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METHOD, SYSTEM AND COMPUTER PROGRAM PRODUCT FOR CGM-BASED PREVENTION OF HYPOGLYCEMIA VIA HYPOGLYCEMIA RISK ASSESSMENT AND SMOOTH REDUCTION INSULIN DELIVERY

Resumen de: EP4814986A2

0001 An aspect of an embodiment or partial embodiment of the present invention (or combinations of various embodiments in whole or in part of the present invention) comprises, but not limited thereto, a method and system (and related computer program product) for continually assessing the risk of hypoglycemia for a patient and then determining what action to take based on that risk assessment. A further embodiment results in two outputs: (1) an attenuation factor to be applied to the insulin rate command sent to the pump (either via conventional therapy or via open or closed loop control) and/or (2) a red/yellow/green light hypoglycemia alarm providing to the patient an indication of the risk of hypoglycemia. The two outputs of the CPHS can be used in combination or individually.

SYSTEM FOR MUSCLE STIMULATION AND/OR IMPEDANCE MEASUREMENT TO VERIFY PROPER TUBE PLACEMENT

Resumen de: EP4814981A2

0001 A system comprises a tubing assembly including a catheter extending in a longitudinal direction between a proximal end and a distal end and defining a lumen therebetween. The system further comprises a stimulation electrode assembly for delivering an electrical stimulation waveform to tissue at a voltage of 1.01 V to 100 V, a recording electrode assembly, and a processor. In operation, the stimulation electrode assembly generates and delivers the electrical stimulation waveform to the tissue. The recording electrode assembly monitors, over a frequency range, electrical activity elicited by the tissue in response to a noise signal and communicates the monitored electrical activity to the processor in real time. The system thus enables tissue stimulation and real-time monitoring of the resulting electrical activity.

INDICATOR AND ANALYTICS FOR SENSOR INSERTION IN A CONTINUOUS ANALYTE MONITORING SYSTEM AND RELATED METHODS

Resumen de: EP4814988A2

The present embodiments provide systems and methods for, among others, tracking sensor insertion locations in a continuous analyte monitoring system. Data gathered from sensor sessions can be used in different ways, such as providing a user with a suggested rotation of insertion locations, correlating data from a given sensor session with sensor accuracy and/or sensor session length, and providing a user with a suggested next insertion location based upon past sensor accuracy and/or sensor session length at that location.

DOWNLOADING AND BOOTING SYSTEM FOR A WEARABLE MEDICAL DEVICE

Resumen de: EP4814978A2

0001 A wearable medical monitoring device can include a monitor and an update manager. The monitor is configured to monitor a physiological parameter of a subject. The update manager is configured to receive a software update corresponding to the at least one software module for the monitor, and cause an installation of the software update such that the at least one software module installed on the monitor is updated. A wearable medical monitoring device can also include at least one processor, and a supervisory circuit configured to provide redundant booting. The supervisory circuit is configured to monitor a state of the processor when the processor is configured to boot from a current drive. The supervisory circuit is further configured to control the processor to boot from an alternative drive based on the state of the at least one processor or if there is an error caused by the current drive.

SYSTEMS AND METHODS FOR COORDINATING MANUFACTURING OF CELLS FOR PATIENT-SPECIFIC IMMUNOTHERAPY

Resumen de: EP4814976A2

0001 Methods and systems are disclosed herein. A method of manufacturing a cell therapy product for treating cancer in a patient comprises initiating manufacturing of the cell therapy product from at least a portion of a tumor or a population of cells obtained from the patient using a multi-step cell expansion process, based on a cell order request to manufacture the cell therapy product, a preliminary schedule of patient treatment events for treating the patient with the cell therapy product, and a selected manufacturing slot at a manufacturing facility, wherein the manufacturing slot is selected from a plurality of available manufacturing slots based on the preliminary schedule of patient treatment events; performing quality control assays to determine acceptance parameters at each of a plurality of time points during the multi-step cell expansion process, wherein the acceptance parameters comprise one or more of viability, sterility, cell count, mycoplasma count, CD3 count, a result of an endotoxin assay, and a result of a Gram strain assay; determining, during the manufacturing of the cell therapy product, whether the acceptance parameters determined at respective time points meet acceptance criteria associated with the respective time points; in response to a determination that the acceptance parameters at a first time point of the plurality of time points meet the acceptance criteria, continuing the multi-step cell expansion process, or in response to a determination

