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107
resultados
Última actualización
16/09/2025 [07:10:00]
Resultados 50 a 75 de 107
Resumen de: WO2024050627A1
Purified antigens are usually weakly immunogenic and require the addition of immunostimulatory agents and/or delivery systems to generate robust antigen-specific responses. The present application relates to self-assembling polypeptides that may be conjugated to immunogens and have the ability to self-assemble into immunogen-displaying nanofilaments that activate the humoral and cellular immune responses. The self-assembling polypeptide comprises an amino acid sequence having at least 60% identity with the sequence of the R4 and R5 domains from a Curli-specific gene A (CsgA) protein. The present application also relates to nucleic acids encoding the self-assembling polypeptide/immunogen conjugates, to compositions and vaccines comprising the self-assembling polypeptide/immunogen conjugates or nucleic acids, as well as to methods for inducing an immune response against an immunogen and/or for preventing and/or treating a microbial infection, cancer or any pathological conditions in which vaccination may be useful such as autoimmune diseases and allergies, in a subject.
Resumen de: CN120305383A
The invention belongs to the technical field of medicines, and particularly relates to application of 10-undecylenic acid and polymyxin in preparation of an antibacterial drug, and the antibacterial drug aims at one or more of escherichia coli, salmonella and klebsiella pneumoniae. The antibacterial agent aims at bacteria which are resistant to polymyxin. The bacteria directed by the antibacterial agent are multi-drug-resistant gram-negative bacteria. Through a chessboard method minimum inhibitory concentration test, an in-vitro bacterial growth curve proves that 10-undecylenic acid synergistically enhances the antibacterial activity of polymyxin, and meanwhile, a mouse drug-resistant bacterial infection model test proves that 10-undecylenic acid can effectively enhance the in-vivo effectiveness of polymyxin at the animal level. The invention provides a new application of 10-undecylenic acid in enhancing the antibacterial activity of polymyxin antibiotics, and can solve the technical problems of low clinical drug resistance and therapeutic index of polymyxin and the like.
Resumen de: CN120314573A
The invention provides a polysaccharide antigen derived from salmonella pullorum and marked by fluorescent molecules as well as a preparation method and application of the polysaccharide antigen. The invention provides a simple, convenient and rapid extraction method of the salmonella pullorum polysaccharide antigen, and the polysaccharide antigen for bacterial serological detection is prepared by combining fluorescence labeling on the basis of the experimental principle of fluorescence polarization. The polysaccharide antigen prepared according to the method provided by the invention can be used for serological detection of salmonella pullorum and has good sensitivity, and a new method is provided for detection of salmonella pullorum infection.
Resumen de: CN120309697A
The invention discloses a polypeptide drug for resisting gram-negative bacteria and application, and belongs to the technical field of biological medicine. The MIC of the antibacterial peptide obtained through screening on escherichia coli, salmonella typhimurium, pseudomonas aeruginosa, klebsiella pneumoniae, shigella sonnei and stenotrophomonas maltophilia is 16 mu g/mL, 2 mu g/mL, 16 mu g/mL, 4 mu g/mL, 2 mu g/mL and 4 mu g/mL respectively, and the antibacterial peptide has broad-spectrum antibacterial performance. The hemolytic activity and toxicity of the compound are lower than therapeutic concentration threshold values, and the compound can be used for preparing drugs or medical products for treating multi-drug-resistant bacterium infection.
Resumen de: CN120284881A
The invention discloses preparation and application of micromolecular coated oncolytic bacteria, and relates to the field of nano-drugs. According to the coated bacteria, the surface of attenuated salmonella VNP20009 is coated with a nano-coating formed by coordination of micantrone and calcium ions, a bacterial antigen signal is shielded, so that the peripheral clearance rate and toxicity risk of the attenuated salmonella VNP20009 in blood circulation are reduced, and the coated bacteria have good biocompatibility and can maintain natural physiological characteristics and biodegradability of the bacteria. In order to solve the problems of lack of effective molecular targets and high immunosuppression of triple negative breast cancer (TNBC), the coated oncolytic bacteria utilize the natural tropism of VNP20009 on TNBC and the physiological targeting motion characteristic to directionally deliver miltroquinone and calcium ions, and cooperate with the oncolytic bacteria to kill tumor cells; bacterial surface antigen signals are shielded, so that tumor accumulation is increased, peripheral toxicity is avoided, and a breakthrough is provided for overcoming long-term failure of oncolytic bacteria clinical tests.
