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95
resultados
Última actualización
03/06/2025 [07:16:00]
Resultados 75 a 95 de 95
Resumen de: CN119614404A
The invention discloses saccharomyces cerevisiae FOSU-QQT as well as a screening method and application thereof, and belongs to the field of microbe application. The saccharomyces cerevisiae FOSU-QQT screened and cultured by the invention does not have hemolytic activity, is gamma hemolysis and has inhibition effects on escherichia coli, salmonella, listeria monocytogenes and staphylococcus aureus, and a strain is prepared into direct vat set freeze-dried powder, so that industrial production is facilitated; saccharomyces cerevisiae FOSU-QQT with strong aroma production is added to brewing of the pineapple peel pomace fruit wine, the aroma production flavor can be obviously improved, the pineapple peel pomace fruit wine has the properties of acid resistance, SO2 resistance, ethanol resistance and the like, and the effect of improving the aroma of the composite fruit wine is facilitated; meanwhile, the saccharomyces cerevisiae FOSU-QQT can also be used for extracting a large amount of nutrient substances in the pineapple peel pomace by a compound fermentation technology with other strains, so that the quality of the fruit wine is improved.
Resumen de: CN119613568A
The invention discloses a chicken infectious anemia virus subunit vaccine, and belongs to the technical field of animal disease vaccines. The invention provides a chicken infectious anemia virus subunit vaccine. Active ingredients of the chicken infectious anemia virus subunit vaccine are recombinant fusion protein of chicken infectious anemia virus VP1 protein B cell epitope and salmonella typhimurium flagellin. The B cell epitope of the chicken infectious anemia virus VP1 protein is obtained by connecting B cell antigen epitopes contained in the chicken infectious anemia virus VP1 protein through a connecting peptide. The salmonella typhimurium flagellin is obtained by deleting a hypervariable region of the salmonella typhimurium flagellin FliC. The fusion expression protein provided by the invention can induce generation of a specific IgG antibody after one-day-old SPF chicken, and after immunization for 28 days, immunized chicken flocks can resist challenge of chicken infectious anemia virus virulent strains, and 70% of challenge chicken flocks are protected without disease attack. The invention has great potential for clinical prevention and control of chicken infectious anemia virus infection.
Resumen de: CN119614725A
The invention discloses a qualitative detection method and a quantitative detection method of salmonella based on RPA-CRISPR/Cas12a (recombinase polymerase amplification-CRISPR/CRISPR/Cas12a). The qualitative detection method comprises the following steps: reacting a mixed system at least comprising an RPA reagent, a salmonella upstream primer, a salmonella downstream primer, a CRISPR/Cas12a system and a to-be-detected sample to obtain a reaction product of the to-be-detected sample; and detecting the reaction product of the to-be-detected sample by adopting a fluorescence detection method or an electrochemical test paper detection method, and qualitatively detecting the salmonella in the to-be-detected sample according to an absorption peak at 500-520nm of a fluorescence spectrum or a T line and a current value of electrochemical test paper. According to the salmonella detection method provided by the invention, potential pollution risks in a traditional step-by-step reaction process are avoided, and meanwhile, the detection method shows high stability, relatively high specificity, excellent sensitivity and excellent field detection capability.
Resumen de: CN119607119A
The invention discloses a pharmaceutical composition, the pharmaceutical composition comprises a traditional Chinese medicine extract and citric acid, the traditional Chinese medicine extract is prepared from the following raw materials in parts by weight: 5-20 parts of fig, 1-30 parts of achyranthes aspera, 1-30 parts of honeysuckle, 1-30 parts of moutan bark, 1-20 parts of blackberry lily, 1-20 parts of radix ophiopogonis, 1-20 parts of adenophora tetraphylla and 1-20 parts of liquorice. The traditional Chinese medicine extract and the citric acid are combined for use, the inhibition effect on escherichia coli, staphylococcus aureus and salmonella is remarkably improved, and acute pharyngitis and chronic pharyngitis can be treated.
Resumen de: CN119607001A
The invention discloses a composition for resisting necrotic enteritis and application thereof, and the composition is prepared from the following components in parts by mass: 5 parts of paeonol, 5 parts of farnesol and 1 part of soybean saponin. The composition can also be prepared into oral liquid, tablets, granules and powder by taking paeonol, farnesol and soyasaponin as effective components and adding auxiliary materials, and the use dosage is 100-1000mg/kg of body weight. Or the composition is directly added into the feed, and the addition amount is 0.1-1% of the total weight of the chicken feed. The composition formed by paeonol, farnesol and soyasaponin is used as a medicine or a feed additive, is high in safety and free of toxic and side effects, can effectively inhibit proliferation of chicken-derived pathogenic bacteria such as clostridium perfringens, salmonella and escherichia coli, effectively improves the antibody titer of a newcastle disease vaccine, and has a good application prospect. And the effects of reducing chicken production performance, increasing proinflammatory cytokines and damaging intestinal absorption and barrier functions caused by chicken coccidiosis and necrotizing enteritis can be relieved.
