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IN VITRO BIOPRINTED BONE MODELS AND BIOINKS FOR BONE BIOPRINTING

Resumen de: US2025172541A1

Embodiments pertain to a bioink operational to form an artificial bone. The bioink includes a plurality of bone-related cells. Additional embodiments pertain to an artificial bone that includes a plurality of bone-related cells; and a bioink of the present disclosure that is embedded with the cells. The artificial bone may be in the form of a three-dimensional structure that includes a plurality of channels operational to allow fluid flow through the artificial bone. Further embodiments pertain to methods of making an artificial bone by applying a plurality of bone-related cells and a bioink onto a surface such that the bioink becomes embedded with the cells and forms a three-dimensional structure with a plurality of channels.

INORGANIC STRUCTURE AND METHOD FOR PRODUCING INORGANIC STRUCTURE

Resumen de: EP4559600A1

An inorganic structure having mechanical properties that differ depending on the region in the inorganic structure, and a method for manufacturing the inorganic structure are provided. An inorganic structure (1) of the present embodiment includes a plurality of solidified portions (SA) composed of an inorganic material. The plurality of solidified portions (SA) include a first solidified portion (SA1) having a first crystallographic direction (CO1) preferentially oriented in a predetermined direction, and a second solidified portion (SA2) having a second crystallographic direction (CO2) that is a different orientation from the first crystallographic direction (CO1).

HYDROGEL WITH A HYDROPHILIC THICKENING POLYMER AND PARTICLES OF EGGSHELL MEMBRANE, AND ITS BIOPRINTED PRODUCTS

Resumen de: WO2024017906A1

The present invention concerns a composition which is a hydrogel comprising, in an aqueous medium: - at least one hydrophilic thickening polymer, and - particles of eggshell membrane, in an amount of less than 5% by weight of the total weight of the composition, wherein said particles are rod-shaped, needle-shaped or fibrous, having a specific particle size. It also relates to a bioink comprising said composition, to a method for manufacturing a 2D or 3D product using said hydrogel, to a kit comprising said hydrogel or bioink, and to uses thereof.

CURABLE COMPOSITION FOR PRODUCING TRANSPARENT ORTHODONTIC ATTACHMENTS

Resumen de: CN119584936A

The present invention relates to a curable composition comprising: a (meth) acrylate free of urethane moieties, a urethane (meth) acrylate, a photoinitiator, discrete filler particles having an average particle size in the range of 10 nm to 40 nm and having been surface treated with a silane surface treatment agent, the silane surface treatment agent is selected from the group consisting of silane surface treatment agents comprising (meth) acrylate moieties, silane surface treatment agents not comprising (meth) acrylate moieties, and mixtures of both, and the discrete filler particles are present in an amount of 20% by weight or more, the curable composition further comprising an additive selected from the group consisting of silane surface treatment agents comprising (meth) acrylate moieties, silane surface treatment agents not comprising (meth) acrylate moieties, silane surface treatment agents not comprising (meth) acrylate moieties, and mixtures of both. The curable composition does not contain, in each amount of 2 wt% or more, aggregate of nano-sized particles, fumed silica, wt% relative to the curable composition, alone or in combination: aggregate of nano-sized particles, aggregate of nano-sized particles, fumed silica.

用于产生具有异质性质的增材制造对象的方法

Resumen de: US2024051246A1

Methods for manufacturing objects are provided herein. In some embodiments, a method includes receiving a dental appliance formed using an additive manufacturing process, the dental appliance including a plurality of appliance portions. The method can include identifying, based on sensor data, a location of a subset of the appliance portions on the dental appliance. The method can further include applying energy to a subset of the appliance portions to selectively modify one or more material properties of the subset of the appliance portions.

