Absstract of: US2024277582A1
The present invention relates to free-radically polymerizable compositions for 3D printing of dental crowns, bridges, prosthetic teeth or full prostheses which on account of their filler combination feature very good mechanical properties and optimal sedimentation stability.
Absstract of: US2024277378A1
The present invention provides methods of forming flexible implant devices and U-bridge implants that drive into curved trajectories to enhance implant fixation in bone. The curved drilling trajectories avoid regions of low bone mineral density, such that flexible implants and/or U-bridge implants driven into the curved drilling trajectories are anchored in regions of high bone mineral density to improve the stability of bone fixation. The flexible implants and U-bridge implants are suitable for several applications, including but not limited to spinal fixation, orthopedic bone fixation, and neurosurgery.
Absstract of: US2024279617A1
Assay and systems are provided that include use of cells and/or organoid for patient diagnosis, drug development, and personalized medicine, including for diagnosis and treatment of cancer and associated diseases and disorders. In one aspect, systems and methods include applying a phase-specific and force-guided polymerization of a biomaterial, wherein the polymerization comprises a nucleation phase and an elongation phase; thereby, producing a model.
Absstract of: US2024279374A1
A photocurable resin composition, the photocurable resin composition comprises a photoinitiator, optionally an oligomer comprising at least one alkene moiety (which may be a 1,2-disubstitued moiety, or an acrylate moiety), and a drug-derived monomer (1, 2, 3, 4, 5) having at least one photo-crosslinkable moiety which may be an alkene moiety).
Absstract of: WO2024170242A1
Disclosed is a computer-implemented method for closing one or more holes in a bottom section of a three-dimensional digital preparation model of a preparation of a tooth. The tooth is prepared for receiving a dental restoration element with a lower limit of the bottom section of the preparation being prepared in form of a stepless edge. The method comprises receiving the three-dimensional digital preparation model of the prepared tooth. One or more holes of the three-dimensional digital preparation model to be closed are detected within the bottom section. A preparation angle used for preparing the bottom section is determined and the detected one or more holes are closed. The closing comprises an extrapolation of the bottom section into the holes using the determined preparation angle.
Absstract of: WO2024173543A2
The present disclosure provides monomer compounds that can produce desirable polymeric materials and photo-curable resins. Further provided herein are methods of producing compounds, compositions, resins, devices, and polymeric materials. Also provided herein are methods of using compounds, resins, and polymeric materials for the fabrication (e.g., via 3D printing) of medical devices, such as orthodontic appliances.
Absstract of: WO2024173708A1
The present disclosure provides compounds capable of producing biradical photoinitiators (e.g., cyclic photoinitiators), photo-curable resins produced using one or more biradical photoinitiators, as well as polymeric materials formed using the biradical photoinitiators. Further provided herein are methods of producing the compositions and using the same for the fabrication (e.g., via 3D printing) of medical devices, such as orthodontic appliances.
Absstract of: DE102023103800A1
Die vorliegende Erfindung betrifft radikalisch polymerisierbare Zusammensetzungen zum 3D-Druck von dentalen Kronen, Brücken, Prothesenzähnen oder Vollprothesen, die sich aufgrund ihrer Füllstoffkombination durch sehr gute mechanische Eigenschaften und eine optimale Sedimentationsstabilität auszeichnen.
Absstract of: WO2024171132A1
The present invention relates to a complex additively manufactured structure (100) used as an implant for orthopedic applications. The complex additively manufactured structure (100) comprises a first lattice structure (102) comprising a plurality of interconnected first unit cells (102a) arranged in three-dimensions. The complex additively manufactured structure (100) also comprises a second lattice structure (104) comprising a plurality of interconnected second unit cells (104a) arranged in three-dimensions. The first lattice structure (102) is concentric to the second lattice structure (104). The first lattice structure (102) comprises a gyroid architecture. The second lattice structure (104) comprises a 3D Voronoi tessellation.
Absstract of: WO2024172411A1
The purpose of the present disclosure is to provide a patient-customized helmet and a control method therefor, the helmet enabling the injection of an ultrasound contrast agent (e.g., microbubbles) into blood vessels of a patient and the radiation of ultrasonic waves into the brain by means of an ultrasound module to open the blood-brain barrier and deliver a brain disease therapeutic agent to the affected area.
Absstract of: EP4417179A1
Die vorliegende Erfindung betrifft radikalisch polymerisierbare Zusammensetzungen zum 3D-Druck von dentalen Kronen, Brücken, Prothesenzähnen oder Vollprothesen, die sich aufgrund ihrer Füllstoffkombination durch sehr gute mechanische Eigenschaften und eine optimale Sedimentationsstabilität auszeichnen.
