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用于制造金属嵌入式医疗植入物和装置的三维打印方法

Resumen de: WO2024093647A1

Three-dimensional (3D) printing methods for making metal-embedded medical implants and devices are provided. The newly developed 3D printing technology and surface modification method will contribute to the wider application of 3D-printed patient-specific products in many medical fields showing excellent clinical safety.

一种3D打印肝癌切除手术导板的制造方法

Resumen de: CN120392288A

本发明涉及医学领域，且公开了一种3D打印肝癌切除手术导板的制造方法，包括以下步骤：CT数据采集：进行肝脏增强扫描，获取多期DICOM格式数据；应用3D可视化软件，以门静脉4级分支流域为基础，规划肝脏切除范围并确定手术切面；应用3‑matic Medical等工程软件，基于手术切面设计肝脏表面及实质内手术导板；使用3D打印机将数字手术导板打印为实物模型，用于手术定位与导航。传统的肝癌手术规划建立在标准的肝脏分段方法之上，缺乏个性化。目前主要应用肝蒂阻断法及染料注射法进行手术路径导航，存在操作复杂、成功率低、重复性差等问题。本发明为一种3D打印肝癌切除手术导板的制造方法，通过3D数字技术实现手术科学规划与精确导航。通过本技术方法提高手术的根治性与安全性，增进肝癌治疗效果。

一种牙模3D打印控制系统

Resumen de: CN120396331A

本发明提供了一种牙模3D打印控制系统，包括：LCD屏幕、用于发射紫外光的UV光源、用于附着已固化模型的成型平台、盛放液态陶瓷填充光敏树脂的料槽、墨盒、带动成型平台与墨盒移动的Z轴和X轴电机、丝杠以及传感器。所述墨盒外部配备磁铁结构，可紧密吸附在料槽的钢板上；磁铁外围集成刮刀组件，使得墨盒在运动过程中能够同时对浆料进行均匀刮平；墨盒顶部配备墨盒盖。本系统不仅优化了料槽设计，还配备了自动供料墨盒，以在打印过程中动态补充浆料，同时利用墨盒中的刮刀组件确保浆料均匀分布，优化固化质量。这种设计有效避免了传统光固化3D打印机因浆料供给不足或分布不均而导致的打印缺陷。

一种载姜黄素3D生物打印墨水及其制备方法与应用

Resumen de: CN120393112A

本发明公开了一种载姜黄素3D生物打印墨水及其制备方法与应用，属于3D生物打印材料技术领域。该制备方法具体包括以下步骤：(1)包载物的制备；(2)姜黄素纳米粒子溶液的制备；(3)载姜黄素3D生物打印墨水的制备。本发明采用物理混合的方法将姜黄素纳米粒子溶液和高分子粉末混合，由此制得的载姜黄素3D生物打印墨水具有显著的抗炎活性和较好的促进伤口愈合效果，同时具有较好的可打印性和ROS响应释放特性，可用于载药医疗器械，对提高姜黄素的给药精确性具有重要意义。而且，本发明制备方法操作简单，效果显著，应用范围广，能拓宽载姜黄素3D生物打印墨水的应用范围，具有良好的应用前景。

基于柔性糖牺牲载体的可注射中空支架及其制备方法

Resumen de: CN120393118A

本发明涉及一种基于柔性糖牺牲载体的可注射中空支架及其制备方法，将蔗糖、果糖、葡聚糖、葡萄糖混合溶解到蒸馏水中，高温持续搅拌得到粘稠溶液，高温交联得到糖打印材料；利用糖打印材料在平面内打印柔性糖网平面基材，为软质柔性可形变状态；对柔性糖网平面基材进行塑形，得到柔性糖牺牲载体，将PCL涂层液多层涂覆到柔性糖牺牲载体，得到双层支架；置于蒸馏水中溶解柔性糖牺牲载体，得到可注射中空支架。本发明通过精确控制柔性糖牺牲载体中各组分的比例，令其性状可一段时间内维持软质柔性可形变状态，仅需要在二维平面内打印出基材，然后塑型处理，实现对特定器官形态的模拟，提高了复杂器官重建的准确性和可行性。

