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充填レベル判定システムの解放基準を決定する検出装置

Resumen de: CN121511392A

A detection device for determining a release criterion for a fill level determination system (1), the fill level determination system determining a fill level of a medical fluid in a container (300), the detection device comprising: a position detector (113) configured to determine a position of the fill level determination system (1); an acceleration detector (113) configured to determine an acceleration of the fill level determination system (1), where if the determined position lies within a tolerance range around the reference position and if the acceleration lies within the tolerance range, a fill level measurement of the fill level determination system (1) is recorded as a rationality measurement, and if the determined position lies within the tolerance range. And granting a release criterion on the basis of the rationality measurement if the fill level measurement of the fill level determination system (1) does not exhibit an excessive change compared to the previous fill level measurement.

呼吸療法を調整するための方法及び装置

Resumen de: AU2024278840A1

Systems and methods provide for monitoring treatment of respiratory disorder(s) by a therapy apparatus (4000) A pressure device may deliver pressurised air to a patient interface that is, in use, connected to a patient. Sensor(s) may monitor characteristic(s) of the pressurised air. Processor(s) may control the pressure device to deliver the air at treatment pressures responsive to adverse events. The delivered treatment pressures may be maintained within a range of treatment pressures between a minimum therapeutic pressure and a maximum therapeutic pressure. Adverse events may be detected based on the monitored characteristic(s)of the air during treatment session(s). Counts of the detected adverse events that occur during pressure delivery within a given range of treatment pressures for the treatment sessions may be evaluated. A recommendation or automated operation may be generated that includes a parameter change for use in a subsequent therapy session in response to the counts of detected adverse events.

SYSTEMS, DEVICES, AND METHODS FOR FLUORESCENCE IMAGING WITH IMAGING PARAMETER MODULATION

Resumen de: EP4779295A2

Systems, devices, and methods provide for the operation of a portable, hand-held device comprising an illumination device including at least one excitation light source and a driver configured to drive the at least one excitation light source to sequentially produce a plurality of output intensities; an imaging device configured to capture a plurality of fluorescence images of a target surface respectively corresponding to the plurality of output intensities; a memory; and a processor configured to: co-register the plurality of fluorescence images, divide an image area into a plurality of sections, for each of the plurality of sections, select an image portion from one of the plurality of fluorescence images, and combine the selected image portions to generate a composite image.

ADAPTIVE DECISION SUPPORT SYSTEMS

Resumen de: EP4778459A2

0001 Certain aspects of the present disclosure relate to a method of configuring an application with one or more application features. The method comprises receiving a request to configure the application for use by a user. The method further comprises identifying an objective for the user and identifying classifying information associated with the user, the classifying information including at least one of the objective, interest, ability, demographic information, disease progression information, or medication regimen information of the user. The method further comprises selecting a group of users based on one or more similarities between the user and the group of users. The method further comprises identifying the one or more application features based on the objective of the user and a correlation of each of the plurality of application features with the objective. The method further comprises configuring the application with the one or more application features.

SOFT TISSUE RECOSTRUCTION IMPLANTS AND FORMING METHOD THEREFOR

Resumen de: EP4778543A2

Embodiments herein relate to an implant for insertion into a patient. The implant comprises a plurality of unit cells arranged to form a three-dimensional lattice structure, the three-dimensional structure comprising a resting volume of the implant. The plurality of unit cells are arranged to form a porous network of the three-dimensional structure, and wherein the three-dimensional structure is a reversibly compressible three-dimensional structure, wherein a bulk porosity of the three-dimensional structure (101) of the implant is at least 50 %.

歯修復用歯科装具の自動作成

Resumen de: WO2020240351A1

Techniques are described for automating the design and manufacture a dental restoration appliance for restoring the dental anatomy of a patient. For example, a system processes a digital three-dimensional (3D) model of a future (desired) dental anatomy of a patient, the future dental anatomy representing an intended shape of at least one tooth of the patient. The system includes a landmark identifier configured to automatically compute, based on the digital 3D model of the future dental anatomy of the patient, one or more landmarks of the future dental anatomy of the patient. The system also includes a custom feature generator configured to automatically generate, based on the one or more landmarks, one or more custom appliance features for a dental appliance for restoring the at least one tooth of the patient. The system further includes a memory device configured to store a digital model of the dental appliance.

