Alerta

DRY POWDER FORMULATIONS OF EPINEPHRINE AND ASSOCIATED METHODS

Resumen de: US20260294804A1

0000 Provided herein are dry powder formulations comprising epinephrine alone or in combination with at least one enabling agent suitable for nasal application. Also provided are unit dose forms and devices comprising such formulations and methods of using such formulations for the treatment of various conditions including anaphylaxis, anaphylactoid reaction, respiratory conditions, hemodynamic collapse, and for administration during cardiopulmonary arrest and other life-threatening conditions.

MEDICATION FLUID DELIVERY DEVICE

Resumen de: US20260295152A1

A medication fluid delivery device and methods are provided with the delivery device having a dispensing unit and a drive unit that are attachable together. The dispensing unit includes a dispenser for delivering medication fluid to a user and a reservoir configured to be filled with a variable amount of medication fluid received from a medication fluid injector. The drive unit includes a control unit that controls the drive unit and causes medication fluid in the reservoir to be pumped through the dispenser and includes a registration mechanism configured to act with the dispensing unit to determine a state the reservoir including an initial level of the filled reservoir.

MEDICAL TEST STRIP ANALYSIS

Resumen de: US20260298952A1

0000 A system having a processor and memory coupled to the processor is provided. The memory stores a local testing database having a test configuration profile with the test configuration profile having an intensity threshold value denoting a positive test result. The system includes a carrier for receiving a cassette containing a lateral flow assay (“LFA”) strip and an LFA strip reader coupled to the processor for reading the LFA strip regardless of alignment of the cassette within the carrier and for transmitting an LFA strip image to the processor. The processor determines an LFA test result based on comparing an intensity value of a portion of the LFA strip image to the intensity threshold value and provides the LFA test result on an indication panel.

CLOSED-LOOP SLEEP MANAGEMENT METHOD, HEAD-WORN CLOSED-LOOP SLEEP MANAGEMENT SYSTEM, AND ELECTRONIC DEVICE

Resumen de: US20260295203A1

0000 A closed-loop sleep management method applied to a head-worn closed-loop sleep management device includes: performing sleep monitoring in real time based on an electroencephalogram (EEG) signal, an electrooculogram (EOG) signal, a heart rate (HR), and a blood oxygen saturation (SpO<2>); and controlling an intervention component to perform sleep intervention when a sleep monitoring result meets a preset condition. The sleep monitoring includes sleep staging and calculation of a duration of a current sleep stage. The sleep monitoring result includes the current sleep stage and the duration thereof. The method applies a deep learning algorithm to perform sleep staging and calculate the duration of the current sleep stage based on multi-modal signals, enabling real-time and accurate sleep state monitoring. Additionally, the method can achieve effective dynamic sleep intervention based on the sleep monitoring result, achieving closed-loop management from sleep monitoring to sleep intervention.

TOILET BIOMETRIC DATA COLLECTION DEVICE

Resumen de: US20260303938A1

0000 A biometric data collection device for a toilet includes a first compartment, a second compartment, and a bridge. The first compartment includes a first circuit board. The second compartment includes a second circuit board. The bridge is coupled to the first compartment and the second compartment and is configured to be supported by a rim of the toilet so that the first compartment is inside of a bowl of the toilet and the second compartment is outside of the bowl of the toilet. The bridge is changeable in length to fit different widths of the rim.

METHOD FOR MANUFACTURING ORTHODONTIC DEVICE BY USING INSERTION PATH

Resumen de: US20260294588A1

The present invention relates to a program for designing an orthodontic appliance. The method comprises: displaying, on a screen, the insertion path for determining the insertion direction of the appliance (S01); designating a tooth targeted for the insertion path setting (S02); setting the insertion path for the designated tooth in an arbitrary direction (S03) ; displaying, on the screen, undercuts of each tooth caused by the set insertion path (S04) ; calculating and storing depth values of the undercuts for each tooth (S05); and calculating and storing the total sum of undercut volumes for each tooth according to the insertion path (S06).

