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97
resultados
Última actualización
31/05/2025 [07:17:00]
Resultados 25 a 50 de 97
Resumen de: WO2023227848A1
The present invention relates to a method for determining the properties of resistance to beta-lactam antibiotics of a strain of enterobacteria present in a biological sample, which method comprises the steps of: a) lysis of the bacteria and hydrolysis of the bacterial proteins in order to obtain a mixture of peptides, b) analysis of this mixture of peptides by targeted mass spectrometry coupled with reverse phase liquid chromatography, detection of at least one specific peptide of an enzyme exhibiting extended spectrum beta-lactamase (ESBL) activity being indicative of the resistance to beta-lactams of the strain of enterobacteria present in the biological sample, the method being characterised in that the analysis step (b) is carried out in the presence of an ion pairing reagent (IPR) added into the chromatography column or into the mixture of peptides.
Resumen de: CN119776251A
本发明公开了一种感应铁镁离子的细菌传感器的构建方法及其应用。本发明属于微生物领域，具体涉及一种感应铁镁离子的细菌传感器的构建方法及其应用。重组大肠杆菌含有超折叠绿色荧光蛋白sfGFP编码基因、感应蛋白PmrB突变体编码基因和响应调节蛋白PmrA突变体编码基因、信号传导蛋白PmrD编码基因和强核糖体结合位点RBS，并含有通过调节蛋白PmrA激活的磷酸化酶PmrG的启动子驱动的T7 RNA聚合酶编码基因和T7启动子驱动的sfGFP编码基因，同时过表达磷酸乙醇胺转移酶EptA编码基因。本发明构建了检测铁离子浓度的细菌传感器，并可通过铁镁离子的诱导改变细菌传感器的脂多糖的修饰，增强细菌的耐药性。
Resumen de: CN119752748A
本发明属于兽医生物制品领域，具体涉及一株驴源马流产沙门菌crp基因缺失株YZUSAL01Δcrp及其构建方法和应用。本发明的基因缺失株已保藏于中国典型培养物保藏中心，保藏号为CCTCC NO:M 20241741。该缺失株是利用λ‑Red同源重组技术，将马流产沙门菌的crp基因敲除后获得的。本发明制备的基因缺失株毒力显著下降，具有良好的安全性。对小鼠的攻毒免疫保护效果良好，为马流产沙门菌减毒活疫苗奠定基础。
Resumen de: US2025110128A1
A method for detecting biological objects by means of an SPR imaging detection system comprising an optical measurement device configured to generate plasmon resonance on a functionalized surface when said surface is exposed to a gas; the method comprising: an assimilation step by exposing the functionalized surface to a sample of interest formed of an aqueous carrier liquid containing the biological objects; a step of removing the liquid in contact with the functionalized surface and exposing the surface to a gas not containing the biological objects, said objects remaining bound to the ligands of the sensitive site of the functionalized surface; a step of acquiring an image of the sensitive site; a step of detecting the biological objects from the acquired image.
Resumen de: US2025109447A1
The present invention relates to a CRISPR-Cas based composition for detecting Salmonella and a method for detecting Salmonella using the same, more specifically, to a composition for detecting Salmonella comprising primers capable of specifically amplifying Salmonella through isothermal amplification, guide RNA, and CRISPR-Cas proteins, and a method for detecting Salmonella using the same.
Resumen de: AU2023323947A1
The invention is directed to immunogenic compositions and method of treatment comprising a peptide or nucleic acid that encodes the peptide that induces an immune response in a mammal that is protective against infection by one or more pathogens. The peptide sequence contains multiple epitopes, wherein at least one epitope is a composite epitope which is a combination of two or more conserved epitopes of the pathogen wherein the amino acid sequence of the composite is not an amino acid sequence of the pathogen. In addition, the invention is directed to vaccines comprising the peptide or nucleic acid that encodes the peptide for treating and preventing an infection in mammals such as animals and humans.
