Alerta

METHOD FOR PROVIDING DENTAL ALIGNERS TO A SUBJECT SHOWING A NON-ALIGNEMENT OF ITS DENTITION

Resumen de: US2025345151A1

A personalized method for providing at least one dental aligner; the method being with reference to an actual state of the dentition of the patient and in view of an improvement plan of the alignment targeted over a period of time ranging from 1 to 16 weeks, of the teeth of a subject. The method includes the steps of: (i) providing a 2D image and/or 3D volume of the dentition of a subject showing a non-alignment of its dentition; (ii) recovering clinical markers of the subject; (iii) producing an initial set of manufacturing parameters of the at least one aligner; (iv) building up an image of the 1-16 weeks target of improvement; and (v) directly 3D printing of the at least one personalized aligner fitting with the predicted evolution of intermediate tooth displacement for each tooth of the patient during the improvement plan.

3D PRINTING COMPOSITIONS FOR STAIN RESISTANT AND MORE TRANSPARENT DENTAL MATERIALS FROM POLYOLEFIN DERIVED POLYOLS

Resumen de: US2025346708A1

The present disclosure provides novel oligomer compounds (e.g., non-polar oligomers) that can produce desirable polymeric materials (e.g., with polar reactive diluents), polymer compositions, and/or photo-curable resins that have excellent stain resistance. Further provided herein are methods of producing polymerizable compositions, resins, devices, and polymeric materials. Also provided herein are methods of using polymerizable compositions, resins, and polymeric materials for the fabrication (e.g., via 3D printing) of medical devices, such as orthodontic appliances with increased stain resistance.

Verfahren zum Fertigen eines Hüftimplantats, individualisiertes Hüftimplantat

Resumen de: DE102024112836A1

Die Erfindung betrifft ein Verfahren zum Fertigen eines Hüftimplantats (20), wobei das Verfahren umfasst: Bereitstellen eines Patienteninformationsdatensatzes (72), der Informationen zu einer Form eines Hüftbeins (10) mit einem Hüftpfannendefekt (11) umfasst, Erzeugen eines Formdatensatzes (76), der Informationen zu einer Sollform für ein Hüftimplantat für den Hüftpfannendefekt umfasst, wobei die Sollform eine Individualkomponente (32,38,44,54) aufweist, deren Abmessung und/oder Anordnung durch wenigstens einen veränderbaren Geometrieparameter charakterisiert sind, und wobei das Erzeugen des Formdatensatzes das Festlegen des wenigstens einen Geometrieparameters in Abhängigkeit von dem Patienteninformationsdatensatz umfasst, und Fertigen eines individualisierten Hüftimplantats in Abhängigkeit von dem Formdatensatz. Die Erfindung betrifft außerdem ein individualisiertes Hüftimplantat.

Drucktinte zur Herstellung von Gewebe und Verfahren zu deren Herstellung sowie Verfahren zur Herstellung von Gewebe und mit dem Verfahren herstellbares Gewebe

Resumen de: DE102024204366A1

Die vorliegende Erfindung betrifft eine Drucktinte zur Herstellung von Gewebe, vorzugsweise physiologischem Gewebe. Die Drucktinte umfasst mindestens einen Polyelektrolytkomplex und Wasser, wobei der mindestens eine Polyelektrolytkomplex mindestens ein Strukturprotein sowie mindestens ein anionisches Polysaccharid und/oder Polysaccharid-Derivat enthält oder daraus besteht, und wobei das mindestens eine anionische Polysaccharid und/oder Polysaccharid-Derivat in einer Konzentration von mindestens 0,1 mg/ml in der Drucktinte enthalten ist. Zudem betrifft die vorliegende Erfindung auch ein Verfahren zur Herstellung der erfindungsgemäßen Drucktinte, ein Verfahren zur Herstellung von Gewebe, in welchem die erfindungsgemäße oder erfindungsgemäß hergestellte Drucktinte verwendet wird, sowie ein mit dem Verfahren herstellbares oder hergestelltes Gewebe.

System, Method, and Apparatus for Remote Patient Care

Resumen de: US2025346051A1

A portable patient-care kit is disclosed. The kit includes a housing, a plurality of compartments and a touch-screen user interface device. The housing forms a container space. The plurality of compartments is disposed within the container space such that each compartment is configured to retain at least one medical apparatus. The touch-screen user interface device has a transceiver that can communicate via a mobile data network.

