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Solicitudes publicadas en los últimos 30 días / Applications published in the last 30 days
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用于微导管塑形的方法及相关产品

Publication No.:  CN121515465A 13/02/2026
Applicant: 
强联智创(北京)科技有限公司
CN_121515465_PA

Absstract of: CN121515465A

本申请公开了一种用于微导管塑形的方法及相关产品,其中所述方法包括:控制塑形指对塑形丝实施塑形,以将所述塑形丝塑造成目标形状;在塑形过程中,对所述塑形嘴、所述塑形指以及所述塑形丝之间进行碰撞检测;根据碰撞检测结果确定相应的碰撞处理操作。通过本申请方法能够及时检测出碰撞并处理,进而避免造成不可逆的塑形错误。

一种光固化生物墨水及其制备方法和应用

Publication No.:  CN121513271A 13/02/2026
Applicant: 
崂山国家实验室
CN_121513271_PA

Absstract of: CN121513271A

本发明涉及一种光固化生物墨水及其制备方法和应用,属于生物材料及组织工程技术领域。该光固化生物墨水包括甲基丙烯酰化鱼鳞明胶和光引发剂,其中,甲基丙烯酰化鱼鳞明胶由鱼鳞明胶与甲基丙烯酸酐通过酰化反应制得,甲基丙烯酰化鱼鳞明胶的取代度为30%~55%。该光固化生物墨水兼具快速光固化、低免疫原性、低脂肪含量及优良生物相容性,特别适用于软骨、皮肤、血管等精细组织工程支架和类器官的3D生物打印构建。

负载生长因子的双层GelMA-AlgMA功能性水凝胶支架的制备及其应用

Publication No.:  CN121513272A 13/02/2026
Applicant: 
深圳市第二人民医院(深圳市转化医学研究院)
CN_121513272_PA

Absstract of: CN121513272A

本发明公开了负载生长因子的双层GelMA‑AlgMA功能性水凝胶支架的制备及其应用。包括以下步骤:制备复合KGN的GelMA水凝胶前体溶液;制备复合 BMP‑2的AlgMA水凝胶前体溶液;3D打印。本发明的有益效果在于:将复合KGN的GelMA和复合 BMP‑2的AlgMA结合为双层支架,KGN促进软骨形成,BMP‑2促进骨形成,生长因子针对性地释放,针对骨软骨界面的不同组织层进行特异性修复。

一种肩关节抗生素间隔器的制备方法

Publication No.:  CN121515462A 13/02/2026
Applicant: 
广东省中医院珠海医院
CN_121515462_A

Absstract of: CN121515462A

本发明涉及医学辅助工具的制备方法,尤其涉及一种肩关节抗生素间隔器的制备方法。它包括以下步骤,A、将健侧的CT扫描数据输入3D软件得健侧的肱骨全长3D模型,健侧模通过镜像制作“患侧”正常肱骨全长3D模型得纠正模;B、通过纠正模数据确认肩关节抗生素间隔器模型:C、制作肩关节抗生素间隔器模具并通过3D打印机打印出肩关节抗生素间隔器模具;D、在肩关节抗生素间隔器模具的上模腔和下模腔中填充满骨水泥后合膜直至骨水泥完全固化,得肩关节抗生素间隔器。本发明所得肩关节抗生素间隔器更加美观和精准,从而更好维持软组织张力、适应上臂长度,它与感染切除后缺损骨结构匹配和接触,为间隔期肱骨截骨后需修复结构提供更好稳定性。

一种硬组织修复材料及其制备方法

Publication No.:  CN121513265A 13/02/2026
Applicant: 
中国医科大学
CN_121513265_PA

Absstract of: CN121513265A

本发明公开了一种硬组织修复材料及其制备方法。其中硬组织修复材料主要由无机钙盐和光固化高分子材料组成。特别涉及一种含寡聚磷酸钙(CPO)的聚乙二醇二丙烯酸酯(PEGDA)水凝胶材料及其制备方法。首次将CPO与PEGDA以一定比例复合,使用光引发剂(LAP或I2959),制备出机械强度较高、生物相容性优良的可注射水凝胶材料。利用模具法或三维(3D)打印技术进一步将水凝胶材料加工形成不同形状的立体结构,用于临床硬组织(如骨组织、牙组织)缺损修复。该材料具有适应性强、安全系数高、使用方便快捷、应用前景广阔等特点。

VALVE ASSEMBLY FOR MEDICAL PROCEDURES

Publication No.:  US20260041901A1 12/02/2026
Applicant: 
W L GORE & ASS INC [US]
W. L. Gore & Associates, Inc
US_20260041901_PA

Absstract of: US20260041901A1

The invention relates to a valve used in medical procedures. More specifically the invention relates to an introducer sheath valve used in minimally invasive and conventional surgical procedures. The valve may accommodate a wide range of surgical implement diameters, shapes, and multiple implements without imposing the high frictional forces of known valves.

