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MULTIMATERIAL BIOPRINTING DEVICE

Resumen de: WO2025215267A1

The invention relates to a multimaterial bioprinting device, which comprises a rotary platform (1) on which a plurality of vessels (2) is arranged, the vessels containing different biomaterials for printing, such that the rotary platform (1) is designed to rotate each vessel (2) to a printing area (3); an arm (4) with a support (5) in the printing area, such that the arm (4) is vertically moveable; a digital light processing system designed to direct a light towards the printing area (3); and a processor (11) configured to manage the vertical movement of the arm (4) and to manage the light of the digital light processing system, wherein the printing area (3) is designed such that the light of the digital light processing system makes contact with the extracted biomaterial through the support (5) of the vessels (2).

SYSTEM FOR CUSTOM IMPLANT DESIGN AND INSTRUMENTATION

Resumen de: WO2025217154A1

Systems and methods include a component of a bone implant that includes a patient specific bone contacting surface and, optionally, at least one protrusion adjacent to or extending from the patient specific bone contacting surface. The at least one protrusion is configured for engaging a bone preparation in the bone. To prepare the bone for receiving the component, one or more cutting tool templates may be used. The one or more cutting tool templates may be fabricated to have a patient specific bone contacting surface that engages the bone that is to receive the implant component. A cutting tool is engaged in one or more of one or more slots defined by the cutting tool template(s) to remove surface portions of the bone to create the bone preparation for engaging the protrusion. The patient specific bone contacting surface of the component engages the bone.

PORTABLE PRINTER

Resumen de: US2025319710A1

A portable printer including a body accommodating a cartridge including a printing material, a nozzle configured to deliver the printing material to a target, a seating part facing a surface of the target, a roller on a lower portion of the body such that the body is moved on the surface of the target, and a printing adjustment part configured to maintain a height difference between the nozzle and the roller in a first height or a second height, wherein the printing adjustment part is configured to preset a height difference between the nozzle and the roller.

SYSTEM FOR EDGE CASE PATHOLOGY IDENTIFICATION AND IMPLANT MANUFACTURING

Resumen de: WO2024151669A1

Systems and methods for identifying edge case pathologies for inspection in a patient-specific orthopedic implant procedure are disclosed. A system can analyze patient data, such as implant data, pre-operative data, post-operative data, or implant manufactured data to identify edge case pathologies in the patient data that can affect installing an implant in the patient. Based on the type of edge case pathology, the system sends a notification for a human, such as a healthcare provider, to review the patient data prior to installing the patient-specific orthopedic implant in the patient.

NOVEL FIBRINOGEN-BASED BIOINKS FOR WOUND HEALING AND TISSUE REGENERATION

Resumen de: EP4631538A1

The present invention relates to a bioink formulation comprising fibrinogen and a glycosaminoglycans (GAGs)/collagen (Col) matrix, preferably comprising human cells, preferably human mesenchymal stem cells (hMSCs), keratinocytes and/or human dermal fibroblasts (hDFs), and its use in the treatment of tissue or bone injuries or damages, specifically skin tissue injuries or damages.

Patient-specific humeral head guide device and systems and method for manufacturing same

Resumen de: GB2640326A

A patient-specific humeral head guide device may be designed and manufactured to contour the shape of a patient’s humeral head from medical images. A humeral shaft is identified and two or more points along the shaft used to define a humeral axis along with a colinear point based on a centre of lesser tuberosity. A humeral sagittal plane is identified, as is a coplanar anterior axis. A resection plane is also identified based on the sagittal plane and an angle of inclination from the longitudinal axis. Computer aided manufacturing (CAM) printing instructions are generated to print a resection channel for a cutting device. The humeral head contouring body may be of loop style and may have an extended footprint to contour a portion of lesser tuberosity. There may be fixation wire channels, at least one of which permits visual confirmation that a patient forearm aligns with an anterior axis. There may be a channel for receiving an intermedullary reamer aligned to a humeral canal centre. The CAM instructions may include G-code that causes a three-dimensional (3D) printer to manufacture a patient-specific humeral head guide device and for other various portions of the device.

