Alerta

COLLAGEN-CONTAINING CURABLE FORMULATIONS

Resumen de: US2025295791A1

A conjugate made of collagen and a plurality of curable elastic moieties covalently attached thereto, a curable formulation (e.g., a bioink composition) that comprises the conjugate and additive manufacturing of a three-dimensional object which utilizes the curable formulation are provided. Also provided are methods/processes of additive manufacturing that employ collagen that feature a plurality of photocurable groups, in which the viscosity of a collagen-containing formulation is determined by manipulating an amount of the photoinitiator that is mixed with the collagen.

CHAOTIC PRINTING FOR THE PRODUCTION OF NON-FILAMENTOUS ARCHITECTURES

Resumen de: US2025296278A1

Disclosed are methods for preparing non-filamentous scaffolds (e.g., sheets) for cell or tissue culture. These methods can comprise providing at least a first printing composition (e.g., a bioink) and a second printing composition (e.g., a bioink or a fugitive ink); chaotic printing the first printing composition and the second printing composition to generate a microstructured precursor comprising a plurality of lamellar structures formed from the first printing composition and the second printing composition; extruding the microstructured precursor through a nozzle (e.g., a fan-shaped nozzle, a curved fan-shaped nozzle, or an annular nozzle) to produce a non-filamentous microstructured precursor; and curing the non-filamentous microstructured precursor to provide the non-filamentous scaffold for cell or tissue culture.

FUNCTIONALLY-DIVIDABLE ORODISPERSIVE DOSAGE FORM

Resumen de: US2025295593A1

A dividable tablet with a functional seam for functionally dividing the dividable tablet into substantially equivalent sub-dosage units along the functional seam. The functional seam is configured to subdivide the sub-dosage units into the same mass within a tolerance of about 3% or less, and typically of 1.0% or less. The functional seam is configured reduce the amount of lost material that separates from the divided sub-dosage units after division of the dividable tablet along the functional seam, to less than 3%, and typically less than 1.0%, and more typically less than 0.1% of the mass of the undivided dividable tablet.

ADJUSTABLE BRACE AND PROCESSES FOR MAKING AND USING SAME

Resumen de: US2025295513A1

An adjustable brace for stabilizing a body part of a patient and a method of fabricating such a brace is provided. In some embodiments, the adjustable brace comprises a first stabilizer having a first exterior surface, a first interior surface, a first thickness, and a plurality of first stabilizer guides; a second stabilizer comprising a second exterior surface, a second interior surface, a second thickness, and a plurality of second stabilizer guides; and at least one flexible lacing member extending along the first and second stabilizer guides, wherein the flexible lacing member adjustably secures the first stabilizer to the second stabilizer. Additional embodiments further include a closure mechanism to assist in the flexible lacing member adjustment.

MULTI-VALENT POLYMERIZABLE COMPOSITIONS AND METHODS OF PRODUCING AND USING THE SAME

Resumen de: US2025297052A1

The present disclosure provides photo-polymerizable components, photo-curable resins comprising one or more of such monomers, as well as polymeric materials formed from the photo-curable resins. Further provided herein are methods of producing the compositions and using the same for the fabrication of medical devices, such as orthodontic appliances.

3D PRINTING TRANSPARENT BIOINK FORMULATION

Resumen de: US2025295837A1

Bioink comprising modified fibers of MFC with a diameter of about 100-400 nm.

RADIATION-CURABLE COMPOSITION FOR USE IN A RAPID PROTOTYPING PROCESS OR A RAPID MANUFACTURING PROCESS

Resumen de: US2025297044A1

Polymerizable, radiation-curable compositions are provided and comprise (i) monomers and (ii) at least one further component, wherein the (i) monomers comprise (a) at least one urethane (meth)acrylate that is at least difunctional, (b) at least one monofunctional acrylate having an alicyclic group and/or at least one monofunctional methacrylate having an alicyclic group, and (ii) the at least one further component comprises (c) at least one photoinitiator for the UV and/or visible range or a photoinitiator system for the UV and/or visible range. The compositions are usable for producing, via a rapid prototyping, manufacturing, or tooling process, dental prosthetic parts, orthopaedic instruments, or dental pre-forms that have a flexural strength of greater than or equal to 75 MPa, a modulus of elasticity of greater than or equal to 2600 MPa, and/or a water absorption of less than 45 μg/mm3.

