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MULTI-FUNCTIONAL POLYMERIZABLE COMPOUNDS AND METHODS OF PRODUCING AND USING THE SAME

Resumen de: WO2026080633A1

The present disclosure provides synthesizing multi-functional polymerizable compounds and methods for the synthesizing the same. The methods include reacting a compound of Formula (Ia) with an epoxide of Formula (Ib) with quantitative conversion, requiring only an aqueous work-up for purification. Further provided herein are methods of producing polymerizable composition, methods of forming an article by additive manufacturing processes (e.g., via 3D printing), such as orthodontic appliances with increased stain resistance.

3D STRUCTURE-FUNCTIONAL DESIGN OF BIOMASS-DERIVED SOLAR PHOTOCATALYST FOR ANTIMICROBIAL EFFICACY AND CHEMICAL DEGRADATION AT AMBIENT CONDITIONS

Resumen de: US20260102758A1

The subject invention pertains a stable, three-dimensional (3D) photocatalyst composition comprising TiO2 doped with carbon derived from lignin. The photocatalyst composition has a stable, hollow, spherical or spheroid nanoparticle structure, which improves photodegradation under visible light irradiation over unmodified TiO2 photocatalysts. The subject invention also provides methods of preparing the photocatalyst, as well as methods using the photocatalyst to remediate contaminants such as pharmaceuticals, pathogens and persistent organic pollutants.

SYSTEM AND METHODS FOR LOCATING DRIVERS OF ATRIAL FIBRILLATION

Resumen de: US20260102102A1

The present disclosure applies to methods of cardiac ablation that use an algorithm to determine where in the heart a driver of atrial fibrillation is located. Catheters with multi-electrode arrays are used to measure electrograms from cardiac signals wherein abnormal signals are identified as electrogram deflections with characteristic shapes. The electrogram deflections are compared to each other in pairs to determine which came first in time in order to determine the net direction of propagation of a fibrillatory wave. The signal that came first is assigned a positive point value so that once the plurality of electrograms have been compared, the signal with the highest point value can be identified as a driver of fibrillation. The data can be displayed graphically as a map of atrial fibrillation drivers on a 3D representation of a heart, allowing surgeons to quickly and easily identify where on the heart the driver is.

PATHOGEN MONITORING SYSTEM AND METHOD

Resumen de: WO2026080101A2

The portable sensor system (100) includes a containment portion (102) and a sensor portion (104). The containment portion (102) may include a shipping container such as a jar. The sensor portion (104) may include a cap (106) that may be selectively coupled with the containment portion (102). The cap (106) may include a battery module (108), a processing module (110), and a sensor module (112). In a specific example, the portable sensor system (100) may be provided in four layers (a battery module layer (108), a processing module layer (110), a sensor module layer (112), and a coupling mechanism layer (114). The coupling mechanism layer (114) may be configured to selectively lock the cap (106) to the containment portion (102). In a more specific example, one or more of the layers (108, 110, 112, 114) may be 3D printed. The portable sensor system (100) may be utilized as a smart-monitoring device for the presence of a pathogenic bacteria in the shipping container.

SYSTEMS, METHODS, AND DEVICES FOR TARGET CONTROLLED INFUSION

Resumen de: US20260102564A1

0000 A system for programming infusion devices for target controlled infusion is disclosed. The system includes a docking station and one or more processors configured to determine a first infusion device docked with a docking station and accept user input of one or more of patient-specific parameters, drug-related parameters, and a desired target concentration of a therapeutic agent in a workflow on the first infusion device for programming a target controlled infusion (TCI) therapy. After receiving a particular set of parameters, the set of parameters can be copied to the second infusion device to pre-complete and bypass a number of workflow steps of a second workflow of another infusion device. When the second workflow is accessed, the number of workflow steps of the second graphical interface workflow are pre-completed and bypassed.

DEEP REINFORCEMENT LEARNING BASED ROBUST NEUROVASCULAR MAPPING

Resumen de: US20260105597A1

Systems and methods for generating a patient-specific vascular tree are provided. 1) one or more medical images of a patient and 2) a vascular tree template comprising a plurality of points are received. The plurality of points of the vascular tree template are iteratively adjusted based on the one or more medical images using one or more AI (artificial intelligence) agents to generate a patient-specific vascular tree for the patient. The patient-specific vascular tree is output.

