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BIOINK COMPOSITIONS COMPRISING THERMOSENSITIVE MICROPARTICLES AND USE THEREOF

Resumen de: WO2025191563A1

The present invention is directed to a method for 3D printing of cells attached to a cell scaffold by simultaneous printing of a first composition comprising thermoresponsive microparticles and a second composition comprising cells. Further provided a printed 3D object such as an implant, comprising cells attached to the cell scaffold of the invention.

SACROPELVIC FUSION IMPLANT SYSTEM FOR PROVIDING A FOUNDATION FOR SPINOPELVIC FIXATION CONSTRUCTS IN ADULT SPINAL DEFORMITY SURGERY

Resumen de: US2025288424A1

A method of surgically treating a patient suffering from severe pain and disability of the low back and buttock by stabilizing the patient's spinal column to their pelvis with an implant system including surgical tools and an implant designed to prevent movement between the sacrum and the ilium while being able to attach to a spinal fusion rod which connect to pedicle screws implanted in the bones of the spine of the patient in order to offer lasting relief of the patient's symptoms. The system is designed to address complications in adult spinal deformity by optimizing spinopelvic fixation vis-à-vis the unique biomechanics of the SI joint. The sacropelvic system is a surgical solution which provides an additively manufactured implant at the base of the spine employing an S2AI trajectory while utilizing assisting technologies including surgical navigation and intraoperative neurophysiological monitoring.

Vorrichtung zur Herstellung von Tabletten

Resumen de: DE102024107712A1

Die Erfindung betrifft eine Vorrichtung (1) zur Herstellung von Tabletten (2), wobei die Vorrichtung (1) eine Vorläufermaterialherstellungseinrichtung (3) und eine additive Fertigungseinrichtung (4) aufweist, wobei die Vorläufermaterialherstellungseinrichtung (3) ausgebildet ist, um über einen Arzneistoff (5) verfügende Granulatpartikel (6) mit einem ein thermoplastisches Material (7) aufweisenden Beschichtungsmittel (8) zu beschichten, um Vorläufermaterialpartikel (9) zu erzeugen, und wobei die additive Fertigungseinrichtung (4) ausgebildet ist, um aus einem über eine Vielzahl von Vorläufermaterialpartikeln (9) verfügenden pulverförmigen Vorläufermaterial (10) durch selektives Lasersintern Tabletten (2) herzustellen.

IMPLANT SYSTEM AND METHOD FOR JOINT FUSION

Resumen de: US2025288331A1

Implant systems and methods treatment of a joint include a distal portion, a middle portion, and a proximal portion. The distal portion may include a thread having a first thread minor, a first thread major, and a first pitch. The distal portion also may have a reverse cut, helical fenestration formed through the thread. The middle portion may be devoid of threads and may include a porous outer surface structure to promote bony integration, the porous outer surface structure having a leading end and a trailing end, with the leading end having a diameter larger than the first thread minor. The proximal portion may include a proximal thread having a second thread minor, a second thread major, and a second pitch. The second thread minor may be substantially the same width as the trailing end of the middle portion.

SPRAYED MULTI ADSORBED-DROPLET REPOSING TECHNOLOGY (SMART)

Resumen de: US2025288524A1

Described are techniques, systems, and methods include those employing pneumatic, pressure assisted, extrusion-based 3D printing and emulsion evaporation, emulsion diffusion, nanoprecipitation, desolvation, gelation, spray-based atomization, etc. for fabricating loaded microparticles or nanoparticles that encapsulate an active pharmaceutical ingredient or live cells into a biocompatible polymer or pharmaceutical excipients. The techniques provide for encapsulation of a variety of substances including proteins, plasmid DNA, lipophilic pharmaceutical compositions, hydrophilic pharmaceutical compositions, live cells, and/or cellular components into polymeric microparticles or nanoparticles. The particles loaded with active pharmaceutical ingredients can be used for the treatment of different diseases or conditions. The particles loaded with live cells can be used for disease treatment, but can also be used for securely storing the live cells in a stable condition for transport and later use in inoculating fermentation systems, for example, to generate recombinant proteins.