Techniques for generating superresolution presentations of medical procedure video data

Resumen de: US12745894B1

0000 In some embodiments, a method of automatically generating high-resolution images of features of interest to accompany video data of a medical procedure of a given type is provided. A computing system provides the video data of the medical procedure to a first machine learning model trained to annotate features of interest. The computing system provides annotated portions of the video data to a second machine learning model trained on past images of features of interest to produce superresolution images of features of interest. The computing system generates a presentation of the video data of the medical procedure that includes the superresolution images of the features of interest produced by the second machine learning model.

一种光固化3D打印聚丙交酯-己内酯树脂复合材料的制备方法

Resumen de: CN122832214A

本发明公开了一种光固化3D打印聚丙交酯‑己内酯树脂复合材料的制备方法。将L‑丙交酯与ε‑己内酯按质量比为1:9‑9:1混合。本发明通过严格控制开环聚合及封端反应的工艺参数，确保了PLCL‑D预聚物分子量分布窄、端羟基含量高，且甲基丙烯酸酯封端率高，结合特定的后处理工艺，去除了未反应的甲基丙烯酸酐及溶剂，显著降低了细胞毒性；采用“纳米羟基磷灰石+球磨珍珠粉+MPC”的三元复合体系，纳米HA提供骨传导性，微米级珍珠粉起到微增强及促进骨生长作用，2‑甲基丙烯酰氧乙基磷酸胆碱的引入赋予材料优异的抗蛋白吸附性和血液相容性，三者协同作用，解决了单一填料分散难、力学弱的问题，显著提高了生物相容性和力学强度。

一种在多孔钛合金全域均匀制备载药生物活性涂层的方法

Resumen de: CN122833589A

本发明公开了一种在多孔钛合金全域均匀制备载药生物活性涂层的方法，属于生物医用材料技术领域，包括如下步骤：（1）基材预处理；（2）物理复合预处理；（3）化学浸渍处理；（4）功能性药物负载；（5）封孔处理。本发明整体工艺配合合理，整体相对简单，提供的物理预处理+化学复合沉积协同工艺，稳定的在多孔钛合金内外孔隙全域构建了均匀、高结合力、可控缓释的载药生物活性涂层，同时兼具抑菌、促成骨双重功能，极具推广应用价值和市场竞争力。

一种抗电化学腐蚀的间隙氧金属材料及制备方法和应用

Resumen de: CN122833409A

本发明涉及金属植入物材料技术领域，具体涉及一种抗电化学腐蚀的间隙氧金属材料及制备方法和应用。本发明将金属基材置于含氧混合气流中，在氧分压为100Pa～200Pa，温度为500℃～1000℃下进行热处理，使间隙氧原子通过晶格间隙扩散并原位固溶于金属基材表层，形成间隙氧梯度过渡层，随炉冷却，得到梯度间隙氧金属材料；所述金属基材的材料为钽或其合金。本发明通过采用间隙氧原子引入方式，调控氧分压和热处理条件，使间隙氧原子通过晶格间隙扩散并原位固溶于金属基材表层，形成间隙氧梯度过渡层，避免传统工艺所形成的较厚氧化层的形成，从根本上解决了覆层剥离问题，也避免了涂层剥落产生的磨屑颗粒诱发炎症的风险。

使用可变温度控制的树脂的增材制造

Resumen de: EP4005777A1

0001 Provided herein are systems and processes to control multiple temperatures in additive manufacturing. Such temperature control adjusts polymer properties and facilitates processing of materials to form 3D objects. The systems and processed disclosed herein also facilitate the processing of typically difficult-to-process materials and deliver such materials to a photocuring zone configured to photopolymerize materials into 3 dimensional objects with a layer-by-layer process. Such processes can include the steps of heating a resin to a flowable temperature, applying the resin to a carrier, cooling the film to increase viscosity or to solidify the resin, and applying the film containing the resin onto an area being printed, then photocuring the film. Also provided herein are resins and related polymer materials having properties that are tunable with exposure to more than one temperature zone. The formed polymers can include multiple regions of polymer material, each independently having distinct properties. Processes and systems are also provided herein that are configured to produce polymeric materials having multiple regions with distinct properties from a single-component formulation.

