Alerta

用于脊髓损伤修复的神经网络化复合凝胶材料及其制备方法

Resumen de: CN119564929A

本发明公开了一种用于脊髓损伤修复的神经网络化复合凝胶材料及其制备方法。包括如下：1)制备壳层混合微球溶液、芯层基体溶液、芯层网络溶液；2)以芯层基体溶液为基体印材，以芯层网络溶液为分布在基体内网络结构的印材，按照所需图纸进行3D打印并原位UV固化得到在基体中分布有供神经分化预网络结构的复合凝胶；再以所述复合凝胶作为芯层结构，并在其表面打印壳层混合微球溶液并固化后形成壳层结构；3)将2)所得材料在37℃进行成神经培养后得到用于脊髓损伤修复的神经网络化复合凝胶材料，培养时，芯层结构内明胶热致牺牲形成孔道网络。上述凝胶内部设置有神经网络结构，并且可以抑制神经炎症，为神经损伤修复提供全新策略。

用于生产透明正畸附件的可固化组合物

Resumen de: WO2024018305A1

The invention relates to a curable composition comprising a (meth)acrylate not comprising an urethane moiety, an urethane (meth)acrylate, photo-initiator, discrete filler particles having an average particle size in the range of 10 to 40 nm, having been surface treated with a silane surface treating agent selected from a silane surface treating agent comprising a (meth)acrylate moiety, a silane surface treating agent not comprising a (meth)acrylate moiety, and a mixture of both, and the discrete filler particles being present in an amount of 20 wt.% or more, the curable composition further comprising additives, the curable composition not comprising the following components alone or in combination: aggregates of nano-sized particles, agglomerates of nano-sized particles, fumed silica, each in an amount of 2 wt.% or more, wt.% with respect to the curable composition.

一种短期镁合金节育环及制备方法

Resumen de: CN119571159A

本发明公开了一种短期镁合金节育环及制备方法，属于医用合金材料技术领域，该短期镁合金节育环，按照质量百分数计，其元素组成包括：30‑48％Zn；0.5‑3.0％Ca；余量为Mg；并将所述原料依次进行熔炼、浇铸、二次挤压和3D打印，制备得到所述短期镁合金节育环。根据本发明制备方法得到的节育环，在无需外加其他增强辅助成分的条件下，适用于3D触变成型打印，使得其尺寸可控，并适配女性个体子宫，避免了因尺寸不匹配导致的不适、疼痛或移位等问题。

一种细胞微球诱导的仿生骨膜及其制备方法

Resumen de: CN119564928A

本发明提供了一种细胞微球诱导的仿生骨膜及其制备方法，属于仿生骨膜技术领域，本发明首先制备的PDA‑PCL支架，然后将经3D培养板得到的细胞微球负载在所述支架上，经细胞培养，所述细胞微球中PDSCs细胞从最初的细胞聚集物中分散出来，迅速增殖形成一层致密的细胞功能膜，制备得到细胞微球诱导的仿生骨膜；所述仿生骨膜能提供高密度的干细胞，并且能持续分泌对成骨分化和血管生成所必需的生物活性因子，从而使所述仿生骨膜具有优异的促成骨、成血管功能。本发明提供的方法创建一个模拟自然骨环境的仿生骨膜，提出了一种新的骨缺损修复策略：通过在PDA‑PCL支架内扩展PDSC细胞微球生成的仿生骨膜，为推进骨再生治疗提供了一个很有前途的途径。

一种聚醚醚酮基复合材料、骨科植入物及制备方法

Resumen de: CN119564940A

本发明属于骨科植入物材料领域，具体公开了一种聚醚醚酮基复合材料、骨科植入物及制备方法，本申请提供了基于二次挤压成型并配合多个温度区间制备而成的聚醚醚酮基复合材料及其制备方法，还公开了基于此材料制备而成的骨科植入物及制备方法。本申请所提供的聚醚醚酮基复合材料具有优良的物理性能和生物相容性，基于本申请所提供的聚醚醚酮基复合材料制得的骨科植入物不仅具备更强的拉伸强度、弯曲强度，还具备更加优异的生物相容性。

固体剂型生产

Resumen de: JP2024116241A

To provide methods of preparing a solid dosage form, particularly a pharmaceutical formulation, using extrusion and 3D printing; the solid dosage form itself; compositions used to make items; uses of the solid dosage form; and containers used in the preparation thereof.SOLUTION: A method of preparing an extruded item comprises: i. providing an extrudable composition comprising an extrudable carrier; and ii. extruding the extrudable composition into a desired form optionally together with one or more supplementary elements. Preferably, the extrudable composition is extruded via 3D printing.SELECTED DRAWING: None