PIEZOELECTRIC COATED IMPLANTS AND METHODS OF USING PIEZOELECTRIC COATED IMPLANTS TO REPAIR BONE STRUCTURES

Resumen de: AU2025259808A1

TITLE: PIEZOELECTRIC COATED IMPLANTS AND METHODS OF USING 5 PIEZOELECTRIC COATED IMPLANTS TO REPAIR BONE STRUCTURES Various embodiments of implant systems and related apparatus, and methods of operating the same are described herein. In various embodiments, an implant for interfacing with a bone structure includes a web structure, including a space truss, configured to interface with human bone tissue. The space truss includes two or more planar truss units having a plurality of struts joined at nodes. Implants are coated with, or have struts formed from, a piezoelectric material to 15 enhance bone growth around and through the implant. 5 TITLE: PIEZOELECTRIC COATED IMPLANTS AND METHODS OF USING PIEZOELECTRIC COATED IMPLANTS TO REPAIR BONE STRUCTURES Various embodiments of implant systems and related apparatus, and methods of operating the same are described herein. In various embodiments, an implant for interfacing with a bone structure includes a web structure, including a space truss, configured to interface with human bone tissue. The space truss includes two or more planar truss units having a plurality of struts 15 joined at nodes. Implants are coated with, or have struts formed from, a piezoelectric material to enhance bone growth around and through the implant. ct : c t

Integrally formed medical devices

Resumen de: AU2025100016A4

INTEGRALLY FORMED MEDICAL DEVICES Abstract Disclosed herein are integrally formed medical devices and methods relating thereto. One embodiment provides an integrally formed patient-specific interbody spinal fusion medical device (1100), wherein the medical device (1100) is integrally formed using an additive manufacturing process, the medical device (1100) including: a body portion (1150) having at least one surface (1115) that is contoured to fit an anatomy of the patient; a graft window (1160) defining an aperture through said body portion (1150), such that said body portion (1150) defines a cage; and an identifier (1190) integrally formed on the device (1100). Se p 25 INTEGRALLY FORMED MEDICAL DEVICES 2025100016 19 2025 Sep Abstract Disclosed herein are integrally formed medical devices and methods relating thereto. One embodiment provides an integrally formed patient-specific interbody spinal fusion medical device (1100), wherein the medical device (1100) is integrally formed using an additive manufacturing process, the medical device (1100) including: a body portion (1150) having at least one surface (1115) that is contoured to fit an anatomy of the patient; a graft window (1160) defining an aperture through said body portion (1150), such that said body portion (1150) defines a cage; and an identifier (1190) integrally formed on the device (1100). INTEGRALLY FORMED MEDICAL DEVICES Abstract - 21/30 - Fig. 12 Se p

ADDITIVES FOR 3D PRINTING POLYMER RESINS

Resumen de: US2025346703A1

The present disclosure provides micelles comprising a plurality of block co-polymers, the micelle comprising (i) a core comprising at least a portion of a poly(alkyl acrylate) block of one or more of the block co-polymers; and (ii) an outer layer comprising at least a portion of a poly(aryl acrylate) block or a poly(aryl methacrylate) block of one or more of the block co-polymers. The present disclosure also includes polymer compositions, polymer films, and devices (e.g., orthodontic equipment) including the same. Methods for making and using micelles, polymer compositions, polymer films, and devices (e.g., orthodontic equipment) are also disclosed. Further provided herein are methods of producing polymer compositions and using the same for the fabrication (e.g., via 3D printing) of medical devices, such as orthodontic appliances.

IMPLANT

Resumen de: AU2024241734A1

This invention relates to an implant (10), including a support arrangement (12) manufactured from a form of a porous material, for receiving and supporting stem cells (14) in a supported condition, for receiving a medium in the form of a neural basal and neural induction medium mixture (20) and the support arrangement (12) being shaped and sized to conform to and be received complementally by an implant zone (16). The implant zone (16) being a space defined by an excised portion of a subject's spinal cord (18). The neural basal and neural induction medium mixture (20) provides nutrients for the development of the stem cells (14) and the growth factors, in form of neurotrophin 3, neurotrophin 4 and brain-derived neurotrophic factor (BDNF) encourage and control development of the stem cells (14), the growth factors typically being constituents of the medium mixture (20).

