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95
results.
Updated on
05/07/2025 [07:45:00]
Results 25 to 50 of 95
Absstract of: US2025169515A1
A continuous feed, shell egg pasteurization system and method uses sprayed heated water. The unpasteurized shell eggs are conveyed and rotated through a horizontal tunnel. An overlapping pattern of heated water is sprayed downward onto the rotating shells eggs. Verified testing shows that the shell eggs achieve a statistical 5 log reduction of Salmonella enteritidis that may have been present in the yolk in the respective unpasteurized shell egg, while at the same time are not overcooked and have little to no whitening of the albumen.
Absstract of: US2023406892A1
The present invention relates to bacteriocins for control of Salmonella enterica (salmocins). The bacteriocins are derived from Salmonella. The salmocins can be expressed in plants and can be used in a method of preventing or reducing infection or contamination of an object with Salmonella.
Absstract of: AU2023361317A1
The present invention relates to a modified live attenuated Gram-negative bacteria, wherein said bacteria has been modified in such a way that RNA molecules can be safely and efficiently delivered to target eukaryotic cells. As such, the present invention relates a to a bacterial delivery system and various uses and methods thereof.
Absstract of: KR20250073901A
본 발명은 혈액 기반 인체 마이크로바이오타 조성 검사 방법 및 이의 용도에 관한 것으로, 보다 구체적으로는 환자 유래 단리된 생물학적 시료를 384종의 인체 장내미생물 항원으로 이루어진 마이크로어레이에 처리하는 단계를 포함하는 질환 관련 치료제 후보 장내미생물의 스크리닝 방법 및 상기 스크리닝 방법을 통해 선발된 질환 관련 치료제 후보 장내미생물에 관한 것이다.
Absstract of: US2025164483A1
Herein are presented methods for incorporating a novel bacteriophage, CAM-21, that exhibits lytic activity against pathogenic E. coli, into food, food packaging, films, and quantum dot-based biosensors. The bacteriophage contains no genes associated with toxins, virulence factors, antibiotic resistance, lysogeny, or allergens. Methods are provided for encapsulating the bacteriophage with proteins and/or carbohydrate materials to enhance stability. Various films in which the bacteriophage are incorporated, and which similarly exhibit suppression of pathogenic E. coli, are also provided. Additionally, when conjugated with N-doped graphene quantum dots, CAM-21 enables biosensor development for E. coli detection in food products through altered photoluminescence emission spectra, and methods for making and using such biosensors are provided.
Absstract of: AU2024256082A1
The present invention relates to the technical field of probiotics, in particular to a Lactiplantibacillus plantarum GOLDGUT-LP618 having a function of resisting Salmonella infection and application thereof. The Lactiplantibacillus plantarum GOLDGUT-LP618 provided by the present invention is preserved in China General Microbiological Culture Collection Center, with the preservation number of CGMCC No. 28399. The strain has high resistance to acid and bile salt and can adapt to the digestive tract environment. The strain can inhibit Salmonella infection, relieve diarrhea, inflammation and intestinal damage caused by Salmonella infection, and promote intestinal health. The strain can be used for preparing functional foods, dietary supplements or drugs that can resist Salmonella infection and improve diarrhea and inflammation caused by Salmonella infection, and has good application prospects.
Absstract of: WO2025102801A1
Provided are a method for preparing freezing shock-treated monocytes or macrophages loaded with attenuated Salmonella and the use thereof. The method comprises: loading engineering-modified attenuated Salmonella in monocytes or macrophages, and performed a freezing shock treatment on the monocytes or macrophages loaded with the strain by means of liquid nitrogen. The method for preparing the freezing shock-treated immune cells loaded with the strain is simple and easy to operate. The source problem of the monocytes or macrophages loaded with the engineering-modified attenuated Salmonella is solved, and the method has good application prospects. According to the strategy, by means of avoiding exposure and heterologous stimulation of bacteria, the biological safety of bacteria-based anti-tumor treatment is improved; and the anti-tumor immune response is promoted by means of the high titer of an intratumoral strain, so that a stronger anti-tumor efficacy is obtained.
Absstract of: US2025161423A1
The present invention relates to self-assembling protein nanoparticles encapsulating immunostimulatory nucleid acids. Furthermore, the invention relates to the use of such nanoparticles for vaccination.
