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ORAL PRODUCTS, THREE-DIMENSIONAL PRINTERS USED FOR FORMING ORAL PRODUCTS, AND THREE-DIMENSIONAL PRINTING METHODS FOR FORMING ORAL PRODUCTS

Resumen de: US2025161207A1

A method of making an oral product includes printing a first product portion of an oral product using of a three-dimensional printer. The first product portion has a first composition. The method further includes printing a second product portion of the oral product using the three-dimensional printer, the second product portion having a second composition different from the first composition, the first product portion and the second product portion defining distinct, non-mixed regions of the oral product.

IMPLANT HAVING A SHAFT COATED WITH A WEB STRUCTURE

Resumen de: US2025161067A1

In various embodiments, an implant for interfacing with a bone structure includes a web structure including a space truss. The space truss may have a plurality of struts joined at nodes and the web structure is configured to interface with human bone tissue. At least some struts may form an irregular pattern in the web structure. The space truss may include two or more planar truss units having a plurality of struts joined at nodes.

Spinal Interbody Devices with Density Gradients and Associated Methods

Resumen de: US2025161068A1

An interbody device configured for insertion between adjacent vertebrae includes a body comprising and exterior surface and an interior surface defining a cavity. The body comprises a visualization window extending between the exterior surface and the interior surface, where the visualization window comprises a lattice of radiopaque structures. A density of the lattice in a central region of the visualization window is less than in the density of the lattice in an outer region of the visualization window such that the visualization window is radiolucent through the central region.

Partially Porous Tibial Component

Resumen de: US2025161060A1

A method for removing a stem portion of an orthopedic implant from a bone comprises exposing an implanted orthopedic implant having a body portion, a stem portion interconnected to the body and a porous metal section forming an interconnection between the body and the stem portion. A cutting tool is mounted on a holder connected to an exposed surface of the orthopedic implant. The porous section is aligned with the cutting tool mounted on the holder. The entire porous section is cut by moving the cutting tool therethrough in a direction transverse to the stem portion axis. The implant body portion is then removed and then the stem portion is removed from the bone. The cutting tool may be a saw or chisel which may be mounted on a guide fixed to the body portion.

PATTERNED IMPLANTABLE DEVICES FOR ADDRESSING TUBULAR TISSUE PASSAGEWAY DEFECTS AND METHODS OF MAKING AND USING SAME

Resumen de: US2025161028A1

An exemplary embodiment of the present disclosure An implantable device. comprising and external wall and a plurality of apertures. The external wall can have an open tubular shape. The plurality of apertures can be located in the external wall. At least a first portion of the plurality of apertures can be configured as suture holes for attaching the implantable device to the user. The implantable device can be configured to be implanted in a passageway of a user.

MOLD WITH WEAKENED REGION

Resumen de: US2025161006A1

A mold is for thermoforming a dental appliance. The mold includes a first section of the mold and a second section of the mold. The second section includes a feature having a complex shape, an undercut, or a bite edge. The mold further includes a weakened region that joins the first section to the second section. The weakened region is breakable, deflectable, or deformable in response to a first threshold force to enable the first section and the second section to be removed from the dental appliance after the dental appliance is formed over the mold. The first threshold force is less than a second threshold force that would damage or permanently deform the dental appliance.

MULTI-AXIAL POSITION SENSORS PRINTED ON A FOLDED FLEXIBLE CIRCUIT BOARD

Resumen de: US2025160716A1

A position sensor includes a flexible substrate formed into a three-dimensional (3D) shape. At least first and second field-sensing coils are formed in first and second respective layers of the flexible substrate, such that in the 3D shape the first and second field-sensing coils have first and second respective axes that are not parallel to one another.

SUTURABLE CUFF, METHOD OF INTEGRATING A TISSUE CONSTRUCT WITH A HOST ORGAN OR VASCULATURE, AND METHOD OF MAKING A SUTURABLE CUFF

Resumen de: US2025160834A1

A suturable cuff for integrating a tissue construct in vivo with a host organ or vasculature comprises a hollow body having an anastomotic end, an anchoring end, and one or more lumens, where each lumen extends through the hollow body from a proximal opening at the anastomotic end to a distal opening at the anchoring end. The anastomotic end is configured for integration with one or more body vessels, and the anchoring end includes one or more anchoring features for connection with the tissue construct.

ADDITIVE MANUFACTURING DEVICES AND METHODS

Resumen de: US2025162253A1

In the embodiments of the present disclosure, additive manufacturing devices and methods are provided. The additive manufacturing device includes a light source, a building device, and a light scattering member. The light source is configured to provide light to cure photocurable resins. The building device includes a resin tank configured to store the photocurable resins. The building device has a building surface on which the photocurable resins are cured. The light scattering member is arranged between the light source and the building surface.

PATIENT INTERFACE

Resumen de: US2025161616A1

A patient interface comprises a support structure and a seal-forming structure. The support structure is arranged to support the sealing portion and is configured to connect to the frame. The sealing portion comprises textile and is attached to the support structure along an outer perimeter of the sealing portion such that in use the sealing portion may be in tension due to reactive stress of the support structure and/or a resilient stretch characteristic of the textile such that the sealing portion exerts a force against the patient's face.

