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METHOD FOR PRODUCING ORGANOIDS, ORGANOIDS PRODUCED WITH THIS METHOD, AND USE THEREOF

Resumen de: WO2025181738A1

A method for producing organoids, wherein: a hydrogel containing cells and optionally a photoinitiator is subjected to a bioprinting process at a temperature within a range of 20-30°C, a pressure within a range of 40-75 kPa, and a constant extrusion rate of 10 mm/s, wherein the printed hydrogel is directed into a vessel containing oil, and then the resulting hydrogel capsule in an oil layer is transferred to a sieve and washed with hexane and a cell medium. Organoids produced with this method, and use thereof.

VASCULARIZED BONE ORGANOID AND CONSTRUCTION METHOD THEREFOR

Resumen de: WO2025179532A1

Provided are a vascularized bone organoid and a construction method therefor. By combining a suspension-based three-dimensional (3D) bioprinting method, a cell-laden printing strategy, and a sacrificial bioink material, a vascularized bone organoid model containing a hollow vascular network is constructed. The vascularized bone organoid model has excellent structural stability, mechanical properties, growth and development capability, and osteogenic capability, involves simple selected materials and fabrication process, implements engineered stable production, allows for long-term co-culture of cells for 3D cultivation, and has high applicability and research potential.

METHOD FOR GENERATING DENTAL CROWN MODEL AND SYSTEM FOR GENERATING DENTAL CROWN MODEL

Resumen de: WO2025180497A1

Provided are a method for generating a dental crown model and a system for generating a dental crown model. The method for generating a dental crown model comprises: retrieving preset tooth model data according to a target position of a tooth to be treated, wherein the preset tooth model data comprises a plurality of geometrical features; adjusting a preset tooth model by using a plurality of tooth model parameters to obtain adjusted geometrical features; give scores of the matching degree between the adjusted feature points and a plurality of conditional operations; performing weighted operation on the scores to obtain a false tooth score; if the false tooth score is less than a threshold score, inputting the false tooth score into an artificial intelligence unit for parameter correction to obtain a plurality of new tooth model parameters, and continuing adjustment until the false tooth score is greater than the threshold score; and using a tooth model corresponding to final parameters as a dental crown model of a patient.

PREPARATION METHOD FOR 3D BIOPRINTED TRACHEAL SUBSTITUTE LOADED WITH EPCS

Resumen de: LU509884B1

The invention provides a preparation method for a 3D bioprinted tracheal substitute loaded with EPCs, which includes steps of: S1, preparing a complete decellularized tracheal extracellular matrix free of immunogenicity; S2, preparing an LAP-NC-dtECM hydrogel; S3, isolating and culturing EPCs; S4, preparing an LAP-NC-dtECM bioprinting ink loaded with EPCs; S5, preparing the 3D bioprinted tracheal substitute loaded with EPCs. Combining an acellular trachea to retain complete natural extracellular matrix components, cell nuclei and immune substances are effectively removed so that the invention has excellent characteristics such as being free of immunogenicity, good biocompatibility and the ability to effectively induce angiogenesis in vivo. The invention is prepared into a hydrogel and added with bone marrow EPCs to prepare a printable bioprinting ink, so as to reconstruct a biomimetic tracheal stent with good biomechanical properties and angiogenesis properties in combination of the 3D bioprinting technology.

SOLID DOSAGE FORM PRODUCTION

Resumen de: US2025275927A1

The present invention provides methods of preparing solid dosage form, particularly pharmaceutical dosage forms, using extrusion and 3D-printing, as well as the solid dosage form itself, the compositions used to make said items, uses of the solid dosage forms, and containers used in their preparation.

SYSTEMS AND METHODS FOR RAPID LIQUID BIOPRINTING

Resumen de: WO2025181649A1

Methods for fabricating three-dimensional (3D) constructs from a mixture of cells, culture medium, and a scaffold material with a controlled calcium chloride concentration is disclosed. The process involves positioning a nozzle within a gel composed of alginate solution. The nozzle is then moved within the gel, releasing the cell-media-scaffold mixture in a controlled pattern. As the mixture is deposited, it becomes surrounded by the gel, which provides structural support until it solidifies through the cross-linking reaction between the calcium chloride in the cell-media-scaffold mixture and the alginate solution. This results in the formation of a solid 3D structure that incorporates the cells and their supporting scaffold. The presented method offers a versatile platform for generating intricate cell-based 3D constructs with precise control over their composition and structure. This method can be used to produce cultivated meat with complex 3D structures as well as organelles and fully functional organs.