MULTI-VALENT POLYMERIZABLE COMPOSITIONS AND METHODS OF PRODUCING AND USING THE SAME

Resumen de: US2025289921A1

The present disclosure provides photo-polymerizable components, photo-curable resins comprising one or more of such monomers, as well as polymeric materials formed from the photo-curable resins. Further provided herein are methods of producing the compositions and using the same for the fabrication of medical devices, such as orthodontic appliances.

3D PRINTED COMPOSITES FROM PHASE SEPARATED MATERIALS

Resumen de: US2025289919A1

The present disclosure provides methods, systems, devices, and kits for creating composite materials from a single resin, the composite materials having multiple continuous phases. The disclosure includes a process to three-dimensionally print objects (e.g., orthodontic appliances) with composite properties. In some aspects, the composite properties are formed from a single formulation with components that, when processed, have hard and soft continuous phases. In some aspects, the composite properties are formed by separately processing the hard phase components and the soft phase components. In some aspects, the composite materials and devices are three-dimensionally printed using the processed material.

FUNCTIONALIZED AND CROSSLINKED POLYMERS

Resumen de: US2025289909A1

Polyhydric polymers may be converted to derivatives thereof by reaction with divinyl sulfone to provide vinyl sulfone substituted polymers, where the polymers may additionally be further derivatized, including crosslinked, and the crosslinked and non-crosslinked derivatives may be used in biomedical and other applications.

Verfahren zur Herstellung von Tabletten

Resumen de: DE102024107710A1

Die Erfindung betrifft ein Verfahren zur Herstellung von Tabletten (2), wobei dass das Verfahren einen Beschichtungsschritt und einen auf den Beschichtungsschritt folgenden additiven Fertigungsschritt aufweist, wobei im Beschichtungsschritt über einen Arzneistoff (5) verfügende Granulatpartikel (6) mit einem ein thermoplastisches Material (7) aufweisenden Beschichtungsmittel (8) beschichtet werden, um Vorläufermaterialpartikel (9) zu erzeugen und im additiven Fertigungsschritt ein selektives Lasersintern eines über eine Vielzahl von Vorläufermaterialpartikeln (9) verfügenden pulverförmigen Vorläufermaterials (10) zu Tabletten (2) durchgeführt wird.

3D PRINTED STRUCTURALLY SOUND PROSTHETIC SOCKET

Resumen de: US2025288423A1

A method for 3D printing a prosthetic socket from a digital model, including printing a solid wall perimeter of the prosthetic socket with a width achieved in a single pass of a printing nozzle, and forming a plurality of stiffener elements proximate a bottom end of the prosthetic socket, as a function of the printing the solid wall perimeter, is provided. Also provided is a 3D printed prosthetic socket including an upper portion, a lower portion configured to be attached to a prosthetic pylon, and a plurality of stiffener elements radially extending from the lower portion, wherein the upper portion, the lower portion, and the plurality of stiffener elements are printed as a solid wall construction comprised of a printing material deposited using only a single pass of a printing nozzle.

COLLAPSIBLE INNER FLOW CONTROL COMPONENT FOR SIDE-DELIVERABLE TRANSCATHETER HEART VALVE PROSTHESIS

Resumen de: EP4617061A2

A side-deliverable prosthetic heart valve includes an outer frame and a flow control component. The outer frame defines a central channel that extends along a central axis. The flow control component is disposed within the central channel and coupled to the outer frame. The flow control component has a set of leaflets mounted within an inner frame. The prosthetic valve is configured to be folded along a longitudinal axis and compressed along the central axis to place the prosthetic valve in a compressed configuration for delivery via a delivery catheter. The longitudinal axis is substantially parallel to a lengthwise axis of the delivery catheter when disposed therein. The prosthetic valve transitions to an expanded configuration when released from the delivery catheter. The flow control component elastically deforms from a substantially cylindrical configuration to a substantially flattened configuration when the prosthetic valve is placed in the compressed configuration.