IMPLANTS COMPRISING A SILICONE FOAM

Publication No.:  US20260041814A1 12/02/2026
Applicant: 
ELKEM SILICONES USA CORP [US]
Elkem Silicones USA Corp
US_20260041814_A1

Absstract of: US20260041814A1

The present invention relates to new implants, especially breast implants, which are bio-durable, biocompatible, which provide a soft tissue feel, and having a reduced density. Said implants comprise a shell and a filling enclosed by the shell, wherein the filling comprises a silicone foam obtained from a blowable crosslinkable silicone composition comprising an organopolysiloxane having at least two alkenyl groups bonded to silicon per molecule, an organosilicon compound having at least two and preferably at least three hydrogen atoms bonded to silicon per molecule, a hydrosilylation catalyst, at least one porogenic agent which is water, hydrogel, or an aqueous silicone emulsion, at least one chemical blowing agent, and a linear polydimethylsiloxane.

METHOD OF MANUFACTURING DIABETIC FOOT PATIENT-SPECIFIC DERMAL REGENERATION SHEET AND DIABETIC FOOT PATIENT-SPECIFIC DERMAL REGENERATION SHEET MANUFACTURED USING THE SAME

Publication No.:  US20260041717A1 12/02/2026
Applicant: 
ROKIT HEALTHCARE INC [KR]
ROKIT HEALTHCARE INC
US_20260041717_PA

Absstract of: US20260041717A1

The specification relates to a method of manufacturing a diabetic foot patient-specific skin regeneration sheet, and a diabetic foot patient-specific skin regeneration sheet. The method includes extracting autologous adipose tissue, removing fibers in the autologous adipose tissue, crushing the autologous adipose tissue, and acquiring an adipose tissue extract by filtrating the crushed autologous adipose tissue.

BIOENGINEERING PATIENT-SPECIFIC 3D-PRINTED CARTILAGE IMPLANTS

Publication No.:  US20260041558A1 12/02/2026
Applicant: 
SHEBA IMPACT LTD [IL]
TECHNION RES & DEVELOPMENT FOUNDATION LIMITED [IL]
Sheba Impact Ltd,
Technion Research & Development Foundation Limited
US_20260041558_PA

Absstract of: US20260041558A1

The invention related to an implant comprising a scaffold comprising at least one first area characterized by micropores and at least one second area characterized by macropores, wherein said at least one second area is defined by being expected to be exposed to higher pressures and/or forces when compared with said at least one first area, and methods thereof.

Additive Manufacturing Part Support and Handling Frame

Publication No.:  US20260041436A1 12/02/2026
Applicant: 
HOWMEDICA OSTEONICS CORP [US]
Howmedica Osteonics Corp
US_20260041436_PA

Absstract of: US20260041436A1

A cutting instrument including an insert and a frame having sidewalls that extend from a base and define a slot. The slot is configured to receive a portion of the insert such that an edge of the insert extends beyond the frame. The sidewalls are configured to shrink around a portion of the insert such that an edge of the insert extends beyond the frame. Additionally, a method for fabricating a cutting instrument including depositing layers of metal powder onto a base and selectively binding the deposited layers of the metal powder onto the base to form a frame attached to the base. Next, placing an insert within the frame such that a portion of the insert extends beyond the frame and the combination of the base, the frame, and the insert forms an in-process assembly.

Breath-Enhanced Jet Nebulizer for HFNC Therapy

Publication No.:  US20260041860A1 12/02/2026
Applicant: 
THE RESEARCH FOUNDATION FOR THE STATE UNIV OF NEW YORK [US]
THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK
US_20260041860_PA

Absstract of: US20260041860A1

A system and method for enhanced aerosol drug delivery during high flow nasal cannula (HFNC) therapy. The system comprises a breath enhanced jet nebulizer (BEJN) connected to a high flow medical breathing gas supply supplying breathing gas to the BEJN at flow rates of 5 L/min to 60 L/min, a nebulization gas supply, a drug infusion device that supplies a drug solution to the nebulizer for the delivery of nebulized drug to a patient. All the breathing gas and nebulized drug solution delivered to the patient passes through the BEJN. The rate of drug delivery increases with increases in the flow rate of the medical breathing gas supply and increases in infusion pump flow rates. The drug solution infusion rate is between 5 mL/hour and 50 mL/hour. This system and method enable efficient aerosol drug delivery to patients during HFNC therapy for prolonged periods, improving treatment outcomes.

