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椎间融合器用近红外3D打印硅橡胶复合材料及其制备方法

Resumen de: CN120393108A

本发明公开了椎间融合器用近红外3D打印硅橡胶复合材料及其制备方法，将YbCl3·6H2O与TmCl3·6H2O/ErCl3·6H2O/PrCl3·6H2O按摩尔比(Tm:Er＝1:0.2～0.5或Tm:Er:Pr＝1:0.2～0.5:0.1～0.3)溶于水，与EDTA‑2Na、NaF、AgNO3反应制得NaYbF4:M/Ag；再经SiO2包覆和CTAB/硅烷改性获得硅烷改性NaYbF4:M@SiO2复合粒子；再将其与热/光固化硅橡胶单体、引发剂及羟基磷灰石混合制得近红外光‑热协同固化硅橡胶墨水。该材料可实现高精度3D打印，兼具良好生物相容性和力学性能，适用于椎间融合器医疗硅橡胶制品的制备。

基于柔性糖牺牲载体的可注射中空支架及其制备方法

Resumen de: CN120393118A

本发明涉及一种基于柔性糖牺牲载体的可注射中空支架及其制备方法，将蔗糖、果糖、葡聚糖、葡萄糖混合溶解到蒸馏水中，高温持续搅拌得到粘稠溶液，高温交联得到糖打印材料；利用糖打印材料在平面内打印柔性糖网平面基材，为软质柔性可形变状态；对柔性糖网平面基材进行塑形，得到柔性糖牺牲载体，将PCL涂层液多层涂覆到柔性糖牺牲载体，得到双层支架；置于蒸馏水中溶解柔性糖牺牲载体，得到可注射中空支架。本发明通过精确控制柔性糖牺牲载体中各组分的比例，令其性状可一段时间内维持软质柔性可形变状态，仅需要在二维平面内打印出基材，然后塑型处理，实现对特定器官形态的模拟，提高了复杂器官重建的准确性和可行性。

一种用于皮肤及毛囊再生的预制化生物3D打印人工皮肤制备方法

Resumen de: CN120393113A

本发明提供一种用于皮肤及毛囊再生的预制化生物3D打印人工皮肤制备方法，主要包含GelMA、HAMA和皮肤干细胞。生物3D打印人工皮肤的制备方法是首先配置每毫升含50毫克GelMA和5毫克HAMA的水凝胶溶液，再加入107‑108个皮肤干细胞，真皮干细胞和表皮干细胞比例为1:2。最后，将细胞与水凝胶混合也转入注射器冷藏3分钟后移入生物3D打印机中，按预设打印参数制备不同模型的人工皮肤。本发明所优化的水凝胶材料具有优良的可打印性，较低的溶解度和溶胀率以及稳定的力学性能。本发明采用的水凝胶材料能够与皮肤干细胞配合促进皮肤干细胞的干性提高，更利于皮肤的修复与毛囊的再生。本发明制备的生物3D打印人工皮肤可立即或体外培养后用于伤口中促进皮肤及毛囊。

一种3D打印微针及其制备方法和其应用

Resumen de: CN120392633A

本发明涉及一种3D打印抗菌微针，所述微针为由载药针尖层、针体层、载药储库层和基底层制成的多层仿生蘑菇状结构，其中，载药针尖层：针体层：载药储库层：基底层的体积比为1:1:20‑50:20‑50；载药针尖层采用可溶性聚乙烯吡咯烷酮负载纳米复合体后制得；针体层由甲基丙烯酰化聚赖氨酸和甲基丙烯酰化透明质酸钠浓缩后光共交联后制得；载药储库层由采用可溶性聚乙烯吡咯烷酮负载纳米复合体后制得；基底层由不可降解的聚乙二醇二丙烯酸酯光交联后制成。本发明采用3D打印联合聚二甲基硅氧烷翻模法一体化制备微针，所述微针具有优异的机械性能和穿刺性能，利于在创伤部位实现自主给药，实现药物的精准释放、高效摄取及“组织渗透‑细菌靶向‑基因沉默”的级联效应，显著缩短创面愈合时间，显著提高抗菌药物的靶向递送效率、生物利用度和安全有效性，攻克核酸药物难以用于抗创面感染的问题。

用于制造正畸器具的包含可聚合反应性稀释剂的可固化组合物

Resumen de: US2024191006A1

The present disclosure provides curable compositions comprising one or more of photo-polymerizable monomers as reactive diluents, as well as polymeric materials formed from the curable compositions. Further provided herein are methods of producing the compositions and using the same for the fabrication of medical devices, such as orthodontic appliances.

