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具有集成读出的传感器阵列

Resumen de: TW202532824A

A deformable sensor array may include a plurality of sensors and a flexible substrate. Each sensor of the plurality of sensors may include a sensor die to generate an analog signal and an converter die to perform analog-to-digital conversion (ADC) of the analog signal to generate a digital output. The flexible substrate may include electrical interconnect coupled with the plurality of sensors, and strain relief cutouts between sensors of the plurality of sensors and between the electrical interconnect, to enable deformation of the plurality of sensors. Other aspects are also described and claimed.

髋臼杯假体以及髋臼杯假体的制备方法

Resumen de: CN122681627A

本发明提供了一种髋臼杯假体以及髋臼杯假体的制备方法，其中，髋臼杯假体包括：金属杯主体，具有内腔以及与内腔连通的开口，开口用于使关节柄假体的球头伸入至内腔内；陶瓷涂层，覆盖在内腔的内壁面上；羟基磷灰石涂层，覆盖在金属杯主体的外壁面上，其中，羟基磷灰石涂层包括叠置设置的多个第一层结构，由远离至靠近金属杯主体的方向上，多个第一层结构的钙磷比逐渐减小。本申请的技术方案能够有效地解决相关技术中的难以兼顾加工工艺和稳定性的问题。

GEOGRAPHICALLY DISTRIBUTED DENTAL CARE MANAGEMENT SYSTEM FOR TREATMENT COORDINATION, TRANSPARENT ALIGNER FABRICATION, AND SPECIALIST COLLABORATION

Resumen de: WO2026181074A1

A system and method for managing dental treatment across geographically distributed clinics utilize a digital imaging module to capture intra-oral digital scans. A treatment planning module formulates a dental treatment plan validated by a remote orthodontic specialist. A patient management module orchestrates a competitive tender process to select an executing general dentist from a plurality of candidates based on weighted criteria comprising cost, proximity, and performance ratings. A manufacturing module interfaces with distributed laboratories for aligner fabrication. In some embodiments, the system incorporates a blockchain network with smart contracts for milestone-based financial execution and an artificial intelligence module for predictive treatment optimization. A real-time interactive aligner device comprising electromechanical micro-actuators enables remote geometric adjustments of the aligner in response to specialist instructions. A communication interface facilitates continuous feedback and oversight between patients, specialists, and selected providers, ensuring unified clinical quality and operational efficiency across the distributed network.

DIAGNOSING AND TREATMENT UVEAL MELANOMA

Resumen de: WO2026183498A1

The present disclosure relates to methods for diagnosing and treating uveal melanoma.

MACHINE LEARNING MODELS TO PREDICT GLAUCOMATOUS DAMAGE

Resumen de: WO2026183445A1

Presented herein are systems and methods of determining likelihoods of neurodegenerative vision loss in eyes due to glaucoma. A computing system may receive, for a subject at risk of neurodegenerative vision loss in an eye due to glaucoma, a dataset. The dataset includes a first biomedical image of the eye associated with the subject at a first intraocular pressure (IOP), a second biomedical image of the eye associated with the subject at a second IOP, and a plurality of characteristics associated with the subject. The computing system may apply a machine learning (ML) architecture on the dataset. The computing system may determine, based on applying the dataset to the ML architecture, a predicted metric in the eye of the subject. The computing system may generate, using the predicted metric, a score indicating a likelihood of neurodegenerative vision loss in the eye due to glaucoma.

APPARATUS AND METHODS FOR NEURAL STIMULATION USING POLYNOMIAL DISTORTION ALGORITHM

Resumen de: WO2026183411A1

Exemplary embodiments of the present disclosure include apparatus, methods and systems for therapeutic neuromodulation of neurons and circuits utilizing a polynomial distortion algorithm (PDA). Exemplary embodiments provide for selective activation of specific model neurons by PDA tuning of the stimulating waveform to the intrinsic biophysical properties of the neuron. Furthermore, exemplary embodiments provide energy optimization of the waveform that can minimize off-target effects. Selective activation of specific model neurons can be achieved by PDA tuning of the stimulating waveform to the intrinsic biophysical properties of the neuron. Furthermore, energy optimization of the waveform can minimize off-target effects. Apparatus and methods utilizing a polynomial distortion algorithm to stimulate neurons with different channel activation properties, channel conductance properties, and diameters are provided.