一种GO膜增强的含血管化网络复合人工凝胶骨膜材料及其制备方法

Resumen de: CN119564923A

本发明公开了一种GO膜增强的含血管化网络复合人工凝胶骨膜材料及其制备方法。包括：1)采用循环刮涂‑烘干法制备多层GO薄膜；2)将GO薄膜置于凸起阵列模具中浇筑HAMA溶液进行UV固化，得到GO薄膜复合凝胶基底层；3)制备含多巴胺包覆的负载促成血管生长因子介孔羟基磷灰石的HAMA溶液；4)使用促成血管分化培养基作为溶剂配制明胶/HAMA混合溶液，并添加骨髓间充质干细胞；5)按照图纸在GO薄膜复合凝胶基底层非平整面3D打印步骤3)和4)中溶液并UV固化，37℃体外成血管培养得到含血管化网络复合人工凝胶骨膜。上述骨膜材料原位打印有血管化网络，并复合有增强和促成骨功能的GO薄膜，实现了对骨膜材料的创新。

BIOPRINTABLE HYDROGEL AND BIOINK

Resumen de: WO2025049706A1

Bioprintable hydrogels, methods of synthesizing, and methods of use thereof are provided.

3D PRINTING OF BIOLOGICS

Resumen de: WO2025049748A2

The present disclosure provides pharmaceutical compositions and methods of preparing pharmaceutical compositions containing an amino acid-based biologic through the use of 3D printing. These pharmaceutical compositions may be used in the treatment of a disease or disorder.

AN EXTENSOR DYNAMIC WRIST-HAND-FINGER SPLINT PRODUCED WITH A 3D PRINTER

Resumen de: WO2025048751A1

The invention relates to an extensor dynamic wrist-hand-finger splint produced with a 3D printer. The splint of the invention is produced with a 3D printer according to the hand size of the patients who have lost their hand functions and aims to enable the patients to regain their hand functions and to perform their daily activities again.

ENZYME AND NANOZYME LOADED MICROPARTICLES

Resumen de: WO2025043269A1

This invention describes microcapsule compositions and methods to encapsulate gas modulating enzymes or nanozymes at unprecedented concentrations and stability, that can be used to regulate the local gas concentrations. Microcapsules can be comprised of gelatin with a polydopamine coating. This system can replace expensive incubators/chambers and is the first system that can create spatiotemporal gradients of gases within a finite volume. The microcapsules have a broad range of applications in tissue culture, bioprinting, in vivo, and industrial uses.

3D-PRINTED EPIDERMAL WEARABLE MICROFLUIDIC ELECTRONIC SKIN FOR MACHINE LEARNING-POWERED MULTIMODAL HEALTH SURVEILLANCE

Resumen de: WO2025049410A1

Systems and methods for a wearable system that monitors various biomarkers with a 3D-printed wearable electronic skin. Specifically, the wearable system is a 3D-printed epidermal wearable microfluidic electronic skin that may be composed of a combination of multidimensional nanomaterials, polymers, and hydrogels. The epidermal wearable microfluidic electronic skin may be integrated with sensors, electrodes, microfluidics, and a processor to collect and analyze molecular biomarkers of biofluid samples on the user's skin, while simultaneously analyzing the user's physiological biomarkers to conduct a health status assessment or gather health monitoring/surveillance metric.

Apparatus for 3D-micro-patterning

Resumen de: US2025078159A1

Recently, we have introduced 3D-micro-patterned pharmaceutical dosage forms for enhancing the efficacy, safety, convenience, and cost-effectiveness of drug therapies. Presented herein is an apparatus for the manufacture of such dosage forms. The apparatus comprises at least a first extruder and at least a second extruder. The first extruder comprises an extruder channel having an exit port with a valve mated to an input port of a second extruder. Said second extruder comprises a translatable piston for extruding plasticized fiber at controlled speed. The apparatus further comprises a stage movable at the controlled speed of the extruded fiber for depositing said fiber to a three dimensional structural framework.

METHOD OF MANUFACTURING A TIBIAL IMPLANT

Resumen de: US2025073041A1

A method for removing a stem portion of an orthopedic implant from a bone comprises exposing an implanted orthopedic implant having a body portion, a stem portion interconnected to the body and a porous metal section forming an interconnection between the body and the stem portion. A cutting tool is mounted on a holder connected to an exposed surface of the orthopedic implant. The porous section is aligned with the cutting tool mounted on the holder. The entire porous section is cut by moving the cutting tool therethrough in a direction transverse to the stem portion axis. The implant body portion is then removed and then the stem portion is removed from the bone. The cutting tool may be a saw or chisel which may be mounted on a guide fixed to the body portion.

