Alerta

CONTROLLED-RELEASE FORMULATION FOR ORAL ADMINISTRATION COMPRISING MELATONIN, AND PREPARATION METHOD THEREFOR

Resumen de: WO2025114770A1

The present invention relates to an orally administered formulation comprising melatonin as an active ingredient and having a drug-release controlling property, and a method for preparing same by using 3D printing and relates to a pharmaceutical composition and a food composition, of the formulation, for preventing or treating jet lag, and a composition to be applied to a 3D printer.

PHOTOCURABLE RESTORATION COMPOSITION COMPRISING CERAMIC COMPOSITION AND DENTAL PROSTHESIS USING 3D PRINTER

Resumen de: WO2025116270A1

The present invention relates to: a photocurable restoration composition comprising a ceramic composition; and a dental prosthesis using a 3D printer. More specifically, the present invention relates to: a photocurable restoration composition comprising a silane-treated ceramic composition; and a dental prosthesis manufactured using the photocurable restoration composition by using a 3D printer. According to the present invention, it is possible to obtain a dental prosthesis having improved gloss, excellent thermal resistance and hardness, and improved uniformity and reliability.

POLYETHER-CONTAINING POLYMERIZABLE COMPOUNDS AND USE IN CURABLE RESIN COMPOSITIONS

Resumen de: WO2025117528A1

This disclosure provides polymerizable resin compositions comprising a hydrophobic polyether-containing polymerizable polyurethane compound to impart improved stain resistance to polymeric materials formed from the polymerizable resin compositions. Further provided herein are methods of producing the compositions and using the same for the fabrication of dental devices, such as orthodontic appliances.

Schablone für die Ausführung von Trennschnitten in Knochen bei chirurgischen Eingriffen und Verfahren zu ihrer Herstellung

Resumen de: DE102023133592A1

Die Erfindung betrifft eine Schablone (2) für die Ausführung von Trennschnitten mittels eines scheibenförmigen Trennwerkzeugs in Knochen bei chirurgischen Eingriffen, insbesondere für Femur- und Tibia Resektion, mit einem Grundkörper (4) und einer darin ausgebildeten schlitzförmigen Öffnung (6) zum Durchgreifen mittels des scheibenförmigen Trennwerkzeugs, wobei die schlitzförmige Öffnung (6) das scheibenförmige Trennwerkzeug beim Durchgreifen der schlitzförmigen Öffnung (6) führt, indem die schlitzförmige Öffnung (6) von einander gegenüberliegenden und vorzugsweise zueinander parallelen Wandungsabschnitten (16, 18) begrenzt ist, wobei wenigstens einer der Wandungsabschnitte (16, 18) und vorzugsweise beide Wandungsabschnitte (16, 18) in die schlitzförmige Öffnung (6) einragende, mit dem Trennwerkzeug in gleitenden Kontakt bringbare und das Trennwerkzeug hierdurch führende Erhebungen (20, 24, 32, 38, 42) und gegenüber den Erhebungen (20, 24, 32, 38, 42) zurückgesetzte Vertiefungen (22, 26, 34, 40, 44) aufweisen, welche aufgrund ihrer Zurücksetzung keinen gleitenden Kontakt zu dem Trennwerkzeug ausbilden können.

BIOPRINTED 3D CULTURE SCAFFOLDS

Resumen de: WO2025117593A1

A three-dimensional scaffold for use in engineered tissue includes a repeated 3D geometry; and at least one of a hydrogel, a biocompatible polymer, and a bioprintable polymer. The repeated 3D geometry may include an open geometry including a plurality of interconnected nodes configured to be seeded with living cells. The scaffold may be formed via bioprinting. The three-dimensional scaffold may also be used for (1) 3D tissue modelling (for liver, kidney, gut, pancreas, heart, lung, spleen, etc.), (2) disease modeling of different tumor types such as breast, colorectal, lung, liver, brain, ovarian and others, (3) drug testing / therapeutic screening of small molecule drugs, peptides, proteins, antibodies, ADCs, gene therapies, RNA-based therapeutics, cell therapies, and tissue therapies, and (4) therapeutic/drug delivery (i.e., via delivery device that can be used to control drug release based on different patterns).

METHODS AND SYSTEMS FOR GENERATING THREE-DIMENSIONAL BIOLOGICAL STRUCTURES

Resumen de: US2022389373A1

One aspect of the invention provides a method of generating three-dimensional biological structures. The method includes: (a) depositing a first layer of a suspension over a substrate, the suspension including a liquid and a plurality of cells; (b) allowing the plurality of cells to attach to the substrate and form a first layer of attached cells; (c) depositing a cell-attachment agent over the first layer of attached cells; and (d) depositing a second layer of the suspension over the cell-attachment agent.