一种用于脑电监测的半干电极及其制备过程

Resumen de: CN120036789A

本发明公开了一种用于脑电监测的半干电极及其制备过程，包括外壳、外壳顶部、电极触角、电解液缓释体和电极芯，其中电极触角包括弹簧触角和中空触角；电解液缓释体采用导电海绵、导电水凝胶或导电纤维织物等材料，确保电解液的均匀释放；制备方法采用三维建模与3D打印技术，精确控制电极形状和尺寸，降低生产成本并缩短制备时间。本发明利用弹簧触角和中空触角的组合结构提高接触时的稳定性。本发明的脑电半干电极为脑电监测过程中提供了一种更舒适可控的解决方案，通过压力调节电解液流速，同时弹簧触角缓冲接触压力，提高佩戴舒适性，能够提高信号质量，增强使用者的佩戴体验。

椎间融合器的制备方法、对应模型的生成方法及其装置

Resumen de: CN120046438A

本发明公开了一种椎间融合器的制备方法、对应模型的生成方法及其装置，该生成方法包括：接收患者病变部位的医学影像数据，生成患者的目标骨器官的装配模型；生成装配模型对应的有限元仿真装配模型，生成应力云图；将椎间融合器原始模型转变成隐式体，在隐式体的空间中填充随机种子；在隐式体中添加随机种子点；在隐式体中将随机种子之间生成连线，从而在隐式体中生成三维晶格，三维晶格即为椎间融合器模型。该生成方法能够根据椎间融合器在宿主体内所受应力，从而智能化驱动椎间融合器多孔结构排布，精准降低椎间融合器应力屏蔽效应。

一种唇腭裂畸形矫正术训练模型及其制造方法

Resumen de: CN120048175A

本发明公开了一种唇腭裂畸形矫正术训练模型及其制造方法。本发明中，通过精确的CT扫描和高级的三维重建技术，结合SLA 3D打印技术，能够直接从数字模型一步到位打印出唇腭裂畸形矫正术训练模型。这种一次成型的好处在于，它避免了传统制造方法中可能出现的多步骤组装和接合的复杂性和误差。每个模型都是一体成型的，确保了模型的准确性和结构的完整性。这种方法通过使用高级的材料和精细的3D打印技术，该方法能够制造出外观和质感都非常接近真实人体唇腭裂皮肤软组织的训练模型。这种模型的皮肤软组织部分具有与真实组织相似的弹性、质地和颜色，使得外科医生在进行手术训练时能够获得更加真实和直观地体验。

一种基于动态力学调控的3D生物打印骨软骨类器官、其构建方法及应用

Resumen de: CN120037458A

本发明提供了一种基于动态力学调控的3D生物打印骨软骨类器官、其构建方法及应用。与现有技术相比，本发明创新性地提出双相支架优化改性策略：首先采用3D生物打印技术制备具有精确分层结构的骨软骨水凝胶支架，继而通过动态压力刺激系统激活细胞机械转导信号通路，定向调控干细胞的软骨/骨双相分化；并且通过构建仿生力学微环境，使获得的骨软骨类器官不仅保持优异生物相容性，更具备梯度化机械性能和明确的空间分层结构（软骨层‑骨层），其定向成软骨/成骨分化效率提升显著，有效解决了骨软骨组织工程中空间异质性构建与细胞命运精准调控的难题，在骨软骨缺损修复治疗和力学刺激机制研究领域具有重要应用价值。

생체 인쇄된 연조직 강화 스캐폴드

Resumen de: AU2023346376A1

The disclosure encompasses systems, compositions, and methods for use in vivo, including for reinforcement of soft tissue in an individual. The systems, compositions, and methods may utilize three-dimensionally printed scaffolds comprising at least a polymer scaffold and an extracellular matrix component(s), including comprised on the scaffold. The polymer scaffold may comprise particular unit cell structures of a specific design and patterns of alternating configurations of the unit cell structures.

