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107
resultados
Última actualización
16/09/2025 [07:10:00]
Resultados 75 a 100 de 107
Resumen de: CN119744171A
The present disclosure relates to novel therapeutic regimens for the treatment of autoimmune and other inflammatory diseases using BTK (Bruton's Tyrosine Kinase) inhibitors. In particular, the present disclosure relates to treatments that combine BTK inhibitor treatments with vaccination to avoid, reduce the risk of staining, or ameliorate infection. In addition, the present disclosure relates to vaccination in the presence of a BTK inhibitor.
Resumen de: WO2025143588A1
The present invention relates to a spheroplast protein y (Spy)-exogenous protein-secreting Salmonella strain, which possesses a Spy protein-coding gene and has the rpoE gene deleted. The recombinant Salmonella strain according to the present invention, while exhibiting attenuated virulence due to the Spy protein, can maintain structural stability when fused with exogenous proteins such as pathogenic viruses, therapeutic proteins, or antigenic epitopes, through the structure and chaperone functions of the Spy protein. Therefore, the present invention can serve as a live attenuated vaccine. Furthermore, the present invention can be used as a protein delivery vehicle, a drug delivery vehicle, and in antigen-antibody reaction-based techniques for applications in other areas of biotechnology.
Resumen de: CN120230694A
本发明提供一种同时缺失invF基因、spaL基因、sipC基因、prgH基因中的两种或两种以上的多基因缺失的鼠伤寒沙门菌。本发明还公开了上述多基因缺失的鼠伤寒沙门菌的构建方法，及其在制备鼠伤寒沙门菌减毒活疫苗中的应用。本发明提供的四基因同时缺失的鼠伤寒沙门菌缺失株较野生型鼠伤寒沙门菌的毒力显著下降，在宿主体内的定殖时间显著缩短，接种后小鼠无不良反应，对强毒力鼠伤寒沙门菌提供良好的保护作用，可有效清除强毒力菌株的感染；应用于鼠伤寒沙门菌减毒活疫苗具有良好的免疫原性，可对小鼠提供坚实的免疫保护效果，具有广泛的应用前景。
Resumen de: CN120204382A
The invention discloses a novel Kdo-MPLA adjuvant, and relates to the technical field of synthetic biology, the adjuvant is formed by connecting monophosphate lipid A (MPLA) and Kdo sugar through an alpha-glucosidic bond, MPLA is of a structure formed by modifying salmonella lipid A through 4 '-site monophosphorylation, and the Kdo sugar is endowed with amphipathy, so that the Kdo sugar is self-assembled into liposome nanoparticles in an aqueous solution; the rfaC and eptA genes are double knocked out through a gene editing salmonella attenuated strain, wherein the rfaC knockout blocks the synthesis of LPS core polysaccharide, and lipid A-Kdo connection is reserved; knocking out eptA to obtain a monophosphorylated lipid A; after the engineering bacteria are fermented, high-purity Kdo-MPLA is obtained by adopting a phenol-chloroform-petroleum ether extraction method, the process is simplified, and the product is uniform; the adjuvant can activate a TLR4 signal channel and induce Th1 type immune response, the levels of inflammatory factors IL-6 and IL-1beta are remarkably lower than those of natural LPS, and the adjuvant is suitable for a mixed preparation of vaccine antigens such as HPV and malaria; the method overcomes the defects of hydrolysis uncontrollability and high chemical synthesis cost of the traditional MPLA chemical extraction process.
Resumen de: CN120210147A
The invention discloses a high-activity transaminase mutant with L-alanine as an amino donor and application of the high-activity transaminase mutant in synthesis of L-glufosinate-ammonium, and provides a novel high-activity transaminase mutant from salmonella, L-alanine is used as the amino donor to asymmetrically synthesize L-glufosinate-ammonium, so that the use amount of L-alanine is reduced, the cost is reduced, and the yield of L-glufosinate-ammonium is increased. And the space-time conversion rate is improved, and the industrial production cost is reduced.
Resumen de: CN120209102A
本发明涉及一种赖氨酸光学探针及其制备方法和应用。一方面，本发明涉及一种光学探针，包含赖氨酸敏感多肽或其功能变体和光学活性多肽或其功能变体，其中光学活性多肽或其功能变体位于赖氨酸敏感多肽或其功能变体的序列内。本发明也涉及上述探针的制备方法及其在检测赖氨酸中的应用。
Resumen de: CN120210397A
The invention provides a novel salmonella molecular detection method based on an EXPAR-CRISPR/Cas12a detection system, the method specifically amplifies a yfiR gene of salmonella through an EXPAR isothermal technology, and uses a CRISPR/Cas12a system for cutting and detection, and has the advantages of rapidness, sensitivity, strong specificity and the like.