FIXATION OF DYE SOLUTIONS IN MULTI-COLOR INK JET 3D CERAMIC PRINTING

Resumen de: EP4563115A1

Die vorliegende Erfindung betrifft ein Verfahren zum Herstellen einer dentalen Restauration durch Strahldruck, mit den Schritten eines Strahldruckens (S101) einer oder mehrerer Schichten der dentalen Restauration mittels eines keramischen Schlickers; eines Strahldruckens (S102) einer Färbelösung auf die eine oder mehreren Schichten; und eines Auftragens (S103) einer Fixierlösung zum Fixieren der Färbelösung.

MUSCLE ASSISTANCE MEMBRANE

Resumen de: WO2024022890A1

The invention relates to a muscle membrane intended to be affixed to a muscle of a human or animal body, the membrane being capable of at least partially surrounding the muscle, the muscle comprising fibres covered with an outer tissue, the positioned membrane having a shape that is identical to that of the muscle. The membrane is characterised in that it exhibits anisotropic behaviour so as to reproduce the mechanical behaviour of the muscle, the membrane comprising: - a matrix designed in a biocompatible material having an elasticity similar to that of the outer tissue of the muscle, - one or more reinforcing strips rigidly attached to the matrix, each strip being designed in a biocompatible material having an elasticity similar to that of the fibres it covers and each strip being oriented according to membrane stiffening requirements and according to the expected muscle correction.

INTERPENETRATING POLYMER NETWORKS FOR USE IN SUTURABLE AND FLEXIBLE MATERIALS

Resumen de: AU2023315783A1

An advanced manufactured interpenetrating polymer network (AM-IPN) comprising: a primary polymer network; a secondary polymer network, wherein the secondary polymer network is bonded to the primary polymer network via one or more crosslinks, wherein one or more of the primary polymer network, the secondary polymer network and the one or more crosslinks are printed using a synthetic bioink is disclosed. Methods of making and using are also disclosed.

IMPLANTS COMPRISING A SILICONE FOAM

Resumen de: WO2024026456A1

The present invention relates to a new silicone foam obtained from a blowable crosslinkable silicone composition comprising an organopolysiloxane having at least two alkenyl groups bonded to silicon per molecule, an organosilicon compound having at least two and preferably at least three hydrogen atoms bonded to silicon per molecule, a hydrosilylation catalyst, at least one porogenic agent which is water, a hydrogel, or an aqueous silicone emulsion, at least one chemical blowing agent, and a linear polydimethylsiloxane.

PRE-INKED SLIP FOR MULTI-COLOR INK JET 3D CERAMIC PRINTING

Resumen de: EP4563118A1

Die vorliegende Erfindung betrifft ein Verfahren zum Herstellen einer dentalen Restauration durch Strahldruck, mit den Schritten eines Strahldruckens (S101) eines Dentinkerns der dentalen Restauration mittels einer Mehrzahl opaker keramischer Schlicker, die zueinander unterschiedliche Farben aufweisen; und eines Strahldruckens (S102) des Zahnschmelzes der dentalen Restauration mittels eines transluzenten keramischen Schlickers.

SELECTIVE ADJUSTMENT OF HARDNESS AND TRANSLUCENCY IN MULTI-COLOR CERAMIC INKJET 3D PRINTING

Resumen de: EP4563116A1

Die vorliegende Erfindung betrifft ein Verfahren zum Herstellen einer dentalen Restauration durch Strahldruck, mit den Schritten eines Strahldruckens (S101) einer oder mehrerer Schichten der dentalen Restauration mittels eines keramischen Schlickers; und eines Strahldruckens (S102) eines Transluzenzverstärkers oder Opazitätsverstärkers auf die eine oder mehreren Schichten.

SELECTIVE STAINING BY STAINING SOLUTIONS IN 3D PRINTING

Resumen de: EP4563117A1

Die vorliegende Erfindung betrifft ein Verfahren zum Herstellen einer dentalen Restauration (100) durch Strahldruck, mit den Schritten eines Strahldruckens (S101) einer oder mehrerer Schichten der dentalen Restauration mittels eines keramischen Schlickers; und eines Strahldruckens (S102) einer Färbelösung auf die eine oder mehreren Schichten.