Absstract of: KR20250069736A
폴리디아세틸렌 기반 색 변이 리포좀 입자를 이용한 살모넬라균의 신속한 검출방법을 개시한다. 상기 살모넬라균의 신속 검출방법은 (1) 살모넬라균을 박테리아 단백질 추출 시약에 용해시켜 살모넬라균 조각으로 추출하여 살모넬라균을 전처리하는 단계; (2) 전처리된 살모넬라균과 리포좀 입자를 혼합하여 혼합액을 제조하는 단계; 및 (3) 상기 혼합액의 색변환을 분석하여 살모넬라균을 검출하는 단계;를 포함하고, 살모넬라균을 신속하게 검출할 수 있다.
Absstract of: AU2023382983A1
The present invention relates to a DNA construct including: a gene encoding a flagellin protein; and a gene encoding an immunoenhancer (adjuvant) protein. For effective cancer therapy by selectively killing only cancer cells, an attenuated Salmonella strain according to the present disclosure is designed to produce immunogenic substances in cancer tissue to induce a strong anti-cancer immune response, whereby tumor sizes in metastatic cancers as well as primary cancers can be significantly inhibited. Thus, the strain can be advantageously used in a prophylactic or therapeutic composition for improving survival rates.
Absstract of: WO2025100987A1
Cyclic dinucleotides, which are a type of signaling substance for cancer treatment, are secondary messengers of intracellular events initiated by GPCR activation and act as a stimulator of interferon genes (STING), and thus can have a significant effect on tumor suppression. Meanwhile, when cancer occurs in a subject, angiogenesis and cell growth proceed at a very high rate in the body, and thus an oxygen-deficient environment is created due to incomplete angiogenesis in cancer tissues, which may be very suitable for the proliferation of anaerobic bacteria such as Salmonella sp. strains or E. coli. Therefore, the present invention relates to a DNA construct into which is introduced a gene for an enzyme that synthesizes a signaling substance for cancer treatment, e.g., a cyclic dinucleotide, or to a strain transformed with a vector comprising the DNA construct. The DNA construct or the strain transformed with a vector comprising the DNA construct, according to the present invention, targets cancer in a subject and then secretes C-di-AMP or C-di-GMP synthase in the surrounding environment of the cancer, and thus can very effectively prevent or treat cancer and, at the same time, can diagnose cancer in real time.
Absstract of: AU2023312737A1
Provided herein are vaccine composition comprising a
Absstract of: WO2025092264A1
Provided in the present invention are Streptococcus salivarius subsp.thermophilus VB331 and the use thereof. The strain is deposited at the China General Microbiological Culture Collection Center, with the deposit number of CGMCC NO.28407. The Streptococcus salivarius subsp.thermophilus can effectively inhibit the colonization, propagation and growth of various digestive tract pathogenic bacteria, including Escherichia coli, Staphylococcus aureus, Salmonella, Enterococcus faecalis, Listeria monocytogenes and Shigella, and especially has a strong inhibitory effect on Clostridium perfringens. The strain is a natural strain, is very safe, and can provide a new source of probiotics for the development of antibacterial, bacteriostatic and other functional products against multiple harmful bacterial infections.
Absstract of: US2025147011A1
Disclosed is a covalently-linked multilayered three-dimensional matrix comprising capture molecules, linkers and spacers (referred to as a Molecular Net) for specific and sensitive analyte capture from a sample. Also disclosed herein is a Molecular Net comprising covalently-linked multilayered three-dimensional matrix comprising more than one type of capture molecule and more than one type of linker and may comprise one or more spacer for specific and sensitive capture of more than one type of analyte from a sample. A Molecular Net may comprise a pseudorandom nature. Use of various capture molecules, linkers and spacers in a Molecular Net may confer unique binding properties to a Molecular Net. Porosity, binding affinity, size exclusion abilities, filtration abilities, concentration abilities and signal amplification abilities of a Molecular Net may be varied and depend on the nature of components used in its fabrication. Uses of a Molecular Net may include analyte capture, analyte enrichment, analyte purification, analyte detection, analyte measurement and analyte delivery. Molecular Nets may be used in liquid phase or on solid phases such as nanomaterials, modified metal surfaces, nanospheres, microspheres, microtiter plates, slides, pipettes, cassettes, cartridges, discs, probes, lateral flow devices, microfluidics devices, microfluidics devices, optical fibers and others.
