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80
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Results 25 to 50 of 80
Absstract of: CN120860179A
The invention belongs to the technical field of medicines, and particularly relates to application of pinosine and polymyxin in preparation of antibacterial drugs, and the antibacterial drugs aim at one or more of escherichia coli, salmonella and klebsiella pneumoniae. The antibacterial agent aims at bacteria which are resistant to polymyxin. The bacteria directed by the antibacterial agent are multi-drug-resistant gram-negative bacteria. A checkerboard method minimum inhibitory concentration test and an in-vitro time sterilization curve prove that the pinosine effectively recovers the sensitivity of bacteria to the polymyxin, and meanwhile, a staining experiment and fluorescent quantitative PCR prove that the pinosine can effectively recover the sensitivity of the bacteria to the polymyxin by destroying the completeness of a bacterial cell membrane and inhibiting the transcription expression of a polymyxin drug-resistant gene mcr-1. The antibacterial activity of the polymyxin on bacteria is effectively enhanced. The invention provides a novel application of densipine in enhancing the antibacterial activity of polymyxin antibiotics, and can solve the technical problems of low clinical drug resistance, low therapeutic index and the like of polymyxin.
Absstract of: CN120866303A
The invention provides a probe, a kit and a detection method for detecting salmonella, and belongs to the technical field of pathogenic bacterium detection. The research provides an unmarked fluorescent biosensing platform for high-sensitivity detection of salmonella. A target sequence is introduced into a catalytic core sequence of Aurora DNAzyme, so that a signal probe E-Aurora is constructed. The E-Aurora can be combined with a substrate 4-methylumbelliferone phosphate disodium salt to generate a strong fluorescent compound 4-MU. When salmonella exists, PfAgo is activated and specifically cuts the E-Aurora probe, so that the structural integrity of E-Aurora is destroyed and the catalytic ability of E-Aurora is lost, and the generation of a fluorescence signal is hindered. The biosensor realizes ultra-high sensitivity detection of salmonella, the limit of detection (LOD) is as low as 1 CFU/mL, and an ideal recovery rate (80-120%) is obtained in actual sample detection. The detection method disclosed by the invention is simple to operate and wide in application range, and can be used for determining trace salmonella in food.
Absstract of: CN120870552A
The invention discloses a salmonella typhimurium aptamer lateral flow chromatography test strip based on the photothermal effect of a ferroferric oxide and colloidal gold composite nanomaterial, a preparation method and application, and belongs to the technical field of lateral flow chromatography test strips. The preparation of the probe comprises the step of preparing a Fe3O4 (at) Au composite nano material; the preparation method comprises the following steps: under the protection of nitrogen, dissolving FeCl3. 6H2O and FeCl2. 4H2O in deionized water, adding ammonia water, stirring at room temperature, adding trisodium citrate, collecting by using a magnet, then adding into a boiling HAuCl4 solution, keeping boiling until the color of the solution becomes reddish brown, continuing heating, cooling, and collecting by using a magnet; the test strip provided by the invention can realize quantitative detection of salmonella typhimurium.
Absstract of: AU2024264505A1
Provided are non-naturally occurring systems, methods, and compositions for the detection of microbes. The disclosure relates to the detection of an antigen specific to a microbe, such as a foodborne, an environment-borne, and a bloodborne bacteria, using capture antibody and moiety, detector antibody and moiety, and a light-emitting particle.
Absstract of: WO2025224268A1
The present invention relates to a live attenuated Gram-negative bacterium modified to enable enhanced vacuole escape. In particular, the invention relates to a live attenuated Gram-negative bacterium comprising a heterologous polynucleotide encoding a prokaryotic disulfide bond isomerase, or functional fragment thereof, wherein said heterologous polynucleotide encoding the prokaryotic disulfide bond isomerase is operably linked to a promoter, or a live attenuated Gram-negative bacterium comprising an endogenous prokaryotic disulfide bond isomerase, or functional fragment thereof, wherein the endogenous prokaryotic disulfide bond isomerase is upregulated compared to its basal level expression.
Absstract of: WO2025224621A1
Time sensitive biopharmaceutical processing updates can be implemented using lateral flow devices to test on-site during manufacturing. Lateral flow testing for an analyte such as, for example, impurities (e.g., host cell proteins), during manufacturing of a biopharmaceutical drug product is completed within twenty-five minutes of collecting a sample from the manufacturing line. That is, all sample preparation, such as adding reagent or diluting the sample, contacting the prepared sample to a lateral flow device, and detecting presence or absence of the analyte is completed within twenty-five minutes (e.g., 20 minutes, 18 minutes, 15 minutes) from collection such that processing adjustments during manufacturing can be implemented.