A DETACHABLE PRINTHEAD FOR A BIOPRINTER AND A BIOPRINTER

Resumen de: AU2023377822A1

A detachable printhead for a bioprinter is disclosed, the detachable printhead comprising a body, removably attachable to a fixed portion of the bioprinter; a dispensing system, supported by the body; one or more reservoirs, for holding one or more biomaterials, in fluid communication with the dispensing system, supported by the body; and a coupling for attaching to the fixed portion of the bioprinter, the coupling including an interface for operating the dispensing system.

LOAD-CARRYING ROD

Resumen de: WO2024100147A1

A load-carrying rod (1) for an implant system has a structure of individual interconnected solidified droplets (4) so that the transitions from one droplet to another act as crack stoppers in the event of a crack.

DYNAMIC HYDROGEL COMPOSITIONS

Resumen de: AU2023375461A1

Compositions and methods for delivery of therapeutic agents to an individual in need thereof, for prevention/reduction of tissue adhesion, and for 3D printing are disclosed herein. In some embodiments, the composition comprises octadecyl modified hydroxypropyl methylcellulose (HPMC-C18) and a surfactant or cyclic polysaccharide, wherein the composition is a hydrogel that exhibits dynamic properties.

複合生体材料

Resumen de: MX2021013857A

Provided herein are composite scaffold biomaterials including two or more scaffold biomaterial subunits, each including a decellularized plant or fungal tissue from which cellular materials and nucleic acids of the tissue are removed, the decellularized plant or fungal tissue having a 3-dimensional porous structure, the two or more scaffold biomaterial subunits being assembled into the composite scaffold biomaterial and held together via gel casting using a hydrogel glue; via complementary interlocking geometry of the two or more scaffold biomaterial subunits; via guided assembly based biolithography (GAB); via chemical cross-linking; or any combinations thereof. Methods for producing such scaffold biomaterials, as well as methods and uses thereof, are also provided.

三维光造型用固化性组合物及其制造方法、三维光造型物的制造方法以及牙科用修复物的制造方法

Resumen de: AU2024218051A1

The present invention provides a curable composition for three-dimensional stereolithography, the curable composition being used in a vat photopolymerization method and containing 100 parts by mass of a polymerizable monomer component (A), 40 parts by mass to 400 parts by mass of an inorganic filler (B) that is composed of a single kind or plural kinds of inorganic particulate matter, and 0.01 part by mass to 5 parts by mass of a photopolymerization initiator (C), wherein: 80% or more of all primary particles that constitute the inorganic filler (B) have a particle diameter of 0.05 µm to 5.0 µm; and a sample, which is formed of this curable composition for three-dimensional stereolithography and has a thickness of 0.5 mm, has a transmittance of 1.00% to 50.00% with respect to activation light. The present invention also provides a method for producing this curable composition for three-dimensional stereolithography. The present invention also provides a method for producing a three-dimensional stereolithographic model and a method for producing a dental restoration, each using this curable composition for three-dimensional stereolithography.

光造型用树脂组合物

Resumen de: US2022371264A1

The present invention provides a resin composition for stereolithography that enables easy stereolithographical fabrication; and that can produce a cured object having desirable strain recovery, desirable toughness, and desirable water resistance. The present invention relates to a resin composition for stereolithography comprising a polymerizable compound (A) whose homopolymer has a glass transition temperature (Tg) of 37° C. or higher; and a photopolymerization initiator (B), and having a tan δ at 37° C. of 0.3 or less after cure.

