Alerta

FABRICATION OF ADDITIVELY MANUFACTURED OBJECTS WITH MECHANICALLY INTERLOCKING ELEMENTS

Resumen de: US20260048566A1

Materials and additively manufactured objects including mechanically interlocking elements are provided. In some embodiments, a method includes forming a dental appliance at least partially out of a composite material. The composite material can include an interlocking structure having a plurality of interlocking elements. The interlocking structure can have a first mechanical property. The composite material can also include a matrix surrounding at least a portion of the interlocking structure. The matrix can have a second mechanical property different from the first mechanical property.

MANDIBULAR RECONSTRUCTION SYSTEMS AND METHODS

Resumen de: US20260047933A1

Systems and methods for mandibular reconstruction are provided. An example system may comprise a drilling guide comprising: (1) a body configured to register against two adjacent surfaces of a native mandible when the body is temporarily secured to the native mandible; and (2) a tube extending from the body. The tube may be configured to constrain orientation of a drill bit when inserted through the tube and into the native mandible to reduce off-axis tilt of the drill bit when forming a void in the native mandible. Size and orientation of the void may correspond with size and orientation of a phalange of a neo-mandible assembly to be received within the void.

RUBBER KNEE REPLACEMENT APPARATUS AND METHOD FOR CUSTOMIZATION

Resumen de: US20260047936A1

A prosthetic knee replacement apparatus constructed of rubber avoids the disadvantages of metal prosthetics. The knee replacement apparatus includes a base member as a spacer between the upper and lower legs of a patient. A femoral portion extends upwardly from an upper surface of the base member and a tibial portion is coupled to a lower surface of the base member. The knee replacement apparatus may be constructed completely or substantially from a rubber material so as to reduce friction and degeneration. The knee replacement system may be constructed or even 3D printed after the leg bones of the patient are scanned.

VARIABLE THICKNESS DENTAL APPLIANCES AND ASSOCIATED METHODS

Resumen de: US20260047910A1

Dental appliances and associated methods are provided herein. In some embodiments, a dental appliance includes an appliance shell formed from a plurality of 3D printed polymer layers. The appliance shell can include a plurality of tooth receiving cavities arranged to receive a dentition and to exert one or more forces on the dentition, and a plurality of variable thickness regions integrally formed with the appliance shell as a single monolithic component. The plurality of variable thickness regions can include an upper thickened region at a first side of a tooth receiving cavity and a lower thickened region at a second side of the tooth receiving cavity opposite the first side. The upper and lower thickened regions can be configured to control movement of a tooth received within the tooth receiving cavity.

MICRONEEDLES AND METHODS OF MANUFACTURE THEREOF

Resumen de: EP4696508A2

A microneedle array (105) for administration of a substance of interest into a biological tissue is provided. The array comprises a base substrate (110) having a microneedle side (115) and an opposing back side (120); a primary funnel portion (925, 1125) extending from the microneedle side (115) of the base substrate; and two or more solid microneedles (130) extending from the at least one primary funnel portion. The solid microneedles (130) comprise a substance of interest. A microneedle patch (100) is also provided, which includes the microneedle array (105) as well as an adhesive layer (135) and a handle layer (140) affixed to the base substrate and comprises a tab portion (150). The tab portion extends away from the solid microneedles and permits a person to manually hold the tab portion to manipulate the patch without contacting the solid microneedles. Also provided is a method for making an array of microneedles.

PRINTHEAD AND SYSTEM FOR ELECTROPORATION, AND METHOD OF PRINTING PATTERNED TISSUE

Resumen de: WO2024228814A2

A method of printing patterned tissue includes flowing a bioink comprising cells and a biological cargo through a nozzle moving relative to a substrate and exposing selected voxels of the bioink to a pulsed electric field as the bioink flows through the nozzle. Consequently, a portion or all of the cells in each of the selected voxels undergoes electroporation and transfection with the biological cargo. A cell-laden filament comprising the bioink and including the selected voxels is continuously extruded from an outlet of the nozzle, and, as the nozzle moves relative to the substrate, the cell-laden filament is deposited in a predetermined pattern on the substrate. Thus, a tissue having spatial patterns of gene expression may be printed.