Absstract of: US2025334572A1
Time sensitive biopharmaceutical processing updates can be implemented using lateral flow devices to test on-site during manufacturing. Lateral flow testing for an analyte such as, for example, impurities (e.g., host cell proteins), during manufacturing of a biopharmaceutical drug product is completed within twenty-five minutes of collecting a sample from the manufacturing line. That is, all sample preparation, such as adding reagent or diluting the sample, contacting the prepared sample to a lateral flow device, and detecting presence or absence of the analyte is completed within twenty-five minutes (e.g., 20 minutes, 18 minutes, 15 minutes) from collection such that processing adjustments during manufacturing can be implemented.
Absstract of: KR20250155130A
본 발명은 서울특별시 서울기술연구원 2022년도 캠퍼스타운 기술매칭 지원사업(반려동물 장내미생물 자가검사키트)을 통해 개발된 기술이다. 본 발명은 동물의 장내미생물 검출용 조성물 또는 키트에 관한 것으로서, 본 발명의 조성물 또는 키트는 미생물 유래 독소에 특이적으로 결합할 수 있는 물질을 프로브로 포함함으로써, 시중에 널리 사용되는 코로나 자가검진 키트와 마찬가지로 소비자 스스로 반려동물의 장내미생물을 검사할 수 있도록 하고, 이에 따라 반려동물의 장내미생물 분석에 대한 소비자 접근성을 크게 향상시킬 수 있다.
Absstract of: WO2025225874A1
The present invention relates to a method for detecting live foodborne pathogens using novel bacteriophages LEC1, LBC9, and LSE2. By using this method, Escherichia coli, Bacillus cereus, and Salmonella spp., which are live foodborne pathogens in food, can be rapidly and accurately detected at the same time, and thus the method can be effectively used for preventing food poisoning.
Absstract of: WO2025224251A1
The present invention relates to a live attenuated Gram-negative bacterium comprising a modified hlyCABD operon, wherein the modified hlyCABD operon is split into a first segment and a second segment, the first segment being operably linked to a first independently controlled promoter, wherein the first independently controlled promoter is a strong constitutive promoter or a strong vacuole-induced promoter, and the second segment being operably linked to a second independently controlled promoter, wherein the second independently controlled promoter is a strong vacuole-induced promoter, and wherein the first segment comprises a heterologous polynucleotide encoding a lysin upstream of a hlyAs translocation sequence, wherein the heterologous polynucleotide encoding one or more cargo molecules replaces a hlyA gene, and wherein the second segment comprises hly genes involved in secretion.
Absstract of: KR20240012662A
The present invention relates to a genetic construct characterized in that the anti-sigma factor flgM gene and the gene encoding strep-tag are linked to encode a fusion protein of flgM and strep-tag so that a strep-tag may be expressed on the surface of an anticancer strain that may be targeted to a tumor site and stimulate immune activity, and an anticancer adjuvant and a tumor imaging aid which is transformed thereby and exhibits anticancer activity itself and may be usefully used for the diagnosis and treatment of tumor cells together with an anticancer substance or contrast agent labeled with a substance which specifically reacts with the strep-tag.
Absstract of: WO2024137831A2
A composition of bacteriophages comprising at least one phage selected from TTS1, TTS2, TTS3, TTS4, TTS5, and TTS6, wherein the phages are optionally encapsulated; and a method for preventing or treating an infection caused by Salmonella Gallinarum by administering to a subject a therapeutically effective amount of the composition.
Absstract of: EP4641200A2
Disclosed herein are methods and systems for rapid detection of microorganisms such as Listeria spp. in a sample. A genetically modified bacteriophage is also disclosed which comprises an indicator gene in the late gene region. The specificity of the bacteriophage, such as Listeria-specific bacteriophage, allows detection of a specific microorganism, such as Listeria spp. and an indicator signal may be amplified to optimize assay sensitivity.
Absstract of: CN120842432A
本发明涉及一种应对多种致病性肠杆菌感染防治的融合蛋白、免疫原性组合物、重组简并疫苗，以及分子架构设计和应用等。本发明筛选到3种细胞免疫抗原Tuf、DnaK、fusA，构建的3种抗原的融合蛋白分子可显著抑制多种肠杆菌感染引起的组织病变，具有良好的免疫原性，起到有效防治和免疫保护作用，广谱且高效地预防多种致病性肠杆菌感染，具有广阔的工业应用前景。
Absstract of: CN120850205A
The invention relates to the technical field of food safety, and discloses a food microbial contamination rapid detection method fusing a knowledge graph and deep learning, and the method comprises a data collection module, a knowledge graph engine, a deep learning calculation unit, a dynamic optimization module, a visual interaction terminal and a traceability management platform. A micro-fluidic chip and impedance sensing combined technology is adopted, the traditional long-time detection period is shortened, the real-time monitoring requirement of cold-chain logistics is met, a spectrum-bioelectricity-microscopic image three-mode space-time alignment model is created for the first time, dimension gaps are eliminated through feature space mapping, the recognition accuracy of complex matrix pollution is improved, and the real-time monitoring requirement of the cold-chain logistics is met. By constructing a rule engine driven by an industry knowledge graph, dynamic model updating is achieved through an incremental learning module, the detection rate of novel salmonella variants is increased, and the problem of the omission ratio of new pathogens is solved.
