Alerta

全口义齿及全流程数字化的全口义齿制作方法

Resumen de: CN120678548A

本发明公开全口义齿及全流程数字化的全口义齿制作方法。本发明以光学印模替代传统印模，电子运动面弓+下颌运动轨迹描记替代机械面弓+哥特式弓描记，结合语音法显示的下颌轨迹特征，替代传统的颌位记录，技术敏感性更低，颌位关系记录更精准，在口扫后过软件预排牙和电子面弓直接生成咬合方案，省去蜡型试戴、传统的颌位记录等中间步骤，且本申请采用数字化制造减少手工操作，三维打印/切削技术直接输出义齿，省去装盒、煮牙、打磨等繁琐工序，制作周期大大缩短，往后二次复制或再制作时间及适应时间大大等缩短，并为全口种植咬合重建颌位提供数字化解决方案，更利于数智数据的开发、整合等。

医用组织包裹物

Resumen de: AU2023370241A1

The invention relates to the field of medical tissue wraps for internal anatomical structures as well as a use and a method of treating a nerve lesion using such medical tissue wraps. In particular, the invention relates to medical tissue wraps for neural tissue supporting the repair of peripheral nerve lesions by facilitating secure application of the medical tissue wrap. Accordingly, a medical tissue wrap (10) for an internal anatomical structure of a mammal is suggested, wherein the medical tissue wrap (10) is formed by a coiled wall (12) having a circumferential inner end portion (20) and a circumferential outer end portion (22) extending around and overlapping the circumferential inner end portion (20). The wall (12) thereby defines a longitudinal through-hole (16) for accommodating a portion of the anatomical structure. According to one aspect of the invention, the circumferential outer end portion (22) is radially spaced-apart from the circumferential inner end portion (20) by a discontinuous spacing in the circumferential direction. According to a further aspect, the tissue wrap comprises a structural outer surface modification at opposing longitudinal end portions of its wall.

用于3D打印的金属粉末

Resumen de: US2024123495A1

A method of using a metal powder in an additive manufacturing process. The method includes providing the metal powder, and using the metal powder in the additive manufacturing process. The metal powder is a metal which is selected from tantalum and impurities, titanium and impurities, niobium and impurities, an alloy of tantalum, niobium and impurities, an alloy of titanium, niobium and impurities, and an alloy of tantalum, titanium, niobium and impurities. Particles of the metal powder have a dendritic microstructure. Particles of the metal powder have an average aspect ratio ΨA of from 0.7 to 1, where ΨA=XFeret min/XFeret max.

一种仿生甲虫骨架植入物的制备方法

Resumen de: CN120680013A

本发明公开了一种仿生甲虫骨架植入物的制备方法，属于股骨植入领域。本发明创新性地将甲虫鞘翅和角质层的仿生结构特征相结合，通过仿生结构设计的方法有效提升了多孔镍钛合金结构植入体的力学强度和结构稳定性，成功解决了传统股骨金属植入物长期存在的应力屏蔽效应问题，采用选择性激光熔化（SLM）技术制备出的多孔镍钛合金仿生骨架结构，其不仅具有良好的力学适配性，避免了植入后与自然骨组织的排斥脱落反应，还能在室温环境下实现完全的形状记忆恢复功能，在医用骨科植入领域具备良好的应用前景。

一种种植基台的牙冠批量打印装置及方法

Resumen de: CN120680724A

本发明提供了一种种植基台的牙冠批量打印装置及方法包括：利用牙龈形态数据库对患者牙龈采样数据进行深度优化，确定患者的基台排布特征并确定所述患者的基台打印数据，根据所述患者的已提需求和所述基台排布特征创建所述患者的若干种牙冠形态，并构建每一所述牙冠形态对应的牙冠打印数据，根据所述患者的面部数据分别模拟每一所述牙冠打印数据对应的打印效果，根据指令选取目标牙冠打印数据，根据所述基台打印数据和所述目标牙冠打印数据分别打印所述患者的基台和牙冠，根据患者的需求和实际取模结果自动调整打印设备的激光功率和打印预备工作，可以实现牙冠和基台的批量打印或个性化打印，提高了打印的效率，确保了打印成品的质量。

3D FILAMENT FOR 3D PRINTER COMPRISING ACETAMINOPHEN AND IBUPROFEN AND DUAL RELEASE FORMULATION AND METHOD OF PREPARING THE SAME

Resumen de: KR20250138511A

본 발명은 속방출 필라멘트층 내부에 분포된 서방출 과립층을 포함하고, 상기 서방출 과립층은 아세트아미노펜(acetaminophen) 또는 이의 약학적으로 허용가능한 염 및 제1 고분자를 포함하고, 상기 속방출 필라멘트층은 이부프로펜(ibuprofen) 또는 이의 약학적으로 허용가능한 염 및 제2 고분자를 포함하며, 상기 제1 고분자는 상기 제2 고분자 보다 유리전이온도가 높은 것을 특징으로 하는 3D 프린터용 필라멘트, 이를 이용한 이중방출 제형 및 제조방법에 관한 것이다.

