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105
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Updated on
20/08/2025 [07:25:00]
Results 50 to 75 of 105
Absstract of: CN120137852A
The invention relates to a bifidobacterium animalis subsp. Lactis YYSJ001 with a blood sugar reducing effect and application of the bifidobacterium animalis subsp. Lactis YYSJ001. The classification name of the strain is bifidobacterium animalis subsp. Lactis, and the preservation number is CGMCC (China General Microbiological Culture Collection Center) No.33471. The invention further relates to a preparation method of the bifidobacterium animalis subsp. Lactis YYSJ001. The bacterial strain has good artificial gastric juice resistance, artificial intestinal juice resistance and intestinal tract adhesion ability, has an inhibition effect on numerous pathogenic bacteria such as escherichia coli, staphylococcus aureus, salmonella, klebsiella pneumoniae and quail chicken enterococcus, and can stimulate intestinal cells to generate glucagon-like peptide-1, so that the bacterial strain can be applied to preparation of various pathogenic bacteria. Diseases of diabetic mice can be effectively improved, and the compound can be used for preparing products for preventing and treating diabetes or assisting in reducing blood sugar.
Absstract of: CN120137051A
The invention discloses a fusion antibacterial peptide BMAP18-BSN37 and application thereof, and belongs to the technical field of gene engineering. The nucleotide sequence of the fusion antibacterial peptide BMAP18-BSN37 is as shown in SEQ ID NO. 1, and the amino acid sequence of the fusion antibacterial peptide BMAP18-BSN37 is as shown in SEQ ID NO. 2. The fusion antibacterial peptide BMAP18-BSN37 gene is inserted into a pNZ8148 expression vector to construct a recombinant expression vector pUBB, so that protein aggregation or degradation in cells can be avoided, and the survival rate of strains and the stability of protein expression are improved. The method comprises the following steps: transferring a plasmid pUBB into a lactic acid bacteria NZ9000 strain through electrotransformation, and screening a recombinant lactic acid bacteria strain capable of expressing a fusion protein BMAP18-BSN37 to obtain a recombinant strain NZ-BB; the recombinant lactic acid bacteria NZ-BB strain shows a remarkable prevention effect in an animal infection model, and can effectively reduce bacterial colonization and relieve pathological injury; the Salmonella strain has the potential of being used as an animal feed additive, can reduce the use of antibiotics and chemicals, slow down the development of bacterial drug resistance, improve animal immunity and slow down intestinal inflammation caused by salmonella, and provides support for effectively preventing the health of livestock and poult
Absstract of: CN120137870A
The invention discloses a sifA gene knockout attenuated salmonella recombinant engineering bacterium as well as a preparation method and application thereof, and belongs to the technical field of microbial biology. An intracellular vesicle (SCV) of the attenuated salmonella VNP20009 of the engineering bacterium forms a related gene sifA, and the related gene sifA is seamlessly knocked out. The engineering bacterium is named as VNP20009 delta sifA. The invention also discloses a preparation method of the engineering bacterium. The engineering bacterium has the characteristic of keeping the characteristic of specific colonization of a female parent strain VNP20009 in a tumor hypoxic region, and meanwhile, the biotoxicity of the strain is further reduced; meanwhile, the strain has a potential value of becoming a chassis strain for combined synthesis of biological tumor therapy due to relatively weak killing performance and higher intracellular load on immune cells. The invention also provides a construction method of the strain and application of the strain in treatment of mouse entity subcutaneous melanoma.
Absstract of: CN120138182A
The invention discloses a detection method for salmonella based on RPA-CRISPR/Cas12a regulation and control of fluorescence polarization enhancement. The detection method comprises the following steps: performing DNA extraction on a to-be-detected sample, and then mixing the to-be-detected sample with an RPA reagent, a dissolving agent, ddH2O, an upstream primer, a downstream primer and an activating agent to obtain an amplification product; the amplification product is mixed with Exo I enzyme, Exo I buffer and ddH2O for incubation, and a cutting product is obtained; mixing and incubating the cleavage product with water, LbaCas12a, a target sequence crRNA and an r2.1 buffer, so as to obtain a solution to be detected; and detecting the salmonella in the to-be-detected sample according to the fluorescence polarization value of the to-be-detected solution. The salmonella detection method provided by the invention has the advantages of rapidness, simplicity and convenience in operation, high sensitivity and strong specificity, and can efficiently detect salmonella.