Absstract of: EP4417195A1
The invention provides an excipient composition for the preparation of an amorphous solid dispersion or amorphous solid solution suitable for, i.a., 3D printing of immediate release tablets. The excipient composition comprises:a) 8-20 % by weight of the excipient composition of sugar alcohol, andb) 80-92 % by weight of the excipient composition of a polymer blend, the polymer blend comprising a first polymer component and a second polymer component in a weight ratio of 1:0.55 - 1:1.75, the first polymer component being a copolymer of 1-vinyl-2-pyrrolidone and vinyl acetate, and the second polymer component being polyethylene glycol-polyvinyl alcohol graft copolymer.
Absstract of: CN117794667A
A method of manufacturing an implantable device includes directing a projection of laser energy having a plurality of adjacent energy pixels onto a build surface atop a powder bed, thereby forming a layer of the implantable device. The guiding step is repeated a plurality of times in a layer-by-layer manner such that the entirety of the layers formed defines at least a portion of the implantable device.
Absstract of: US2023381478A1
A microneedle array is provided for administrating a drug or other substance into a biological tissue. The array includes a base substrate; a primary funnel portion extending from one side of the base substrate; and two or more solid microneedles extending from the primary funnel portion, wherein the two or more microneedles comprise the substance of interest. Methods for making an array of microneedles are also provided. The method may include providing a non-porous and gas-permeable mold having a two or more cavities each of which defines a microneedle; filling the cavities with a fluid material which includes a substance of interest and a liquid vehicle; drying the fluid material to remove at least a portion of the liquid vehicle and form a plurality of microneedles that include the substance of interest, wherein the filling is conducted with a pressure differential applied between opposed surfaces of the mold.
Absstract of: EP4417685A1
The present invention relates a bioprinted three-dimensional tumor model which is able to reproduce the cellular heterogeneity, the spatial architecture, and the tissue-specific ECM of the tumor microenvironment. In addition, the invention refers to a process for preparing such three-dimensional tumor model, to methods for testing anticancer drugs as well as to the use of the tumor model in developing personalized medicine and developing new therapies based on the understanding of the in vitro tumor progression.
Absstract of: US12064355B1
Spinal interbody fusion implants for use in posterior lumbar interbody fusions (PLIF), anterior lumbar interbody fusions (ALIF), transforaminal lumbar interbody fusions (TLIF) and transpsoas interbody fusions (DLIF), each of the implants including a 3-D printed titanium frame having meshed sidewalls, open top and bottom faces and a selectively closeable back plate for enclosing a posterior end of the frame. A machined, acid treated allograft bone graft is contained within the frame, the bone graft having a window for containing a biomaterial, anti-migration teeth and a ridge configured to mate with a slot within the frame for locking the graft in the frame.
Absstract of: CN118512650A
本申请属于生物再生医学领域,具体涉及一种光固化3D打印的仿生皮肤水凝胶支架及其制备方法。本申请通过精密的原料配方设计与优化的3D打印工艺参数调控,成功研制出生物相容性卓越的水凝胶仿生皮肤支架。此支架不仅具备高度的生物相容性和类似真实组织的物理特性,还展现了对细胞代谢与伤口愈合的强大促进作用,为受损组织提供了既温和又稳固的支持平台,显著优于传统无机材料支架,极大降低了植入后的排斥反应和并发症风险,增强了患者的舒适度与治疗配合度。
Absstract of: CN118514329A
本发明涉及牙模处理技术领域,具体为一种牙模高效节能处理机,包括壳体,壳体内分别设置有牙模脱水装置和牙模清洗装置,壳体顶部设置有两个可翻起的第一盖板件和第二盖板件,本发明将牙模脱水装置和牙模清洗装置集成在同一台设备内,使得牙模在一台设备内能够同时进行脱水和清洗处理,提高了牙模的处理效率;并且对牙模进行脱水处理时,可以通过转动驱动件能够带动离心脱水桶转动,从而使离心脱水桶内的3D打印液甩出,提高牙模的脱水效率,而在牙模清洗时采用气泵和鼓泡的结构,使得在牙模清洗时,清洗液内部能够产生液体流动和气泡,以此对牙模进行清洗,并且整个清洗过程中不会产生温度的升高,从而避免了清洗液因为温度升高而产生挥发的问题。
Absstract of: CN118514328A
本发明公开了一种无托槽隐形正畸矫治器的柔性加工设备,涉及矫治器加工技术领域,旨在解决现有的正畸矫治器加工设备难以保障资源的利用率,且容易在加工过程中影响正畸矫治器的加工精度的技术问题,包括机体外壳、设置在机体外壳内的打印器、门板、机体底座和平台组件。本发明一方面可以通过加热的方式保持该装置内部的温度,且在保持温度的同时可以通过安装组件加强该装置与地面的吸附效果,提高该装置使用时的稳定性,保障该装置加工模型的精度,另一方面,在使用完毕后该装置可以通过回收热气以及加速排放冷气的方式提高该装置内部的散热效率,提高了该装置的能源利用率。
Absstract of: CA3242084A1
The present invention relates to an additive manufacturing apparatus (1) for additively manufacturing a component (2) comprising: a resin vat unit (3) which comprises: a reservoir (4) for storing UV-light photocurable resin (5); and a frame assembly (6) holding a UV-transparent window (6-4) at the bottom of the reservoir (4), wherein said UV-transparent window (6-4) includes a UV-transparent plate (6-4a) and a UV-transparent anti-adhesive flexible foil (6-4b); a projection unit (7) for projecting UV-light (8) through the UV-transparent window (6-4) into the reservoir (4); a movable building platform (9) having a surface (9a) onto which said component (2) can be formed through layerwise curing of said resin (5); characterized in that the UV-transparent window (6-4) further includes a removable frame-like spacer foil (6-4c) which has a predetermined thickness and can be removably mounted by means of the frame assembly (6) between the UV-transparent plate (6-4a) and the UV-transparent anti-adhesive flexible foil (6-4b) in order to create a plate-foil air gap (6-4d); and at least one air hole (6-2a) for communicating said plate-foil air gap (6-4d) with the atmosphere.