３Ｄプリンティング用細胞外マトリックスベースのハイブリッドインクおよびその製造方法

Resumen de: US2025058017A1

One embodiment of the present disclosure provides an extracellular matrix-based hybrid ink for 3D printing, the hybrid ink including an extracellular matrix having an amine group and a modified hyaluronic acid introduced with an ethylenically unsaturated bond functional group, in which the extracellular matrix and the modified hyaluronic acid are in a crosslinked state by a chemical bond formed between at least some of amine groups present in the extracellular matrix and the ethylenically unsaturated bond functional group present in the modified hyaluronic acid. According to an embodiment of the present disclosure, the hybrid ink has mechanical properties suitable for 3D printing through chemical crosslinking between the extracellular matrix and modified hyaluronic acid as constituents, and can control the drug release rate by adjusting the chemical crosslinking density.

FISH GELATINE BASED HYDROGEL FORMULATION

Resumen de: EP4696337A1

The invention relates to an aqueous composition comprising thiolated and norbornene-modified cold-water species-derived gelatine. A further aspect of the invention relates to a method to generate a three-dimensional hydrogel object, particularly an in vitro model for disease modelling/drug testing or an implant, comprising providing a composition according to the invention and forming the hydrogel object by bioprinting (extrusion-based or digital light-based (DLP)) or molding/casting to provide the three-dimensional hydrogel object.Also provided are a hydrogel implant obtained by a method according to the invention, and a kit comprising dried thiolated and norbornene-modified cold-water marine species gelatine.

SYSTEMS AND METHODS FOR DESIGNING OBJECTS

Resumen de: US2024342995A1

Systems and methods for designing additively manufactured objects are provided. In some embodiments, a method includes receiving a treatment plan for a patient's teeth, and determining a set of appliance parameters for a dental appliance configured to implement the treatment plan. The method can also include determining a set of manufacturing parameters for a fabrication system to be used to additively manufacture the dental appliance. The method can further include generating a 3D digital representation of an appliance geometry for the dental appliance. The appliance geometry can be configured to mitigate loss of fidelity at a target region of the dental appliance due to at least one manufacturing parameter of the fabrication system.

SUPPORT STRUCTURES FOR 3D PRINTED ORTHODONTIC DENTAL APPLIANCES AND MANUFACTURING METHODS THEREOF

Resumen de: US20260033918A1

The present disclosure provides a support of a 3D printed orthodontic dental appliance is provided. The orthodontic dental appliance includes a shell structure defined by an inner contour surface and an outer contour surface. The support comprises: a middle support including a middle support base mesh and a plurality of middle support struts and a main support configured to connect the middle support to a build platform of a 3D printing device used to print the orthodontic dental appliance. One end of each middle support strut of the plurality of middle support struts is connected to the orthodontic dental appliance at a junction of the inner contour surface and the outer contour surface, and the other end of the middle support strut is connected to a rim of the middle support base mesh.

一种生物仿生骨软骨生物电池及其制备方法和应用

Resumen de: CN121534223A

本发明提供了一种生物仿生骨软骨生物电池及其制备方法和应用，属于生物医用材料与组织工程技术领域。该生物电池包括阳极层、阴极层和隔膜层；所述阳极层由锌粉和水凝胶骨架组成，所述阴极层由二氧化锰粉和水凝胶骨架组成，所述隔膜层由聚偏氟乙烯粉和水凝胶骨架组成。本发明提供的生物电池能够模拟天然骨软骨组织电微环境与化学信号、具备仿生分层结构、并可实现程序化电刺激与离子释放。该电池不仅能提供稳定持久的内源性电刺激，还能引导内源性干细胞进行分区定向分化，从而实现骨软骨缺损的一体化、功能性再生。

