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一种防移位自适应自锁式人体管腔支架与制作方法

Resumen de: CN120078562A

本发明涉及一种防移位自适应自锁式人体管腔支架与制作方法，属于医疗器械领域。本发明包括支架单元和连接单元，相邻支架单元通过连接单元连接，其结构特点在于：所述支架单元包括呈菱形结构设置的主体框架、以及设置在主体框架内部的连接横梁、过渡横梁和榫卯横梁，所述连接横梁、过渡横梁和榫卯横梁依次连接，所述连接横梁和榫卯横梁均与主体框架连接，两个榫卯横梁上均设置有多个榫头，相邻榫头之间形成榫槽，其中一个榫卯横梁上的榫头与另一个榫卯横梁上的榫槽连接，其中榫头的数量不少于3个，榫槽的数量不少于2个。

一种牙齿修复装置

Resumen de: CN120078618A

本发明公开一种牙齿修复装置，涉及医疗器械技术领域，包括支撑板，支撑板顶面固定安装有操作台，操作台上设有用于设置参数的触摸显示屏，操作台内安装有3D打印机，操作台上开设有第二凹槽，第二凹槽内放置有扫描仪，扫描仪用于对患者口腔进行非接触式扫描，操作台远离扫描仪的一侧开设有第一凹槽，第一凹槽内放置有安装笔，安装笔用于将修复体装入需要修复的牙齿内，操作台上开设有盛放槽，盛放槽用于放置修复体。本发明能够一次性完成从扫描到安装的全过程，显著缩短治疗周期，提高效率；减少就诊次数和手术创伤，提升患者治疗体验，增强舒适度；通过安装笔对修复体进行固定安装，保证与牙齿良好的贴合度。

一种3D打印骨小梁口腔种植体的方法

Resumen de: CN115740495A

The invention relates to a method for 3D printing of a bone trabecula oral implant. The bone trabecula oral implant comprises an implant base body and a bone trabecula porous structure which are integrally formed. The bone trabecula porous structure is positioned in the axial middle section of the implant base body; and the implant base body is provided with an external thread. The printing method comprises the following steps: obtaining an oral implant 3D model with a bone trabecula porous structure through three-dimensional design software; carrying out molding manufacturing, sand blasting and annealing treatment by utilizing an SLM technology to obtain a bone trabecula oral implant primary product; and forming a tantalum metal coating on the surface of the primary product of the bone trabecula oral implant by using a vapor deposition technology to obtain the bone trabecula oral implant with the tantalum coating. The bone trabecula oral implant obtained by the method is high in density and mechanical strength, favorable for the implant to exert a good repairing effect, and excellent in application prospect.

一种3D打印生物墨水、矿化支架及制备方法和在矿化组织分级再生中的应用

Resumen de: CN120078947A

本发明提供了一种3D打印生物墨水、矿化支架及制备方法和在矿化组织分级再生中的应用，属于骨组织工程材料技术领域。本发明首先制备具有仿生形状和多孔网络的有机质微囊，通过引入多酚成核位点，矿化沉积迅速在微囊中发生，形成骨样羟基磷灰石纳米片聚集体，然后将其作为生物墨水的主要功能性单元，微囊经有机质连续相稳定组装，实现了植入体中矿化成核位点数量和生长域的个性化精准可控。通过3D打印制备矿化支架，本发明提供的矿化支架，在微囊内可形成丰富均质的矿化生长域，可有效促进间骨髓充质干细胞长入并形成矿化结节成为人工骨化中心，加快新生组织原位矿化和骨再生进程。

一种基于数字化导板引导的前牙分层树脂充填修复方法

Resumen de: CN120078530A

本发明属于口腔修复数字化领域，具体涉及一种基于数字化导板引导的前牙分层树脂充填修复方法。包括以下步骤：S1、获得基牙预备体的三维数字化模型；S2、利用口腔计算机辅助设计软件逐层生成缺损部分的牙本质形态的数字化模型；S3、在最后一层牙体缺损部分牙本质形态的数字化模型上完成牙釉质层形态的设计；S4、设计覆盖缺损牙邻牙的盖壳式导板，并对各盖壳式导板进行编号；S5、将各层模型和导板3D打印出来，并检查导板的就位情况；S6、在各级导板中填充相应的牙本质树脂和牙釉质树脂，将充填树脂的导板复位至口腔牙列，通过光照固化完成分层树脂充填。本发明优化了流程，简化了操作，充分利用数字化技术的优势保证了操作精度。

微针阵列和制造方法

Resumen de: WO2024040387A1

A microneedle array (101) comprises a surface (102) and two or more microneedles (104, 105) extending from the surface, wherein at least one of the microneedles has a different shape and/or length compared with a shape and/or length of at least one other of the microneedles. Furthermore method of making.

