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369
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Updated on
16/02/2026 [06:57:00]
Results 125 to 150 of 369
Absstract of: CN121466289A
一种铁铜双原子纳米酶的制备方法及应用，它涉及一种纳米酶的制备方法及应用。本发明为了解决传统治疗手段虽然提高了患者生存率，但其临床应用常常受到严重的全身毒性、耐药性以及肿瘤复发的限制与挑战的问题。本发明的步骤包括：步骤1、将二甲基咪唑溶解于无水甲醇中并进行搅拌获得溶液A；步骤2、将六水合硝酸锌、柠檬酸铁铵、乙酰丙酮铜溶解于无水甲醇中并搅拌获得B溶液；步骤3、将溶液A和溶液B混合搅拌后经离心、洗涤、干燥后获得白色样品ZIF‑8；步骤4、将白色样品ZIF‑8在900℃热解得到黑色粉末即为铁铜双原子纳米酶。本发明属于活性氧介导的肿瘤治疗技术领域。
Absstract of: CN121466031A
本发明属于生物制药技术领域，具体涉及一种肠道靶向型尿石素A水溶性递送系统及其制备方法和应用。所述肠道靶向型尿石素A水溶性递送系统是将硝酸锌‑聚乙烯吡咯烷酮的水溶液与2‑甲基咪唑‑尿石素A的甲醇溶液分别超声后，再进行混合搅拌，得到负载有尿石素A的ZIF‑8；在负载有尿石素A的ZIF‑8分散液中滴加羧甲基β葡聚糖溶液后，加入CaCl2后，在表面包裹一层甲基β葡聚糖修饰层得到。本发明构建的保护‑靶向‑增效一体化递送体系，解决UA稳定性低、靶向性差和生物利用度不足等问题。
Absstract of: AU2024261346A1
The current invention relates to a delivery system to deliver one or more cargo to one or more cells, wherein the cargo delivery system comprises at least a calixarene, a phospholipid, an additional lipid such as sterol. The invention further relates to a method of delivering cargo to a subject using the delivery system and a pharmaceutical composition comprising the delivery system. The invention also relates to the use of a calixarene in an immunogenic composition, wherein said composition comprises an immunogenic component encapsulated in a lipid nanoparticle (LNP) comprising said calixarene and wherein said LNP has an adjuvant effect in said immunogenic composition. The invention also relates to a vaccine, wherein said vaccine comprises an immunogenic component encapsulated in a lipid nanoparticle, wherein said lipid nanoparticle comprises at least one calixarene molecule and said lipid nanoparticle acts as an adjuvant in said vaccine. The invention also relates to a method of preparing an immunogenic composition and a composition comprising a lipid nanoparticle (LNP) adjuvant comprising calixarene.
Absstract of: CN121466034A
本发明属于微型机器人技术领域，具体为一种脉冲激光响应性胶体体微纳米机器人及其制备方法与应用，该微纳米机器人为球形结构，由内至外包括核心层和功能层，功能层包覆核心层；核心层为热响应性相变材料，功能层为贵金属纳米材料，功能层的贵金属纳米材料能够吸收并转化近红外脉冲激光为热，使得核心层发生相变，驱动该微纳米机器人实现步进运动并穿透物理屏障。通过高能超声机械乳化、化学还原等步骤制备得到微纳米机器人。该微纳米机器人可作为通用载体，用于化疗药物、基因药物或光热治疗剂的负载，为肿瘤深部递送、血脑屏障穿透等实现“屏障穿透‑靶向给药‑协同治疗”一体化功能，为脑胶质瘤等疾病的诊疗等提供全新技术路径。
Absstract of: AU2024251515A1
The present application relates to lipid nanoparticles containing a steroid compound, and the preparation and a use of the lipid nanoparticles. The lipid nanoparticles can be used to deliver effective loads (such as a nucleic acid) into non-liver organs such as the spleen for the treatment or prevention of certain diseases or conditions, particularly spleen-associated diseases.
Absstract of: WO2024245590A1
The invention relates to a composition comprising a cold-water insoluble crosslinked dextrin and a compound selected from 1-decanoyl-rac-glycerol and carboxymethyl cellulose. This invention also relates to a method for making such composition. The invention also relates to the use of a combination of a cold-water insoluble crosslinked dextrin and of a compound selected from 1-decanoyl-rac-glycerol and carboxymethyl cellulose, for increasing the epithelial permeation of an active ingredient, or for the epithelial delivery of an active ingredient.
