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负载生长因子的双层GelMA-AlgMA功能性水凝胶支架的制备及其应用

Resumen de: CN121513272A

本发明公开了负载生长因子的双层GelMA‑AlgMA功能性水凝胶支架的制备及其应用。包括以下步骤：制备复合KGN的GelMA水凝胶前体溶液；制备复合 BMP‑2的AlgMA水凝胶前体溶液；3D打印。本发明的有益效果在于：将复合KGN的GelMA和复合 BMP‑2的AlgMA结合为双层支架，KGN促进软骨形成，BMP‑2促进骨形成，生长因子针对性地释放，针对骨软骨界面的不同组织层进行特异性修复。

一种肩关节抗生素间隔器的制备方法

Resumen de: CN121515462A

本发明涉及医学辅助工具的制备方法，尤其涉及一种肩关节抗生素间隔器的制备方法。它包括以下步骤，A、将健侧的CT扫描数据输入3D软件得健侧的肱骨全长3D模型，健侧模通过镜像制作“患侧”正常肱骨全长3D模型得纠正模；B、通过纠正模数据确认肩关节抗生素间隔器模型：C、制作肩关节抗生素间隔器模具并通过3D打印机打印出肩关节抗生素间隔器模具；D、在肩关节抗生素间隔器模具的上模腔和下模腔中填充满骨水泥后合膜直至骨水泥完全固化，得肩关节抗生素间隔器。本发明所得肩关节抗生素间隔器更加美观和精准，从而更好维持软组织张力、适应上臂长度，它与感染切除后缺损骨结构匹配和接触，为间隔期肱骨截骨后需修复结构提供更好稳定性。

一种硬组织修复材料及其制备方法

Resumen de: CN121513265A

本发明公开了一种硬组织修复材料及其制备方法。其中硬组织修复材料主要由无机钙盐和光固化高分子材料组成。特别涉及一种含寡聚磷酸钙（CPO）的聚乙二醇二丙烯酸酯（PEGDA）水凝胶材料及其制备方法。首次将CPO与PEGDA以一定比例复合，使用光引发剂（LAP或I2959），制备出机械强度较高、生物相容性优良的可注射水凝胶材料。利用模具法或三维（3D）打印技术进一步将水凝胶材料加工形成不同形状的立体结构，用于临床硬组织（如骨组织、牙组织）缺损修复。该材料具有适应性强、安全系数高、使用方便快捷、应用前景广阔等特点。

A METHOD OF DESIGNING AN ORTHODONTIC APPLIANCE FOR MOVING ONE OR MORE TEETH OF A PLURALITY OF TEETH, AND SYSTEM TO GENERATE A PLURALITY OF SUCH APPLIANCES.

Resumen de: US2025152310A1

A dental appliance may include a first plurality of tooth receiving cavities for anterior teeth and a first plurality of attachment receiving cavities shaped to impart a first plurality of forces and a first counter moment to the anterior teeth, the first plurality of forces being to direct at least one tooth in a posterior direction. The dental appliance may include a second plurality of tooth receiving cavities for posterior teeth and a second plurality of attachment receiving cavities to impart a second plurality of forces and a second counter moment the posterior teeth, the second counter moment being in a direction opposing the first counter moment. At least a portion of the second plurality of forces may be configured to oppose the first plurality of forces. The first counter moment and the second counter moment may be configured to be coupled to form a differential moment.

THREE-DIMENSIONAL IMPLANT WITH HYDROPHILIC SURFACE

Resumen de: AU2024289833A1

The disclosure provides a 3D tissue reconstruction implant having a hydrophilic implant surface and consisting of a bio-resorbable material, wherein the implant surface is considered hydrophilic when assessed using an ink test following ISO 8296:2003 and adapted to a 3D surface, wherein said ink test comprises incubating the implant for 1 min in a solution consisting of an ink with a surface tension of 72 mN/m and water and wherein after incubation of the implant in said solution an ink colored implant surface is indicative for a hydrophilic implant surface. The disclosure also provides said implant for use in tissue reconstruction, (soft) tissue support, tissue augmentation and/or implant revision and the use of said implant for reconstructing, augmenting and/or revising a tissue and/or supporting a (soft) tissue, respectively, wherein the implant is inserted into a patient. Further the disclosure provides a method of manufacturing a tissue reconstruction implant with a hydrophilic implant surface.

