Alerta

NEGATIVE POISSON'S RATIO MATERIALS FOR THERMAL AND RADIATION THERAPY SEEDS

Resumen de: US20260041923A1

A biocompatible seed for implantation in tissue of a patient includes an elongated body sized and shaped to be at least partially inserted into the tissue of the patient, in which the body includes a negative Poisson's ratio (NPR) material having a Poisson's ratio of between 0 and −1. The seed can be a thermal seed configured to generate heat responsive to exposure to a magnetic field. The seed can be a seed for brachytherapy that includes an inner layer including a radioactive material and an outer layer including the NPR material.

VALVE ASSEMBLY FOR MEDICAL PROCEDURES

Resumen de: US20260041901A1

The invention relates to a valve used in medical procedures. More specifically the invention relates to an introducer sheath valve used in minimally invasive and conventional surgical procedures. The valve may accommodate a wide range of surgical implement diameters, shapes, and multiple implements without imposing the high frictional forces of known valves.

IMPLANTS COMPRISING A SILICONE FOAM

Resumen de: US20260041814A1

The present invention relates to new implants, especially breast implants, which are bio-durable, biocompatible, which provide a soft tissue feel, and having a reduced density. Said implants comprise a shell and a filling enclosed by the shell, wherein the filling comprises a silicone foam obtained from a blowable crosslinkable silicone composition comprising an organopolysiloxane having at least two alkenyl groups bonded to silicon per molecule, an organosilicon compound having at least two and preferably at least three hydrogen atoms bonded to silicon per molecule, a hydrosilylation catalyst, at least one porogenic agent which is water, hydrogel, or an aqueous silicone emulsion, at least one chemical blowing agent, and a linear polydimethylsiloxane.

METHOD OF MANUFACTURING DIABETIC FOOT PATIENT-SPECIFIC DERMAL REGENERATION SHEET AND DIABETIC FOOT PATIENT-SPECIFIC DERMAL REGENERATION SHEET MANUFACTURED USING THE SAME

Resumen de: US20260041717A1

The specification relates to a method of manufacturing a diabetic foot patient-specific skin regeneration sheet, and a diabetic foot patient-specific skin regeneration sheet. The method includes extracting autologous adipose tissue, removing fibers in the autologous adipose tissue, crushing the autologous adipose tissue, and acquiring an adipose tissue extract by filtrating the crushed autologous adipose tissue.

BIOENGINEERING PATIENT-SPECIFIC 3D-PRINTED CARTILAGE IMPLANTS

Resumen de: US20260041558A1

The invention related to an implant comprising a scaffold comprising at least one first area characterized by micropores and at least one second area characterized by macropores, wherein said at least one second area is defined by being expected to be exposed to higher pressures and/or forces when compared with said at least one first area, and methods thereof.

Additive Manufacturing Part Support and Handling Frame

Resumen de: US20260041436A1

A cutting instrument including an insert and a frame having sidewalls that extend from a base and define a slot. The slot is configured to receive a portion of the insert such that an edge of the insert extends beyond the frame. The sidewalls are configured to shrink around a portion of the insert such that an edge of the insert extends beyond the frame. Additionally, a method for fabricating a cutting instrument including depositing layers of metal powder onto a base and selectively binding the deposited layers of the metal powder onto the base to form a frame attached to the base. Next, placing an insert within the frame such that a portion of the insert extends beyond the frame and the combination of the base, the frame, and the insert forms an in-process assembly.

Breath-Enhanced Jet Nebulizer for HFNC Therapy

Resumen de: US20260041860A1

A system and method for enhanced aerosol drug delivery during high flow nasal cannula (HFNC) therapy. The system comprises a breath enhanced jet nebulizer (BEJN) connected to a high flow medical breathing gas supply supplying breathing gas to the BEJN at flow rates of 5 L/min to 60 L/min, a nebulization gas supply, a drug infusion device that supplies a drug solution to the nebulizer for the delivery of nebulized drug to a patient. All the breathing gas and nebulized drug solution delivered to the patient passes through the BEJN. The rate of drug delivery increases with increases in the flow rate of the medical breathing gas supply and increases in infusion pump flow rates. The drug solution infusion rate is between 5 mL/hour and 50 mL/hour. This system and method enable efficient aerosol drug delivery to patients during HFNC therapy for prolonged periods, improving treatment outcomes.

