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PRE-CONNECTED ANALYTE SENSORS

Resumen de: EP4725401A2

A system (101) for measuring an analyte concentration in a host comprises a transcutaneous analyte sensor (138); a bottom housing (522); a top housing (520); and sensor electronics (112) configured to connect to the transcutaneous analyte sensor (138). The sensor electronics (112) are configured to be disposed between the bottom housing (522) and the top housing (520). The bottom housing (522) includes a recess (726) with a floor (704), and the floor (704) includes a plurality of locating pins (784, 786), the plurality of locating pins (784, 786) extending upward from the floor (704). The plurality of locating pins (784, 786) are configured to extend into a plurality of holes (794, 796) in a substrate (404). A conductive member (762, 764) is configured to establish electrical connection between the sensor (138) and the sensor electronics (112).

EJECTION FRACTION FROM NON-CONTRAST COMPUTED TOMOGRAPHY

Resumen de: EP4725423A1

0001 For segmentation (310) and/or ejection fraction determination (320), photon-counting detection (100) for CECT in ES is used to create (110) virtual NCCT for machine training (130). The lack of NCCT data at ES for training (130) segmentation is overcome by use of the virtual NCCT. Since the segmentation (310) is trained (130) on non-contrast imaging at ES, accurate ES segmentation (310) from NCCT may be provided. The EF may be calculated (320) using NCCT.

METHOD FOR PRODUCING A REMOVABLE DENTAL PROSTHESIS, AND REMOVABLE DENTAL PROSTHESIS PRODUCED ACCORDING TO THE METHOD

Resumen de: WO2024251724A1

The invention relates to a method for producing a first connection element of a removable dental prosthesis, said connection element being suitable for a sliding connection between a first fit surface of the first connection element and a second fit surface of a second connection element of the removable dental prosthesis. The invention is characterized in that the first connection element is produced by connecting a stability-granting material and a ductile material which forms the first fit surface in an additive multi-material manufacturing method.

CONTACT LENSES INCLUDING MEDICAMENTS AND METHODS OF MAKING AND USING SAME INCLUDING SLOW RELEASE OF GLAUCOMA TREATING DRUGS AND COMFORT ENHANCING DRUGS

Resumen de: WO2024254134A2

The present invention recognizes that medical devices, such as but not limited to contact lenses, can be made having at least one coating layer provide drug storage and drug release tor the treatment of various diseases, disorders, or conditions, One aspect of the present invention includes a packaged medical device including a medicament. Another aspect of the present invention includes a drug delivery contact lens. A farther aspect of the present invention includes a. method of making a drug delivery contact lens. An additional aspect of the present invention includes a method of using a drug delivery contact lens. A further aspect of the present invention includes a medical device including bimatoprost and N-vinylpyrrolidone.

BIO-PRINTED SKIN MODEL, RELATED THREE-DIMENSIONAL PRINTING PROCESS AND DIRECT PERFUSION DEVICE PROVIDED WITH SAID MODEL

Resumen de: WO2024252292A1

The bio-printed skin model (1) comprises: - at least one dermal layer (2) comprising at least one polymer matrix and a mixture of fibroblasts and endothelial cells and configured to simulate a human dermal tissue; - at least one epidermal layer (3) comprising at least one mixture of keratinocytes and configured to simulate a human epidermal tissue; wherein the dermal layer (2) comprises at least one inner duct (4) formed by fibroblasts and endothelial cells, configured to simulate a vascular channel of human skin and provided with at least two end stretches communicating with the outside and connectable to a system for active perfusion of substances.

POWERED ORAL CARE IMPLEMENT INCLUDING A TRACKING MODULE AND TRACKING MODULE AND TRACKING MODULE THEREOF

Resumen de: EP4725359A2

0001 An oral care system that includes an oral care implement and a tracking attachment. The oral care implement may include a handle and a head. The tracking attachment is detachably coupled to the oral care implement. The tracking attachment may include a first component comprising a first housing having an inner surface that defines a first cavity and a second component comprising a second housing having an inner surface that defines a second cavity. When the tracking attachment is coupled to the oral care implement, a first portion of the handle is positioned within the first cavity and a second portion of the handle is positioned within the second cavity.

