Alerta

BEHAVIOR-MODULATED PERSONALIZATION FOR ROBOTIC SURGERY

Resumen de: US20260207283A1

0000 A robotic surgical system is disclosed that integrates real-time surgeon behavior monitoring, biometric feedback, and adaptive AI-based decision support to enhance intraoperative performance and post-procedural analysis. The system includes a user behavior monitoring module to track surgeon interaction patterns, a biometric data aggregator collecting inputs such as heart rate variability, electrodermal activity, and eye tracking, and a feedback modulation engine operatively coupled to an AI inference engine. A phase classifier evaluates surgical criticality based on tool telemetry and contextual signals, enabling the system to dynamically escalate, suppress, or defer feedback. Surgeon-specific profiles guide system behavior across procedures, while a summary dashboard provides insights into feedback efficacy and surgeon responsiveness. The AI system continuously refines surgical guidance based on multimodal sensor data, surgeon preferences, and procedural outcomes, supporting personalized intraoperative adaptation and real-time risk mitigation. The invention enhances surgical safety, precision, and outcomes by leveraging intelligent automation and contextual surgeon state modeling.

SYSTEM AND METHOD FOR VARYING DATA VOLUME TRANSMITTED TO EXTERNAL SOURCE

Resumen de: US20260207867A1

A system and method for applying treatment and efficiently collecting monitoring data from a patient is disclosed. The system includes a respiratory therapy device having a transmitter and an air control device to provide respiratory therapy to a patient. The respiratory therapy device sends either low or high resolution data to the health analysis engine. The high resolution data is transmitted based on the occurrence of an event detected based on the low resolution data. The respiratory therapy device collects operational data and transmits the collected operational data. A health analysis engine is in communication with the respiratory therapy device. The health analysis engine receives the collected data to determine a health condition of the patient based on the collected data.

KNEE REPLACEMENT INSTRUMENTATION

Resumen de: WO2026154255A1

There is provided instruments for use during knee replacement surgery. Amongst other instruments, there is provided a clamp (100) for use in knee replacement surgery, the clamp (100) being operable to engage with a femoral sizing spoon (60) and a tibial resection guide (70) so as to enable positioning of the tibial resection guide (70) relative to a tibia (3) of a patient, the clamp (100) comprising an adjustment means configured to enable a thickness of a locking element (150) between a lower surface (154) and an upper surface (152) to be varied.

GENERATION OF INSTRUCTIONS FOR TREATMENT PLANNING

Resumen de: WO2026156092A1

A method includes obtaining treatment provider instructions associated with a target dental treatment. The instructions may be expressed in natural language. The method further includes providing first input including the instructions to an AI model. The method further includes obtaining output from the AI model including a first treatment protocol in association with the target dental treatment. The method further includes providing an alert to the treatment provider, the alert including the treatment protocol.

ORAL DEVICES WITH HYDROGELS FOR CAPTURE AND DETECTION OF DISEASE BIOMARKERS

Resumen de: WO2026155887A1

Systems and methods for detecting a disease biomarker in a subject are provided. In some embodiments, a system includes: an oral device configured to be positioned within a subject's mouth; a hydrogel carried by the oral device, where the hydrogel includes a polymer and a capture moiety coupled to the polymer, and where the capture moiety is configured to bind to a disease biomarker present in the subject's mouth; and a fluorescent moiety configured to label the disease biomarker bound by the capture moiety.

METHOD FOR PROVIDING A SPACER ATTACHMENT

Resumen de: WO2026153785A1

A method is disclosed for providing a spacer attachment for an intraoral sensing device, wherein the attachment is configured to define, during use, a spacing between a sensing component and an oral surface. The method comprises providing a sizing kit that includes one or more measuring components, operable by a user to acquire physical sizing information relating to the user's oral cavity. Subsequently, a spacer attachment is provided, with its size and/or shape being chosen based on the physical sizing information.

COMBINATION OF CULTURE MEDIUM COMPONENTS

Resumen de: WO2026155234A1

The present disclosure provides a culture medium for cell culturing, the culture medium containing a combination of specific components. The present disclosure provides a culture medium which contains a combination of components selected from the group consisting of: (1) a halcinonide component; (2) an ALK4/7 inhibitor or a TGFβ receptor type-1 kinase inhibitor; (3) a BRD7/9 double degradation factor or a BRD7/9 binding molecule (degradation factor); (4) an LATS1/2 inhibitor, a PKA inhibitor, or an AKT1 inhibitor; (5) a CK1/2 inhibitor, an insulin receptor inhibitor, a Tyr kinase inhibitor, a PKA inhibitor or a PKC inhibitor, or an adenosine kinase inhibitor; (6) an E-selectin inhibitor, a VCAM1 inhibitor, or an ICAM1 inhibitor; and (7) an LATS1 inhibitor + an LATS2 inhibitor.

