Alerta

3D PRINTED CONDUCTIVE BIOPOLYMER FOR CARDIAC TISSUE ENGINEERING

Resumen de: US2025177607A1

An engineered material includes a conductive biopolymer including a plurality of layers, each of which includes methacrylated hyaluronic acid conjugated with at least one of 3-thiophene acetic acid and with poly(3-thiophene) acetic acid; and myocytes. The myocytes can include iPSC-derived cardiomyocytes. The myocytes can be substantially aligned in single lines. The single lines can be approximately parallel to one another and approximately normal to planes defined by the plurality of layers. A method of 3D printing the layers is also described.

DRUG-ELUTING SURGICAL ARTICLES AND METHODS OF USE THEREOF

Resumen de: US2025177290A1

Disclosed herein is a biomaterial and a method of use thereof for treating a condition. A biomaterial of the disclosure can be, for example, a surgical article. Implantation of a biomaterial disclosed herein into a subject can treat, for example, cancer.

POLYETHER-CONTAINING POLYMERIZABLE COMPOUNDS AND USE IN CURABLE RESIN COMPOSITIONS

Resumen de: US2025179236A1

This disclosure provides polymerizable resin compositions comprising a hydrophobic polyether-containing polymerizable polyurethane compound to impart improved stain resistance to polymeric materials formed from the polymerizable resin compositions. Further provided herein are methods of producing the compositions and using the same for the fabrication of dental devices, such as orthodontic appliances.

LASER MARKABLE RESIN COMPOSITIONS FOR ORTHODONTIC APPLIANCES

Resumen de: US2025179305A1

This disclosure provides laser markable polymerizable resin compositions comprising infrared absorbing marking additives to achieve improved laser markability of 3-D printed objects obtained from these polymerizable resin composition, and methods for marking the cured resin compositions using an infrared laser.

ADDITIVELY MANUFACTURED DENTURE BASE WITH BRACING BODY

Resumen de: US2025177102A1

The invention relates to additively manufactured dental devices comprised of a denture base and at least one removable bracing body joined at specific locations to the denture base. The invention also relates to methods of using these additively manufactured dental devices in the fabrication of dental prostheses.

MIXING AND COLORING DEVICE FOR DENTAL RESINS

Resumen de: US2025177090A1

A mixing and dyeing device for dental resins for 3D printing and is arranged for contactless dyeing by mixing fluid ingredients. The device includes a housing with a stabilizing means, a mixing means which is arranged for mixing resin housed within a container, the container provided within the housing, positioned concentrically with the mixing means, at least two pigment tanks, at least two dispensing means, a colour sensor which based on a template colour is arranged for determining proper amounts of the resin pigments fed from the pigment tanks, a scales positioned under the container, a device closing sensor, a temperature sensor, a control panel, and includes at least one heating means, which heating means is arranged for heating resin within the container, and a mixing arm has a tip enabling coupling replaceable mixing tips, and the colour sensor is arranged for scanning the patient's dentition.

STABLENEC STANDALONE INTERBODY

Resumen de: US2025177160A1

Implants include one or more pieces that are designed to replace joint motion from the implant-bone interface to an interface within the implant. Because the motion occurs within the implant instead of at the implant-bone interface, the implants relieve pain, reduce fibrous tissue formation, and alleviate pscudoarthrosis. Implants can have tailored stiffnesses by modifying the geometry of the contact surfaces within the implant and or by modifying flexures of the implant. Primary fixation of the implant to the bone using screws, blades, or other fixation devices decreases motion at the bone-implant interface. The flexibility of the implant itself decreases motion between the bone and the implant at the bone-implant interface. Additionally, porous and/or roughened surfaces and/or volumes of the implant facilitate boney attachment of the bone to the implant, further reducing the likelihood of movement at the bone-implant interface.

OVERCURE REGIONS FOR 3D PRINTED OBJECTS IN DENTISTRY

Resumen de: US2025178276A1

A method of manufacturing a three-dimensional (3D) object comprises: fabricating one or more support structures; fabricating the 3D object on the one or more support structures, wherein the one or more support structures contact the 3D object at one or more support regions of the 3D object; and overcuring the 3D object at one or more overcure regions of the 3D object, wherein the one or more overcure regions are distinct from the one or more support regions. The 3D object is configured such that after removal of the one or more support structures from the 3D object, one or more support marks remain on the 3D object where the one or more support structures had contacted the 3D object, wherein the one or more overcure regions of the 3D object are configured to project past the one or more support marks.

Customized Urinary Catheters and Methods for Making

Resumen de: US2025177695A1

A method of making a customized catheter for an end user, comprising: capturing images of an end user's urethra; creating a 3D image of the end user's urethra; identifying areas of interest of the end user's urethra; generating a software or computerized model of a customized catheter using the 3D image, wherein the software or computerized model is modified based on the areas of interest; and 3D printing at least a portion of the customized catheter from the model and catheter made by this method

System of multiple interlocking embedment

Resumen de: GB2635903A

An oral dosage tablet for delivery of hydrophobic active ingredients to a patient and method of forming the same are described. The oral dosage tablet includes one or more layers of an active ingredient adjacent one or more layers of a lipid, such as a phospholipid. The layers are alternating and have a thickness of between 0.1 and 0.8 millimeters. The method of forming the tablet includes forming a lipid paste and an active ingredient paste of the respective components and applying alternating layers of each in layers of between 0.1 millimeters to 0.8 millimeters. The oral dosage tablet is subsequently dried and stored until treatment commences.

