Alerta

MOLD WITH WEAKENED REGION

Absstract of: US2025161006A1

A mold is for thermoforming a dental appliance. The mold includes a first section of the mold and a second section of the mold. The second section includes a feature having a complex shape, an undercut, or a bite edge. The mold further includes a weakened region that joins the first section to the second section. The weakened region is breakable, deflectable, or deformable in response to a first threshold force to enable the first section and the second section to be removed from the dental appliance after the dental appliance is formed over the mold. The first threshold force is less than a second threshold force that would damage or permanently deform the dental appliance.

SUTURABLE CUFF, METHOD OF INTEGRATING A TISSUE CONSTRUCT WITH A HOST ORGAN OR VASCULATURE, AND METHOD OF MAKING A SUTURABLE CUFF

Absstract of: US2025160834A1

A suturable cuff for integrating a tissue construct in vivo with a host organ or vasculature comprises a hollow body having an anastomotic end, an anchoring end, and one or more lumens, where each lumen extends through the hollow body from a proximal opening at the anastomotic end to a distal opening at the anchoring end. The anastomotic end is configured for integration with one or more body vessels, and the anchoring end includes one or more anchoring features for connection with the tissue construct.

ADDITIVE MANUFACTURING DEVICES AND METHODS

Absstract of: US2025162253A1

In the embodiments of the present disclosure, additive manufacturing devices and methods are provided. The additive manufacturing device includes a light source, a building device, and a light scattering member. The light source is configured to provide light to cure photocurable resins. The building device includes a resin tank configured to store the photocurable resins. The building device has a building surface on which the photocurable resins are cured. The light scattering member is arranged between the light source and the building surface.

PATIENT INTERFACE

Absstract of: US2025161616A1

A patient interface comprises a support structure and a seal-forming structure. The support structure is arranged to support the sealing portion and is configured to connect to the frame. The sealing portion comprises textile and is attached to the support structure along an outer perimeter of the sealing portion such that in use the sealing portion may be in tension due to reactive stress of the support structure and/or a resilient stretch characteristic of the textile such that the sealing portion exerts a force against the patient's face.

SELECTIVELY PERMEABLE ANNULUS FIBERS AND METHODS OF USING SAME

Absstract of: US2025161532A1

Aspects of the invention include systems and methods for producing selectively permeable cell laden solid core fiber structures, and for producing three-dimensional (3D) biological structures for digital files. In embodiments, the printed fibers comprise living cells embedded in at least one annulus layer or the printed fibers comprise a solid core of at least one biological material. The tissue fiber can be used in tissue engineering as synthetic tissue structures.

Allograft-Polymer Hybrids, Methods of Making and Methods of Use

Absstract of: US2025161533A1

Provided herein are bioresorbable, bioregenerative composite materials and compositions to regenerate tissues or organs to repair tissue or organ defects and constructs printed from the same as 3D structures shaped and sized to fill a tissue or organ defect. The composite materials are bioresorbable polymers, for example, polycaprolactone, and a bioresorbable graft material, for example, demineralized bone matrix. Also provided are methods for making the composite materials and compositions and methods for regenerating tissues or organs and repairing a tissue or organ defect using the constructs.

CYBER-PHYSICAL WATERMARKING WITH INKJET EDIBLE BIOPRINTING

Absstract of: US2025166110A1

A method of ascertaining identity, verification, or authentication of a product is disclosed which includes embedding a predetermined watermark on a host image, thereby generating an edible watermarked image, printing the watermarked image using edible ink on an attack-resistant edible substrate, affixing the printed substrate onto the product, providing a color reference chart along with the watermarked image, obtaining an image of the watermarked image from the product, establishing correspondence between the watermarked image and the color reference chart, correcting the obtained image based on the established correspondence, extracting the embedded predetermined watermark from the corrected watermarked image, and determining identity, verification, and authentication of the product by analyzing the extracted predetermined watermark of the watermarked image.

THREE-DIMENSIONAL SYNTHETIC LYMPHOID ORGANS AND ORGANOIDS FOR ANTIBODY DESIGN AND TESTING

Absstract of: US2025164465A1

Provided herein are methods and systems for bio-printing of three-dimensional organs and organoids. Also provided herein are bio-printed/extruded three-dimensional lymphoid organoids for use in the generation and/or the assessment of immunological products and/or immune responses. Also provided herein are methods and system for lymphoid organoids for use in antigen and epitope discovery, characterizing immune response, and therapeutic compounds testing.