Resumen de: CN119736221A
本发明公开了一种表达Bcf菌毛的重组菌株，重组菌株由将含有Bcf操纵子基因的表达载体导入惰性载体菌中得到。将Bcf操纵子基因插入到表达载体pBR322中得到重组质粒，将所述重组质粒导入惰性载体菌S9中得到所述重组菌株，惰性载体菌S9的保藏编号为CGMCC No.17340。上述重组菌株在快速、特异性、敏感性、稳定性、简单和价廉等方面表现更好，能够满足畜禽群的沙门氏菌感染现场和大规模、大批量、快速检测的要求，通过靶向检测多种血清型沙门氏菌感染，适用于沙门氏菌的大规模初筛工作。还能够对沙门氏菌疫苗接种后抗体水平进行监测。
Resumen de: WO2025063348A1
The present invention relates to a novel bacteriophage having specific killing ability against Salmonella enterica and an antibacterial composition comprising same, wherein the composition comprising the bacteriophage as an active ingredient can be usefully employed as a composition for preventing or treating infectious diseases caused by Salmonella enterica, feed for livestock, drinking water, a cleaning agent, and a disinfectant.
Resumen de: CN119709659A
The invention discloses a conserved B cell epitope peptide of a riemerella anatipestifer (RA) surface adhesion factor 3-phosphoglyceraldehyde dehydrogenase (GAPDH), a nucleic acid molecule, a recombinant vector and an application of the conserved B cell epitope peptide. Conservative B cell epitope TG12 is inserted into Salmonella pullorum Peg pili, inert carrier bacteria are introduced, and recombinant bacteria capable of functionally expressing and displaying RaGAPDH protein surface conservative B cell epitope peptide are obtained. The conserved B cell epitope expressed and exhibited can specifically recognize and bind duck-derived and goose-derived RA-infected serum, and macroscopic agglutination reaction particles are observed and have no cross agglutination reaction with other pathogen-infected positive serum. The agglutination detection method has the advantages of specificity, convenience and the like, and is expected to provide a new thought and method for detection, prevention and control of RA infection.
Resumen de: CN116121203A
The invention discloses a clostridium welchii bacteriophage PM11, a bacteriophage composition and application of the clostridium welchii bacteriophage PM11, the clostridium welchii bacteriophage PM11 is used for preventing and controlling poultry bacterial diarrhea, the preservation number of the clostridium welchii bacteriophage PM11 is CGMCC No.22372, and the clostridium welchii bacteriophage PM11 is preserved in the China General Microbiological Culture Collection Center on April 12, 2021 and has the preservation number of CGMCC The invention also discloses a bacteriophage composition formed by compounding the clostridium welchii bacteriophage PM11, an escherichia coli bacteriophage PD205 and a salmonella bacteriophage PC192, and the clostridium welchii bacteriophage and the bacteriophage composition can be used as active ingredients for effectively preventing and treating avian bacterial diarrhea, and can also be used as an environment disinfectant. And compared with a single lytic bacteriophage, the bacteriophage has the characteristic of wide lysis spectrum, widens the sterilization range and improves the sterilization activity.
Resumen de: CN119709330A
The invention belongs to the technical field of cleaning of poultry eggs, and discloses a special cleaning agent for poultry eggs as well as a preparation method and application thereof. The special cleaning agent for poultry eggs comprises the following components: linear alkylbenzene sulfonate, fatty alcohol polyoxyethylene ether sodium sulfate, cocoanut fatty acid diethanolamide, sodium silicate, sodium tripolyphosphate, sodium carbonate, sodium chloride, sodium hypochlorite, a defoaming agent, an enzyme preparation and water. The cleaning agent is used for cleaning fresh poultry eggs, dirt on the surfaces of the poultry eggs can be rapidly removed, the dirt can be prevented from being adhered again, the sterilization rate on escherichia coli, staphylococcus aureus and salmonella reaches 95% or above, meanwhile, the influence on the strength of the poultry eggs can be reduced to the maximum extent, and the breakage rate of the poultry eggs is kept at the low level.
Resumen de: CN119700725A
The invention discloses an application of methyl catechol in preparation of a medicine for inhibiting salmonella typhimurium, and the methyl catechol is 3-methyl catechol or 4-methyl catechol. 3-methylcatechol or 4-methylcatechol can be used for reducing the adhesion and invasion ability of salmonella typhimurium to human colorectal epithelial cells NCM460 and inhibiting the virulence of salmonella typhimurium.