MODULAR ACOUSTIC SENSOR ASSEMBLIES

Resumen de: US2025072867A1

A modular acoustic sensor assembly and method of forming the same is disclosed comprising: a two-dimensional acoustic sensor array; an electrically conducting and acoustically attenuating interposer; an assembly connection layer; and a first routing subassembly, wherein at least one electrical routing plane of the interposer is substantially parallel to a principal electrical routing plane of the routing substrate.

SELF CONTAINED CT SCINTILLATORS WITHIN A 3-D PRINTED COLLIMATOR FIELD

Resumen de: US2025072843A1

Post-patient collimators and methods of manufacturing post-patient collimators are provided. An example method includes additively manufacturing a collimator array having a plurality of tapered cavities, positioning a plurality of scintillator pixels within the tapered cavities of the collimator array, and hardening the pixels within the tapered cavities. An example post-patient collimator includes a collimator array including a plurality of cavities, wherein each of the plurality of cavities includes tapered walls, a scintillator including a plurality of pixels, each of the plurality of pixels positioned with one of the plurality of cavities of the collimator, and a reflector positioned on a top of each of the plurality of pixels.

COLLAPSIBLE INNER FLOW CONTROL COMPONENT FOR SIDE-DELIVERABLE TRANSCATHETER HEART VALVE PROSTHESIS

Resumen de: US2025073025A1

A side-deliverable prosthetic heart valve includes an outer frame and a flow control component. The outer frame defines a central channel that extends along a central axis. The flow control component is disposed within the central channel and coupled to the outer frame. The flow control component has a set of leaflets mounted within an inner frame. The prosthetic valve is configured to be folded along a longitudinal axis and compressed along the central axis to place the prosthetic valve in a compressed configuration for delivery via a delivery catheter. The longitudinal axis is substantially parallel to a lengthwise axis of the delivery catheter when disposed therein. The prosthetic valve transitions to an expanded configuration when released from the delivery catheter. The flow control component elastically deforms from a substantially cylindrical configuration to a substantially flattened configuration when the prosthetic valve is placed in the compressed configuration.

FORMULATIONS COMPRISING A THERAPEUTIC PROTEIN AND AT LEAST ONE STABILIZER

Resumen de: US2025073179A1

The invention relates to the field of pharmaceutical compositions comprising proteins as therapeutic active ingredient. More particularly it is directed to di-block or multi-block copolymers used as excipients, and in particular as stabilizer, in protein-containing dried compositions, filaments obtained from these dried compositions, implantable drug delivery device formed from these filaments and to methods of producing such compositions, filaments and devices.

AN ARTIFICIAL INTELLIGENCE ENABLED WEARABLE ECG SKIN PATCH TO DETECT SUDDEN CARDIAC ARREST

Resumen de: AU2023336796A1

There is described an artificial intelligence wearable ECG skin patch (400) to detect sudden cardiac arrest. The wearable ECG monitoring patch (400) with AI based predictive analytics and remote based cardiac monitoring (615) system that can detect cardiac arrhythmias automatically in real-time and make a diagnosis with AI models trained with acquired data. The wearable skin has a biocompatible polymer patch (400) which captures the electrical signal through a flexible printed electronic technology based conducting ink and a substrate. The microcontroller controls (201), store and transmit the data packets. The IoT connected signal transmission is capable of recording and transferring the data packets through wireless communication. The AI engine is capable of analysing, evaluating, testing and providing the data packets of sudden cardiac arrest through a peak detector algorithm. The ECG skin patch (400) to detect and measure the sudden cardiac arrest with the R-R interval time series to obtain heart rate variability.

PROCESS TO OBTAIN THREE-DIMENSIONAL BIODRESSING, THREE- DIMENSIONAL BIODRESSING OBTAINED AND ITS USE

Resumen de: US2025073371A1

The present invention refers to a process to obtain a three-dimensional (3D) biodressing comprising the steps of (a) isolating and culturing mesenchymal cells with human AB serum; (B) performing three-dimensional (3D) bioprinting using a biomaterial such as sodium alginate and cells obtained in step “a”; (c) putting at rest the 3D biodressing obtained after bioprinting; (d) covering the 3D biodressing with a 100 mM calcium chloride solution; (e) washing the 3D biodressing; (f) adding Dulbecco's Modified Eagle Medium (DMEM); and (g) keeping the biodressing in an incubator for up to 15 days. Additionally, the present invention refers to the 3D biodressing obtained comprising, preferably 4% sodium alginate and mesenchymal cells from the umbilical cord (MCUs), which has healing, anti-inflammatory, and analgesic properties. Furthermore, the present invention relates the 3D biodressing to treat patients with chronic wounds and severe burns.