Resumen de: WO2025054360A1
The disclosure provides for a vaccine depot formulation that comprises a biodegradable thermosensitive hydrogel that has been loaded or embedded with nanoparticles that comprise an antigen and adjuvant, and uses thereof for protecting a subject from an infection or disease.
Resumen de: AU2023312737A1
Provided herein are vaccine composition comprising a
Resumen de: US2025082751A1
The presently-disclosed subject matter relates to antibodies, compositions, and methods for inhibiting and treating virus infection in the respiratory tract and virus transmission through the respiratory tract. In particular, the presently-disclosed subject matter relates to inhibiting and treating virus infection in a subject using compositions and antibodies that trap viruses in mucus of the respiratory tract, thereby inhibiting transport of virus across or through mucus secretions.
Resumen de: US2025084490A1
The invention refers to a method for simultaneous detection and quantification of Listeria monocytogenes, Salmonella spp. and Shiga toxin-producing Escherichia coli (STEC), from any kind of sample related to food production, including complex food matrices such as fish, meat, or fruit; or simple matrices such as water, or food contact surfaces. The method of invention allows specific quantification of the above-mentioned pathogens simultaneously thanks to specificity of designed primers for the qPCR reaction. It is also highly reliable because the method includes a system to adequately control the quantification of pathogens within the matrix. This system comprises the inoculation of samples with a known concentration of a transformed microorganism (host) carrying a chimeric sequence, acting as an internal control host for the whole process.
Resumen de: CN119591671A
The invention belongs to the technical field of biochemistry, and particularly relates to a derived peptide based on frog-derived antibacterial peptide CPF-C1 as well as a preparation method and application of the derived peptide. The general formula of the derivative peptide is as follows: Trp1-Phe2-X3-X4-Leu5-Leu6-X7-X8-Ala9-Leu10-Arg11-Leu12-Trp13-X14-X15-Val16-Leu17-CONH2, X represents lysine, the lysine at the third site, the lysine at the fourth site, the lysine at the seventh site, the lysine at the eighth site, the lysine at the fourteenth site and the lysine at the fifteenth site can be independently selected from alpha-lysine or epsilon-lysine, and the amino acid at the sixth site to the amino acid at the eleventh site can be independently selected from L-type amino acid or D-type amino acid. The derived peptide obtained by the invention has broad-spectrum antibacterial activity, the antibacterial activity on gram-negative bacteria, especially klebsiella pneumoniae, salmonella typhimurium and pseudomonas aeruginosa is obviously higher than that of a parent peptide CPF-C1, and the derived peptide shows relatively low hemolytic activity and relatively good stability; the compound shows a wide application prospect in preparation of clinical antibacterial drugs.
Resumen de: CN119591700A
The invention discloses a nano antibody for resisting salmonella enteritidis, a kit and application of the nano antibody, and belongs to the technical field of genetic engineering. The nano-antibody comprises at least one of the following: A1) a nano-antibody containing amino acid sequences of a complementary determining region CDR1 as shown in SEQ ID NO: 1, a complementary determining region CDR2 as shown in SEQ ID NO: 2 and a complementary determining region CDR3 as shown in SEQ ID NO: 3; a2) a nano-antibody containing a complementary determining region CDR1 shown as SEQ ID NO.6, a complementary determining region CDR2 shown as SEQ ID NO.7 and a complementary determining region CDR3 shown as SEQ ID NO.8. The nano-antibody for resisting salmonella enteritidis provided by the invention is strong in affinity and good in specificity, so that the nano-antibody has a relatively good application prospect in detection of salmonella enteritidis.
Resumen de: CN119592717A
The invention relates to the technical field of infectious disease pathogen detection, and discloses a reagent method for ultra-fast detection of digestive tract infectious disease pathogens, which comprises the following steps: S1, the core of a TaqMan probe method is that a complete probe with free probe molecules cannot detect a fluorescence signal; fluorescence emitted by the luminous group can be absorbed and quenched by the quenching group, the probe is hydrolyzed, and a fluorescence signal can be detected when the luminous group is far away from the quenching group. According to the reagent method for ultrafast detection of the pathogens of the infectious diseases of the digestive tract, a PCR method is combined with a fluorescent probe detection technology, highly conserved sequences of salmonella, vibrio parahaemolyticus and campylobacter jejuni are taken as target regions respectively, specific primers and fluorescent probes are designed, and the three bacteria are detected; the whole process of sampling of a sample to be detected, PCR reaction amplification efficiency and the like is monitored, and then three pathogens and one internal reference are detected at the same time through one reaction hole.