Resumen de: CN119716048A
The invention discloses a salmonella infection marker and application thereof. By constructing a salmonella challenge model and combining a proteomics technology, it is successfully identified that ZNF143 can be used as a potential protein marker of salmonella infection, so that a more direct, rapid and accurate salmonella detection approach is provided, and a solid theoretical foundation is laid for developing a novel, efficient and accurate salmonella detection technology.
Resumen de: WO2025063348A1
The present invention relates to a novel bacteriophage having specific killing ability against Salmonella enterica and an antibacterial composition comprising same, wherein the composition comprising the bacteriophage as an active ingredient can be usefully employed as a composition for preventing or treating infectious diseases caused by Salmonella enterica, feed for livestock, drinking water, a cleaning agent, and a disinfectant.
Resumen de: AU2023346467A1
The present invention relates to a modified live attenuated strain of Salmonella, said strain comprising at least one chromosomally integrated synthetic polynucleotide sequence inserted into a pre-determined pseudogenomic location, said sequence comprising at least one defined recombination site for the introduction of a heterologous polynucleotide sequence encoding a polypeptide, wherein said chromosomally integrated synthetic polynucleotide sequence is located within at least one genomic locus as defined by any one of SEQ ID NOs: 1-30, or a sequence comprising at least 70% identity to any one of SEQ ID NOs: 1-30. The present invention also relates to a vaccine composition comprising the modified strain and various uses and methods thereof.
Resumen de: AU2023361317A1
The present invention relates to a modified live attenuated Gram-negative bacteria, wherein said bacteria has been modified in such a way that RNA molecules can be safely and efficiently delivered to target eukaryotic cells. As such, the present invention relates a to a bacterial delivery system and various uses and methods thereof.
Resumen de: US2025099564A1
A vaccine for treating Salmonella enteriditis that includes an immunogenically effective amount of a Salmonella enteritidis protein InvG, and optionally a pharmaceutically acceptable carrier is described. Methods of using compositions that include the Salmonella Enteritidis protein InvG or a delivery vector that expresses Salmonella Enteritidis protein InvG for immunizing poultry against Salmonella Enteritidis are also described.
Resumen de: WO2025060396A1
A probiotic and prebiotic composition and the use thereof. The composition comprises human milk oligosaccharides, Bifidobacterium bifidum and Bifidobacterium longum subsp. infantis, and has the advantages of improving the resistance of gastrointestinal tracts to pathogenic bacterial infection and reducing colonization of Salmonella.
Resumen de: KR20250041982A
본 발명은 비장티푸스성 살모넬라 2가 백신의 면역원성 동시 측정용 혈청사멸분석법에 관한 것이다.
Resumen de: WO2023223331A1
The present invention relates to diagnostic platform. More specifically, the invention relates to a dual platform composed of a detection and quantification unit and a characterization unit, systems, kits, methods and uses thereof in detection, quantification and characterization of pathogens, the system comprising monoclonal-antibody-based biosensor chips, for detection and/or quantification of pathogens in a sample, and substrate-based biosensor chips for enzymatically profiling the pathogen in the sample.
Resumen de: CN119679780A
The invention discloses application of a licoflavone compound in resisting food-borne pathogenic bacteria and dairy cow mastitis pathogenic bacteria. The licoflavone compound has the advantages that the licoflavone compound can be used for treating food-borne bacterial diseases caused by food-borne bacteria such as escherichia coli, bacillus cereus, listeria monocytogenes and salmonella enteritidis; food-borne fungal diseases caused by food-borne fungi such as aspergillus flavus, penicillium expansum and monilinia coerulea; the licochalcone A shows certain inhibitory activity on dairy cow mastitis pathogenic bacteria caused by streptococcus agalactiae, streptococcus dysgalactiae, escherichia coli and staphylococcus aureus, and particularly has an obvious inhibitory effect on food-borne pathogenic bacteria and dairy cow mastitis pathogenic bacteria by three licochalcone A with different contents. The compound disclosed by the invention is simple in structure and relatively high in safety, and is expected to be developed into a novel antibacterial drug.
