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201
resultados
Última actualización
15/06/2025 [07:16:00]
Resultados 25 a 50 de 201
Resumen de: CN120114644A
本发明公开了一种具有离子释放和光热介导双模式抗菌的3D打印聚乳酸复合支架的制备方法。该方法将聚乳酸(PLA)颗粒、氮化硼(BN)和氧化锌(ZnO)通过溶剂铸造的方式混合搅拌均匀制备成复合片状材料，使用单螺杆挤出机将复合片状材料制备成复合丝材，将制备的复合丝材通过熔融沉积成型(FDM)3D打印技术制备聚乳酸/氮化硼/氧化锌(PLA/BN/ZnO)复合支架，之后在其表面涂覆了负载了银纳米颗粒聚多巴胺涂层，最后得到具有离子释放和光热介导双模式抗菌的3D打印聚乳酸复合支架。通过本发明提出的方法制备的支架具有PDA涂层光热介导抗菌和外层银离子释放、内层锌离子释放梯度抗菌双模式抗菌功能，同时氮化硼的加入使得支架促成骨性能得到提升。本发明为骨缺损修复过程中常见的细菌感染问题提供了一种有前景的解决方案。
Resumen de: CN120114650A
本发明提出了一种负载干细胞外基质的3D打印材料及其制备方法和应用，属于生物材料技术领域。包括如下重量份的组分：改性丝素蛋白肽‑聚乳酸树脂100‑150份、负载干细胞外基质纳米粒子20‑40份、缓释壳聚糖微球10‑20份、透明质酸钠150‑200份、明胶50‑100份。本发明制得的负载干细胞外基质的3D打印材料与传统化学合成高分子支架相比具有更好的生物相容性，安全性高，力学性能佳，促进了细胞的粘附生长，实现了药物的缓慢均匀释放，多信号调节软骨生长和骨化，促进了软骨修复，具有广阔的应用前景。
Resumen de: US2023271353A1
A method for producing molded parts from a sinterable mixing compound using a cold casting mold having a cavity that corresponds geometrically to the molded part and at least one opening into the cavity, wherein the mold is additively constructed from a starting material, in particular a 3D printing method using a 3D printer, and wherein the cavity is created on the basis of a digital data set, in particular based on a three-dimensional model of the oral cavity of a patient. The cavity is filled via the opening with the sinterable mixing compound, curing and/or solidifying the mixing compound, wherein gases and/or liquids contained in the mixing compound are discharged from the cavity via the opening, thermally and/or thermochemically decomposing the mold at a temperature from 200° C. to 2500° C. and sintering the mixing compound to hardness at a temperature from 900° C. to 2500° C. until a molded part is obtained.
Resumen de: CN120093986A
本申请提供的生物打印墨水、生物材料三维支架及制备方法，合成水凝胶颗粒前驱体；对所述水凝胶颗粒前驱体进行冷冻干燥得到水凝胶干粉；将细胞悬液载体与细胞悬液混合以形成缝隙胶；将所述缝隙胶与所述水凝胶干粉搅拌分散以得到所述生物打印墨水。本申请提供的生物打印墨水，具有相容性好、易于打印操作的生物材料，可以按需在体外构建人体或动物的组织或器官，提供利于细胞生长的三维支撑材料。该材料可以精确打印高密度的细胞，有效地控制细胞在三维支架中的空间分布(不发生细胞沉降)，提高细胞在三维支架上的粘附率，解决细胞打印的成型性和生物相容性问题。
Resumen de: CN222942498U
本实用新型提供了一种软骨修复支架，软骨修复支架的支架本体的内部设有空腔，支架本体的表面设有开口，开口将空腔和支架本体的外部空间连通；支架本体上设有若干微孔，至少部分微孔连通空腔和支架本体的外部空间。本实用新型的软骨修复支架解决了相关技术中的软骨修复支架使用灵活性差的技术问题。
Resumen de: AU2023330160A1
The present disclosure provides devices comprising a therapeutic agent bound to a printed three-dimensional structure. Ink formulations for three-dimensional printing are also disclosed. Additionally, provided herein are methods for manufacturing devices and uses thereof,
