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TUMOR MODEL AND PROCESS OF PREPARATION THEREOF

Resumen de: EP4650437A1

The present invention refers to a process for preparing a three-dimensional tumor model having a core-shell structure using bioprinting techniques leading to tumor models capable of better reproducing the physiopathological complexity of real tumors, mimicking the tumor microenvironment and the original tumor tissue extracellular matrix. The process is based on the use of dECM (decellularized extracellular matrix) bioinks but with the particularity that no exogenous biopolymers that modify the rheological properties to improve printability are needed. The absence of rheological modifiers in the bioinks avoids any kind of physical or biochemical interference in the tumor model so obtained.

METHODS FOR GENERATING SUPPORT STRUCTURES FOR ADDITIVELY MANUFACTURED OBJECTS

Resumen de: US2024227300A1

Methods and systems for generating support structures for additively manufactured objects are described herein. In some embodiments, a method includes receiving a digital representation of a dental appliance configured to implement a treatment stage of a treatment plan for a patient's teeth. The method can include generating a support structure arrangement configured to support the dental appliance during an additive manufacturing process. The support structure arrangement can be generated using a machine learning model. The machine learning model can be trained on a training data set including appliance data representing geometries of a plurality of dental appliances, support structure data representing geometries of a plurality of support structure arrangements, and outcome data representing outcomes of the additive manufacturing process for the plurality of dental appliances with the respective support structure arrangements.

BIOMETRIC MODEL OF FIBROSIS

Resumen de: WO2024150259A1

Method for producing a biomimetic model of fibrosis which comprises the steps of: associating at least one cell type with at least one bio-ink containing collagen, obtaining a first compound; depositing said first compound in a culture medium obtaining a first deposited compound; keeping said first deposited compound in said culture medium for a period of time longer than 1 day, preferably comprised between 2 and 5 days; adding a profibrotic factor TGF-beta (TGFP) to said first deposited compound, obtaining a second added compound; keeping said second added compound in said culture medium for an additional period of time longer than 1 day, preferably comprised between 2 and 7 days; a biomimetic model of fibrosis which comprises at least one cell type associated with at least one bio-ink containing type I collagen and at least one profibrotic factor TGFβ is added to said bio-ink.

ORAL MODEL DATA MATCHING METHOD AND DEVICE

Resumen de: US2023076682A1

The present disclosure relates to a method and device for matching oral model data that can provide matching points to a user to match oral model data and computerized tomography (CT) data even for edentulous patients. In this way, convenience is increased and matched data can be effectively generated even for edentulous patients for whom matching has been difficult conventionally.

BONE STABILIZING IMPLANTS ACROSS SI JOINTS

Resumen de: AU2025230762A1

Abstract The invention relates to a threaded bone implant, comprising: an elongate body extending from a proximal end of the bone implant to a distal end of the bone implant, the elongate body including an inner shank, one or more threads, each of which extend radially from the inner shank and extend along at least a portion of a length of the elongate body, a porous network of interconnected struts extending radially from the inner shank and disposed and extending axially between the one or more threads, the inner shank, the one or more threads, and the porous network of interconnected struts being formed together with an additive manufacturing process such that the inner shank, the one or more threads, and the porous network of interconnected struts are integral, and wherein the porous network of interconnected struts has a greater surface area in a central region of the elongate body than in a distal region of the elongate body, wherein the central region includes a midpoint of the length of the elongate body. Abstract The invention relates to a threaded bone implant, comprising: an elongate body extending from a proximal end of the bone implant to a distal end of the bone implant, the elongate body including an inner shank, one or more threads, each of which extend radially from the inner shank and extend along at least a portion of a length of the elongate body, a porous network of interconnected struts extending radially from the inner shank and disposed and extending a

一种混合支持式多角度可视化自适应正畸种植支抗导板的制备方法

Resumen de: CN120963041A

本发明公开了一种混合支持式多角度可视化自适应正畸种植支抗导板的制备方法，包括以下步骤：S1、数据采集；S2、数据拟合；S3、设计正畸种植钉；S4、设计混合支持式多角度可视化自适应正畸种植导板：获得牙冠‑牙根‑粘膜模型，设计牙齿‑粘膜‑咬合三重混合支持式多角度可视化自适应种植导板，进一步生成混合支持式多角度可视化自适应正畸种植导板STL文件；S5、3D打印；S6、制成成品：将打印后的导板去除支撑杆、打磨抛光，消毒后，制作完成。本发明使导板抗旋位移力提升，术中无需额外器械固定；可视化轨道与头端开口全程暴露钻头与钉尖，方便导板脱位，医生可在直视下避开牙根、上颌窦及神经管，牙根损伤率降低。