Resumen de: CN120288855A
The invention discloses a preparation method of nano ozone water and application of the nano ozone water in killing food-borne pathogenic bacteria, and belongs to the technical field of bactericides. The nano ozone water is prepared by utilizing the ultra-fine bubble generator and the ozone generator, and the prepared nano ozone water is high in stability, not easy to decompose and high in practicability. The nano ozone water can achieve an effective killing effect on escherichia coli, salmonella, enterococcus, campylobacter and clinical multi-drug-resistant bacteria thereof, and a new resource is provided for preparing a safe and reliable antibacterial product.
Resumen de: CN120290758A
The invention discloses a campylobacter jejuni rapid detection method and a kit based on a specific molecular target rpoZ. The sequence of the molecular target is as shown in SEQ ID NO. 1. The PCR/qPCR detection kit for detecting campylobacter jejuni is established on the basis of the target rpoZ, has extremely high specificity, only has specific amplification signals for nucleic acid of campylobacter jejuni, and has no cross reaction for other common food-borne pathogenic bacteria such as escherichia coli, salmonella and staphylococcus aureus. Meanwhile, the sensitivity is high, and the nucleic acid detection target can detect the campylobacter jejuni genome DNA as low as 132fg/mu L. The method can effectively detect campylobacter jejuni in samples such as food, is high in specificity, good in accuracy and simple to operate, and can be applied to the fields of food safety and the like.
Resumen de: CN120290757A
The invention belongs to the technical field of biological detection, and discloses a multiple qPCR (quantitative polymerase chain reaction) kit for detecting food-borne pathogenic bacteria of aquatic products and application of the multiple qPCR kit. The kit comprises primers and a probe group for detecting vibrio parahaemolyticus, listeria monocytogenes and salmonella, and the sequences of the primers and the probe group are as shown in SEQ ID NO.1-9. According to the invention, probes with different fluorescence labels are utilized to realize simultaneous detection of three food-borne pathogenic bacteria of vibrio parahaemolyticus, listeria monocytogenes and salmonella in aquatic products. The method has the characteristics of short time consumption, good specificity, high sensitivity, high economic benefit and the like, has important significance on molecular diagnosis of the food-borne pathogenic bacteria in the aquatic products, and meets the detection requirements of simultaneously detecting the three food-borne pathogenic bacteria in the aquatic products.
Resumen de: CN120290363A
The invention discloses lactococcus formosanus with coaggregation capacity with helicobacter pylori and application of the lactococcus formosanus, and belongs to the technical field of microorganisms and the technical field of medicines. The lactococcus formosanus CCFM1461 screened by the invention has relatively strong gastric environment tolerance and acid production capacity, the copolymerization rate of the lactococcus formosanus CCFM1461 and helicobacter pylori within 120 minutes can reach 69.94%, the adhesion of the helicobacter pylori in AGS cells can be reduced, and the adhesion rate of the helicobacter pylori is reduced by 43.79%; the strain also has strong co-aggregation ability with other pathogenic bacteria (Escherichia coli, Staphylococcus aureus, Shigella, Salmonella typhimurium and Pseudomonas fluorescens), and has huge application prospects in the aspects of removal of helicobacter pylori, preparation of a helicobacter pylori adhesion scavenger and the like.
Resumen de: CN120285059A
The invention belongs to the technical field of veterinary drugs, and discloses a Chinese pulsatilla root alcohol extract and gentamicin composition and application thereof in inhibition of drug-resistant salmonella typhimurium. The pulsatilla alcohol extract composition provided by the invention comprises pulsatilla alcohol extract and gentamicin, and for salmonella typhimurium, the optimal ratio concentration of the pulsatilla alcohol extract to the gentamicin is 31.25 mg/mL: 2 mu g/ml; the Chinese pulsatilla root alcohol extract and the gentamicin have the synergistic bacteriostatic effect on salmonella typhimurium, the composition reduces the concentration of single bacteriostasis of the Chinese pulsatilla root alcohol extract and the gentamicin, the cost is saved, and the composition has wide application prospects and development value in the fields of food processing, medicine and breeding industry.