一种可紫外光固化的仿生半月板及其制备方法

Resumen de: CN120078942A

本发明公开了一种可紫外光固化的仿生半月板及其制备方法，涉及半月板组织替代物技术领域，仿生半月板的形状为模拟天然半月板的C形结构，仿生半月板的C形结构由前至后依次分为前部、中部和后部，仿生半月板的表面强度沿着前部到中部方向梯度增加，沿着中部到后部方向梯度下降；仿生半月板的C形结由内至外依次分为内侧、中间和外侧，仿生半月板的表面强度在前部和中部区域沿着外侧到中间方向梯度增加，沿着中间到内侧方向梯度下降；仿生半月板的表面强度在后部区域沿着外侧到内侧梯度下降；仿生半月板采用可紫外光交联的材料固化后制得。本发明使用紫外光固化材料制备不可降解的具有梯度强度分布的仿生半月板，其与天然半月板的力学性能相近。

SYSTEM AND METHOD FOR PRODUCING PHARMACEUTICAL OBJECTS VIA 3D PRINTING

Resumen de: EP4523890A2

The invention relates to a system for producing pharmaceutical objects, such as tablets, granules and capsules, via 3D printing. The system comprises a 3D printing machine (2) with a mechanical system (3) movable in one or more directions, at least one print head (5) with at least one nozzle (37) being movable by the mechanical system (3) and a base system (4) carrying a print base (6) for receiving a prepared mixture (27) applied by the print head (5) and comprising formatted print locations (49) on the base (6) for shaping the pharmaceutical object. The formatted print locations (49) can be adapted to receive a blister such that the pharmaceutical objects can be printed directly inside the blister. The system can further comprise a closing device for applying a sealing membrane or film to hermetically seal the blister after the printing is completed. The invention further relates to a method for producing pharmaceutical objects with the system.

TRANSPARENT, FRACTURE-RESISTANT POLYMERISATION RESINS FOR THE PRODUCTION OF DENTAL MOULDINGS

Resumen de: US2022370300A1

Radically polymerizable dental material, which contains at least one ABA or AB block copolymer, preferably at least one monofunctional, radically polymerizable monomer (a) and preferably at least one radically polymerizable urethane di(meth)acrylate telechel (b).

MODELEUR MAXILLAIRE

Resumen de: WO2024033402A1

The invention relates to a maxillary modeller (2) intended to be worn, in a service position, on a dental arch of a user in order to modify the shape of the palate, the maxillary modeller being one-piece and removable and comprising: - a central palatal portion (22) configured to be in contact with the user's palate when the maxillary modeller is in the service position; and - a first and a second dental portion (24; 26) each comprising at least one, preferably multiple cavities configured to receive teeth of the user when the maxillary modeller is in the service position, the first and second dental portions extending on either side of the central palatal portion, the central palatal portion being configured so as to exert on the palate, in the service position, forces suitable for modifying the shape thereof.

一种骨修复用3D打印聚乳酸复合支架及其制备方法

Resumen de: CN120053751A

本发明属于生物材料技术领域，具体涉及一种骨修复用3D打印聚乳酸复合支架及其制备方法。其中，骨修复用3D打印聚乳酸复合支架由以下原料制备而成：PLA/Mg‑ZrO2和BP/STAC；本发明采用PLA/Mg‑ZrO2作为3D打印支架，在PLA/Mg‑ZrO2支架表面形成BP/STAC复合涂层，制备得到骨修复用3D打印聚乳酸复合支架，PLA/Mg‑ZrO2支架具有模仿天然骨骼的分级孔隙率，PLA具有良好的生物相容性，Mg‑ZrO2的加入增强了PLA支架的力学强度和韧性，BP/STAC的复合涂层进一步增强了复合支架的力学性能，且有助于细胞附着和生长，加速了骨细胞的增殖和分化，促进新骨的形成。

薬物溶出外科用物品およびその使用方法

Resumen de: CN119546355A

A biological material comprising a first porous polymer, a second non-porous polymer, and a therapeutic agent, and a method of using the same for treating a condition are disclosed. The biomaterials disclosed herein may be, for example, surgical articles. Implanting the biomaterials disclosed herein in a subject can treat, for example, cancer.

CONTRAST MARKERS FOR USE IN MEDICAL PROCEDURES

Resumen de: WO2025111433A1

A contrast marker for use in medical imaging comprising: an elongated body comprising a first end and a second end, the second end opposite the first end, wherein a longitudinal axis is defined between the first end and the second end. A first portion of the elongated body is formed of a radiopaque material and a second portion of the elongated body is formed of a polymeric material, the first portion extending in a direction parallel with the longitudinal axis. The marker may be configured to receive a fluidic contrast medium so as to be imageable under CT and MR imaging. Also provided herein are methods of making the contrast marker. Further provided herein is an applicator plug for sealing a tubular brachytherapy applicator.