COMPUTER IMPLEMENTED METHODS AND SYSTEMS FOR GENERATING MODELS OF BONES, AND FOR ADDITIVE MANUFACTURING OF BONES

Resumen de: EP4725455A1

The present disclosure relates to computer-implemented methods (100) for generating a virtual model of a first section of bone tissue including cortical bone tissue. The method comprises (104) obtaining microstructural cortical parameters including an indication of a number of osteons (210) and of a cross-sectional area of the osteons, a number of lamellae (212) forming the osteons, an indication of locations of osteons in the section of bone tissue and of dominance of the osteons. The method further comprises generating a virtual model using a generative design algorithm comprising (1061) defining a geometric space, (1062) generating a cortical cloud of points, (1064) segmenting the geometric space into substantially circular regions, defining an outer surface of the osteons. The method further comprises (1065) forming consecutive substantially concentric surfaces corresponding to the lamellae until the obtained virtual model satisfies boundary conditions formed by the microstructural cortical parameters.

新規方法

Resumen de: WO2024201321A1

The present invention relates to a process for obtaining a dental prosthesis comprising a crown and tooth root. Said process comprises at least one step of directing undifferentiated cells or keratinocytes and at least one three-dimensional printing step, preferably 3D bioprinting of the dental prosthesis. Furthermore, the invention regards the dental prosthesis obtained with the process and a bioink suitable for three-dimensional printing (3D), preferably suitable for 3D bioprinting.

3D打印技术在脊髓灰质炎患者行走辅助工具的应用

Resumen de: CN121847809A

本发明公开了基于3D打印人体外骨骼的方法，包括有以下步骤：S1、三维扫描人体外表形状；S2、对扫描的人体信息进行传输和三维搭建；S3、人体外骨骼的三维设计；S4、3D打印机进行人体外骨骼打印；S5、对3D打印出来的实体进行打磨；本发明通过三维扫描人体外表形状，对人体外骨骼进行三维模型建设，通过关节模型库对关节连接结构进行选择使用，更加的贴合人体关节弯曲度，并且通过辅助蹲起模块设计连接端点，便于对弹簧或者液压机构进行安装连接，并且在人体外骨骼进行三维模型扫描处理后，根据三维模型扫描的结果进行控制3D打印机运行，使得3D打印机能够完成对外骨骼的打印。

バイオポリマーの官能化方法及びその架橋方法

Resumen de: WO2024196271A2

The invention relates to a method of functionalizing a biopolymer in which a biopolymer having -OH or -NH2 groups is reacted with at least one compound containing at least one C=C or C≡C bond and a chromophore group absorbing UV-Vis radiation directly adjacent to this bond. The invention also relates to a method for obtaining a solid biopolymer material, in which the functionalized biopolymer obtained by the method specified above is subjected to reversible cross-linking upon exposure to light in the UV-VIS range. The invention also relates to the use of a functionalized biopolymer as a support material for 3D bioprinting, as well as the use of a functionalized biopolymer for the production of structures selected from spheroids, organoids, artificial organs, coatings, and tissue models.

药物剂型及其制备方法

Resumen de: WO2025055893A1

Provided herein are a pharmaceutical dosage form and a method for preparing thereof, such as a pharmaceutical dosage form prepared by a three-dimensional printing method. Pharmaceutical dosage forms loaded with liquid or semi-solid materials, and pharmaceutical dosage forms loaded with solid material are both provided.

Surgical guides and processes for producing and using the same

Resumen de: US12599390B1

0000 Provided herein are 3D-printed patient-specific surgical guides and methods for making and using the same. In at least one embodiment, the guides include a first and second end, a first and second side, a conformal bone engaging surface, a front surface, one or more porous regions, one or more walls, and a plurality of openings. At least one of the plurality of openings extends through the guide between the conformal bone engaging surface and the front surface. The conformal bone engaging surface is contoured to a patient's anatomy. The first and second end, and the first and second side are contoured to avoid soft tissues of the patient.