Resumen de: CN120093987A
本发明涉及一种表面修饰有序微纳米线的三维生物活性支架及其制备方法和应用，属于生物材料领域。所述三维生物活性支架包括生物活性支架基体和修饰在所述生物活性支架基体表面的拓扑结构层，其中，所述拓扑结构层由沿固定方向进行有序定向排布的微纳米线构成。本发明成功将有序微纳拓扑结构整合至三维组织工程支架中，可以对多种细胞进行有效的物理干预，同时也可以作为一种灵活的组织工程平台用于复杂组织的再生。另外，本发明将3D打印技术与表面刷涂技术相结合，构建表面具有有序微纳米线的生物活性支架，对组织工程支架的发展具有重要意义。
Resumen de: CN120093989A
本发明公开了一种光驱动/温度驱动双触发形状记忆抗菌抗肿瘤骨支架及其熔融沉积成型（FDM）制备方法，其特征在于：以聚乳酸（PLA）为基体，通过有机溶剂共混法将聚乙二醇（PEG）及纳米氢氧化镁（Mg(OH)2）/氧化铜（CuO）均匀分散，经干燥成膜‑粉碎造粒‑螺杆挤出工艺制备复合丝材，最终通过FDM工艺实现三维多孔支架一体化成型。所述支架通过PLA‑PEG的玻璃化转变调控与纳米金属氧化物颗粒光热效应协同，实现温度和近红外光双触发形状记忆。纳米Mg(OH)2/CuO赋予支架多模态抗菌抗肿瘤功能：1）Mg2+/Cu2+释放破坏微生物膜电位；2）近红外光热响应诱导细菌肿瘤细胞凋亡；3）Mg(OH)2降解形成碱性微环境调控抑制生物膜生成。该支架突破传统植入物形态固定局限，可通过光/热刺激触发形状自适应，精准贴合不规则骨缺损，避免二次手术风险，在微创骨科修复中具有显著优势。
Resumen de: CN120093608A
本申请涉及齿科修复用复合材料技术领域，尤其涉及一种高性能耐磨增强型牙科复合修复材料及其制备方法。一种高性能耐磨增强型牙科复合修复材料，包括以下制备原料：树脂45‑55份、改性耐磨填料30‑35份、改性玻璃纤维5‑8份、羟基磷酸钙6‑8份、抗菌剂0.5‑0.8份、偶联剂0.8‑1.2份、着色剂0.01‑0.02份、抗氧化剂0.1‑0.2份，其中，所述树脂，按质量份数计，包括以下制备原料：环氧树脂25‑35份、甲基丙烯酸类化合物60‑75份、固化剂1‑1.5份。本申请的高性能耐磨增强型牙科复合修复材料在力学性能、抗菌性能、生物相容性和应用范围等方面均表现出显著的优势，有望在牙科领域得到广泛应用。
Resumen de: CN120093463A
本发明涉及仿生牙技术领域，具体涉及一种基于复合陶瓷修复材料的3D打印梯度仿生牙体结构的方法，步骤S1,采用硅酸锂铝系生物陶瓷作为基础材料，经等离子体球磨处理得到均匀的粉末，将粉末与含3wt%光引发剂的聚乙二醇二丙烯酸酯树脂按42%‑46%粉水比配制浆料；步骤S2，将浆料进行真空脱泡机组三级处理；步骤S3，基于CT扫描数据，构建梯度应力分布模型，划分釉质层、牙本质层和牙髓腔过渡层；步骤S4，通过压电微滴喷射系统以50±5mm/s速度将浆料进行层积成型；步骤S5，将打印完成的仿生牙体结构采用梯度烧结工艺烧结成型。解决传统的修复材料往往难以精确模仿牙齿的这种梯度结构，导致修复体与周围组织之间的界面不稳定，容易出现炎症反应和排斥反应的问题。
Resumen de: FR3156030A1
Procédé de fabrication d’une prothèse dentaire partielle amovible, comportant des étapes de : a) fabrication d’au moins un bloc monolithique comportant une partie dent artificielle et une partie gencive artificielle, le bloc monolithique comportant au moins un premier organe d’assemblage, b) fabrication d’un châssis configuré pour supporter le bloc monolithique, le châssis comportant au moins un deuxième organe d’assemblage, puis c) assemblage du bloc monolithique avec le châssis par emboîtement du premier organe d’assemblage avec le deuxième organe d’assemblage formant la prothèse dentaire partielle amovible. Figure pour l’abrégé : Fig. 4B
Resumen de: US2025182869A1
A system for manufacturing an artificial covering includes a 3D surface scanning module and a 3D printing module where an anatomical surface is imaged and the image is processed for manufacturing and embedding a sensor or device in the covering which can be used for diagnosis or sensing medical issues in the user.