SURGICAL CLAMP

Resumen de: AU2024235637A1

A surgical clamp for providing a stable mechanical grasp and stabilisation of bone during an orthopaedic surgical procedure, comprising: a first arm comprising: an extended section comprising a mount at the distal end thereof; and a first jaw portion located at the distal end of the first arm; a second arm comprising: a fastening platform located at the proximal end of the second arm; and a second jaw portion located at the distal end of the second arm; engagement means comprising a bolt to engage the first arm with the second arm about a pivot point formed by the engagement means to provide relative rotation of the first and second arms between: an open configuration whereby first jaw portion and second jaw portion are urged apart; and a clamped configuration whereby first jaw portion and second jaw portion are urged into clamping engagement with the patient's bone in use during the surgical procedure; a fastening component comprising a fastening bolt and a fastening nut, adapted to engage the first and second arm into a locked clamped configuration about the bone of a patient during the surgical procedure; and a handle adapted to be gripped by a surgical assistance for stabilisation of the patient's joint or bone during the surgical procedure.

Impact Resistant Material

Resumen de: US2025297834A1

The current disclosure is directed to an impact resistant material made from a novel melanin composite. It has been found that using these composites allows for the production of effective ballistic protection and blast containment materials.

EQUINE NASOGASTRIC TUBE MODEL AND RELATED METHODS

Resumen de: US2025299602A1

Systems and associated method of fabrication of anatomically accurate animal training models can comprise fabricating at least one inverse anatomical feature representative of an anatomical feature in an animal's head, forming a mold of the animal's head, connecting the at least one inverse anatomical feature in the mold of the animal's head, filling the mold of the animal's head with a filling material, and removing the cast head from the mold.

CERAMIC PROCESSING FOR THE DIRECT MANUFACTURE OF CUSTOMIZED LABIAL AND LINGUAL ORTHODONTIC BRACKETS

Resumen de: US2025298391A1

A method of manufacturing customized ceramic labial/lingual orthodontic brackets by digital light processing, said method comprises measuring dentition data of a profile of teeth of a patient, wherein measuring dentition data is performed using a CT scanner or intra-oral scanner, based on the dentition data, creating a three dimensional computer-assisted design (3D CAD) model of the patient's teeth using reverse engineering, and saving the 3D CAD model on a computer, designing a 3D CAD bracket structure model for a single labial or lingual bracket structure, importing the 3D CAD bracket structure model into a Digital Light Processing (DLP) machine, directly producing the bracket by layer manufacturing.

ACOUSTIC FLUID-MEDIATED BOTTOM-UP BIOPRINTING DEVICE FOR FUNCTIONAL ORGANS WITH ULTRAHIGH CELL DENSITY AND PRINTING METHOD THEREFOR

Resumen de: US2025297202A1

An acoustic fluid-mediated bottom-up bioprinting device for functional organs with an ultrahigh cell density and a printing method are provided, the acoustic fluid-mediated bottom-up bioprinting device includes an array SAW chip, a printing container, a printing platform and a curing light source; the printing container is used for containing a printing ink; the printing platform is able to move upward and downward in the printing ink; the array SAW chip includes a plurality of interdigital electrodes; a central axis of each interdigital electrode deflects from a direction towards a center of the circle; the array SAW chip is in contact with the printing ink and is able to form a focused acoustic flow to aggregate the cells in the printing ink; the curing light source is able to expose a projection into the printing ink above the printing platform and cure the printing ink above the printing platform.

PROSTHETIC DEVICES HAVING PRESSURE SENSORS AND METHOD OF THEIR USE

Resumen de: WO2025199404A1

A sensor device for use with a prosthetic socket includes a base material with at least one flexible printed circuit board (PCB) secured to the base material, the PCB having a plurality of pressure sensors. The PCB may include a radial arrangement of multiple PCBs or a single PCB with an integrated sensor array connected to a main processing unit via a flat ribbon cable. Comfort cell sensors with embedded BLE pressure sensors may also be used. The sensor device is positioned between a prosthetic silicone liner and socket to measure interface pressure. The data is processed to generate a real-time 3D pressure heatmap and may also be processed into 3D surface models using backend processing pipelines. Visualization software supports UV mapping, heuristic pressure analysis, and GPU-accelerated rendering, while a mobile application enables real-time interaction with the data for prosthetic fit evaluation.

