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自供能生物3D打印生物墨水、3D打印生物活性支架及其制备方法

Resumen de: CN120827636A

本申请提供的自供能生物3D打印生物墨水、3D打印生物活性支架及其制备方法，本发明是通过在不同分子量的有机高分子聚合物与促能量代谢物质混合制备得到可控释放的自供能生物3D打印生物墨水，该墨水生物相容性好，可通过改变供能物质含量，可以被设计成以可调和时间的方式“提供”和“接受”不同的细胞代谢调节线索，实现细胞更好的迁移和黏附，并发挥功能，同时该墨水在通过3D打印构建三维支架，具有可控缓释促能量代谢物质并生成微纳孔隙，提高支架亲水性，增强复合材料的生物能量代谢活性，促能量代谢物质可以为细胞生长提供足够的营养环境，调控细胞能量代谢过程，有利于细胞的粘附、生长与增殖及功能化。

METHOD AND SYSTEM OF CREATING A REPLICA OF AN ANATOMICAL STRUCTURE

Resumen de: MX2024003829A

Creating a replica of an anatomical structure. In one embodiments a method includes: accepting pictures of the anatomical structure of a subject; creating an object file that contains an initial model of an outside surface of the anatomical structure; cutting the initial model to a predetermined exterior shape circumscribing the anatomical structure to create a positive model; creating a negative model from the positive model; placing a stem tool object on an outside surface of the negative model in relationship to an orifice, thereby creating a final negative model; placing a zeroing and angling object to align the negative model to a predetermined angle; placing a base tool object by coupling the base tool object to the outside surface; printing, by way of a three-dimensional printer, the final negative model to create a negative mold; and casting the replica of the anatomical structure using the negative mold.

OPTICAL MICROSCOPE APPARATUS FOR HIGH-RESOLUTION LOCAL SPECTRUM ANALYSIS

Resumen de: KR20250153100A

본 발명의 일실시예에 따른 중공형 마이크로니들의 제조 방법은, 제조하고자 하는 중공형 마이크로니들에 대응하는 형상의 캐비티가 구비된 PDMS 몰드를 제조하는 단계, 상기 중공형 마이크로니들의 중공홀에 대응하는 형상의 스트링 구조물이 구비된 스트링 구조물 몰드를 제조하는 단계, 상기 스트링 구조물 몰드와 상기 PDMS 몰드를 결합하는 단계, 상기 스트링 구조물 몰드와 상기 PDMS 몰드의 사이에 레진을 주입 및 경화시켜 상기 중공형 마이크로니들을 형성하는 단계, 및 상기 PDMS 몰드를 제거한 후 상기 스트링 구조물 몰드를 용해액으로 녹여 상기 중공형 마이크로니들을 획득하는 단계를 포함한다.

一种3D打印紫外光交联田菁胶水凝胶支架及制备方法和应用

Resumen de: CN120827641A

本发明为一种3D打印紫外光交联田菁胶水凝胶支架及制备方法和应用，所述田菁胶水凝胶为甲基丙烯酸酯化田菁胶水凝胶。所述制备方法包括以下步骤：甲基丙烯酸酐改性田菁胶水凝胶原料，经透析、冻干，获得甲基丙烯酸酯化田菁胶粉末；接着用含光引发剂的PBS进行溶解得到水凝胶；将所得水凝胶与干细胞复合，经过生物3D打印机打印后进行紫外光交联，即得所述田菁胶水凝胶支架产物。所述支架复合经软骨诱导液诱导的干细胞，有潜力应用于软骨修复工程。本发明具有生物相容性好、安全性强、材料性能可控、成本低、来源广、操作简单等优点。

3D 3D PRINTED ELECTRONIC DEVICE USING HYDROGEL AND ITS MANUFACTURING METHOD

Resumen de: KR20250152704A

본 발명은　하이드로겔을 이용한 3D 프린팅 전자소자 및 그 제조방법에 관한 것이다. 일 실시예에 따르면, 전도성 하이드로겔로 이루어진 제1 하이드로겔층; 및 상기 제1 하이드로겔층 하부에 배치되되, 피부 접착성 하이드로겔로 이루어진 제2 하이드로겔층;을 포함하는, 하이드로겔을 이용한 3D 프린팅 전자소자가 제공될 수 있다.

