Absstract of: US2024352179A1
The present disclosure provides curable compositions comprising one or more of photo-polymerizable urethane prepolymers having alternating hard and soft blocks, as well as polymeric materials formed from the curable compositions. Further provided herein are methods of producing the compositions and using the same for the fabrication of medical devices, such as orthodontic appliances.
Absstract of: CN121059903A
本发明属于生物医用材料技术领域,提供了一种盆腔术后充填材料及其制备方法和应用。本发明的盆腔术后充填材料包含凝胶化生物膜基质和纳米弹性材料,限定了原料的质量比。本发明采用凝胶化生物膜基质,保留细胞外基质原有的三维结构、胶原纤维、非胶原蛋白及生长因子等成分,具有优异的生物相容性;采用物理交联法将凝胶化生物膜基质与纳米弹性材料交联,无需化学交联剂,无副作用;通过静电动态液体纺丝制备纳米弹性材料,促进充填材料与宿主细胞的相互融合,提高修复效果;采用天然聚合物和合成聚合物制备纳米弹性材料,赋予良好的生物相容性、稳定的支撑作用以及良好的拉伸应变,防止脏器脱垂,加快术后修复。
Absstract of: CN121059320A
本发明公开一种复合牙颌模型,包括:上颌牙颌模型、下颌牙颌模型和能够锁定上下颌相对位置关系的定位组件;上颌牙颌模型包括上颌牙齿部和支撑上颌牙齿部的上颌支撑部;下颌牙颌模型包括下颌牙齿部和支撑下颌牙齿部的下颌支撑部;定位组件包括与上颌支撑部连接的上颌定位件和与下颌支撑部连接的下颌定位件;其中,上颌定位件和下颌定位件直接装配或间接装配后,能够将复合牙颌模型的上下颌相对位置定位至患者目标颌位的对应位置。本发明还提供了复合牙颌数字模型的设计方法,以及牙科器械的制作方法。
Absstract of: WO2024200441A1
Described herein is a computer-implemented method for constructing in the form of designing in a virtual environment a custom ear device in an automated process utilizing a trained neural network. The computer-implemented method described is configured to allow for changing the output form the neural network to create change to an automatic generated custom ear device design. Furthermore, described herein is a system utilizing a processor running the method described herein to automatically generate virtually constructed custom ear devices that may be modified to adjust for any incorrect outputs generated by a neural network.
Absstract of: US2025361406A1
The invention relates to a radiation-curing composition for the manufacture of dental components using the DLP process or SLA process, comprising, based on the total mass of the radiation-curing composition (i) one or more radically polymerizable monomers in a combined mass fraction of 60% or more, (ii) one or more hexaarylbiimidazole compounds in a combined mass fraction in the range of 0.1 to 5%, and (iii) one or more mercaptotetrazole compounds in a combined mass fraction in the range of 0.1 to 5%, wherein the combined mass fraction of fillers in the radiation-curing composition is less than 30%.
Absstract of: JP2024057092A
To provide a system for manufacturing and using an implant for correcting a defect of a bone structure.SOLUTION: The implant includes a first surface comprising a shape configured to interface with a surface of the bone structure. In some examples, the implant includes a second surface opposite the first surface and substantially conformal to the shape of the first surface, the second surface comprising three or more point features on the second surface, wherein the three or more point features comprise a first point feature, a second point feature, and a third point feature that form nodes of a triangle, and each of the three or more point features is recessed below the second surface.SELECTED DRAWING: Figure 5D
Absstract of: WO2025247506A1
The present disclosure generally relates to a paste for carrying an active pharmaceutical ingredient (API), preferably a GLP-1 agonist and a permeation enhancer, preferably a fatty acid and/or a pharmaceutical acceptable salt thereof, such as sodium decanoate, preferably for use in a screen printing process for printing a pharmaceutical composition. The present disclosure further relates to a method for preparing a paste, and the use of a paste in an additive manufacturing process.
Absstract of: WO2025250016A1
Herein is disclosed a method of manufacturing a seat unit for a wheelchair, and a seat unit for a wheelchair The method comprises the steps of determining a user's needs for support and pressure relief, and thereafter selecting a basic seat cushion module (1) and a basic backrest module (2) before 3D-printing a seat unit adaptation module (4; 5) using information about the determined support and pressure relief needs of the user, for adapting the basic seat cushion module (1) and/or the basic backrest module (2) to the user. The adaptation module (4; 5) is printed with an open 3D structure (3).