一种3D打印生物墨水及其制备方法和应用

Resumen de: CN120643748A

本发明提供一种3D打印生物墨水及其制备方法和应用。所述3D打印生物墨水包括如下组分：甲基丙烯酸酐化明胶、氧化透明质酸、羧甲基壳聚糖和2‑甲基丙烯酰氧乙基磷酸胆碱。本发明通过对3D打印生物墨水的具体组成进行设计，制备得到了打印性能好、力学强度好、电传导性能好、打印后细胞存活率高的3D打印生物墨水，进而制备得到了细胞‑支架相互作用较强的3D打印支架，可用于制备皮肤损伤修复材料。

微结构的增材制造

Resumen de: WO2024165390A1

The invention relates to a method for additive manufacturing of a microstructure (10) for selective transmission of X-ray or gamma-ray radiation. The method includes depositing (110) a layer of powder on a build plate or on a layer from at least one previous manufacturing step on the build plate, wherein the layer of powder comprises a high-Z material powder. Furthermore, the method includes selectively melting (120) and solidifying the powder to form septa wall structures (20) by scanning an electron beam in a spot sequence on the layer of powder to sequentially expose a plurality of spots (40) on the layer of powder to an electron beam spot. A size of the electron beam spot is at most 150 μm in diameter, preferably at most 75 μm in diameter, and more preferably at most 50 pm in diameter. The high-Z material powder comprises a high-Z material having an atomic number Z of at least 40, and preferably at least 70. The invention also relates to a microstructure for selective transmission of X-ray or gamma-ray radiation, which microstructure has been obtained by the method, and to an imaging component comprising such microstructures. The invention also relates to a method for manufacturing an imaging component.

Chamber with a flow system for bioprinting and culturing tissue models

Resumen de: PL132037U1

Przedmiotem zgłoszenia jest komora z układem przepływowym do biodrukowania i hodowli modeli tkankowych zawierająca: korpus (1) komory z otworem środkowym przesłoniętym szkiełkiem dolnym (2), przykryty z wierzchu pokrywą (3) zaopatrzoną w otwór środkowy przesłonięty szkiełkiem górnym (5), przy czym pomiędzy korpusem (1) komory i pokrywą (3) komory znajduje się silikonowa uszczelka obwodowa (4), gdzie korpus (1) komory na swoich dwóch przeciwległych końcach zaopatrzony jest w złącza (8) z kanałami łączącymi (10) zapewniającymi połączenie płynowe z objętością roboczą komory wyznaczoną przez ściany wewnętrzne korpusu (1) komory i pokrywy (3), uszczelkę obwodową (4) i powierzchnie wewnętrzne szkiełka dolnego (2) i szkiełka górnego (5) skierowane ku sobie nawzajem, gdzie układ przepływowy jest utworzony przez złącza (8) wraz z kanałami łączącymi (10) oraz objętość roboczą komory zawartą pomiędzy nimi; oraz obudowę zewnętrzną komory złożoną z ramki dolnej (6) i ramki górnej (7), przy czym korpus (1) komory i pokrywa (3) komory wraz z elementami zawartymi pomiędzy nimi są zamknięte pomiędzy ramką dolną (6) i ramką górną (7) obudowy zewnętrznej, które połączone są ze sobą rozłącznie.

Casing that strengthens and seals the bioprinted tissue model

Resumen de: PL132035U1

Obudowa wzmacniająca i uszczelniająca biodrukowany model tkankowy, składająca się z modułu wewnętrznego oraz zewnętrznego, moduł wewnętrzny zawiera: podstawę składającą się z dna w kształcie prostokąta o zaokrąglonych rogach i ścian bocznych, przy czym na jednej z krótszych ścian bocznych, po stronie zewnętrznej znajdują się dwa elementy mające kształt tulei, usytuowane obok siebie; średnica elementów jest mniejsza niż wysokość ściany bocznej; i pokrywę składającą się z powierzchni górnej w kształcie prostokąta o zaokrąglonych rogach i ścian bocznych, przy czym na jednej z krótszych ścian bocznych znajdują się dwa otwory o kształcie ściętego koła, odpowiadające wielkością elementom w kształcie tulei, przy czym pokrywa na całej górnej powierzchni posiada perforacje, przy czym po złożeniu podstawy i pokrywy ściany boczne podstawy znajdują się wewnątrz modułu, a ściany boczne pokrywy znajdują się na zewnątrz modułu wewnętrznego, wysokość ścian bocznych jest dobrana w taki sposób, aby po złożeniu ściany zewnętrzne zakrywały całkowicie ściany wewnętrzne, moduł zewnętrzny zawiera: pojemnik, o kształcie otwartego prostopadłościanu posiadającego zaokrąglone rogi i pokrywę zewnętrzną (8), zamykającą pojemnik (7), przy czym powierzchnia górna (P) pokrywy zewnętrznej (8) posiada dwa otwory (9), które rozmiarem i rozmieszczeniem odpowiadają elementom znajdującym się w module wewnętrznym, p