A METHOD FOR PRODUCING AND USING A COMPLEX FLUID

Resumen de: AU2024311509A1

Disclosed is a method for producing complex fluid of bubbly liquid material that is suitable for being used in 3D printing, the method comprising producing to liquid material primary bubbles (420), and optionally secondary (425) and tertiary bubbles, as a supporting material for printing a 3D object (415) or for using as printing ink, wherein the liquid material comprises at least the primary bubbles.

METHOD FOR MANUFACTURING A HIP IMPLANT, INDIVIDUALIZED HIP IMPLANT

Resumen de: WO2025233409A1

The invention relates to a method for manufacturing a hip implant (20), the method comprising the following: providing a patient information data set (72), which comprises information relating to a shape of a hip bone (10) with an acetabular defect (11), generating a shape data set (76), which comprises information relating to a target shape for a hip implant for the acetabular defect, with the target shape having an individual component (32, 38, 44, 54), the dimensions and/or arrangement of which are characterized by at least one modifiable geometry parameter, and with the generation of the shape data set comprising the definition of the at least one geometry parameter on the basis of the patient information data set, and manufacturing an individualized hip implant on the basis of the shape data set. The invention also relates to an individualized hip implant.

PREPARATION GUIDE FOR A DENTAL PREPARATION

Resumen de: WO2025233189A1

The invention relates to a method for generating a three-dimensional digital guide model (170) of a physical preparation guide (184) for a dental preparation of a patient's jaw. A three-dimensional digital jaw model (100) and a definition of tooth positions (102) is received. The tooth positions (102) comprise one or more target tooth positions for one or more artificial teeth. The three-dimensional digital jaw model (100) is overlaid with a three-dimensional digital corrugated surface (120). The overlaying comprises adjusting a waveform of the corrugation with local minima and maxima (122; 124), such that the local minima (122) are arranged at the positions (102) of the teeth, while the local maxima (124) are arranged between the positions (102) of the teeth. The three-dimensional digital guide model (170) is generated using the three-dimensional digital corrugated surface (120) with the adjusted waveform.

INJECTABLE AND 3D EXTRUSION PRINTABLE HYDROPHILIC SILICONE-BASED HYDROGEL FOR CONTROLLED DRUG RELEASE

Resumen de: WO2025232846A1

The hydrophilic silicone macrochains is arrested into semi-interpenetrating polymer network via in situ photo-gelation assisted 3D microextrusion printing technique. The printed hybrid hydrogel has shown microporous morphology with tunable diffusion behaviour. The flow behaviour of the hydrogel has been tested showing high elastic modulus, low tan δ, high gel strength, and delayed network rupturing behaviour. The uniaxial compression test showed the almost zero permanent set which could promote it as an elastomer mimetic soft biomaterial. Moreover, the drug loading into the hydrogel has been performed which showed hydrophilic silicone dependent non-Fickian anomalous transport. The encapsulated drug stability inside hydrogel matrices also showed no deterioration of the pristine drug molecules even after one month storage. This could be the first hydrodrophilic silicone based soft biomaterial will serve as an excellent controlled drug delivery device.

3D PRINTED GALLIUM SCAFFOLD

Resumen de: US2025345482A1

A biocompatible 3D-printed scaffold is described. The scaffold includes a biocompatible polymer shaped to form a scaffold using 3D printing and a gallium compound. Methods of making 3D-printed scaffolds, and methods of using 3D-printed scaffolds to inhibit bone resorption are also described.

Bioink Compositions and Methods for 3D Printing Of Vascularized Tissue Constructs

Resumen de: US2025345480A1

Compositions and methods for bioprinting a transplantable vascularized tissue construct that allows for direct surgical anastomosis to a host, to achieve immediate blood perfusion with host vasculature for long-term cell survival and function.

Piezoelectric Stents with Self-Powered Anti-Restenosis Properties

Resumen de: US2025345193A1

An electric field-assisted 3D printing system that allows for fast printing of complex and spontaneously polarized ferroelectric structures with high fidelity and superb piezoelectric performance. The system provides the basis for development of a piezoelectric vascular structure that can serve as a stent, providing self-powered electricity to prevent restenosis and biologic growth by producing a low intensity electric field around the stent.