Absstract of: CN120843440A
The invention discloses application of a method for enhancing the treatment effect of salmonella bacteriophage, and relates to the technical field of microorganisms. According to the method, bacteriophage is added into salmonella for in-vitro culture, after continuous subculture, the salmonella is dropwise added to an SS plate containing the bacteriophage, and resistant bacteria of the bacteriophage are screened. The split bacteriophage is screened aiming at the resistant bacteria of the bacteriophage, and the split bacteriophage and the initial bacteriophage form a bacteriophage cocktail formula, so that the salmonellosis can be well prevented and treated, and the generation of the resistant bacteria is delayed. The method has the beneficial effects that compared with the existing method for screening the bacteriophage-resistant bacteria through a double-layer plate method, the method is more convenient, the operation is simple, and the screening efficiency of the bacteriophage-resistant bacteria is greatly improved. The bacteriophage cocktail contains the bacteriophage for cracking the resistant bacteria, so that the treatment effect of the bacteriophage is improved, and the practical application scene is quite high.
Absstract of: CN120843394A
The invention discloses a DC (dendritic cell) capture type engineering bacterial vaccine for realizing cytoplasm antigen transfer by utilizing gap connection, which is characterized in that attenuated salmonella VNP20009 is utilized to simultaneously express Antigen 4T1-M8 and DC capture peptide CBP-12 to increase contact so as to enhance formation of gap connection between tumor cells and DC and promote delivery of antigen to DC cytoplasm, so that MHC-I mediated cross presentation is enhanced. In addition, as an intracellular bacterium, the VNP20009 can infect tumor cells and colonize in the tumor cells. Therefore, the tumor antigen carried by the VNP20009 can be expressed in cells, so that the tumor antigen can be presented to the surfaces of tumor cells by MHC-I as an endogenous antigen to be recognized by specific CD8 + T cells.
Absstract of: CN120843705A
The invention discloses a salmonella enterica ultra-rapid detection kit based on a whole-process nucleic acid detection chip and a detection method thereof. The kit comprises a rapid hot start DNA polymerase, a PCR reaction mixed solution, a positive reference substance and a negative reference substance, the kit also comprises the following primers which take the salmonella enterica V3-V4 region as a target sequence and are designed by a PCR fluorescent probe method based on a whole-process nucleic acid detection chip technical platform: an upstream primer F, a downstream primer R and a detection probe P, and the nucleotide sequences of the three primers are shown as SEQ ID NO. 1-3. According to the detection kit disclosed by the invention, a V3-V4 target sequence can be rapidly detected on the micro-fluidic chip within more than ten minutes, so that the accuracy and the specificity of detecting the salmonella enterica gene are ensured; the invention provides the salmonella enterica gene detection kit which is more comprehensive in detection effect, high in specificity, good in sensitivity, low in omission ratio, convenient, simple and easy to operate.
Absstract of: CN120829857A
The invention discloses a novel salmonella pullorum SP1910 strain, a pullorum disease antigen prepared from the novel salmonella pullorum SP1910 strain and a preparation method and application of the antigen, the strain has better stability and specificity, the detection effect of the antigen prepared from the strain on pullorum disease is superior to that of a commercial antigen, the pullorum disease can be efficiently detected, positive chickens are eliminated, and the detection cost is reduced. Chicken flocks are purified, infection of pullorum disease is reduced, and breeding benefits are improved.
Absstract of: KR20250151120A
본 발명은 살모넬라(Salmonella) 검출을 위한 재조합효소-중합효소 증폭법(recombinase polymerase amplification)용 프라이머 세트 및 이를 이용한 핵산 측면 흐름 면역 분석(nucleic acid lateral flow immunoassay)용 살모넬라(Salmonella) 검출용 키트에 관한 것으로, 본 발명의 프라이머 세트는 살모넬라(Salmonella)속에 특이적인 유전자인 invA 유전자를 가장 높은 효율로 증폭하여 살모넬라(Salmonella) 검출이 우수할 뿐만 아니라, 재조합효소-중합효소 증폭(recombinase polymerase amplification) 수행시 비교적 낮은 온도에서 짧은 시간안에 증폭이 용의할 뿐만 아니라 상기 프라이머 세트의 역방향 프라이머 말단에 제1 표지물질이 결합하여 검출 가능한 발색입자인 금나노입자가 결합되고, 상기 프라이머 세트가 증폭하는 서열의 일부 서열에 특이적으로 결합하는 부위를 포함하는 프로브는 5' 말단에 제2 표지물질이 결합하여 핵산 측면 흐름 면역 분석(nucleic acid lateral flow immunoassay)에 적용시 RPA 증폭산물을 쉽게 검출 할 수 있는 살모넬라(Salmonella) 검출용 프라이머 세트 및 이의 용도를 제공한다.