ASSEMBLY FOR CARRYING A DENTAL PROSTHESIS AND A METHOD OF MANUFACTURING THE SAME

Resumen de: WO2024104515A1

The object of the invention is an assembly for carrying a dental prosthesis and a method of manufacturing the same, wherein the assembly for carrying a dental prosthesis comprises a dental implant (1 ), a fixation screw (2), and a pillar (3) for fixing the dental prosthesis, where the pillar (3) comprises a first end (4) of the pillar, a second end (5) of the pillar opposite the first end (4) of the pillar, and a cavity (6) of the pillar, wherein the cavity (6) of the pillar opens at both the first and second ends (4,5) of the pillar and the first end (4) of the pillar is adjacent to the dental implant (1 ), wherein at least a part of the fixation screw (2) is located in the cavity (6) of the pillar and the fixation screw (2) is connected to the dental implant (1 ), wherein the cavity (6) of the pillar comprises a first side (7) of the cavity comprising a first section (8) of the cavity and a second side (9) of the cavity comprising a second section (10) of the cavity, wherein the first side (7) of the cavity is located closer to the first end (4) of the pillar than the second side (9) of the cavity and the cross-section of the first section (8) of the cavity is larger than the cross-section of the second section (10) of the cavity, wherein the fixation screw (2) comprises a head (11 ) of the fixation screw that is located in the first side (7) of the cavity.

Medical device based on bioceramics, its use as a synthetic bone graft and process for the preparation thereof

Resumen de: GB2639318A

The present invention relates to a medical device manufactured using the additive manufacturing process (3D printing). It is a medical device used preferably as a bone graft composed of a porous structure based on bioceramics based on β-tricalcium phosphate (β-TCP) or hydroxyapatite, which may or not contain nanostructures in its composition, for example: carbon nanostructures (graphene, graphene oxide, reduced graphene oxide, carbon nanotubes, etc.) and, in preferred embodiments, stem cells and polymeric membrane. Also, the present invention relates to the use of this device as a bone graft and the process of preparing this device.

FUNCTIONALLY-DIVIDABLE ORODISPERSIVE DOSAGE FORM

Resumen de: WO2024108084A1

A dividable tablet with a functional seam for functionally dividing the dividable tablet into substantially equivalent sub-dosage units along the functional seam. The functional seam is configured to subdivide the sub-dosage units into the same mass within a tolerance of about 3% or less, and typically of 1.0% or less. The functional seam is configured reduce the amount of lost material that separates from the divided sub-dosage units after divi sion of the dividable tablet along the functional seam, to less than 3%, and typically less than 1.0%, and more typically less than 0.1% of the mass of the undivided dividable tablet.

열성형 모델을 고정하기 위한 기술

Resumen de: MX2025006175A

The present disclosure discusses techniques for securing thermoform models, including a locator plate (1105, 601, 701) for receiving and securing individually unique dental models having a raised polygon cutout (502) together with a locator pin (603, 802), a system for thermoforming an orthodontic aligner, and methods thereof.

可术中调整的椎弓根钉导板

Resumen de: CN223365636U

本实用新型属于医疗器械领域，涉及一种可术中调整的椎弓根钉导板，包括横跨棘突的导板本体，导板本体端部固设有用于与脊椎骨面贴合的定位板，导板本体上设置有与规划置钉方向平行的导向柱，定位板上与规划置钉点相对应的位置开设有导向槽。本实用新型通过半开放式的定位方式，使定位具备了一定的自由度和灵活度，术中可以进行二次调整和定位，提高了置钉的精准性，且便于术中导板的取出，同时节省了耗材成本，适用于椎弓根钉内固定术中椎弓根钉的定位。

用于下颌运动记录设备的个性化夹具

Resumen de: CN223365542U

本实用新型公开了一种用于下颌运动记录设备的个性化夹具，涉及牙科器械技术领域，包括：口内粘接装置，包括第一板体和第二板体，所述第一板体设置有两块，每块所述第一板体均呈弧形，且与相邻下槽牙牙面的弧度相适配，两块所述第一板体分别用于粘接在两侧的下槽牙唇侧，所述第二板体位于下颌牙的唇侧，且两块所述第一板体分别固定连接在所述第二板体的两侧，所述第二板体与下颌牙唇侧之间的间距大于等于上颌牙的厚度；固定器，用于安装下颌运动记录仪的下颌传感器。本申请的技术方案通过将第二板体与下颌牙唇侧之间的间距设置为大于等于上颌牙的厚度，可确保深覆颌受试者在使用该装置时上颌牙与下颌牙侧向运动期间不会产生干扰。

一种用于分阶段骨再生的3D生物打印径向多孔支架及其制备方法

Resumen de: CN120678997A

本发明公开了一种用于分阶段骨再生的3D生物打印径向多孔支架及其制备方法，所述3D生物打印径向多孔支架可以提供仿生细胞微环境，以支持宿主修复细胞向缺损部位的渗透，并在植入后促进骨整合，此外，所述3D生物打印径向多孔支架中含有的双重生长因子的序贯释放和后期PO43‑和Ca2+的持续释放可以完成分阶段骨再生的三个关键步骤，能够实现高效骨再生，代表了一种有前景的仿生阶段性再生策略。