A BIORESORBABLE CARDIOVASCULAR STENT (BCS) AND ITS METHOD OF PREPARATION THEREOF

Resumen de: WO2025186835A1

The present invention discloses a bioresorbable cardiovascular stent (100). The bioresorbable cardiovascular stent (100) comprising at least one strut (104) (110) connecting the plurality of rhombus-shaped cells (102) in both the longitudinal directions and the circumferential directions and each strut (104) (110) provided with a consistent thickness (108) and width (106). The stent (100) maintains a uniform thickness (108) throughout its length, and featuring struts (104, 110) with consistent thickness (108). The stent (100) is manufactured by using a micro-injection molding process with a single sprue-less hot runner gate. The bioresorbable cardiovascular stent (100) is configured to maintain structural integrity, biocompatible properties, improve radial stiffness to (612 kPa/mm) and radial strength to (225 kPa).

一种拔牙创护板

Resumen de: CN223323622U

本实用新型提供一种拔牙创护板，涉及口腔医学技术领域，拔牙创护板包括护板主体，护板主体用于封堵牙槽窝，护板主体的两侧均设置有翼部，翼部向护板主体朝向牙槽窝的一侧延伸，一个翼部用于卡设于牙槽窝的颊侧牙龈，另一个翼部用于卡设于牙槽窝的舌侧牙龈。本实用新型实施例提供的拔牙创护板，可发挥物理屏蔽保护及压迫止血作用，可以在底部放置止血填塞类材料，也可以通过给药孔进行药物补充。该装置的应用有利于拔牙窝的愈合，减少患者止血失败、感染、干槽症等拔牙并发症的风险；且术后患者在进食及口腔卫生护理等过程中，持续隔离保护创口，能够大大改善患者拔牙术后的体验感；患者一般无需再次就诊，拔牙创口完全愈合后，取下护板即可。

一种带环喷码工装夹具

Resumen de: CN223327186U

本申请公开了一种带环喷码工装夹具，其包括底板、设置于所述底板顶部前侧的上模、设置于所述底板顶部后侧的下模，所述上模与所述下模相互对应，所述底板顶部还均匀固定设有若干定位板，若干所述定位板位于所述上模与所述下模之间，所述上模上均匀固定设有若干角码块，所述角码块位于所述定位板右侧，所述下模上均匀固定设有若干固定板，所述夹具通过调节所述固定板、所述角码块与所述定位板之间的间距来实现对不同规格所述带环的夹紧固定。

一种3D打印功能增强的聚醚醚酮复合材料及其制备方法

Nº publicación: CN120617629A 12/09/2025

Solicitante:

浙江中聚生物科技有限公司

Resumen de: CN120617629A

本发明涉及3D打印用生物材料技术领域，特别涉及一种3D打印功能增强的聚醚醚酮复合材料及其制备方法。一种3D打印功能增强的聚醚醚酮复合材料，该材料包括如下质量份数的原料：聚醚醚酮75‑85份，改性生物活性材料5‑10份，碳纳米管1‑3份，有机成核剂0.5‑2份，生物调节剂0.1‑1份，抗菌剂0.1‑1份；所述改性生物活性材料为改性羟基磷灰石和/或改性磷酸三钙。该基本配方实现了多功能组分的协同作用，通过精心配比的聚醚醚酮、改性生物活性材料、碳纳米管等成分，解决了现有PEEK材料在生物活性和结晶性能方面的不足，并提供了优异的力学性能和生物相容性。