METHODS AND APPARATUS FOR REALISTIC 3D PRINTED PHANTOMS

Resumen de: WO2025111571A1

An apparatus includes a 3D model of a soft tissue. The 3D model includes an anatomically correct outer wall defining an internal cavity. The 3D model further includes a reduced scale duplicate of the outer wall positioned with in the internal cavity. The reduced scale duplicate divides the internal cavity into an inner chamber within the reduced scale duplicate and an outer chamber between the reduced scale duplicate and the outer wall. The 3D model further includes ports extending from each of the inner chamber and the outer chamber to an exterior of the outer wall. Each port is configured to connect to a device that is configured to inject liquids into each of the inner chamber and the outer chamber.

COMPOSITE RESIN FOR ESTHETIC RESTORATION WITH IMPROVED ANTIBACTERIAL PROPERTY AND POLYMERIZATION DEPTH, ANTIMICROBIAL AND ANTIVIRAL 3D PRINTING DENTURE BASE RESIN COMPOSITION, AND MANUFACTURING METHOD THEREFOR

Resumen de: WO2025110384A1

The present invention relates to a composite resin for esthetic restorations with improved antimicrobial properties and polymerization depth, and a manufacturing method therefor, wherein the compositive resin comprises urethane dimethacrylate (UDMA), bisphenol A-glycidyl methacrylate (BIS-GMA), bisphenol A dimethacrylate ethoxylated (BIS-EMA), triethylene glycol dimethacrylate (TEGDMA), a photoinitiator, a co-photoinitiator, a filler, barium glass, an accelerator, an antioxidant, a discoloration inhibitor, and an antimicrobial agent in addition to lysozyme. With the enhanced polymerization depth, the resin can be applied as a bulk-fill resin, and the excellent antimicrobial properties thereof provide resistance against bacteria and viruses. After polymerization, the resin exhibits a flexural strength exceeding 80 MPa, which is a level required by the Korean Ministry of Food and Drug Safety.

BIO-INK FOR PROMOTING MICROANGIOGENESIS, METHOD FOR PREPARING SAME, AND USE THEREOF

Resumen de: WO2025107170A1

Disclosed are a bio-ink for promoting microangiogenesis, a method for preparing same, and use thereof. The bio-ink is prepared by the following method: 1) preparing a filamentous microgel with a diameter within 20 microns from a sacrificial-phase material A as a porogenic template; 2) seeding vascular endothelial cells and perivascular cells on the surface of the filamentous microgel to give a hydrogel microfilament with the surface loaded with cells; and 3) mixing the hydrogel microfilament with the surface loaded with cells with a solution of a matrix-phase material B to give the bio-ink for promoting microangiogenesis. The bioprinting using the bio-ink can construct a capillary-like structure and cross-scale microvessels. The present invention can achieve the preparation of a micro-channel porous hydrogel structure with an average diameter of 20 microns or less and controllable porosity and the formation of a capillary-like network structure.

バイオプリント線維構造を製造するためのシステム及び方法

Resumen de: AU2023271390A1

Aspects of the disclosure include a fabrication platform for supporting a bioprinted fiber structures during printing, patterning, and/or processing, comprising a frame with a plurality of posts for securing a cross-linkable fiber during printing thereof, and where a continuous length of the cross-linkable fiber is printed around a plurality of posts during the 3D bioprinting process. The fabrication platform enables the cross-linkable fiber to be suspended during one or more of printing, patterning, and/or processing. In this way, the bioprinted fiber structure comprises a uniform outer surface, and can be easily modified and/or further processed after printing and patterning are completed.

一种仿生型种植桥架

Resumen de: CN120053114A

本申请公开了一种仿生型种植桥架，属于种植桥架领域。仿生型种植桥架包括种植体和连接体；种植体包括多个，每个种植体适配一个人体常规牙齿形状；多个种植体按人体常规牙齿顺序排列，相邻两个种植体之间通过连接体连接；每个种植体从牙尖至牙根的方向由实体结构向第一多孔结构变化以使弹性模量降低；每个种植体从牙齿中心至边沿的方向通过增加孔隙率使弹性模量降低；通过降低孔隙率使作为切牙、尖牙和磨牙的种植体的牙本质的弹性模量依次增加。本申请在采用同一种材料制作仿生型种植桥架的同时，实现根据人体生理牙齿不同位置具有不同的弹性模量，与人体生理牙齿实际弹性变形情况一致化，具有仿生学设计。