THREE-DIMENSIONAL RECONSTRUCTION METHOD, ELECTRONIC DEVICE AND STORAGE MEDIUM

Resumen de: US20260045040A1

The present application provides a three-dimensional reconstruction method, an electronic device and a storage medium, the method includes obtaining a first image frame set of an oral cavity in a first state, where the oral cavity in the first state indicates that at least one actual scan body is installed in the oral cavity. A scan body area of each image frame in the first image frame set is identified. Once multiple image frames in the first image frame set are spliced and constructed based on feature information of the scan body area, the target three-dimensional data corresponding to the actual scan body in the oral cavity is obtained.

SYSTEMS AND METHODS FOR SELECTIVE SHAPE TRANSFORMATION OF 3D-PRINTED MATERIALS

Resumen de: US20260042889A1

Shape-restoring materials, as well as techniques for generating shape-restoring materials, are described. An example method includes generating a construct by exposing, to UV-visible light, a resin comprising a globular protein, a water-soluble co-monomer, light-to-heat converting nanoparticles, water, and a photoinitiator. At least a portion of the water is removed from the construct. The construct is converted from a first shape to a second shape by applying a force to the construct. The construct is reverted to the first shape in response to being exposed to NIR light, due to the absorption of the NIR light by the nanoparticles.

FABRICATION METHOD AND SYSTEM FOR LPBF MAGNESIUM-ALLOY TISSUE-ENGINEERING SCAFFOLD WITH SMOOTH INNER SURFACE

Resumen de: WO2026031699A1

Provided in the present invention are a fabrication method and system for an LPBF magnesium-alloy tissue-engineering scaffold with a smooth inner surface. The method comprises: step S1, scanning a porous scaffold, and performing screening to obtain infill scanning parameters, which can achieve the greatest density, wherein the scanning comprises single-pass contour scanning and single infill scanning; step S2, on the basis of said infill scanning parameters, optimizing a contour scanning strategy; step S3, acquiring a corresponding molten-pool size, and using the optimized contour scanning strategy to adjust a spot compensation value; and step S4, on the basis of the contour scanning strategy and the adjusted spot compensation value, fabricating a magnesium-alloy tissue-engineering scaffold. In the present invention, the defects of powder adhesion and dross formation in a complex porous structure which seriously affect the inner surface roughness and the scaffold performance are eliminate in situ during fabrication, such that the fluidity, fatigue resistance and corrosion resistance of a porous scaffold are improved, cumbersome post-processing procedures are simplified, and the production cost is reduced, thereby achieving the concept of green production.

SPINAL IMPLANTS WITH CUSTOM DENSITY AND 3-D PRINTING OF SPINAL IMPLANTS

Resumen de: EP4691507A2

In some embodiments, a spinal implant (10, 110, 210, 310, 400) is provided and includes a body portion defining a longitudinal axis. The body portion includes a distal end portion, a proximal end portion, opposed side surfaces that extend between the distal and proximal end portions, and top and bottom surfaces configured and adapted to engage vertebral bodies. The top and bottom surfaces have a surface roughness between 3-4 µm. A cavity extends through the top and bottom surfaces defining a surface area that is at least 25% of a surface area of the top surface or the bottom surface. First orifices (24, 124, 224, 324, 426a) are defined through the top surface and second orifices (34, 134, 234, 334, 426b) are defined through the bottom surface. The second orifices are connected to the first orifices by a plurality of channels.

ADDITIVE MANUFACTURING PART SUPPORT AND HANDLING FRAME

Resumen de: EP4691381A1

A cutting instrument including an insert and a frame having sidewalls that extend from a base and define a slot. The slot is configured to receive a portion of the insert such that an edge of the insert extends beyond the frame. The sidewalls are configured to shrink around a portion of the insert such that an edge of the insert extends beyond the frame. Additionally, a method for fabricating a cutting instrument including depositing layers of metal powder onto a base and selectively binding the deposited layers of the metal powder onto the base to form a frame attached to the base. Next, placing an insert within the frame such that a portion of the insert extends beyond the frame and the combination of the base, the frame, and the insert forms an in-process assembly.