Resumen de: CN120290433A
本发明公开了一种基于鞭毛蛋白和LPS减毒的鼠伤寒沙门氏菌EN‑VNP菌株及其制备方法和应用，具体涉及生物技术领域。该菌株是通过在沙门氏菌VNP 20009菌株基础上，依次敲除或沉默鞭毛蛋白基因fliC、fljB、磷酸乙醇胺转移酶基因eptA、4‑氨基‑4‑脱氧‑L‑阿拉伯糖转移酶基因arnT、磷酸转移酶yeiU，并敲入或过表达磷酸转移酶基因lpxE形成的。本发明的鼠伤寒沙门氏菌EN‑VNP菌株具有较高的安全性，减毒后的菌株不含有鞭毛蛋白且LPS的脂质A分子仅保留一个磷酸基团，提高了菌株的安全性，使其更适合作为疫苗和药物递送载体。
Resumen de: CN120285052A
The invention discloses an application of herba schizonepetae essential oil in preparation of a salmonella pigeonae resisting medicine. The herba schizonepetae essential oil is extracted by adopting a steam distillation method. The herba schizonepetae essential oil provided by the invention shows an obvious inhibition effect on salmonella pigeons. The herba schizonepetae essential oil is natural in source and simple in preparation method, and has important application value in the aspect of preparing anti-salmonella pigeon.
Resumen de: CN120290423A
The invention relates to the technical field of microorganisms, in particular to bacillus licheniformis JSF-9 and a complex microbial inoculant and application thereof.The strain JSF-9 is obtained by being separated from healthy cattle rectum contents by a research group, and it is detected that the strain has the good beta-1, 4-glucanase producing capacity, and the beta-1, 4-glucanase producing capacity is high. The antibacterial effect on staphylococcus aureus, salmonella typhimurium and shigella flexneri is achieved; the strain has a good bagasse fermentation capability, for example, after the strain, bacillus altitudinis MLF-1 and bacillus safensis MLL-5 are prepared into a mixed microbial inoculum, the bagasse fermentation capability is better, and verification shows that the complex microbial inoculum can effectively inhibit the reproduction of harmful bacteria, so that the preservation period of fermented feed is prolonged, and the yield of the fermented feed is improved. Animal feeding experiments find that the nutritional value and the disease resistance of the complex microbial inoculant fermented bagasse are remarkably improved, 10-15% of the complex microbial inoculant fermented bagasse is added into basic ration, and the cost-reducing and effect-increasing effects are achieved for feeding Jersey cattle.
Resumen de: CN120285163A
The invention relates to the technical field of gene engineering, in particular to application of an RNF213 carboxyl terminal E3 structural domain or a coding gene thereof or a biological material containing the coding gene thereof in product preparation. The application of the RNF213 E3 structural domain in regulating the innate immune pathway is disclosed for the first time, and a powerful scientific basis and a tool are provided for prevention, control and treatment of bacteria such as salmonella and the like. The constructed vector containing the RNF213 E3 structural domain can significantly improve the expression level of immune factors, promote the activity of an NF-kappa B pathway and reduce the cell bacterium loading amount, provides a thought for scientific research and industrial application related to prevention and control of gram-negative bacteria such as salmonella, and lays a scientific foundation.
Resumen de: CN120290759A
The invention discloses a method and a kit for rapidly detecting campylobacter jejuni based on a specific molecular target glnp. The sequence of the molecular target is as shown in SEQ ID NO. 1. The PCR/qPCR detection kit for detecting campylobacter jejuni is established based on the target glnp, has extremely high specificity, only has a specific amplification signal for nucleic acid of campylobacter jejuni, and does not have any cross reaction for other common food-borne pathogenic bacteria such as escherichia coli, salmonella and staphylococcus aureus. Meanwhile, the sensitivity is high, and the nucleic acid detection target can detect the campylobacter jejuni genome DNA as low as 132fg/mu L. The method has the advantages of short detection time, high specificity, high detection sensitivity, simplicity in operation and the like.