THREE-DIMENSIONAL RECONSTRUCTION METHOD, ELECTRONIC DEVICE AND STORAGE MEDIUM

Publication No.:  US20260045040A1 12/02/2026
Applicant: 
SHINING 3D TECH CO LTD [CN]
Shining 3D Tech Co., Ltd
US_20260045040_PA

Absstract of: US20260045040A1

The present application provides a three-dimensional reconstruction method, an electronic device and a storage medium, the method includes obtaining a first image frame set of an oral cavity in a first state, where the oral cavity in the first state indicates that at least one actual scan body is installed in the oral cavity. A scan body area of each image frame in the first image frame set is identified. Once multiple image frames in the first image frame set are spliced and constructed based on feature information of the scan body area, the target three-dimensional data corresponding to the actual scan body in the oral cavity is obtained.

SYSTEMS AND METHODS FOR SELECTIVE SHAPE TRANSFORMATION OF 3D-PRINTED MATERIALS

Publication No.:  US20260042889A1 12/02/2026
Applicant: 
UNIV OF WASHINGTON [US]
ASOCIACION CENTRO DE INVESTIG COOPERATIVA EN BIOMATERIALES CIC BIOMAGUNE [ES]
UNIV OF THE BASQUE COUNTRY UPV/EHU [ES]
University of Washington,
ASOCIACI\u00D3N CENTRO DE INVESTIGACI\u00D3N COOPERATIVA EN BIOMATERIALES - CIC BIOMAGUNE,
UNIVERSITY OF THE BASQUE COUNTRY, UPV/EHU
US_20260042889_PA

Absstract of: US20260042889A1

Shape-restoring materials, as well as techniques for generating shape-restoring materials, are described. An example method includes generating a construct by exposing, to UV-visible light, a resin comprising a globular protein, a water-soluble co-monomer, light-to-heat converting nanoparticles, water, and a photoinitiator. At least a portion of the water is removed from the construct. The construct is converted from a first shape to a second shape by applying a force to the construct. The construct is reverted to the first shape in response to being exposed to NIR light, due to the absorption of the NIR light by the nanoparticles.

THREE-DIMENSIONAL IMPLANT WITH HYDROPHILIC SURFACE

Publication No.:  AU2024289833A1 12/02/2026
Applicant: 
BELLASENO GMBH
BELLASENO GMBH
AU_2024289833_A1

Absstract of: AU2024289833A1

The disclosure provides a 3D tissue reconstruction implant having a hydrophilic implant surface and consisting of a bio-resorbable material, wherein the implant surface is considered hydrophilic when assessed using an ink test following ISO 8296:2003 and adapted to a 3D surface, wherein said ink test comprises incubating the implant for 1 min in a solution consisting of an ink with a surface tension of 72 mN/m and water and wherein after incubation of the implant in said solution an ink colored implant surface is indicative for a hydrophilic implant surface. The disclosure also provides said implant for use in tissue reconstruction, (soft) tissue support, tissue augmentation and/or implant revision and the use of said implant for reconstructing, augmenting and/or revising a tissue and/or supporting a (soft) tissue, respectively, wherein the implant is inserted into a patient. Further the disclosure provides a method of manufacturing a tissue reconstruction implant with a hydrophilic implant surface.

SHAPE MEMORY POLYMER-BASED DEVICES AND METHODS OF USE IN TREATING INTRACORPOREAL DEFECTS

Publication No.:  US20260041435A1 12/02/2026
Applicant: 
THE BOARD OF REGENTS OF THE UNIV OF OKLAHOMA [US]
The Board of Regents of the University of Oklahoma
US_20260041435_PA

Absstract of: US20260041435A1

A novel shape memory polymer (SMP)-based device for surgical treatment of an intracorporeal defect (e.g., a void or anomaly) such as an intracranial aneurysm or fistula. In at least one non-limiting embodiment, the SMP device is a 3D-printed SMP material sized to specifically fit and thus occlude an intracranial aneurysm (ICA). The SMP device may be delivered to the intracorporeal defect via a catheter having a heating mechanism wherein the SMP device is raised above its glass transition temperature as it is deployed, causing the SMP device to return to its permanent shape after it is deployed into the intracorporeal defect. SMP device delivery systems that include the SMP devices, as well as methods of making and using the devices and systems, are also disclosed.