3D打印多孔金属-陶瓷组配式复合植入体及其制备方法和应用

Resumen de: CN120392380A

本发明涉及一种3D打印多孔金属‑陶瓷组配式复合植入体及其制备方法和应用。3D打印多孔金属‑陶瓷组配式复合植入体:包括由3D打印一体式多孔金属模块和3D打印一体式多孔陶瓷模块复合在一起的多孔金属‑陶瓷植入体本体、包置于多孔金属‑陶瓷植入体本体外周的网状金属保护体一起形成的能够与缺损部位骨组织的外形和结合面精准匹配的组配式复合植入体。发明所述复合植入体，具有成骨环境调控功能化，能达到即时恢复缺损骨组织的运动功能，改善骨缺损部位组织微环境，加速新骨再生并引导新骨向多孔金属植入物内部生长，实现骨/金属植入物界面的快速骨整合，以及陶瓷降解后3D打印多孔金属植入物/自体骨融合式修复的远期治疗效果。

一种体外调节的单向滑动生长棒

Resumen de: CN120392262A

本发明涉及骨科医疗器械技术领域，具体涉及一种体外调节的单向滑动生长棒，包括：近端套筒、远端套筒、卡扣部件、弹簧驱动部件以及可拆卸预弯棒，远端套筒的内筒壁开设有直线滑槽，近端套筒外壁形成直线滑条，近端套筒的一部分套接在远端套筒的内筒内部，远端套筒的内筒设有所述弹簧驱动部件，远端套筒的外壁安装有卡扣部件，滑动生长棒两端分别连接有可拆卸预弯棒，卡扣部件内包括卡扣外壳、限位部件和单向滑动部件；本发明能够提高生长棒的性能。

一种用于口腔修复材料的3D打印辅助设计系统

Resumen de: CN120392358A

本发明涉及三维模型设计技术领域，且公开了一种用于口腔修复材料的3D打印辅助设计系统，包括数据采集模块、初始模型设计模块、设计优化模块以及结果输出模块；通过设有初始模型设计模块与设计优化模块，有利于基于构建个体的口腔模型，从牙型数据库中选取与个体匹配度最高的修复体模型作为初始模型，基于改进后的优化算法获取最优调整参数，根据最优调整参数对初始模型的修复体设计参数进行调整优化，获取优化后的修复体模型；通过精确的数据对修复材料进行智能优化设计，结合人体的牙型数据库与患者的个体数据，进行个性化的修复材料设计的优化，进而同时保证牙齿外形的美观性与实用性。

含图案的液体及其制造方法

Resumen de: AU2023419073A1

The purpose of the present invention is to provide: a liquid with a pattern, said liquid including a pattern that can produce, in a liquid matrix, a sensation such as a color, a flavor, a texture, or a tactile sensation, said pattern having good stability; and a method for producing a liquid with a pattern which makes it possible to stably form a pattern in a liquid matrix. The present invention relates to, for example, a liquid with a pattern, said liquid including, in a liquid matrix, a pattern formed by microparticles and/or a pigment, wherein the liquid matrix is pseudoplastic fluid and is accommodated in a container.

用于制造金属嵌入式医疗植入物和装置的三维打印方法

Resumen de: WO2024093647A1

Three-dimensional (3D) printing methods for making metal-embedded medical implants and devices are provided. The newly developed 3D printing technology and surface modification method will contribute to the wider application of 3D-printed patient-specific products in many medical fields showing excellent clinical safety.

一种3D打印肝癌切除手术导板的制造方法

Resumen de: CN120392288A

本发明涉及医学领域，且公开了一种3D打印肝癌切除手术导板的制造方法，包括以下步骤：CT数据采集：进行肝脏增强扫描，获取多期DICOM格式数据；应用3D可视化软件，以门静脉4级分支流域为基础，规划肝脏切除范围并确定手术切面；应用3‑matic Medical等工程软件，基于手术切面设计肝脏表面及实质内手术导板；使用3D打印机将数字手术导板打印为实物模型，用于手术定位与导航。传统的肝癌手术规划建立在标准的肝脏分段方法之上，缺乏个性化。目前主要应用肝蒂阻断法及染料注射法进行手术路径导航，存在操作复杂、成功率低、重复性差等问题。本发明为一种3D打印肝癌切除手术导板的制造方法，通过3D数字技术实现手术科学规划与精确导航。通过本技术方法提高手术的根治性与安全性，增进肝癌治疗效果。