Systems and Methods for Determining the Orientation of Motion-Sensing Devices During Physical Activity

Resumen de: US20260102656A1

0000 A computer-implemented method for providing real-time performance feedback includes receiving uncalibrated time-series motion data generated by one or more motion sensors coupled directly or indirectly to an athlete while performing a downhill snow sport, the motion sensor(s) having an unknown rotational orientation relative to the athlete; determining an estimated rotational offset of the motion sensor(s) relative to a body-segment coordinate frame of the athlete, the rotational offset determined using a calibration model; transforming, by the one or more processors, the uncalibrated time-series motion data to calibrated time-series motion data according to the estimated rotational offset, the calibrated time-series motion data aligned with the body-segment coordinate frame; and processing the calibrated time-series data, with the one or more processors, to determine one or more metrics for the athlete.

SMART RING DEVICE FOR IDENTIFYING POSTURE OF USER

Resumen de: WO2026079901A1

According to an embodiment, a smart ring device may comprise a housing comprising a first surface for contacting a portion of a user's body and a second surface opposite to the first surface. The housing may comprise a conductive portion disposed to surround the portion of the user's body along the second surface. The smart ring device may comprise: a radio frequency (RF) coupler connected to the conductive portion; a memory including instructions and including one or more storage media; and at least one processor including a processing circuit. The instructions, when executed individually or collectively by the at least one processor, may cause the smart ring device to obtain impedance information about the conductive portion on the basis of a feedback signal obtained through the RF coupler while a signal is transmitted or received through the conductive portion. The impedance information may be used as input data for an artificial intelligence model configured to identify the posture of the portion of the body.

MEDICAL DEVICE

Resumen de: WO2026079016A1

A medical device 1 is used with a consumable 2 attached thereto. The consumable 2 has a usage time limit stipulated, and the consumable 2 has an information presentation unit 21 for presenting individual identification information of the consumable 2. The medical device 1 includes a reading unit 3 for reading the individual identification information from the information presentation unit 21, and a consumable management unit 41 that, on the basis of the individual identification information presented by the information presentation unit 21, monitors usage time of the consumable 2 and determines whether the usage time of the consumable 2 has reached the usage time limit.

SYSTEM AND METHOD FOR MANUFACTURING AN X-RAY BONE PHANTOM

Resumen de: US20260102135A1

A computer-implemented method for manufacturing an X-ray bone phantom is provided. The computer-implemented method includes obtaining, via a processing system comprising one or more processors, dual-energy scan data from one or more dual-energy scans of an ex vivo bone phantom. The computer-implemented method also includes converting, via the processing system, the dual-energy scan data into a two-dimensional image. The computer-implemented method further includes printing, via the processing system, a semi-anthropomorphic X-ray bone phantom made of aluminum based at least on the two-dimensional image, wherein the semi-anthropomorphic X-ray bone phantom is configured to provide quantitative areal bone mineral density and a realistic projected bone morphology for image quality assessment and lateral distance measurements during calibration.

3D BIOPRINTING PLATFORM FOR GENERATION OF FUNCTIONAL PRIMARY AND HPSC-DERIVED ORGANOIDS IN HYDROGEL CONSTRUCTS

Resumen de: WO2026080718A1

The disclosed concept includes the preparation and use of biocompatible bioinks, as well as techniques and methods therein for bioprinting, preparing and 3D printing primary cells and patient-specific cells and forming functional soft tissue in a three-dimensional construct form that incorporates the cells and mimics native tissues. The biocompatible bioinks include alginate, methylcellulose, and primary or iPSC-derived cells in the form of single cells or aggregates. The bioprinted 3D construct includes one or more of the iPSC organoids, human islets, as well as TEPCs.

VOICE CONTROL IN A HEALTHCARE FACILITY

Resumen de: US20260105916A1

0000 ice control of medical devices in a healthcare facility are disclosed herein. The systems employ continuous speech processing software, voice recognition software, natural language processing software, and other software to permit voice control of the medical devices. Systems are also provided for distinguishing which medical device from among multiple medical devices in a patient room is the particular medical device to be controlled by voice input from a caregiver or a patient.