SYSTEMS AND METHODS FOR PRIORITIZING DIGITAL THERAPEUTIC CONTENT BASED ON COMPREHENSIVE ASSESSMENT TEST RESULTS

Resumen de: WO2026183009A1

Presented herein are systems and methods for prioritizing digital therapeutic content based on comprehensive assessment test results. A computing system can maintain a patient profile for each patient of a plurality of patients including results data corresponding to a comprehensive assessment test testing across a plurality of domains. The computing system can maintain a plurality of task objects, each task object corresponding to at least one of the plurality of domains. The computing system can assign a rank to each domain based on the respective domain-specific result data. The computing system can generate a treatment plan including one or more task objects, wherein each task object is selected or arranged based on whether the task object corresponds to a group of domains. The computing system can provide data corresponding to the one or more task objects in accordance with the treatment plan.

A MICROFLUIDIC DEVICE FOR MODELLING VASCULATURE ACTIVITY AND A METHOD OF FORMING THEREOF

Resumen de: WO2026178602A1

A patient-specific microfluidic device for modelling thrombotic response and method of making thereof. The device includes a flow channel having a geometry that substantially corresponds to a patient's vascular geometry in a region of interest, said geometry derived from one or more clinical images associated with the patient. The device includes endothelial cells lining at least a portion of the flow channel, and at least one portion of laser-induced injury corresponding to an identified injury site of the patient or a desired injury site for modelling.

COMPOSITIONS AND METHODS FOR TREATING KIDNEY DISEASES IN PETS

Resumen de: WO2026181069A1

Methods of culturing renal cells of pets are provided. Also provided are methods of producing spheroids and organoids from pet renal cells and uses thereof in regenerating renal function.

Dissolvable Pore Reinforcement For Surface Overmolding

Resumen de: US20260256590A1

0000 A method of manufacturing an implant including additively manufacturing the implant from a first material such that the implant defines a plurality of pores. Then inserting a filler material into the pores after the implant has been manufactured. Next, overmolding the implant with a second material after the filler material has been inserted the pores, and then dissolving the filler material from the pores prior to deployment of the implant.

SYSTEMS AND METHODS FOR OPTIMIZED RETINAL IMAGE CAPTURE USING DUAL-STAGE AI-BASED QUALITY ASSESSMENT

Resumen de: WO2026183110A1

Disclosed in an integrated retinal imaging system designed to enable high-quality, diagnostic image capture with minimal operator intervention. The system can implement a dual-stage Holistic Quality Assessor (HQA), with HQA-1 performing real-time, holistic quality assessments on infrared or near infrared image frames to detect optimal capture conditions, and HQA-2 verifying the diagnostic adequacy of a captured color image. Both HQA-1 and HQA-2 can leverage machine learning or deep-learning models executed on a local hardware accelerator and are configured to provide low-latency and accurate evaluations. By combining dual-stage quality assessment with real-time capture optimization, the system can enable reliable, diagnostic-quality image capture across various clinical settings and user experience levels.

METHOD FOR PREPARING CERAMIC SLURRY FOR PHOTOCURABLE 3D PRINTING

Resumen de: WO2026182384A1

The present invention relates to a method for preparing a ceramic slurry for photocurable 3D printing and, more specifically, to a method for preparing a ceramic slurry for photocurable 3D printing, in which ceramic or glass-ceramic powder is used such that a dental prosthesis can exhibit esthetics similar to those of a natural tooth and, furthermore, a non-reactive diluent is included so that a low-viscosity slurry can be prepared even while containing a high amount of the ceramic or glass-ceramic powder, wherein the slurry thus prepared is easily moldable using 3D printing, can be manufactured into a high-quality three-dimensional sculpture during 3D printing, has high precipitation stability during storage, and can maintain the viscosity even during a 3D-printing process.