Resumen de: CN119591558A
The invention relates to the field of medicinal chemistry, and particularly discloses an emodin Mannich base as well as a preparation method and application thereof. The emodin Mannich base has a structure as shown in a formula I. The emodin Mannich base is simple in structure and has relatively strong in-vitro antimicrobial activity; the compound has very high inhibitory activity on bacteria such as staphylococcus aureus, bacillus subtilis, micrococcus luteus, escherichia coli, proteusbacillus vulgaris, pseudomonas aeruginosa, shigella dysenteriae and salmonella typhimurium, and fungi such as candida utilis, candida albicans, saccharomyces cerevisiae and monascus purpureus. The compound can be used for preparing antibacterial and/or antifungal drugs. # imgabs0 #
Resumen de: US2025074952A1
Provided is a structure for capturing a compound that includes at least one gene or a product thereof, or a combination thereof among a group of genes involved in the intracellular and extracellular transport function of the compound, the gene or the product thereof being multi-componented.
Resumen de: US2025073282A1
The present invention relates to the technical field of probiotics, in particular to a Lactiplantibacillus plantarum GOLDGUT-LP618 having a function of resisting Salmonella infection and application thereof. The Lactiplantibacillus plantarum GOLDGUT-LP618 provided by the present invention is preserved in China General Microbiological Culture Collection Center, with the preservation number of CGMCC No. 28399. The strain has high resistance to acid and bile salt and can adapt to the digestive tract environment. The strain can inhibit Salmonella infection, relieve diarrhea, inflammation and intestinal damage caused by Salmonella infection, and promote intestinal health. The strain can be used for preparing functional foods, dietary supplements or drugs that can resist Salmonella infection and improve diarrhea and inflammation caused by Salmonella infection, and has good application prospects.
Resumen de: US2025073163A1
The present invention provides a method of treating an infectious disease. The method comprises the step of administering to a subject in need thereof an effective amount of (i) a polymer-flavonoid conjugate, (ii) a flavonoid oligomer, or (iii) micelles having a shell formed by one or more polymer-flavonoid conjugates or one or more flavonoid oligomers, or the combination thereof, and having an agent encapsulated within the shell. The present method is effective to treat viral infection, e.g., severe acute respiratory syndrome coronavirus (SARS-CoV), enterovirus virus, HIV, hepatitis B virus, MERS-CoV, influenza virus, Dengue virus, respiratory syncytial virus, hepatitis C virus, monkeypox virus, human papillomavirus, methicillin-resistant Staphylococcus aureus, Pseudomonas, tuberculosis, Bacillus anthracis, Tetani bacterium, Streptococcus pneumoniae, meningococcus, Escherichia coli, Legionella, Neisseria gonorrhea, Neisseria meningitidis, and Salmonella.
Resumen de: KR20250031183A
본 발명은 표적단백질을 효율적으로 분비할 수 있는 살모넬라 균주 및 이의 제조방법에 관한 것으로, fliD 유전자가 불활성화되어, 플라젤린 단백질의 분비가 증가된 변이 살모넬라 균주를, 표적 단백질과 flgM 단백질의 융합단백질을 암호화하는 유전자를 포함하는 유전자 구조물로 형질전환하여, 표적 단백질과 flgM 단백질의 융합단백질 형태로 표적단백질을 분비하는 것을 특징으로 하는 살모넬라 균주 및 이의 제조방법에 관한 것이다.
Resumen de: KR20250030119A
본 발명은 신규한 살모넬라 엔테리티디스 온도감수성 변이주에 관한 것으로, 본 발명의 변이 균주는 야생형 균주가 번식하는 닭의 정상 체온인 40 내지 45 ℃에서 성장이 억제되어 집락 형성을 억제하므로, 면역화된 무리 내에서 백신 균주가 장기 순환함으로써 치명적인 복귀 돌연변이체가 될 수 있는 위험성이 없는 충분히 약화된 비병원성 백신 균주이며, 닭에서 살모넬라 엔테리티디스에 대항하여 충분한 안전성, 방어 효능 및 면역 반응을 나타냈고, 그에 일치한 표현형 및 유전형 변화도 보였으므로, 이를 온도감수성(온도민감성) 약독화 생균 백신의 유효성분으로 유용하게 사용할 수 있다.
Resumen de: AU2023262222A1
The invention relates to a gelled reaction medium for the detection, identification, enumeration and/or isolation of at least one target microorganism in a sample that may contain same, comprising at least one binding partner specific to a component of a target microorganism or of a component derived from said microorganism, coupled to at least one nanoparticle to form at least one binding conjugate.
Nº publicación: KR20250030535A 05/03/2025
Solicitante:
칠드런즈메디컬센터코포레이션다나파버캔서인스티튜트인크
Resumen de: JP2023175686A
To provide compositions for use in enhancing human immune response and/or as adjuvants in vaccines.SOLUTION: A composition includes an antigen and a specific imidazopyrimidine compound.SELECTED DRAWING: None
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