COMPONENT FOR CULTURE MEDIUM

Resumen de: WO2026155233A1

Provided is a culture medium for culturing cells containing specific components. Provided is a culture medium comprising at least one component selected from a group consisting of (1) halcinonides, (2) ALK4/7 inhibitor or TGFβ receptor type 1 kinase inhibitor, (3) BRD7/9 dual degradation factor or BRD7/9 binding molecule (degradation factor), (4) LATS1/2 inhibitor, PKA inhibitor, or AKT1 inhibitor, (5) CK1/2 inhibitor, insulin receptor Tyr kinase inhibitor, PKA inhibitor, or PKC inhibitor or adenosine kinase inhibitor, (6) E-selectin inhibitor, VCAM1 inhibitor, or ICAM1 inhibitor, and (7) LATS1 inhibitor + LATS2 inhibitor.

AUTOMATED INSULIN DELIVERY DEVICE AND METHODS ASSOCIATED THEREOF

Resumen de: WO2026154477A1

The present disclosure is directed to embodiments for an automated insulin delivery (AID) device which includes, inter alia, a housing including an adhesive tape configured, to adhere the housing to the skin of a user via. an adhesive tape. The housing houses at least an insulin pump including a single lumen cannula, a glucose sensor including a sensor probe, a processor, an insertion assembly for inserting the single lumen cannula, and the sensor probe within subcutaneous tissue, and an automated-insulin-delivery algorithm (AIDA). The sensor probe at least partially resides within the single lumen cannula, and the AIDA is configured as computer instructions operating on the processor causing the processor to automatically control insulin delivery by the insulin pump according to glucose levels from subcutaneous tissue based on signals received from the glucose sensor.

INSTRUMENT FOR OPHTHALMIC SURGERY

Resumen de: US20260207379A1

0000 An instrument having a clamp with an active end and a sleeve (2) receiving the sliding clamp; a central body with a first proximal end integral with a handle and a second distal end to which is secured a first end of the clamp, opposite the active end; and an actuator formed by levers extending around the central body and having first ends connected to the central body and second ends joined by a bushing secured to the sleeve. The levers are elastically deformable between a first deactivated position of the clamp in which the active end of the clamp is open and protruding from the sleeve and a second activated position in which the sleeve exerts a force on the active end of the clamp by forcing the closure of the active end of the clamp. The central body, the actuator and the bushing (7) are a single piece.

DENTAL IMPLANTS WITH CORONAL FEATURES AND SYSTEMS, DEVICES, AND METHODS FOR DESIGNING AND MANUFACTURING SAME

Resumen de: US20260207306A1

Root-analog dental implants include one or more coronal grooves that are sized, shaped, and/or configured to correspond to a size, shape, and/or position of a bone crest for an extracted tooth a root-analog dental implant is designed and manufactured to replace. The coronal grooves may be configured to engage with bone of an alveolar socket to enhance engagement between the root-analog dental implant and the alveolar socket particularly for the time period following seating the root-analog dental implant within the socket site and prior to osseointegration of the root-analog dental implant with the alveolar socket. This promotes stability of the root-analog dental implant within the socket site immediately following insertion and thereafter, which may decrease movement of the root-analog dental implant within the socket site, decrease a likelihood of foreign material such as bacteria or food entering the socket site, and/or reduce a risk of implant failure and jawbone injury.

SINGLE SOURCE-DETECTOR SEPARATION APPROACH TO CALCULATE TISSUE OXYGEN SATURATION

Resumen de: US20260207091A1

0000 A tissue oxygen saturation (StO<2>) parameter is calculated using a single light source and single detector of an optical device, where the light source and detector are separated by a separation distance. A single source-detector separation (SSDS) approach to measure StO<2 >in the tissue of a subject utilizes only intensity measurements of three different wavelengths of light emitted from the same light source (or one or more wavelengths from adjacent one or more light sources) at the detector. In addition to the three intensity measurements, the other inputs to the calculation are a differential pathlength factor (DPF) and extinction coefficients for both oxy-hemoglobin and deoxy-hemoglobin for the given wavelengths. The StO<2 >parameter can be calculated for each distinct source-detector pair of an optical device.

SUPPLEMENT SYSTEM AND DEVICE

Resumen de: US20260207435A1

A system has a base member defining at least one chamber, and a cover cooperating with the base member to enclose the chamber. The cover includes at least one path associated with a respective chamber and positioned to be broken when the cover over the associated chamber is opened. A reader device has a housing sized to mate with a container enclosed by a cover, with the cover supporting a plurality of paths, with each path associated with and extending over each chamber. The reader device has first and second leads associated with a path of a respective chamber, and a controller configured to determine if a chamber is opened or unopened. A membrane for covering at least one chamber of a container is provided with a layer formed from an electrically non-conductive material, and a path formed from an electrically conductive material supported by the layer.