3D FAT TISSUE STRUCTURE, PRODUCED USING LIGHT-BASED STRUCTURING CURING, FOR USE AS A BREAST IMPLANT

Resumen de: CN120322257A

The present invention relates to a 3D adipose tissue scaffold for use as a breast implant for surgical, therapeutic, prophylactic or aesthetic recovery, construction or replacement of human breast tissue, in which the 3D adipose tissue scaffold has a matrix consisting of a biocompatible polymer, the matrix being colonized with a plurality of biological cell types, wherein the colonization of the plurality of cell types is carried out during the formation of a matrix made of a biocompatible polymer, accompanying the formation of a network of vascular structures within the 3D adipose tissue scaffold. Light-based structured curing of a photo-polymerizable or photo-crosslinkable liquid is used to build a matrix composed of a biocompatible polymer. The invention also relates to the use of a 3D adipose tissue scaffold as a human breast implant, the 3D adipose tissue scaffold having a matrix consisting of a biocompatible polymer, the matrix being colonized with a plurality of cell types, the colonization of the plurality of cell types being carried out in the process of forming the matrix consisting of a biocompatible polymer, the present invention relates to a 3D adipose tissue scaffold, in which a network of vascular structures is formed within the 3D adipose tissue scaffold, characterized in that a matrix consisting of a biocompatible polymer is constructed by means of light-based structured curing of a photopolymerizable or photocrosslinkable liquid.

用于制备再生型植入体的激光增材制造系统

Resumen de: CN120772553A

本发明提供用于制备再生型植入体的激光增材制造系统，属于激光增材制备技术领域。该系统包括精细动态聚焦模块、成形模块、烟尘净化模块和风场调控模块；精细动态聚焦模块包括：光学聚焦单元，包括同轴设置的激光器、变倍扩束镜和振镜组件及场镜；水冷单元，其位于变倍扩束镜与振镜组件之间，包括水冷遮光孔板与外设的冷水机；动态变焦单元，通过驱动场镜位移形成混合变焦系统实现动态变焦；成形模块包括：成形缸；粉末床；加热器阵列，安装于成形缸内部侧壁与顶部并环绕粉末床的加热器阵列；温度传感器阵列，分布于粉末床上；风场调控模块在成形缸内部形成高温强迫环流。本发明解决了现有技术中再生型植入体激光增材制造的精细微孔制备难题。

一种丙烯酰胺化阿仑膦酸钠修饰羟基磷灰石及其制备方法和应用

Resumen de: CN120771340A

本发明公开了一种丙烯酰胺化阿仑膦酸钠修饰羟基磷灰石(HAP@AM)及其制备方法和应用，涉及骨修复支架材料技术领域，所述丙烯酰胺化阿仑膦酸钠修饰羟基磷灰石为表面接枝有甲基丙烯酰胺化阿仑膦酸钠的纳米羟基磷灰石；丙烯酰胺化阿仑膦酸钠修饰羟基磷灰石中甲基丙烯酰胺化阿仑膦酸钠的接枝率为1～5wt％，丙烯酰胺化阿仑膦酸钠修饰羟基磷灰石的平均粒径为200～800nm，Zeta电位为‑12～‑22mV。本发明制备的HAP@AM在GelMA中具有优异的分散性与稳定性，与GelMA制成3D打印墨水，还具有优异的打印性能和力学性能。

原位润滑3D打印Janus骨软骨修复支架及其制备方法

Resumen de: CN120771351A

本发明涉及一种原位润滑3D打印Janus骨软骨修复支架及其制备方法，其中，所述支架由3D打印制得，包括软骨下骨层及软骨层，其中：所述软骨下骨层由GelMA和NAGA负载nHA制得，以促进骨愈合；所述软骨层配置两性离子单体，实现原位润滑。本发明可通过软骨层支架结构润滑改性实现原位润滑，通过软骨下骨层支架负载羟基磷灰石促进骨愈合。

假肢打印方法、装置、电子设备、存储介质及计算机程序产品

Resumen de: CN120770988A

本申请公开了一种假肢打印方法、装置、电子设备、存储介质及计算机程序产品，其中，方法包括：获取第一用户的第一生理数据组；调用第一人工智能模型对第一生理数据组进行处理，得到第一约束参数组；第一人工智能模型用于基于输入的生理数据组推荐约束参数组；约束参数组表征该输入的生理数据组对应的机械性能要求相关的约束；以第一约束参数组作为约束，调用生成式设计算法对第一生理数据组进行处理，得到第一设计参数组；生成式设计算法用于基于输入的生理数据组生成满足对应的舒适度要求的设计参数组，且设计参数组中包含假肢的多个设计参数；基于第一设计参数组与切片参数组，生成第一文件，并输出第一文件至三维打印装置。

三维自组装支架

Resumen de: US2025313799A1

A three-dimensional scaffold includes a plurality of scaffold elements. Each scaffold element includes at least one peptide component, which comprises a stretch of amino acids, and at least two nucleic acid components. The at least two nucleic acid components of the plurality of scaffold elements are configured to mediate self-assembly of the three-dimensional scaffold.