DENTAL-TREATMENT INDEX, DENTAL-TREATMENT INDEX FIXING HOLDER, DENTAL-TREATMENT SET, METHOD FOR GENERATING THREE-DIMENSIONAL DATA OF DENTAL-TREATMENT INDEX, AND DATA FOR PREPARING DENTAL-TREATMENT INDEX

Resumen de: EP4691414A1

Provided is a dental-treatment index that enables high-quality tooth crown restoration regardless of the skill of a practitioner. A dental-treatment index 10 according to the present invention is composed of a material through which light transmits, and has two fixing outer surfaces 13 and a tooth-shaped hole 14 provided in an internal surface 11a between said two fixing outer surfaces 13. Each of the fixing outer surfaces 13 is provided with a guide part 13a. A dental-treatment index fixing holder 20 is composed of a material through which light transmits, and has two holder lateral surface parts 22 that are coupled to each other. In the two holder lateral surface parts 22, fixing inner surfaces 23 facing each other have guided parts 23a provided thereto.

INVERTED CONTACT-AIDED ROLLING ELEMENT MECHANISMS AND DEVICES

Resumen de: WO2024211902A1

Inverted contact-aided rolling element mechanisms and devices are discussed herein. In various embodiments, the contact-aided compliant mechanism includes a first rigid component, a second rigid component, a first flexible component, a second flexible component, each of the first and second flexible components comprising a first end, a second end, and a third end, and the first and second flexible components disposed between the first and second rigid components.

IMPLANT

Resumen de: AU2024241734A1

This invention relates to an implant (10), including a support arrangement (12) manufactured from a form of a porous material, for receiving and supporting stem cells (14) in a supported condition, for receiving a medium in the form of a neural basal and neural induction medium mixture (20) and the support arrangement (12) being shaped and sized to conform to and be received complementally by an implant zone (16). The implant zone (16) being a space defined by an excised portion of a subject's spinal cord (18). The neural basal and neural induction medium mixture (20) provides nutrients for the development of the stem cells (14) and the growth factors, in form of neurotrophin 3, neurotrophin 4 and brain-derived neurotrophic factor (BDNF) encourage and control development of the stem cells (14), the growth factors typically being constituents of the medium mixture (20).

AUTOMATIC DESIGN OF CUSTOM EAR DEVICES

Resumen de: WO2024200441A1

Described herein is a computer-implemented method for constructing in the form of designing in a virtual environment a custom ear device in an automated process utilizing a trained neural network. The computer-implemented method described is configured to allow for changing the output form the neural network to create change to an automatic generated custom ear device design. Furthermore, described herein is a system utilizing a processor running the method described herein to automatically generate virtually constructed custom ear devices that may be modified to adjust for any incorrect outputs generated by a neural network.

ORTHODONTIC APPLIANCE SYSTEMS AND METHODS OF MAKING SAME

Resumen de: WO2024206597A1

An orthodontic appliance system for orthodontic treatment of teeth. The system includes a template with a cavity. An attachment is removably received in the receptacle and has a surface including a bonding surface. A method of manufacturing includes constructing a scaffold assembly including a base and placing a template in contact with the scaffold assembly. The method includes inserting the attachment into the receptacle. During separating, the attachment remains coupled to the template in the receptacle. A method of manufacturing includes providing a mold of the patient's teeth. The mold including at least one projection and a through-passage. The method includes placing a container of dental composite in fluid communication with the through-passage, placing a template over the at least one projection, injecting dental composite from the container through the through-passage and into the receptacle, and removing the template from the at least one projection with the filled receptacle.

NOVEL PROCESS

Resumen de: WO2024201321A1

The present invention relates to a process for obtaining a dental prosthesis comprising a crown and tooth root. Said process comprises at least one step of directing undifferentiated cells or keratinocytes and at least one three-dimensional printing step, preferably 3D bioprinting of the dental prosthesis. Furthermore, the invention regards the dental prosthesis obtained with the process and a bioink suitable for three-dimensional printing (3D), preferably suitable for 3D bioprinting.

CONTROL OF HEATING AND COOLING IN 3D BIOPRINTING

Resumen de: GB2629895A

3D printing assembly 10, suitable for bioprinting, the assembly including an enclosure 100 defining an enclosure internal area 101, a printer 200 enclosed within the internal area, the printer comprising a printer bed 240, the enclosure comprising plural sides 110, one or more of said sides having at least one temperature regulator element 112 in or on the respective side 110, wherein the or each temperature regulator element is arranged to introduce heat energy into, and/or remove heat energy from the internal area 101, and wherein the printer bed has at least one bed temperature regulator element 242 in or on the printer bed further arranged to introduce heat energy into, and/or remove heat energy from the printer bed, the sides formed from spaced apart panels and the temperature regulator element is mounted between the panels. The temperature control may be aided by air flow from a fan 130 or the like. The wall and/or bed temperature regulator element(s) maybe Peltier type devices. Bioink storage 210 maybe provided. Plural temperature sensors (TP1,TP2 and TP3) maybe provided. An enclosure for enclosing a 3D printer and a controller for a 3D printer are also provided.