Absstract of: CN120131712A
The invention belongs to the field of biological medicines, and provides a composition and a method for treating tumors by using attenuated salmonella and an immune checkpoint inhibitor. The anti-tumor immune response is activated in a mode of combining the attenuated salmonella and the immune checkpoint inhibitor, and the inhibition effect on tumor cells is synergistically improved. The medicine shows an excellent treatment effect on malignant tumors lacking an effective control means at present, and has a wide application prospect.
Absstract of: WO2025122955A1
Provided herein are methods and compositions for treating cancer. One composition includes an engineered bacterial cell comprising: a) a lysis gene or lysis cassette operably linked to an intracellularly induced Salmonella promoter; b) one or more of the bacterial cell genes selected from the group consisting of recA, recB, recF, sbcB, sbcCD, red, sseJ or any combination thereof are knocked out; and c) a nucleic acid sequence coding for an oncolytic virus genome.
Absstract of: WO2024155027A1
The present invention relates to an attenuated Salmonella gallinarum expressing FliC or FliC-hiL2 and use thereof. The Salmonella strain according to the present invention has excellent immune activity and exhibits excellent anti-cancer efficacy, and thus can be used as a therapeutic agent for cancer together with or independently of existing anti-cancer drugs.
Absstract of: CN120119014A
The invention belongs to the technical field of bacterial detection, and discloses a liquid-phase gene chip method for simultaneously detecting Listeria monocytogenes, Staphylococcus aureus, Salmonella and Escherichia coli, which comprises the following specific steps: step 1, designing primers; the method comprises the following steps: downloading an H ly gene sequence of listeria monocytogenes, an FemA gene of staphylococcus aureus, an i nvA gene of salmonella and an rfbE gene of escherichia coli O157: H7; after preparation work of primer design, bacterial DNA extraction and plasmid construction, simultaneous and high-throughput detection of Listeria monocytogenes, Staphylococcus aureus, Salmonella and Escherichia coli can be realized through the detection method established in the step 4, so that the detection time is effectively shortened, the operation is simpler, and the detection efficiency is improved. Meanwhile, a specificity test, a sensitivity test, a repeatability test and a clinical sample detection result show that the detection method disclosed by the invention is higher in sensitivity and lower in specificity and cost, and meets the requirements of rapid on-site real-time detection of the food-borne pathogenic bacteria.
Absstract of: CN120119010A
The invention discloses an LMTIA primer combination for detecting salmonella and application, and relates to the technical field of microbiological detection.The LMTIA primer combination comprises a first primer and a second primer, the sequence of the first primer is shown as SEQ.ID.No.1, and the sequence of the second primer is shown as SEQ.ID.No.2. The invention further discloses a kit for detecting salmonella. Amplification of the target gene of the to-be-detected sample can be completed within 30 min through the first primer, the second primer and a constant-temperature environment, expensive equipment such as a PCR instrument is not needed, the specificity is high, the false positive rate is low, the sensitivity is not worse than that of PCR, and the kit can be used for rapidly detecting salmonella on site.
Absstract of: CN120121832A
The invention relates to a double-probe detection reagent for detecting salmonella typhimurium and a preparation method of the double-probe detection reagent, and belongs to the technical field of food safety. The double-probe detection reagent is formed by respectively packaging a magnetic separation probe reagent solution and a fluorescent nano-enzyme probe reagent solution; the magnetic separation probe reagent liquid is used for specifically binding salmonella typhimurium and carrying out separation and enrichment treatment on a detection sample; the red fluorescent nano-enzyme probe reagent solution is used for specifically combining the salmonella typhimurium subjected to separation and enrichment treatment and generating a salmonella typhimurium concentration dependent colorimetric signal and a fluorescent signal. The double-probe detection reagent disclosed by the invention is short in detection time and high in detection sensitivity when being used for detecting salmonella typhimurium, and has relatively good specificity on common type strains. According to the invention, the specific surface area is high, the peroxidase-like activity is excellent, and the high-sensitivity capture efficiency is enhanced; according to the invention, mutual verification is carried out between the dual-mode signals, an internal proofreading effect is achieved, and the detection result is accurate.