矩阵式多通道电极笔的保护笔帽

Resumen de: CN122827690A

本发明公开了一种矩阵式多通道电极笔的保护笔帽，包括套筒、末端盖和连接件。套筒用于紧密贴合地套设在矩阵式多通道电极笔的主体前部上并使主体前部的末端伸出；末端盖用于适配地套盖在主体前部的末端并与套筒对接；连接件连接于套筒和末端盖且允许末端盖套盖在主体前部的末端以及从主体前部的末端取下。本发明能够有效保护矩阵式多通道电极笔，延长矩阵式多通道电极笔使用寿命，提高实验检测数据的精确度，并且不影响保护矩阵式多通道电极笔正常操作，同时，使用便捷，具有较好的经济性。

一种可降解乳房支架制造方法及可降解乳房支架

Resumen de: CN122827821A

本申请涉及医疗器械技术领域，具体涉及一种可降解乳房支架制造方法及可降解乳房支架。可降解乳房支架制造方法包括：获取患者健侧乳房的灌注参数图谱；基于健侧乳房的灌注参数图谱生成重建侧乳房的目标灌注参数图谱；基于目标灌注参数图谱获得重建侧乳房区域的组织生长速率综合指数；根据组织生长速率综合指数生成打印参数；依据打印参数通过增材制造成型得到可降解乳房支架。上述方法以健侧灌注参数为基础生成重建侧目标灌注参数，进而获得组织生长速率综合指数以生成打印参数，使打印出的支架孔隙结构与预期组织生长速率相匹配，从而获得较好的乳房重建效果。

Movement disorder therapy system, devices and methods of remotely tuning

Resumen de: US12746393B1

0000 The present invention relates to methods for remotely tuning treatment parameters in movement disorder therapy systems where the subject and clinician are located remotely from each other. The present invention still further provides methods of quantifying movement disorders for the treatment of patients who exhibit symptoms of such movement disorders including, but not limited to, Parkinson's disease and Parkinsonism, Dystonia, Chorea, and Huntington's disease, Ataxia, Tremor and Essential Tremor, Tourette syndrome, stroke, and the like. The present invention yet further relates to methods of remotely tuning a therapy device using objective quantified movement disorder symptom data to determine the therapy setting or parameters to be transmitted and provided to the subject via his or her therapy device. The present invention also provides treatment and tuning remotely, allowing for home monitoring of subjects.

3D打印用双固化互穿网络树脂、3D打印义齿基托及其制备方法

Resumen de: CN122832207A

本申请涉及一种3D打印用双固化互穿网络树脂、3D打印义齿基托及其制备方法，通过自由基可聚合组分、阳离子可聚合组分、反应型相容组分、自由基光引发剂和阳离子光引发剂的协同设计与组分选择，搭配先光固化后热固化处理的双固化技术，构建了以双交联网络互相贯穿为主、缠结并伴随界面化学连接稳定双互穿网络结构，使得原料中丙烯酸双键转化率高达85%以上，同时环氧基团转化率高达80%以上，凝胶分数高达93%以上，进而获得了具有优异力学性能且更适合口腔湿热环境长期使用的3D打印义齿基托，对于推动光固化3D打印义齿基托的临床应用极具重要意义。

Internally Coloured Nano Ceramic Ink for High-Performance Dental Inkjet 3D Printing and Preparation Method Thereof

Resumen de: LU605609B1

The application relates to an internally coloured nano ceramic ink for high- performance dental inkjet 3D printing and a preparation method thereof. The ink of the application has simple components, realizes stable and uniform colouration by adding organometallic salt, and simultaneously introduces an alumina stabilizer and silicate glass powder, so that the dental zirconia ceramic prepared by inkjet 3D printing has an aesthetic effect on the basis of improving the mechanical properties and thermal expansion matching of the ceramic.