LIVING BIOREACTOR COMPOSITIONS AND METHODS OF USE

Absstract of: WO2025106439A1

The present disclosure provides compositions comprising a structure for use as a therapeutic cell niche. Additionally, provided herein are methods for using such compositions, e.g., for use in cell therapy in a subject in need thereof.

3D PRINTING OF A UNITARY PIECE IN A METAL MATERIAL

Absstract of: WO2025103994A1

The present invention relates to a dental or surgical handpiece (1) formed by a head (10) and a gripping handle (11), each provided with at least one integrated internal duct (2) selected from a pneumatic duct (20), a light transmission duct (23), and a blind duct (24) suitable for housing one or more electronic sensors (5), characterised in that at least one element selected from an internal shell (111) of the handle (11) and the head (11) is made by 3D printing in metal and contains the pneumatic duct (20) and/or the light transmission duct (23) and/or the blind duct (24) as an integrated internal duct (2) in a single unit.

IMPLANTS FOR TEETH AND BONE

Absstract of: WO2025102118A1

The present disclosure relates to implants for teeth and bone. The implants are prepared from a polymer of the poly (aryl ether ketone) family, preferably poly ether ketone (PEK), and are activated with plasma to improve integration with teeth and bone. Methods and kits related to use of the implants are also disclosed.

3-D BIOPRINTING COMPRISING BIOLOGICALLY-RELEVANT MATERIALS AND RELATED METHODS

Absstract of: WO2024015237A1

The present disclosure provides a method of bioprinting a 3-D structure comprising one or more biologically-relevant materials on a super-hydrophobic surface. In one embodiment, the method comprises providing a composition having one or more biologically-relevant materials dispersed within a biocompatible medium. A pattern comprising a hydrophilic material is deposited on a defined area of the super-hydrophobic surface, wherein the pattern is modeled after a biological structure. The composition having the one or more biologically-relevant materials is then bioprinted atop the hydrophilic surface to form a 3-D structure, wherein the hydrophilic surface maintains the 3-D structure in a desired position or shape on the super-hydrophobic surface.

FIBROCARTILAGE-DERIVED BIOINK COMPOSITION, BONE GRAFT COMPOSITION CONTAINING SAME, AND MANUFACTURING METHOD THEREFOR

Absstract of: EP4556032A1

The present invention relates to a fibrocartilage-derived bioink composition, a bone graft composition containing same, and a manufacturing method therefor. More specifically, it is identified in the present disclosure that the inner, mid, and outer compartments of the meniscal cartilage tissue based on anatomical location differ from each other in terms of physicochemical property, whereby use is made of the extracellular matrix derived from each compartmentalized tissue to provide 3D-printing bioink compositions and bone grafts, each having distinct physicochemical properties, which can be utilized with controlled physicochemical properties according to desired applications.

SURGICAL CLIP APPLIER COMPRISING ADAPTIVE CONTROL IN RESPONSE TO A STRAIN GAUGE CIRCUIT

Absstract of: EP4555969A2

A surgical clip applier comprising an electric motor system is disclosed. The electric motor system is configured to drive a clip firing system of the surgical clip applier. The surgical clip applier further comprises a control system configured to control the electric motor system. The control system is configured to monitor a strain gauge circuit to assess the crimping force experienced by the clip firing system. In at least one instance, one or more strain gauges are mounted to a drive shaft and/or jaw of the clip firing system. The control system modifies the operation of the surgical clip applier when the voltage of the strain gauge circuit exceeds and/or falls below a threshold. In at least one instance, the control system modulates the width, or duration, of voltage pulses applied to the electric motor system to control the speed of the electric motor system.

PATIENT INTERFACE AND CUSHION THEREOF

Absstract of: WO2024011290A1

A patient interface comprising a plenum chamber, a seal-forming structure constructed and arranged to form a seal with a region of the patient's face surrounding an entrance to the patient's airways, and a vent to allow a continuous flow of gases exhaled by the patient from an interior of the plenum chamber to ambient. The seal-forming structure may comprise a cushion, the cushion being deformable and resilient and at least partially formed by a lattice structure.

