low risk group based on the predicted risk. The profile comprises blood pressure; and the level of homocysteine (Hyc) in a biological sample from the subject. Also described herein is a method of treating, ameliorating, and/or preventing cognitive decline in the subject based on the prediction of the risk.

SIMULATION DEVICE TO GENERATE HYBRID IN-VITRO/IN-SILICO NEURONAL POPULATIONS IN A CLOSED LOOP WITH MULTI-ELECTRODE ARRAYS

NºPublicación:  WO2026190495A1 17/09/2026
Solicitante: 
IMBB FORTH [GR]
UNIV OF PADOVA [IT]
IMBB-FORTH
UNIVERSITY OF PADOVA
WO_2026190495_A1

Resumen de: WO2026190495A1

The present invention refers to the field of in-vitro neural network stimulation, and particularly to devices that utilize cell cultures on multi-electrode arrays (MEAs) for investigating neuronal activity in research and drug testing applications. The invention consists of a closed loop system wherein a computational model stimulates via the electrodes of a MEA, cultured neurons on top of the MEA in order to produce disease- like activity states. The produced activity feeds back to the computational model, in real or periodic time, producing a hybrid neuronal population that can be used for drug screening. The respective method for the application of the abovementioned system is also disclosed.

ALPHA-SYNUCLEIN ANTIBODIES FOR USE IN DIAGNOSTIC ASSAYS AND TREATMENT OF ALPHA-SYNUCLEINOPATHIES

NºPublicación:  WO2026190230A1 17/09/2026
Solicitante: 
H LUNDBECK AS [DK]
H. LUNDBECK A/S
WO_2026190230_A1

Resumen de: WO2026190230A1

The present invention relates to alpha-synuclein antibodies which are useful in diagnostic assays for detecting aggregates, oligomers and fibrillar forms of alpha- synuclein in patient samples. These antibodies enable diagnosis and efficient treatment of alpha-synucleinopathies such as Parkinson's Disease (PD) or Multiple System Atrophy (MSA) patients by assessing and monitoring the pathological alpha-synuclein levels in patients.

METHODS OF ADENOVIRAL GENE THERAPY

NºPublicación:  WO2026193412A1 17/09/2026
Solicitante: 
ENSOMA INC [US]
ENSOMA, INC.
WO_2026193412_A1

Resumen de: WO2026193412A1

Among other things, the present disclosure provides adenoviral vectors, genomes, and methods of use thereof. In some embodiments, the present disclosure provides methods of in vivo gene therapy comprising administration of an adenoviral payload vector and an adenoviral integration vector. The present disclosure provides, among other things, compositions comprising an adenoviral payload vector and an adenoviral integration vector for use in, e.g., methods of in vivo gene therapy. In some embodiments, the present disclosure provides adenoviral vectors, genomes, and compositions thereof comprising a therapeutic sequence, e.g., a nucleic acid sequence encoding a CYBB therapeutic polypeptide. In some embodiments, the present disclosure provides methods of treating various conditions, disorders, and diseases, e.g., chronic granulomatous disease.

ANALYTE SIGNATURES OF LONG COVID AND USES THEREOF

NºPublicación:  WO2026193026A1 17/09/2026
Solicitante: 
CENTER FOR IMMUNOLOGY SCIENCE [US]
CENTER FOR IMMUNOLOGY SCIENCE
WO_2026193026_A1

Resumen de: WO2026193026A1

The invention provides methods for determining if a subject suffering from SARS-CoV-2 infection is susceptible to developing fibromyalgia. Also provided herein are methods for identifying if a subject possesses a disease or condition characterized or caused by an immune system deficiency, such as chronic pain or fatigue, long COVID or interstitial cystitis (IC).

