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226
results.
Updated on
06/06/2025 [07:19:00]
Results 25 to 50 of 226
Absstract of: CN115740495A
The invention relates to a method for 3D printing of a bone trabecula oral implant. The bone trabecula oral implant comprises an implant base body and a bone trabecula porous structure which are integrally formed. The bone trabecula porous structure is positioned in the axial middle section of the implant base body; and the implant base body is provided with an external thread. The printing method comprises the following steps: obtaining an oral implant 3D model with a bone trabecula porous structure through three-dimensional design software; carrying out molding manufacturing, sand blasting and annealing treatment by utilizing an SLM technology to obtain a bone trabecula oral implant primary product; and forming a tantalum metal coating on the surface of the primary product of the bone trabecula oral implant by using a vapor deposition technology to obtain the bone trabecula oral implant with the tantalum coating. The bone trabecula oral implant obtained by the method is high in density and mechanical strength, favorable for the implant to exert a good repairing effect, and excellent in application prospect.
Absstract of: WO2024084040A1
The disclosure relates to an aqueous bioink solution for use in light-based bioprinting applications, comprising: (a) 0.5-95 wt % water-soluble prepolymer; (b) 0.001-5 wt % biocompatible metal acylphosphinate photoinitiator; (c) 0.001-10 wt % biocompatible light absorber; and (d) 5 to 99.5 wt % solvent. The disclosure further relates to a method of using the aqueous bioink solution including living cells and a method of using the aqueous bioink solution without living cells (acellularly).
Absstract of: CN120078562A
本发明涉及一种防移位自适应自锁式人体管腔支架与制作方法，属于医疗器械领域。本发明包括支架单元和连接单元，相邻支架单元通过连接单元连接，其结构特点在于：所述支架单元包括呈菱形结构设置的主体框架、以及设置在主体框架内部的连接横梁、过渡横梁和榫卯横梁，所述连接横梁、过渡横梁和榫卯横梁依次连接，所述连接横梁和榫卯横梁均与主体框架连接，两个榫卯横梁上均设置有多个榫头，相邻榫头之间形成榫槽，其中一个榫卯横梁上的榫头与另一个榫卯横梁上的榫槽连接，其中榫头的数量不少于3个，榫槽的数量不少于2个。
Absstract of: CN120078956A
促进骨质疏松性骨缺损修复的人工骨及其制备方法，属于生物医学材料技术领域。本发明的人工骨由89.65wt%‑89.85wt%的聚乳酸‑羟基乙酸共聚物、9.85wt%‑10.15wt%的纳米羟基磷灰石以及0.1wt%‑0.5wt%的唑来膦酸复合而成。该人工骨中，纳米羟基磷灰石和唑来膦酸在聚乳酸‑羟基乙酸共聚物中均匀分散，结合人工骨表面的多孔结构，有利于成骨细胞在表面的附着，有利于新生骨组织的长入；唑来膦酸的膦酸根能够与纳米羟基磷灰石螯合生成稳定的化学键，将其引入到聚乳酸‑羟基乙酸共聚物中，可以实现唑来膦酸的有效负载，唑来膦酸的有效负载能够抑制破骨细胞过度活化导致的骨吸收增多，修复骨质疏松性骨缺损。
Absstract of: CN120078532A
本发明涉及骨性Ⅲ类上颌发育不足的矫治器技术领域，尤其涉及一种基于数字化可视化颌位重建技术的矫治器制作方法，所述矫治器包括基底和颌垫，矫治器的制作包括以下步骤：S1：获取患者相关数据及第一次口扫数据，确定矫治器方案；S2：获取患者的静态咬合状态，确定初步的咬合目标位置，并获得第二次口扫数据；S3：将所述第一次口扫数据和所述第二次口扫数据分别导入至设计软件中，生成数字化模型；S4：通过数字化颌架确定最终颌位；S5：设计基底模型，并3D打印；S6：设计颌垫模型，并3D打印；本方法制作的矫治器组织面能完美匹配患者的牙齿外形，咬合记录目标位置更加符合人体生物学基础，设计更为精确，并可有效防止矫治器脱落。
Absstract of: US2022370300A1
Radically polymerizable dental material, which contains at least one ABA or AB block copolymer, preferably at least one monofunctional, radically polymerizable monomer (a) and preferably at least one radically polymerizable urethane di(meth)acrylate telechel (b).