IMPROVED WORK STATION FOR MEDICAL DOSE PREPARATION SYSTEM

Resumen de: EP4779579A2

0001 The claimed invention relates to a work station for medical dose preparation management, the work station comprising: a base including a scale; a medication preparation staging region; a housing; a support engaged with the housing and the base; an imaging device having an imaging field encompassing at least a portion of the medication preparation staging region, the imaging device being located at least partially within the housing; at least one light source disposed in the housing, wherein the at least one light source is operable to emit light from the housing in a direction toward the medication preparation staging region; a memory; and a processor in operative communication with the memory, wherein the work station further comprises a display in operative communication with the processor.

PROSTHETIC ELEMENT AND RELATIVE METHOD TO MAKE IT

Resumen de: EP4778727A2

Prosthetic element comprising a cap (11) made of metal material. At least part of said cap (11) consists of a lattice (12) that makes a plurality of open and intercommunicating cavities (18).

一种基于拉伸诱导的单细胞尺度载细胞生物纤维3D打印方法

Resumen de: CN122424420A

本发明涉及一种基于拉伸诱导的单细胞尺度载细胞生物纤维3D打印方法，属于组织工程技术领域。该方法通过拉伸诱导生物3D打印技术将活体细胞载入多种类型的可拉伸型活性生物墨水中，通过生物拉伸诱导打印策略，利用快速交联固化技术构建单细胞尺度载细胞纤维，经进一步结构设计打印成具有特定拓扑结构的单细胞层面微细生物组织/器官。这些微细纤维能够模拟天然细胞外基质的网络结构，为细胞提供适宜的生长环境，实现人工组织/器官构建，从而实现组织的修复和再生。

结合外泌体制剂浸润的膨体鼻成型假体设计与优化方法

Resumen de: CN122423995A

本发明属于医用高分子与组织修复材料技术领域，具体涉及结合外泌体制剂浸润的膨体鼻成型假体设计与优化方法。先采用三维建模和多喷头高精度3D打印技术制备膨体鼻成型假体；对制备的膨体鼻成型假体进行等离子体表面处理；收集脂肪干细胞培养上清液并进行离心分级和超速离心处理，得到外泌体制剂；使用外泌体制剂对膨体鼻成型假体进行浸润处理；浸润完成后对膨体鼻成型假体进行干燥处理；对获得的经外泌体制剂浸润处理的膨体鼻成型假体进行性能检测，检测结果通过反馈修正膨体鼻成型假体参数。本发明的方法通过调控膨体假体的微孔结构参数及外泌体制剂浸润条件，提高假体的亲水性与生物相容性，提升假体结构的稳定性和抗变形性能。

一种全流程数字化义齿智能制造生产方法及系统

Resumen de: CN122423980A

本发明涉及义齿智能制造技术领域，公开了一种全流程数字化义齿智能制造生产方法及系统，生产方法包括多模态口腔数据采集、数据传输和预处理、AI识别并初步设计、智能工艺规划并自动化制造、自动化后处理与个性化优化以及成品检测并追溯六个步骤，本发明相较于传统义齿生产，将生产步骤缩减到六个步骤，即可完成成品交付，缩短生产周期，减少生产工序，同时利用AI等算法辅助减少对人工的依赖程度，提高生产效率，提升成品的合格率，以解决目前行业中存在的义齿制作周期长、工序繁琐的缺陷。