METHOD FOR PROVIDING A 3D-PRINT DATA SET OF A DENTAL MODEL STRUCTURE, COMPUTER PROGRAM PRODUCT, DENTAL MODEL STRUCTURE, MOUNTING PLATE AND DENTAL MODEL SYSTEM

Resumen de: US2025345158A1

The invention relates to a method for providing a 3D-print data set of a dental model structure (100) to be mounted on an articulator (5), comprising:providing an articulator data set of the articulator (5) on which the dental model structure (100) is to be mounted;providing a dental situation data set which represents a dental situation of an upper jaw and/or a lower jaw, the dental situation data set including data to display the dental situation as a virtual representation of the dental situation on a display;selecting at least one distance element (20) from a plurality of different predefined and/or prefabricated distance elements based on the articulator data set and the dental situation data set;generating a connecting structure data set representing at least a virtual connecting structure (15) arranged between the virtual representation of the dental situation and a virtual representation of the at least one selected distance element; andgenerating the 3D-print data set based on the dental situation data set and the connecting structure data set.Furthermore, the invention relates to a corresponding computer program product, a dental model structure, a mounting plate and a dental model system.

INJECTABLE AND 3D EXTRUSION PRINTABLE HYDROPHILIC SILICONE-BASED HYDROGEL FOR CONTROLLED DRUG RELEASE

Resumen de: US2025345272A1

This invention arrests the hydrophilic silicone macrochains into semi-interpenetrating polymer network via in situ photo-gelation assisted 3D microextrusion printing technique. The printed hybrid hydrogel has shown microporous morphology with tunable diffusion behaviour. The flow behaviour of the hydrogel has been tested showing high elastic modulus, low tan δ, high gel strength, and delayed network rupturing behaviour. The uniaxial compression test showed the almost zero permanent set which could promote it as an elastomer mimetic soft biomaterial. Moreover, the drug loading into the hydrogel has been performed which showed hydrophilic silicone dependent non-Fickian anomalous transport. The encapsulated drug stability inside hydrogel matrices also showed no deterioration of the pristine drug molecules even after one month storage. This could be the first hydrodrophilic silicone based soft biomaterial will serve as an excellent controlled drug delivery device.

THERAPEUTIC ULTRASONICATION SYSTEM FOR OPENING BLOOD-BRAIN BARRIER AND ULTRASONIC WAVE CONTROL METHOD OF THERAPEUTIC ULTRASONICATION SYSTEM FOR OPENING BLOOD-BRAIN BARRIER

Resumen de: EP4647119A1

The present invention relates to an ultrasonic wave control method of a therapeutic sonication system for opening a blood-brain barrier, the method comprising the steps of: setting output conditions for outputting ultrasonic energy to an acoustic cavitation-inducing substance administered to a subject; outputting ultrasonic energy corresponding to the output conditions to the subject; receiving an acoustic signal resulting from acoustic cavitation induced by the acoustic cavitation-inducing substance; analyzing the acoustic signal to determine whether preset control conditions have been satisfied; and, depending on whether the preset control conditions have been satisfied, outputting ultrasonic energy after adjusting at least one of a duty cycle, the number of stimulation pulses per a predetermined time unit, pulse repetition frequency per a predetermined time unit, and applied voltage, among the output conditions of ultrasonic energy, or stopping the outputting of ultrasonic energy.

一种用于UV3D打印齿科修复模型树脂及其制备方法

Resumen de: CN120923697A

本发明公开了一种用于UV3D打印齿科修复模型树脂及其制备方法，属于环氧树脂材料技术领域，包括核心功能单体合成、活性稀释剂‑环氧树脂共混、微波辅助纳米二氧化硅原位生成、超声辅助MOF负载引发剂的制备、紫外光‑等离子体复合表层处理、变频近红外快速固化得到用于UV3D打印齿科修复模型树脂。本发明通过核心功能单体的创新合成、多组分协同共混以及特殊的制备工艺，有效解决了传统齿科3D打印光固树脂存在的性能缺陷，大幅提升了材料的力学性能、固化稳定性与打印精度，为齿科修复模型的高精度、高性能3D打印提供了可靠的技术方案。