Absstract of: US2024262115A1
Provided is a recording device including a medium support portion that supports a medium, a recording unit that performs recording on the medium, an irradiation unit that emits an ultraviolet ray toward the medium, a deodorization portion that performs deodorization, and a housing that accommodates the medium support portion, the recording unit, the irradiation unit, and the deodorization portion, in which the deodorization portion includes a deodorization body, a deodorization body cover that covers the deodorization body, and an accommodation portion that accommodates the deodorization body covered by the deodorization body cover, and the deodorization body is configured to be taken out from the accommodation portion together with the deodorization body cover.
Absstract of: CN118512656A
本发明属于生物材料及其制备技术领域,提供了一种纳米颗粒梯度分布的组织修复材料及其制备方法。所述组织修复材料由光固化水凝胶、3D支架以及带电纳米颗粒组成,所述3D支架具有相互贯通的多孔结构,并且3D支架的孔隙尺寸大于带电纳米颗粒的尺寸,所述光固化水凝胶包裹3D支架并充满3D支架的孔隙,所述带电纳米颗粒梯度分布于光固化水凝胶中。本发明还提供了上述组织修复材料的方法,基于电场调控实现了带电纳米颗粒材料的梯度分布,并通过光交联将在电场下形成带电纳米颗粒的梯度分布结构快速固定。本发明可更好地仿生机体组织的天然梯度结构,降低了制备方法对功能纳米材料性能的要求,并拓展了方法对功能纳米材料的普适性。
Absstract of: CN118515822A
本发明公开了一种耐磨高刚性齿科3D打印用光敏树脂及制备方法。一种耐磨高刚性齿科3D打印用光敏树脂按照重量份包括A混合物400‑475份和B混合物25‑100份;其中,A混合物按照重量份包括聚碳型丙烯酸酯75‑100份、聚氨酯丙烯酸50‑75份、丙烯酰吗啉150份、三(2‑羟乙基)异氰脲酸三丙烯酸酯100‑110份、三环癸烷二甲醇二丙烯酸酯75份、TPO 15‑25份;B混合物按照自身重量份比包括耐磨剂40%和助剂60%,耐磨剂为核壳结构,核为二氧化硅,壳为聚丙烯酸酯;助剂为纳米氧化铝浆液。制备方法为分别制备A混合物和B混合物,取A混合物425g,B混合物75g于1L容器内搅拌制备产品。本发明极大提高了齿科类光敏树脂在耐磨性、刚性及韧性方面的性能。
Absstract of: CN118512658A
本发明公开了一种脱细胞基质编织材料及制备方法与应用,属于生物材料技术领域,该脱细胞基质编织材料利用3D打印结合编织方法制备得到。本发明同时公开了上述制备方法制备得到的脱细胞基质编织材料及其在制备组织工程支架材料中的应用。本发明利用3D打印技术辅助编织,可以实现脱细胞基质纤维编织材料宏观和微观结构的精细化控制,可制备不同形状的支架材料,用于多种组织修复,促进组织内源性再生。
Nº publicación: CN118524923A 20/08/2024
Applicant:
登士柏希罗纳有限公司希罗纳牙科系统有限公司
Absstract of: CA3241100A1
The present invention relates to an additive manufacturing apparatus (1) for additively manufacturing a component (2), comprising: a resin vat unit (3) which comprises: a reservoir (4) for storing UV light photocurable resin (5); and a UV-transparent window (6-4) at the bottom of the reservoir (4), wherein said UV-transparent window (6-4) includes a UV-1 transparent plate (6-4a) and a UV-transparent anti-adhesive flexible foil (6-4b); a projection unit (7) for projecting UV light (8) through the UV-transparent window (6-4) into the reservoir (4); a movable building platform (9) having a surface (9a) onto which said component (2) can be formed through layerwise curing of said resin (5). The UV-transparent window (6-4) further comprises: an optical means (6-5) which is adapted to diffuse the projected UV light (8) towards the building platform (9) into a region (R) where the UV light photocurable resin (5) is to be layerwise cured, wherein the optical means (6-5) is arranged in the light path of the projected UV light (8).