Absstract of: WO2025247746A1
A method for manufacturing a medical bone connecting device (10) is proposed that serves to connect two bones (V, H) or bone parts of a human or animal patient. The method comprises at least the following steps: a.) targeted deposition (80) in a common layer (17) of one or more strands (13) of reinforcing fibers (11) embedded in a matrix material (12), b.) repetition (81) of step a.) for a plurality of successive layers (17), in order to produce a preform (18) of the bone connecting device (10), and c.) compression (82) of the preform (18) in a mold (70) to form the bone connecting device (10). The strand or strands (13) are deposited in such a way in step a.) that they follow a multiple curved path (15) without crossing themselves or each other. Furthermore, a bone connecting device (10) manufactured according to this method is disclosed.
Absstract of: WO2025247979A1
The invention relates to a pharmaceutical formulation suitable for the manufacture of unit doses of a solid or semi-solid medicament by 3D printing, to a printing cartridge containing such a pharmaceutical formulation, and to the use of this pharmaceutical formulation for the manufacture of unit doses of a solid or semi-solid medicament by 3D printing, to a printing cartridge containing such a pharmaceutical formulation, and to a method for preparing a medicament in the form of unit doses by 3D printing using such a formulation.
Absstract of: WO2025250670A1
A three-dimensional ("3D") printed orthopedic fixation implant can reduce stress shielding and/or enhance osseointegration. The implant can include: a head defining a proximal end of the implant; a tip defining a distal end of the implant; a core extending from the head to the tip, the core being elongate; and threads extending along at least a portion of the core. One or more functionally graded lattice structures can be propagated longitudinally and/or radially in at least portions of the core. A density of the one or more functionally graded lattice structures can have a varying longitudinal gradient and a varying radial gradient.
Absstract of: WO2025248557A1
This invention relates to the preparation of bone grafts from human hard tissues, such as teeth, bone, and cartilage, that retain osseoinductive potential. The grafts are processed through optimized lab procedures to preserve their biological activity, achieve sterilization, and minimize water content for enhanced shelf life. These grafts can be formulated into particulate, block, or dough/pastel - like forms. The particulate matter can be combined with body fluids containing growth factors to create a moldable material for packing into bone defects, promoting superior osteogenesis. Additionally, the particulate matter can be used in 3D printing to produce customized grafts with controlled porosity based on CT scans and computer-aided design (CAD). Block grafts can be machined into precise shapes using CAD models and computer-aided machining (CAM).
Absstract of: WO2025249198A1
This photocurable composition for stereolithography comprising: a di(meth)acrylic monomer (A) containing two (meth)acryloyloxy groups; a mono(meth)acrylic monomer (B) containing one (meth)acryloyloxy group and at least one group selected from the group consisting of groups (b1) to (b13); and a photopolymerization initiator. * indicates the bonding position. Any one of Rb1A to Rb1G is a divalent group, and the rest are H or a monovalent group. One of Rb2A and Rb2B is a divalent group, the other is H or a monovalent group, and each of Rb2C and Rb2D is H or a monovalent group. Any one of Rb3A to Rb3I is a divalent group, and the rest are H or a monovalent group. In the group (b5), each of Rb5A to Rb5H is H or a monovalent group.
Absstract of: US2025372251A1
Provided herein are computer-implemented methods of detecting cardiovascular disease in a subject. The methods include receiving an electrocardiogram (ECG) image for the subject; applying a machine-learning based algorithm to the ECG image for the subject, the algorithm being trained to distinguish a printed ECG reading of a heart with cardiovascular disease from a printed ECG reading of a healthy heart; comparing outputs of the algorithm to patterns of algorithm outputs for ECG images from healthy subjects and subjects with one or more cardiovascular diseases; and determining if the subject has cardiovascular disease based upon the outputs of the algorithm.
Absstract of: US2025369798A1
A skin-wearable photodetector module includes an array with a plurality of photodetectors and a plurality of optical filters, and each photodetector is configured to receive an optical input from an optical filter having a central wavelength in a wavelength range of about 100 nm to about 1000 nm. Each photodetector includes a substrate with a first major surface having an electrode thereon, and a second major surface overlying an optical filter, an anode within an interior region of the electrode, an active layer including a. ternary mixture of an electron donor, an electron acceptor, and at least one charge carrier trap material, and a cathode that contacts the active layer.
Absstract of: US2025366894A1
A three-dimensional (“3D”) printed orthopedic fixation implant can reduce stress shielding and/or enhance osseointegration. The implant can include: a head defining a proximal end of the implant; a tip defining a distal end of the implant; a core extending from the head to the tip, the core being elongate; and threads extending along at least a portion of the core. One or more functionally graded lattice structures can be propagated longitudinally and/or radially in at least portions of the core. A density of the one or more functionally graded lattice structures can have a varying longitudinal gradient and a varying radial gradient.