Absstract of: CN120118166A
本发明通过筛选、实验验证获得一段能够代表沙门氏菌作为抗原的特异性蛋白片段，以这一段特异性蛋白片段作为抗原免疫小鼠，利用细胞融合技术得到可以稳定分泌单克隆抗体的杂交瘤细胞，最终制备了效价高、特异性好的抗沙门氏菌单克隆抗体。同样以该特异性蛋白片段免疫兔子，获得了抗沙门氏菌多克隆抗体。基于鼠单克隆抗体和兔多克隆抗体，建立沙门氏菌胶体金免疫层析检测方法，该检测方法特异性良好，为食品中沙门氏菌的检测提供了快速、简便的检测手段。
Absstract of: CN120119015A
The invention belongs to the technical field of microbiological detection, and discloses an RPA (recombinase polymerase amplification) primer pair, a real-time fluorescent RPA primer group and a kit for detecting salmonella typhimurium. The primer pair for detecting the salmonella typhimurium based on the RPA comprises an upstream primer RPA-F with a sequence as shown in SEQ ID NO: 1 and a downstream primer RPA-R with a sequence as shown in SEQ ID NO: 2, and the primer group for detecting the salmonella typhimurium based on the real-time fluorescence RPA comprises the upstream primer RPA-F, the downstream primer RPA-R and a probe RPA-P with a sequence as shown in SEQ ID NO: 3. The primer group and the primer pair can be used for rapidly detecting salmonella typhimurium, and are high in specificity and sensitivity and low in minimum detection limit.
Absstract of: CN120118856A
The invention provides a freeze-drying protective agent and a penicillin bottle freeze-drying method of salmonella bacteriophage, and belongs to the technical field of biology. The freeze-drying protective agent comprises the following components in percentage by mass: 5%-10% of trehalose, 1%-3% of mannitol, 1%-3% of lactose, 1%-3% of sodium citrate, 0.5%-2% of linseed oil, 10%-20% of skim milk powder, 1%-3% of sodium sulfate and 1%-3% of succinic acid. According to the penicillin bottle freeze-drying method of the salmonella bacteriophage, the freeze-drying recovery rate of the salmonella bacteriophage can be remarkably improved; the freeze-dried bacteriophage preparation is small in size, light in weight, easy to transport and store and capable of keeping activity for a long time at normal temperature.
Absstract of: CN120118818A
The invention provides a controllable self-destruction engineering bacterium and a preparation method thereof, attenuated salmonella typhimurium is taken as a carrier, plasmid containing PD-1 gene is introduced into the body of the bacterium, and the engineering bacterium VNP-mPD-1 is obtained; the preparation method comprises the following steps: preparing engineering bacteria VNP-mPD-1-N3, enabling the surface of the engineering bacteria to contain an azide group through a glycometabolism method to obtain the engineering bacteria VNP-mPD-1-N3 with the surface containing the azide group, and covalently linking a DBCO modified photosensitizer with the azide group on the surface of the engineering bacteria through a click chemistry method to prepare the controllable self-destruction engineering bacteria VNP-mPD-1-(at) IN. The controllable self-destruction engineering bacterium prepared by the invention is good in biological safety, can generate active oxygen under laser irradiation, and has anti-tumor performance.
Absstract of: CN120098782A
The invention relates to the technical field of microbiological detection, and particularly discloses a microfluidic device for detecting salmonella and a detection method.The microfluidic device comprises a top cover, a functional plate and a heating base which are detachably connected in sequence from top to bottom; an observation window, a first sample adding opening and a second sample adding opening are formed in the top cover; a detection bin is formed in a position, corresponding to the observation window, on the function plate; an amplification bin communicated with the second sample adding opening is formed in the functional plate; a buffer bin communicated with the first sample adding opening is formed in the functional plate; the amplification bin is communicated with the buffer bin, the buffer bin is communicated with the detection bin, and a space for placing a test strip is reserved in the detection bin; a ventilation channel is further formed in the function plate and communicates with the amplification bin. The micro-fluidic device provided by the invention is simple in structure, convenient to carry, easy to interpret a detection result and simple in operation mode, and meanwhile, in combination with the design of the micro-fluidic device, the nucleic acid detection does not need additional equipment and complicated manual intervention.