Resumen de: CN120290742A
The invention discloses an identification marker and an identification method for germplasm of Salmonella salmon, and relates to an identification method for Salmonella salmon. According to the method, the problem of shortage of a Salmon salmon germplasm identification technology is solved. The method comprises the following steps: 1, extracting genome DNA of a to-be-identified sample; 2, carrying out PCR (Polymerase Chain Reaction) amplification by using a species specific primer; 3, agarose gel electrophoresis, recovery and purification; and 4, sequencing the purified PCR product, comparing the sequencing result with an identification sequence, splicing a homologous sequence, and comparing the difference of five basic groups positioned at the 15th bp, the 23rd bp, the 29th bp, the 39th bp and the 84th bp. The molecular marker is used for identifying the salmon arsalmonella, the salmon americana, the oncorhynchus masou and the oncorhynchus mykiss, has the characteristics of high efficiency, rapidness, stable result and high accuracy, and has important application value in the aspect of germplasm identification of the salmon arsalmonella.
Resumen de: US2025224367A1
Disclosed herein are biosensors, and, more particularly, biosensors using carbon nanotubes, an electronic reader for use with the biosensors, and systems and methods employing them. The biosensors employ preserved biologics on the carbon nanotubes which results in shelf-stable, robust biosensors.
Resumen de: US2025222089A1
Provided are compositions and methods that include a K. pneumoniae yidR protein or an antigenic segment of the protein, and homologous of the protein, and antigenic segments of the homologs. The compositions can be provided as vaccine formulations for use with humans and non-human animals, including but not limited to dairy cows. The compositions and methods are useful for prophylaxis and/or therapy of conditions associated with Gram negative bacteria that include K. pneumonia, E. coli, and other pathogenic Gram negative bacteria. The conditions include such bacterial infections generally, and include specifically mastitis and metritis. The compositions and methods can also improve fertility and milk production. Administration of the compositions can improve the likelihood of a first service conception.
Resumen de: US2025222101A1
A composition for treatment of African Swine Fever in swine includes avian-sourced antibodies specific for an African Swine Fever Virus isolate. These antibodies are produced by avian animals immunized against the African Swine Fever Virus isolate and mixed with a protective/reactive matrix obtained from, isolated from, or derived from, non-hyperimmune colostrum.
Resumen de: CN120272384A
The invention relates to the technical field of microorganisms, in particular to bacillus safensis MLL-5 and a complex microbial inoculant and application thereof.The strain MLL-5 is separated from rumen contents of healthy cattle by a research group, and it is detected that the strain has the good beta-1, 4-glucanase producing capacity and can be used for producing beta-1, 4-glucanase. The antibacterial effect is achieved on escherichia coli, yersinia enterocolitica, shigella flexneri and salmonella typhimurium; the bacillus safensis MLL-5 has relatively good fermentation capability on the cassava residues, can effectively reduce the cyanide content of the cassava residue fermented feed and improve the protein content of the cassava residue fermented feed, is a good biological fermentation agent aiming at the cassava residues, and has good application prospects. After Jersey cattle are fed with manioc waste fermented feed prepared from the strain and the complex microbial inoculant, it is found that addition of 10%-15% of fermented manioc waste into daily ration does not have adverse effects on the growth performance and health conditions of the cattle, the number of diarrhea times is obviously reduced, and the manioc waste fermented feed is safe.