一种低浓度胶原蛋白的低温DLP 3D打印方法及其应用

Resumen de: CN120038939A

本发明属于3D打印技术领域，具体涉及一种低浓度胶原蛋白的低温DLP 3D打印方法及其应用。本发明首次意外发现在pH 3体系下可以显著提高光敏胶原蛋白ColMA生物墨水的打印性能，通过低温DLP 3D打印得到持久性的高活性胶原蛋白生物支架；相较于高浓度GelMA支架，所述低浓度ColMA生物支架具有更高的机械性能，更短的平衡溶胀时间、更低的溶胀比、更强的抗降解能力，以及更高的生物活性，可以显著促进人包皮成纤维细胞的增殖、粘附、迁移以及向肌成纤维细胞的分化，有效缓解大鼠全层皮肤损伤处炎症反应、促进伤口再上皮化和胶原有序沉积，加快全层皮肤损伤再生，在组织再生工程中具有广泛的应用前景。

一种具有光热治疗功能的PLA纳米CuS复合涂层的羟基磷灰石/58S生物活性玻璃复合陶瓷骨支架的制备方法

Resumen de: CN120037459A

本发明公开了一种具有光热治疗功能的PLA纳米CuS复合涂层的羟基磷灰石/58S生物活性玻璃复合陶瓷骨支架的制备方法。所述方法包括：（1）将羟基磷灰石与58S生物活性玻璃粉体按预定比例与光敏树脂配制陶瓷浆料，采用光固化技术成型后经脱脂烧结制得多孔陶瓷支架；（2）通过超声分散、磁力搅拌法使纳米硫化铜均匀分散于PLA/有机溶剂体系，采用浸渍提拉法在陶瓷基体表面构建纳米复合涂层，获得PLA负载纳米硫化铜的复合骨支架。所述58S生物活性玻璃可诱导类骨磷灰石成核及生长，改善支架生物活性；PLA纳米CuS复合涂层渗透到陶瓷支架的微孔和裂纹中，具有封孔效应，形成机械互锁，能有效提高力学性能。PLA纳米CuS复合涂层在近红外光照下产生光热效应，实现Cu²⁺可控缓释与光热转换，兼具长效抗菌和光热抑肿瘤功能。该支架在骨缺损修复与术后肿瘤防治领域具有重要应用价值。

复合体筒状仿生骨支架及其制备方法

Resumen de: CN120037447A

本申请涉及骨缺损修复技术领域，尤其是涉及一种复合体筒状仿生骨支架及其制备方法，包括以下步骤：再生材料制备、ZP支架制备、复合水凝胶制备、PH支架制备、支架组装：将ZP支架与PH支架进行紫外消毒处理，然后使用磷酸盐缓冲溶液冲洗处理，将内皮细胞以1×105mL植入PH支架内，并灌流培养6‑8天，再将ZP支架与内植有内皮细胞的PH支架进行组合，构成宏微结构的复合体筒状仿生骨支架。本申请的复合体筒状仿生骨支架及其制备方法，ZP支架和PH支架组合构成含有内外双仿生的血管化复合体筒状仿生骨支架，具有令人满意的生物相容性，并显着促进血管生成和成骨过程。

固体药物施用形式的制造方法

Resumen de: WO2024038000A1

The present invention relates to a process for the preparation of a solid pharmaceutical administration form comprising an amorphous solid dispersion using a 3D printing process. The process is a printing process that allows the production of a solid pharmaceutical solid administration form comprising an amorphous solid dispersion in an easy and flexible manner and the possibility to achieve fast disintegrating dosage forms with high drug loads.

牙科器具、系统和方法

Resumen de: WO2024079567A1

A dental appliance for a patient includes a body including a first surface and a second surface opposite to the first surface. The second surface defines a channel for receiving a plurality of teeth of the patient. The dental appliance further includes an arrangement of a plurality of features disposed on the first surface of the body. Each of the plurality of features includes a protrusion extending from the first surface opposite to the second surface; a depression extending partially from the first surface towards the second surface; or a through-hole extending from the first surface to the second surface. The arrangement of the plurality of features encodes a feature data representative of a dental appliance information of the dental appliance or a patient information of the patient.