椎间融合器用近红外3D打印硅橡胶复合材料及其制备方法

Resumen de: CN120393108A

本发明公开了椎间融合器用近红外3D打印硅橡胶复合材料及其制备方法，将YbCl3·6H2O与TmCl3·6H2O/ErCl3·6H2O/PrCl3·6H2O按摩尔比(Tm:Er＝1:0.2～0.5或Tm:Er:Pr＝1:0.2～0.5:0.1～0.3)溶于水，与EDTA‑2Na、NaF、AgNO3反应制得NaYbF4:M/Ag；再经SiO2包覆和CTAB/硅烷改性获得硅烷改性NaYbF4:M@SiO2复合粒子；再将其与热/光固化硅橡胶单体、引发剂及羟基磷灰石混合制得近红外光‑热协同固化硅橡胶墨水。该材料可实现高精度3D打印，兼具良好生物相容性和力学性能，适用于椎间融合器医疗硅橡胶制品的制备。

透明な歯科矯正アタッチメントを製造するための硬化性組成物

Resumen de: CN119584936A

The present invention relates to a curable composition comprising: a (meth) acrylate free of urethane moieties, a urethane (meth) acrylate, a photoinitiator, discrete filler particles having an average particle size in the range of 10 nm to 40 nm and having been surface treated with a silane surface treatment agent, the silane surface treatment agent is selected from the group consisting of silane surface treatment agents comprising (meth) acrylate moieties, silane surface treatment agents not comprising (meth) acrylate moieties, and mixtures of both, and the discrete filler particles are present in an amount of 20% by weight or more, the curable composition further comprising an additive selected from the group consisting of silane surface treatment agents comprising (meth) acrylate moieties, silane surface treatment agents not comprising (meth) acrylate moieties, silane surface treatment agents not comprising (meth) acrylate moieties, and mixtures of both. The curable composition does not contain, in each amount of 2 wt% or more, aggregate of nano-sized particles, fumed silica, wt% relative to the curable composition, alone or in combination: aggregate of nano-sized particles, aggregate of nano-sized particles, fumed silica.

SYSTEM AND METHOD FOR GLAZING DENTAL RESTORATIONS WITH CERAMIC INK VIA INKJET PRINTER

Resumen de: US2025241734A1

Disclosed are systems and methods of a decision intelligence (DI)-based computerized framework that automatically and/or dynamically implements a color algorithm for performing staining and glazing dental restorations. The framework operates by leveraging determined color variations through AI/ML-based analysis that generate detailed color maps, which can be translated into precise printing instructions controlling the mixture and layering of dental-grade glazing materials. A printing system can employ multiple print heads with varying base colors and opacity levels to create microscopic color gradients and translucency effects matching natural tooth enamel. The disclosed automated processing applies personalized color patterns in microscopically thin layers, ensuring consistent glaze thickness while replicating regional variations across the tooth surface. Such approach eliminates manual glazing variability while achieving superior customization compared to traditional pre-set patterns, resulting in dental restorations that integrate seamlessly with existing teeth.

3D BIOPRINTED HYDROGEL MICROFLUIDIC SYSTEMS AND PERFUSION BIOREACTORS FOR ENGINEERING VASCULARIZED TISSUE CONSTRUCTS

Resumen de: WO2025160474A1

3D bioprinted hydrogel microfluidic systems and perfusion bioreactors for engineering vascularized tissue constructs are provided. An example of an internally perfusable scaffold comprises an exterior surface, a body, a first port, and an interior wall. The first port comprises a first coupling feature configured to engage a fitting and form a fluid tight seal therewith. The first interior wall defines a fluid cavity extending into the body from the first port. The scaffold comprises a hydrogel.

FEATURES FOR IMPLANTS WITH A REDUCED VOLUMETRIC DENSITY OF SURFACE ROUGHNESS

Resumen de: US2025241765A1

The invention disclosed herein includes implant features that can be used, in some embodiments, on devices with a volumetric density of less than about 100 percent and devices with a surface roughness of some value. The implant features include one or more protrusions mounted on the forward edge of an implant that can ease the distraction of tissue during implantation and reduce the occurrence of damage during a manufacturing process. In some embodiments, the protrusions have gaps in a non-axial direction with respect to the implant to allow axial compression with respect to the protrusions. In some embodiments, the protrusions have a circumferential gap between them and a body of a device to reduce any impact on the device's elastic modulus.