MEW TISSUE SCAFFOLD

Resumen de: US2022257371A1

0001 The disclosure relates to a melt electrowritten soft tissue scaffold and methods of making the same. The scaffold has a body having a first region comprising a first set of fibres and a second set of fibres, the first region being anisotropic. The first set of fibres are arranged approximately parallel relative to one another, each fibre of the first set of fibres has a serpentine arrangement forming peaks and troughs, the first set of fibres has a first Young's modulus. The second set of fibres are arranged approximately parallel relative to one another, the second set of fibres being arranged transversely relative to the first set of fibres, each fibre of the second set of fibres has a serpentine arrangement forming peaks and troughs, the second set of fibres has a second Young's modulus. The first Young's modulus is unequal to the second Young's modulus. In some embodiments the body further comprises a second region extending from the first region. The second region supports the first region.

一种基于3D打印技术的原位矿化胶原支架材料及其制备方法

Resumen de: CN122805893A

本申请公开了一种基于3D打印技术的原位矿化胶原支架材料及其制备方法，包括如下步骤：S1：使用有机溶剂溶解胶原，配置成预设浓度的胶原溶液；S2：使用纯化水分别配置预设浓度的钙离子溶液与磷酸根离子溶液；S3：在胶原溶液中分别加入钙离子溶液与磷酸根离子溶液，配置为两种含有不同矿物离子的原位矿化3D打印墨水；S4：装入到不同打印料筒中进行打印，打印结束后将支架置于干燥皿中干燥预设时间；S5：配置预设浓度的交联溶液，将支架浸泡，得到的支架用纯化水洗涤，干燥得到原位矿化胶原支架材料。属于骨植入物技术领域，该结构能够解决现有可降解人工骨材料一般强度较低且没有合适的孔径及孔隙率满足骨细胞爬行替代的问题。

一种促成骨分化的3D打印钛合金仿生多孔人工骨及其制备方法和应用

Resumen de: CN122805879A

本发明公开了一种促成骨分化的3D打印钛合金多孔仿生人工骨、制备方法及应用，属于生物医用材料领域。该人工骨由钛金属骨架构成，内部具有相互连通的多孔网状结构；多孔网状结构模仿人体第四腰椎松质骨的三维微观结构设计而来，其平均孔径为60.3‑73.9μm，孔隙率为67.9%‑80.5%。制备方法为获取骨密度恢复较快的第四腰椎断层图像，提取松质骨结构进行三维重建，经选区激光熔化技术打印成型。本发明的特定物理拓扑结构能有效激活骨髓间充质干细胞的Notch2信号通路，诱导成骨分化。应用于临界骨缺损修复时，可增加缺损部位的新骨生成量，提升愈合区域的弹性模量与最大弯曲应力，实现良好的骨整合。

一种个性化耳廓再造3D生物打印复合墨水

Resumen de: CN122805891A

本发明涉及组织工程及3D生物打印技术领域，具体涉及一种个性化耳廓再造3D生物打印复合墨水。所述复合墨水包括明胶甲基丙烯酰水凝胶基质、脱细胞软骨基质微碎片、仿生增强相、天然可见光交联体系、动态共价交联组分、患者自体耳廓软骨细胞与脂肪来源间充质干细胞，以及负载转化生长因子‑β3的缓释微球。该复合墨水在喷嘴剪切作用下发生剪切变稀，沉积后经405nm可见光交联形成具有弹性、自修复性及可控降解性的耳廓支架，并通过仿生微通道改善内部营养输送。该复合墨水能够适配患者健侧耳廓扫描数据生成的个性化模型，提高复杂耳廓结构的打印精度、细胞存活率和长期形态稳定性，促进软骨基质沉积及新生软骨形成。