Absstract of: EP4523890A2
The invention relates to a system for producing pharmaceutical objects, such as tablets, granules and capsules, via 3D printing. The system comprises a 3D printing machine (2) with a mechanical system (3) movable in one or more directions, at least one print head (5) with at least one nozzle (37) being movable by the mechanical system (3) and a base system (4) carrying a print base (6) for receiving a prepared mixture (27) applied by the print head (5) and comprising formatted print locations (49) on the base (6) for shaping the pharmaceutical object. The formatted print locations (49) can be adapted to receive a blister such that the pharmaceutical objects can be printed directly inside the blister. The system can further comprise a closing device for applying a sealing membrane or film to hermetically seal the blister after the printing is completed. The invention further relates to a method for producing pharmaceutical objects with the system.
Absstract of: CN120055291A
本发明提供一种新型钛钽合金牙科种植体材料及其制备方法和应用，该制备方法包括以下步骤：S1.准备钛钽合金粉末，按质量百分比计包括以下元素成分：Ta：30‑50％、余量为Ti，待用；S2.建立牙科种植体三维模型，使用选择性激光熔化将S1所述钛钽合金粉末制备得到目标，所述3D打印激光功率为200‑350W，扫描速度为600‑800mm/s，层厚为20‑40μm，得到牙科种植体，待用；S3.对S2所得牙科种植体进行等离子体表面处理，功率为100‑300W，时间为10‑20min，即得所述新型钛钽合金牙科种植体材料。所得新型钛钽合金牙科种植体材料具有较低的弹性模量、优异的力学性能和生物相容性，能促进细胞增殖，显著改善了种植体的生物力学性能，兼顾耐用性和减轻应力屏障效应，特别适用于高要求临床场景。
Absstract of: CN120053753A
本发明公开了一种基于3D打印的复合人工骨及其制备方法。复合人工骨的制备方法包括步骤：(1)将聚己内酯和磷酸钙混合并制为丝材；(2)按照预设模型，使用所述丝材打印成型得到3D打印多孔支架，所述多孔支架具有孔道结构；(3)将填充浆料注入所述多孔支架的孔道结构中，所述填充浆料含有胶原蛋白和磷酸钙，干燥，获得成型的复合人工骨；(4)将复合人工骨和交联剂进行化学交联，交联后清洗，干燥，获得复合人工骨产品。该复合人工骨具有较优的力学强度，可以有效促进大段骨缺损、骨不连治疗过程中的早期血管及新骨生长。
Absstract of: CN120056235A
本发明涉及通过喷射打印生产牙科修复体的方法、装置和系统。本发明提供一种通过喷射打印来生产牙科修复体100的方法，包括以下步骤：借助于陶瓷浆料喷射打印(S101)牙科修复体的一个或多个层；以及将着色溶液喷射打印(S102)至一个或多个层上。
Absstract of: CN120056314A
本申请涉及一种精确压低前牙的正畸矫治器的制作方法及正畸矫治器，精确压低前牙的正畸矫治器的制作方法包括根据数字化牙颌模型至少确定覆颌数值、覆盖数值和咬合平面，以及根据覆颌数值确定的需求压低量；确定预设覆盖阈值，根据预设覆盖阈值和覆盖数值之间的第一对比结果，确定对应的压低平台类型；确定预设压低量，根据预设压低量和需求压低量的第二对比结果，确定是否执行分阶段压低操作，若执行分阶段压低操作，则确定分阶段压低操作中的每个阶段压低量，分阶段压低量能基于用户交互窗口进行动态调整。不仅可以针对不同覆颌程度的患者提供个性化的矫治方案，还能确保压低量的精确控制，从而避免传统方法中因压低不准导致的反复调整问题。
Absstract of: CN120053114A
本申请公开了一种仿生型种植桥架，属于种植桥架领域。仿生型种植桥架包括种植体和连接体；种植体包括多个，每个种植体适配一个人体常规牙齿形状；多个种植体按人体常规牙齿顺序排列，相邻两个种植体之间通过连接体连接；每个种植体从牙尖至牙根的方向由实体结构向第一多孔结构变化以使弹性模量降低；每个种植体从牙齿中心至边沿的方向通过增加孔隙率使弹性模量降低；通过降低孔隙率使作为切牙、尖牙和磨牙的种植体的牙本质的弹性模量依次增加。本申请在采用同一种材料制作仿生型种植桥架的同时，实现根据人体生理牙齿不同位置具有不同的弹性模量，与人体生理牙齿实际弹性变形情况一致化，具有仿生学设计。
Absstract of: CN120053751A
本发明属于生物材料技术领域，具体涉及一种骨修复用3D打印聚乳酸复合支架及其制备方法。其中，骨修复用3D打印聚乳酸复合支架由以下原料制备而成：PLA/Mg‑ZrO2和BP/STAC；本发明采用PLA/Mg‑ZrO2作为3D打印支架，在PLA/Mg‑ZrO2支架表面形成BP/STAC复合涂层，制备得到骨修复用3D打印聚乳酸复合支架，PLA/Mg‑ZrO2支架具有模仿天然骨骼的分级孔隙率，PLA具有良好的生物相容性，Mg‑ZrO2的加入增强了PLA支架的力学强度和韧性，BP/STAC的复合涂层进一步增强了复合支架的力学性能，且有助于细胞附着和生长，加速了骨细胞的增殖和分化，促进新骨的形成。
Absstract of: WO2024033402A1
The invention relates to a maxillary modeller (2) intended to be worn, in a service position, on a dental arch of a user in order to modify the shape of the palate, the maxillary modeller being one-piece and removable and comprising: - a central palatal portion (22) configured to be in contact with the user's palate when the maxillary modeller is in the service position; and - a first and a second dental portion (24; 26) each comprising at least one, preferably multiple cavities configured to receive teeth of the user when the maxillary modeller is in the service position, the first and second dental portions extending on either side of the central palatal portion, the central palatal portion being configured so as to exert on the palate, in the service position, forces suitable for modifying the shape thereof.