ORTHODONTIC BRACKET AND BRACKET SUPPORT SYSTEM AND METHOD

Publication No.:  US20260041526A1 12/02/2026
Applicant: 
SPRINTRAY INC [US]
SprintRay Inc
US_20260041526_PA

Absstract of: US20260041526A1

An orthodontic bracket and bracket support system, and its method of manufacture and use is provided. The system includes a bracket assembly including one or more bracket members to be bonded to a patient's teeth, a placement guide assembly including one or more placement members to properly position the bracket members for the bonding procedure, and a support assembly to support the bracket assembly and/or the placement guide assembly during manufacture and use. The bracket assembly, the placement guide assembly, and the support assembly are formed together and in combination using stereolithography three-dimensional (3D) printing.

DENTAL RESTORATION MOLDS

Publication No.:  US20260041530A1 12/02/2026
Applicant: 
SOLVENTUM INTELLECTUAL PROPERTIES COMPANY [US]
Solventum Intellectual Properties Company
US_20260041530_PA

Absstract of: US20260041530A1

A custom tool for forming a dental restoration in a patient's mouth includes a facial mold body and a lingual mold body, each configured for a patient-specific, customized fit with respective sides of at least one tooth. The facial and lingual mold bodies each include restorative portions and engagement portions that interlock at locations offset from a mold cavity formed between the restorative portions. The engagement portions are dimensioned to produce a residual seating pressure that maintains the mold bodies in a clamped state when interlocked, facilitating accurate shaping of restoration material within the mold cavity. The tool may include apertures for injection of restorative material, hinged doors or plugs for sealing, and vents for controlling material flow. The device and associated methods enable the digital design and fabrication of custom dental restoration molds for single or multiple teeth, improving restoration quality and reducing overall clinical or procedural complexity.

FABRICATION METHOD AND SYSTEM FOR LPBF MAGNESIUM-ALLOY TISSUE-ENGINEERING SCAFFOLD WITH SMOOTH INNER SURFACE

Publication No.:  WO2026031699A1 12/02/2026
Applicant: 
SHANGHAI JIAO TONG UNIV [CN]
\u4E0A\u6D77\u4EA4\u901A\u5927\u5B66
WO_2026031699_PA

Absstract of: WO2026031699A1

Provided in the present invention are a fabrication method and system for an LPBF magnesium-alloy tissue-engineering scaffold with a smooth inner surface. The method comprises: step S1, scanning a porous scaffold, and performing screening to obtain infill scanning parameters, which can achieve the greatest density, wherein the scanning comprises single-pass contour scanning and single infill scanning; step S2, on the basis of said infill scanning parameters, optimizing a contour scanning strategy; step S3, acquiring a corresponding molten-pool size, and using the optimized contour scanning strategy to adjust a spot compensation value; and step S4, on the basis of the contour scanning strategy and the adjusted spot compensation value, fabricating a magnesium-alloy tissue-engineering scaffold. In the present invention, the defects of powder adhesion and dross formation in a complex porous structure which seriously affect the inner surface roughness and the scaffold performance are eliminate in situ during fabrication, such that the fluidity, fatigue resistance and corrosion resistance of a porous scaffold are improved, cumbersome post-processing procedures are simplified, and the production cost is reduced, thereby achieving the concept of green production.

NEGATIVE POISSON'S RATIO MATERIALS FOR THERMAL AND RADIATION THERAPY SEEDS

Publication No.:  US20260041923A1 12/02/2026
Applicant: 
PARK JOON BU [US]
Park Joon Bu
US_20260041923_PA

Absstract of: US20260041923A1

A biocompatible seed for implantation in tissue of a patient includes an elongated body sized and shaped to be at least partially inserted into the tissue of the patient, in which the body includes a negative Poisson's ratio (NPR) material having a Poisson's ratio of between 0 and −1. The seed can be a thermal seed configured to generate heat responsive to exposure to a magnetic field. The seed can be a seed for brachytherapy that includes an inner layer including a radioactive material and an outer layer including the NPR material.

TECHNIQUES FOR AUTOMATED MARKING OF DENTAL APPLIANCES

Publication No.:  EP4688439A1 11/02/2026
Applicant: 
STRAUMANN INST AG [CH]
Institut Straumann AG
CN_121219140_PA

Absstract of: MX2025011659A

The present disclosure discusses techniques for marking a dental appliance. A dental model and dental appliance are positioned onto a conveyor tray, which is transported to a scan station. The dental model and conveyor tray each include an identifying code. The scan station includes a camera and barcode reader to read the identifying codes on the dental model and conveyor tray, and these codes are associated with one another. The conveyor tray then moves to a marking station where a barcode reader reads the code on the conveyor tray, and then marks the dental appliance with the appropriate marking.