GENERATING FUNCTIONAL BRAIN MAPPINGS AND ACCOMPANYING REFERENCE INFORMATION

Resumen de: US20260294324A1

0000 A method for mapping functionally related brain regions of a subject. The method includes receiving a structural brain image and a dataset of resting-state functional MRI (rs-fMRI) three-dimensional (3D) image frames of a brain of the subject includes 3D image frames of the subject's brain over time. A functional connectivity map identifying groupings of functionally connected voxels is overlaid on the structural brain image. Spontaneous brain activations associated with each voxel in a grouping of functionally connected voxels are time-correlated with spontaneous brain activations in one or more other voxels in the grouping of functionally connected voxels. A reference location map for a pre-defined resting state network is generated, including reference information output. The reference location map includes brain reference locations that are informative of the one or more resting-state networks to assist a user in identifying the resting state network of the functional connectivity map.

PATIENT INTERFACE AND CUSHION THEREOF

Resumen de: US20260295189A1

A patient interface comprising a plenum chamber, a seal-forming structure constructed and arranged to form a seal with a region of the patient's face surrounding an entrance to the patient's airways, and a vent to allow a continuous flow of gases exhaled by the patient from an interior of the plenum chamber to ambient. The seal-forming structure may comprise a cushion, the cushion being deformable and resilient and at least partially formed by a lattice structure.

APPARATUS FOR THREE-DIMENSIONAL SENSING

Resumen de: US20260298906A1

An apparatus for three-dimensional sensing is disclosed. The apparatus comprises an electrode housing, comprising: two or more walls capable of encompassing a 3D model, wherein at least two walls are detachably connected to each other, forming at a connected state an angle greater than 0 degrees, between surfaces of each of the two or more walls; and wherein each wall comprises an electrode array, extending out from the wall towards the 3D model, configured to sense electrical activity of the 3D model.

LOCAL MANUFACTURING OF A MEDICAL STENT BASED ON A COMPUTATIONAL MODELED OUTCOME PREDICTION

Resumen de: US20260294653A1

A method for additive manufacturing of a medical stent includes generating, by a processor (152) executing instructions, a model of anatomy of a subject; obtaining a computer (140)-aided design (CAD) model of a stent; simulating deployment of the stent in the anatomy of the subject; determining whether the model of the stent satisfies an optimization metric based on the simulating, and optimizing the model of the stent by repeating obtaining and the simulating until the model of the stent satisfies the optimization metric. The stent is manufactured by additive manufacturing in response to the model of the stent being optimized.

PHOTOCROSSLINKABLE RECOMBINANT BACTERIAL COLLAGEN-LIKE PROTEINS

Resumen de: US20260297142A1

0000 Recombinant bacterial collagen-like protein with an amino acid sequence that is at least ≥60% identical to the amino acid sequence of SEQ ID NO:1 characterized in that the amino acid sequence comprises a deletion of at least 38 amino acids at the N-terminus of the amino acid sequence of SEQ ID NO:1 and that the recombinant collagen-like protein is functionalized with ethylenic unsaturated groups.

Health Safety and Status System, Service, and Platform, and Corresponding Methods

Resumen de: US20260301894A1

0000 A computer-implemented method includes accessing, by a processor of health safety credential platform, an access requirement associated with a venue or service; accessing, a certified health status record associated with an individual; comparing the certified health status record to the access requirement; determining an access determination according to one or more access-evaluation parameters comprising a disease identifier, a test type, a sample-collection time, a test-result time, a time to live value, a vaccination date, an effective date range, a geographic rule, and a validity period; generating a machine-readable access object representing the access determination; and encoding, the machine-readable access object to suppress health-status information utilized in generating the access determination while preserving information indicating the access determination.

SYSTEMS AND METHODS FOR ENABLING CUSTOMERS TO OBTAIN VISION AND EYE HEALTH EXAMINATIONS

Resumen de: US20260301934A1

0000 Systems and methods are provided for eye health and vision examinations. A customer diagnostic center is configured to generate customer examination data pertaining to an examination of a customer's eye. The customer diagnostic center provides a user interface for communicating with a customer and ophthalmic equipment for administering tests to the customer. A diagnostic center server is configured to receive the customer examination data from the customer diagnostic center over a network and allow the customer examination data to be accessed by an eye-care practitioner. A practitioner device associated with the eye-care practitioner is configured to receive the customer examination data from the diagnostic center server and display at least a portion of the customer examination data to the eye-care practitioner. Customer evaluation data is generated pertaining to the eye-care practitioner's evaluation of the customer examination data. An eye health report is provided to the customer via the network.