Absstract of: AU2023271390A1
Aspects of the disclosure include a fabrication platform for supporting a bioprinted fiber structures during printing, patterning, and/or processing, comprising a frame with a plurality of posts for securing a cross-linkable fiber during printing thereof, and where a continuous length of the cross-linkable fiber is printed around a plurality of posts during the 3D bioprinting process. The fabrication platform enables the cross-linkable fiber to be suspended during one or more of printing, patterning, and/or processing. In this way, the bioprinted fiber structure comprises a uniform outer surface, and can be easily modified and/or further processed after printing and patterning are completed.
Absstract of: CN119546355A
A biological material comprising a first porous polymer, a second non-porous polymer, and a therapeutic agent, and a method of using the same for treating a condition are disclosed. The biomaterials disclosed herein may be, for example, surgical articles. Implanting the biomaterials disclosed herein in a subject can treat, for example, cancer.
Absstract of: WO2025111433A1
A contrast marker for use in medical imaging comprising: an elongated body comprising a first end and a second end, the second end opposite the first end, wherein a longitudinal axis is defined between the first end and the second end. A first portion of the elongated body is formed of a radiopaque material and a second portion of the elongated body is formed of a polymeric material, the first portion extending in a direction parallel with the longitudinal axis. The marker may be configured to receive a fluidic contrast medium so as to be imageable under CT and MR imaging. Also provided herein are methods of making the contrast marker. Further provided herein is an applicator plug for sealing a tubular brachytherapy applicator.
Absstract of: WO2025111571A1
An apparatus includes a 3D model of a soft tissue. The 3D model includes an anatomically correct outer wall defining an internal cavity. The 3D model further includes a reduced scale duplicate of the outer wall positioned with in the internal cavity. The reduced scale duplicate divides the internal cavity into an inner chamber within the reduced scale duplicate and an outer chamber between the reduced scale duplicate and the outer wall. The 3D model further includes ports extending from each of the inner chamber and the outer chamber to an exterior of the outer wall. Each port is configured to connect to a device that is configured to inject liquids into each of the inner chamber and the outer chamber.
Absstract of: WO2025110384A1
The present invention relates to a composite resin for esthetic restorations with improved antimicrobial properties and polymerization depth, and a manufacturing method therefor, wherein the compositive resin comprises urethane dimethacrylate (UDMA), bisphenol A-glycidyl methacrylate (BIS-GMA), bisphenol A dimethacrylate ethoxylated (BIS-EMA), triethylene glycol dimethacrylate (TEGDMA), a photoinitiator, a co-photoinitiator, a filler, barium glass, an accelerator, an antioxidant, a discoloration inhibitor, and an antimicrobial agent in addition to lysozyme. With the enhanced polymerization depth, the resin can be applied as a bulk-fill resin, and the excellent antimicrobial properties thereof provide resistance against bacteria and viruses. After polymerization, the resin exhibits a flexural strength exceeding 80 MPa, which is a level required by the Korean Ministry of Food and Drug Safety.