POSTERIOR BITE INTERFERENCE ELEMENTS

Resumen de: US2025375269A1

The present disclosure discusses techniques for fabricating bite interference elements within polymeric dental appliances. The techniques disclose at least one polymeric shell that includes a number of cavities shaped to fit over a patient's teeth. The polymeric shell includes an occlusal appliance surface shaped to fit over an occlusal tooth surface of the patient. One or more bite interference elements are formed within the occlusal appliance surface, and each bite interference element includes a partially disc-shaped feature extending radially away from the occlusal tooth surface when worn by the patient.

TECHNIQUES FOR AUTOMATED MARKING OF DENTAL APPLIANCES

Resumen de: MX2025011659A

The present disclosure discusses techniques for marking a dental appliance. A dental model and dental appliance are positioned onto a conveyor tray, which is transported to a scan station. The dental model and conveyor tray each include an identifying code. The scan station includes a camera and barcode reader to read the identifying codes on the dental model and conveyor tray, and these codes are associated with one another. The conveyor tray then moves to a marking station where a barcode reader reads the code on the conveyor tray, and then marks the dental appliance with the appropriate marking.

A BIOACTIVE POLY(LACTIC-CO-GLYCOLIC ACID) (PLGA) MATERIAL, RELATED PRINTED STRUCTURE AND RELATED METHODS THEREOF

Resumen de: WO2024181920A1

There is provided a regenerative material for treatment of wounds, the material comprising: (i) a base poly(lactic-co-glycolic acid) (PLGA); (ii) a bioactive poly(lactic-co-glycolic acid) (PLGA) copolymer; and (iii) pores patterned on said material. Also provided are a medical device comprising said regenerative material, medical uses of said regenerative material, and a method of preparing said regenerative material.

光硬化性組成物

Resumen de: CN118414365A

The photocurable composition may include a photocurable resin and a photoinitiator. The photocurable composition may typically have a shear viscosity of less than 1 Pa.s at a shear rate of 50 s-1 at 100 DEG C, and may typically include a first prepolymer, a second prepolymer, and a reactive diluent.

微細構造の付加製造

Resumen de: CN120659679A

The present invention relates to an additive manufacturing method of a microstructure (10) for selective transmission of X-ray radiation or gamma-ray radiation, the method comprising: depositing (110) a powder layer on a build plate or on a layer from at least one previous manufacturing step on the build plate wherein the powder layer comprises a high Z material powder. In addition, the method includes selectively melting (120) and solidifying the powder to form a septum wall structure (20) by scanning an electron beam over the powder layer in a sequence of spots to sequentially expose a plurality of spots (40) on the powder layer to electron beam spots. The electron beam spot has a size of at most 150 mu m in diameter, preferably at most 75 mu m in diameter, and more preferably at most 50 mu m in diameter. The high Z material powder includes a high Z material having an atomic number Z of at least 40 and preferably of at least 70. The invention also relates to a microstructure for the selective transmission of X-ray radiation or gamma-ray radiation, said microstructure being obtained by said method, and to an imaging component comprising such a microstructure. The invention also relates to a method for manufacturing the imaging component.

一种虎杖苷腱骨修复梯度仿生支架及其制备方法

Nº publicación: CN121490141A 10/02/2026

Solicitante:

四川大学华西第四医院（四川大学华西职业病医院）

Resumen de: CN121490141A

本发明公开了一种虎杖苷腱骨修复梯度仿生支架及其制备方法，将纳米羟基磷灰石（nHAP）/聚己内酯（PCL）复合材料与含有虎杖苷（PLD）脂质体的生物水凝胶两种材料，通过3D打印设计与制备构建成多分区结构，以此满足腱骨愈合的复杂要求。其中nHAP/PCL复合材料良好机械性能匹配肌腱受力环境，作为支架的力学框架。nHAP的引入能有效促进骨损伤区域的愈合，缓释PLD脂质体水凝胶的构建可以有效逆转腱‑骨界面的纤维化。本发明通过3D打印技术所构建的缓释虎杖苷的梯度仿生支架能为腱骨愈合带来全新的治疗方案。