WEARABLE MONITOR

Resumen de: US20260301939A1

The present disclosure relates to a wearable monitor device and methods and systems for using such a device. In certain embodiments, the wearable monitor records cardiac data from a mammal and extracts particular features of interest. These features are then transmitted and used to provide health-related information about the mammal.

TWELVE-LEAD ELECTROCARDIOGRAM USING A THREE-ELECTRODE DEVICE

Resumen de: US20260294316A1

0000 An apparatus includes an electrocardiograph device having first, second, and third, electrode assemblies with first, second, and third electrodes adapted to measure first, second, and third electrical signals of an individual, respectively. The apparatus further includes a processing device to: determine a Lead I from the first electrical signal and the second electrical signal; determine a Lead II from the second electrical signal and the third electrical signal; generate a Lead III using (Lead III=Lead II−Lead I); determine, using a machine learning model trained using measured twelve-lead ECG data, Leads aVR, aVL, aVF, V1, V2, V3, V4, V5, and V6 based on Lead I, Lead II, and Lead III; and provide Leads Lead I, Lead II, Lead III, aVR, aVL, aVF, V1, V2, V3, V4, V5, and V6 for display on a client device.

PRE-FABRICATED ATTACHMENTS FOR MOLDS

Resumen de: US20260295904A1

0000 A system includes a mold of a dental arch of a patient. The mold includes teeth extending from a first distal end of the dental arch to a second distal end of the dental arch. An orthodontic aligner is to be formed over the teeth of the mold. The teeth of the mold are shaped to correspond to tooth-receiving cavities of the orthodontic aligner. The system further includes a pre-fabricated attachment. The pre-fabricated attachment and the mold are configured to removably engage with each other via one or more mold features of the mold and one or more attachment features of the pre-fabricated attachment.

Dental Appliance for Treatment of Bruxism And Sleep Apnea

Resumen de: US20260294672A1

0000 A dental appliance is disclosed. The appliance may include an arcuate base shaped to extend along at least a portion of an upper dental arch of a patient and match with a custom fit at least certain maxillary teeth of the patient. The appliance may further include a tongue-retention feature. The tongue-retention feature may connect to the arcuate base and comprise a palatal portion and a sublingual portion. The sublingual portion may cooperate with the palatal portion to form a cavity shaped to receive an anterior portion of a tongue of the patient therewithin. The palatal portion may have an exterior surface custom-formed to match at least a portion of a hard palate of the patient.

MEDICAL SERVICES KIOSK

Resumen de: US20260301938A1

0000 A medical services kiosk supporting private and secure telemedicine sessions between a patient and a remote network terminal utilized by a remote health care professional. The medical services kiosk comprising at least one privacy chamber having at least one door and at least one window. Each privacy chamber may include a user interactive display terminal that includes a display device, an input device, and a centralized processor, wherein the centralized processor is electronically communicable with the remote network terminal and a cloud based system. Each patient station may each include at least one documentation receiving device, at least one biometric device for obtaining biometric health measurements of the patient utilizing the at least one patient station, an arm mechanism, a seating mechanism, a camera, a retractable diagnostic camera device, a lighting mechanism that lights the privacy chamber, and a purification system.

CELLS, ISLETS, AND ORGANOIDS THAT EVADE IMMUNE DETECTION AND AUTOIMMUNITY, METHODS OF PRODUCTION AND USE THEREOF

Resumen de: US20260297530A1

0000 The invention features cells, islet-like cells, pancreatic islets and organoids (e.g., human islet-like organoids or HILOs), as well as cell cultures and methods that are useful for the rapid and reliable generation of cells and organoids, such as pancreatic islets and organoids, that are sustainable in vivo and that evade immune detection, rejection and autoimmunity. The invention also features methods of treating pancreatic diseases, such as type 2 diabetes, and pancreatic cancer, using the cells, islet-like cells, pancreatic islets and organoids (e.g., HILOs) that are designed to modulate the activity of immune cells that would otherwise react against them.

MEDICAL DEVICE FOR IDENTIFYING, IN PARTICULAR PRESENCE IDENTIFICATION, AND/OR CLASSIFYING A MEDICAL ITEM

Resumen de: US20260301909A1

0000 A medical device is configured to identify, in particular to identify the presence of, and/or classify, a medical item. The medical device includes an excitation unit configured to excite a medical item with at least one excitation so that the medical item vibrates. A detection unit detects a sound emission from the excited medical item. An evaluation unit identifies and/or classifies the medical item by analyzing the sound emission, preferably to identify whether the medical item corresponds to at least one predetermined medical item.