Absstract of: CN119932072A
本发明公开了一种减毒鼠伤寒沙门氏菌EN‑VNP菌株及其制备方法和应用，减毒鼠伤寒沙门氏菌EN‑VNP菌株的制备方法，包括如下步骤：在沙门氏菌VNP20009菌株基础上依次敲除或沉默鞭毛蛋白基因fliC、fljB、磷酸乙醇胺转移酶基因eptA、4‑氨基‑4‑脱氧‑L‑阿拉伯糖转移酶基因arnT、磷酸转移酶yeiU以及敲入或过表达磷酸转移酶基因lpxE之后形成的菌株，制得减毒鼠伤寒沙门氏菌EN‑VNP菌株。本发明的具有低毒和T细胞佐剂效果的减毒鼠伤寒沙门氏菌EN‑VNP及其制备的EN‑OMV抗原递送系统，使改善后的菌株不含有鞭毛蛋白且LPS分子结构发生改变，具有低毒和T细胞佐剂效果，且能够正常扩增培养。
Absstract of: CN119923470A
The present invention relates to a modified live attenuated Salmonella strain comprising at least one chromosomal integrated synthetic polynucleotide sequence inserted in a predetermined pseudogenomic position, said sequence comprising at least one defined recombination site for introducing a heterologous polynucleotide sequence encoding a polypeptide, wherein the chromosome integration synthetic polynucleotide sequence is located within at least one genomic site, the genomic site being defined by any one of SEQ ID NO: 1-30 or a sequence having at least 70% identity with any one of SEQ ID NO: 1-30. The invention also relates to vaccine compositions comprising the modified strains and various uses and methods thereof.
Absstract of: CN119913268A
The invention discloses a multiple qPCR (quantitative polymerase chain reaction) detection reagent for detecting neonatal gastrointestinal infection pathogens. The kit comprises specific primers and probes for detecting enterohemorrhagic escherichia coli, staphylococcus aureus, pseudomonas aeruginosa, streptococcus agalactiae, klebsiella pneumoniae, staphylococcus epidermidis, beta hemolytic streptococcus, salmonella, rotavirus and adenovirus. According to the invention, different fluorescently-labeled probes are utilized to add specific primers and probes of multiple pathogens into a reaction system to detect multiple targets at the same time, and the method has the advantages of good specificity, high sensitivity, short detection period, capability of simultaneously detecting multiple pathogens, rapidness, simplicity, convenience and economy; a convenient method is provided for rapid detection of pathogens causing neonatal gastrointestinal infection, and the kit has important significance in epidemiological research, clinical early molecular diagnosis and the like.
Absstract of: CN119913066A
The invention provides a Lactobacillus paracasei, which has a preservation number of CGMCC (China General Microbiological Culture Collection Center) No.32951. The Lactobacillus paracasei has a preservation number of CGMCC No.32951. The Lactobacillus paracasei has a preservation number of CGMCC No.32951. The lactobacillus paracasei ID001 provided by the invention has an inhibition effect on enteropathogenic bacteria such as salmonella, escherichia coli, staphylococcus aureus and the like. The probiotic preparation is obtained through fermentation and the dendrobium officinale extract, and the probiotic preparation has the immunoregulation effect through performance verification and screening.
Absstract of: CN119913098A
The invention discloses a mesenchymal stem cell loaded with attenuated salmonella, which is prepared by the following steps: loading attenuated salmonella VNP by using a mesenchymal stem cell (MSC) to obtain an MSC-VNP cell; the attenuated salmonella is attenuated salmonella typhimurium VNP20009 and a derivative or gene modified strain thereof, and the strain is an expression plasmid which does not carry or carries an expression therapeutic gene and a tracer protein exogenous gene; the therapeutic gene is a coding gene of a protein which can be expressed in attenuated salmonella and has a therapeutic effect, and comprises a cell apoptosis anti-tumor gene, an angiogenesis inhibitor gene or an immune checkpoint blocker antibody gene, and the foreign gene of the tracer protein is Dsred; the expression plasmid is provided with a promoter lac which is commonly used in attenuated salmonella; and the plasmid contains an anti-plasmid loss element AT. The mesenchymal stem cell can effectively load the attenuated salmonella, can also effectively release the attenuated salmonella, and can be used as a universal cell therapy carrier, so that the therapy cost is saved.
Absstract of: CN119913069A
The invention discloses lactobacillus craw PN5 and application thereof, and belongs to the field of microorganisms. The Lactobacillus craw PN5 is preserved in the Guangdong Microbial Culture Collection Center, and the preservation number is GDMCC NO: 65605. The strain is screened from intestinal tracts of spotted-brown chickens, is good in source safety, has a good inhibition effect on pathogenic bacteria including salmonella pullorum, escherichia coli and the like, has good application potential in the aspect of preventing and treating the pathogenic bacteria, is wide in prospect, can be used for preparing products for preventing and treating the pathogenic bacteria, and has wide application prospects. The strain is a probiotic strain worthy of development.