神経導管

Resumen de: CN120513057A

The invention relates to a nerve conduit for connecting an impaired nerve ending to a target site. In particular, the present invention relates to nerve conduits that support nerve injury repair and motion control and/or reduce the risk of development of injured nerve ending neuroma. Thus, a nerve conduit (10) connecting an impaired nerve ending (26) to a target site (28) is proposed, the nerve conduit (10) comprising an elongated body (12) formed by a wall (22) and comprising a central portion (14) defining a lumen (16) and end portions (18, 19) defining respective openings (20, 20 ') to the lumen (16), the end portions (18, 19) being arranged adjacent to the central portion (14) and located at longitudinally opposite ends of the elongated body (12). One tip portion (18) is configured as an insertion portion configured to be inserted into a corresponding nerve ending (26). According to the invention, the other end portion is configured as a nerve ending outlet portion (19) wherein the outer diameter of the wall defining the outlet portion (19) is greater than the outer diameter of the wall defining the central portion (14).

3D 3D Printer-Based System for Manufacturing and Verifying Dental Orthodontic Appliances

Resumen de: KR102870460B1

본 발명은 3D 프린터를 활용한 치과 교정 장치 제조 및 검증 시스템에 있어서, 환자의 구강 내부를 3차원으로 스캔하여 디지털 구강 데이터를 생성하는 스캐닝부; 상기 디지털 구강 데이터를 기반으로 교정 장치의 3차원 모델을 생성하는 설계부; 상기 3차원 모델에 따라 수지 재질의 상기 교정 장치를 적층 제조하는 3D 프린팅부; 상기 3D 프린팅부로부터 출력된 상기 교정 장치의 형상 및 치수 정밀도를 검증하기 위하여, 출력된 상기 교정 장치의 표면을 3차원으로 스캔하는 검증 스캐닝부; 상기 검증 스캐닝부로부터 획득한 출력 형상 정보와 상기 설계부에서 생성된 3차원 모델 간의 차이를 정량적으로 분석하여, 허용 오차 범위를 초과하는 경우 재설계를 지시하는 정밀도 판별부를 포함하고, 상기 정밀도 판별부는, 상기 출력 형상 정보를 다점 클라우드 형식으로 분석하고, 상기 출력 형상 정보와 상기 설계부에서 생성된 3차원 모델 간의 차이로부터 오차 분포를 산출하며, 상기 오차 분포에 기초하여 보정 파라미터를 생성하고, 생성된 상기 보정 파라미터를 상기 설계부에 제공하여, 상기 설계부가 상기 보정 파라미터를 반영한 새로운 출력 모델을 생성하고, 상기 새로운 출력 모델이 상기 3D 프린팅부로 전송되어, 상기 3D 프린�

Anthropomorphic breast phantom and method for making the same

Resumen de: KR20250148203A

실제 인체 유방 엑스선 영상과 유사한 영상을 제공할 수 있고, 유방 의인화 팬텀을 이용하여 AEC의 농도 조절인자를 최적화하여 자동노출 관전류량을 39.4%~43.4% 감소시킬 수 있는 유방 의인화 팬텀 및 그 제조방법이 개시된다. 상기 유방 의인화 팬텀 제조방법은 표준 엑스선 유방 DICOM(Digital Imaging and Communications in Medicine) 영상 파일을 디지털라이즈드 리서페인(digitalized lithophane) 기술을 이용하여 3D 프린팅을 위한 유방 의인화 팬텀의 3D 모델의 STL 파일을 만드는 STL파일 획득과정, 상기 STL 파일 형식의 상기 유방 의인화 팬텀 3D 모델을 슬라이싱하여 3D 프린터가 출력할 수 있도록 3D 프린터의 명령어인 G-code를 생성하는 G-code 생성과정 및 상기 G-code에 따라 상기 유방 의인화 팬텀 3D 모델을 3D 프린터로 출력하여 유방 의인화 팬텀 본체를 만드는 프린팅 과정을 포함하는 구성을 가진다.