Absstract of: CN120098081A
The invention belongs to the technical field of biology, and relates to a narrow-spectrum antibacterial peptide XMK-8 and application thereof. The amino acid sequence of the narrow-spectrum antibacterial peptide XMK-8 is as shown in SEQ ID NO: 1, and the narrow-spectrum antibacterial peptide XMK-8 has no bacteriostatic activity on escherichia coli, salmonella, staphylococcus aureus and aeromonas hydrophila and only has bacteriostatic activity on pasteurella multocida and haemophilus parasuis. The antibacterial activity of the narrow-spectrum antibacterial peptide XMK-8 can still be detected after treatment with salt ions (sodium ions and potassium ions, 50-200 mmol/L), acid-base (pH 4-10) and protease K (20-100 mu g/mL) at the temperature of 0-100 DEG C, and the narrow-spectrum antibacterial peptide XMK-8 has low hemolytic activity on red blood cells of mice. The antibacterial peptide XMK-8 disclosed by the invention is expected to become a novel antibiotic substitute and has a good application prospect in prevention, treatment, diagnosis and identification of pasteurella multocida, haemophilus parasuis and infection thereof.
Absstract of: CN120093643A
The invention discloses multi-effect talcum powder for animals as well as a preparation method and application of the multi-effect talcum powder. The multi-effect talcum powder comprises the following components in percentage by mass: 1-3% of sodium benzoate, 1-3% of glycerol monolaurate, 0.5-1.5% of tea polyphenol, 7-13% of citric acid, 15-25% of corn fiber powder and 54.5-75.5% of diatomite. The talcum powder does not stick to the body, is easy to fall off, has good moisture absorption and drying effects, can improve a humid environment and adsorb odor, is good in acidic stability, has an inactivation effect on escherichia coli, salmonella, staphylococcus aureus and porcine rotavirus, and is safe, non-toxic, free of drug resistance, low in cost and stable in performance when being applied to a livestock and poultry breeding environment.
Absstract of: CN120102874A
The invention belongs to the field of salmonella detection, and discloses a fluorescent lateral flow chromatography detection method for detecting salmonella, which realizes sensitive detection of salmonella through combination of CsPbBr3 (at) SiO2 with excellent fluorescence performance and Fe3O4 with magnetic response capability. The problems that in the prior art, real-time on-site antibody detection is long in time consumption, labor-consuming, high in cost, unable to quantify and the like are solved. The fluorescent probe IPNs capable of specifically recognizing salmonella is obtained by coating the outside of perovskite quantum dots with silicon dioxide, and meanwhile, the surfaces of Fe3O4 nanoparticles are modified with salmonella antibodies to prepare the magnetic probe IMNs. The former provides a fluorescence signal, and the latter realizes rapid separation of bacteria, so that the detection is more sensitive, rapid and convenient, and is suitable for various scenes. Human eyes are highly sensitive to green fluorescence, preliminary qualitative detection can be realized without a fluorescence detector, the method is suitable for field detection, and the method is excellent in specificity, anti-interference capability and repeatability and has potential in actual detection.
Absstract of: CN120098102A
The invention relates to the technical field of biology, in particular to an antibacterial peptide Clavanin A-1, a coding gene and application of the antibacterial peptide Clavanin A-1. The invention provides an antibacterial peptide Clavanin A-1 which has good thermal stability, acid-base stability and endogenous protease degradation resistance, can obviously inhibit the growth of escherichia coli, salmonella and staphylococcus aureus, and has good application prospects in the fields of food, hygienic products, cosmetics, biopesticide, biological feed additives or natural food preservatives and the like. Wide application prospects are realized.
