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Composite preparation containing bovine lactoferrin and lyase and application thereof

Resumen de: CN121154798A

The invention discloses a compound preparation containing bovine lactoferrin and lyase and application of the compound preparation, and belongs to the technical field of biology. The preparation is composed of bovine lactoferrin and streptococcus lyase which are both prepared through a baculovirus-insect cell eukaryotic expression system. Researches show that the compound preparation has a remarkable synergistic antibacterial effect. The streptococcus lyase not only can effectively inhibit various gram-positive bacteria, but also can overcome the limitation that single streptococcus lyase has weak activity on gram-positive bacteria, and obviously enhances the inhibition effect on escherichia coli and salmonella. Particularly, the preparation still has definite in-vitro bacteriostatic activity on multi-drug-resistant escherichia coli such as ciprofloxacin and doxycycline, and a new way is provided for developing novel drugs for resisting drug-resistant bacteria.

Salmonella low water activity tolerance prediction method, device and system, and storage medium

Resumen de: CN121171360A

The invention discloses a salmonella low water activity tolerance prediction method, device and system and a storage medium, and the method comprises the steps: collecting salmonella genome data in a public database, and recording the water activity information of a source; processing the genome data to form a data matrix; performing redundancy elimination operation on the data matrix; dividing the data matrix; respectively carrying out model training through three machine learning algorithms by using the data matrix; obtaining an optimal performance model based on a Bayesian parameter adjustment method; and the low water activity tolerance of the salmonella is judged based on prediction of three algorithm models. By adopting the technical scheme provided by the invention, the problems of insufficient prediction coverage caused by dependence on a single gene marker and overfitting caused by high whole genome feature redundancy in the prior art are solved.

PRIMER AND PROBE FOR DETECTING SALMONELLA PULLORUM, AND KIT

Resumen de: WO2025255902A1

A primer and probe for detecting Salmonella pullorum, and a kit. The primer comprises SP-F and SP-R for detecting the target sequence of the Salmonella pullorum (SP) citE2 gene, and the probe is modified with a fluorescent reporter group and a fluorescent quenching group. By means of providing the primer pair of SP-F and SP-R, which pair specifically binds to the target sequence of the citE2 gene, and combining the primer pair with the probe, whic is used for specific recognition, the accurate and sensitive detection of Salmonella pullorum can be realized.

ANTI-BACTERIAL PROTEIN COMPLEX

Resumen de: MX2025009214A

The invention relates to protein bacteriocins (PBs) as therapeutic agents, and specifically to protein complexes comprising two or more PB molecules associated with a protein scaffold which comprises cognate immunity protein domains for the effector portions of the respective PBs. In particular, the invention provides an anti-bacterial protein complex comprising (a) a first PB molecule and a second PB molecule; and (b) an immunity protein scaffold comprising a first immunity protein domain and a second immunity protein domain; wherein the first and second immunity protein domains are non-covalently bound to the respective first and second PB molecules.

ADI Attenuated Salmonella Gallinarum expressing ADI and uses thereof

Resumen de: KR20250175381A

본 발명은 항암 물질인 아르기닌 디이미나아제 (arginine deiminase; ADI)를 발현하는 항종양 박테리아 균주 및 이의 용도에 관한 것으로, 본 발명에 따른 항암 물질 생산 시스템이 도입된 면역 활성능이 있는 살모넬라 균주는 우수한 면역 항암 효능을 나타내어, 기존 항암제와 함께 또는 독립적으로 암의 치료제로 사용될 수 있다.

Rapid immunochromatography detection kit for gastrointestinal pathogenic bacteria based on viral nano-enzyme probe

Resumen de: CN121142029A

The invention belongs to the technical field of biological detection, and discloses a rapid immunochromatography detection kit for gastrointestinal pathogenic bacteria based on a viral nano-enzyme probe. The invention discloses a nano-enzyme probe, the virus-shaped nano-enzyme probe provided by the invention takes Fe3O4 nano-particles as a core, Pt nano-particles and Au (at) Pt nano-particles are coated in sequence, a specific antibody is modified, and the nano-enzyme probe has a magnetic enrichment effect and a multi-catalytic-site characteristic at the same time; rapid capture and high-sensitivity quantitative detection of various gastrointestinal pathogenic bacteria in complex matrixes (river water samples, lake water samples and excrement samples) can be realized, and matrix interference in practical application is eliminated; and the kit has huge potential in the aspects of high-sensitivity field screening and clinical monitoring of infection of gastrointestinal bacteria (such as escherichia coli, salmonella and helicobacter pylori).