Resumen de: CN120205817A
The invention particularly relates to ceramic for an antibacterial fruit knife and a manufacturing process of the ceramic, and belongs to the technical field of ceramic products. The antibacterial ceramic for the fruit knife is prepared from the following raw materials in parts by mass: 20 to 30 parts of nano chitin, 15 to 20 parts of nano Si3N4, 18 to 20 parts of nano ZrO2, 12 to 15 parts of nano ferrotitanium powder, 8 to 10 parts of potassium feldspar, 5 to 10 parts of aluminum oxide, 2.5 parts of graphene and 5 parts of a calcium-zinc stabilizer. The ceramic has an antibacterial effect, and the antibacterial rate on escherichia coli, pseudomonas aeruginosa, bacillus pumilus, salmonella typhimurium, staphylococcus, acinetobacter calcoaceticus and the like is up to 99% or above; meanwhile, the ceramic material has high hardness and good bending strength and can be used for manufacturing the ceramic fruit knife; the manufacturing process adopts hot-pressing one-time forming, and is simple, energy-saving and environment-friendly.
Resumen de: WO2025134131A1
PROCESS FOR PREPARATION OF NATURAL AND ORGANIC POTASSIUM SORBATE The present invention relates to the process for production of natural and organic potassium sorbate. The natural and organic potassium sorbate is produced through microbial fermentation of natural carbohydrate source obtained from organic raw material tuber crop cassava followed by downstream processing steps of filtration, carbon treatment, evaporation, centrifugation and spin flash drying. The fermentation was carried out utilizing the Lactobacillus delbrueckii NCIM 2365, Bacillus coagulans MTCC 3543 and Lactobacillus acidophilus NCIM 5705, which were modified by the way of strain improvement through media optimization, filtration, carbon treatment, evaporation and centrifugation, the pellet material received was further dried in spin flash dryer resulting in finished product in powder form as potassium sorbate with sorbic acid (70-72%), other organic acids (10%),bioavailable potash (12%) and moisture (<5%). The natural and organic potassium sorbate powder produced has antimicrobial activity and addition of 0.1 to 0.5 % of the said natural preservative in food preparation of different food products like cheese and paneer, pickles, meat products, beverages like wines, canned food items, storage food items and bakery preparations enhances the shelf life of the product. It kills variety of food pathogens viz. Listeria sp., Salmonella sp., and Shigella sp in breads, paneer and pickles and on crops as foliar an
Resumen de: US2025206809A1
The invention provides anti-ETEC adhesin protein antibodies and methods of using the same.
Resumen de: US2025207141A1
Methods for making synthetic gene clusters are described.
Resumen de: US2025205325A1
The present invention relates to proteins and nucleic acids derived from Klebsiella pneumoniae as well as therapeutic and diagnostic uses of the proteins and nucleic acids.
Resumen de: KR20250092807A
본 발명은 살모넬라 속(Salmonella spp.) 균주에 특이적인 사멸능을 갖는 신규한 박테리오파지 KFSST2 및 이를 포함하는 항균 조성물에 관한 것으로, 상기 박테리오파지 KFSST2는 살모넬라균을 특이적으로 사멸시키는 효과를 가지며 높은 특이성 및 우수한 용균 활성을 나타냄으로써, 항생용 조성물, 살모넬라균에 의한 감염성 질병의 예방 또는 치료용 조성물, 사료 첨가용 조성물, 소독제, 또는 세척제 분야에서 다양하게 사용될 수 있다. 또한, 상기 박테리오파지 KFSST2 또는 이를 포함하는 항생제를 제공함으로써, 항생제 내성균의 문제점, 식품 내의 항생제의 잔류 문제, 광범위한 숙주 범위의 문제점을 해결 할 수 있는 이점이 있다.
Resumen de: US2025025552A1
The present invention provides methods and compositions for specific activation of inflammatory responses in dendritic cells (DCs). 1-palmitoyl-2-arachidonyl-sn-glycero-3-phosphorylcholine (PAPC) and its oxidized variant (oxPAPC) were identified to promote DC-mediated immunity, and are provided as adjuvants in immunostimulatory compositions, including vaccines.
Resumen de: CN120192933A
The invention discloses salmonella bacteriophage as well as a composition and application thereof, and belongs to the technical field of microorganisms. The bacteriophage provided by the invention is wide in splitting spectrum and strong in splitting capacity, and is remarkably characterized in that the bacteriophage has a good sterilization effect on salmonella of different serotypes in a low-temperature (4 DEG C) environment, does not contain soluble source, drug-resistant and virulence genes, has efficient replication capacity and splitting activity, is strong in high-temperature resistance and acid and alkali resistance, and can be used for preparing salmonella. And a conventionally used disinfectant has no influence on the disinfectant. The salmonella bacteriophage provided by the invention has great significance for preventing and treating salmonella infection.