Method for fabricating liquid metal-based interconnections and connector for detecting and stimulating neural signals by intercerebral neural probes

Resumen de: WO2025105628A1

The present invention relates to a method for forming a stretchable wire that connects a neural probe with a wireless device through high-resolution direct printing of a liquid metal on a biological surface. More specifically, the present invention relates to: a method for manufacturing a connector capable of sensing and stimulating signals in various regions of the brain by forming a stretchable wire at a high resolution directly on a biological surface such as the skull through 3D printing with an ink containing a gallium-based liquid metal alloy, wherein the connector connects a neural probe for sensing and stimulating intracranial neural signals with a wireless device; and a multi-channel intracranial neural signal detection and stimulation connector manufactured by the manufacturing method.

基于4D打印且可定制力反馈的智能关节康复支具及其制备方法和系统

Resumen de: CN120024028A

本发明公开了一种基于4D打印且可定制力反馈的智能关节康复支具的制备方法及系统，是根据关节部位的结构，确定适配于4D打印的结构形式，并预先确定所述结构形式中的结构参数以及关键结构参数与力反馈之间的映射关系，并嵌入模型设计软件中，可以根据所述映射关系以及康复需要的力反馈相应调节所述模型的关键结构参数得到支具片状模型；经4D打印使形成三维立体结构，调整后得到智能关节康复支具。相比于传统的支具制造技术，本发明制作的智能手部支具成本更低、制作速度更快并且能够具备实时感知患者力反馈大小的功能。

一种可原位移植的类阴道支架及其制备方法

Resumen de: CN120022425A

本发明提供了一种可原位移植的3D类阴道支架及其制备方法，涉及再生医学与组织工程技术领域。所述可原位移植的3D类阴道支架制备方法包括以下步骤：将猪阴道脱细胞基质原生胶与明胶甲基丙烯酰胺溶液混合，巴氏消毒之后，加入丝素蛋白，混合均匀，得到3D打印基质混合物；将3D打印基质混合物装入3D打印机；根据欲打印阴道结构应用CAD软件设计模型结构与参数，并对打印系统进行设置，边打印，边蓝光照射打印物，得可原位移植的3D类阴道支架。本发明所述可原位移植的类阴道支架生物安全性和机械性能好，尤其能够重建阴道组织，并具有功能学特性，从而可实现大、小动物阴道缺失模型的原位移植以及对缺失阴道组织的修复。

基于激光扫描技术的造口插入件

Resumen de: CN222889092U

本实用新型涉及医疗用具领域，具体为基于激光扫描技术的造口插入件，包括模具、造口插入件以及造口袋，模具包括外围的、凸起的、周向延伸的裙部，裙部限定最终模制的造口插入件的外边界，并且内部横截面为造口袋的开口，造口插入件包括套环以及造口插入芯，套环与造口插入芯之间贯穿有偏移孔，模具表面设有凸起和条纹区域，这些区域在造口插入件的皮肤接触面上产生互补的阴影线、刻痕或条纹表面。这不仅有助于将汗液、皮脂和其他体液引导远离造口，还有助于保持周围皮肤干燥，提供足够的支撑力。同时，表面光洁度可以进一步优化，如通过化学气相工艺平滑表面或涂覆不粘或低粘化合物，提高了造口插入件的功能性和舒适性。

储液装置

Resumen de: TW202500210A

A reservoir includes a liquid chamber, an atomization module, a detection module, a cover, and a bubble blocking structure. The liquid chamber has an opening, and a bottom of the liquid chamber has a through hole. The atomization module is disposed in the through hole. The detection module is disposed in the liquid chamber and adjacent to the through hole. The cover is disposed on the liquid chamber and covers the opening. The bubble blocking structure is disposed in the liquid chamber, and a projection of the bubble blocking structure vertically projected to the bottom of the liquid chamber at least partially overlaps with the through hole.