ARTIFICIAL PROSTHESIS WITH SURFACE ROUGHNESS

Resumen de: KR20250137767A

별도의 쉘을 포함하지 않는 인공 보형물로서, 생분해성 고분자를 포함하고, 상기 인공 보형물의 외부 표면은 최대 높이 거칠기 값(Rmax)이 3~45μm이고, 상기 인공 보형물의 외부 표면은 10점 평균 거칠기 값(Rz)이 3~45μm인, 인공 보형물이 제공된다.

볼 플런저를 사용하여 모델을 고정하기 위한 기술

Resumen de: MX2025006182A

The present disclosure discusses techniques for securing thermoform models, including a locator plate for receiving and securing individually unique dental models having a polygon cutout, wherein the locator plate has at least one ball plunger (108) positioned within a raised polygon (102), the at least one ball plunger having a cylindrical body, a spring, and a ball extending partially outside the cylindrical body. The present disclosure also includes a system for thermoforming an orthodontic aligner and methods thereof.

バイオプリントされた軟組織補強足場

Resumen de: CN119968177A

The present disclosure encompasses systems, compositions, and methods for use in vivo, including for enhancing soft tissue in an individual. The systems, compositions, and methods may utilize a three-dimensionally printed scaffold comprising at least a polymeric scaffold and an extracellular matrix component, including an extracellular matrix component contained on the scaffold. The polymer scaffold may include specific unit cell structures having a specific design and a pattern of alternating configurations of unit cell structures.

光固化生物墨水、数字光处理3D打印产品及其制备方法和在制备颅骨修复材料中的应用

Resumen de: CN120661738A

本发明提供了光固化生物墨水、数字光处理3D打印产品及其制备方法和在制备颅骨修复材料中的应用，属于生物医药技术领域。本发明提供的材料能够在不同环境条件下持续地释放H₂O₂。尤其是在模拟体内环境中，GHDP水凝胶在较长时间内保持稳定的H₂O₂释放，从而不断激活血管生成相关的信号通路，在颅骨缺损修复过程中，能够通过调控H₂O₂水平，促进新生血管形成和成骨分化，为利用氧化还原信号调控来促进组织再生提供了新的策略与思路。

一种梯度致密度金属植入物增材制造方法

Resumen de: CN120662830A

本发明提供了一种梯度致密度金属植入物增材制造方法，涉及激光选区熔化增材制造技术领域，该方法通过多模态传感器融合与自适应控制算法，实现金属植入物从外层到内层的连续梯度致密度分布，精确模拟骨骼的生物力学特性，从而省去设计多孔结构的步骤；可精确模拟人体骨骼的皮质骨(高致密)与松质骨(多孔)结构，提升植入物的生物力学适配性。

一种光固化3D打印含碳导电多孔材料及其制备方法及应用

Resumen de: CN120665428A

本发明涉及一种光固化3D打印含碳导电多孔材料及其制备方法及应用。该方法基于巯基‑烯点击化学与聚合诱导相分离原理，通过将含巯基低聚物、含烯基低聚物、导电碳材料及致孔剂复配为低粘度墨水，通过对墨水聚合反应动力学和流变性质研究，结合光固化3D打印技术一步成型多尺度多孔结构。所述致孔剂兼具溶剂功能，降低墨水粘度并诱导微观孔隙生成，与宏观模型设计结合，形成多级孔隙网络。所得材料在智能传感、电磁屏蔽及水处理等领域展现出潜在应用价值。

一种基于3D打印的可降解鼻大翼软骨支架及其制备方法

Resumen de: CN120661739A

本发明公开了一种基于3D打印的可降解鼻大翼软骨支架及其制备方法，支架由PLGA以及纳米羟基磷灰石复合基体、载药微球及梯度多孔仿生结构组成，表面覆盖壳聚糖涂层以增强细胞黏附性。通过调控PLGA分子量和羟基磷灰石含量实现降解速率与软骨再生速率匹配。支架内部嵌入载有地塞米松与TGF‑β的微球。制备方法结合熔融沉积3D多喷头协同打印技术与患者CT/MRI数据建模。相较于传统不可降解材料及现有可降解支架，本发明兼具力学适应性、降解可控性、药物功能集成化及临床适配性优势，适用于先天性鼻畸形、外伤性缺损修复及联合自体软骨移植治疗，有效解决了现有材料生物相容性差、降解速率失配及通用性不足等问题。