Resumen de: CN120192426A
本发明涉及一种预防沙门氏菌感染的融合蛋白、免疫原性组合物、重组疫苗以及分子架构设计和应用等。本发明选取能够在真核细胞中顺利表达的PstS‑LpfB、PstS‑YidR、LpfB‑SinH三种融合蛋白设计进行动物免疫实验，验证保护效果。本发明发现PstS‑LpfB等融合蛋白分子可减弱沙门氏菌感染引起的组织病变，具有良好的免疫原性，起到有效预防和免疫保护作用，高效预防沙门氏菌感染，具有广泛的应用前景。
Resumen de: CN120192374A
The invention belongs to the technical field of cyclic peptide synthesis and biological medicine, and particularly relates to a cyclic peptide for inhibiting T3SS activity by targeting SctV and application of the cyclic peptide. Specifically, a series of macrocyclic peptides targeting InvA (derived from SctV protein of salmonella T3SS) are screened from a cyclic peptide library, and the macrocyclic peptides are proved to have the function of inhibiting the T3SS function, so that the optimal cyclic peptide CP-L1 is subjected to mutation optimization treatment, and a mutant peptide with a broad-spectrum antibacterial effect is obtained. As a promising antibacterial agent, the cyclic peptide provided by the technical scheme can be used for preventing and treating related diseases mediated by gram-negative pathogenic bacteria, so that the cyclic peptide has a good practical application value.
Resumen de: CN120195170A
The invention relates to the technical field of poultry breeding, in particular to a method for judging poultry salmonella resistance based on resistance indexes. The invention provides a method for judging the resistance of avian salmonella based on resistance indexes. The resistance indexes comprise the intestinal mucosa layer thickness, the intestinal gland depth, the number of goblet cells in unit length, the ratio of heterophilic granulocytes to lymphocytes and the IFN-gamma concentration. At present, an effective salmonella disease resistance selection index lacks in the poultry breeding field, which is a key point of poultry disease resistance breeding. The salmonella resistance index provided by the invention not only can improve the efficiency and accuracy of disease resistance evaluation, but also provides important theoretical support for salmonella infection resistant breeding. The method fills the blank of poultry salmonella disease resistance selection indexes, and can greatly promote the poultry disease resistance breeding process.
Resumen de: CN120193107A
The invention discloses a salmonella visual detection method of a single-tube nested PCR (Polymerase Chain Reaction) combined CRISPR-Cas12a system, and relates to the field of molecular biology. According to the scheme, the method comprises the following steps: S1, simultaneously amplifying target fragments with different lengths by using two primer pairs aiming at salmonella characteristic genes by adopting a single-tube one-step nested PCR amplification technology; s2, carrying out a reaction on an amplification product obtained in the S1 and a CRISPR-Cas12a system, wherein the system comprises crRNA and a double-labeled reporter probe; and S3, detecting a recognition product obtained in the step S2 through a fluorescence lateral immunochromatography analysis test strip, and realizing visual interpretation through capture of a Biotin mark by streptavidin on a detection line. The abundance of the template is improved while the pollution risk is avoided, and non-target activation is effectively inhibited.
Resumen de: CN120193108A
The invention provides a composition of multiple PCR primers and probes for detecting microorganisms, a kit and a method thereof. The composition comprises 10 pairs of primers and 10 corresponding probes for staphylococcus aureus, salmonella, pseudomonas aeruginosa, clostridium tetani, citrobacter freundii, stenotrophomonas maltophilia, burkholderia cepacia, klebsiella pneumoniae, candida albicans and escherichia coli, the 10 pairs of primers are as shown in SEQ ID No.1-20, and the 10 probes are as shown in SEQ ID No.21-30. The invention further discloses a kit for detecting the staphylococcus aureus, the salmonella, the pseudomonas aeruginosa, the clostridium tetani, the citrobacter freundii, the stenotrophomonas maltophilia, the burkholderia cepacia, the klebsiella pneumoniae, the candida albicans and the escherichia coli. The composition of the primer and the probe is used for detecting microorganisms through multiple PCR, operation is easy and convenient, and the detection accuracy rate is high.