Absstract of: US2025366893A1
A bone insert includes a cap having a convex top surface, an elongated stem, and a barrier between the cap and the stem. The stem of the bone insert is inserted into a hole formed in a host bone until the barrier is pressed against the exposed bone. The bone implant can be placed against a small focus contact point on the cap. Liquid cement can be injected into a space volume between the host bone and a bone implant. The cap can be made of a material and/or have surface features that create a strong bond with the cement when the liquid cement cures. The stem can be made of a material and/or have bone ingrowth surface features that create a strong bond with the bone.
Absstract of: US2025366997A1
The present invention relates to a method for using a lyophilization hyaline cartilage powder to produce a composition for regenerating cartilage, and a composition for regenerating cartilage produced by using the method, the method comprising: A) a step for preparing hyaline cartilage; B) a step for freeze-drying and crushing the hyaline cartilage, and producing a lyophilization hyaline cartilage powder; C) a step for producing an adipose tissue extract from autologous adipose tissue; and D) a step for producing a composition which is for regenerating cartilage and including the lyophilization hyaline cartilage powder and the adipose tissue extract.
Absstract of: US2025366978A1
Disclosed herein are devices and methods of making and use thereof.
Absstract of: US2025366979A1
Disclosed herein are devices and methods of making and use thereof.
Absstract of: US2025366995A1
The present invention relates to a medical device manufactured using the additive manufacturing process (3D printing). It is a medical device used preferably as a bone graft composed of a porous structure based on bioceramics based on β-tricalcium phosphate (β-TCP) or hydroxyapatite, which may or not contain nanostructures in its composition, for example: carbon nanostructures (graphene, graphene oxide, reduced graphene oxide, carbon nanotubes, etc.) and, in preferred embodiments, stem cells and polymeric membrane. Also, the present invention relates to the use of this device as a bone graft and the process of preparing this device.
Absstract of: US2025366958A1
Systems and techniques for training one or more neural networks to automatically determine placement of a digital representation of an orthodontic appliance are disclosed including comparing one or more aspects of the second representation of a 3D printed part with one or more respective aspects of a first representation of the 3D printed part, generating a reconstruction error based on the comparing, and when the reconstruction error is greater than a predetermined threshold, assigning one or more result labels that specify that the respective aspects of the 3D printed part were not correctly fabricated and when the reconstruction error is less than the predetermined threshold, assigning one or more result labels that specify that the respective aspects of the 3D printed part were correctly fabricated.
Absstract of: US2025366922A1
A plate for fixating bone, the plate comprising: a plurality of ribs defining a plurality of openings, wherein a first portion of the plurality of ribs define a lattice structure and a second portion of the plurality of ribs define at least four mounting holes. Another aspect of the present disclosure relates to a method for tailoring a plate for fixating bone. The method can include determining an initial design of the plate. The method can include analyzing radiation through the initial design. The method can include determining, based on analyzed radiation, if dosimetric characteristics are desirable. The method can include analyzing structural strength of the initial design. The method can include determining, based on the analyzed structural strength, if structural strength is sufficient.
Absstract of: US2025367876A1
A system for additive manufacturing a medical device, the system comprising a first dispensing system, a second dispensing system, a deposition apparatus, and a deposition substrate on a surface of which the deposition apparatus is configured to deposit at least one elastomeric material into a filament. The deposition apparatus receives the at least one elastomeric material from the first and second dispensing systems in proportions effecting a desired property in the medical device. The deposition apparatus may comprise heating and/or cooling elements, a sonic vibration module, and/or a pneumatic suck-back valve. The deposition substrate may have a configuration corresponding to a desired shape of the medical device and is configured to rotate and/or translate relative to the deposition apparatus. The system comprises a controller configured to control the deposition.
Nº publicación: US2025367422A1 04/12/2025
Applicant:
GEORGIA TECH RES CORPORATION [US]
Georgia Tech Research Corporation
Absstract of: US2025367422A1
A microneedle array is provided for administrating a drug or other substance into a biological tissue. The array includes a base substrate; a primary funnel portion extending from one side of the base substrate; and two or more solid microneedles extending from the primary funnel portion, wherein the two or more microneedles comprise the substance of interest. Methods for making an array of microneedles are also provided. The method may include providing a non-porous and gas-permeable mold having a two or more cavities each of which defines a microneedle; filling the cavities with a fluid material which includes a substance of interest and a liquid vehicle; drying the fluid material to remove at least a portion of the liquid vehicle and form a plurality of microneedles that include the substance of interest, wherein the filling is conducted with a pressure differential applied between opposed surfaces of the mold.