Resumen de: DE102023133592A1
Die Erfindung betrifft eine Schablone (2) für die Ausführung von Trennschnitten mittels eines scheibenförmigen Trennwerkzeugs in Knochen bei chirurgischen Eingriffen, insbesondere für Femur- und Tibia Resektion, mit einem Grundkörper (4) und einer darin ausgebildeten schlitzförmigen Öffnung (6) zum Durchgreifen mittels des scheibenförmigen Trennwerkzeugs, wobei die schlitzförmige Öffnung (6) das scheibenförmige Trennwerkzeug beim Durchgreifen der schlitzförmigen Öffnung (6) führt, indem die schlitzförmige Öffnung (6) von einander gegenüberliegenden und vorzugsweise zueinander parallelen Wandungsabschnitten (16, 18) begrenzt ist, wobei wenigstens einer der Wandungsabschnitte (16, 18) und vorzugsweise beide Wandungsabschnitte (16, 18) in die schlitzförmige Öffnung (6) einragende, mit dem Trennwerkzeug in gleitenden Kontakt bringbare und das Trennwerkzeug hierdurch führende Erhebungen (20, 24, 32, 38, 42) und gegenüber den Erhebungen (20, 24, 32, 38, 42) zurückgesetzte Vertiefungen (22, 26, 34, 40, 44) aufweisen, welche aufgrund ihrer Zurücksetzung keinen gleitenden Kontakt zu dem Trennwerkzeug ausbilden können.
Resumen de: AU2025203235A1
Abstract Threaded sacro-iliac joint stabilization (e.g., fusion, fixation) implants and methods of implantation and manufacture. Some implants include a threaded distal region, an optionally threaded central region, and an optionally threaded proximal region. The distal, central, and proximal regions have lengths such that when the implant is laterally implanted across a SI joint.The distal region can be positioned in a sacrum, the central region can he positioned across an SI-joint, and the proximal region can be positioned in an ilium. WO 2021/108590 PCT/US2020/062275 Nlhb Rtn Rt Ni
Resumen de: WO2025117593A1
A three-dimensional scaffold for use in engineered tissue includes a repeated 3D geometry; and at least one of a hydrogel, a biocompatible polymer, and a bioprintable polymer. The repeated 3D geometry may include an open geometry including a plurality of interconnected nodes configured to be seeded with living cells. The scaffold may be formed via bioprinting. The three-dimensional scaffold may also be used for (1) 3D tissue modelling (for liver, kidney, gut, pancreas, heart, lung, spleen, etc.), (2) disease modeling of different tumor types such as breast, colorectal, lung, liver, brain, ovarian and others, (3) drug testing / therapeutic screening of small molecule drugs, peptides, proteins, antibodies, ADCs, gene therapies, RNA-based therapeutics, cell therapies, and tissue therapies, and (4) therapeutic/drug delivery (i.e., via delivery device that can be used to control drug release based on different patterns).