BIO-INSPIRED NEEDLE FOR CONTROLLED RELEASE

Resumen de: US2025276164A1

A micro-needle (MN) patch is formed as an array of 3-D bioprinted structures having a relatively hard planar base with multiple water sensitive barbed tips extending therefrom. The barbed tips are formed from a polymer material configured to exhibit reversible shrink-swell volume change in response to surrounding humidity to facilitate skin penetration under the shrinkage conditions and long-term adhesion when swelling in skin tissues.

SYSTEMS AND METHODS FOR PRINTING A CORE FIBER

Resumen de: US2025276489A1

A print head, system and method for producing hollow fiber structures, for example three-dimensional biological structures comprising living cells, includes a dispensing channel, a core channel converging with the proximal end of the dispensing channel, a first shell channel converging with the core channel and the dispensing channel at a focusing intersection or chamber, and a sheath flow channel converging with the dispensing channel at a sheath flow intersection or chamber located between the focusing intersection or chamber and the distal end of the dispensing channel. The diameter of the dispensing channel increases from a first diameter to a second diameter at the sheath flow intersection or chamber, and the core channel has a third diameter less than the first and second diameters. The sheath flow channel includes sheath flow sub-channels and the focusing chamber has a conical frustum shape.

IMPLANTS HAVING BONE GROWTH PROMOTING AGENTS AND METHODS OF USING SUCH IMPLANTS TO REPAIR BONE STRUCTURES

Resumen de: US2025275856A1

Various embodiments of implant systems and related apparatus, and methods of operating the same are described herein. In various embodiments, an implant for interfacing with a bone structure includes a web structure, including a space truss, configured to interface with human bone tissue. The space truss includes two or more planar truss units having a plurality of struts joined at nodes. Implants may be coated with or include fibers or particles to enhance bone growth around and through the implant.

DENTAL CROWN MODEL GENERATION METHOD AND DENTAL CROWN MODEL GENERATION SYSTEM

Resumen de: US2025275838A1

The present invention provides a dental crown model generation method and a dental crown model generation system. The method includes: retrieving preset dental shape data including multiple geometric features based on the target position of the treated tooth; adjusting the preset dental shape using rotation, stretching, and translation parameters to obtain the adjusted geometric features; scoring the matching degree between the adjusted geometric feature and multiple conditional operations; performing weighted calculations on the scores to obtain a denture score; if the denture score is below a threshold score, inputting the denture score into a parameter correction artificial intelligence unit to obtain new rotation, stretching, and translation parameters, and continuing the adjustment until the denture score exceeds the threshold score; and using the dental shape corresponding to the final parameters as the final dental crown model for the patient.

CURABLE COMPOSITIONS COMPRISING A POLYMERIZABLE REACTIVE DILUENT FOR FABRICATION OF ORTHODONTIC APPLIANCES

Resumen de: US2024191006A1

The present disclosure provides curable compositions comprising one or more of photo-polymerizable monomers as reactive diluents, as well as polymeric materials formed from the curable compositions. Further provided herein are methods of producing the compositions and using the same for the fabrication of medical devices, such as orthodontic appliances.

Apparatus and method for 3D printing

Resumen de: GB2638786A

3D printing of solid-dosage-forms. A printhead comprising one of an integrated powder dispenser or an integrated peristaltic pump 11, where the printhead may be interchangeable and may comprise a multi-tip array. A 3D printer comprising one or more of the printheads. The peristaltic pump may comprise a thermostatic peristaltic pump and tubing 13 for pumping at up to 160 °C, a temperature controlled chamber 12 for storing semi-solid material, and may comprise dispensing tips 15 for simultaneous printing of multiple items. 3D printing apparatus comprising the 3D printer and a build platform with integrated capsule holders and/or moulds. 3D printing apparatus comprising a conveyer belt and balance. Methods of manufacturing solid-dosage-forms comprising use of the 3D printer to print semi-solid material at up to 160 °C, fill capsules or moulds, or print multiple items simultaneously.

CONTINUOUS MID-AIR 3-DIMENSIONAL PRINTING FOR PHARMACEUTICAL DOSAGE FORMS

Resumen de: WO2024092237A1

Described are continuous manufacturing methods using 3D printing or any similar additive manufacturing technology to produce pharmaceutical dosage forms or pharmaceutical delivery devices. Manufacturing methods using hot-melt extrusion to fabricate filaments for fused deposition modeling (FDM) based 3D printing are disclosed. Methods using FDM based 3D printing to fabricate printed products suitable for pharmaceutical delivery purposes are disclosed. The printed products may have various shapes and configurations.