一种非均匀融合结构多孔陶瓷及其制备方法与应用

Resumen de: CN120965363A

本申请公开了一种非均匀融合结构多孔陶瓷的制备方法，包括：步骤一、构造融合函数，确定融合函数的参数；步骤二、制备蜡型负模板；步骤三、配置陶瓷浆料；步骤四、浸渍、冷冻；步骤五、低压干燥；步骤六、烧结，获得TPMS结构多孔陶瓷。本申请还包括一种非均匀融合结构多孔陶瓷。本申请还包括非均匀融合结构多孔陶瓷在仿生骨支架领域中的应用。本申请融合G形函数和TPMS函数构造融合函数，实现多种孔型的非均匀融合；采用蜡质负模板冷冻铸造，间接成型的方式，保留了复杂结构的设计自由度的同时，解决了直接3D打印多孔陶瓷时面临的分辨率限制、收缩变形和支撑困难等问题，使用效果好。

用于弧形3D物品的旋转立体光刻

Resumen de: US2024351282A1

A three-dimensional (3D) printing system is configured to manufacture a plurality of arcuate 3D articles. The 3D printing system includes a build vessel, at least one build assembly, a light engine, and a controller. The at least one build assembly individually includes an axle, a build plate, and a motorized gear assembly. The motorized gear assembly is coupled to the axle and configured to rotationally position the axle about an axis of rotation. The light engine is located above the build vessel. The controller is configured to operate the motorized gear assembly to incrementally rotate the build plates about the axis of rotation between a plurality of stop positions. The controller is configured to operate the light engine at individual stop positions to selectively irradiate the photocurable liquid within a plurality of spatially separated build planes that are individually above one of the plurality of build plates.

一种基于中医治疗的护心灸制备工艺及其使用方法

Resumen de: CN120960041A

本发明公开了一种基于中医治疗的护心灸制备工艺及其使用方法，具体涉及护心灸技术领域，包括步骤如下：S1、药物配方研制，S2、灸具设计，使用方法包括步骤如下：S1、精准穴位定位，S2、灸疗方案制定，S3、优化灸疗过程。本发明通过现代技术优化药物配方与剂型提升疗效，创新灸具设计保障安全舒适，借助先进手段实现精准个性化治疗，综合管理系统协同各模块为优化治疗和工艺改进提供支持，带来更优质中医治疗体验。

一种基于3D打印的功能化胶原支架及其在跟腱修复与异位骨化预防中的应用

Resumen de: CN120960505A

本发明涉及生物医学工程与组织再生技术领域，具体公开了一种基于3D打印的功能化胶原支架及其在跟腱修复与异位骨化预防中的应用，所述支架是结合聚乳酸‑羟基乙酸共聚物与Ⅰ型胶原的复合基材，集成经BMP抑制剂预处理及胶原结合肽修饰的CD26+肌腱干细胞外泌体，形成的3D打印支架。本发明通过集成BMP信号抑制与胶原靶向缓释双功能策略，结合3D打印技术制备的复合支架，显著解决了现有肌腱修复技术中再生效果不足与异位骨化(HO)高发的难题。

一种利用低温3D打印技术制备多孔丝素蛋白骨水泥支架的方法

Resumen de: CN120960511A

本发明公开了一种利用低温3D打印技术制备多孔丝素蛋白骨水泥支架的方法，属于生物医用材料技术领域。该方法包括采用同轴喷头，将包含丝素蛋白、海藻酸盐及生物活性陶瓷的壳层墨水与牺牲性芯层墨水，共同挤出至温度呈梯度分布的低温平台；将形成的冷冻核‑壳结构丝束进行冷冻干燥后，浸入钙离子溶液中，以同步实现牺牲性芯层的洗脱移除来构筑中孔，以及海藻酸盐的离子交联来增强结构；最后通过温和的乙醇蒸汽处理完成最终固化。本发明可构筑兼具大孔、中孔及梯度微孔的三级仿生孔道结构，且制备的支架具有优异的结构可控性和力学性能。

一种具有光热介导形状记忆和热疗功能的大豆油基复合骨支架及其制备方法

Resumen de: CN120960519A

本发明公开了一种具有光热介导形状记忆和热疗功能的大豆油基复合骨支架及其制备方法。该方法以生物基丙烯酸化环氧大豆油和聚乙二醇二丙烯酸酯为复合基体，将天然黑色素纳米颗粒作为功能组分掺入其中制得复合光敏树脂，最终通过数字光处理3D打印技术制备成多孔支架。在近红外光的照射下，复合支架表现出可控的和高效的光热响应行为，能够通过调整天然黑色素纳米颗粒的负载量和照射条件来达到目标的稳态温度。一方面，光热效应能够触发形状记忆恢复，以实现对不规则骨缺损的微创植入与形状自适应填充。另一方面，复合支架表现出对人骨肉瘤细胞高效的光热抑制效应（抑制率超过90%）。此外，复合支架表现出增强的体外生物矿化能力。本发明为设计和制备多功能生物基3D打印骨支架以应对复杂骨缺损的挑战提供了一个有前景的解决方案。