FABRICATION METHOD AND SYSTEM FOR LPBF MAGNESIUM-ALLOY TISSUE-ENGINEERING SCAFFOLD WITH SMOOTH INNER SURFACE

Resumen de: WO2026031699A1

Provided in the present invention are a fabrication method and system for an LPBF magnesium-alloy tissue-engineering scaffold with a smooth inner surface. The method comprises: step S1, scanning a porous scaffold, and performing screening to obtain infill scanning parameters, which can achieve the greatest density, wherein the scanning comprises single-pass contour scanning and single infill scanning; step S2, on the basis of said infill scanning parameters, optimizing a contour scanning strategy; step S3, acquiring a corresponding molten-pool size, and using the optimized contour scanning strategy to adjust a spot compensation value; and step S4, on the basis of the contour scanning strategy and the adjusted spot compensation value, fabricating a magnesium-alloy tissue-engineering scaffold. In the present invention, the defects of powder adhesion and dross formation in a complex porous structure which seriously affect the inner surface roughness and the scaffold performance are eliminate in situ during fabrication, such that the fluidity, fatigue resistance and corrosion resistance of a porous scaffold are improved, cumbersome post-processing procedures are simplified, and the production cost is reduced, thereby achieving the concept of green production.

DENTAL RESTORATION MOLDS

Resumen de: US20260041530A1

A custom tool for forming a dental restoration in a patient's mouth includes a facial mold body and a lingual mold body, each configured for a patient-specific, customized fit with respective sides of at least one tooth. The facial and lingual mold bodies each include restorative portions and engagement portions that interlock at locations offset from a mold cavity formed between the restorative portions. The engagement portions are dimensioned to produce a residual seating pressure that maintains the mold bodies in a clamped state when interlocked, facilitating accurate shaping of restoration material within the mold cavity. The tool may include apertures for injection of restorative material, hinged doors or plugs for sealing, and vents for controlling material flow. The device and associated methods enable the digital design and fabrication of custom dental restoration molds for single or multiple teeth, improving restoration quality and reducing overall clinical or procedural complexity.

ORTHODONTIC BRACKET AND BRACKET SUPPORT SYSTEM AND METHOD

Resumen de: US20260041526A1

An orthodontic bracket and bracket support system, and its method of manufacture and use is provided. The system includes a bracket assembly including one or more bracket members to be bonded to a patient's teeth, a placement guide assembly including one or more placement members to properly position the bracket members for the bonding procedure, and a support assembly to support the bracket assembly and/or the placement guide assembly during manufacture and use. The bracket assembly, the placement guide assembly, and the support assembly are formed together and in combination using stereolithography three-dimensional (3D) printing.

SHAPE MEMORY POLYMER-BASED DEVICES AND METHODS OF USE IN TREATING INTRACORPOREAL DEFECTS

Resumen de: US20260041435A1

A novel shape memory polymer (SMP)-based device for surgical treatment of an intracorporeal defect (e.g., a void or anomaly) such as an intracranial aneurysm or fistula. In at least one non-limiting embodiment, the SMP device is a 3D-printed SMP material sized to specifically fit and thus occlude an intracranial aneurysm (ICA). The SMP device may be delivered to the intracorporeal defect via a catheter having a heating mechanism wherein the SMP device is raised above its glass transition temperature as it is deployed, causing the SMP device to return to its permanent shape after it is deployed into the intracorporeal defect. SMP device delivery systems that include the SMP devices, as well as methods of making and using the devices and systems, are also disclosed.

NEGATIVE POISSON'S RATIO MATERIALS FOR THERMAL AND RADIATION THERAPY SEEDS

Resumen de: US20260041923A1

A biocompatible seed for implantation in tissue of a patient includes an elongated body sized and shaped to be at least partially inserted into the tissue of the patient, in which the body includes a negative Poisson's ratio (NPR) material having a Poisson's ratio of between 0 and −1. The seed can be a thermal seed configured to generate heat responsive to exposure to a magnetic field. The seed can be a seed for brachytherapy that includes an inner layer including a radioactive material and an outer layer including the NPR material.

VALVE ASSEMBLY FOR MEDICAL PROCEDURES

Resumen de: US20260041901A1

The invention relates to a valve used in medical procedures. More specifically the invention relates to an introducer sheath valve used in minimally invasive and conventional surgical procedures. The valve may accommodate a wide range of surgical implement diameters, shapes, and multiple implements without imposing the high frictional forces of known valves.

METHOD OF MANUFACTURING DIABETIC FOOT PATIENT-SPECIFIC DERMAL REGENERATION SHEET AND DIABETIC FOOT PATIENT-SPECIFIC DERMAL REGENERATION SHEET MANUFACTURED USING THE SAME

Resumen de: US20260041717A1

The specification relates to a method of manufacturing a diabetic foot patient-specific skin regeneration sheet, and a diabetic foot patient-specific skin regeneration sheet. The method includes extracting autologous adipose tissue, removing fibers in the autologous adipose tissue, crushing the autologous adipose tissue, and acquiring an adipose tissue extract by filtrating the crushed autologous adipose tissue.