为OSA症推荐治疗方案的系统、方法、设备及介质

Resumen de: CN121533835A

本发明提供了一种为OSA症推荐治疗方案的系统、方法、设备及介质，包括为初筛为OSA的患者进行口腔扫描，获取患者口腔数字印模；制取患者的牙齿印模；由所述口腔数字印模以及所述牙齿印模制作患者的预制口腔矫正器；采集患者在佩戴所述口腔矫正器时的第一睡眠监测数据，以及未佩戴所述口腔矫正器时的第二睡眠监测数据；对比所述第一睡眠监测数据以及所述第二睡眠监测数据，根据对比结果确定患者与口腔矫正器的适配性；根据患者与口腔矫正器的适配性为患者推荐合适的治疗方案。本发明能够解决OSA治疗成本高，治疗疗效不确切的技术问题。

TRANSALVEOLAR DENTAL IMPLANT AND METHOD OF MANUFACTURE

Resumen de: EP4659703A2

The present disclosure relates to single tooth or full arch dental restoration. In cases where patients have insufficient bone stock for conventional root-form dental implants, current solutions often fail to restore function. The present disclosure describes a transalveolar dental implant for single tooth or full arch dental restoration. The transalveolar dental implant is comprised of a post and a bone plate, the bone plate having a contoured portion fabricated to match the topography of a bony surface of the facial skeleton. Through primary fixation of the contoured portion of the bone plate, the transalveolar dental implant improves function and outcomes in affected patients.

多数の曲率を有するエラストマーシール形成構造

Resumen de: JP2025100573A

To provide a textile seal-forming structure with multiple curvatures.SOLUTION: A patient interface includes a seal-forming structure with a textile membrane which has at least one hole so that the flow of air at a therapeutic pressure is delivered to at least an entrance to the patient's nares and or the patient's mouth. The seal-forming structure is constructed and arranged to maintain the therapeutic pressure in a cavity of a plenum chamber throughout the patient's respiratory cycle in use. The textile membrane includes a first portion that is held in a relaxed state and a second portion that is held in a taut state. The taut state of the second portion is configured to allow the seal-forming structure to include a three-dimensional shape that has multiple curvatures.SELECTED DRAWING: Figure 12

Method for producing a multiphase polymer 3D gel dosimeter mimicking human tissues, soft, bone and lung, intended for radiotherapy treatment planning

Resumen de: PL449505A1

Przedmiotem zgłoszenia jest sposób wytwarzania wielofazowego polimerowego dozymetru żelowego 3D imitującego tkanki ludzkie, miękką, kostną i płucną, przeznaczonego do opracowania planu leczenia w radioterapii, z wykorzystaniem metody druku 3D polegającej na drukowaniu obiektu na podstawie jego modelu wirtualnego sporządzonego za pomocą programu komputerowego, poprzez wytwarzanie na podłożu bazowym za pomocą drukarki, której program sterujący jej pracą zawiera model wirtualny wytwarzanego obiektu, kolejnych warstw tego obiektu, jedna na drugiej z substratu do sporządzenia tego obiektu, aż do wytworzenia całego obiektu, który charakteryzuje się tym, że metodą druku 3D wytwarza się fazę dozymetru wielofazowego imitującą co najmniej jedną z tkanek tego wielofazowego dozymetru, na podstawie modelu wirtualnego drukowanej tkanki, który sporządza się na podstawie obrazów tkanki indywidualnego pacjenta, uzyskanych z tomografii komputerowej lub rezonansu magnetycznego, na podłożu bazowym ogrzanym do temperatury 50°C, z umieszczonego w dozowniku drukarki, zżelowanego roztworu dozymetrycznego do wytworzenia fazy wielofazowego polimerowego dozymetru 3D imitującej drukowaną tkankę. Roztwór dozymetryczny do wytworzenia fazy dozymetru wielofazowego imitującej tkankę kostną, roztwór dozymetryczny do wytworzenia fazy dozymetru wielofazowego imitującej tkankę miękką oraz roztwór dozymetryczny do wytworzenia fazy dozymetru wielofazowego imitują