Absstract of: CN121466109A
本发明公开了一种人工线粒体及其制备方法和应用，所述人工线粒体包括高分子纳米颗粒和磷酸肌酸，所述人工线粒体是高分子纳米颗粒通过物理共混或化学键合的方式负载磷酸肌酸。本发明制备的人工线粒体可以通过修复细胞的磷酸肌酸‑肌酸激酶能量穿梭系统而为细胞提供能量，其主要过程包括人工线粒体进入细胞后，会释放其中的磷酸肌酸，与细胞质中的ADP反应产生ATP。本发明制备人工线粒体有望为体内提供能量。
Absstract of: CN121466035A
本申请公开了一种负载鬼臼毒素的纳米药物、制备方法及应用，该纳米药物为核壳结构，以卵磷脂包载鬼臼毒素形成疏水核心，表面包覆改性壳聚糖作为壳层。其制备方法是将卵磷脂和鬼臼毒素的乙醇溶液注入改性壳聚糖的醋酸水溶液中，经孵育、离心后获得，制备工艺简便。通过本申请制得的纳米药物能够显著提高鬼臼毒素的水溶性与稳定性，并利用改性壳聚糖的免疫佐剂功能，在实现高效化疗的同时激活机体抗肿瘤免疫应答，产生协同治疗效应，对实体瘤具有优异的抑制效果。
Absstract of: CN121466269A
本发明涉及药物技术领域，具体涉及药物组合物、纳米颗粒及其制备方法和应用。本发明发现维生素B6和B12通过结合膜蛋白激活该信号通路，通过PLP1蛋白的过表达来抑制神经炎症。进一步的，本发明提供了采用维生素B6、维生素B12和PLP1蛋白三种组分的药物组合物，各组分之间相互配合，协同增效，且兼容性强，能够有效减缓神经元损伤。采用该药物组合物制备获得的纳米颗粒进一步维持药物疗效，节约成本。针对生物利用率低的问题，采用鼻腔吸入，离作用地点距离更近，防止了肝门静脉循环对于药物的消耗；并且鼻腔吸入的维生素B6和B12在熊果酸的包裹下可以直接穿过血脑屏障，不存在因水溶性而无法穿过血脑屏障的问题。
Absstract of: CN121466003A
本发明公开了一种双模块递送系统及其在制备治疗骨关节炎或滑膜炎的药物中的应用；包括关节腔给药的模块1和模块2，所述模块1为包裹衰老细胞清除剂的纳米粒或外泌体或微球，所述模块2为包裹M2极化诱导剂的纳米粒或外泌体或微球；本发明应用于骨关节炎或滑膜炎的治疗药物中，能够靶向衰老滑膜成纤维细胞与M1巨噬细胞，将衰老细胞清除与巨噬细胞重编程机制结合，同时解决了衰老相关分泌表型的产生和巨噬细胞炎性极化问题，通过同时减少SASP源和炎症反应打破衰老‑炎症级联反应的恶性循环，恢复关节内环境的稳定，具有极强的应用前景。
Absstract of: CN120676962A
Disclosed herein are RSV F glycoproteins and nanoparticles comprising the glycoproteins suitable for use in vaccines. The nanoparticles present antigens from pathogens surrounding and associated with the detergent core, resulting in enhanced stability and good immunogenicity. Doses, formulations, and methods for preparing the vaccines and nanoparticles are also disclosed.
Absstract of: AU2024327040A1
A method for preparing nucleic acid-containing lipid nanoparticles (NALNP) from a nucleic acid-containing neutral pH ionic salt solution and a lipid solution is provided. The method includes combining the nucleic acid-containing neutral pH ionic salt solution and the lipid solution and forming a combined mixture. The method further includes introducing an aqueous solution of lower ionic concentration than that of the neutral pH ionic salt solution into the combined mixture, thereby creating an ionic flux and forming the nucleic acid-containing lipid nanoparticles (NALNP).
Absstract of: WO2026025194A1
Provided here are compositions for delivery of leptin to a cell. The compositions can comprise a proteo-lipid vehicle comprising a recombinant fusion-associated small transmembrane (FAST) polypeptide and a nucleic acid encoding leptin or a functional fragment thereof. Also provided are methods for using the compositions.
Absstract of: AU2024314343A1
Disclosed are a method for preparing intracellular-derived nanovesicles and the use of the nanovesicles, in particular the use of the nanovesicles as a drug carrier and in the treatment of ophthalmic diseases. Intracellular-derived nanovesicles can be efficiently enriched using the method. The obtained intracellular nanovesicles, compared with small extracellular vesicles that are isolated from a cell supernatant and are mainly composed of exosomes, have different lipid, protein and nucleic acid components, have a higher yield, a smaller particle size, and a narrow particle size distribution range, and are more stable at different temperatures. The intracellular nanovesicles have a higher encapsulation efficiency and drug loading rate as a drug-loading carrier, and are more easily absorbed by tissue during in vivo administration, for example, the loaded drug administered in the form of an intravitreal injection can be absorbed by the retina more quickly. The intracellular nanovesicles can not only improve corneal injuries caused by wounds and alkali burns, but can also improve retinal damage and denaturation, and have very good application and research values in the pharmaceutical field.