一种牙模3D打印控制系统

Resumen de: CN120396331A

本发明提供了一种牙模3D打印控制系统，包括：LCD屏幕、用于发射紫外光的UV光源、用于附着已固化模型的成型平台、盛放液态陶瓷填充光敏树脂的料槽、墨盒、带动成型平台与墨盒移动的Z轴和X轴电机、丝杠以及传感器。所述墨盒外部配备磁铁结构，可紧密吸附在料槽的钢板上；磁铁外围集成刮刀组件，使得墨盒在运动过程中能够同时对浆料进行均匀刮平；墨盒顶部配备墨盒盖。本系统不仅优化了料槽设计，还配备了自动供料墨盒，以在打印过程中动态补充浆料，同时利用墨盒中的刮刀组件确保浆料均匀分布，优化固化质量。这种设计有效避免了传统光固化3D打印机因浆料供给不足或分布不均而导致的打印缺陷。

一种载姜黄素3D生物打印墨水及其制备方法与应用

Resumen de: CN120393112A

本发明公开了一种载姜黄素3D生物打印墨水及其制备方法与应用，属于3D生物打印材料技术领域。该制备方法具体包括以下步骤：(1)包载物的制备；(2)姜黄素纳米粒子溶液的制备；(3)载姜黄素3D生物打印墨水的制备。本发明采用物理混合的方法将姜黄素纳米粒子溶液和高分子粉末混合，由此制得的载姜黄素3D生物打印墨水具有显著的抗炎活性和较好的促进伤口愈合效果，同时具有较好的可打印性和ROS响应释放特性，可用于载药医疗器械，对提高姜黄素的给药精确性具有重要意义。而且，本发明制备方法操作简单，效果显著，应用范围广，能拓宽载姜黄素3D生物打印墨水的应用范围，具有良好的应用前景。

CERAMIC DEVICES AND METHODS OF MAKING AND USING THE SAME

Resumen de: US2025243128A1

The present invention relates to methods for preparing ceramic devices having a surface that has been activated to enhance properties including strength, porosity, and bioactivity. Activation may include forming a gel layer on the surface of a ceramic device using an alkali solution and modifying the surface using a modifying material. The invention further relates to ceramic devices prepared by the methods and methods of using the devices.

MINIMALLY INVASIVE AND ENDOSCOPIC IN-VIVO BIOPRINTING SYSTEMS AND METHODS

Resumen de: US2025242171A1

A system may include a donor supply sub-system configured to supply donor material to a donor substrate. The system may include a material transfer sub-system comprising a laser configured to illuminate the donor substrate via a transfer beam. The system may include an instrument head of a medical instrument configured to house the donor substrate, wherein upon an illumination of the donor substrate, the donor material is transferred to receiver material in vivo.

NOVEL POLYMER

Resumen de: US2025242078A1

The present invention relates to a functionalised polymer, methods of preparing the functionalised polymer, and compositions comprising the functionalised polymer. The present invention also relates to methods of using the functionalised polymer including for forming a polymer composition comprising cells from a tissue sample and for cell therapy.

METHOD AND SYSTEM FOR MERGING BIO-ELECTROSPRAYING, CELL ELECTROSPINNING MERGED WITH 3D MULTIMATERIAL MICROFLUIDIC BIOPRINTING FABRICATE HUMAN TISSUES FOR DRUG DISCOVERY APPLICATIONS

Resumen de: US2025243452A1

The present invention provides a method and system for fabricating complex human tissues by integrating bio-electrospraying, cell electrospinning merged with 3D multi material microfluidic bioprinting, and future additions of magnetic and acoustic levitation technologies. The fabricated tissues serve as an alternative to animal testing in drug discovery processes, aiding in the prediction of human physiological responses to various drug compounds.

3D-PRINTED, WELL PLATE-INTEGRATED PIEZOELECTRIC CANTILEVER SENSORS FOR CELL CULTURE MONITORING

Resumen de: US2025243447A1

A hybrid microextrusion pick-and-place 3D printing process enables fabrication of 3D-printed well plate-integrated piezoelectric cantilever sensors for monitoring properties and composition of tissue culture models. 3D-printed piezoelectric cantilever sensors exhibit multiple resonant modes across the 1-150 kHz frequency range. The ability to control cantilever frequency response (i.e., mode locations and types) was demonstrated by variation in the 3D-printed anchor geometry through corresponding changes in tool path and microextrusion process parameters. 3D-printed piezoelectric cantilever sensors facilitated in situ monitoring of cell culture media density and viscosity. This work presents an advance in the fabrication of cantilever sensors through the use of hybrid 3D-printing and pick-and-place processes that improves sensor reproducibility and enables novel control over anchoring of piezoelectric components and sensor integration with both 2D and 3D cell culture models, particularly 3D-bioprinted tissue constructs and microphysiological systems.

METHODS OF PRODUCING MULTI-LAYERED TUBULAR TISSUE CONSTRUCTS

Resumen de: US2025243465A1

Described are methods for producing multi-layered tubular tissue structures, tissue structures produced by the methods, and their use.