FEM ANALYSIS FOR THE PRODUCTION OF DENTAL RESTORATIONS

Resumen de: EP4609823A1

Die vorliegende Erfindung betrifft ein Verfahren zum Aufbauen einer dentalen Restauration, mit den Schritten eines Bereitstellens (S101) eines dreidimensionalen Datensatzes, der die räumliche Form der dentalen Restauration und eine räumliche Verteilung zumindest eines Herstellungsmaterials innerhalb der dentalen Restauration angibt; eines Simulierens (S102) einer räumlichen Spannungsverteilung innerhalb der dentalen Restauration bei einer vorgegebenen Belastung auf Basis des dreidimensionalen Datensatzes; und eines Veränderns (S103) des dreidimensionalen Datensatzes auf Basis der simulierten Spannungsverteilung.

FEM ANALYSIS FOR THE PRODUCTION OF DENTAL RESTORATIONS

Resumen de: EP4609822A1

Die vorliegende Erfindung betrifft ein Verfahren zum Aufbauen einer dentalen Restauration, mit den Schritten eines Bereitstellens (S101) eines dreidimensionalen Datensatzes, der die räumliche Form der dentalen Restauration und eine räumliche Verteilung zumindest eines Herstellungsmaterials innerhalb der dentalen Restauration angibt; eines Simulierens (S102) einer räumlichen Spannungsverteilung innerhalb der dentalen Restauration bei einer vorgegebenen Belastung auf Basis des dreidimensionalen Datensatzes; und eines Veränderns (S103) des dreidimensionalen Datensatzes auf Basis der simulierten Spannungsverteilung.

細胞微小区画における細胞外マトリックス代替物

Resumen de: CN119731304A

The present invention relates to a clinically usable "GMP" compliant cell microcell comprising at least: a. A cellular layer, b. An outer hydrogel layer, and c. A fibrin web disposed between the outer hydrogel layer and the cellular layer. The invention also relates to a method for producing such a microcompartment and to the use of a kit for producing a cell microcompartment comprising a fibrinogen solution and a thrombin solution.

ARRANGEMENT AND METHOD FOR MANUFACTURING A PLURALITY OF ORTHODONTIC APPLIANCES

Resumen de: MX2025009432A

The invention relates to an arrangement for manufacturing a plurality of orthodontic appliances (1) in parallel, comprising an additive printing machine (2) comprising a build platform (4) and configured for additively manufacturing a plurality of teeth models (9) in parallel, a plurality of plates (6) each configured for teeth model printing by the additive printing machine (2), whereby each plate (6) comprises a unique machine-readable identifier (13) and each plate is detachable and precisely fixed to the build platform (4), and a thermoforming machine (10) configured for thermoforming a thermoformable material (11) over the plurality of teeth models (9) for receiving the plurality of orthodontic appliances (1).

COATING COMPOSITION FOR ORTHODONTIC APPLIANCE AND COATING METHOD USING THE SAME

Resumen de: KR20250131201A

본 명세서에서는 치과 교정장치를 3D 프린터를 이용하여 프린팅하는 단계; 프린팅된 상기 치과 교정장치를 후속 큐어링(post curing)하는 단계, 및 상기 치과 교정장치 상에 방오 코팅층이 형성되도록, 후속 큐어링된 상기 치과 교정장치를 공중합체 용액(copolymer solution)에 침수시키는 단계,를 포함하는, 치과 교정장치용 코팅 조성물을 이용한 코팅 방법을 제공한다.

Oral device to inhibit mastication and ingestion of solid food

Resumen de: US12403025B1

The present invention is oral device that inhibits mastication and ingestion of solid food while minimizing intrusiveness and discomfort in other oral activities. This device is ideal for individuals following an all-liquid diet without relying on willpower alone. The oral device allows a full range of motion of the jaw and the wearer keeps the ability to open and close the mouth, allowing all oral functions other than chewing and swallowing solid food. In various embodiments of the invention, the oral device comprises a set of retainers worn over teeth or retainer bars bonded to, or integrated as part of the retainers. A set of flexible mastication barriers coupled to the retainers or retainer bars and extending from mandible to the maxilla on the lingual side of the mouth inhibit the movement of solid food to the occlusal surfaces of the posterior teeth for chewing. An artificial intelligence platform is implemented to improve fabrication of the oral device and predict and eliminate undercuts in the retainers or retainer bars.

一种个性化治疗冠心病的血管支架及其制备方法

Resumen de: CN120570719A

本发明公开了一种个性化治疗冠心病的血管支架及其制备方法，所述制备方法包括如下步骤：S1、根据患者的基本信息、临床表现症状和CT扫描数据，对患者的冠状动脉情况进行分析评估，判断应采用的治疗方式；S2、结合患者的冠状动脉情况，针对患者情况设计出尺寸合适的血管支架，建立不同降解状态下的血管支架模型，对血管支架进行径向支撑性能有限元模拟测试和血流动力学模拟测试，确定适合病人个性化治疗的血管支架数据；S3、根据确定的血管支架数据，选择血管支架材料，根据血管支架尺寸和所选血管支架材料来制备血管支架。本发明能有效地实现冠心病患者的个性化治疗，提高血管支架介入治疗的效果，减少患者的经济成本。