一种3D打印制备GO/BG/BMP-2复合支架的方法及其应用

Resumen de: CN122424428A

本发明涉及生物医用材料技术领域，尤其涉及一种3D打印制备GO/BG/BMP‑2复合支架的方法及其应用。本发明通过以聚己内酯（PCL）为基底，掺杂合理比例的GO（氧化石墨烯）与BG（生物活性玻璃）通过3D打印制备出多孔初始支架，并通过EDC/NHS化学偶联负载BMP‑2（骨形态发生蛋白‑2）最终制备出具有网状结构的复合支架，该复合支架兼具良好的力学性能、生物相容性与高效成骨活性，不仅能够为骨缺损修复提供物理支撑和化学刺激，更能动态调控局部生物微环境（如炎症‑成骨转换），其能够通过调控EGFR、TNF‑α、RUNX2、BMP‑2等核心靶点及相关信号通路高效促进骨缺损修复。

Medicament delivery device

Resumen de: USRE50960E

0000 The present invention relates to a medicament delivery device comprising a housing (60), which housing is arranged to accommodate a medicament container (62); a drive unit (86) operably arranged to act on said medicament container (62) for expelling a dose of medicament; an activation unit (74) operably connected to said drive unit for activating said drive unit (86); said drive unit (86) comprising an actuation element (84) arranged movable inside the housing (60) from an initial position prior to activation, to a displaced position after activation; at least a first NFC-chip (170, 172) comprising specific information arranged on said actuation element; at least one shielding element (174) arranged to said housing, such as to shield said at least first NFC-chip (170, 172) from being read by an NFC-chip reader when said actuation element (84) is either in the initial position or in the displaced position. The present invention also comprises a communication system in which said medicament delivery device is a part.

椎间融合器及其制备方法

Resumen de: CN122424408A

本发明公开了一种椎间融合器及其制备方法。该制备方法包括：（1）将聚己内酯和生物活性磷酸三钙微球混合均匀，按照预设的数字模型打印获得外周骨架，所述外周骨架围合形成有空腔；（2）将胶原蛋白溶液、生物活性磷酸三钙微球和化学交联剂混合均匀得到混合浆料，灌注到所述外周骨架中，其中所述外周骨架本身的孔隙以及围合形成的所述空腔被所述混合浆料填充；再冷冻干燥，获得初步成型的椎间融合器；（3）将初步成型的椎间融合器浸入化学交联剂中，进行第二次化学交联，再冷冻干燥，得到最终产品。本发明的椎间融合器具有优异成骨活性、一体化成型且操作便捷。

一种具有3D打印条纹织构的医用金属植入物的制造方法和医用金属植入物及其用途

Resumen de: CN122425218A

本发明提供一种具有3D打印条纹织构的医用金属植入物的制造方法和医用金属植入物及其用途。所述制备方法包括以下步骤：S1：根据患者骨缺损位置解剖形态建立定制化骨植入物的三维模型；S2：定制骨植入物的金属组成和结构设计，其中，所述结构设计包括表面条纹织构间距，所述表面条纹间距为50~500μm；S3：对骨植入物的三维模型进行截面剖分并基于骨植入物的结构设计确定激光粉末床熔融打印机的激光扫描间距和层间扫描旋转角，其中，所述激光扫描间距为100~400μm，所述层间扫描旋转角为0或60°；S4：基于打印数据通过逐层送粉、激光扫描熔融的方式打印成型，得到一体化的具有3D打印条纹织构的医用金属植入物。

Systems and methods for measuring, quantifying, displaying and otherwise handling/reporting health status data and risks via self-directed health screening, information, and processing information regarding associated professional advice

Resumen de: US12685447B1

Self-directed health screening systems and methods utilizing user navigation and device integration, health analyzing algorithms, and/or self-learning techniques for the detection, quantifying, prevention, and management of health risks and discoverable health conditions. Implementations herein may include components or involve aspects associated with information collection, information processing, display/provision/rendering of professional advice, and/or processing of various associated data and information via network(s). Implementations herein provide for innovatively configured, easily upgradable, efficient, portable, scalable, easy-to-use, usage-encouraging, and/or effective implementations for screening, predicting points of inflection of pending health issues, preventing and/or managing users' health, provided via various and multiple embodiments having numerous advantages over other known techniques. Screenings, health information, and user-selectable choices may be optimized for each unit by offering different combinations over a period of time and iterating to produce the greatest usage and user traffic thereby best serving the specific health needs of the user base and sponsoring advertisers.