Resumen de: CN119679832A
The invention belongs to the technical field of microorganisms, and particularly relates to application of selenium-enriched lactobacillus reuteri to prevention and treatment of enteropathogenic bacteria infection and promotion of chick growth. The selenium-enriched lactobacillus reuteri is obtained by carrying out selenium-enriched culture on lactobacillus reuteri with the preservation number of CGMCC (China General Microbiological Culture Collection Center) No.31975, and the selenium-enriched culture is that the lactobacillus reuteri is placed in a culture medium with the sodium selenite content of 5 to 7mg/mL for culture. The enteropathogenic bacteria comprise vibrio parahaemolyticus, escherichia coli, vibrio cholerae and salmonella typhimurium, and the selenium-enriched lactobacillus reuteri obtained after selenium-enriched culture is stronger in biological function, can remarkably promote growth of chickens, can effectively inhibit growth of pathogenic bacteria, reduces the bacterial infection risk of chicken flocks, improves the breeding benefit, and has a good application prospect. A brand-new, safe and effective solution is provided for the poultry breeding industry.
Resumen de: CN119685325A
The invention discloses a preparation method of a triangular multivalent aptamer initiation chain with magnetic nanoparticles, and particularly relates to the field of salmonella detection.The method comprises the steps that all DNA sequences are dissolved with a 1 * TMS buffer solution, and the final concentration is 50 mu M; the method comprises the following steps: adding Apt1, Apt2, Tri, Linker and an initiation chain into a 1 * TMS buffer solution to obtain a mixed solution; heating the mixed solution to 95 DEG C to react for 4 minutes, then quickly cooling to 4 DEG C, and keeping the solution at 4 DEG C for 1 minute to prepare a multivalent aptamer initiation chain crude product in a triangular structure state; carrying out ultrafiltration on the multivalent aptamer initiation chain crude product to remove free chains, so as to obtain a multivalent aptamer initiation chain marked as Tri-MAI; and washing the streptavidin-coupled nano magnetic beads with PBS (Phosphate Buffer Solution), then carrying out resuspension in a Tri-MAI solution, and incubating at room temperature for 0.5 h to obtain a triangular multivalent aptamer initiation chain with magnetic nanoparticles, which is recorded as MTAI. When the triangular multivalent aptamer initiation chain is used for detecting salmonella in a sample, the triangular multivalent aptamer initiation chain has the advantages of sensitivity, rapidness and simplicity.
Resumen de: CN119684445A
The invention relates to the technical field of biological detection, in particular to a Brucella lipopolysaccharide-resistant monoclonal antibody with a competitive effect and application of the Brucella lipopolysaccharide-resistant monoclonal antibody. The monoclonal antibody can be subjected to specific reaction with Brucella melitensis, Brucella bovis and Brucella suis, and is not subjected to specific reaction with Escherichia coli, salmonella and Yersinia enterocolitica. The positive serum of the Brucella antibody of cattle and sheep has an inhibiting effect on the combination of the monoclonal antibody and Brucella lipopolysaccharide, and can be used for establishing a Brucella antibody competitive ELISA (enzyme-linked immuno sorbent assay) detection method. The monoclonal antibody for resisting brucella lipopolysaccharide and the application of the monoclonal antibody provide solid material and technical support for the development of the detection technology of brucellosis in China.
Nº publicación: CN119685501A 25/03/2025
Solicitante:
GUANGZHOU LIDEMAN MEDICAL TECH CO LTD
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Resumen de: CN119685501A
The invention discloses a detection method for detecting enteropathogenic bacteria, and relates to the field of molecular biology, specific genes are searched in genomes of salmonella, shigella, vibrio parahaemolyticus, campylobacter jejuni, diarrheagenic escherichia coli, vibrio cholerae and staphylococcus aureus, a beta-actin gene is adopted as a reference gene, and the enteropathogenic bacteria are detected. Primer and probe sequences are designed, a probe group consisting of the primer and probe sequences is used for carrying out real-time fluorescent PCR amplification reaction on nucleic acid in a detected sample, then melting curve analysis is carried out, and whether the pathogenic bacteria exist in the nucleic acid sequence to be detected or not can be judged according to a Tm value. The detection method provided by the invention has the advantages of rapidness, high throughput, accuracy and high sensitivity.
BOPI
Sede Electrónica