MOBILE DEFIBRILLATOR

Resumen de: US20260102624A1

0000 Systems and methods for controlling a mobile defibrillator (AED) unit are provided.

CONTINUOUS GLUCOSE MONITOR COMMUNICATION WITH MULTIPLE DISPLAY DEVICES

Resumen de: US20260104835A1

0000 A continuous glucose monitor for wirelessly transmitting data relating to glucose value to a plurality of displays is disclosed, as well as systems and methods for limiting the number of display devices that can connect to a continuous glucose transmitter. In addition, security, including hashing techniques and a changing application key, can be used to provide secure communications between the continuous glucose transmitter and the displays. Also provided is a continuous glucose monitor and techniques for authenticating multiple displays, providing secure data transmissions to multiple displays, and coordinating the interaction of commands and data updates between multiple displays.

APPARATUS FOR MONITORING, REGULATING, OR CONTROLLING FLUID FLOW

Resumen de: US20260102555A1

An apparatus, system and method for regulating fluid flow are disclosed. An apparatus for infusing fluid into a patient includes a housing, a tube-contact member, a rotating arm, and a tube-retention cover. The housing has an opening on a front side of the housing. The opening is sized to receive a drip chamber having an inlet tube and an outlet tube. The tube-contact member contacts one of the inlet tube and the output tube of the drip chamber when inserted into the opening. The rotating arm is coupled to the tube-contact member and is configured to rotate along an axis. The tube-retention cover is configured to close when the drip chamber is initially loaded into the opening.

Mandibular Advancement Device (MAD) having adjustment features

Resumen de: US20260102276A1

0000 A dental article of manufacture comprising a first appliance, and a second appliance. The first appliance fits dentition of a patient’s lower dental arch, and the second appliance fits dentition of the patient’s upper dental arch. The first appliance has a first feature positioned at its midline and located at a given distal offset with respect to an incisal edge when fitted on the lower dental arch. Preferably, the second appliance has a second cooperating feature positioned at its midline and includes a closed cavity having a front-facing opening. The second feature is designed to mate with the first feature. To this end, the second feature is positioned to removably receive the first feature only through the facing opening. In use, the second feature retains the first feature in the closed cavity against backwards and up or down movement when the second appliance is fitted on the upper dental arch.

原発性骨腫瘍の診断支援システム、診断支援方法及び診断支援プログラム

Resumen de: JP2026065297A

0001 【課題】より精度の高い原発性骨腫瘍の診断支援の実現を提供する。 【解決手段】Ｘ線画像による原発性骨腫瘍の診断支援システムであって、前記Ｘ線画像を入力した際に畳み込みニューラルネットワークによって骨腫瘍であるかの判定結果を出力する処理手段を備え、前記畳み込みニューラルネットワークが、骨外腫瘍、骨皮質部及び骨内腫瘍の３クラスとして腫瘍存在範囲をアノテーションされた確定診断Ｘ線画像を教師データとして学習処理されたものであることを特徴とする、原発性骨腫瘍の診断支援システム。 【選択図】図１

COMPUTER IMPLEMENTED METHODS AND SYSTEMS FOR GENERATING MODELS OF BONES, AND FOR ADDITIVE MANUFACTURING OF BONES

Resumen de: EP4725455A1

The present disclosure relates to computer-implemented methods (100) for generating a virtual model of a first section of bone tissue including cortical bone tissue. The method comprises (104) obtaining microstructural cortical parameters including an indication of a number of osteons (210) and of a cross-sectional area of the osteons, a number of lamellae (212) forming the osteons, an indication of locations of osteons in the section of bone tissue and of dominance of the osteons. The method further comprises generating a virtual model using a generative design algorithm comprising (1061) defining a geometric space, (1062) generating a cortical cloud of points, (1064) segmenting the geometric space into substantially circular regions, defining an outer surface of the osteons. The method further comprises (1065) forming consecutive substantially concentric surfaces corresponding to the lamellae until the obtained virtual model satisfies boundary conditions formed by the microstructural cortical parameters.

EJECTION FRACTION FROM NON-CONTRAST COMPUTED TOMOGRAPHY

Resumen de: EP4725423A1

0001 For segmentation (310) and/or ejection fraction determination (320), photon-counting detection (100) for CECT in ES is used to create (110) virtual NCCT for machine training (130). The lack of NCCT data at ES for training (130) segmentation is overcome by use of the virtual NCCT. Since the segmentation (310) is trained (130) on non-contrast imaging at ES, accurate ES segmentation (310) from NCCT may be provided. The EF may be calculated (320) using NCCT.

