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167
results.
Updated on
01/09/2024 [07:36:00]
Results 25 to 50 of 167
Absstract of: CN118526634A
本发明涉及生物材料及3D打印技术，特别是涉及一种用于骨组织工程的复合支架及其制备方法。其主要由聚乳酸、锶离子掺杂的矿化胶原按以下重量份比制成：8~12∶85~95。矿化胶原是矿物与胶原分子受控组装成周期排列结构。本发明由于通过矿化胶原和锶离子掺杂的矿化胶原制成，其具有理想的力学性能，而且还应提供良好的成骨活性来调节细胞反应和促进骨组织修复。
Absstract of: CN118530021A
本发明涉及正畸托槽技术领域，且公开了一种抗菌纳米颗粒喷射生产的氧化锆托槽与制备方法，包括具有粘结面微结构的氧化锆托槽，所述氧化锆托槽的底部的粘结面微结构呈圆形凹台或各种凸台形状。本发明通过纳米颗粒喷射3D打印技术制造的氧化锆托槽，只需要在计算机辅助设计软件中对托槽进行设计并生成STL模型，即可投入生产，通过配置纳米氧化锆粒子，纳米氟化钙粒子的复合材料墨水，使氧化锆托槽含有抗菌性能，具有防止牙齿齲坏的效果，且制备过程中不会产生有毒有害物质，且表面后处理使用振动抛光方式，自动化、去人化、批量化功能。
Absstract of: CN118526637A
本发明属于组织修复材料领域，公开了一种具有过氧化氢调控功能的3D打印生物墨水、凝胶及其制备方法与应用；该3D打印生物墨水由以下原料于水相缓冲溶液中混合得到：儿茶酚改性明胶甲基丙烯酸酯GD：10‑20w/v％；聚乙二醇二丙烯酸酯PEGDA：5‑10w/v％；光引发剂：0.25‑1w/v％；阻光剂：0.025‑0.1w/v％。本发明所提供的3D打印生物墨水，不仅具有可打印性，还能够实现再生理环境下至少长达1个月的时间内的持续H2O2缓释效果；同时GD‑P水凝胶在植入初期具有降低环境H2O2的效果；因此，该3D打印生物墨水实现了环境H2O2的双向调控功能。
Absstract of: FR3145859A1
Instrument comprenant : une pince (1) avec une extrémité active (1d) et un fourreau (2) recevant la pince (1) à coulissement un corps central (3) avec une première extrémité proximale (3p) solidaire d’un manche (4) et une deuxième extrémité distale (3d) à laquelle est fixée une première extrémité de la pince (1p), opposée à l’extrémité active (1d) de ladite pince (1), un actionneur(5) formé d’un ensemble de leviers (6) s’étendant autour du corps central (3) et ayant des premières extrémités (6p) reliées au corps central (3) et des deuxièmes extrémités (6d) réunies par une douille (7) à laquelle est fixée le fourreau (2), les leviers (6) étant élastiquement déformables entre une première position désactivée de la pince (1) dans laquelle l’extrémité active (1d) de la pince (1) est ouverte et en saillie du fourreau (2) et une deuxième position activée dans laquelle le fourreau (2) vient exercer un effort sur l’extrémité active (1d) de la pince (1) en forçant la fermeture de l’extrémité active (1d) de la pince (1) dans lequel le corps central (3), l’actionneur (5) et la douille (7) sont une pièce monobloc. FIGURE DE L’ABREGE : Fig. 1
Absstract of: WO2024172769A1
The invention relates to an implant material that has enhanced bioactivity compared to known polyether ether ketone (PEEK) and PEEK/hydroxyapatite (HA) materials that are available in the market. It discloses a biocomposite material comprising of 65-80% by weight of PEEK, 15-30% by weight of HA and 4.5-5.5% by weight of silicates such as magnesium silicate. It further discloses a method for obtaining a 3D-printable biocomposite material. This material enhances cell proliferation rate, and enhances osseointegration at the implant-tissue interface. This material exhibits comparable imaging compatibility to that of known PEEK-based materials Additionally, this material causes less radiation scatter during radiation delivery compared to metallic materials, thereby facilitating improved treatment planning.
Absstract of: WO2024172770A1
The present disclosure relates to a method of preparing a printable wax with an improved viscosity for use in 3D printing in dentistry. The method comprises heating a dental wax, adding a copolymer or a surface modified nano filler to the dental wax in an effective amount to tune the flow viscosity of the dental wax to a desired viscosity while the dental wax is still heated; subjecting the dental wax to vigorous stirring to disperse the copolymer or the surface modified nano filler well in the dental wax; and allowing the dental wax to cool down, resulting in a printable wax with improved viscosity for fast 3D printing.