BIOENGINEERING PATIENT-SPECIFIC 3D-PRINTED CARTILAGE IMPLANTS

Resumen de: US20260041558A1

The invention related to an implant comprising a scaffold comprising at least one first area characterized by micropores and at least one second area characterized by macropores, wherein said at least one second area is defined by being expected to be exposed to higher pressures and/or forces when compared with said at least one first area, and methods thereof.

Additive Manufacturing Part Support and Handling Frame

Resumen de: US20260041436A1

A cutting instrument including an insert and a frame having sidewalls that extend from a base and define a slot. The slot is configured to receive a portion of the insert such that an edge of the insert extends beyond the frame. The sidewalls are configured to shrink around a portion of the insert such that an edge of the insert extends beyond the frame. Additionally, a method for fabricating a cutting instrument including depositing layers of metal powder onto a base and selectively binding the deposited layers of the metal powder onto the base to form a frame attached to the base. Next, placing an insert within the frame such that a portion of the insert extends beyond the frame and the combination of the base, the frame, and the insert forms an in-process assembly.

Breath-Enhanced Jet Nebulizer for HFNC Therapy

Resumen de: US20260041860A1

A system and method for enhanced aerosol drug delivery during high flow nasal cannula (HFNC) therapy. The system comprises a breath enhanced jet nebulizer (BEJN) connected to a high flow medical breathing gas supply supplying breathing gas to the BEJN at flow rates of 5 L/min to 60 L/min, a nebulization gas supply, a drug infusion device that supplies a drug solution to the nebulizer for the delivery of nebulized drug to a patient. All the breathing gas and nebulized drug solution delivered to the patient passes through the BEJN. The rate of drug delivery increases with increases in the flow rate of the medical breathing gas supply and increases in infusion pump flow rates. The drug solution infusion rate is between 5 mL/hour and 50 mL/hour. This system and method enable efficient aerosol drug delivery to patients during HFNC therapy for prolonged periods, improving treatment outcomes.

IMPLANTS COMPRISING A SILICONE FOAM

Resumen de: US20260041814A1

The present invention relates to new implants, especially breast implants, which are bio-durable, biocompatible, which provide a soft tissue feel, and having a reduced density. Said implants comprise a shell and a filling enclosed by the shell, wherein the filling comprises a silicone foam obtained from a blowable crosslinkable silicone composition comprising an organopolysiloxane having at least two alkenyl groups bonded to silicon per molecule, an organosilicon compound having at least two and preferably at least three hydrogen atoms bonded to silicon per molecule, a hydrosilylation catalyst, at least one porogenic agent which is water, hydrogel, or an aqueous silicone emulsion, at least one chemical blowing agent, and a linear polydimethylsiloxane.

THREE-DIMENSIONAL RECONSTRUCTION METHOD, ELECTRONIC DEVICE AND STORAGE MEDIUM

Resumen de: US20260045040A1

The present application provides a three-dimensional reconstruction method, an electronic device and a storage medium, the method includes obtaining a first image frame set of an oral cavity in a first state, where the oral cavity in the first state indicates that at least one actual scan body is installed in the oral cavity. A scan body area of each image frame in the first image frame set is identified. Once multiple image frames in the first image frame set are spliced and constructed based on feature information of the scan body area, the target three-dimensional data corresponding to the actual scan body in the oral cavity is obtained.

SYSTEMS AND METHODS FOR SELECTIVE SHAPE TRANSFORMATION OF 3D-PRINTED MATERIALS

Resumen de: US20260042889A1

Shape-restoring materials, as well as techniques for generating shape-restoring materials, are described. An example method includes generating a construct by exposing, to UV-visible light, a resin comprising a globular protein, a water-soluble co-monomer, light-to-heat converting nanoparticles, water, and a photoinitiator. At least a portion of the water is removed from the construct. The construct is converted from a first shape to a second shape by applying a force to the construct. The construct is reverted to the first shape in response to being exposed to NIR light, due to the absorption of the NIR light by the nanoparticles.

MEDICAMENT DELIVERY TRAY TO TREAT DENTAL DISEASE AND PRESERVE DENTAL IMPLANTS

Resumen de: WO2026035745A1

The present disclosure provides an improved medicament delivery tray for treating dental disease and preserving dental implants in vivo, and methods of its use. The disclosure also provides methods for automated manufacturing of said medicament delivery tray. Furthermore, the disclosure contemplates various medicament gel compositions to be used in conjunction with the medicament delivery tray.