Differentiation of Pluripotent Stem Cells to Form Renal Organoids

Resumen de: US2025075188A1

A method is provided for producing renal organoids comprising nephrons, ureteric bud and vasculature and/or progenitors of these. In one embodiment, the methods includes contacting intermediate mesoderm cells with: fibroblast growth factor 9 and/or fibroblast growth factor 20 and/or fibroblast growth factor 2 and optionally, one or more selected from the group consisting of: bone morphogenic protein 7; heparin; a Wnt agonist; retinoic acid; and an RA antagonist under conditions that promote formation of vascularized renal organoids. Another embodiment includes producing mesoderm cells by sequentially contacting pluripotent stem cells with a Wnt agonist and fibroblast growth factor 9 and/or fibroblast growth factor 20 and/or fibroblast growth factor 2, followed by a relatively short re-exposure to the Wnt agonist. The renal organoids may have end uses such as for kidney repair and regeneration, bioprinting of kidneys or functional components thereof, renal cell arrays and screening compounds for nephrotoxicity.

DEVICE AND METHOD FOR MARKING EDIBLE OBJECT

Resumen de: EP4403363A2

An edible-body marking device (1) has a carrier device (20) that carries an edible body, a detection part (210) that detects the edible body, and a laser processing part (220) that forms a marking pattern on the edible body by using laser light. The carrier device sequentially carries the edible body to the detection part (210) and the laser processing part (220). The detection part images (210) the edible body to acquire orientation information regarding an orientation of the edible body, and the laser processing part (220) has a memory part that stores in advance multiple pieces of marking procedure information regarding formation procedures of the marking pattern in association with their respectively different pieces of the orientation information, and forms the marking pattern on the edible body according to the marking procedure information extracted from the memory part based on the orientation information acquired by the detection part (210).

HOLLOW EMBOLIC MICROSPHERE, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSITION AND USE THEREOF

Resumen de: EP4516327A1

A hollow embolic microsphere, a preparation method therefor, and a pharmaceutical composition and use thereof, wherein: the hollow embolic microsphere is a microsphere prepared by using a polymer material and having a unique shape and structure, and is suitable for transcatheter arterial embolization. The hollow embolic microsphere of the present disclosure can enter channels having different sizes, and has good embolization effects on various target positions. The hollow microsphere is internally porous and has drug loading abilities, and drug release when loading drug can be easily controlled and the treatment effect is good. No emulsifier or surfactant is needed in the preparation of the hollow microsphere, reaction conditions are mild, and the process is simple. The obtained microsphere has a uniform shape and a controllable size, and is capable of controlling the embolization time. Various drugs including protein heat-sensitive drugs can be loaded, and the drug encapsulation efficiency can reach more than 70%.

METHOD FOR PRODUCING AN IMPLANT AND IMPLANT

Resumen de: EP4516428A1

Die Erfindung bezieht sich auf ein Verfahren zur Herstellung eines Implantats (1), wobei das Implantat wenigstens zwei miteinander verbundene Bauteilabschnitte (1a, 1b, 1c) aufweist, die wenigstens in einem Bereich (1d), in dem sie aneinander angrenzen, durch ein additives Fertigungsverfahren in Form eines Pulverbett-Verbindungsprozesses hergestellt werden, wobei ein erster Bauteilabschnitt (1a) aus einem ersten Material und ein zweiter Bauteilabschnitt (1b) aus einem zweiten Material hergestellt wird, wobei das erste und das zweite Material sich durch das Maß ihrer Bio-Kompatibilität unterscheiden. Das additive Herstellungsverfahren ermöglicht dabei eine sehr freie Gestaltung der verschiedenen Bauteilabschnitte des Implantats.

TRANSCATHETER DELIVERABLE PROSTHETIC HEART VALVES

Nº publicación: EP4516266A2 05/03/2025

Solicitante:

VDYNE INC [US]
Vdyne, Inc

Resumen de: EP4516266A2

A prosthetic valve includes a frame and a flow control component. The frame has an aperture extending through the frame about a central axis. The flow control component is mounted within the aperture and is configured to permit blood flow in a first direction approximately parallel to the vertical axis from an inflow end to an outflow end of the flow control component and to block blood flow in a second direction, opposite the first direction. The frame has an expanded configuration with a first height along the central axis, a first lateral width along a lateral axis perpendicular to the central axis, and a first longitudinal length along a longitudinal axis perpendicular to the central axis and the lateral axis. The frame has a compressed configuration with a second height less than the first height and a second lateral width less than the first lateral width.