SYSTEM AND METHOD FOR ENHANCED AEROSOL DRUG DELIVERY DURING HIGH FLOW NASAL CANNULA THERAPY

Resumen de: WO2024026093A1

A system and method for enhanced aerosol drug delivery during high flow nasal cannula (HFNC) therapy. The system comprises a breath enhanced jet nebulizer (BEJN) connected to a high flow medical breathing gas supply supplying breathing gas to the BEJN at flow rates of 5 L/min to 60 L/min, a nebulization gas supply, a drug infusion device that supplies a drug solution to the nebulizer for the delivery of nebulized drug to a patient. All the breathing gas and nebulized drug solution delivered to the patient passes through the BEJN. The rate of drug delivery increases with increases in the flow rate of the medical breathing gas supply and increases in infusion pump flow rates. The drug solution infusion rate is between 5 mL/hour and 50 mL/hour. This system and method enable efficient aerosol drug delivery to patients during HFNC therapy for prolonged periods, improving treatment outcomes.

BIOENGINEERING PATIENT-SPECIFIC 3D-PRINTED CARTILAGE IMPLANTS

Resumen de: WO2024028882A1

The invention related to an implant comprising a scaffold comprising at least one first area characterized by micropores and at least one second area characterized by macropores, wherein said at least one second area is defined by being expected to be exposed to higher pressures and/or forces when compared with said at least one first area, and methods thereof.

Drug-eluting surgical articles and methods of use thereof

Resumen de: GB2635973A

Disclosed herein is a biomaterial and a method of use thereof for treating a condition; the biomaterial comprises a first porous polymer, a second non-porous polymer, and a therapeutic agent. A biomaterial of the disclosure can be, for example, a surgical article. Implantation of a biomaterial disclosed herein into a subject can treat, for example, cancer.

METHODS AND SYSTEMS FOR GENERATING THREE-DIMENSIONAL BIOLOGICAL STRUCTURES

Resumen de: US2022389373A1

One aspect of the invention provides a method of generating three-dimensional biological structures. The method includes: (a) depositing a first layer of a suspension over a substrate, the suspension including a liquid and a plurality of cells; (b) allowing the plurality of cells to attach to the substrate and form a first layer of attached cells; (c) depositing a cell-attachment agent over the first layer of attached cells; and (d) depositing a second layer of the suspension over the cell-attachment agent.

MUSCLE ASSISTANCE MEMBRANE

Resumen de: WO2024022890A1

The invention relates to a muscle membrane intended to be affixed to a muscle of a human or animal body, the membrane being capable of at least partially surrounding the muscle, the muscle comprising fibres covered with an outer tissue, the positioned membrane having a shape that is identical to that of the muscle. The membrane is characterised in that it exhibits anisotropic behaviour so as to reproduce the mechanical behaviour of the muscle, the membrane comprising: - a matrix designed in a biocompatible material having an elasticity similar to that of the outer tissue of the muscle, - one or more reinforcing strips rigidly attached to the matrix, each strip being designed in a biocompatible material having an elasticity similar to that of the fibres it covers and each strip being oriented according to membrane stiffening requirements and according to the expected muscle correction.

INTERPENETRATING POLYMER NETWORKS FOR USE IN SUTURABLE AND FLEXIBLE MATERIALS

Resumen de: AU2023315783A1

An advanced manufactured interpenetrating polymer network (AM-IPN) comprising: a primary polymer network; a secondary polymer network, wherein the secondary polymer network is bonded to the primary polymer network via one or more crosslinks, wherein one or more of the primary polymer network, the secondary polymer network and the one or more crosslinks are printed using a synthetic bioink is disclosed. Methods of making and using are also disclosed.

IMPLANTS COMPRISING A SILICONE FOAM

Resumen de: WO2024026456A1

The present invention relates to a new silicone foam obtained from a blowable crosslinkable silicone composition comprising an organopolysiloxane having at least two alkenyl groups bonded to silicon per molecule, an organosilicon compound having at least two and preferably at least three hydrogen atoms bonded to silicon per molecule, a hydrosilylation catalyst, at least one porogenic agent which is water, a hydrogel, or an aqueous silicone emulsion, at least one chemical blowing agent, and a linear polydimethylsiloxane.

FIXATION OF DYE SOLUTIONS IN MULTI-COLOR INK JET 3D CERAMIC PRINTING

Resumen de: EP4563115A1

Die vorliegende Erfindung betrifft ein Verfahren zum Herstellen einer dentalen Restauration durch Strahldruck, mit den Schritten eines Strahldruckens (S101) einer oder mehrerer Schichten der dentalen Restauration mittels eines keramischen Schlickers; eines Strahldruckens (S102) einer Färbelösung auf die eine oder mehreren Schichten; und eines Auftragens (S103) einer Fixierlösung zum Fixieren der Färbelösung.