INSPECTION AND TESTING-BASED METHOD AND APPARATUS FOR VENTILATION DETECTION IN PATIENTS WITH MYASTHENIA

Resumen de: WO2026152711A1

The present invention relates to an inspection and testing-based apparatus for ventilation detection in patients with myasthenia. The apparatus comprises: a muscle strength monitoring module, which comprises an electromyographic sensor for collecting electromyographic signals and calculating a muscle strength index; a respiration monitoring module, which is connected to a mechanical ventilation device, and configured for acquiring respiration frequency, tidal volume, and inhalation time parameters of a patient; a blood detection module, which is configured for collecting a blood sample of the patient, and detecting a level of an inflammatory factor and a level of an anti-acetylcholine receptor antibody in blood; and a control module, which is configured for receiving muscle strength index data, respiration parameter change trend data, and blood detection data. When the muscle strength index is lower than a preset first threshold, a respiration parameter change trend is inconsistent with a preset mode, and when the level of the inflammatory factor or the level of the anti-acetylcholine receptor antibody in the blood is higher than a preset second threshold, it is determined that patient-ventilator asynchrony exists during ventilation.

A COMPUTER IMPLEMENTED METHOD AND AN APPARATUS FOR NON-INVASIVE AND EXTRA-CORPORALLY DETERMINING THE ARTERIAL CONCENTRATION OF A RADIOPHARMACEUTICAL, IN PARTICULAR A RADIOTRACER IN AN ORGAN OF AN ANIMAL AND/OR HUMAN BODY

Resumen de: US20260212963A1

0000 The present disclosure relates to a technique to non-invasively and extra-corporeally measure the arterial concentration of a radiotracer administered to animal and/or human bodies or subjects with a radiation detector. In particular a computer implemented method for non-invasive and extra-corporally determining the arterial concentration of a radiopharmaceutical, for example a radiotracer, in an organ of an animal and/or human body is proposed, the computer implemented method comprising the steps of: i) receiving, from the moment of administration of a certain amount of the radiopharmaceutical in the animal and/or human body, by one or more radiation sensors positioned near or on a measurement location of an organ electromagnetic radiation emitted by the radio-pharmaceutical over time; ii) converting the received electromagnetic radiation in a time-sequence of radiation signals; iii) generating one or more time-frequency representations of the radiation signals by time-frequency transformation, and iv) analyzing the time-frequency representations for determining the arterial concentration of the radiopharmaceutical.

測定された抵抗値に基づく医療画像の導電率の決定

Resumen de: WO2025003829A1

A method for generating at least one transducer location for delivering tumor treating fields to a subject is provided. The method includes obtaining a medical image of a subject, the medical image having a plurality of voxels, the medical image representing a plurality of tissue types of the subject, wherein at least one voxel is associated with each tissue type. The method further includes determining, using a trained machine learning model and the medical image of the subject, conductivities for the tissue types of the subject in the medical image, the trained machine learning model trained with medical images of a plurality of other subjects and resistances obtained from the application of tumor treating fields to the other subjects. The method further includes identifying a location of a tumor in the medical image and generating at least one transducer location for delivering tumor treating fields to the subject.

ULTRASOUND-EQUIPPED CATHETER STYLET SYSTEM

Resumen de: US20260207168A1

Apparatuses, methods, systems, and program products are disclosed for an ultrasound-equipped catheter stylet system. An apparatus includes a catheter and a stylet configured for insertion into the catheter. The stylet includes a shaft having a first end and a second end, an ultrasound transceiver coupled to the distal end of the shaft, the ultrasound transceiver configured to transmit and receive A-mode ultrasound signals along an axis of the shaft, and a position sensor coupled to the stylet and configured to generate position data corresponding to transmission and reception of the A-mode ultrasound signals, the position data indicating a spatial position of the distal end of the shaft relative to a reference point.

METHOD FOR DESIGNING AN ORTHODONTIC APPLIANCE THROUGH CORRECTION OF A SET-UP TOOTH MODEL

Resumen de: US20260207303A1

0000 A method for designing an orthodontic appliance using a computer comprises displaying a tooth arrangement image (S01), correcting an arrangement state of teeth in the tooth arrangement image (S02), correcting shapes of teeth in the tooth arrangement image (S03), displaying an orthodontic appliance on a screen according to the corrected tooth arrangement image (S04), and outputting the orthodontic appliance using a 3D printer (S05).