CLOSED-LOOP EXTERNALLY POWERED ELECTRICAL CORTICAL STIMULATIONS (XCS)

Resumen de: US20260295258A1

The present disclosure relates dynamic closed-loop neuromodulation techniques to induce an externally powered electrical cortical stimulation (XCS) configured for various applications by leveraging real-time neural data of a subject. The neural data may be collected by one or more neuromodulation devices, placed epidurally through surgical implantation into a skull. A brain state may be estimated by processing the neural data via analytical techniques. Based on the predicted brain state, a set of stimulation parameters, associated with the XCS for a cortical region, may be determined. This determination may rely on a state transition model, configured to learn how brain transitions from one brain state to another based on the ongoing neural activity. The brain responses to applied XCS may be monitored from the neural data collected in real-time. Based on the monitoring, one or more stimulation parameters may be dynamically adjusted for each XCS in a closed loop.

BIOPRINTING OF HIERARCHICALLY BRANCHING MICROVASCULAR NETWORKS

Resumen de: US20260295931A1

0000 A challenge to the clinical viability of large-scale tissue engineering is being able to perfuse entire constructs with blood supply that persists long-term. To accomplish this, tissue engineering needs to replicate the hierarchically branching networks of microvasculature that distribute homogeneous blood supply from arteries to capillary beds in natural tissues. Chaotic Printing can be adapted to extruding wide sheets of hydrogel containing hierarchically branching layers of multiple cell types that are native to vascular tissue. An in vitro “prevascularization” period can allow these cells to form into hollow tubular structures that mimic native microvasculature and can be perfused with blood supply. These prevascularized sheets can then be implanted in a subject to integrate with native arteries and veins and perfuse injured tissue with new blood supply.

METHOD OF MANUFACTURING A HEMIVALVE PROSTHESIS

Resumen de: EP4813352A1

0001 A method of manufacturing a patient-specific hemivalve prosthesis for mitral valve repair comprises segmenting a patient's mitral valve from medical imaging data to generate a segmented mitral valve model, creating an anterior leaflet model and a posterior leaflet model from the segmented mitral valve model by determining geometric references including a commissure-to-commissure line between two commissures, a coaptation line based on overlapping surfaces between the leaflet models, a posterior annulus connecting points along the posterior leaflet model adjacent to the left atrial wall, and a free edge line along points of the anterior leaflet in a ventricle underneath an annulus plane, reconstructing the posterior leaflet model by creating a neo-coaptation line to achieve a minimum target coaptation height, and forming the hemivalve prosthesis based on the reconstructed posterior leaflet model such that the prosthesis is configured to establish a coaptation plane with the patient's anterior leaflet.

VENTRICULAR TACHYCARDIA EXIT SITE IDENTIFICATION METHOD AND APPARATUS

Resumen de: EP4813296A1

0001 To non-invasively identify a ventricular tachycardia exit site in a heart of a particular patient (107) using electrocardiogram signals and medical imagery for the particular patient, a control circuit (101) can be configured to access (205) a neural network (104) that has been trained (202) using a plurality of synthetic data examples (203) and to input information regarding the electrocardiogram signals and the aforementioned medical imagery for the particular patient to the neural network. The control circuit can then output from the neural network information that identifies a predicted ventricular tachycardia exit site in the heart of the particular patient.

SYSTEMS AND METHODS FOR CAPTURING, DISPLAYING, AND MANIPULATING MEDICAL IMAGES AND VIDEOS

Nº publicación: EP4813342A2 30/09/2026

Solicitante:

STRYKER CORP [US]
Stryker Corporation

Resumen de: EP4813342A2

0001 A surgical image capture and display system includes a handheld image capture and pointing device and a display assembly. An image is captured by an image sensor of the handheld device and displayed on the display assembly. The image sensor detects light emitted by one or more beacons of the display assembly. The system determines, based on the light emitted by the one or more beacons, a position or orientation of the handheld device relative to the display assembly. The system updates display of a graphical user interface comprising the image on the display assembly in accordance with the determined position or orientation of the handheld device.