Absstract of: CN119913111A
The invention discloses a salmonella bacteriophage and application thereof, the salmonella bacteriophage is salmonella bacteriophage TZCZ65 and is preserved in China Center for Type Culture Collection, CCTCC NO: M 20242879, the preservation date is December 23, 2024, and the preservation address is Wuhan. The salmonella bacteriophage TZCZ65 disclosed by the invention is good in stability, free of non-toxic drug-resistant genes, high in safety, wide in host range, short in incubation period and high in filial generation bacteriophage outbreak amount, has splitting activity on salmonella from different sources, can be applied to livestock and poultry slaughtering, processing and breeding links, and has broad application prospects. A safe and efficient biological antibacterial product is provided for livestock and poultry and products thereof.
Absstract of: US2025134980A1
The present disclosure relates to novel immunogenic monovalent and multivalent polysaccharide-protein conjugate vaccine compositions comprising a polysaccharide selected from Salmonella serovar strains S. typhi; S. paratyphi A; S. typhimurium and S. enteritidis and alternative improved methods of polysaccharide fermentation, polysaccharide purification, polysaccharide-protein conjugation and stable formulation. The present disclosure further relates to methods for inducing an immune response in subjects against Salmonella and non-typhi related diseases and/or for reducing or preventing Salmonella typhi and non-typhi related diseases in subjects using the compositions disclosed herein. The vaccine elicits bactericidal antibodies and is useful for prevention of gastroenteritis, enteric and typhoid fever.
Absstract of: WO2025090839A1
Described herein are compositions, methods, and kits for detecting diarrhea causing pathogens from patient, food, or environmental samples. One embodiment described herein is primer pairs and probes for multiplex polymerase chain reaction (PCR) based assays for the detection of gastrointestinal pathogens, such as Adenovirus, Astrovirus, Rotavirus, Norovirus, Sapovirus, Campylobacter species, Clostridium difficile, Enteroaggregative E. coli (EAEC), Enteropathogenic E. coli (EPEC), Enterotoxigenic E. coli (ETEC), Shiga-like toxin-producing E. coli (STEC), Shigella/Enteroinvasive E. coli (EIEC), E. coli O157, Listeria monocytogenes, Plesiomonas shigelloides, Salmonella species, Yersinia enterocolitica, Vibrio species, Cryptosporidium species, Cyclospora cayetanensis, Entamoeba histolytica, Giardia intestinalis, or Giardia lamblia. Other embodiments include methods and kits for detecting gastrointestinal pathogens.
Absstract of: EP4545628A1
The present application relates to a Limosilactobacillus fermentum MSJK0025 from breast milk for adjusting gut microbiota and an application thereof. The Limosilactobacillus fermentum MSJK0025 from breast milk is preserved in China General Microbiological Culture Collection Center, with a preservation number of CGMCC No.26426. The Limosilactobacillus fermentum from breast milk provided in the present application is a new strain separated from the healthy nursing woman, named as "Limosilactobacillus fermentum MSJK0025", having good antibiotics sensitivity, and its property can be stably inherited. It has good resistance to acid, bile salt, and artificial gastric juice and intestinal juice, and fast growth rate and good safety. At the same time, the strain has strong survival capability in the gut, and effectively inhibits pathogenic bacteria in the gut such as Escherichia coli, Staphylococcus aureus, Salmonella typhimurium, and Candida albicans, but does not inhibit the probiotic in the gut such as lactobacillus and bifidobacterium, so the strain has broad application prospect in adjusting the balance of gut microbiota.
Nº publicación: CN119899903A 29/04/2025
Applicant:
CHINA JILIANG UNIV
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Absstract of: CN119899903A
The invention discloses a cdLAMP-based detection kit for simultaneously detecting staphylococcus aureus and salmonella and a detection method thereof, and relates to the field of biological detection.The detection kit comprises a silicon-based nano porous chip, a primer probe combination, 20 mM Tris-HCl, 10 mM KCl, 8 mM MgSO4, 10 mM (NH4) 2SO4, 0.05% Tween-20, a 2.5 mu L DNA template, 1.4 mM dNTP, 0.16 U/mu L Bst DNA polymerase and DEPC; the primer probe combination comprises a primer probe and a primer probe, wherein the primer probe is designed according to a nuc gene of staphylococcus aureus: GenBank registration number EF529607.1, and the primer probe is designed according to a fimY gene of salmonella: GenBank registration number JQ665438.1; according to the invention, dual detection is realized through a chip and a two-color fluorescence channel carried by an imaging analyzer, and compared with the existing detection method, the method has higher sensitivity and accuracy.
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