一种植物纤维改性3D打印材料及其制备方法

Resumen de: CN120923991A

本申请涉及3D打印材料技术领域，更具体地说，涉及一种植物纤维改性3D打印材料及其制备方法，由以下重量份的原料制备得到：聚乳酸、植物纤维粉末、聚琥珀酸丁二醇酯、多孔球形碳酸钙、乙烯‑丙烯酸共聚物、海藻酸钠、醋酸纤维素、植物型纳米晶、交联剂、润滑剂、所述植物型纳米晶由纤维素纳米晶、硅纳米晶和羟基磷灰石纳米晶组成，通过采用上述配方使材料在喷嘴中更顺畅地流动，从而有效避免熔融或光固化喷嘴在打印细小线径时出现的极易堵塞、空打或缠线等问题，降低批次报废率，提高生产效率。同时在后拉伸细化过程中，即使在较大范围内调整拉伸参数，也不易出现过拉易断、欠拉强度不足的情况，从而保证了3D打印手术缝线的质量和性能。

一种基于3D打印的可降解引流支架

Resumen de: CN120918853A

本发明涉及引流支架技术领域，公开了一种基于3D打印的可降解引流支架，包括引流管以及操作台，引流管包括第一管体和第二管体，第一管体和第二管体的侧壁上均开设有多个圆孔，第一管体和第二管体间设有连接组件；第一管体的端部处设有限位件；操作台的上端面设有升降板，升降板的上端面安装有操作杆，操作杆的下端面安装有操作板，操作板的上端面安装有第一卡杆，第一卡杆的下端面安装有第一卡块，操作台的上端面设有升降组件。通过上述构造，使得第一管体、第二管体、波纹管以及螺纹部均通过3D打印机制成，其材料通过可降解的材质制成，使得引流支架本体能够自然溶解在患者体内，避免患者需要进行二次手术的情况。

一种用于超声打印的生物黏附剂及其制备与应用

Resumen de: CN120919387A

本申请属于生物材料及超声打印技术领域，具体公开了一种用于超声打印的生物黏附剂及其制备与应用。所述生物黏附剂包括热敏性主体材料和化学黏附组分，所述热敏性主体材料包括羟丁基壳聚糖，所述化学黏附组分包括聚丙烯酸‑N‑羟基琥珀酰亚胺酯。所述生物黏附剂具有优异的超声响应性、成形性与生物黏附性能，可在无接触、精确操控的超声打印系统中实现定向沉积、原位固化和组织表面粘附，适用于组织修复、微创医学、生物器件构建、药物递送界面打印等多种生物医学场景。

一种3D打印仿骨生物支架及其制备方法

Resumen de: CN120919420A

本发明涉及骨修复领域，公开了一种3D打印仿骨生物支架及其制备方法，首先将溴化铵加入去离子水和无水乙醇的混合物中，得到溴化铵溶液；依次加入氨溶液、正硅酸乙酯、磷酸三乙酯、硝酸钙和钒酸钠，并持续搅拌后离心，收集沉淀物；洗涤、陈化后，加热后降温，研磨粉碎后筛分，得到V‑MBG粉末；配置TA溶液和V‑MBG溶液，混合后放入，冷冻干燥得到TA@V‑MBG粉末；制备PLGA的三氯甲烷溶液，加入V‑MBG粉末充分搅拌后，抽干三氯甲烷溶液，得到固体浆料；打印出内层支架和空心管外层支架，得到仿骨生物支架，浸泡在TA溶液中，得到PLGA/TA@V‑MBG复合支架；本发明解决了现有技术中骨修复效果不好、骨样细胞增殖与分化效果不好，无法实现治疗骨肿瘤导致的骨缺损修复的问题。

一种3D打印内侧髌股韧带重建股骨隧道定位器及其制备装置

Nº publicación: CN223529474U 11/11/2025

Solicitante:

昆明医科大学第一附属医院

Resumen de: CN223529474U

本申请属于医疗器械技术领域，公开一种3D打印内侧髌股韧带重建股骨隧道定位器及其制备装置，其中，3D打印内侧髌股韧带重建股骨隧道定位器包括第一圆柱体、第二圆柱体、适骨壳和操作杆；其中，第二圆柱体的直径大于第一圆柱体的直径，第二圆柱体的长度小于第一圆柱体的长度，第二圆柱体套接于第一圆柱体的外侧，适骨壳套接于第二圆柱体的外侧，操作杆与第二圆柱体的外侧固定连接。本申请通过第一圆柱体可以穿过标准手术切口，第二圆柱体套接于第一圆柱体，以安装操作杆和适骨壳，其中操作杆方便对定位器的操作，通过适骨壳可牢固地贴合到股骨后髁沟，从而实现与股骨的完美贴合，保证定位的准确性。