颌功能为导向骨水泥间置物数字化导板及制作方法

Resumen de: CN122423935A

本发明涉及口腔颌面外科颌骨缺损修复技术领域，具体公开了颌功能为导向骨水泥间置物数字化导板的设计及制作方法，其中导板包括一期协同导板组与骨松质定量填充导板；所述一期协同导板组由截骨导板、间隙维持导板、骨水泥间置物塑形导板组合构成，所述截骨导板、间隙维持导板、骨水泥间置物塑形导板对应位置开设有相互对齐且贯穿下颌骨布设的同一组固定孔洞，形成可互换装配的共用定位结构；所述骨松质定量填充导板为三面封闭、一面开放的U形槽体结构，所述骨松质定量填充导板的内腔壁面与硬化后骨水泥间置物外形形成全包式限位贴合配合。本方案以统一定位配合结构、个性化塑形限位结构、定量填充约束结构形成结构联动，提高了下颌骨缺损整体修复精度。

基于光学体表数据重建高精度三维模型的补偿膜制备方法

Resumen de: CN122399265A

0001 本发明公开了基于光学体表数据重建高精度三维模型的补偿膜制备方法，涉及乳腺癌术后放射治疗技术领域，包括：依次进行的体表数据采集、高精度模型重建、补偿膜优化设计、3D打印制备、CT定位扫描及放疗计划优化，通过光学体表监测系统采集患者相关区域三维数据，经特征筛选与重构生成高精度体表模型。该方法无需额外电离辐射，有效解决传统补偿膜贴合度差、现有光学扫描数据质量不足的问题，通过全流程个性化优化与精准制备，提升补偿膜与体表贴合精度及放疗剂量准确性，适用于乳腺癌术后放射治疗，具有临床适用性强、安全高效的特点。

产生解剖结构的仿制品的方法和系统

Resumen de: EP3703014A1

0001 Creating a replica of an anatomical structure. At least some of the example embodiments are methods including: accepting a plurality of pictures of the anatomical structure of a subject; creating an object file that contains an initial model of an outside surface of the anatomical structure; cutting the initial model to a predetermined exterior shape circumscribing the anatomical structure, the cutting creates a positive model of the anatomical structure within the predetermined exterior shape; creating a negative model of the anatomical structure from the positive model; placing a stem tool object on an outside surface of the negative model in relationship to an orifice of the anatomical structure, and thereby creating a final negative model; printing, by way of a three-dimensional printer, the final negative model to create a negative mold; and casting the replica of the anatomical structure using the negative mold.

自操作快拆装组件用于单颗牙移动的装置及制备方法

Resumen de: CN122398486A

本发明提供自操作快拆装组件用于单颗牙移动的装置及制备方法，属于口腔正畸矫治领域。包括：快拆装组件和弓丝；快拆装组件包括目标牙快拆装件和支抗牙快拆装件；目标牙快拆装件固定于目标牙，其表面设有便于弓丝滑入的弧形表面并设有引导通道，引导通道包括连接成一体的引导区和固位区，引导区为弧形路径，固位区用于限制弓丝工作位置；支抗牙快拆装件固定于目标牙一/两侧，包括中央连接部以及翼片结构，翼片与中央连接部之间形成卡槽；弓丝一/两端设有与卡槽配合的快拆装环，弓丝末端/中部挂入目标牙快拆装件引导通道并产生弹性形变形成矫治力。实现了矫治装置的患者自操作，提高了单颗牙移动矫治效率，降低了治疗成本与医患负担。

硬脑膜内侧个性化电极设计方法、系统、介质及制造方法

Resumen de: CN122417438A

本发明涉及医学影像处理技术领域，提供了硬脑膜内侧个性化电极设计方法、系统、介质及制造方法，包括：获取目标用户硬脑膜内侧表面的三维模型；根据目标需求在三维模型上确定包含目标功能区的基底形态区域，且基底形态区域利用硬脑膜内侧表面的凹陷路径实现力学锚定；基于基底形态区域对应的二维平面，依据功能热力图优化电极触点的空间分布以确定触点布局；根据基底形态区域和电极触点布局生成电极设计文件。本发明实现了电极与个体解剖结构的精确共形贴合与长期稳定锚定，提升了信号采集效率。