SELECTIVELY PERMEABLE ANNULUS FIBERS AND METHODS OF USING SAME

Resumen de: US2025161532A1

Aspects of the invention include systems and methods for producing selectively permeable cell laden solid core fiber structures, and for producing three-dimensional (3D) biological structures for digital files. In embodiments, the printed fibers comprise living cells embedded in at least one annulus layer or the printed fibers comprise a solid core of at least one biological material. The tissue fiber can be used in tissue engineering as synthetic tissue structures.

Allograft-Polymer Hybrids, Methods of Making and Methods of Use

Resumen de: US2025161533A1

Provided herein are bioresorbable, bioregenerative composite materials and compositions to regenerate tissues or organs to repair tissue or organ defects and constructs printed from the same as 3D structures shaped and sized to fill a tissue or organ defect. The composite materials are bioresorbable polymers, for example, polycaprolactone, and a bioresorbable graft material, for example, demineralized bone matrix. Also provided are methods for making the composite materials and compositions and methods for regenerating tissues or organs and repairing a tissue or organ defect using the constructs.

THREE-DIMENSIONAL SYNTHETIC LYMPHOID ORGANS AND ORGANOIDS FOR ANTIBODY DESIGN AND TESTING

Resumen de: US2025164465A1

Provided herein are methods and systems for bio-printing of three-dimensional organs and organoids. Also provided herein are bio-printed/extruded three-dimensional lymphoid organoids for use in the generation and/or the assessment of immunological products and/or immune responses. Also provided herein are methods and system for lymphoid organoids for use in antigen and epitope discovery, characterizing immune response, and therapeutic compounds testing.

CYBER-PHYSICAL WATERMARKING WITH INKJET EDIBLE BIOPRINTING

Resumen de: US2025166110A1

A method of ascertaining identity, verification, or authentication of a product is disclosed which includes embedding a predetermined watermark on a host image, thereby generating an edible watermarked image, printing the watermarked image using edible ink on an attack-resistant edible substrate, affixing the printed substrate onto the product, providing a color reference chart along with the watermarked image, obtaining an image of the watermarked image from the product, establishing correspondence between the watermarked image and the color reference chart, correcting the obtained image based on the established correspondence, extracting the embedded predetermined watermark from the corrected watermarked image, and determining identity, verification, and authentication of the product by analyzing the extracted predetermined watermark of the watermarked image.

DYNAMIC HYDROGEL COMPOSITIONS

Resumen de: AU2023375461A1

Compositions and methods for delivery of therapeutic agents to an individual in need thereof, for prevention/reduction of tissue adhesion, and for 3D printing are disclosed herein. In some embodiments, the composition comprises octadecyl modified hydroxypropyl methylcellulose (HPMC-C18) and a surfactant or cyclic polysaccharide, wherein the composition is a hydrogel that exhibits dynamic properties.

SOFT TISSUE RECONSTRUCTION IMPLANTS AND FORMING METHOD THEREFOR

Resumen de: AU2025203084A1

Embodiments herein relate to an implant for insertion into a patient. The implant comprises a plurality of unit cells arranged to form a three-dimensional lattice structure, the three-dimensional structure comprising a resting volume of the implant. The plurality of unit cells are arranged to form a porous network of the three-dimensional structure, and wherein the three-dimensional structure is a reversibly compressible three-dimensional structure, wherein a bulk porosity of the three-dimensional structure (101) of the implant is at least 50 %.

METHOD FOR MANUFACTURING CONNECTOR FOR SENSING AND STIMULATING MULTIPLE INTRACEREBRAL NEURAL SIGNAL THROUGH FORMATION OF LIQUID METAL WIRING ON SURFACE OF LIVING BODY

Resumen de: WO2025105628A1

The present invention relates to a method for forming a stretchable wire that connects a neural probe with a wireless device through high-resolution direct printing of a liquid metal on a biological surface. More specifically, the present invention relates to: a method for manufacturing a connector capable of sensing and stimulating signals in various regions of the brain by forming a stretchable wire at a high resolution directly on a biological surface such as the skull through 3D printing with an ink containing a gallium-based liquid metal alloy, wherein the connector connects a neural probe for sensing and stimulating intracranial neural signals with a wireless device; and a multi-channel intracranial neural signal detection and stimulation connector manufactured by the manufacturing method.

IMPLANTS FOR TEETH AND BONE

Resumen de: WO2025102118A1

The present disclosure relates to implants for teeth and bone. The implants are prepared from a polymer of the poly (aryl ether ketone) family, preferably poly ether ketone (PEK), and are activated with plasma to improve integration with teeth and bone. Methods and kits related to use of the implants are also disclosed.