医疗设备及诊疗系统

Resumen de: CN224796628U

本实用新型公开一种医疗设备及诊疗系统，医疗设备包括设备主体、辅助器件和驱动组件，设备主体的内部形成有安置腔，安置腔具有开口；辅助器件收容在安置腔内，且可沿预设方向经开口向外移出，辅助器件包括打印机；驱动组件设于设备主体，且与辅助器件驱动连接；其中，在确认打印机完成打印后，驱动组件驱动打印机经开口向外移出。本实用新型采用相对简单的结构，实现辅助器件在稳定收纳和精准推送之间的自动切换，有助于提升辅助器件和医疗设备之间的使用品质和使用可靠性。

一种基于骨粘合剂的3D打印骨修复体及其制备方法

Resumen de: CN122805882A

本发明公开了一种基于骨粘合剂的3D打印骨修复体及其制备方法，属于医用修复材料制备技术领域。所述骨修复体包括可吸收聚合物支撑网及填充于其内部的骨粘合剂，所述骨粘合剂的液相固化液为柠檬酸与丙二酸的混合酸水溶液。本发明还公开了所述骨修复体的制备方法，通过双喷头3D打印技术分别构建支撑网和填充骨粘合剂，并根据修复体尺寸自适应选择是否打印支撑网。本发明利用柠檬酸与丙二酸的协同效应显著提升了骨粘合剂的抗压强度、降解pH稳定性和降解速率适配性，实现了与骨再生周期的精准匹配，可广泛应用于颅骨、颌面、牙槽骨及四肢骨等不同类型骨缺损的个性化修复。

一种光固化PEGDA材料的合成方法及其SLA 3D打印应用

Resumen de: CN122810377A

本发明涉及一种光固化PEGDA材料的合成方法及其SLA 3D打印应用，包括以下步骤：合成PEG和甘油的摩尔比呈预设比值的PEGD线性聚合物，所述预设比值的取值范围为20:80～60:40；对所述PEGD线性聚合物进行纯化；对纯化后的PEGD线性聚合物的末端丙烯酸酯化，以获得能够应用于SLA 3D打印的PEGDA材料，具有使制成的PEGDA材料具备光固化性能、状记忆效应、生物降解性和机械强度，适用于高分辨率的SLA打印的优点。

人工知能基盤のロボット支援整形外科的運動システム及び方法

Resumen de: WO2025211918A1

Disclosed is an exercise system including: a walking exercise device including an effector having at least one link that drives a pedal on which a patient stands; and a system operation device for controlling a main effector according to a training plan for each individual to conduct walking training for the patient, wherein the system operation device includes: an index prediction unit having an index prediction model for predicting a walk evaluation index of the patient on the basis of basic information including personal information and initial walking state information of the patient; a training planning unit for establishing an individual training plan for each patient on the basis of the predicted waling evaluation index; a training evaluation unit for evaluating a training result on the basis of training result data according to a result of rehabilitation training of the patient performed by the walking exercise unit; and a reporting unit for performing reporting on the training result on the basis of the evaluation of the training result.

医療システム

Resumen de: US20240306891A1

0000 A system can automatically regulate irrigation, suction, or both, such as during a lithotripsy procedure. The system can include one or more sensors. Processing circuitry can be configured to generate an indication of a level of turbidity of a solution at or near a distal tip of a flexible scope, such as based on one or more signals from the one or more sensors. A control signal can be used to adjust an irrigation flow rate and/or a suction rate at the distal tip of the flexible scope. The level of turbidity can be determined using a sensor to measure electrolytic conductivity of the solution, a sensor to measure electromagnetic induction across a coil at the distal tip of the flexible scope and/or a measure of back reflected light or a measure of absorbed light emitted into the solution by a light source and measured by a light sensor.

パーキンソン病の事例の分類

Nº publicación: JP2026532104A 25/09/2026

Solicitante:

クアンタルエックスニューロサイエンスリミテッド

Resumen de: WO2025057081A1

A system (28) includes multiple electrodes (22) configured to record respective signals produced, by a brain of a patient (12) suffering from a particular subtype of Parkinson's Disease (PD), in response to magnetic stimulation of the brain. The system further includes a processor (32) configured to receive the signals, to identify a subset, of multiple subtypes of PD, to which the particular subtype belongs, by processing the signals, and to output an output indicating the subset of the subtypes. Other embodiments are also described.