基于XR的空间疗愈系统及其提供方法

Resumen de: CN122417309A

0001 本发明涉及一种基于XR的空间疗愈系统及其提供方法。该系统包括：追踪部，用于追踪用户的实时位置及视线信息；传感器部，用于测量用户的生物信号；音频输出部，通过调节虚拟声源方向性的三维空间音效渲染技术来输出引导音响；以及控制部，根据基于生物信号的心理状态来控制空间引导音响以及包含可听和非听觉愈疗音频通道的控制。本系统全面应用了包含基于机器学习的生物信号分析、基于深度学习的视觉识别、基于强化学习的参数优化以及基于联邦学习的隐私保护在内的人工智能技术，从而提供针对用户个人优化的自适应空间疗愈。

基于小胶质细胞活化定量成像的毒性风险评估系统

Resumen de: CN122398197A

0001 本申请提供了一种基于小胶质细胞活化定量成像的毒性风险评估系统。包括：获取待测化疗患者的化疗相关中枢神经毒性易损脑区的小胶质细胞活化定量数据，所述小胶质细胞活化定量数据通过小胶质细胞与巨噬细胞特异性分子探针的正电子发射断层扫描成像获得，用于定量表征对应脑区的小胶质细胞活化密度与代谢水平；获取待测化疗患者的血清轴突损伤标志物的定量检测数据，作为神经结构损伤的验证指标；以小胶质细胞活化定量数据为核心权重，结合轴突损伤标志物检测数据，计算生成化疗相关中枢神经毒性风险指数，基于所述化疗相关中枢神经毒性风险指数划分风险等级，明确风险驱动因素，输出匹配风险等级的干预决策提示。

一种具有用药依从性预测与干预的管理方法及系统

Resumen de: CN122417275A

本发明涉及一种具有用药依从性预测与干预的管理方法及系统，包括：S1、用户通过手机APP扫描药品包装二维码或手动输入药品信息；S2、微型压力传感器实时采集各药格重量数据，RFID芯片读写器定期校验药品信息，控制模块的数据处理单元通过数据融合算法判定有效服药、过量取用、漏服及药品过期状态，记录正常服药数据或异常事件；S3、到达预设服药时间启动一级提醒；S4、控制模块的算法运行单元基于过去90天用药数据，生成用户个性化依从性数据；当识别到停药倾向时，提前24小时发送“个性化提醒礼包”，家庭医生通过终端实时查看用药情况并可远程调整用药方案；家属端APP同步接收用药提醒，能够代为完成服药确认操作。

个性化托槽粘接底板的数字化生成方法

Nº publicación: CN122398484A 17/07/2026

Solicitante:

京通奥瑟医疗科技（北京）有限公司

Resumen de: CN122398484A

本发明公开了一种个性化托槽粘接底板的数字化生成方法，属于口腔正畸医疗器械数字化制造技术领域。本发明通过获取患者牙列三维数字化模型，拟合生成与牙面形态适配、厚度0.10–1.00mm的个性化底板；根据底板厚度在非粘接面保留0.05–0.95mm结构壁厚，在其余区域参数化生成蜂窝、多边形、圆形或不规则固位单元，并在固位单元侧壁开设镂空交通孔，使相邻单元相互连通；在底板与托槽主体结合区域将固位单元加深延伸并伸入托槽内部，在加深段设置多层交通孔，形成立体贯通式粘接通道；最终经数字化仿真优化与3D打印实现一体化成型。本发明实现了固位结构、交通孔、深嵌固位区域的参数化精准生成，显著提高粘接强度与密实度，减少气泡，保证结构强度与成型可靠性，可适配舌侧/唇侧个性化托槽及多种生物材料，解决传统底板固位不足、易脱落、数字化生成精度低等问题，具有高效稳定、适于规模化生产的工业实用性。