ACTIVATOR AND MANUFACTURING METHOD THEREFOR

Resumen de: WO2026152603A1

An activator, comprising an upper jaw portion (1) and a lower jaw portion (2). The upper jaw portion (1) and the lower jaw portion (2) are connected by means of a connecting portion (3). The upper jaw portion (1), the lower jaw portion (2), and the connecting portion (3) are integrally manufactured. The upper jaw portion (1) at least covers maxillary anterior teeth, and the lower jaw portion (2) at least covers mandibular anterior teeth. The manufacturing method for the activator is a 3D printing method.

PROCEDURE GUIDANCE FOR SAFETY

Resumen de: US20260207260A1

0000 Systems, devices, and methods for providing a computer-assisted endoscopic procedure guidance are disclosed. A procedure planning system can generate an endoscope navigation plan for a patient scheduled for an endoscopic procedure performed by an operating physician. The system comprises a processor that can access an endoscopic procedure database, identify therefrom physicians substantially matching the experience level of the operating physician, and retrieve reference procedure data of the past procedures performed by the matching physicians. The reference procedure data can be further selected from past procedures performed on patients with similar medical information to the scheduled patient. The processor can generate an endoscope navigation plan for the scheduled patient using reference procedure data. The endoscope navigation plan can be displayed along with the live endoscopic image to guide the operating physician in performing the procedure.

ELECTRONIC ILLUMINATOR FOR ILLUMINATING MEDICAL INFUSION LINES

Resumen de: US20260212986A1

0000 Aspects of an electronic illuminator for medical infusion lines is disclosed. The electronic illuminator comprising a rigid-flex printed circuit board and a light emitting diode and a lens directing light to a side scattering fiber optic cable. A power source supplies power to the circuit board and LED. An ambient light sensor on a flexible portion of the circuit board detects environmental light through a translucent ring. A microcontroller unit connected to the ambient light sensor adjusts the LED intensity based on detected ambient light, providing adaptive illumination for medical infusion lines.

KNEE TENSIONER WITH DIGITAL FORCE AND DISPLACEMENT SENSING

Resumen de: US20260207185A1

A tensioner tool for assessing joint laxity is disclosed. The tensioner tool comprises a pair of pivotally coupled arms, each arm comprising a proximal handle portion, a distal portion, and an insertion tip selectively coupled to the distal portion. The pair of arms pivot between a compressed configuration for insertion within the joint and an expanded configuration for distraction of the joint by applying a force to the handles, thus spreading the insertion tips. The tensioner tool also comprises a force sensor configured to measure the force applied to the handle portion and a positional sensor configured to measure a separation distance between the pair of arms. The tensioner tool also comprises a processor configured to calculate a distraction force at the insertion tips based on the measured force and to calculate a tip distance between the insertion tips based on the measured separation distance.

SYSTEMS AND METHODS FOR ASSESSING SOCIAL SKILLS IN VIRTUAL REALITY

Resumen de: US20260212774A1

0000 Systems and methods provided in this disclosure explain the use of interactive narratives in VR to derive performance metrics for the assessment of individuals'socio-emotional skills. It also provides an explanation of how the change of narrative flow can be configured according to user responses, and how this changing nature of narratives can be used for more valid socio-emotional skills assessment for better prediction of real-life performance in targeted domains.

Beam Filtration Apparatus and Method for Efficient Scanned Beam Particle Arc Therapy

Resumen de: US20260207971A1

0000 A filter for radiation therapy, and other applications, is disclosed. The filter comprises a base and columns of varying heights extending from one face of the base. The column heights are determined by simulating the change in energy distribution of radiation passing through the filter and updating the column heights so as to more accurately match the desired output beam energy distribution. The method of filter design employs an inner loop of faster, but less accurate calculations and an outer loop of slower but more accurate calculations. The column heights for the filter are the last calculated values or the ones which produce the simulated output beam energy distribution which most closely matches the desired output beam energy distribution. The filter can be used in a radiation beam apparatus to treat a patient more quickly.

MODULAR SYSTEM AND UNDERWATER 3D BIOPRINTER COMPRISING SUCH MODULAR SYSTEM

Nº publicación: US20260208440A1 23/07/2026

Solicitante:

BIOPRINT3RS S R L [IT]
BIOPRINT3RS S.R.L.

Resumen de: US20260208440A1

0000 A modular system (1) insertable into a confined environment (20), such as, for example, a tank containing a fluid, including: a base unit (2) comprising a work surface (3) that is movable along a working plane; an upright structure (9) constrained to one side of the base unit (2) and extending away therefrom; a support head (10) for supporting a tool or an accessory; said upright structure (9) comprising in turn: a guide means (11) for guiding the support head (10) along a direction (Z) transversal to the working plane; a sliding means (14) for sliding the support head (10) along the guide means (11); at least one motor (M) for the sliding means (14); a box-like casing (15) provided with sealing gaskets for housing said motor (M), said modular system (1) further comprising at least one tubular body (21) for cables of the motor (M).