一种3D打印构建骨肿瘤修复的压电骨支架的制备方法

Resumen de: CN120661733A

本发明公开了一种3D打印构建骨肿瘤修复的压电骨支架的制备方法，属于生物医用材料领域。所述方法通过3D打印构建骨肿瘤治疗修复的压电骨支架材料，具体包括以下步骤：均匀混合固定体积比的钛酸钡(BTO)和羟基磷灰石(HA)，通过光固化树脂，打印具有特定孔隙结构的生胚，随后经过脱脂、烧结、极化和后处理，制得BTO/HA压电复合骨支架。本发明制备得到的压电复合骨支架具有与骨缺损部位高度匹配的精确形状，同时可通过压电效应催化产生活性氧自由基，实现残留骨肿瘤细胞的高效原位灭活，将骨肿瘤治疗(压电抗肿瘤)和骨缺损修复(HA促骨化)两大功能集成于一体，提升治疗修复效果，改善患者的生活质量。

SACROPELVIC FUSION IMPLANT SYSTEM FOR PROVIDING A FOUNDATION FOR SPINOPELVIC FIXATION CONSTRUCTS IN ADULT SPINAL DEFORMITY SURGERY

Resumen de: US2025288424A1

A method of surgically treating a patient suffering from severe pain and disability of the low back and buttock by stabilizing the patient's spinal column to their pelvis with an implant system including surgical tools and an implant designed to prevent movement between the sacrum and the ilium while being able to attach to a spinal fusion rod which connect to pedicle screws implanted in the bones of the spine of the patient in order to offer lasting relief of the patient's symptoms. The system is designed to address complications in adult spinal deformity by optimizing spinopelvic fixation vis-à-vis the unique biomechanics of the SI joint. The sacropelvic system is a surgical solution which provides an additively manufactured implant at the base of the spine employing an S2AI trajectory while utilizing assisting technologies including surgical navigation and intraoperative neurophysiological monitoring.

3D PRINTED STRUCTURALLY SOUND PROSTHETIC SOCKET

Resumen de: US2025288423A1

A method for 3D printing a prosthetic socket from a digital model, including printing a solid wall perimeter of the prosthetic socket with a width achieved in a single pass of a printing nozzle, and forming a plurality of stiffener elements proximate a bottom end of the prosthetic socket, as a function of the printing the solid wall perimeter, is provided. Also provided is a 3D printed prosthetic socket including an upper portion, a lower portion configured to be attached to a prosthetic pylon, and a plurality of stiffener elements radially extending from the lower portion, wherein the upper portion, the lower portion, and the plurality of stiffener elements are printed as a solid wall construction comprised of a printing material deposited using only a single pass of a printing nozzle.

IMPLANT SYSTEM AND METHOD FOR JOINT FUSION

Resumen de: US2025288331A1

Implant systems and methods treatment of a joint include a distal portion, a middle portion, and a proximal portion. The distal portion may include a thread having a first thread minor, a first thread major, and a first pitch. The distal portion also may have a reverse cut, helical fenestration formed through the thread. The middle portion may be devoid of threads and may include a porous outer surface structure to promote bony integration, the porous outer surface structure having a leading end and a trailing end, with the leading end having a diameter larger than the first thread minor. The proximal portion may include a proximal thread having a second thread minor, a second thread major, and a second pitch. The second thread minor may be substantially the same width as the trailing end of the middle portion.

SPRAYED MULTI ADSORBED-DROPLET REPOSING TECHNOLOGY (SMART)

Resumen de: US2025288524A1

Described are techniques, systems, and methods include those employing pneumatic, pressure assisted, extrusion-based 3D printing and emulsion evaporation, emulsion diffusion, nanoprecipitation, desolvation, gelation, spray-based atomization, etc. for fabricating loaded microparticles or nanoparticles that encapsulate an active pharmaceutical ingredient or live cells into a biocompatible polymer or pharmaceutical excipients. The techniques provide for encapsulation of a variety of substances including proteins, plasmid DNA, lipophilic pharmaceutical compositions, hydrophilic pharmaceutical compositions, live cells, and/or cellular components into polymeric microparticles or nanoparticles. The particles loaded with active pharmaceutical ingredients can be used for the treatment of different diseases or conditions. The particles loaded with live cells can be used for disease treatment, but can also be used for securely storing the live cells in a stable condition for transport and later use in inoculating fermentation systems, for example, to generate recombinant proteins.

3D PRINTED COMPOSITES FROM PHASE SEPARATED MATERIALS

Resumen de: US2025289919A1

The present disclosure provides methods, systems, devices, and kits for creating composite materials from a single resin, the composite materials having multiple continuous phases. The disclosure includes a process to three-dimensionally print objects (e.g., orthodontic appliances) with composite properties. In some aspects, the composite properties are formed from a single formulation with components that, when processed, have hard and soft continuous phases. In some aspects, the composite properties are formed by separately processing the hard phase components and the soft phase components. In some aspects, the composite materials and devices are three-dimensionally printed using the processed material.