音声を介して健康状態を診断するためのペアになったニューラルネットワーク

Resumen de: EP4145466A1

0001 A computer-implemented method (300), comprises: receiving a first audio signal corresponding to a first time period, wherein the first audio signal comprises speech of a person; computing (210) a first feature vector from the first audio signal; computing (220) a first speech embedding vector by processing the first feature vector with a neural network; receiving a second audio signal corresponding to a second time period, wherein the second audio signal comprises speech of the person; computing (212) a second feature vector from the second audio signal; computing (222) a second speech embedding vector by processing the second feature vector with the neural network; computing (330) an element-wise difference between the first speech embedding vector and the second speech embedding vector; and computing (340) a change value indicating a change in a health condition between the first time period and the second time period by processing the element-wise difference with a mathematical model.

モジュール式エネルギーシステム

Resumen de: WO2022208280A1

A modular energy system is disclosed including a header module including an enclosure and a display including a coupler. The enclosure defines a recess. The recess includes a first guidewall and a second guidewall. The coupler is removably positionable in the recess. The coupler includes a first sidewall and a second sidewall. The first guidewall is configured to guide the first sidewall as the coupler moves through the recess. The second guidewall is configured to guide the second sidewall as the coupler moves through the recess.

METHOD FOR DESIGNING PATIENT-SPECIFIC MANDIBULAR GUIDANCE AND DEVICE OFFERING IMPLANT AND PATIENT-SPECIFIC MANDIBULAR GUIDANCE THEREOF

Resumen de: KR20260050323A

환자 맞춤형 하악 가이던스를 설계하는 장치에 있어서, 환자의 하악골 이미지를 입력받는 입력부; 상기 입력된 하악골 이미지를 기반으로 환자의 해부학적 구조를 분석하고, 상기 분석된 환자의 해부학적 구조를 기초로 하악골 절제 부위 및 나사 위치를 포함한 하악 가이던스를 3차원으로 모델링하는 프로세서; 및 상기 모델링된 하악 가이던스를 표시하는 출력부;를 포함하는, 환자 맞춤형 하악 가이던스를 설계하는 장치를 제공한다.

Method and system for confirmation of microneedle-based analyte-selective sensor insertion into viable tissue via electrical interrogation

Resumen de: US12599337B1

A system and method to confirm the insertion of an analyte-selective sensor comprising an array of microneedles possessing vertical extent between 200 and 2000 μm into viable tissue is disclosed herein. Mechanical insertion of an analyte-selective sensor is firstly attempted by means of an application of external force. Either during or following this routine, an electrical stimulus is applied between at least two distinct electrodes located within the said analyte-selective sensor; a resultant response is measured. This response is compared with a reference value to determine if insertion was successful. If insertion was successful, no further effort is required and the sensor can operate as intended. However, if insertion was not successful, the user can be instructed to continue to apply additional force to said sensor to achieve successful insertion or otherwise re-apply the said sensor altogether.

System and method for providing dental services to a patient

Resumen de: US12603181B1

0000 A system and method providing a dental patient user interface to allow a patient to accurately scan existing patient dentures to provide a digital image for use by a provider to assess the needs and interests of the patient prior to a visit to then provide treatment facilitating/smile preview devices for use at the initial visit.

METHOD APPARATUS AND COMPUTER PROGRAM FOR CALCULATING BIOLOGICAL EFFECTIVE DOSE

Resumen de: KR20260050188A

본 발명에 따른 방사선량 산출 방법은, 대상체에 대한 입력데이터 -상기 입력데이터는 상기 대상체에 대한 기능 영상 및 해부 영상을 포함함- 를 수신하는 입력 단계, 상기 입력데이터에 기초하여 물리적 방사선량을 산출하는 제1 산출 단계 및 상기 물리적 방사선량에 기초하여 생물학적 유효 방사선량을 산출하는 제2 산출 단계를 포함하고, 상기 제1 산출 단계 및 제2 산출 단계는, 몬테카를로 기법에 기초하여 생성된 학습데이터를 이용하여 학습된 신경망 모델에 의한 제1 방식에 기초하여 수행되거나, 소정 수식에 의한 제2 방식에 기초하여 수행된다. 본 발명에 따르면, 인체 등 대상체의 조직에 대한 방사선량을 빠르고 정확하게 산출할 수 있게 되고, 핵종 또는 방사선의 종류 등에 따른 생물학적 유효 방사선량을 높은 정확도로 산출할 수 있게 된다.