Resumen de: CN120267813A
本发明涉疫苗领域，具体而言涉及一种CpG佐剂与抗原定点共价结合方法。本发明方法采用分步偶联策略，使用HUH蛋白与相匹配的特异性识别ssDNA序列偶联系统、异肽键分子粘合剂系统以及融合表达系统等实现CpG佐剂与抗原以1:1的摩尔比定点偶联，并且所得到的偶联物具有提高疫苗的免疫刺激的效果。
Resumen de: CN120266989A
The invention discloses a hermetia illucens breeding feed and a preparation method thereof, and belongs to the technical field of feeds. The hermetia illucens breeding feed comprises a microbial preparation, kitchen garbage, natural substances, meal substances and modified shell powder. The modified shell powder is prepared from acid-treated shell powder. The invention also provides a preparation method of the composition. According to the application, the specially modified shell powder is synergistically used with the natural plant extract and the compound probiotics, so that synergism and unification of four targets of nutrition, antibiosis, deodorization and environmental stability are realized, and growth of pathogenic bacteria such as salmonella and escherichia coli is effectively inhibited; the problem of corruption caused by humidity and ventilation conditions of the breeding environment can be improved for a long time. The modified shell powder is used as a composite functional carrier, a probiotic attachment and stable release platform is provided by utilizing a porous structure of the modified shell powder, and the survival rate and the resource conversion efficiency of the hermetia illucens are systematically improved by combining with the continuous effect of natural active substances, so that the method has good innovativeness and practicability.
Resumen de: CN120267709A
The invention discloses a method for establishing a salmonella pullorum challenge model, and relates to the technical field of biological medicines. The invention discloses a method for establishing a salmonella pullorum challenge model. The method comprises the following steps: taking a 12-day-old chick embryo, and injecting a chitosan oligosaccharide solution into a chick embryo air chamber; placing the chick embryos injected with the chitosan oligosaccharide solution into an incubator for incubation until the chick embryos are 14 days old; salmonella pullorum is injected into an air chamber of the 14-day-old chick embryo for challenging; after challenging the chick embryos, continuously incubating the chick embryos in an incubator until 21 days old; and after the chick embryos are incubated to 21 days old, hatched and changed into chicks, establishing a toxic attack model. According to the invention, the method of the challenge model is creatively optimized, and the optimal chitosan solution injection concentration and the optimal challenge concentration of salmonella pullorum are screened; the salmonella pullorum challenge model is built through the method, the highest morbidity and survival rate of chicks can be controlled after 24 h, and it can be guaranteed that the morbidity time is uniform.
Resumen de: CN120253780A
The invention belongs to the technical field of rapid detection of food and agricultural products, and particularly relates to a fluorescent colorimetric card based on fluorescent nanofibers and a method for rapidly detecting hydrogen sulfide gas by using the fluorescent colorimetric card. The method comprises the following steps: firstly, synthesizing gold nanoclusters; then modifying a vinyl alcohol-ethylene copolymer nanofiber membrane based on the synthesized gold nanoclusters, and finally preparing the fluorescent colorimetric card based on the vinyl alcohol-ethylene copolymer nanofiber membrane modified by the synthesized gold nanoclusters. The fluorescent colorimetric card prepared by the invention can realize visual reading of hydrogen sulfide gas response signals, so as to realize qualitative identification of salmonella typhimurium in food. Moreover, the prepared fluorescent colorimetric card has the advantages of low cost, portability, visual detection and the like, is suitable for non-destructive detection of salmonella typhimurium in multiple scenes, and has important significance for guaranteeing the safety of food and agricultural products.
Nº publicación: CN120249162A 04/07/2025
Solicitante:
中国动物卫生与流行病学中心
Resumen de: CN120249162A
本发明提供一种减毒鼠伤寒沙门氏菌及其应用，所提供的减毒鼠伤寒沙门氏菌，是通过敲除relA基因、manA基因和sifA基因制备的。本发明所提提供的三基因沙门氏菌减毒株，通过口服免疫将抗原呈递给宿主细胞，从而诱导机体产生免疫应答。沙门氏菌作为活载体的作用机理为携带细菌抗原通过肠道上皮后，通过肠道粘膜将其转运至免疫细胞，触发了宿主的免疫应答。本发明构建的减毒株经安全性检测发现，该减毒株安全性高，可作为载体，运载其他致病抗原或药物到达作用部位，进而起到载体作用。
BOPI
Sede Electrónica