一种用于治疗肝衰竭的原位生物3D打印人工肝脏贴片的构建方法

Resumen de: CN120571067A

本发明属于生物医学领域，具体涉及一种用于治疗肝衰竭的原位生物3D打印人工肝脏贴片的构建方法。本发明人工肝脏贴片主要成分是复合水凝胶，包括透明质酸(HA)、明胶(Gelatin)、海藻酸钠(sodium alginate)、甲基丙烯酰化明胶(GelMA)。复合水凝胶具有良好的3D打印性能，通过生物3D打印可实现人工肝脏贴片的规模化构建，为可移植的生物人工肝组织提供了一个潜在的解决方案。本发明所述人工肝脏贴片采用挤出式打印模式，成型速度快，并且内部的肝脏细胞仍能保持较高活性，可保证肝脏基础功能(糖原储存、药物代谢和分泌蛋白的合成等)的重建，在治疗肝功能衰竭疾病中具有重要潜力。

一种基于金字塔结构的鼻整形支撑系统

Resumen de: CN120570728A

本发明涉及医疗美容器械技术领域，且公开了一种基于金字塔结构的鼻整形支撑系统，包括金字塔基元模块、三维桁架系统、梯度孔隙基座、性能参数单元、3D打印参数设置模块、智能适配组件和智能监测模块，金字塔基元模块包括微金字塔结构单元，通过集成了金字塔基元模块、三维桁架系统、梯度孔隙基座、性能参数单元、3D打印参数设置模块、智能适配组件和智能监测模块，形成了一个高度集成化、智能化的鼻整形支撑解决方案，不仅提高了鼻整形手术的精准度和个性化程度，还大大增强了手术的安全性和效果，提高了结构稳定性，避免了在受剪切力时易偏转和单点支撑导致鼻尖皮肤具有穿透风险的情况发生，提高了血管化速率。

一种唇颊侧及腭侧双固位骨膜下种植体支架及制作方法

Resumen de: CN120570701A

本发明公开了一种唇颊侧及腭侧双固位骨膜下种植体支架及制作方法，种植体支架包括双固位支架主体，双固位支架主体上一侧设有固定于唇颊侧的螺钉孔，双固位支架主体上另一侧设有固定于腭侧的螺钉孔，双固位支架主体的中部设有多个种植基台；双固位支架主体通过扫描数据重建患者完整颌骨结构，提取唇颊侧与腭侧骨面轮廓，得到基础支架模型，然后通过三维有限元分析，对种植基台的布局结合应力分布结果以及唇侧与腭侧的螺钉孔位进行优化，然后采用拓扑优化方法，并通过3D打印制造得到种植体支架。本发明在保证刚度和耐用性的同时，整体结构更加轻便，使用的螺钉数量更少，从而减轻患者佩戴时的压力，显著提高支架的使用寿命，减少压力性损伤的风险。

伤口敷料及其制备方法

Resumen de: CN120572672A

本发明涉及伤口敷料及其制备方法，包括以下步骤：S1、获取伤口三维尺寸，得到伤口模型；S2、根据伤口模型设计阳模，所述阳模包括基板和设置在基板一侧的多个微针模型，所述微针模型位于伤口模型内，且所有微针模型的尖端均处于伤口三维模型的伤口面上；S3、制备步骤S2设计的阳模；S4、利用阳模倒模制备PDMS微孔模具；S5、将负载药物的水凝胶前驱体溶液注入PDMS微孔模具，得到伤口敷料。本发明的伤口敷料，各个微针的长度与伤口的深度相匹配，使得各个微针的尖端能够有效接触到伤口面，从而有效传递药物，保证伤口的恢复效果。

一种梯度异质结构锌合金植入物及其激光增材制备方法

Nº publicación: CN120572021A 02/09/2025

Solicitante:

江西理工大学

Resumen de: CN120572021A

本发明公开了一种梯度异质结构锌合金植入物及其激光增材制备方法，首先构建梯度异质结构的三维模型，并经分层切片处理后导入选区激光熔化系统。以切片层为调控单元，在优化的激光能量密度范围内进行动态参数切换：高激光能量密度通过提升熔池热力学条件促进粗大晶粒生长，而低激光能量密度则通过急速冷却实现细小晶粒调控，最终形成具有周期性粗细晶层交替的梯度异质结构。结果显示梯度异质结构锌合金植入物展现出强度与延性的协同提升，其强化机制主要源于非均匀变形引起的应力、层间位错以及粗细晶粒交替层抑制应变局部化的综合作用。此外，该植入物还展现出优异的梯度抗菌作用。这为高性能锌合金植入物的设计和开发提供了可行的策略。