一种硬组织修复材料及其制备方法

Resumen de: CN121513265A

本发明公开了一种硬组织修复材料及其制备方法。其中硬组织修复材料主要由无机钙盐和光固化高分子材料组成。特别涉及一种含寡聚磷酸钙（CPO）的聚乙二醇二丙烯酸酯（PEGDA）水凝胶材料及其制备方法。首次将CPO与PEGDA以一定比例复合，使用光引发剂（LAP或I2959），制备出机械强度较高、生物相容性优良的可注射水凝胶材料。利用模具法或三维（3D）打印技术进一步将水凝胶材料加工形成不同形状的立体结构，用于临床硬组织（如骨组织、牙组织）缺损修复。该材料具有适应性强、安全系数高、使用方便快捷、应用前景广阔等特点。

一种肩关节抗生素间隔器的制备方法

Resumen de: CN121515462A

本发明涉及医学辅助工具的制备方法，尤其涉及一种肩关节抗生素间隔器的制备方法。它包括以下步骤，A、将健侧的CT扫描数据输入3D软件得健侧的肱骨全长3D模型，健侧模通过镜像制作“患侧”正常肱骨全长3D模型得纠正模；B、通过纠正模数据确认肩关节抗生素间隔器模型：C、制作肩关节抗生素间隔器模具并通过3D打印机打印出肩关节抗生素间隔器模具；D、在肩关节抗生素间隔器模具的上模腔和下模腔中填充满骨水泥后合膜直至骨水泥完全固化，得肩关节抗生素间隔器。本发明所得肩关节抗生素间隔器更加美观和精准，从而更好维持软组织张力、适应上臂长度，它与感染切除后缺损骨结构匹配和接触，为间隔期肱骨截骨后需修复结构提供更好稳定性。

用于微导管塑形的方法及相关产品

Resumen de: CN121515465A

本申请公开了一种用于微导管塑形的方法及相关产品，其中所述方法包括：控制塑形指对塑形丝实施塑形，以将所述塑形丝塑造成目标形状；在塑形过程中，对所述塑形嘴、所述塑形指以及所述塑形丝之间进行碰撞检测；根据碰撞检测结果确定相应的碰撞处理操作。通过本申请方法能够及时检测出碰撞并处理，进而避免造成不可逆的塑形错误。

一种光固化生物墨水及其制备方法和应用

Resumen de: CN121513271A

本发明涉及一种光固化生物墨水及其制备方法和应用，属于生物材料及组织工程技术领域。该光固化生物墨水包括甲基丙烯酰化鱼鳞明胶和光引发剂，其中，甲基丙烯酰化鱼鳞明胶由鱼鳞明胶与甲基丙烯酸酐通过酰化反应制得，甲基丙烯酰化鱼鳞明胶的取代度为30%~55%。该光固化生物墨水兼具快速光固化、低免疫原性、低脂肪含量及优良生物相容性，特别适用于软骨、皮肤、血管等精细组织工程支架和类器官的3D生物打印构建。

负载生长因子的双层GelMA-AlgMA功能性水凝胶支架的制备及其应用

Resumen de: CN121513272A

本发明公开了负载生长因子的双层GelMA‑AlgMA功能性水凝胶支架的制备及其应用。包括以下步骤：制备复合KGN的GelMA水凝胶前体溶液；制备复合 BMP‑2的AlgMA水凝胶前体溶液；3D打印。本发明的有益效果在于：将复合KGN的GelMA和复合 BMP‑2的AlgMA结合为双层支架，KGN促进软骨形成，BMP‑2促进骨形成，生长因子针对性地释放，针对骨软骨界面的不同组织层进行特异性修复。

A METHOD OF DESIGNING AN ORTHODONTIC APPLIANCE FOR MOVING ONE OR MORE TEETH OF A PLURALITY OF TEETH, AND SYSTEM TO GENERATE A PLURALITY OF SUCH APPLIANCES.