Absstract of: US2025177508A1
Described is a method for the generation of a live vaccine containing stable bacteria carrying at least three attenuating mutations and a vaccine containing bacteria obtained by said method.
Absstract of: US2025177534A1
This invention describes method for inactivation of microorganisms in thermostable dry formulations at ambient temperatures (AT) using UV light irradiation. According to this method microorganisms are inactivated at ambient temperatures (AT) in dry formulations where the amount of free radicals formed is relatively small and damage of nucleic acids is the main cause for the microorganism's death. The method will allow production of thermostable inactivated vaccines from wild type and live attenuated microorganisms, thermostable inactivated microbiome products, and thermostable sterilized none-live blood components, therapeutic proteins, antibodies and other fragile biopharmaceuticals.
Absstract of: AU2023312737A1
Provided herein are vaccine composition comprising a
Absstract of: CN120081916A
本发明公开了一种鼠伤寒沙门菌特异性抗原片段及其在检测鼠伤寒沙门菌抗体中的应用。所述鼠伤寒沙门菌特异性抗原片段的氨基酸序列如SEQ ID NO.1所示。本发明首次公开了以鼠伤寒沙门菌特异性抗原片段作为间接ELISA的包被抗原，建立了鼠伤寒沙门菌间接ELISA抗体检测方法，鼠伤寒沙门菌特异性抗原片段含有鼠伤寒沙门菌FliC蛋白的优势B细胞表位，能够特异性识别诱导产生的鼠伤寒沙门菌FliC蛋白抗体，在提高抗原抗体特异性结合方面有显著性的增效作用。本发明能够用于鼠伤寒沙门菌抗体的检测，为鼠伤寒沙门菌的流行病学调查以及沙门菌的防控提供了有力的技术支持。
Absstract of: CN120082663A
The invention relates to the technical field of microbiological detection, and particularly discloses a primer probe combination for detecting six food-borne pathogens and application of the primer probe combination. The detection primer probe combination for the six food-borne pathogens comprises six pairs of specific primer pairs and six probes, the nucleotide sequences of the specific primer pairs are respectively shown as SEQ ID NO.1, SEQ ID NO.4, SEQ ID NO.8, SEQ ID NO.1, SEQ ID NO.13, SEQ ID NO.16, SEQ ID NO.19, SEQ ID NO.22, SEQ ID NO.26, SEQ ID NO.29, SEQ ID NO.32 and SEQ ID NO.35, and the nucleotide sequences of the probes are respectively shown as SEQ ID NO.37-SEQ ID NO.42; the six food-borne pathogens comprise listeria monocytogenes, salmonella, vibrio parahaemolyticus, norovirus, escherichia coli O157: H7 and staphylococcus aureus. According to the present invention, the pathogens of six common food-borne diseases can be detected, the detection method has characteristics of high specificity and high sensitivity, and the pathogens do not interfere with each other and do not inhibit each other during the detection so as to achieve good stability.
Nº publicación: CN120082456A 03/06/2025
Applicant:
HEILONGJIANG HONGSHENG AGRICULTURAL TECH DEVELOPMENT CO LTD
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Absstract of: CN120082456A
The invention provides bacillus coagulans and application thereof, relates to the technical field of microorganisms, and aims to solve the problem that a biological material with a strong antibacterial function and good tolerance is lacked in the prior art. The invention provides bacillus coagulans XH-2, the preservation number of the bacillus coagulans XH-2 is CCTCC NO: M 2023759, the bacillus coagulans XH-2 is preserved in the China Center for Type Culture Collection on May 15, 2023, and the preservation address is Wuhan University, China. The bacillus coagulans XH-2 disclosed by the invention has a relatively strong inhibition effect on escherichia coli, and also has a relatively good inhibition effect on salmonella gallinarum, salmonella suis and salmonella typhimurium at the same time. According to the invention, the bacillus coagulans XH-2 is used as an active ingredient to prepare the livestock or poultry feed additive, and the strain has strong gastric juice and cholate tolerance, and can inhibit the growth of pathogenic bacteria and improve the conversion and utilization of animal feed.
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