MATERIAL EXTRUSION 3D PRINTING PROCESS FOR BIODEGRADABLE MAGNESIUM ALLOY

Resumen de: WO2026182531A1

The present invention provides a 3D printing process for a magnesium alloy, comprising: a step of manufacturing an extrusion material comprising a magnesium alloy powder and a binder; a step of extruding the extrusion material so as to form a molded body; and a sintering step of sintering the molded body in a hydrogen-containing inert gas atmosphere. According to the process of the present invention, carbon by-products can be minimized during sintering and good interparticle bonding can be achieved, and thus a customized 3D-printed body having excellent physical properties can be provided.

3D Bioprinted Model for Quantifying Neurite Outgrowth

Resumen de: US20260258350A1

A three-dimensional (3D) bioprinted model of a forebrain cortex is designed to quantify neurite outgrowth across a hydrogel bridge. The 3D bioprinted model includes two cell-laden compartments formed using a first hydrogel matrix, separated by a hydrogel bridge formed from a second, stiffer hydrogel matrix. The model may fit within standard 96-well plate formats, enabling medium-throughput screening applications. The model was validated using Alzheimer's disease forebrain cortical populations, demonstrating significant reductions in neurite outgrowth from Alzheimer's disease populations compared to controls.

ROBOTIC SURGICAL SYSTEM AND METHOD FOR USING ARTIFICIAL INTELLIGENCE TO GENERATE SIMULATION AND DECISION SUPPORT FOR TELEOPERATION

Resumen de: US20260256534A1

0000 A robotic surgical system and method for using artificial intelligence to generate simulation and decision support for teleoperation are provided. In one embodiment, the robotic surgical system provides a surgical simulation model with input about a surgical field of a patient and signals generated in response to user-manipulation of the plurality of user input devices to perform a surgical task on the patient. The surgical simulation model generates and displays a video that represents a simulated performance of the surgical task. Other embodiments are provided.

SYSTEMS AND METHODS FOR FABRICATING ORTHODONTIC RETAINERS

Resumen de: US20260256560A1

The present disclosure provides systems and methods for fabricating an orthodontic retainer comprising a retainer base. The methods may include obtaining a first digital model representing the palate and the upper teeth of a patient. The methods may include creating, based on the first digital model, a second digital model representing the retainer base and a third digital model representing a teeth shell, and creating, based on the second digital model and the third digital model, a fourth digital model representing the retainer base and the teeth shell that are connected via a connecting structure. The methods may include generating a printed assembly by printing the fourth digital model using a first curable resin material. The printed assembly may at least include the retainer base, the teeth shell, and the connecting structure. The methods may include post-processing the printed assembly to obtain the retainer base.

MODEL-RECEIVING BODY FOR FASTENING A JAW MODEL

Resumen de: WO2026180184A1

The invention relates to a model-receiving body (1) for fastening a jaw model (2) in an articulator (3), wherein: the model-receiving body (1) has a first side (4) for fastening the jaw model (2) and a second side (5) opposite the first side (4); the model-receiving body (1) has a plurality of bearing bars (6) for the jaw model (2) and a fastening device (7) for magnetically fastening the model-receiving body (1) to the articulator (3) or to an adapter plate (8); open spaces (9), which are open towards the first side, are formed between the bearing bars (6) in the model-receiving body (1), and the bearing bars (6) have bearing surfaces (10) for supporting the jaw model (2) in a first direction (11) pointing away from the second side (5); the model-receiving body (2) has at least two, preferably three, position-securing pins (12), which are arranged at a distance from one another and project beyond the bearing surfaces (10) in the first direction (11), for aligning the jaw model (2) in two directions (13, 14), which are orthogonal relative to the first direction (11) and also relative to one another.

FUNCTIONALIZED RECOMBINANT BACTERIAL COLLAGEN-LIKE PROTEINS

Resumen de: US20260258096A1

Recombinant bacterial collagen-like protein, preferably with an amino acid sequence that is at least ≥60% identical to the amino acid sequence of SEQ ID NO:1 wherein the amino acid sequence comprises a deletion of at least 38 amino acids at the N-terminus of the amino acid sequence of SEQ ID NO:1, wherein the recombinant collagen-like protein is functionalized with at least one non-terminal alkene group. A bioink comprising the functionalized recombinant bacterial collagen-like protein, at least one solvent and at least one photoinitiator, a process for producing a hydrogel by crosslinking the functionalized recombinant bacterial protein or the bioink as well as the hydrogel obtained therefrom. Furthermore, a scaffold for tissue engineering comprising the hydrogel.