Resumen de: WO2025116270A1
The present invention relates to: a photocurable restoration composition comprising a ceramic composition; and a dental prosthesis using a 3D printer. More specifically, the present invention relates to: a photocurable restoration composition comprising a silane-treated ceramic composition; and a dental prosthesis manufactured using the photocurable restoration composition by using a 3D printer. According to the present invention, it is possible to obtain a dental prosthesis having improved gloss, excellent thermal resistance and hardness, and improved uniformity and reliability.
Resumen de: WO2025114770A1
The present invention relates to an orally administered formulation comprising melatonin as an active ingredient and having a drug-release controlling property, and a method for preparing same by using 3D printing and relates to a pharmaceutical composition and a food composition, of the formulation, for preventing or treating jet lag, and a composition to be applied to a 3D printer.
Resumen de: JP2023165023A
To provide a kidney organoid and a manufacturing method thereof which can be used in various applications such as disease modeling, drug screening, regenerative medicine, and 5 scaling-up production of a kidney cell.SOLUTION: Provided is a kidney organoid including less than 50 nephrons.SELECTED DRAWING: None
Resumen de: WO2025117528A1
This disclosure provides polymerizable resin compositions comprising a hydrophobic polyether-containing polymerizable polyurethane compound to impart improved stain resistance to polymeric materials formed from the polymerizable resin compositions. Further provided herein are methods of producing the compositions and using the same for the fabrication of dental devices, such as orthodontic appliances.
Resumen de: WO2025117572A1
This disclosure provides laser markable polymerizable resin compositions comprising infrared absorbing marking additives to achieve improved laser markability of 3-D printed objects obtained from these polymerizable resin composition, and methods for marking the cured resin compositions using an infrared laser.
Resumen de: US2025177149A1
A system and computer-implemented method for manufacturing an orthopedic implant involves segmenting features in an image of anatomy. Anatomic elements can be isolated. Spatial relationships between the isolated anatomic elements can be manipulated. Negative space between anatomic elements is mapped before and/or after manipulating the spatial relationships. At least a portion of the negative space can be filled with a virtual implant. The virtual implant can be used to design and manufacture a physical implant.
Resumen de: US2025177145A1
A method of manufacturing a medical device made of polylactic acid (PLA) and hydroxyapatite (HA) aimed at the repair of fractures or considerable bone injuries, using 3D printing and electrospinning techniques.
Resumen de: US2025177151A1
A total knee replacement implant having an anatomically representative femoral component that is based on an average knee geometry model determined from scans of multiple people. The implant can be customized for a given patient by scaling the average knee geometry according to one or more measurements (e.g. AP and ML) of the patient's knee. The implant can be formed by 3D printing or any suitable fabrication technique.
Resumen de: US2025177011A1
Threaded sacro-iliac joint stabilization (e.g., fusion, fixation) implants and methods of implantation and manufacture. Some implants include a threaded distal region, an optionally threaded central region, and an optionally threaded proximal region. The distal, central, and proximal regions have lengths such that when the implant is laterally implanted across a SI joint, the distal region can be positioned in a sacrum, the central region can be positioned across an SI-joint, and the proximal region can be positioned in an ilium.
Nº publicación: US2025176824A1 05/06/2025
Solicitante:
WAVEFRONT DYNAMICS INC [US]
Wavefront Dynamics, Inc
Resumen de: US2025176824A1
This invention relates to optical methods and optical systems for making both on-axis and wide-field, peripheral off-axis wavefront measurements of an eye; and for designing and manufacturing wavefront-guided customized contact lens useful for myopia control. The wide-field optical instrument can comprise either (1) a multi-axis optical configuration using multiple off-axis beamlets, or (2) an instrument comprising a rotatable scanning mirror that generates off-axis probe beams.
BOPI
Sede Electrónica