CLEAR ORTHODONTIC ALIGNER

Absstract of: WO2024013670A1

The present invention relates to a clear orthodontic aligner comprising at least one molecule capable of changing color or color intensity (CCM). Furthermore, the invention relates to a process for obtaining a clear orthodontic aligner by means of three-dimensional (3D) printing.

PROCESS FOR MANUFACTURING A DENTAL IMPLANT, DEVICE FOR ANODISATION OF A DENTAL IMPLANT, AND DEVICE FOR ACID ETCHING AND COATING OF A DENTAL IMPLANT

Absstract of: EP4555972A1

The present invention describes a 3D printed dental implant manufacturing process in which a chemical treatment process is carried out, preferably acid etching, on the external surface of said implant; and an anodizing process on the inner surface of the cavity of said implant.Furthermore, the present invention refers to a device for aligning an implant body for the CNC machining process through a clamp holder shaft; an implant cavity anodizing device; and a device for etching the outer surface of an implant configured to be implemented in an implant manufacturing process, wherein the implant manufacturing process can be automated and performed on multiple implants simultaneously.

ラピッドプロトタイピングまたはラピッドマニュファクチャリング法において使用するための光線硬化性組成物

Absstract of: WO2023213699A1

The invention relates to a polymerisable, radiation-curable composition, in particular a UV/Vis-curable, UV-curable or Vis-curable composition comprising (i) monomers and (ii) at least one further component, wherein the (i) monomers comprise (a) at least one urethane (meth)acrylate that is at least difunctional, (b) at least one monofunctional acrylate having an alicyclic group and/or at least one monofunctional methacrylate having an alicyclic group, and (ii) the at least one further component comprises (c) at least one photoinitiator for the UV and/or visible range or a photoinitiator system for the UV and/or visible range. The composition according to the invention is suitable for producing dental prosthetic parts, orthopaedic instruments or dental pre-forms, which are characterised by a) a flexural strength of greater than or equal to 75 MPa, and/or b) a modulus of elasticity of greater than or equal to 2600 MPa, and/or c) a water absorption of less than 45 μg/mm3, wherein these dental prosthetic parts, orthopaedic instruments or dental pre-forms can be produced using a rapid prototyping process or using a rapid manufacturing or rapid tooling process.

牙颌模型底托、牙颌模型及牙颌模型套组

Absstract of: CN222870668U

本实用新型公开一种牙颌模型底托，用于承载牙颌模型，牙颌模型底托用于承载牙颌模型的承载面设有若干个凸台结构，凸台结构与设置于牙颌模型底面的凹槽结构凹凸匹配，装配后，凸台结构远离承载面的一端与凹槽结构远离牙颌模型底面的一端抵接，并且承载面与牙颌模型底面具有预设间隙。本实用新型还提供一种牙颌模型，牙颌模型的底面设置有若干个与牙颌模型底托承载面上的凸台结构凹凸匹配凹槽结构。本实用新型还提供一种牙颌模型套组，包括上述的牙颌模型底托和牙颌模型。本实用新型提供的牙颌模型底托、牙颌模型，以及牙颌模型套组，能够解决牙颌模型的底面因打印不平整导致的放置不平稳的问题，有利于提升隐形矫治器切割过程中的切割精度。

一种智能电子导管及其制备方法

Absstract of: CN120003020A

本发明公开了一种智能电子导管及其制备方法，属于体内医疗传感技术领域。包括以下步骤：制备银/氯化银参比电极、钙离子传感电极、钾离子传感电极、钠离子传感电极、胆红素传感电极、牛磺酸传感电极及过氧化氢传感电极；对静脉导管表面进行亲水处理，附着制备的金属凝胶打印浆料；将金属凝胶打印浆料3D打印在静脉导管表面；裁剪各传感电极和参比电极并黏附至金属凝胶打印线路末端后进行加热以得到金属凝胶打印线路；对金属凝胶打印线路进行封装处理，得到电子导管。相较于现有技术，本发明的有益之处在于，实现在医疗导管表面打印金属凝胶，并设计针对肠外营养各类并发症的化学信号传感器，结合机器学习进行趋势预测。