3차원 광조형용 경화성 조성물 및 그 제조방법, 3차원 광조형물의 제조방법 및 치과용 수복물의 제조방법

Resumen de: AU2024218051A1

The present invention provides a curable composition for three-dimensional stereolithography, the curable composition being used in a vat photopolymerization method and containing 100 parts by mass of a polymerizable monomer component (A), 40 parts by mass to 400 parts by mass of an inorganic filler (B) that is composed of a single kind or plural kinds of inorganic particulate matter, and 0.01 part by mass to 5 parts by mass of a photopolymerization initiator (C), wherein: 80% or more of all primary particles that constitute the inorganic filler (B) have a particle diameter of 0.05 µm to 5.0 µm; and a sample, which is formed of this curable composition for three-dimensional stereolithography and has a thickness of 0.5 mm, has a transmittance of 1.00% to 50.00% with respect to activation light. The present invention also provides a method for producing this curable composition for three-dimensional stereolithography. The present invention also provides a method for producing a three-dimensional stereolithographic model and a method for producing a dental restoration, each using this curable composition for three-dimensional stereolithography.

PHANTOM BRAIN MODEL FORMING METHOD AND PHANTOM BRAIN MODEL

Resumen de: KR20250148068A

본 실시예는 팬텀 뇌 모델 형성 방법으로, 상기 방법은: 주입 전극을 형성하는 단계를 포함하고, 상기 주입 전극을 형성하는 단계는: 기판에 복수의 전극들 및 상기 전극들과 연결된 선로들을 형성하는 단계; 상기 복수의 전극들과 상기 선로들을 노출하는 봉지 패턴을 형성하는 단계; 노출된 상기 선로들과 외부 회로를 연결하는 외부 연결 선로를 전기적으로 연결하는 단계 및 상기 복수의 전극들을 외부로 노출하는 프로브 홀(probe hole)들을 포함하는 커버 부재를 형성하여 결합하는 단계를 포함한다.

情報処理装置、印刷装置、方法およびプログラム

Resumen de: JP2025155076A

【課題】服用者の薬の飲み忘れを防ぎ、且つ、複数ある服用タイミングのうち、特に注意すべき服用タイミングを服用者に認識させること。【解決手段】情報処理装置は、少なくとも１つのプロセッサを備える。少なくとも１つのプロセッサは、入力される複数の薬の服用情報に基づいて、複数の薬のうちの少なくとも１つを服用するタイミングである複数の服用タイミングのうち、所定の条件を満たす服用タイミングと、服用タイミングにおいて複数の薬のなかで服用すべき薬を服用者に認識させる情報である注意喚起情報と、を対応付け、対応付けられた注意喚起情報と服用タイミングとを出力装置に出力する。【選択図】図６

一种牙齿3D打印机用可调式操作平台

Resumen de: CN223431997U

本实用新型涉及3D打印设备技术领域，提供了一种牙齿3D打印机用可调式操作平台，包括：安装板，驱动电机，通过架体设置在所述安装板的表面上；还包括：两个槽口，开设在所述安装板表面的对称处，其中一个所述槽口的内部设置有螺纹杆一，所述螺纹杆一的一端设置在驱动电机的输出端表面上。本实用新型，通过旋转滑槽内部的螺纹杆二，带动滑块在滑槽的内部进行移动，使得连接板表面的安装架进行横向移动，带动放置板对准打印机本体，通过驱动电机工作，带动输出端螺纹杆一表面的U型架沿着导向杆进行横向移动，使得打印的牙齿对准打印机本体的输出端，配合电动推杆工作，带动移动板表面的安装座进行纵向移动，完成打印机本体的打印工作。

Apparatus and Method of Producing Cartilage Soft Tissue Support and Cartilage Soft Tissue Support of Prepare by the same

Resumen de: KR20250145323A

본 발명은 유연한 생분해성 재질로 형성되어 연골을 지지할 수 있는 연골 연부조직 지지체 제조 장치 및 방법 및 이에 의해 제조된 연골 연부조직 지지체에 대한 것이며, 구체적으로 연골 연부조직 지지체 제조 장치에 있어서, 연골 연부조직 지지체의 패턴 및 형상을 3D 모델링으로 설계하는 설계부와 설계부와 연결되며, 성형재료를 공급하는 공급부와 공급부에 형성되며, 설계부에서 설계한 패턴 및 형상으로 이동함에 따라 성형재료를 출력하는 출력부와 출력부의 이동속도, 압력, 온도 중 선택된 하나를 제어하는 제어부를 구비한다.