PRE-INKED SLIP FOR MULTI-COLOR INK JET 3D CERAMIC PRINTING

Resumen de: EP4563118A1

Die vorliegende Erfindung betrifft ein Verfahren zum Herstellen einer dentalen Restauration durch Strahldruck, mit den Schritten eines Strahldruckens (S101) eines Dentinkerns der dentalen Restauration mittels einer Mehrzahl opaker keramischer Schlicker, die zueinander unterschiedliche Farben aufweisen; und eines Strahldruckens (S102) des Zahnschmelzes der dentalen Restauration mittels eines transluzenten keramischen Schlickers.

SELECTIVE ADJUSTMENT OF HARDNESS AND TRANSLUCENCY IN MULTI-COLOR CERAMIC INKJET 3D PRINTING

Resumen de: EP4563116A1

Die vorliegende Erfindung betrifft ein Verfahren zum Herstellen einer dentalen Restauration durch Strahldruck, mit den Schritten eines Strahldruckens (S101) einer oder mehrerer Schichten der dentalen Restauration mittels eines keramischen Schlickers; und eines Strahldruckens (S102) eines Transluzenzverstärkers oder Opazitätsverstärkers auf die eine oder mehreren Schichten.

SELECTIVE STAINING BY STAINING SOLUTIONS IN 3D PRINTING

Resumen de: EP4563117A1

Die vorliegende Erfindung betrifft ein Verfahren zum Herstellen einer dentalen Restauration (100) durch Strahldruck, mit den Schritten eines Strahldruckens (S101) einer oder mehrerer Schichten der dentalen Restauration mittels eines keramischen Schlickers; und eines Strahldruckens (S102) einer Färbelösung auf die eine oder mehreren Schichten.

INTRAORAL COMPOSITE PRINTER

Resumen de: EP4563114A1

Die Erfindung betrifft das Fachgebiet der Zahnmedizin und bietet ein fortschrittliches Verfahren zur Applikation von fließfähigem Komposit auf Zähne. Hierzu dient ein System, das einen Applikator nutzt, welcher an einer intraoral fixierten Halteschiene angebracht ist. Dies ermöglicht eine präzise und kontrollierte Applikation des Komposits. Die Technologie stellt eine effiziente, automatisierte Lösung bereit, die sowohl für Frontzähne als auch für Backenzähne geeignet ist. Durch den Einsatz von Technologien wie Oberflächenscan, additiver Fertigung und automatisierter Bewegungssteuerung markiert diese Neuentwicklung einen bedeutenden Fortschritt in der Zahnmedizin und hat das Potenzial, die Qualität und Effizienz zahnmedizinischer Behandlungen erheblich zu verbessern.

DOUBLE NETWORKED 3D-PRINTED BIOMATERIALS

Resumen de: WO2024026023A2

A 3D-printed biomaterial is described that comprises a double-networked hydrogel comprising gelatin or gelatin methacryloyl and alginate, and cells. Methods of making the 3D-printed biomaterial by extruding a hydrogel comprising gelatin or gelatin methacryloyl and alginate from a 3D-printer and converting the hydrogel to a double-networked hydrogel by cross-linking the gelatin with a first cross-linking method and cross-linking the alginate with a second cross-linking method are also described. Methods of treating a damaged or diseased blood vessel and testing vasoactive drugs using 3D-printed blood vessels are also described.

一种基于数字化导板引导的前牙分层树脂充填修复方法

Resumen de: CN120078530A

本发明属于口腔修复数字化领域，具体涉及一种基于数字化导板引导的前牙分层树脂充填修复方法。包括以下步骤：S1、获得基牙预备体的三维数字化模型；S2、利用口腔计算机辅助设计软件逐层生成缺损部分的牙本质形态的数字化模型；S3、在最后一层牙体缺损部分牙本质形态的数字化模型上完成牙釉质层形态的设计；S4、设计覆盖缺损牙邻牙的盖壳式导板，并对各盖壳式导板进行编号；S5、将各层模型和导板3D打印出来，并检查导板的就位情况；S6、在各级导板中填充相应的牙本质树脂和牙釉质树脂，将充填树脂的导板复位至口腔牙列，通过光照固化完成分层树脂充填。本发明优化了流程，简化了操作，充分利用数字化技术的优势保证了操作精度。

ADDITIVE MANUFACTURING OF RADIOLOGICAL PHANTOMS

Nº publicación: ES3024086T3 03/06/2025

Solicitante:

STRATASYS LTD
Stratasys Ltd

Resumen de: US2025152121A1

A formulation usable as a modeling material formulation in additive manufacturing of a three-dimensional object and additive manufacturing methods utilizing same are provided. The formulation comprises one or more curable materials; and a radiopaque material, and features, when hardened, a CT number of at least 100 HU at 70 kV. Objects made by the additive manufacturing method utilizing the formulation are usable as radiological phantoms.