Establishment method and application of pigeon salmonella acute infection model

Resumen de: CN121129906A

The invention belongs to the technical field of biology, and particularly relates to an establishment method and application of a pigeon salmonella acute infection model. The establishment method comprises the following steps: infecting a squab by adopting pigeon source salmonella typhimurium obtained by separation and screening in a subcervical multi-point injection manner, and preparing to obtain a pigeon salmonella acute infection model; the pigeon source salmonella typhimurium is preserved in the general microbiological center of the China Committee for Culture Collection of Microorganisms on August 25, 2025, and the preservation number of the pigeon source salmonella typhimurium is CGMCC N0.35198. According to the establishment method, the technical problems of low success rate and poor replication rate of an existing modeling method are solved, the pigeon salmonella acute infection model established by the method improves the modeling success rate and uniformity, is long in disease course and stable, can assist in research and development of drugs for preventing and treating pigeon salmonella infection, and can realize effective and objective evaluation of the drug effect.

一种CeO2-Au复合材料结合TDN-MultiApt形成的MNP-DNA-Apt复合体及制备方法与应用

Resumen de: CN121142039A

本发明公开了一种CeO2‑Au复合材料结合TDN‑MultiApt形成的MNP‑DNA‑Apt复合体及制备方法与应用，所述的复合体是通过下述方法制备得到的：先构建立方体c‑CeO2‑Au纳米颗粒，再构建DNA‑CeO2‑Au探针（DA探针），然后利用四个单链DNA样品构建TDN结构，并通过碱基互补配对与适配体Apt链接，形成TDN‑MultiApt；TDN‑MultiApt通过抗原‑抗体反应和碱基互补配对分别与链霉亲和素修饰的磁珠MNP和DA探针结合形成MNP‑DNA‑Apt复合体，即形成MDA探针。本发明中的立方体CeO2‑Au结合TDN‑MultiApt比色传感系统突破了传统的基于培养和其他分子诊断技术的局限性，该系统通过比色模式进行检测，适用于现场快速检测，突出了其作为现场检测解决方案的潜力。

Bian chicken source bacillus licheniformis and application thereof

Resumen de: CN121136879A

The invention discloses Bian chicken source bacillus licheniformis and application thereof, and belongs to the technical field of microorganisms, the Bian chicken source bacillus licheniformis is named as bacillus licheniformis YYBJ-06-01 and preserved in the China Center for Type Culture Collection (CCTCC), and the preservation number is CCTCC No.M 20252095. The Bian chicken source bacillus licheniformis is named as bacillus licheniformis YYBJ-06-01, and the Bian chicken source bacillus licheniformis is named as bacillus licheniformis YYBJ-06-01 and preserved in the China Center for Type Culture Collection (CCTCC). The Bian chicken source bacillus licheniformis can significantly enhance the immunity of the organism, increase the content of serum immune globulin IgG and reduce the level of inflammatory factors. Meanwhile, the serum antioxidant enzyme activity can be effectively improved, the malondialdehyde content is reduced, and the antioxidant function of the body is enhanced. Besides, the Bian chicken source bacillus licheniformis has a definite inhibition effect on common pathogenic bacteria such as escherichia coli, salmonella and the like, is sensitive to most of common antibiotics and high in biological safety, and provides an excellent strain resource for developing a green feed additive for replacing the antibiotics.

Application of ramoplanin as antibacterial synergist of polymyxin antibiotics

Resumen de: CN121130046A

The invention belongs to the technical field of antibacterial synergists, and discloses application of ramoplanin as a colistin antibacterial synergist. The invention provides a treatment strategy for combined use of ramoplanin as a polymyxin drug sensitizer in treatment of gram-negative bacterial infection, and in a test of combined use of ramoplanin and colistin for detection of a bacterial sterilization curve and the integrity of a bacterial outer membrane, the concentration of the ramoplanin is low and is only 16 mu g/mL; in the aspect of the antibacterial effect, the FICI index is relatively low, and after the ramoplanin and the colistin are jointly used, the MIC (Minimum Inhibitory Concentration) of the colistin can be reduced by 16 times at most. The research shows that ramoplanin is a promising antibiotic sensitizer, and can be used in combination with the polymyxin drug colistin to resist the colistin drug resistance problem of escherichia coli, salmonella and klebsiella pneumoniae.

Application of traditional Chinese medicine composition in preparation of medicine for preventing and/or treating bacterial infectious diarrhea

Nº publicación: CN121130030A 16/12/2025

Solicitante:

ANHUI LEI YUN SHANG PHARMACEUTICAL CO LTD
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Resumen de: CN121130030A

The invention belongs to the technical field of medicines, and particularly relates to application of a traditional Chinese medicine composition in preparation of a medicine for preventing and/or treating bacterial infectious diarrhea. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 30 to 60 parts of rhizoma coptidis, 30 to 60 parts of cortex magnoliae officinalis, 5 to 20 parts of radix aucklandiae and 5 to 20 parts of rhizoma zingiberis. The bacterial infectious diarrhea is bacterial infectious diarrhea caused by salmonella. The traditional Chinese medicine composition prepared by the invention can obviously improve the diarrhea condition of mice, improve the weight loss condition of the mice, reduce the inflammation level and relieve the lesion degree of intestinal tissues.