CUSTOM SEGMENTED INDIRECT BOND TRAYS

Resumen de: WO2025222183A1

Some embodiments relate to techniques of designing indirect bonding (IDB) trays that compensate for factors that affect the bonding success of orthodontic appliance(s) using IDB trays. The techniques apply optimization rules to an IDB tray design to optimize the transfer accuracy of orthodontic appliance(s) to a patient's teeth using IDB tray(s) of the IDB tray design. For example, the techniques may compensate for movement of teeth relative to an initial scan, narrow/wide central arches, teeth planned for extraction, and/or other factors. The techniques may, for example, customize segmentation of IDB trays in an IDB tray design to compensate for factors that affect bonding success.

COMPONENTS AND METHODS FOR MAKING SCAFFOLD TISSUES VIA PECTIN-CONTAINING SACRIFICIAL TEMPLATES

Resumen de: WO2025222151A1

Disclosed herein are aspects of a scaffold for tissue regeneration, the scaffold comprising a first component comprising one or more biocompatible materials; and a second component comprising a pectin-containing sacrificial template, wherein the second component is intermittently associated with the first component. In certain aspects, the scaffold may further comprise a disassociating agent for dissolving the second component. Also, disclosed herein is a method for making a scaffold for tissue regeneration, the method comprising providing a first feed to a first nozzle and a second feed to a second nozzle, the first feed comprising one or more biocompatible materials, the second feed comprising pectin, pectin derivatives, or a combination thereof; and obtaining a composition comprising a first component and a second component, the first component comprising the one or more biocompatible materials, and the second component comprising a pectin-containing sacrificial template that is intermittently associated with the first component.

METHOD AND APPARATUS FOR PRODUCING A MESOSTRUCTURAL ELEMENT AND METHOD FOR DENTAL RESTORATION IN AN ORAL CAVITY

Resumen de: WO2025219028A1

Method and apparatus for producing a mesostructural element and method for dental restoration in an oral cavity The invention relates to a method for producing a mesostructural element (3), the mesostructural element (3) being adapted to be fixed to at least one oral implant and to carry at least one suprastructure for prosthetic replacement of a plurality of teeth in an oral cavity, the method comprising: ˗ arranging at least one implant proxy element (17) at a predetermined position in a jawbone model (7), ˗ attaching at least one preform element (19) to the at least one implant proxy element (17), ˗ forming the mesostructural element (3) onto the at least one preform element (19) by laser metal deposition, wherein ˗ the jawbone model (7) and a LMD nozzle (11) are positioned relative to each other by a positioning apparatus (13) comprising at least four axes, and ˗ releasing the at least one preform element (19) from the at least one implant proxy element (17) and obtaining the mesostructural element (3).

ALGINATE MICROBEADS, METHODS FOR THEIR PREPARATION, AND BIOINK FORMULATIONS CONTAINING THE SAME.

Resumen de: WO2025219066A1

Provided are methods for preparing alginate microbeads that are particularly suitable as porogens for pore-forming hydrogel containing bioink formulations. Further provided are alginate microbeads obtainable by saidmethods, bioink formulations containing the same, and a method for producing a porous three-dimensional object using said bioink formulation.

POST-PROCESSING OF BIOLOGICAL SCAFFOLDS

Resumen de: AU2024238878A1

A method of modifying a surface of a three-dimensional (3D) article includes immersing at least one part of the 3D article in a buffered solution of functionalized peptides, allowing reaction between the functionalized peptides and reactive groups on the surface of the 3D article; and washing the at least one part of the 3D article to remove unreacted functionalized peptides. The surface-modified 3D article includes a plurality of peptides covalently bonded to the surface of the 3D article via a cysteine bridge. The surface- modified 3D article can be used as a scaffold for the formation of biological tissue or bodily implants.

CUSTOM SEGMENTED INDIRECT BOND TRAYS

Resumen de: US2025325351A1

Some embodiments relate to techniques of designing indirect bonding (IDB) trays that compensate for factors that affect the bonding success of orthodontic appliance(s) using IDB trays. The techniques apply optimization rules to an IDB tray design to optimize the transfer accuracy of orthodontic appliance(s) to a patient's teeth using IDB tray(s) of the IDB tray design. For example, the techniques may compensate for movement of teeth relative to an initial scan, narrow/wide central arches, teeth planned for extraction, and/or other factors. The techniques may, for example, customize segmentation of IDB trays in an IDB tray design to compensate for factors that affect bonding success.