3D BIOPRINTED HYDROGEL MICROFLUIDIC SYSTEMS AND PERFUSION BIOREACTORS FOR ENGINEERING VASCULARIZED TISSUE CONSTRUCTS

Resumen de: WO2025160474A1

3D bioprinted hydrogel microfluidic systems and perfusion bioreactors for engineering vascularized tissue constructs are provided. An example of an internally perfusable scaffold comprises an exterior surface, a body, a first port, and an interior wall. The first port comprises a first coupling feature configured to engage a fitting and form a fluid tight seal therewith. The first interior wall defines a fluid cavity extending into the body from the first port. The scaffold comprises a hydrogel.

SYSTEM AND METHOD FOR CERAMIC INKJET MESH PRINTING

Resumen de: US2025241735A1

Disclosed are systems and methods for a computerized framework for automated ceramic inkjet printing in dental restoration manufacturing. The disclosed ceramic inkjet mesh printing for dental restorations combines precision digital control with ceramic materials to create highly accurate and aesthetically pleasing dental prosthetics. The disclosed mechanisms utilize specialized printheads designed to deposit precise amounts of ceramic materials onto dental substrates, enabling the creation of detailed color gradients and natural-looking surfaces that closely mimic natural teeth.

SYSTEM AND METHOD FOR GLAZING DENTAL RESTORATIONS WITH CERAMIC INK VIA INKJET PRINTER

Resumen de: US2025241734A1

Disclosed are systems and methods of a decision intelligence (DI)-based computerized framework that automatically and/or dynamically implements a color algorithm for performing staining and glazing dental restorations. The framework operates by leveraging determined color variations through AI/ML-based analysis that generate detailed color maps, which can be translated into precise printing instructions controlling the mixture and layering of dental-grade glazing materials. A printing system can employ multiple print heads with varying base colors and opacity levels to create microscopic color gradients and translucency effects matching natural tooth enamel. The disclosed automated processing applies personalized color patterns in microscopically thin layers, ensuring consistent glaze thickness while replicating regional variations across the tooth surface. Such approach eliminates manual glazing variability while achieving superior customization compared to traditional pre-set patterns, resulting in dental restorations that integrate seamlessly with existing teeth.

FEATURES FOR IMPLANTS WITH A REDUCED VOLUMETRIC DENSITY OF SURFACE ROUGHNESS

Resumen de: US2025241765A1

The invention disclosed herein includes implant features that can be used, in some embodiments, on devices with a volumetric density of less than about 100 percent and devices with a surface roughness of some value. The implant features include one or more protrusions mounted on the forward edge of an implant that can ease the distraction of tissue during implantation and reduce the occurrence of damage during a manufacturing process. In some embodiments, the protrusions have gaps in a non-axial direction with respect to the implant to allow axial compression with respect to the protrusions. In some embodiments, the protrusions have a circumferential gap between them and a body of a device to reduce any impact on the device's elastic modulus.

Spinal Implant With Porous And Solid Surfaces

Resumen de: US2025241766A1

A spinal implant including porous and solid portions is disclosed. The implant includes porous portions on upper and lower surfaces and in an interior thereof. Methods of manufacturing and implanting such implants are also disclosed.

System and method for producing pharmaceutical objects via 3D printing

Nº publicación: AU2025205378A1 31/07/2025

Solicitante:

PHARMAPRINT LTD LLC
PharmaPrint Limited LLC

Resumen de: AU2025205378A1

21894047_1 (GHMatters) P119307.AU.2 The invention relates to a system for producing pharmaceutical objects, such as tablets, granules and capsules, via 3D print- ing. The system comprises a 3D printing machine (2) with a me-5 chanical system (3) movable in one or more directions, at least one print head (5) with a nozzle (37) being movable by the me- chanical system (3) and a base system (4) carrying a print base (6) for receiving a prepared mixture (27) applied by the print head (5). The system comprises at least one carrier (35) for 10 holding a cartridge (28).Printing can be done on formatted print locations (49) on the base (6). The invention further relates to a method for producing pharmaceutical objects, comprising the steps of providing at least one pharmaceutical substance in at least one cartridge, placing the cartridge in a carrier, estab-15 lishing a fluid connection between a cartridge and a print head, such that the pharmaceutical substance may leave the print head through the print head nozzle, moving the print head nozzle ac- cording to a 3D print program and dispensing the pharmaceutical substance to a print base. 20 (Fig. 24) The invention relates to a system for producing pharmaceutical objects, such as tablets, granules and capsules, via 3D print- 5 ing. The system comprises a 3D printing machine (2) with a me- chanical system (3) movable in one or more directions, at least one print head (5) with a nozzle (37) being movable by the me- chanical system (3)