INTRAORAL COMPOSITE PRINTER

Resumen de: EP4563114A1

Die Erfindung betrifft das Fachgebiet der Zahnmedizin und bietet ein fortschrittliches Verfahren zur Applikation von fließfähigem Komposit auf Zähne. Hierzu dient ein System, das einen Applikator nutzt, welcher an einer intraoral fixierten Halteschiene angebracht ist. Dies ermöglicht eine präzise und kontrollierte Applikation des Komposits. Die Technologie stellt eine effiziente, automatisierte Lösung bereit, die sowohl für Frontzähne als auch für Backenzähne geeignet ist. Durch den Einsatz von Technologien wie Oberflächenscan, additiver Fertigung und automatisierter Bewegungssteuerung markiert diese Neuentwicklung einen bedeutenden Fortschritt in der Zahnmedizin und hat das Potenzial, die Qualität und Effizienz zahnmedizinischer Behandlungen erheblich zu verbessern.

System of multiple interlocking embedment

Resumen de: GB2635903A

An oral dosage tablet for delivery of hydrophobic active ingredients to a patient and method of forming the same are described. The oral dosage tablet includes one or more layers of an active ingredient adjacent one or more layers of a lipid, such as a phospholipid. The layers are alternating and have a thickness of between 0.1 and 0.8 millimeters. The method of forming the tablet includes forming a lipid paste and an active ingredient paste of the respective components and applying alternating layers of each in layers of between 0.1 millimeters to 0.8 millimeters. The oral dosage tablet is subsequently dried and stored until treatment commences.

DOUBLE NETWORKED 3D-PRINTED BIOMATERIALS

Resumen de: WO2024026023A2

A 3D-printed biomaterial is described that comprises a double-networked hydrogel comprising gelatin or gelatin methacryloyl and alginate, and cells. Methods of making the 3D-printed biomaterial by extruding a hydrogel comprising gelatin or gelatin methacryloyl and alginate from a 3D-printer and converting the hydrogel to a double-networked hydrogel by cross-linking the gelatin with a first cross-linking method and cross-linking the alginate with a second cross-linking method are also described. Methods of treating a damaged or diseased blood vessel and testing vasoactive drugs using 3D-printed blood vessels are also described.

SYSTEM AND METHOD FOR ENHANCED AEROSOL DRUG DELIVERY DURING HIGH FLOW NASAL CANNULA THERAPY

Resumen de: WO2024026093A1

A system and method for enhanced aerosol drug delivery during high flow nasal cannula (HFNC) therapy. The system comprises a breath enhanced jet nebulizer (BEJN) connected to a high flow medical breathing gas supply supplying breathing gas to the BEJN at flow rates of 5 L/min to 60 L/min, a nebulization gas supply, a drug infusion device that supplies a drug solution to the nebulizer for the delivery of nebulized drug to a patient. All the breathing gas and nebulized drug solution delivered to the patient passes through the BEJN. The rate of drug delivery increases with increases in the flow rate of the medical breathing gas supply and increases in infusion pump flow rates. The drug solution infusion rate is between 5 mL/hour and 50 mL/hour. This system and method enable efficient aerosol drug delivery to patients during HFNC therapy for prolonged periods, improving treatment outcomes.

BIOENGINEERING PATIENT-SPECIFIC 3D-PRINTED CARTILAGE IMPLANTS

Resumen de: WO2024028882A1

The invention related to an implant comprising a scaffold comprising at least one first area characterized by micropores and at least one second area characterized by macropores, wherein said at least one second area is defined by being expected to be exposed to higher pressures and/or forces when compared with said at least one first area, and methods thereof.

Drug-eluting surgical articles and methods of use thereof

Resumen de: GB2635973A

Disclosed herein is a biomaterial and a method of use thereof for treating a condition; the biomaterial comprises a first porous polymer, a second non-porous polymer, and a therapeutic agent. A biomaterial of the disclosure can be, for example, a surgical article. Implantation of a biomaterial disclosed herein into a subject can treat, for example, cancer.

用于基于光的生物打印应用的生物墨水水溶液以及使用该生物墨水水溶液的方法

Resumen de: WO2024084040A1

The disclosure relates to an aqueous bioink solution for use in light-based bioprinting applications, comprising: (a) 0.5-95 wt % water-soluble prepolymer; (b) 0.001-5 wt % biocompatible metal acylphosphinate photoinitiator; (c) 0.001-10 wt % biocompatible light absorber; and (d) 5 to 99.5 wt % solvent. The disclosure further relates to a method of using the aqueous bioink solution including living cells and a method of using the aqueous bioink solution without living cells (acellularly).

