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56
resultados
Última actualización
24/04/2025 [07:26:00]
Resultados 25 a 50 de 56
Resumen de: AU2023334129A1
The invention relates to identification of an intron-retaining Tau splicing isoform as a novel Alzheimer's disease biomarker. Provided herein are polypeptides to generate binding molecules, such as antibodies specific for the Tau11i isoform, oligonucleotides and antibodies for use in methods for detecting the Tau11i isoform in a sample and methods for use in diagnosis for Alzheimer's disease.
Resumen de: AU2023329158A1
The invention relates to methods of detecting, diagnosing or monitoring an inflammatory condition of the central nervous system, in particular by detecting or measuring neutrophil extracellular traps, extracellular traps and/or cell free nucleosomes.
Resumen de: US2025093343A1
The invention provides assays and methods for characterization of specific extracellular vesicle (EV) populations, and to the preparation of improved EV compositions for therapy and diagnosis. Specifically, the invention in embodiments thereof provides methods and kits for analyzing blood-derived samples, as well as to the production and use of tissue-derived circulating EV populations characterized by unexpectedly small dimensions and advantageous properties.
Resumen de: US2025092361A1
A method of inhibiting phosphorylation of the tau protein and/or a TLR4-mediated immune response is disclosed. The method contemplates administering to cells in recognized need thereof such as cells of the central nervous system an effective amount of a of a compound or a pharmaceutically acceptable salt thereof that binds to a pentapeptide of filamin A (FLNA) of SEQ ID NO: 1, and contains at least four of the six pharmacophores of FIGS. 35-40.
Resumen de: WO2025057945A1
The present application includes: a method for determining whether a patient has cerebral amyloid angiopathy, the method comprising measuring the expression level of α1-acid glycoprotein in a sample collected from the patient; a method for determining the presence or the risk of side effects of a therapy using an anti-amyloid β antibody against Alzheimer's disease, the method comprising measuring the expression level of α1-acid glycoprotein in a sample collected from a patient; and a method for selecting a patient for a therapy using an anti-amyloid β antibody against Alzheimer's disease, the method comprising measuring the expression level of α1-acid glycoprotein in a sample collected from the patient; and the like.
Resumen de: WO2025058089A1
The purpose of the present invention is to provide an agent for suppressing amyloid β aggregation/deposition and an agent for suppressing/improving cognitive decline of a subject both of which are expected to have the effect of treating and/or preventing Alzheimer's disease. Specifically, the present invention pertains to an agent for suppressing amyloid β aggregation/deposition or an agent for suppressing/improving cognitive decline of a subject, the agent comprising an extract of a plant belonging to Myrtaceae.
Resumen de: AU2023264886A1
The present disclosure provides devices for the detection and/or quantification of neurotoxic amyloid-type protein aggregates, comprising a doxycycline derivative immobilized on an appropriate surface, as well as electrochemical and immunochemical methods associated to the use of such devices.
Resumen de: US2023160912A1
Disclosed are an immunoassay method capable of highly sensitively measuring amyloid β in a blood sample, and a kit therefor. The immunoassay method for amyloid β is a method of immunoassay of amyloid β in a blood sample, wherein the immunoassay is carried out in the presence of an anionic polymer such as a dextran sulfate salt or a polystyrene sulfonic acid salt. The kit for immunoassay of amyloid β in a blood sample comprises: an anti-amyloid β antibody or an antigen-binding fragment thereof; and an anionic polymer.
Resumen de: KR20250037394A
본 명세서에는 알츠하이머 환자에 특이적인 B 세포 수용체 클론형을 검출하는 제제를 포함하는 알츠하이머 예측 또는 진단용 조성물, 시스템 및 정보제공방법에 관한 것으로, 본 발명의 일 측면에 따른 조성물은 알츠하이머 환자에 특이적인 B 세포 수용체 (B cell receptor, BCR) 클론형을 검출하는 제제를 포함함으로써 방사성 물질을 사용하는 MRI와 PET 스캔의 방법 외에 병리적 특징의 발현이나 축적에 관계없이 비침습적이고 편리한 방식으로 단순히 피험자로부터 분리한 말초혈 단핵구를 이용하여 알츠하이머를 예측 또는 진단할 수 있는 우수한 효과가 있다.
Resumen de: AU2023347307A1
The disclosure relates to lemborexant, a dual orexin receptor antagonist, and compositions and methods for use in treatment of Alzheimer's disease (AD), e.g., in a subject who has AD or who is at risk for developing AD.
Resumen de: US2025084157A1
The invention relates to antibodies, antibody fragments and binding agents that specifically recognize oligomeric tau but do not bind to monomeric tau, fibrillar tau or non-disease associated forms of tau.
Resumen de: WO2025050415A1
Disclosed in the present invention is the use of peripheral blood macrophages in the preparation of a reagent and/or a drug for the diagnosis, prognosis and treatment of Alzheimer's disease (AD). The present invention will open new doors for a better understanding of the disease mechanisms of Alzheimer's disease and may guide development in new directions for early diagnosis, prognosis and treatment, so as to enable early prevention and treatment of Alzheimer's disease.
Resumen de: WO2025054610A1
Dementia is a brain disease which results in irreversible and progressive loss of cognition and motor activity. Despite global efforts, there are no simple and reliable diagnosis or treatment options. Embodiments of the disclosed technology provide an aptamer-based graphene field-effect transistor (GFET) biosensor platform that has high sensitivity and precision across a range of epidemiologically significant Alzheimer's disease and Parkinson's disease variants, and enables at-home and point-of-care (POC) testing for neurodegenerative diseases. An example method of detecting for detecting a molecular biomarker for dementia of a subject includes receiving a biological sample comprising the molecular biomarker for dementia, contacting the biological sample with a biosensor device comprising a GFET-based detection chip, and detecting a presence of the molecular biomarker for dementia in the biological sample.