SYSTEMS AND METHODS FOR MONITORING PATIENT INTERFACES

Resumen de: US20260257027A1

In one form of the present technology, a system for analysing a high flow respiratory therapy, may comprise: a blower; a nasal cannula, wherein a flow of gas travels from the blower to the nasal cannula along a flow path during administration of the high flow respiratory therapy; a sensor disposed along the flow path; and a processor configured to perform steps to: receive data from the sensor; compare the data received from the sensor to a threshold value; based at least in part on the comparison, determine whether the nasal cannula is mispositioned on a patient or displaced from the patient; and upon determining the nasal cannula is mispositioned on the patient or displaced from the patient, transmit an alert indicating that the nasal cannula is mispositioned on the patient or displaced from the patient.

REINFORCED PROSTHETIC DEVICE

Resumen de: US20260256600A1

0000 The present invention is directed to a novel 3D printed prosthetic sockets having one or more internally positioned support struts configured to counter the structural instability at the distal ends of the socket and prevent undesired sheering forces that can result structural failure of the socket.

IMPLANTABLE NEURO MODULATOR DEVICE AND SYSTEM COMPRISING SUCH AN IMPLANTABLE NEURO MODULATOR DEVICE

Resumen de: US20260257071A1

An implantable neuro-modulator device, including a hermetically sealed housing, wherein an antenna for communicating with external devices and/or for wirelessly receiving electrical energy is positioned within the housing, wherein a major part of the housing is electromagnetically transparent to radiation in the frequency range below 20 MHz, in particular between 5 and 15 MHz.

Systems and Methods for Intraoral pH Monitoring

Resumen de: US20260256386A1

A system and method for monitoring pH of an intraoral device involves receiving the oral pH data from at least one pH sensor embedded within the intraoral device. The oral pH data is then correlated with one or more user related data to classify the oral pH data into one or more pre-defined categories indicative of a health condition. Further, the machine learning module generates feedback and/or recommendations for the user based on the classification of the oral pH data into one or more pre-defined categories. The oral pH data and/or feedback and/or recommendations are then communicated to the user and/or external device.

COMBINED FACE SCANNING AND INTRAORAL SCANNING

Resumen de: US20260256546A1

A system comprises an intraoral scanner, a three-dimensional (3D) image capture device, and a computing device operatively coupled to the intraoral scanner and to the 3D image capture device. The computing device receives intraoral scan data of a dental site of a patient generated by the intraoral scanner during intraoral scanning. The computing device further receives one or more 3D images of a face of the patient generated by the 3D image capture device during the intraoral scanning, wherein the intraoral scanner is captured in the one or more 3D images. The computing device registers the one or more 3D images of the face of the patient to the first intraoral scan data based at least in part on a first position of the intraoral scanner relative to the face of the patient in the one or more 3D images.

CLEAR ORTHODONTIC ALIGNER

Resumen de: US20260256547A1

0000 The present invention relates to a clear orthodontic aligner comprising at least one molecule capable of changing color or color intensity (CCM). Furthermore, the invention relates to a process for obtaining a clear orthodontic aligner by means of three-dimensional (3D) printing.

THREE-DIMENSIONAL PRINTING COMPOSITION AND METHOD OF PRODUCING DENTAL PRINTED ARTICLE

Nº publicación: US20260256559A1 03/09/2026

Solicitante:

GC CORP [JP]
GC Corporation

Resumen de: US20260256559A1

A three-dimensional printing composition includes: a polymerizable monomer; inorganic particles; and a photopolymerization initiator. The inorganic particles are surface-treated with a compound represented by a general formula (1)(in the general formula, R1 is a hydrogen atom or a methyl group; R2 is a hydrolyzable group; R3 is a hydrocarbon group having 1 or more and 6 or less carbon atoms; p is 2 or 3; and q is an integer of 5 or more and 13 or less).