深层组织的体内打印

Resumen de: WO2024173885A1

Techniques for deep tissue in vivo printing are described. Some implementations of the disclosure relate to a method that includes: obtaining a biopolymer mixture including prepolymer material and a crosslinking agent encapsulated in carrier particles; delivering the biopolymer mixture to a subcutaneous or deep tissue target location of a subject; and transmitting with a bioprinting device, via transcutaneous application, radiation to the subcutaneous or deep tissue target location, the radiation configured to cause the carrier particles to release at least some of the crosslinking agent, the released crosslinking agent configured to cause the prepolymer material to form into a gel or polymeric matrix.

一种用于葡萄糖响应性DLP 3D打印胶原蛋白生物墨水、制备方法及应用

Resumen de: CN120678985A

本发明属于生物医用材料技术领域，具体涉及一种用于葡萄糖响应性DLP 3D打印胶原蛋白生物墨水、制备方法及应用。本发明提供了一种葡萄糖响应性DLP 3D打印胶原蛋白生物墨水；所述生物墨水在pH 7的生理条件下可制备具有良好的机械性能、保真度和抗降解能力的水凝胶；且该凝胶可在高血糖环境下进行响应性释放；释放的姜黄素可以清除细胞内ROS，调控巨噬细胞炎症因子表达，发挥抗氧化抗炎功效，并且凝胶材料还能够促进细胞的增殖、黏附、迁移，具有良好的生物相容性和生物活性；在为糖尿病创面治疗提供了兼具智能释药、力学适配与主动促愈功能的个性化解决方案。

一种基于FDM多材料3D打印的微电流面膜及其制备方法

Resumen de: CN120678663A

本发明公开一种基于FDM多材料3D打印的微电流面膜及其制备方法，所述微电流面膜包括薄膜电池层、支撑层、活性成分层和吸附层，通过采用多层叠覆式结构设计，各层之间相互配合，由内而外依次设置，各层面积按照面部的弧度和轮廓逐渐递减，通过正金字塔型逐级递减的面积设计增强微电流面膜的贴合度，根据面部轮廓更好地贴合皮肤，减少对面部的拉扯和不适感。所述微电流面膜的制备方法，基于用户面部扫描数据，并通过多维特征融合分析，将获取的数据进行整合分析，使得建立的三维模型更为自然和贴切用户的实际面部，实现精确定制微电流面膜，提高微电流面膜的贴合度和舒适性；同时采用了FDM多材料3D打印技术，支持多材料的精确组合和功能集成，增强微电流面膜的功效性和安全性。

一种氧化锌-氧化铝陶瓷骨修复支架的制备方法

Resumen de: CN120682021A

本发明涉及生物医学材料的技术领域，公开了一种氧化锌‑氧化铝陶瓷骨修复支架的制备方法；首先按照比例称取氧化铝造粒粉和酚醛树脂粉体，混合氧化铝造粒粉和酚醛树脂粉体，得到获得3D打印复合粉体；其次，将3D打印复合粉体通过选择性激光烧结设备，制备得到氧化铝陶瓷坯体；将氧化铝陶瓷坯体进行干燥，得到干燥后的陶瓷坯体，并将干燥后的陶瓷坯体进行脱脂和烧结处理，冷却得到氧化铝预成型体；最后，使用纳米氧化锌溶胶对所述氧化铝预成型体进行真空压力浸渗，并引入动麦优化算法对真空压力浸渗参数进行优化，得到氧化锌‑氧化铝陶瓷骨修复支架；本发明通过制备工艺和智能优化工艺参数得到氧化锌‑氧化铝陶瓷骨修复支架，方法客观准确。

使用三维模型制造物体的方法和系统

Nº publicación: CN120680723A 23/09/2025

Solicitante:

广州黑格智造信息科技有限公司

Resumen de: CN120680723A

本申请涉及一种三维模型制造物体的方法和系统。上述方法包括：获取多个待打印的三维模型，三维模型包括模型关联信息，根据模型关联信息将各三维模型存储至一个或多个存储单元中，从指定存储单元中自动抓取至少一个目标三维模型，对目标三维模型进行排版处理，得到排版结果，基于排版结果，对目标三维模型进行三维打印。采用本方法能够能够在三维模型文件设计完成后，分类存储，自动抓取数据，自动完成前处理，并自动下发至三维打印设备进行三维打印，全程无需人工任何操作，提高三维模型的打印效率。