歯科器具及び歯列矯正治療システム

Resumen de: WO2023231904A1

A dental instrument and orthodontic system, comprising: a first shell-shaped body (10) for accommodating maxillary teeth and a second shell-shaped body (20) for accommodating mandibular teeth. The buccal or lingual side of the posterior tooth area of the first shell-shaped body (10) is provided with a first type of protrusion (11), and the buccal or lingual side of the posterior tooth area of the second shell-shaped body (20) is provided with a limiting part (21) that cooperates with the first type of protrusion (11). The first type of protrusion (11) and the limiting part (21) interact with each other to adjust the relative positional relationship between the upper and lower jaws. The occlusal surface of the posterior tooth area of the first shell-shaped body (10) or the second shell-shaped body (20) is provided with a second type of protrusion (12) that protrudes toward the opposite jaw. The height of the second type of protrusion (12) compensates for the jaw opening space formed in the posterior tooth area after the interaction between the first type of protrusion (11) and the limiting part (21) to stabilize the occlusion state.

RADIATION CURABLE COMPOSITION FOR ADDITIVE MANUFACTURING PROCESSES

Resumen de: WO2025104550A1

The invention relates to a radiation-curable composition for additive-manufacturing processes, the composition comprising (meth)acrylate component A1 comprising a polyalkylene oxide backbone, with at least two (meth)acrylate moieties, not comprising a urethane moiety, and having a molecular weight Mw of at least 2,000 g/mol, (meth)acrylate component A1 being present in an amount of 50 to 85 wt.%, (meth)acrylate component A2 with at least two (meth)acrylate moieties, comprising in addition at least two urethane moieties, and having a molecular weight Mw of at most 1,000 g/mol, (meth)acrylate component A2 being present in an amount of 5 to 20 wt.%, (meth)acrylate component A3 with only one (meth)acrylate moiety, and having a molecular weight of at most 500 g/mol, (meth)acrylate component A3 being present in an amount of 5 to 20 wt.%, photo-initiator, and optionally stabilizer, wt.% with respect to the amount of the whole composition. The invention also relates to a process of producing an elastomeric 3-dim article by processing the radiation-curable composition, an elastomeric 3-dim article obtainable by such a process.

3D PRINTING OF A UNITARY PIECE IN A METAL MATERIAL

Resumen de: WO2025103994A1

The present invention relates to a dental or surgical handpiece (1) formed by a head (10) and a gripping handle (11), each provided with at least one integrated internal duct (2) selected from a pneumatic duct (20), a light transmission duct (23), and a blind duct (24) suitable for housing one or more electronic sensors (5), characterised in that at least one element selected from an internal shell (111) of the handle (11) and the head (11) is made by 3D printing in metal and contains the pneumatic duct (20) and/or the light transmission duct (23) and/or the blind duct (24) as an integrated internal duct (2) in a single unit.

LIVING BIOREACTOR COMPOSITIONS AND METHODS OF USE

Resumen de: WO2025106439A1

The present disclosure provides compositions comprising a structure for use as a therapeutic cell niche. Additionally, provided herein are methods for using such compositions, e.g., for use in cell therapy in a subject in need thereof.

FIBROCARTILAGE-DERIVED BIOINK COMPOSITION, BONE GRAFT COMPOSITION CONTAINING SAME, AND MANUFACTURING METHOD THEREFOR

Resumen de: EP4556032A1

The present invention relates to a fibrocartilage-derived bioink composition, a bone graft composition containing same, and a manufacturing method therefor. More specifically, it is identified in the present disclosure that the inner, mid, and outer compartments of the meniscal cartilage tissue based on anatomical location differ from each other in terms of physicochemical property, whereby use is made of the extracellular matrix derived from each compartmentalized tissue to provide 3D-printing bioink compositions and bone grafts, each having distinct physicochemical properties, which can be utilized with controlled physicochemical properties according to desired applications.

3-D BIOPRINTING COMPRISING BIOLOGICALLY-RELEVANT MATERIALS AND RELATED METHODS

Resumen de: WO2024015237A1

The present disclosure provides a method of bioprinting a 3-D structure comprising one or more biologically-relevant materials on a super-hydrophobic surface. In one embodiment, the method comprises providing a composition having one or more biologically-relevant materials dispersed within a biocompatible medium. A pattern comprising a hydrophilic material is deposited on a defined area of the super-hydrophobic surface, wherein the pattern is modeled after a biological structure. The composition having the one or more biologically-relevant materials is then bioprinted atop the hydrophilic surface to form a 3-D structure, wherein the hydrophilic surface maintains the 3-D structure in a desired position or shape on the super-hydrophobic surface.

CLEAR ORTHODONTIC ALIGNER

Nº publicación: EP4554509A1 21/05/2025

Solicitante:

FOND IRCCS CA GRANDA OSPEDALE MAGGIORE POLICLINICO [IT]
Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico

Resumen de: WO2024013670A1

The present invention relates to a clear orthodontic aligner comprising at least one molecule capable of changing color or color intensity (CCM). Furthermore, the invention relates to a process for obtaining a clear orthodontic aligner by means of three-dimensional (3D) printing.