SYSTEM AND METHOD FOR CERAMIC INKJET MESH PRINTING

Resumen de: US2025241735A1

Disclosed are systems and methods for a computerized framework for automated ceramic inkjet printing in dental restoration manufacturing. The disclosed ceramic inkjet mesh printing for dental restorations combines precision digital control with ceramic materials to create highly accurate and aesthetically pleasing dental prosthetics. The disclosed mechanisms utilize specialized printheads designed to deposit precise amounts of ceramic materials onto dental substrates, enabling the creation of detailed color gradients and natural-looking surfaces that closely mimic natural teeth.

MINIMALLY INVASIVE AND ENDOSCOPIC IN-VIVO BIOPRINTING SYSTEMS AND METHODS

Resumen de: US2025242171A1

A system may include a donor supply sub-system configured to supply donor material to a donor substrate. The system may include a material transfer sub-system comprising a laser configured to illuminate the donor substrate via a transfer beam. The system may include an instrument head of a medical instrument configured to house the donor substrate, wherein upon an illumination of the donor substrate, the donor material is transferred to receiver material in vivo.

Spinal Implant With Porous And Solid Surfaces

Resumen de: US2025241766A1

A spinal implant including porous and solid portions is disclosed. The implant includes porous portions on upper and lower surfaces and in an interior thereof. Methods of manufacturing and implanting such implants are also disclosed.

NOVEL POLYMER

Resumen de: US2025242078A1

The present invention relates to a functionalised polymer, methods of preparing the functionalised polymer, and compositions comprising the functionalised polymer. The present invention also relates to methods of using the functionalised polymer including for forming a polymer composition comprising cells from a tissue sample and for cell therapy.

3D-PRINTED, WELL PLATE-INTEGRATED PIEZOELECTRIC CANTILEVER SENSORS FOR CELL CULTURE MONITORING

Resumen de: US2025243447A1

A hybrid microextrusion pick-and-place 3D printing process enables fabrication of 3D-printed well plate-integrated piezoelectric cantilever sensors for monitoring properties and composition of tissue culture models. 3D-printed piezoelectric cantilever sensors exhibit multiple resonant modes across the 1-150 kHz frequency range. The ability to control cantilever frequency response (i.e., mode locations and types) was demonstrated by variation in the 3D-printed anchor geometry through corresponding changes in tool path and microextrusion process parameters. 3D-printed piezoelectric cantilever sensors facilitated in situ monitoring of cell culture media density and viscosity. This work presents an advance in the fabrication of cantilever sensors through the use of hybrid 3D-printing and pick-and-place processes that improves sensor reproducibility and enables novel control over anchoring of piezoelectric components and sensor integration with both 2D and 3D cell culture models, particularly 3D-bioprinted tissue constructs and microphysiological systems.

METHOD AND SYSTEM FOR MERGING BIO-ELECTROSPRAYING, CELL ELECTROSPINNING MERGED WITH 3D MULTIMATERIAL MICROFLUIDIC BIOPRINTING FABRICATE HUMAN TISSUES FOR DRUG DISCOVERY APPLICATIONS

Resumen de: US2025243452A1

The present invention provides a method and system for fabricating complex human tissues by integrating bio-electrospraying, cell electrospinning merged with 3D multi material microfluidic bioprinting, and future additions of magnetic and acoustic levitation technologies. The fabricated tissues serve as an alternative to animal testing in drug discovery processes, aiding in the prediction of human physiological responses to various drug compounds.

METHODS OF PRODUCING MULTI-LAYERED TUBULAR TISSUE CONSTRUCTS

Resumen de: US2025243465A1

Described are methods for producing multi-layered tubular tissue structures, tissue structures produced by the methods, and their use.

CERAMIC DEVICES AND METHODS OF MAKING AND USING THE SAME

Resumen de: US2025243128A1

The present invention relates to methods for preparing ceramic devices having a surface that has been activated to enhance properties including strength, porosity, and bioactivity. Activation may include forming a gel layer on the surface of a ceramic device using an alkali solution and modifying the surface using a modifying material. The invention further relates to ceramic devices prepared by the methods and methods of using the devices.