Absstract of: AU2024315222A1
The present disclosure provides a compound of formula (I): (I), or a pharmaceutically acceptable salt thereof, that is useful for forming particles (e.g., lipid nanoparticles) for delivery of nucleic acids. The present disclosure further provides particle compositions comprising the compound of formula I, as well as uses thereof.
Absstract of: AU2023455215A1
Provided herein are novel constructs comprising gold nanoparticles bound to two types of cytokines, wherein the two types of cytokines comprise Tumor Necrosis Factor alpha (TNF ) and a cytokine selected from the group consisting of Interferon gamma (IFN ) and lnterleukin-12. Further provided is a method for treating cancer in a subject in need thereof.
Absstract of: WO2026029040A1
The purpose of the present invention is to provide: lipid nanoparticles which have excellent endosome desorption capability; and an amino lipid which can be used for the lipid nanoparticles. The present invention includes an amino lipid having a structure represented by formula (1). "In formula (1), R1 and R2 each independently represent an alkyl group having 1 to 6 carbon atoms, or an arbitrary carbon atom in R1 and an arbitrary carbon atom in R2 may be bonded to each other to form a hetero ring containing a nitrogen atom; and R3 and R4 each independently represent an aliphatic hydrocarbon group which has 1 to 35 carbon atoms and can be substituted with a substituent group α; wherein at least one of R3 and R4 represents an aliphatic hydrocarbon group which has 5 to 35 carbon atoms and can be substituted with the substituent group α, and the substituent group α includes a hydroxyl group, an alkoxy group, a sulfanyl group, an alkylthio group, and an alkoxycarbonyl group."
Absstract of: WO2026026965A1
This application provides an anti-Claudin18.2 nanobody, a chimeric antigen receptor, and uses thereof. This application provides a nanobody or antigen-binding fragment thereof that specifically binds to Claudin18.2, a chimeric antigen receptor, a host cell, an immunoconjugate, a pharmaceutical composition, a kit, and a related method and related uses.
Absstract of: US20260035336A1
The present invention relates in part to novel cationic lipids and their use, e.g., in delivering nucleic acids to cells.
Absstract of: US20260035410A1
Described herein are TIGIT binding peptides, nanoparticle systems such as dendrimer systems including the TIGIT binding peptides, pharmaceutical formulations, and methods of use. Also described are methods of identifying peptides that bind a target receptor, the method including phage display, chemical synthesis, determination of binding affinities, and computational modeling. Advantageously, adaptive evolution modeling can be used to optimize the peptides identified in the methods for improved binding affinities.
Absstract of: US20260035369A1
The present application relates to a vincamine derivative, a preparation method therefor, and use thereof, and belongs to the technical field of preparation of vincamine derivatives. The vincamine derivative has the following advantages: (i) Modification of the tail chain increases the lipid solubility of vincamine compounds without affecting the cerebral blood flow regulation of vincamine itself, thereby helping the carried drug penetrate the blood-brain barrier, exert a brain-protective effect, and improve cerebral microcirculatory disorders. (ii) The tertiary amine group in the parent nucleus structure of the vincamine derivative is ionizable under acidic conditions, which enables efficient delivery and lysosomal escape of nucleic acid drugs through charge adsorption, thereby improving intracellular transport. (iii) The vincamine derivative inherits various pharmacological activities inherent to vincamine, and has high safety. Therefore, the vincamine derivative has good application prospects in brain-targeted delivery of drugs for treating brain diseases.
Absstract of: US20260034242A1
The present invention provides a lyophilized composition of nucleic acid-encapsulating lipid nanoparticles having a pH of 4.5 or more and 6.9 or less, including an ionic lipid represented by the formula (1):wherein symbols are as defined in the DESCRIPTION.
Absstract of: US20260034239A1
The present invention relates to compositions comprising an extracellular vesicle (EV). In particular, the extracellular vesicle (EV) comprises a single pass EV transmembrane protein fused to a moiety on the surface of the EV and/or a cargo molecule. The composition may be used to deliver the cargo molecule. Methods of manufacturing the composition are also provided.
Absstract of: US20260034202A1
The disclosure provides a sub-micron particle comprising a first payload molecule, a lipid structure and a plurality of amphiphilic polymer chains surrounding the lipid structure. The first payload molecule is a macromolecule, optionally a nucleic acid. Additionally, the hydrophobicity of the amphiphilic polymer chains changes in response to an external stimulus.
Nº publicación: US20260034223A1 05/02/2026
Applicant:
NEW YORK UNIV [US]
THE TRUSTEES OF THE STEVENS INSTITUTE OF TECH [US]
NEW YORK University,
The Trustees of the Stevens Institute of Technology
Absstract of: US20260034223A1
The present disclosure provides polymeric matrices comprising calreticulin (CRbT) and methods of producing and using such matrices. The polymeric matrices are useful in treatment of wounds (e.g., chronic diabetic wound).
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