Resumen de: AU2023382983A1
The present invention relates to a DNA construct including: a gene encoding a flagellin protein; and a gene encoding an immunoenhancer (adjuvant) protein. For effective cancer therapy by selectively killing only cancer cells, an attenuated Salmonella strain according to the present disclosure is designed to produce immunogenic substances in cancer tissue to induce a strong anti-cancer immune response, whereby tumor sizes in metastatic cancers as well as primary cancers can be significantly inhibited. Thus, the strain can be advantageously used in a prophylactic or therapeutic composition for improving survival rates.
Resumen de: CN120177776A
The invention relates to the technical field of bacterium detection, in particular to a colorimetric-Raman coding immunochromatography test strip based on a 3D film-shaped SERS probe and a multi-bacterium detection method thereof. According to the technical scheme, the kit comprises a sample pad, a nitrocellulose membrane, a water absorption pad, a 3D membrane-like SERS probe and an operation buffer solution. According to the present invention, the immunochromatography of the 3D film-like probe is provided, the MoDAu-coated Ag SERS nano-film is adopted as the probe in the system, such that the pathogenic bacteria can be highly specifically recognized and captured, the immune complex fluidity can be increased, the rapid quantitative detection of the three pathogenic bacteria can be achieved, and the flexible 3D film-like SERS probe capable of enhancing the colorimetric ability and the SERS activity and highly specifically capturing the pathogenic bacteria can be prepared; by combining with an antibody-modified ICA test strip, rapid, simultaneous and quantitative determination of various pathogenic bacteria is realized.
Resumen de: CN120174154A
The invention relates to the technical field of molecular biological detection, in particular to a primer, a probe group and a kit for multiplex nucleic acid mass spectrometry detection of porcine diarrhea pathogens and application. By adopting a matrix-assisted laser desorption/ionization time-of-flight nucleic acid mass spectrometry technology, eight main pathogens such as PEDV, TGEV, PDCoV, PoRV, SADS-CoV, PBoV, HEV and salmonella can be rapidly, sensitively and specifically detected at the same time. By designing the specific primer and the unexpanded probe and combining multiple PCR amplification and mass spectrometry, the method realizes high-throughput and multi-pathogen simultaneous detection. Experimental results show that the method has high sensitivity and high specificity, has no false positive reaction, and shows 100% repeatability in 60 repeated experiments. Compared with a qPCR method, the detection consistency is as high as 96.2%. The method has the advantages of being easy and convenient to operate, high in detection speed and high in adaptability, can be widely applied to efficient monitoring of porcine diarrhea pathogens, and provides important technical support for early diagnosis, prevention and control of porcine diseases.
Resumen de: CN120177778A
The invention discloses a nano enzyme, a preparation method thereof, a kit and a detection method of the kit. The nano-enzyme comprises a dendritic polymer, a food-borne pathogen aptamer and nano-particles, wherein the food-borne pathogen aptamer and the nano-particles are loaded on the dendritic polymer; the dendritic polymer is a dendritic polymer of which the surface is subjected to RCA reaction, and the surface of the dendritic polymer is provided with a multi-copy repeatedly-serially-connected aptamer chain capable of specifically capturing food-borne pathogens and a multi-copy repeatedly-serially-connected nano-particle repetitive hybridization binding site, wherein the aptamer chain and the multi-copy repeatedly-serially-connected nano-particle repetitive hybridization binding site are in multi-copy repeatedly-serially-connected aptamer chain. According to the kit, due to the quadruple amplification mechanism, the detection signal is remarkably enhanced, the detection sensitivity is improved, the detection range is expanded, and the kit is suitable for detecting the food-borne pathogens in a real sample.
Nº publicación: CN120169352A 20/06/2025
Solicitante:
UNIV GUANGDONG MEDICAL
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Resumen de: CN120169352A
The invention discloses a preparation method of Au (at) Au (at) Ag/Pt/M NPs and application of the Au (at) Au (at) Ag/Pt/M NPs in klebsiella pneumoniae detection, and belongs to the technical field of analysis and detection. The invention particularly relates to development of a signal probe and combination and assembly of the signal probe and lateral flow immunochromatography (LFIA) for klebsiella pneumoniae detection. Au (at) Au (at) Ag/Pt/MNPs is a multi-element noble metal nanoparticle with plasma resonance property, peroxidase-like activity and light stability, shows strong detection potential in three modes of colorimetric (CM), catalytic colorimetric (CL) and surface enhanced Raman scattering (SERS), and is loaded into LFIA to construct a multi-mode LFIA (CM/CL/SERS-LFIA). The kit is expected to be used for direct multimode detection of klebsiella pneumoniae in clinical sputum samples, and a new early detection strategy is provided for respiratory tract infection diseases such as klebsiella pneumoniae.
BOPI
Sede Electrónica