Absstract of: WO2024192346A1
Technologies for providing immunogenic compositions (e.g., vaccines) and methods of inducing immune responses in subjects in need thereof.
Absstract of: CN120818041A
The invention relates to the field of biological medicine, in particular to an alloautophagy receptor NDP52 protein 202-site lysine acetylation antibody and a preparation method and application, the alloautophagy receptor NDP52 protein 202-site lysine acetylation antibody is based on NDP52 protein 202-site lysine acetylation polypeptide, and the invention provides the NDP52 protein 202-site lysine acetylation antibody and the preparation method and application. The preparation method of the antibody comprises the following steps: coupling the NDP52 protein 202-site lysine acetylated polypeptide with KLH and/or BSA to obtain an antigen, emulsifying the antigen, immunizing a rabbit to obtain immunized rabbit serum, and determining the antibody titer of the antibody in the immunized rabbit serum, and finally, purifying the antibody to obtain the protein 202 lysine acetylation antibody of the allogenic autophagy receptor protein NDP52. The prepared antibody can be applied to a salmonella bacterial infection detection reagent, and the detection accuracy is improved.
Absstract of: CN120789145A
The invention discloses a preparation for treating chicken salmonellosis. The preparation is prepared from the following raw materials in parts by weight: main materials: coptis chinensis extract, sanguisorba officinalis extract, Chinese knotweed herb extract, myrobalan, pomegranate rind and allicin; coating materials: cereal prolamin, a slow-release agent and a reinforcing agent; the auxiliary materials comprise an adhesive, an antioxidant and a phagostimulant. The preparation method comprises the following steps: S1, pretreating; S2, mixing; S3, granulating; S4, coating; the traditional Chinese medicine composition can effectively treat pullorum disease caused by chicken salmonellosis, is good in treatment effect, and improves breeding benefits; through a coating material, an acid-resistant layer with high mechanical strength and a sustained-release layer are formed, effective components are prevented from being decomposed and inactivated in advance, the components are prevented from being mechanically damaged, meanwhile, sustained release can be achieved, the effective components are prevented from being rapidly discharged, and therefore the treatment effect is further improved.
Absstract of: CN120796203A
The invention discloses a drug-resistant Escherichia coli bacteriophage with efficient cross-species lysis capability and application of the drug-resistant Escherichia coli bacteriophage, the drug-resistant Escherichia coli bacteriophage is named as Escherichia coli bacteriophage PE-48, and the preservation number of the drug-resistant Escherichia coli bacteriophage is CCTCC (China Center for Type Culture Collection) NO: M 2025261. The strain not only can efficiently split pathogenic escherichia coli, but also can split salmonella, has efficient cross-species splitting capacity, and can effectively prevent and treat various symptoms caused by escherichia coli and relieve phenomena such as large-scale death and the like. The bacteriophage is separated from the natural environment, is a natural biological purification factor, and has the advantages of being green, environmentally friendly, safe, free of residues, efficient in bacteriostasis and the like. Escherichia coli and salmonella infection can be effectively prevented and treated in the chick breeding process.
Nº publicación: CN120796521A 17/10/2025
Applicant:
CHENGDU UNIV
\u6210\u90FD\u5927\u5B66
Absstract of: CN120796521A
The invention belongs to the technical field of microbiological detection, and discloses a composite probe for detecting salmonella enteritidis and a preparation method. The composite probe for detecting the salmonella enteritidis comprises magnetic nanoparticles FeO, wherein the surface of the magnetic nanoparticles FeO is modified with an aptamer apt which is specifically combined with the salmonella enteritidis; the surface of the long afterglow nano particle PLNPs is modified with a DNA (Deoxyribose Nucleic Acid) sequence cDNA (Complementary Deoxyribonucleic Acid) complementary with the aptamer; the aptamer apt and the complementary DNA sequence cDNA are subjected to hybridization to form a composite probe structure FeO-SEapt (at) PLNPs-cDNA (complementary deoxyribonucleic acid). The long afterglow luminescence characteristic of PLNPs (ZnGaO: Cr) is utilized, and an excitation light source is stopped before detection, so that signal acquisition completely avoids autofluorescence of a sample matrix, background fluorescence interference is thoroughly eliminated, and the signal-to-noise ratio is remarkably improved.
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