CONFIGURABLE PHOTOPLETHYSMOGRAM SYSTEM

Resumen de: EP4725400A1

Methods, systems, and devices for optical signal measurement are described. A wearable electronic device may activate a first combination of optical sensors, the first combination of optical sensors including a set of transmitter sensors and a set of receiver sensors. In some cases, one or more optical sensor of the first combination of optical sensors may be positioned under a protrusion on an inner surface of the wearable electronic device. The device may measure, at the set of receiver sensors at a first time, one or more signals from the set of transmitter sensors, determine a signal quality metric associated with the one or more signals, and select a second combination of optical sensors for use at a second time based on the signal quality metric.

PATIENT SPECIFIC INSTRUMENTATION AUTOMATION PLATFORM

Resumen de: WO2024257100A2

The present invention, in some embodiments thereof, relates to a surgical guiding joint integration group (JIG) and, more particularly, but not exclusively, to a surgical guiding JIG for varus de rotation osteotomy (VDRO) procedure.

METHODS AND SYSTEMS FOR VAGINAL THERAPEUTIC DEVICE FITTING

Resumen de: EP4725409A2

0001 Pelvic organ prolapse (POP) and urinary incontinence (UI) are common, often distressing conditions, where, at present, physical non-surgical devices are fitted by best guess or trial-and-error with devices offered in a range of standard designs and sizes. However, each user is unique and accordingly methods, systems and devices providing a personal pelvic health characterization and provisioning approach are outlined that factor user specific anatomy and physiology, user lifestyle, user experiences and automated assessments into provisioning custom vaginal therapeutic devices. Further, user specific anatomy and physiology should be obtained in a reproducible manner with devices and systems that remove measurement artifacts, errors, bias etc. whilst providing the patient with an improved experience and the medical personnel with ergonomic, efficient, and easy to use systems exploiting combinations of dedicated multi-patient measurement equipment with user specific consumable items for cleanliness etc.

METHOD FOR PRODUCING A REMOVABLE DENTAL PROSTHESIS, AND REMOVABLE DENTAL PROSTHESIS PRODUCED ACCORDING TO THE METHOD

Resumen de: WO2024251724A1

The invention relates to a method for producing a first connection element of a removable dental prosthesis, said connection element being suitable for a sliding connection between a first fit surface of the first connection element and a second fit surface of a second connection element of the removable dental prosthesis. The invention is characterized in that the first connection element is produced by connecting a stability-granting material and a ductile material which forms the first fit surface in an additive multi-material manufacturing method.

BIO-PRINTED SKIN MODEL, RELATED THREE-DIMENSIONAL PRINTING PROCESS AND DIRECT PERFUSION DEVICE PROVIDED WITH SAID MODEL

Resumen de: WO2024252292A1

The bio-printed skin model (1) comprises: - at least one dermal layer (2) comprising at least one polymer matrix and a mixture of fibroblasts and endothelial cells and configured to simulate a human dermal tissue; - at least one epidermal layer (3) comprising at least one mixture of keratinocytes and configured to simulate a human epidermal tissue; wherein the dermal layer (2) comprises at least one inner duct (4) formed by fibroblasts and endothelial cells, configured to simulate a vascular channel of human skin and provided with at least two end stretches communicating with the outside and connectable to a system for active perfusion of substances.

POWERED ORAL CARE IMPLEMENT INCLUDING A TRACKING MODULE AND TRACKING MODULE AND TRACKING MODULE THEREOF

Nº publicación: EP4725359A2 15/04/2026

Solicitante:

COLGATE PALMOLIVE CO [US]

Resumen de: EP4725359A2

0001 An oral care system that includes an oral care implement and a tracking attachment. The oral care implement may include a handle and a head. The tracking attachment is detachably coupled to the oral care implement. The tracking attachment may include a first component comprising a first housing having an inner surface that defines a first cavity and a second component comprising a second housing having an inner surface that defines a second cavity. When the tracking attachment is coupled to the oral care implement, a first portion of the handle is positioned within the first cavity and a second portion of the handle is positioned within the second cavity.