一种数字光处理（DLP）3D生物打印的个性化仿生骨软骨

Resumen de: CN120022421A

本发明属于3D打印生物医用材料技术领域，具体涉及一种数字光处理(DLP)3D生物打印的个性化仿生骨软骨。所述个性化仿生骨软骨由透明软骨层、钙化软骨层和软骨下骨层组成，通过DLP 3D生物打印技术进行制备；具有梯度增加的机械强度，稳定的抗溶胀性能以及适宜的生物降解性能；具有良好的生物相容性和显著的生物活性，能促进骨髓间充质干细胞的增殖、黏附和定向分化；同时能显著促进骨软骨再生，在临床上具有广泛的应用前景。

壳状牙齿矫治器系统

Resumen de: CN120022092A

本申请的一方面提供了一种扩弓或缩弓巩固期使用的壳状牙齿矫治器系统，它包括一系列逐次的壳状牙齿矫治器，用于逐次地佩戴于患者第一牙颌的牙弓，所述一系列逐次的壳状牙齿矫治器的每一个为一体的壳，形成容纳多颗牙齿的腔，该腔的几何形态使得所述一系列逐次的壳状牙齿矫治器能够将所述牙弓从扩弓或缩弓巩固期开始时的牙齿布局逐步地重新定位到扩弓或缩弓巩固期结束时希望达到的牙齿布局，所述第一牙颌是上颌或下颌，在所述扩弓或缩弓巩固期内，所述患者的第一牙颌佩戴有扩弓器或缩弓器。

3D Thermoplastic Three Dimensional bolus used in radiotherapy

Resumen de: KR20250072081A

본 발명은, 3D 볼루스에 관한 것이다. 본 발명의 3D 볼루스는 열가소성 필라멘트에 의한 용융 적층 방식으로 3D 프린팅된 3D 볼루스로서, 상기 열가소성 필라멘트는, PLA(Polylactic acid), TPU(Thermoplastic polyurethane), PETG(Polyethyene terephthalate glycol-modified) 및 HIPS(High Impact Polystyrene)으로 이루어진 군에서 선택된 1종 또는 2종 이상을 포함하고, 두께가 1.5 cm 이하인 것일 수 있다.

ORAL DRUG DOSAGE FORMS FOR STOMACH RETENTION

Resumen de: AU2023362040A1

Provided herein are drug dosage forms designed to provide a desired retention in an individual based on geometric differences between a pre-administration and post-administration state of the dosage form. In certain aspects, provided are oral drug dosage forms comprising a swellable and expandable material configured, upon swelling or expanding, to drive expansion of the overall size of the oral drug dosage forms such that the oral drug dosage forms are retained in the stomach for a desired period of time. In certain other aspects, provided is directed to components useful for the oral drug dosage forms taught herein. In certain other aspects, provided is directed to methods of designing, methods of making, such as involving three-dimensional (3D) printing, injection molding, ultrasonic welding, or any combination thereof, commercial batches, and methods of delivering a drug to an individual comprising administering an oral drug dosage form taught herein.

TEXTILE SEAL-FORMING STRUCTURE WITH MULTIPLE CURVATURES

Nº publicación: AU2025203195A1 22/05/2025

Solicitante:

RESMED PTY LTD
ResMed Pty Ltd

Resumen de: AU2025203195A1

0001 A patient interface including a seal-forming structure with a textile membrane that has at least one hole such that the flow of air at a therapeutic pressure is delivered to at least an entrance to the patient's nares and/or an entrance to the patient's mouth. The seal-forming structure is constructed and arranged to maintain the therapeutic pressure in a cavity of a plenum chamber throughout the patient's respiratory cycle, in use. The textile membrane includes a first portion that is held in a relaxed state and a second portion that is held in a taut state. The taut state of the second portion is configured to allow the seal-forming structure to include a three dimensional shape that has multiple curvatures.