WEARABLE ELECTRONIC APPARATUS FOR DETERMINING USER'S STATUS INFORMATION BASED ON USER'S BIOELECTRICAL SIGNAL AND CONTROL METHOD THEREOF

Resumen de: KR20260049425A

0001a 웨어러블 전자 장치가 개시된다. 본 웨어러블 전자 장치는 사용자의 귀에 착용되며, 제1 하우징 파트 및 제1 하우징 파트에 연결되는 제2 하우징 파트를 포함하는 하우징, 인스트럭션들을 저장하는 메모리, 제1 하우징 파트에 배치되며, 귀의 제1 면에 접촉되는 제1 전극, 제2 하우징 파트에 배치되며, 귀의 제2 면에 접촉되는 제2 전극, 제2 하우징 파트에 배치되며, 사용자의 매스토이드(mastoid) 영역에 접촉되는 제3 전극 및 프로세싱 회로(processing circuitry)를 포함하는 하나 이상의 프로세서를 포함하고, 인스트럭션들은, 하나 이상의 프로세서에 의해 개별적으로 또는 집합적으로(individually or collectively) 실행될 시, 웨어러블 전자 장치가 사용자에게 착용된 동안, 사용자의 귀의 제1 면에 접촉된 제1 하우징 파트의 제1 전극, 사용자의 귀의 제2 면에 접촉된 제2 하우징 파트의 제2 전극 및 사용자의 매스토이드 영역에 접촉된 제2 하우징 파트의 제3 전극을 통해 사용자의 생체 전기 신호를 획득할 수 있다.

一种用于修复下颌骨大范围缺损的3D打印PEEK网络支架的制备方法

Resumen de: CN121845802A

本发明公开了一种用于修复下颌骨大范围缺损的3D打印PEEK网络支架的制备方法，所属领域为生物医学工程与口腔修复领域，包括：通过引入力学计算公式，依据局部应力分布反推支架在特定区域所需的弹性模量，进一步优化支架的微观结构，确保支架在整个修复过程中能够动态适应骨组织的生长需求，从而有效促进内源性骨和血管的再生。

一种基于预制牙齿和CADCAM技术的牙科修复体制作方法

Resumen de: CN121845779A

本发明提供了一种基于预制牙齿和CADCAM技术的牙科修复体制作方法本发明公开了一种基于预制牙齿和CAD/CAM设备的牙科修复体制作方法，属于牙科修复体技术领域。该方法包括：预定义具备定位基准功能的加工工装；基于患者口内扫描模型选定预制牙齿，设计数字化修复义齿数据；生成义齿型盒三维数据（腔体由义齿表面法向反转所得）；合并加工工装、型盒和修复义齿，生成组织面切削路径；3D打印或切削制作实物型盒；插入预制牙齿并注入牙龈材料，凝固形成修复体毛坯；通过CAD/CAM设备切削加工组织面并抛光完成制备。本发明整合了预制牙齿的质量稳定、成本低廉优势与CAD/CAM技术的高效精准优势，避免了粘接精度误差，个性化适配性强，不依赖技师手工技艺，可批量化生产，制备的修复体形状精准、颜色自然，能满足患者功能与美学需求。