Methods For Inhibiting Neuronal Degeneration To Preserve Residual Functionality And Enhance Axonal Fusion

NºPublicación:  US20260273141A1 17/09/2026
Solicitante: 
US GOV VETERANS AFFAIRS [US]
UNIV PENNSYLVANIA [US]
United States Government As Represented By The Department Of Veterans Affairs
The Trustees of the University of Pennsylvania
US_20260273141_A1

Resumen de: US20260273141A1

Disclosed herein are methods of inhibiting sterile alpha and TIR motif-containing protein 1 (SARM1) NADase activity in an axon. The methods can also be used to reduce or delay degeneration in an axon, treat or prevent degeneration of an injured axon, enhance fusion of one or more severed axons, and delay degeneration of one or more fused axons, as well as treat a neurological nerve injury or a neurodegenerative disease in a subject in need thereof using a SARM 1 inhibitor.

HIGH-SENSITIVITY IMMUNOASSAY METHOD AND SYSTEM

NºPublicación:  WO2026189109A1 17/09/2026
Solicitante: 
MACCURA BIOTECHNOLOGY CO LTD [CN]
\u8FC8\u514B\u751F\u7269\u80A1\u4EFD\u6709\u9650\u516C\u53F8
WO_2026189109_A1

Resumen de: WO2026189109A1

A high-sensitivity immunoassay method and system. The high-sensitivity immunoassay method for a target protein comprises: capturing the target protein to obtain a solution containing an immune complex; spreading said solution on a detection substrate under the action of a passive driving mechanism; immobilizing the immune complex on at least one surface; and performing detection and calculating the concentration of the immune complex. The immunoassay method uses a consumable structure having a simple structure and low costs, achieving highly sensitive detection of a target protein to be tested.

TARGETS AND METHODS OF DIAGNOSING, MONITORING AND TREATING FRONTOTEMPORAL DEMENTIA

NºPublicación:  US20260276657A1 17/09/2026
Solicitante: 
SIERKS MICHAEL [US]
WILLIAMS STEPHANIE [US]
UNIV ARIZONA STATE [US]
Sierks Michael
Williams Stephanie
ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY
US_20260276657_A1

Resumen de: US20260276657A1

Disclosed herein are antibodies, antibody fragments, binding agents, and compositions that specifically recognize protein variant biomarkers associated with frontotemporal dementia, kits and methods of use, including diagnosing, monitoring and treating frontotemporal dementia.

Senolytic car-T cells targeting uPAR, a cell surface and secreted senescence biomarker

NºPublicación:  AU2026205448A1 17/09/2026
Solicitante: 
MEMORIAL SLOAN KETTERING CANCER CENTER
Memorial Sloan Kettering Cancer Center
AU_2026205448_A1

Resumen de: AU2026205448A1

Abstract Provided herein are compositions and methods for adoptive cell therapy comprising engineered immune cells that express a uPAR-specific chimeric antigen receptor. Also disclosed herein are methods for using the engineered immune cells of the present technology to treat or ameliorate the effects of cancer and senescence-associated pathologies (e.g., lung fibrosis, atherosclerosis, Alzheimer's disease, diabetes, liver fibrosis, chronic kidney disease, aging, or osteoarthritis) by selectively targeting senescent cells. Also provided herein are methods for detecting the senescent cell burden in a patient. Abstract

SCHIZOPHRENIA BIOMARKER AND METHOD OF DIAGNOSIS AND KIT OF PARTS

Nº publicación: US20260275418A1 17/09/2026

Solicitante:

UNIV ANDRES BELLO [CL]
UNIV CHILE [CL]
UNIVERSIDAD ANDR\u00C9S BELLO
UNIVERSIDAD DE CHILE

US_20260275418_A1

Resumen de: US20260275418A1

A method is disclosed for detecting schizophrenia, at any stage, which comprises the steps of determining the gene expression of ZNF560 in a biological sample from a subject and comparing it with the ones of a healthy individual as a control sample, wherein the subject of the biological sample is diagnosed as having schizophrenia the gene ZNF560 is overexpressed in the biological sample in comparison to the control. Also disclosed is a kit of parts to diagnose schizophrenia from a biological sample and the use of the kit of parts as a detection agent useful to diagnose schizophrenia, wherein schizophrenia could be at prodromal, acute, residual, or chronic stage.

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