Absstract of: WO2024169746A1
The present invention relates to the technical field of biomedical metal materials, and specifically disclosed are a medical tantalum alloy that is light, low-cost, low-modulus and high-strength, having excellent machining performance and excellent biocompatibility. The medical tantalum alloy comprises the following components by mass percentage: 15-75% tantalum, 0-23% niobium, 0-18% zirconium, 0-1% copper, ≤0.01% hydrogen, ≤0.15% oxygen, ≤0.1% carbon, ≤0.05% nitrogen, ≤0.2% iron, ≤0.05% tungsten, ≤0.03% molybdenum, ≤0.08% silicon, and ≤0.03% nickel, the balance being titanium. Also disclosed is a method for preparing the medical tantalum alloy. The method comprises using additive manufacturing or powder metallurgy in-situ alloying, or high-temperature melting or gas-phase reaction pre-alloying. The medical tantalum alloy is lightweight, high-strength, low-cost, and low-modulus, and has excellent machining performance and excellent biocompatibility, and is suitable for manufacturing implantable devices in the fields of orthopedics, craniomaxillofacial, oral cavities, etc.
Absstract of: WO2024171181A1
A method for reinforcing a cellularized retinal construct fabricated from (i) endothelial cells; (ii) retinal pigment epithelial cells and/or photoreceptors; and (iii) an extracellular matrix (ECM) hydrogel is disclosed. The method comprises contacting the construct with a biocompatible small-molecule reinforcing agent that is capable of chemically interacting with the ECM hydrogel under conditions that maintain viability of the cells, to thereby increase a compressive modulus of the ECM hydrogel by at least 10 %.
Absstract of: WO2024173885A1
Techniques for deep tissue in vivo printing are described. Some implementations of the disclosure relate to a method that includes: obtaining a biopolymer mixture including prepolymer material and a crosslinking agent encapsulated in carrier particles; delivering the biopolymer mixture to a subcutaneous or deep tissue target location of a subject; and transmitting with a bioprinting device, via transcutaneous application, radiation to the subcutaneous or deep tissue target location, the radiation configured to cause the carrier particles to release at least some of the crosslinking agent, the released crosslinking agent configured to cause the prepolymer material to form into a gel or polymeric matrix.
Absstract of: WO2024173529A1
Methods are provided for enhancing regeneration of nerves, e.g. peripheral nerves. The method comprises administering to the subject, at or near the site of the peripheral nerve injury, an effective amount of a composition comprising an agent that promotes regeneration of the peripheral nerve by stimulating hedgehog signaling. Agents of interest include a smoothened agonist. The agent may be delivered in a fibrin-based hydrogel, which is optionally 3D printed and may be provided as a nerve wrap. In some embodiments administration is provided prior to injury, e.g. prior to surgery.
Absstract of: WO2024173099A1
A calcium peroxide-polycaprolactone (CPO-PCL) scaffold and its use as a bone tissue engineering scaffold or synthetic bone graft for treating a bone loss, disorder, or defect, including a craniofacial bone loss, disorder, or defect, is disclosed. The scaffold provides long-term oxygen generation in a controlled, concentration-dependent matter without triggering burst release at an early time point.
Absstract of: WO2024172593A1
The present invention relates to a maxillary skeletal expander and a manufacturing method therefor. The maxillary skeletal expander is printed through 3D printing, can fit the oral cavity of a patient and be used on both the upper jaw and the lower jaw, and does not require a separate fixing device such as a screw, and thus does not require a separate fixing procedure. In addition, compared to conventional maxillary skeletal expanders, the maxillary skeletal expander generates less of a foreign body sensation during use and does not cause injuries in the oral cavity, and thus does not cause pain.
Absstract of: WO2024172476A1
The present invention relates to a biocompatible polymer having a crosslinkable structure and having shape-restoring properties in the body temperature range, and a preparation method and use thereof and, more particularly, to a biocompatible polymer comprising polycaprolactone, polylactic acid, and polycaprolactone-co-polyglycidyl methacrylate copolymers, and a preparation method and use thereof. When the copolymer according to the present invention is mixed with polylactic acid and polycaprolactone to prepare a polymeric compound, it is possible to improve the compatibility of polylactic acid and polycaprolactone while improving the elasticity and elongation of the polylactic acid-polycaprolactone polymer and providing deformation recovery thereto. Therefore, the present invention is applicable to various medical products, including vascular stents, as well as various industrial products, and has the advantage of being easily manufactured using three-dimensional printing (3D printing) in addition to traditional manufacturing methods such as extrusion or injection.
Absstract of: AU2024200699A1
Embodiments of the disclosure include compositions and methods for providing an effective amount of activated or unactivated single-cell or spheroid fibroblasts, exosomes from fibroblasts, lysate from fibroblasts, apoptotic bodies from fibroblasts, and/or fibroblast-related products that are comprised in and/or on a substrate, such as a synthetic polymer or biopolymer scaffolding or biologic mesh, thereby generating a material to cover at least one wound and/or at least one burn of an individual.