System and method for producing pharmaceutical objects via 3D printing

Resumen de: AU2025205378A1

21894047_1 (GHMatters) P119307.AU.2 The invention relates to a system for producing pharmaceutical objects, such as tablets, granules and capsules, via 3D print- ing. The system comprises a 3D printing machine (2) with a me-5 chanical system (3) movable in one or more directions, at least one print head (5) with a nozzle (37) being movable by the me- chanical system (3) and a base system (4) carrying a print base (6) for receiving a prepared mixture (27) applied by the print head (5). The system comprises at least one carrier (35) for 10 holding a cartridge (28).Printing can be done on formatted print locations (49) on the base (6). The invention further relates to a method for producing pharmaceutical objects, comprising the steps of providing at least one pharmaceutical substance in at least one cartridge, placing the cartridge in a carrier, estab-15 lishing a fluid connection between a cartridge and a print head, such that the pharmaceutical substance may leave the print head through the print head nozzle, moving the print head nozzle ac- cording to a 3D print program and dispensing the pharmaceutical substance to a print base. 20 (Fig. 24) The invention relates to a system for producing pharmaceutical objects, such as tablets, granules and capsules, via 3D print- 5 ing. The system comprises a 3D printing machine (2) with a me- chanical system (3) movable in one or more directions, at least one print head (5) with a nozzle (37) being movable by the me- chanical system (3)

GUIDE PLATE FOR THE ANATOMICAL REALIGNMENT OF BONE FRACTURES

Resumen de: WO2024062369A1

Guide plate for the anatomical realignment of a plurality of fractured bone portions, comprising a back surface configured such as it can be distinctively coupled to the surface anatomy of the area of said plurality of fractured bone portions and characterized by a first plurality of holes placed on a first portion of the guide plate and a second plurality of holes placed on a second portion of the guide plate, wherein the first plurality of holes is misaligned with respect to the second plurality of holes.

SYSTEMS, APPARATUSES, AND METHODS FOR CREATING TISSUE INTERFACES

Resumen de: WO2024062324A1

A system for creating a tissue interface. The system includes a scanner, at least one processor, and a memory. The scanner is configured to scan a tissue site and generate a signal corresponding to a topography of the tissue site. The at least one processor is configured to receive the signal corresponding to the topography of the tissue site and to receive user input at a user interface identifying a therapy to be applied at the tissue site. The memory is coupled to the at least one processor and is configured to store instructions that when executed by the at least one processor in response to receiving the signal corresponding to the topography of the tissue site cause the system to transform the signal corresponding to the topography of the tissue site into a model site surface and generate a model tissue interface.

MODULAR BUILD PLATFORMS FOR ADDITIVE MANUFACTURING

Resumen de: US2024100775A1

Systems, methods, and devices for additive manufacturing are provided. In some embodiments, a method includes: coupling a plurality of build platforms to a carrier; forming a plurality of 3D objects on the plurality of build platforms using an additive manufacturing process, where each build platform receives at least one 3D object thereon; removing the plurality of build platforms from the carrier; performing post-processing of the plurality of 3D objects while the 3D objects remain on the respective build platforms; and separating the plurality of 3D objects from the respective build platforms.

THIOL-ENE HYDROGEL

Resumen de: CN119997989A

A hydrogel string for encapsulating a biological material is provided. A hydrogel string has a thiol-ene cross-linked polymer having a first side chain functionalized backbone polymer functionalized with an activated olefin that is cross-linked with a free or protected thiol-containing group present on a second side chain functionalized backbone polymer. The biological material is encapsulated in a thiol-ene cross-linked polymer.

CELL MACROENCAPSULATION DEVICES, METHOD OF FABRICATION AND USE THEREOF

Resumen de: WO2024059942A1

It is provided a cell macroencapsulation device for implanting cells in a recipient comprising cells encapsulated in a porous membrane, wherein the porous membrane consists of a sugar network coated with a polymeric solution comprising porogen, which can be used as a graft to transplant islets while protecting the graft from the immune system as well as providing enhanced convection and diffusion to ensure long-term cell survival and physiological insulin delivery.

BIOPRINTED SOFT TISSUE REINFORCEMENT SCAFFOLD

Nº publicación: EP4590232A1 30/07/2025

Solicitante:

ETHICON INC [US]
T & R BIOFAB CO LTD [KR]
Ethicon, Inc,
T&R Biofab Co. Ltd

Resumen de: CN119968177A

The present disclosure encompasses systems, compositions, and methods for use in vivo, including for enhancing soft tissue in an individual. The systems, compositions, and methods may utilize a three-dimensionally printed scaffold comprising at least a polymeric scaffold and an extracellular matrix component, including an extracellular matrix component contained on the scaffold. The polymer scaffold may include specific unit cell structures having a specific design and a pattern of alternating configurations of unit cell structures.