BONE FASTENER WITH A DIVERGING CANNULATION

Resumen de: US2025325314A1

A cannulated bone fastener (10) for engagement into a target bone and/or target bone fragment is provided. According to one embodiment. the cannulated bone fastener (10) comprises an elongated shaft (11) extending between a bone fastener tip or tip section and a bone fastener head or head section. a central cannulation (17) having a cannulation entry with a first cross-sectional area (A1) at the shaft tip section, and a cannulation exit with a second cross-sectional area (A2) at the head section, and wherein the first cross-sectional area (A1) is different from the second cross-sectional area (A2), and wherein the surface roughness of the cannulation wall is at most 25 micrometres.

SURGICAL GUIDES WITH REMOVABLE INSERTS

Resumen de: US2025325284A1

The present disclosure describes a surgical guide comprising a cutting guide defining a plurality of cutting slots and including at least one removable insert positioned between the plurality of cutting slots. The at least one removable insert defines an aperture which is designed to receive a surgical fastening device. The surgical guide further comprises a template guide which defines a feature. The at least one removable insert is designed to fit in the template guide at least in part using the feature.

3D PRINTING MOUTH PIECE INCLUDING SIMULATION OF DEFORMATION

Resumen de: US2025325353A1

A method for manufacturing a mouth piece, in particular by jetting droplets of a first droplet material and a second droplet material in a 3D printing process. The method comprises a step of obtaining dental data of a user and an input mouth piece model. A simulation is carried out to determine a deformation of the input mouth piece model in response to an exerted force. Based on the deformation, the input mouth piece model is adapted to a work mouth piece model by substituting material of at least a portion of the input mouthpiece model by a replacement material. Finally, the mouth piece is manufactured based on the optimised work mouth piece model.

POPULATION BASED EYEWEAR FITTING

Resumen de: US2025328030A1

Certain aspects provide a method for creating a discrete set of variants of a customizable wearable object, comprising: receiving a baseline 3D design file for a baseline 3D customizable wearable object; obtaining a fitting population comprising a set of 3D anatomy models representing potential wearers of the customizable wearable object; generating a plurality of modified 3D customizable wearable objects based on fitting the baseline 3D customizable wearable object to each 3D anatomy model of the set of 3D anatomy models; selecting one or more of the plurality of modified 3D customizable wearable objects as the discrete set of variants of the customizable wearable object; and generating a set of 3D design files corresponding to the discrete set of variants of the customizable wearable object.

FINISHED PHARMACEUTICAL FORM WITH INDIVIDUAL MEDICINE DOSING CAPABILITY (EMBODIMENTS) AND METHODS OF ITS PRODUCTION AND USE

Resumen de: US2025325451A1

According to some embodiments, a method and system are provided comprising receiving a first quantity of at least one medicine in at least one cartridge of a plurality of cartridges of a printing device; receiving a porous media in the printing device; dispensing a first drop of the at least one medicine onto the porous media; and drying the dispensed drop on the porous media. Numerous other aspects are provided.

Breakaway Covers for Use in Processing Build Structures With Porous Regions

Resumen de: US2025326036A1

An in-process build structure includes a first build structure portion, a second build structure portion, and a cover. The second build structure portion is attached to the first build structure portion and defined by a plurality of porous portion struts. The cover at least partially overlies the second build structure portion and is attached to a remainder of the build structure by breakaway struts having breakaway strut diameters less than porous portion strut diameters of the porous portion struts. The in-process build structure is subjected to a surface treatment while the cover is attached to a remainder of the in-process build structure. The cover is removed from the remainder of the in-process build structure after the surface treatment.

GRIPPING SURFACE FOR MANUFACTURED ARTICLES

Resumen de: US2025326137A1

A gripping surface for a manufactured article comprising: a first pillar cluster disposed on a substrate and having: a first pillar, having a first apex vector and a first draft angle defined by a first side of the first pillar and the substrate; a second draft angle defined by a second side of the first pillar and the substrate wherein the second draft angle is less than the first draft angle; and, a second pillar having a second apex vector wherein the first apex vector and the second apex vector are parallel; wherein the first pillar cluster has a triangular orientation; and, a second pillar cluster having: a first set of pillars arranged in a first concentric circle; and, a second set of pillars arranged in a second concentric circle wherein the first pillar cluster and the second pillar cluster cover less than 25% of the article.