Absstract of: WO2025107170A1
Disclosed are a bio-ink for promoting microangiogenesis, a method for preparing same, and use thereof. The bio-ink is prepared by the following method: 1) preparing a filamentous microgel with a diameter within 20 microns from a sacrificial-phase material A as a porogenic template; 2) seeding vascular endothelial cells and perivascular cells on the surface of the filamentous microgel to give a hydrogel microfilament with the surface loaded with cells; and 3) mixing the hydrogel microfilament with the surface loaded with cells with a solution of a matrix-phase material B to give the bio-ink for promoting microangiogenesis. The bioprinting using the bio-ink can construct a capillary-like structure and cross-scale microvessels. The present invention can achieve the preparation of a micro-channel porous hydrogel structure with an average diameter of 20 microns or less and controllable porosity and the formation of a capillary-like network structure.
Absstract of: CN222917965U
本实用新型涉及一种负压微针给药装置，包括：壳体，壳体的顶部设置有注射器接口，注射器接口用于连接外部的注射器；壳体的底部设置有凹槽和凸起，凸起用于和皮肤贴合；壳体的内部设置有储药腔体和负压腔体，储药腔体和注射器接口连通；壳体的表面设置有负压接口，负压腔体的一端通过负压接口和外部的抽负压装置连接；凹槽的表面设置有通孔，负压腔体的另一端通过通孔和外部连通；微针，包括针头和中空的流道，流道设置在针头的内部，流道和储药腔体连通，针头凸出于凹槽的表面向外延伸，针头用于刺破皮肤。本实用新型可以有效地吸引皮肤靠近针头并自动刺破皮肤给药，提高了给药效果和患者的使用体验。
Absstract of: US2024131795A1
Systems, methods, and devices for computer-aided design, digital treatment planning, and direct additive manufacturing of dental appliances are provided. In some embodiments, a method includes receiving a treatment plan for a patient's teeth, the treatment plan specifying a target arrangement for the teeth and a plurality of treatment stages to reposition the teeth from an initial arrangement toward the target arrangement. The method can include identifying appliance design parameters for one or more dental appliances to implement at least one treatment stage of the plurality of treatment stages. The appliance design parameters can include one or more manufacturability parameters corresponding to an additive manufacturing process to be used to directly fabricate the one or more dental appliances. The method can further include determining an appliance geometry for the one or more dental appliances using the set of appliance design parameters.
Absstract of: CN120053115A
本申请公开一种高适配的根形种植体，涉及牙种植体技术领域，包括：根形种植体；根形种植体的外形完全贴合拔牙窝；根形种植体的顶部开设有向内的凹槽；凹槽用于固定中央螺栓和义齿种植基台；根形种植体是基于目标口腔CT数据，采用3D打印制作；目标口腔CT数据为拔牙窝处的CT数据；凹槽是基于义齿种植基台和中央螺栓的底部形态，采用机件加工在根形种植体上制备。本申请中根形种植体能够适配安装不同类型的中心螺栓和义齿种植基台，同时该根形种植体的应用也能有效地缩短牙种植手术的周期时间。
Absstract of: CN120053764A
本发明涉及软骨‑骨一体化类器官及其制备方法。所述软骨‑骨一体化类器官包括仿骨层与仿软骨层，所述仿骨层由基于压电水凝胶构建的仿骨基质力响应性生物墨水打印而成，所述仿软骨层由基于压电水凝胶构建的仿软骨基质力响应性生物墨水打印而成。本发明将压电材料与生物墨水相结合，利用3D生物打印技术精确构建软骨层和骨层的双生态位结构。通过压电材料将机械力转化为生物电信号，从而促进细胞活动和组织再生。同时，3D生物打印技术实现精确的结构控制，为关节软骨缺损修复提供了一种全新的策略。
Nº publicación: CN120056233A 30/05/2025
Applicant:
义获嘉伟瓦登特公司
Absstract of: CN120056233A
本发明涉及通过喷射打印生产牙科修复体的方法、装置和系统。本发明提供一种通过喷射打印来生产牙科修复体的方法，包括以下步骤：借助于陶瓷浆料喷射打印(S101)牙科修复体的一个或多个层；将着色溶液喷射打印(S102)至一个或多个层上；以及施加(S103)用于固定着色溶液的固定溶液。
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