AUTOMATIC DESIGN OF CUSTOM EAR DEVICES

Publication No.:  EP4689980A1 11/02/2026
Applicant: 
3SHAPE AS [DK]
3Shape A/S
CN_121079687_PA

Absstract of: WO2024200441A1

Described herein is a computer-implemented method for constructing in the form of designing in a virtual environment a custom ear device in an automated process utilizing a trained neural network. The computer-implemented method described is configured to allow for changing the output form the neural network to create change to an automatic generated custom ear device design. Furthermore, described herein is a system utilizing a processor running the method described herein to automatically generate virtually constructed custom ear devices that may be modified to adjust for any incorrect outputs generated by a neural network.

SPINAL IMPLANTS WITH CUSTOM DENSITY AND 3-D PRINTING OF SPINAL IMPLANTS

Publication No.:  EP4691507A2 11/02/2026
Applicant: 
VB SPINE US OPCO LLC [US]
VB SPINE US OPCO LLC
EP_4691507_A2

Absstract of: EP4691507A2

In some embodiments, a spinal implant (10, 110, 210, 310, 400) is provided and includes a body portion defining a longitudinal axis. The body portion includes a distal end portion, a proximal end portion, opposed side surfaces that extend between the distal and proximal end portions, and top and bottom surfaces configured and adapted to engage vertebral bodies. The top and bottom surfaces have a surface roughness between 3-4 µm. A cavity extends through the top and bottom surfaces defining a surface area that is at least 25% of a surface area of the top surface or the bottom surface. First orifices (24, 124, 224, 324, 426a) are defined through the top surface and second orifices (34, 134, 234, 334, 426b) are defined through the bottom surface. The second orifices are connected to the first orifices by a plurality of channels.

ADDITIVE MANUFACTURING PART SUPPORT AND HANDLING FRAME

Publication No.:  EP4691381A1 11/02/2026
Applicant: 
HOWMEDICA OSTEONICS CORP [US]
Howmedica Osteonics Corp
EP_4691381_PA

Absstract of: EP4691381A1

A cutting instrument including an insert and a frame having sidewalls that extend from a base and define a slot. The slot is configured to receive a portion of the insert such that an edge of the insert extends beyond the frame. The sidewalls are configured to shrink around a portion of the insert such that an edge of the insert extends beyond the frame. Additionally, a method for fabricating a cutting instrument including depositing layers of metal powder onto a base and selectively binding the deposited layers of the metal powder onto the base to form a frame attached to the base. Next, placing an insert within the frame such that a portion of the insert extends beyond the frame and the combination of the base, the frame, and the insert forms an in-process assembly.

INVERTED CONTACT-AIDED ROLLING ELEMENT MECHANISMS AND DEVICES

Publication No.:  EP4689429A1 11/02/2026
Applicant: 
33 MEDICAL INC [US]
33 Medical, Inc
WO_2024211902_PA

Absstract of: WO2024211902A1

Inverted contact-aided rolling element mechanisms and devices are discussed herein. In various embodiments, the contact-aided compliant mechanism includes a first rigid component, a second rigid component, a first flexible component, a second flexible component, each of the first and second flexible components comprising a first end, a second end, and a third end, and the first and second flexible components disposed between the first and second rigid components.

IMPLANT

Nº publicación: EP4688022A1 11/02/2026

Applicant:

JAGE RES & INNOVATIONS PTY LTD [ZA]
Jage Research & Innovations (Pty) Ltd

CN_121219029_PA

Absstract of: AU2024241734A1

This invention relates to an implant (10), including a support arrangement (12) manufactured from a form of a porous material, for receiving and supporting stem cells (14) in a supported condition, for receiving a medium in the form of a neural basal and neural induction medium mixture (20) and the support arrangement (12) being shaped and sized to conform to and be received complementally by an implant zone (16). The implant zone (16) being a space defined by an excised portion of a subject's spinal cord (18). The neural basal and neural induction medium mixture (20) provides nutrients for the development of the stem cells (14) and the growth factors, in form of neurotrophin 3, neurotrophin 4 and brain-derived neurotrophic factor (BDNF) encourage and control development of the stem cells (14), the growth factors typically being constituents of the medium mixture (20).

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