Absstract of: AU2024205581A1
This document describes a process of producing gel microparticles, which are consistent in size and morphology. Through the process of coacervation, large volumes of gel microparticle slurry can be produced by scaling up reactor vessel size. Particles can be repeatedly dehydrated and rehydrated in accordance to their environment, allowing for the storage of particles in a non-solvent such as ethanol. Gel slurries exhibit a Bingham plastic behavior in which the slurry behaves as a solid at shear stresses that are below a critical value. Upon reaching the critical shear stress, the slurry undergoes a rapid decrease in viscosity and behaves as a liquid. The rheological behavior of these slurries can be adjusted by changing the compaction processes such as centrifugation force to alter the yield-stress. The narrower distribution and reduced size of these particles allows for an increase in FRESH printing fidelity.
Absstract of: AU2023235004A1
A method For manuFacturing a perFusable three-dimensional tissue model, containing therein a channel distributed across its entire structure, enabling the Flow oF Fluids, wherein bioprinting a vascular system with the extrusive method using bioink, the walls opening and closing the channel in its upper part being printed parallel to the channel axis, and bioprinting oF the model body with the extrusive method using bioink, the bioink For printing the body being diFFerent From the bioink used For bioprinting the vessels, placing the resulting system in an incubator, in a temperature in which bioink For printing the vascular system undergoes melt, removing the bioink, optionally, causing growth in the channel by means oF cells in a medium, wherein, the cross-section oF the channel being the same as the cross-section oF native vessels present in a living organism. The inventions relates to a bionic model with a perFusable system.
Absstract of: AU2023233429A1
A reinforcing and sealing construction for a bioprinted tissue model, which comprises a casing and sealing bioink, the casing comprising an inner module comprising a casing base (1) and a perforated cover (2), and an outer module comprising a container (3) comprising technological valves (5), an outer cover (4) and plugs (6) for technological valves (5). The invention also relates to a method for assembling the reinforcing and sealing construction.
Absstract of: US2024278490A1
Provided herein are methods which alter the mechanical and biological properties of polymeric materials. Also provided are compositions comprising the polymeric materials having said properties.
Absstract of: US2024278440A1
An elastomer robot comprises a flexible internal structure comprising a first flexible material, wherein the internal structure is tunable, and a flexible external structure comprising a second flexible material, attached to the internal structure, including an aperture configured to accept a fluid, wherein the external structure is tunable. Methods of use and production are also disclosed.
Absstract of: US2024277948A1
An electronic module for a medical device such as an inhaler is disclosed, the electronic module comprising a printed circuit board, and a damper configured to dampen energy transfer to and/or from a battery when a battery is connected to the electronic module and the electronic module is exposed to mechanical shock.
Absstract of: US2024277904A1
The present invention is directed to gels, cryogels and other polymer scaffolds, solid surfaces, aggregates, films and coatings comprising a soluble chemically modified cross-linked chitosan useful for 3D cell and organoid bioprinting and other uses in biology, medicine, bioanalytics and environmental sciences and methods of preparation thereof.
Absstract of: US2024277452A1
Systems and methods for fabricating indirect bonding trays are disclosed. Physical models of a patient's teeth can be created with non-functional placeholder brackets, impressions of which can be transferred to indirect bonding trays. This can create wells in which functional brackets can be placed into, reducing errors created from transferring functional brackets from the physical model onto the indirect bonding trays.
Absstract of: WO2024170549A1
The present invention relates a bioprinted three-dimensional tumor model which is able to reproduce the cellular heterogeneity, the spatial architecture, and the tissue-specific ECM of the tumor microenvironment. In addition, the invention refers to a process for preparing such three-dimensional tumor model, to methods for testing anticancer drugs as well as to the use of the tumor model in developing personalized medicine and developing new therapies based on the understanding of the in vitro tumor progression.
Absstract of: WO2024170473A1
The invention provides an excipient composition for the preparation of an amorphous solid dispersion or amorphous solid solution suitable for, i.a., 3D printing of immediate release tablets. The excipient composition comprises: a) 8-20 % by weight of the excipient composition of sugar alcohol, and b) 80-92 % by weight of the excipient composition of a polymer blend, the polymer blend comprising a first polymer component and a second polymer component in a weight ratio of 1:0.55 - 1:1.75, the first polymer component being a copolymer of 1-vinyl-2 -pyrrolidone and vinyl acetate, and the second polymer component being polyethylene glycol-polyvinyl alcohol graft copolymer.
Nº publicación: US2024277889A1 22/08/2024
Applicant:
CALIFORNIA INSTITUTE OF TECH [US]
California Institute of Technology
Absstract of: US2024277889A1
Techniques for deep tissue in vivo printing are described. Some implementations of the disclosure relate to a method that includes: obtaining a biopolymer mixture including prepolymer material and a crosslinking agent encapsulated in carrier particles; delivering the biopolymer mixture to a subcutaneous or deep tissue target location of a subject; and transmitting with a bioprinting device, via transcutaneous application, radiation to the subcutaneous or deep tissue target location, the radiation configured to cause the carrier particles to release at least some of the crosslinking agent, the released crosslinking agent configured to cause the prepolymer material to form into a gel or polymeric matrix.
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