HEAD ORTHOTIC WITH HINGE ASSEMBLY AND CLASP

Resumen de: US2025325385A1

A system for manufacturing a cranial remodeling orthosis (CRO) includes a scan device, a 3D printer, and processing circuitry. The scan device is configured to obtain scan data of a patient's head. The processing circuitry is configured to obtain the scan data of the patient's head. The processing circuitry is configured to use computer assisted design to generate a print file of the CRO based on the scan data, where the CRO includes at least one integrated closure mechanism. The 3D printer is configured to perform additive manufacturing to produce the CRO using the print file of the CRO.

SYSTEMS, METHODS, AND DEVICES FOR PLAQUE ANALYSIS, VESSEL AND FLUID FLOW ANALYSIS, AND/OR RISK DETERMINATION OR PREDICTION THEREOF

Resumen de: US2025329015A1

This disclosure relates to systems, methods, and devices for plaque analysis, vessel and fluid flow analysis, and/or risk determination or prediction thereof. Some embodiments relate to determining fractional flow reserve (FFR) values. Some embodiments relate to determining FFR values using 3D-printed models. Some embodiments relate to identifying thin cap fibroatheroma based on analysis of computed tomography (CT) imaging. Some embodiments relate adjusting calcified plaque thresholds for CT images to address effects of calcium blooming.

CRYSTALLIZABLE RESINS

Resumen de: US2025326927A1

This disclosure provides polymeric materials comprising polymer crystals, methods and resins for making the same, and objects and appliances made from said polymeric materials. Polymeric materials having polymer crystals provide favorable properties, such as enhanced durability and rigidity. This disclosure also provides polymeric materials comprising a crystalline phase comprising at least one polymer crystal, as well as an amorphous phase comprising at least one amorphous polymer. The crystalline phase can confer rigidity to the polymeric material, while the amorphous phase can confer elasticity and flexibility.

TRANSFER APPARATUS FOR ORTHODONTIC APPLIANCES AND RELATED METHODS OF MANUFACTURING

Resumen de: WO2024127105A1

Method of making a transfer apparatus includes providing a physical mockup having a shape that corresponds to a positive shape of a patient's dental arch and one or more orthodontic appliances connected to the arch via one or more sprues. A transfer apparatus may be formed over the physical mockup, with the transfer tray representing a negative replica of at least a portion of the mockup. The transfer apparatus may be used to seat the appliance on a patient's dental arch, after which point the appliance can be separated from transfer apparatus and bonded to the associated tooth.

DEVICE FOR MANUFACTURING BIOINK

Resumen de: EP4635526A1

A bio-ink manufacturing device according to the present disclosure is provided. The bio-ink manufacturing device include: a reaction vessel for performing a reaction on tissues of decellularized extracellular matrix and an ink solution; a bio-ink liquefy portion for stirring and compacting the tissues of decellularized extracellular matrix and liquefying the same into bio-ink; and a bio-ink discharge portion discharging the bio-ink whose liquefaction is completed to an outside of the reaction vessel.

METHOD AND APPARATUS FOR PRODUCING A MESOSTRUCTURAL ELEMENT AND METHOD FOR DENTAL RESTORATION IN AN ORAL CAVITY

Resumen de: EP4635447A1

The invention relates to a method for producing a mesostructural element (3), the mesostructural element (3) being adapted to be fixed to at least one oral implant and to carry at least one suprastructure for prosthetic replacement of a plurality of teeth in an oral cavity, the method comprising:- arranging at least one implant proxy element (17) at a predetermined position in a jawbone model (7),- attaching at least one preform element (19) to the at least one implant proxy element (17),- forming the mesostructural element (3) onto the at least one preform element (19) by laser metal deposition, wherein- the jawbone model (7) and a LMD nozzle (11) are positioned relative to each other by a positioning apparatus (13) comprising at least four axes, and- releasing the at least one preform element (19) from the at least one implant proxy element (17) and obtaining the mesostructural element (3).

OPHTHALMIC LENSES METHODS OF MANUFACTURING THE OPHTHALMIC LENSES AND METHODS OF DISPENSING EYE CARE PRODUCTS INCLUDING THE SAME

Nº publicación: KR20250152115A 22/10/2025

Solicitante:

사이트글래스비전인코포레이티드

Resumen de: TW202449426A

Ophthalmic lenses and method of manufacturing ophthalmic lenses are disclosed.