一种光敏树脂组合物、树脂牙及树脂牙的制备方法

Resumen de: CN120081983A

本发明提供了一种光敏树脂组合物、树脂牙及树脂牙的制备方法。所述光敏树脂组合物包括如下质量百分比的组分：聚氨酯(甲基)丙烯酸酯类低聚物20～45％、单官能(甲基)丙烯酸酯单体5％～15％、多官能(甲基)丙烯酸酯单体10～30％、填料15～55％、引发剂1％～5％、紫外线吸收剂0.02％～0.12％和光稳定剂0.1％～0.3％。所述树脂牙由所述光敏树脂组合物通过光固化3D打印制备得到。采用本发明提供的光敏树脂组合物制备的树脂牙具有在口腔环境下力学性能稳定，在咀嚼循环条件下的耐疲劳性能良好的优点。

ADDITIVE MANUFACTURING OF RADIOLOGICAL PHANTOMS

Resumen de: US2025152121A1

A formulation usable as a modeling material formulation in additive manufacturing of a three-dimensional object and additive manufacturing methods utilizing same are provided. The formulation comprises one or more curable materials; and a radiopaque material, and features, when hardened, a CT number of at least 100 HU at 70 kV. Objects made by the additive manufacturing method utilizing the formulation are usable as radiological phantoms.

一种可拆卸3D打印义齿的个性化适配卡扣

Resumen de: CN222929860U

本实用新型公开了一种可拆卸3D打印义齿的个性化适配卡扣，包括固定在义齿本体两侧的用于与相邻牙齿卡设安装的卡环，还包括设置在义齿本体上的用于义齿本体安装过程中与相邻牙齿之间适配挤压的适配挤压组件。本实用新型的一种可拆卸3D打印义齿的个性化适配卡扣，义齿在安装的过程中，通过传动，使两组挤压板的一端分别与义齿本体两侧相邻的牙齿相抵，通过相抵作用，对安装后的义齿本体进行自动的适配挤压，且在挤压适配的过程中，推动弹簧的弹力作用，使两组挤压板保持与相邻两组牙齿相抵，避免因使用者口腔的变化造成安装后义齿本体与相邻的牙齿之间产生间隙，便于义齿本体以更加稳定的卡扣方式安装固定。

基于数字化可视化颌位重建技术的矫治器制作方法

Resumen de: CN120078532A

本发明涉及骨性Ⅲ类上颌发育不足的矫治器技术领域，尤其涉及一种基于数字化可视化颌位重建技术的矫治器制作方法，所述矫治器包括基底和颌垫，矫治器的制作包括以下步骤：S1：获取患者相关数据及第一次口扫数据，确定矫治器方案；S2：获取患者的静态咬合状态，确定初步的咬合目标位置，并获得第二次口扫数据；S3：将所述第一次口扫数据和所述第二次口扫数据分别导入至设计软件中，生成数字化模型；S4：通过数字化颌架确定最终颌位；S5：设计基底模型，并3D打印；S6：设计颌垫模型，并3D打印；本方法制作的矫治器组织面能完美匹配患者的牙齿外形，咬合记录目标位置更加符合人体生物学基础，设计更为精确，并可有效防止矫治器脱落。

促进骨质疏松性骨缺损修复的人工骨及其制备方法

Nº publicación: CN120078956A 03/06/2025

Solicitante:

吉林大学

Resumen de: CN120078956A

促进骨质疏松性骨缺损修复的人工骨及其制备方法，属于生物医学材料技术领域。本发明的人工骨由89.65wt%‑89.85wt%的聚乳酸‑羟基乙酸共聚物、9.85wt%‑10.15wt%的纳米羟基磷灰石以及0.1wt%‑0.5wt%的唑来膦酸复合而成。该人工骨中，纳米羟基磷灰石和唑来膦酸在聚乳酸‑羟基乙酸共聚物中均匀分散，结合人工骨表面的多孔结构，有利于成骨细胞在表面的附着，有利于新生骨组织的长入；唑来膦酸的膦酸根能够与纳米羟基磷灰石螯合生成稳定的化学键，将其引入到聚乳酸‑羟基乙酸共聚物中，可以实现唑来膦酸的有效负载，唑来膦酸的有效负载能够抑制破骨细胞过度活化导致的骨吸收增多，修复骨质疏松性骨缺损。