INVERTED CONTACT-AIDED ROLLING ELEMENT MECHANISMS AND DEVICES

Resumen de: WO2024211902A1

Inverted contact-aided rolling element mechanisms and devices are discussed herein. In various embodiments, the contact-aided compliant mechanism includes a first rigid component, a second rigid component, a first flexible component, a second flexible component, each of the first and second flexible components comprising a first end, a second end, and a third end, and the first and second flexible components disposed between the first and second rigid components.

IMPLANT

Resumen de: AU2024241734A1

This invention relates to an implant (10), including a support arrangement (12) manufactured from a form of a porous material, for receiving and supporting stem cells (14) in a supported condition, for receiving a medium in the form of a neural basal and neural induction medium mixture (20) and the support arrangement (12) being shaped and sized to conform to and be received complementally by an implant zone (16). The implant zone (16) being a space defined by an excised portion of a subject's spinal cord (18). The neural basal and neural induction medium mixture (20) provides nutrients for the development of the stem cells (14) and the growth factors, in form of neurotrophin 3, neurotrophin 4 and brain-derived neurotrophic factor (BDNF) encourage and control development of the stem cells (14), the growth factors typically being constituents of the medium mixture (20).

A BIOACTIVE POLY(LACTIC-CO-GLYCOLIC ACID) (PLGA) MATERIAL, RELATED PRINTED STRUCTURE AND RELATED METHODS THEREOF

Resumen de: WO2024181920A1

There is provided a regenerative material for treatment of wounds, the material comprising: (i) a base poly(lactic-co-glycolic acid) (PLGA); (ii) a bioactive poly(lactic-co-glycolic acid) (PLGA) copolymer; and (iii) pores patterned on said material. Also provided are a medical device comprising said regenerative material, medical uses of said regenerative material, and a method of preparing said regenerative material.

NOVEL PROCESS

Resumen de: WO2024201321A1

The present invention relates to a process for obtaining a dental prosthesis comprising a crown and tooth root. Said process comprises at least one step of directing undifferentiated cells or keratinocytes and at least one three-dimensional printing step, preferably 3D bioprinting of the dental prosthesis. Furthermore, the invention regards the dental prosthesis obtained with the process and a bioink suitable for three-dimensional printing (3D), preferably suitable for 3D bioprinting.

CONTROL OF HEATING AND COOLING IN 3D BIOPRINTING

Resumen de: GB2629895A

3D printing assembly 10, suitable for bioprinting, the assembly including an enclosure 100 defining an enclosure internal area 101, a printer 200 enclosed within the internal area, the printer comprising a printer bed 240, the enclosure comprising plural sides 110, one or more of said sides having at least one temperature regulator element 112 in or on the respective side 110, wherein the or each temperature regulator element is arranged to introduce heat energy into, and/or remove heat energy from the internal area 101, and wherein the printer bed has at least one bed temperature regulator element 242 in or on the printer bed further arranged to introduce heat energy into, and/or remove heat energy from the printer bed, the sides formed from spaced apart panels and the temperature regulator element is mounted between the panels. The temperature control may be aided by air flow from a fan 130 or the like. The wall and/or bed temperature regulator element(s) maybe Peltier type devices. Bioink storage 210 maybe provided. Plural temperature sensors (TP1,TP2 and TP3) maybe provided. An enclosure for enclosing a 3D printer and a controller for a 3D printer are also provided.

DENTAL-TREATMENT INDEX, DENTAL-TREATMENT INDEX FIXING HOLDER, DENTAL-TREATMENT SET, METHOD FOR GENERATING THREE-DIMENSIONAL DATA OF DENTAL-TREATMENT INDEX, AND DATA FOR PREPARING DENTAL-TREATMENT INDEX

Nº publicación: EP4691414A1 11/02/2026

Solicitante:

AMIDEX INC [JP]
Amidex, Inc

Resumen de: EP4691414A1

Provided is a dental-treatment index that enables high-quality tooth crown restoration regardless of the skill of a practitioner. A dental-treatment index 10 according to the present invention is composed of a material through which light transmits, and has two fixing outer surfaces 13 and a tooth-shaped hole 14 provided in an internal surface 11a between said two fixing outer surfaces 13. Each of the fixing outer surfaces 13 is provided with a guide part 13a. A dental-treatment index fixing holder 20 is composed of a material through which light transmits, and has two holder lateral surface parts 22 that are coupled to each other. In the two holder lateral surface parts 22, fixing inner surfaces 23 facing each other have guided parts 23a provided thereto.