Resumen de: WO2023214324A1
The present invention relates to a method for diagnosing neurodegenerative diseases, wherein said method comprises measuring the JNK3 levels in a biological sample selected from plasma, CSF, and saliva. In an embodiment, said method also comprises measuring P-JNK3.
Resumen de: AU2023264886A1
The present disclosure provides devices for the detection and/or quantification of neurotoxic amyloid-type protein aggregates, comprising a doxycycline derivative immobilized on an appropriate surface, as well as electrochemical and immunochemical methods associated to the use of such devices.
Resumen de: US2025064417A1
Disclosed are methods for using regional tau PET scans for identifying a subject having or suspected of having, diagnosing, and treating Alzheimer's disease. The methods are particularly useful for treating and diagnosing a patient as susceptible and at risk for developing amyloid-beta and cognitive dysfunction using tau-PET imaging based on regional tau PET measures.
Resumen de: MX2024009492A
Disclosed herein are methods of diagnosing, selecting, monitoring, and treating subjects with Alzheimer's disease (AD) or suspected of having AD or another disorder associated with amyloid accumulation in the brain.
Resumen de: CN118731373A
The invention belongs to the field of biological medicine, and particularly relates to a combination for joint detection of Alzheimer's disease biomarkers and application. The invention provides an application of a biomarker group in detection of Alzheimer's disease, and is characterized in that the biomarker group comprises: a) at least two of APOE4, GDF-15, UCH-L1 and PF4; or b) at least one of APOE4, GDF-15, UCH-L1 and PF4, as well as a phosphorylated Tau protein and a total Tau protein. The invention also provides a kit for detecting the Alzheimer's disease. According to the invention, more effective detection and diagnosis of the Alzheimer's disease are facilitated, and a new path is provided for detection and prevention of AD.
Resumen de: AU2025201059A1
The invention provides anti-Tau antibodies and methods of using the same.
Resumen de: WO2025046049A1
The present invention relates to molecules that are capable of binding to amyloid fibril aggregates. The invention further describes methods for detecting the presence of amyloid fibril aggregates in a sample or a subject. The invention even further describes methods for treating pathologies caused by amyloid fibril aggregates.
Resumen de: EP4516923A1
The present application relates to a digested DDIT4L product as a diagnostic marker for Alzheimer's disease, and use thereof in diagnosing Alzheimer's disease. In particular, the present application relates to use of a substance for detecting a digested intron retention (DIR) product encoding DNA-damage-inducible transcript 4 like (DDIT4L) in a sample of a subject in preparing a product for diagnosing Alzheimer's disease or a mild cognitive disorder and/or assessing (e.g., grading or staging) cognitive disorder progression, a related product thereof, and a method for screening a medicament using the DIR product.
Resumen de: US2022397580A1
The present disclosure relates generally to the field of neurology. In particular, the disclosure relates to a method of detecting a neurodegenerative disease in a subject and methods of treatment thereof. The methods include detecting the level of an exosome-bound aggregated biomarker in a sample obtained from the subject, wherein an increased level of the exosome-bound aggregated biomarker as compared to a reference indicates that the subject is suffering from a neurodegenerative disease. Also described are methods for detecting a subject at risk of developing amyloidosis or a neurodegenerative disease, methods for detecting and treating amyloidosis or a neurodegenerative disease in a subject, and methods of determining the aggregation state of a biomarker in a sample.
Resumen de: AU2023329330A1
Provided herein are antibodies, or fragments thereof, that specifically bind to a microtubule-binding region (MTBR) of tau, and uses thereof. Further provided are methods of detecting species of MTBR in blood or cerebral spinal fluid, and the use of such detection for diagnosing, prognosing, or staging pathological features and/or clinical symptoms of tauopathies, and to choose treatments appropriate for a given disease stage.
Resumen de: CN119534849A
本发明提供了一种监测阿尔茨海默病细胞周期—G2/M期的模型及其构建方法和应用，属于生物技术领域；本发明通过基因重组技术将APP/PS1双转基因小鼠和Fucci‑Green(G2/M期)报告基因小鼠杂交，得到阿尔茨海默病细胞周期G2/M期—Fucci‑Green报告基因小鼠APP/PS1::mAG‑hGem(1/110)，即所述监测阿尔茨海默病细胞周期—G2/M期的模型小鼠；所述监测阿尔茨海默病细胞周期的模型小鼠能够用于筛选阿尔茨海默病治疗药物，对阿尔茨海默病的机制研究及靶向药物开发具有重要的意义，具有很好的实用性。
Nº publicación: CN119534853A 28/02/2025
Solicitante:
东莞市厚街医院
Resumen de: CN119534853A
本发明提供一种基于液相芯片检测AD诊断标志物的方法及试剂盒，属于检测技术领域，所述检测方法是在样品和特异性微球免疫吸附反应体系或者交联反应体系中加入钙离子，所述样品包括标准品、待测样本、对照样本或者标记样本，所述钙离子由氯化钙、甘氨酸钙或者天门冬氨酸钙提供，通过钙离子能促进蛋白结合的特性提升了反应体系中两相互特异性结合的蛋白的结合效率，再配合甘氨酸和天门冬氨酸的促进作用能进一步的提升结合效率，可以极大的降低检测下限。
BOPI
Sede Electrónica