一种精确压低前牙的正畸矫治器的制作方法及正畸矫治器

Resumen de: CN120056314A

本申请涉及一种精确压低前牙的正畸矫治器的制作方法及正畸矫治器，精确压低前牙的正畸矫治器的制作方法包括根据数字化牙颌模型至少确定覆颌数值、覆盖数值和咬合平面，以及根据覆颌数值确定的需求压低量；确定预设覆盖阈值，根据预设覆盖阈值和覆盖数值之间的第一对比结果，确定对应的压低平台类型；确定预设压低量，根据预设压低量和需求压低量的第二对比结果，确定是否执行分阶段压低操作，若执行分阶段压低操作，则确定分阶段压低操作中的每个阶段压低量，分阶段压低量能基于用户交互窗口进行动态调整。不仅可以针对不同覆颌程度的患者提供个性化的矫治方案，还能确保压低量的精确控制，从而避免传统方法中因压低不准导致的反复调整问题。

通过喷射打印生产牙科修复体的方法、装置和系统

Resumen de: CN120056232A

本发明涉及通过喷射打印生产牙科修复体的方法、装置和系统。本发明提供一种通过喷射打印生产牙科修复体的方法，包括以下步骤：使用具有彼此不同颜色的多种不透明陶瓷浆料来喷射打印(S101)牙科修复体的牙本质核；以及使用半透明陶瓷浆料来喷射打印(S102)牙科修复体的牙齿釉质。

通过喷射打印生产牙科修复体的方法、装置和系统

Resumen de: CN120056234A

本发明涉及通过喷射打印生产牙科修复体的方法、装置和系统。本发明提供一种通过喷射打印来生产牙科修复体的方法，包括以下步骤：借助于陶瓷浆料喷射打印(S101)牙科修复体的一个或多个层；以及将半透明度增强剂和/或不透明度增强剂喷射打印(S102)至一个或多个层上。

通过喷射打印生产牙科修复体的方法、装置和系统

Resumen de: CN120056235A

本发明涉及通过喷射打印生产牙科修复体的方法、装置和系统。本发明提供一种通过喷射打印来生产牙科修复体100的方法，包括以下步骤：借助于陶瓷浆料喷射打印(S101)牙科修复体的一个或多个层；以及将着色溶液喷射打印(S102)至一个或多个层上。

基于3D打印的复合人工骨及其制备方法

Resumen de: CN120053753A

本发明公开了一种基于3D打印的复合人工骨及其制备方法。复合人工骨的制备方法包括步骤：(1)将聚己内酯和磷酸钙混合并制为丝材；(2)按照预设模型，使用所述丝材打印成型得到3D打印多孔支架，所述多孔支架具有孔道结构；(3)将填充浆料注入所述多孔支架的孔道结构中，所述填充浆料含有胶原蛋白和磷酸钙，干燥，获得成型的复合人工骨；(4)将复合人工骨和交联剂进行化学交联，交联后清洗，干燥，获得复合人工骨产品。该复合人工骨具有较优的力学强度，可以有效促进大段骨缺损、骨不连治疗过程中的早期血管及新骨生长。

一种新型钛钽合金牙科种植体材料及其制备方法和应用

Resumen de: CN120055291A

本发明提供一种新型钛钽合金牙科种植体材料及其制备方法和应用，该制备方法包括以下步骤：S1.准备钛钽合金粉末，按质量百分比计包括以下元素成分：Ta：30‑50％、余量为Ti，待用；S2.建立牙科种植体三维模型，使用选择性激光熔化将S1所述钛钽合金粉末制备得到目标，所述3D打印激光功率为200‑350W，扫描速度为600‑800mm/s，层厚为20‑40μm，得到牙科种植体，待用；S3.对S2所得牙科种植体进行等离子体表面处理，功率为100‑300W，时间为10‑20min，即得所述新型钛钽合金牙科种植体材料。所得新型钛钽合金牙科种植体材料具有较低的弹性模量、优异的力学性能和生物相容性，能促进细胞增殖，显著改善了种植体的生物力学性能，兼顾耐用性和减轻应力屏障效应，特别适用于高要求临床场景。

一种骨修复支架及其制备方法与应用

Nº publicación: CN120053748A 30/05/2025

Solicitante:

江苏省苏北人民医院

Resumen de: CN120053748A

本发明公开一种骨修复支架及其制备方法与应用。所述骨修复支架由磷酸镁支架在钾盐溶液中养护而成，磷酸镁支架的原料包括磷酸三镁和打印墨水载体，磷酸三镁为三水磷酸氢镁和氢氧化镁，打印墨水载体由明胶溶液、甘油和戊二醛溶液制得。所述骨修复支架的制备方法包括：用三水磷酸氢镁和氢氧化镁制备磷酸三镁粉末；将明胶水溶液、甘油、戊二醛溶液混合均匀，得到打印墨水载体；将磷酸三镁粉末与打印墨水载体混合，并进行垂直沉积3D打印，得到磷酸镁支架；将磷酸镁支架置于磷酸氢二钾溶液中养护，得到磷酸镁骨修复支架。本发明提供的骨修复支架，能够达到力学强度高、孔隙率高的效果。