一种基于HAMA脂肪细胞微球与乳腺类器官的3D打印乳腺的方法

Resumen de: CN121845797A

本发明提供一种基于HAMA脂肪细胞微球与乳腺类器官的3D打印乳腺的方法，涉及生物医学技术领域，旨在解决现有技术中结构功能模拟不完整、细胞存活率低及分布不均等问题。核心技术方案包括：以HAMA脂肪细胞微球作为脂肪层功能单元，乳腺类器官作为腺体层单元，通过双喷嘴3D打印机实现双层结构的精准定位；通过调控HAMA交联度和微球孔隙率，提升脂肪细胞存活率；采用专用生物墨水和优化打印参数，使功能单元团聚率≤5%，并在界面设置交联过渡层促进结构连接；通过添加明胶和双重交联工艺，使模型压缩模量达10‑15kPa，降解周期3‑6个月，兼具良好力学性能和生物相容性。本申请有效地模拟乳腺生理微环境，在组织工程重建、药物筛选和疾病研究等领域具有重要应用价值。

用于关节假体的锆基合金原位氧化涂层的制备方法、医用关节假体及应用

Resumen de: CN121852847A

本发明公开了用于关节假体的锆基合金原位氧化涂层的制备方法、医用关节假体及应用，该方法适用于电子束熔化（EBM）、选择性激光熔化（SLM）制备或锻造加工的锆基合金（含 Zr‑2.5Nb、Zr‑Nb‑Ti、Zr‑Mo‑Nb 等体系），通过反复创建氧浓度梯度促使氧原子向材料内部扩散，精确形成高氧扩散过渡层与ZrO₂基原位氧化陶瓷涂层，同时建立氧化温度（T）‑陶瓷涂层厚度（d）‑耐磨性（WR）的耦合数学模型，实现涂层性能与产品尺寸的双重精准调控。本发明制备的涂层与基体通过高氧扩散过渡层紧密结合，过渡层深度超越传统工艺 40% 以上，氧化后假体尺寸变化量≤±0.01mm；涂层表面硬度≥1053Hv，磨损率≤0.8×10⁻⁶mm³/(N・m)，显著提升锆基合金的耐磨性能与尺寸稳定性，解决了关节假体长期服役中磨损碎屑导致的无菌性松动及尺寸精度失控问题，适用于髋关节、膝关节等医用关节假体的规模化生产。

基于AI与3D打印的多孔钽牙种植体的制造方法

Resumen de: CN121845774A

本发明提供一种基于AI与3D打印的多孔钽牙种植体的制造方法，涉及口腔医学与3D打印技术领域，包括：S1、建立历史CBCT数据集；使用历史CBCT数据集在AI建模平台中基于深度学习算法进行训练构建口腔重建模型；S2、根据患者口腔的CBCT生成相应的口腔重建模型；种植体三维模型包括牙冠、牙基座和种植基体；种植基体具有梯度多孔结构，由上至下分为孔隙率和孔径逐渐降低的表层区、过渡区和核心区；S3、调节种植体三维模型的形状和尺寸，对种植体三维模型进行优化；S4、3D打印得到种植体；S5、在种植基体的外表面以及内部孔隙的内壁表面制备羟基磷灰石涂层。本发明解决了现有技术中存在的种植体弹性模量不匹配、骨整合效率低及修复体适配性差的问题。

一种基于热响应的自适应3D打印放疗压舌板及其使用方法

Nº publicación: CN121846553A 14/04/2026

Solicitante:

重庆大学附属肿瘤医院

Resumen de: CN121846553A

本发明提供一种基于热响应的自适应3D打印放疗压舌板，压舌板为高硬度弹性支撑骨架与热塑形自适应层相结合的一体化成型复合结构，优选为邵氏硬度95A的热塑性聚氨酯制成的高硬度弹性支撑骨架和覆盖于骨架表面由聚己内酯制成的热塑形自适应层构成的双材料复合结构，采用多材料3D打印一体化成型，聚己内酯层在约70℃温水中可软化塑形，在常温或口腔温度下硬化定型；使用时，通过温水加热使自适应层软化，置于患者口腔内进行实时塑形，完美贴合牙齿、上颚及舌背的独特口腔结构，冷却后固定。本发明解决了传统压舌板个性化适配不足、无法适应分次治疗间组织变化的临床难题，实现了个性化贴合，显著提升了放疗摆位的精确性、重复性及患者舒适度。