Resumen de: US2025152310A1

A dental appliance may include a first plurality of tooth receiving cavities for anterior teeth and a first plurality of attachment receiving cavities shaped to impart a first plurality of forces and a first counter moment to the anterior teeth, the first plurality of forces being to direct at least one tooth in a posterior direction. The dental appliance may include a second plurality of tooth receiving cavities for posterior teeth and a second plurality of attachment receiving cavities to impart a second plurality of forces and a second counter moment the posterior teeth, the second counter moment being in a direction opposing the first counter moment. At least a portion of the second plurality of forces may be configured to oppose the first plurality of forces. The first counter moment and the second counter moment may be configured to be coupled to form a differential moment.

THREE-DIMENSIONAL IMPLANT WITH HYDROPHILIC SURFACE

Resumen de: AU2024289833A1

The disclosure provides a 3D tissue reconstruction implant having a hydrophilic implant surface and consisting of a bio-resorbable material, wherein the implant surface is considered hydrophilic when assessed using an ink test following ISO 8296:2003 and adapted to a 3D surface, wherein said ink test comprises incubating the implant for 1 min in a solution consisting of an ink with a surface tension of 72 mN/m and water and wherein after incubation of the implant in said solution an ink colored implant surface is indicative for a hydrophilic implant surface. The disclosure also provides said implant for use in tissue reconstruction, (soft) tissue support, tissue augmentation and/or implant revision and the use of said implant for reconstructing, augmenting and/or revising a tissue and/or supporting a (soft) tissue, respectively, wherein the implant is inserted into a patient. Further the disclosure provides a method of manufacturing a tissue reconstruction implant with a hydrophilic implant surface.

DENTAL RESTORATION MOLDS

Resumen de: US20260041530A1

A custom tool for forming a dental restoration in a patient's mouth includes a facial mold body and a lingual mold body, each configured for a patient-specific, customized fit with respective sides of at least one tooth. The facial and lingual mold bodies each include restorative portions and engagement portions that interlock at locations offset from a mold cavity formed between the restorative portions. The engagement portions are dimensioned to produce a residual seating pressure that maintains the mold bodies in a clamped state when interlocked, facilitating accurate shaping of restoration material within the mold cavity. The tool may include apertures for injection of restorative material, hinged doors or plugs for sealing, and vents for controlling material flow. The device and associated methods enable the digital design and fabrication of custom dental restoration molds for single or multiple teeth, improving restoration quality and reducing overall clinical or procedural complexity.

ORTHODONTIC BRACKET AND BRACKET SUPPORT SYSTEM AND METHOD

Resumen de: US20260041526A1

An orthodontic bracket and bracket support system, and its method of manufacture and use is provided. The system includes a bracket assembly including one or more bracket members to be bonded to a patient's teeth, a placement guide assembly including one or more placement members to properly position the bracket members for the bonding procedure, and a support assembly to support the bracket assembly and/or the placement guide assembly during manufacture and use. The bracket assembly, the placement guide assembly, and the support assembly are formed together and in combination using stereolithography three-dimensional (3D) printing.

SHAPE MEMORY POLYMER-BASED DEVICES AND METHODS OF USE IN TREATING INTRACORPOREAL DEFECTS

Nº publicación: US20260041435A1 12/02/2026

Solicitante:

THE BOARD OF REGENTS OF THE UNIV OF OKLAHOMA [US]
The Board of Regents of the University of Oklahoma

Resumen de: US20260041435A1

A novel shape memory polymer (SMP)-based device for surgical treatment of an intracorporeal defect (e.g., a void or anomaly) such as an intracranial aneurysm or fistula. In at least one non-limiting embodiment, the SMP device is a 3D-printed SMP material sized to specifically fit and thus occlude an intracranial aneurysm (ICA). The SMP device may be delivered to the intracorporeal defect via a catheter having a heating mechanism wherein the SMP device is raised above its glass transition temperature as it is deployed, causing the SMP device to return to its permanent shape after it is deployed into the intracorporeal defect. SMP device delivery systems that include the SMP devices, as well as methods of making and using the devices and systems, are also disclosed.