一种基于体积光固化打印和悬浮生物3D打印的载药水凝胶微针构建方法

Absstract of: CN120003024A

本发明公开了一种基于体积光固化打印和悬浮生物3D打印的载药水凝胶微针构建方法，涉及生物材料技术领域，所述方法包括下述操作步骤：S1、制备光固化悬浮支撑浴；S2、制备载药水凝胶；S3、悬浮打印载药水凝胶；S4、体积光固化打印微针阵列。该基于体积光固化打印和悬浮生物3D打印的载药水凝胶微针构建方法，通过在该悬浮支撑浴中根据药物所需的位置，悬浮打印载药水凝胶微球；悬浮打印完毕后，采用体积光固化打印技术，在该悬浮支撑浴内体积打印水凝胶微针阵列，实现载药水凝胶微球在微针阵列中的可控分布。

具有抗口腔鳞癌和促黏膜修复功能的光热复合材料及其制备方法和应用

Absstract of: CN120000851A

本发明属于光热材料应用领域，具体涉及一种具有抗口腔鳞癌和促黏膜修复功能的光热复合材料及其制备方法和应用。光热复合材料，包括纳米纤维膜以及海绵材料；所述的纳米纤维膜包括胶原蛋白和聚己内酯PCL；所述的海绵材料包括MXene、丝素蛋白和胶原蛋白。本申请的技术方案利用静电纺丝技术制成纳米纤维膜模拟黏膜上皮屏障并提高整体材料的缝合性能，采用低温3D打印制备含有MXene的口腔黏膜修复材料，制备的复合材料兼具良好的光热性能、口腔黏膜修复功能及缝合性能。

一种可调式阻鼾器及其制造方法

Absstract of: CN120000412A

本发明提供一种可调式阻鼾器及其制造方法，涉及阻鼾器技术领域，包括：上颌基托和下颌基托，上颌基托和下颌基托分别能够套设在上齿和下齿的外侧，下颌基托的前端设置有下颌限位板，上颌基托的前端通过第一调节机构连接有第一上颌限位板，第一上颌限位板用于与下颌限位板限位配合，上颌基托的后端通过第二调节机构连接有第二上颌限位板，第二上颌限位板用于与下颌基托的后端接触，第一调节机构和第二调节机构分别能够前后调节第一上颌限位板和上下调节第二上颌限位板；解决现有技术中的阻鼾器不能调节，适用范围有限和难以应对佩戴者的个体差异等问题。

一种颌面缺损修复植入假体制作方法、植入假体及模具

Absstract of: CN120000382A

本发明公开一种颌面缺损修复植入假体制作方法、植入假体及模具，涉及骨颌面修补技术领域，包括：采集患者颅骨影像学数据；根据医学数据建模软件对患者颅骨影像学数据进行建模获取颅骨模型数据和面部软组织模型数据；根据颅骨模型数据和面部软组织模型数据确定植入假体模型；根据植入假体模型制作最终植入假体。本发明通过获取颅颌面影像资料，建立颅骨模型和面部软组织模型，确定植入假体并展示给患者，患者可直观看到植入假体效果，使医生和患者能够更好的沟通，使患者能够直观的看到术后效果，并进行修改确认最终植入假体，植入假体可通过多次修改模拟确定，减少医生对经验的依赖及术中出现的各种情况导致术后偏差。

基于定制SESAM激光器的触觉导航地图生成方法及系统

Nº publicación: CN120008580A 16/05/2025

Applicant:

陕西师范大学

Absstract of: CN120008580A

本发明公开了基于定制SESAM激光器的触觉导航地图生成方法及系统，涉及环境感知无障碍辅助技术领域，包括获取目的地并规划路线，使用定制SESAM激光器进行环境扫描；进行数据处理，生成触觉感知导航地图模型；使用即时3D打印设备生成触觉导航地图，实时检测环境更新地图。本发明提供的基于定制SESAM激光器的触觉导航地图生成方法使用SESAM激光器进行高精度环境扫描有效克服了现有激光器设备在复杂环境中精度不足的问题，使系统能够获取完整且真实的环境信息，将模型分为光滑的通行区和有纹理的障碍物，简洁的构造使3D打印成本更低，用户更易掌握模型。本发明在准确性、成本以及用户适应方面都取得更加良好的效果。