3D Functional wrist protector with 3D printed pad to prevent and alleviate carpal tunnel syndrome

Resumen de: KR20250146085A

본 발명은 손목터널증후군 예방 및 완화를 위한 3D 프린팅 패드가 마련된 기능성 손목보호대에 관한 것으로서, 사용자의 손과 손목에 착용할 수 있도록 형성되어 있는 착용부와, 상기 착용부의 상부와 하부에 각각 형성되어 손목이 꺾이지 않은 상태로 지지될 수 있도록 하는 지지부를 포함하는 것을 특징으로 한다.

Methods for preparing porous scaffold for cell culture comprising marine-derived protein

Resumen de: KR20250146682A

본 발명은 (a) 해양 생물 유래 젤라틴과 알지네이트를 증류수에 녹여 젤라틴-알지네이트 혼합용액을 제조하는 단계; (b) 상기 젤라틴-알지네이트 혼합용액에 광개시제와 전자수용체를 첨가하여 전구체 용액을 준비하는 단계; (c) 상기 전구체 용액의 광가교를 유도하여 하이드로젤을 형성하는 단계; (d) 상기 하이드로젤의 이온결합을 유도하여 이중 가교 구조체를 형성하는 단계; 및 (e) 상기 이중 가교 구조체를 유기산 용액에 침지시켜 알지네이트를 제거함으로써 하이드로젤 다공성 구조체를 형성하는 단계;를 포함하는 3D 다공성 세포 지지체의 제조방법에 관한 것이다. 이에 의하여, 본 발명의 해양 생물 유래 단백질을 이용한 3D 다공성 세포 지지체의 제조방법은 근육세포와 유사한 형태로 세포배양이 이루어질 수 있을 뿐 아니라 세포의 부착이 용이하고 증식이 균일하게 이루어져 3차원으로 세포 배양을 매우 효율적으로 수행할 수 있으며, 해양 생물을 식재료로 이용할 때 발생하는 생선 비늘, 생선 껍질 등의 폐기물로부터 제조되는 젤라틴 재료를 활용하여 환경오염을 줄이고 비용도 절감할 수 있다.

METHOD FOR PRODUCING A DENTAL RESTORATION

Resumen de: KR20240080147A

The present invention relates to a method for manufacturing a dental restoration, comprising the steps of: (s101) determining a first space area of a dental restoration subject to a higher load than a second space area of the dental restoration; and (s102) manufacturing the dental restoration in the first space area with a different manufacturing material from the second space area.

SYSTEMS AND METHODS FOR OPTIMIZED PATIENT SPECIFIC TISSUE ENGINEERING VASCULAR GRAFTS

Resumen de: US2025009937A1

It has been established that optimizing cell seeding onto tissue engineering vascular grafts (TEVG) is associated with reduced inflammatory responses and reduced post-operative stenosis of TEVG. Cell seeding increased TEVG patency in a dose dependent manner, and TEVG patency improved when more cells were seeded, however duration of incubation time showed minimal effect on TEVG patency. Methods of engineering patient specific TEVG including optimal numbers of cells to maintain graft patency and reduce post-operative stenosis are provided. Closed, single-use customizable systems for seeding TEVG are also provided. Preferably the systems are custom-designed based on morphology of the patient specific graft, to enhance the efficacy of cell seeding.

一种距下关节固定装置

Nº publicación: CN223416347U 10/10/2025

Solicitante:

上海市第六人民医院上海朗络医疗科技有限公司复旦大学义乌研究院

Resumen de: CN223416347U

本实用新型提供了一种距下关节固定装置，属于医疗器械技术领域。该距下关节固定装置包括足托，足托套设在穿戴者的足跟部；足托包括底板以及设置在底板两侧顶端的第一侧板与第二侧板，第一侧板与第二侧板相对向内折弯，第一侧板与第二侧板顶端分别向底板方向凹陷形成有凹槽；第一侧板与第二侧板与穿戴者的脚踝相贴合。该距下关节固定装置结构简单，适应性好，能充分开放前足活动空间，减少穿戴不适感，达到用户自我锻炼重塑肌肉韧带及行走发力问题，安全性高。