FUNCTIONALIZED AND CROSSLINKED POLYMERS

Resumen de: US2025289909A1

Polyhydric polymers may be converted to derivatives thereof by reaction with divinyl sulfone to provide vinyl sulfone substituted polymers, where the polymers may additionally be further derivatized, including crosslinked, and the crosslinked and non-crosslinked derivatives may be used in biomedical and other applications.

BIOINK COMPOSITIONS COMPRISING THERMOSENSITIVE MICROPARTICLES AND USE THEREOF

Resumen de: WO2025191563A1

The present invention is directed to a method for 3D printing of cells attached to a cell scaffold by simultaneous printing of a first composition comprising thermoresponsive microparticles and a second composition comprising cells. Further provided a printed 3D object such as an implant, comprising cells attached to the cell scaffold of the invention.

Vorrichtung zur Herstellung von Tabletten

Resumen de: DE102024107712A1

Die Erfindung betrifft eine Vorrichtung (1) zur Herstellung von Tabletten (2), wobei die Vorrichtung (1) eine Vorläufermaterialherstellungseinrichtung (3) und eine additive Fertigungseinrichtung (4) aufweist, wobei die Vorläufermaterialherstellungseinrichtung (3) ausgebildet ist, um über einen Arzneistoff (5) verfügende Granulatpartikel (6) mit einem ein thermoplastisches Material (7) aufweisenden Beschichtungsmittel (8) zu beschichten, um Vorläufermaterialpartikel (9) zu erzeugen, und wobei die additive Fertigungseinrichtung (4) ausgebildet ist, um aus einem über eine Vielzahl von Vorläufermaterialpartikeln (9) verfügenden pulverförmigen Vorläufermaterial (10) durch selektives Lasersintern Tabletten (2) herzustellen.

Verfahren zur Herstellung von Tabletten

Resumen de: DE102024107710A1

Die Erfindung betrifft ein Verfahren zur Herstellung von Tabletten (2), wobei dass das Verfahren einen Beschichtungsschritt und einen auf den Beschichtungsschritt folgenden additiven Fertigungsschritt aufweist, wobei im Beschichtungsschritt über einen Arzneistoff (5) verfügende Granulatpartikel (6) mit einem ein thermoplastisches Material (7) aufweisenden Beschichtungsmittel (8) beschichtet werden, um Vorläufermaterialpartikel (9) zu erzeugen und im additiven Fertigungsschritt ein selektives Lasersintern eines über eine Vielzahl von Vorläufermaterialpartikeln (9) verfügenden pulverförmigen Vorläufermaterials (10) zu Tabletten (2) durchgeführt wird.

THREE-DIMENSIONAL PRINTING COMPOSITION COMPRISING METHACRYLATED CHITOSAN

Resumen de: WO2025193112A1

The invention relates to a three-dimensional printing composition comprising a dECM hydrogel-based biomaterial, a hydrogel made of methacrylated PBS biopolymer derivatives with a radical polymerisation photoinitiator, a methacrylated chitosan solution in 1% acetic acid, neutralised to a final concentration of 3.1 mg/ml in the biomaterial, and/or a chitosan solution in 2% acetic acid, neutralised to a final concentration of 1.4 mg/ml in the biomaterial.

CHAMBER WITH FLOW SYSTEM FOR BIOPRINTING AND CULTURING TISSUES MODELS

Nº publicación: WO2025193110A1 18/09/2025

Solicitante:

POLBIONICA SPOLKA AKCYJNA [PL]
POLBIONICA SPOLKA AKCYJNA

Resumen de: WO2025193110A1

The utility model relates to a chamber with a flow system for the bioprinting and culturing tissue models, containing: a chamber body (1 ) with a central opening obscured by a bottom glass (2), covered from the top by a cover (3) provided with a central opening obscured by a upper glass (5), whereby a silicone circular seal (4) is provided between the chamber body (1) and the chamber cover (3), wherein the chamber body (1) at its two opposite ends is provided with connectors (8) with connecting channels (10) providing a fluid connection to the working volume of the chamber defined by the inner walls of the chamber body (1 ) and the cover (3), the circular seal (4) and the inner surfaces of the bottom glass (2) and the upper glass (5) facing each other, where the flow system is formed by the connectors (8) with the connecting channels (10) and the working volume of the chamber contained between them; and an outer casing of the chamber comprising a bottom frame (6) and a top frame (7), wherein the chamber body (1) and the chamber cover (3), together with the elements contained between them, are enclosed between the bottom frame (6) and the top frame (7) of the outer casing, which are detachably connected to each other.