一种带卫生消毒功能的3D打印一次性碗盘装置及方法

Resumen de: CN120963029A

本发明公开了一种带卫生消毒功能的3D打印一次性碗盘装置及方法，旨在解决日常三餐洗碗的问题，同时确保餐具的卫生安全性。该装置包括3D打印模块、材料供给系统、成型平台、消毒模块及控制系统；所述方法通过预设模型选择、快速3D打印成型、紫外线+热风双重消毒的流程，实现一次性碗盘的即时制造与卫生保障。本发明采用食品级可降解材料，打印时间短（1‑3分钟/个），消毒后可直接使用，用完即弃且环保可降解，适用于家用、办公及户外场景，既省去洗碗步骤，又通过内置消毒环节提升餐具卫生等级。

一种用于眼部疾病治疗的跨巩膜持续给药装置

Resumen de: CN223555063U

本实用新型公开一种用于眼部疾病治疗的跨巩膜持续给药装置，包括圆弧体、翼型固定板和固定带；圆弧体的底面开设有凹槽；两翼型固定板对称设置在圆弧体的两侧；两翼型固定板分别纳入外直肌的肌腹下和下直肌的肌腹下；若干固定带固接在圆弧体的底面上，固定带与凹槽的内壁之间设有间隙，间隙用于存放药膜；两翼型固定板远离圆弧体的一端设有间隔，圆弧体和两翼型固定板整体呈C字形。本实用新型能良好贴合眼球、减少对眼球的压迫，从而不影响眼球自由转动，提高佩戴舒适感及药物生物利用度，减少药物成分外渗于角结膜面及筋膜组织，避免药物通过结膜血管及淋巴管进步血压循环，降低全身副作用的风险，减少毒性及不良反应的发生。

一种腰椎压缩性骨折俯卧过伸复位手术垫板制备方法

Resumen de: CN120959957A

本发明属于医疗器械技术领域，涉及一种腰椎压缩性骨折俯卧过伸复位手术垫板的制备方法，包括以下步骤：收集患者胸腰椎影像学资料(X线片和CT图像)；通过三维重建软件生成腰椎三维立体模型；分析骨折椎体解剖学关系；利用Surgimap软件进行3D过伸位复位模拟，计算过伸角度(β‑α)，生成胸部垫子和髂部垫子的三维数字化模型；采用3D打印技术制作手术垫板，表面覆盖泡沫或硅胶软垫。本方法基于患者个性化数据，精准设计垫板参数，使腰椎稳定于过伸位，显著提高复位效果，降低手术难度和并发症。适用于PVP、PKP等手术，制作成本低，易推广，改善患者预后。

一种可降解材料及其制备方法和用途

Resumen de: CN120960503A

本发明公开了一种可降解材料及其制备方法和用途。所述可降解材料,包括脂肪族聚酯和/或改性脂肪族聚酯，所述可降解材料为薄片状，其厚度为0.1‑8mm，优选为2‑5mm。本发明制备的可降解(面部填充塑形)材料厚度可控并可根据实际需求加工成不同形状，质地柔软，形态轻薄，减少了因重力引起的移位和骨吸收；厚度仅0.1‑8mm厚，填充时异物感不明显，植入手术简便，耗时短；具有良好的组织整合性，术后稳固不易移位，不会形成凸起和肉芽，并且不会对人体产生危害。

AUTOMATIC DETECTION OF DENTAL INDICATIONS

Resumen de: JP2023153040A

To provide a method of identifying an indication of a digital dental object based on a geometric shape so that a suitable manufacturing method can be selected.SOLUTION: A dental recognition method using a manufacturing device (200) is provided, comprising providing a digital dental object in a coordinate system describing a shape of a dental object to be manufactured (S101), and automatically assigning the digital dental object to a predetermined class based on the shape using a self-learning algorithm (S102).SELECTED DRAWING: Figure 6

3D-gedruckte Orthese und Herstellungsverfahren hierfür

Resumen de: AT528258A1

Die Erfindung betrifft ein Verfahren zum Herstellen einer Orthese (21), gekennzeichnet durch die Schritte: - Bereitstellen eines Multiachsen 3D-Druckers zum Drucken einer Endlosfaser (30), - Drucken eines ersten Stützabschnitts (22) der Orthese (21), wobei die Endlosfaser (30) in gekrümmten Flächen (F1, F2) und/oder in einem Winkel zueinander angeordneten ebenen Flächen gedruckt wird. Die Erfindung betrifft weiters eine mit diesem Verfahren hergestellte Orthese und ein computerimplementiertes Verfahren zur Ermittlung von Ansteuerbefehlen für einen 3D- Drucker zum 3D-Drucken dieser Orthese.

多层仿生支架及其制备方法

Resumen de: CN120941625A

本发明公开了一种多层仿生支架及其制备方法。所述多层仿生支架的制备方法包括以下步骤：S1、对牺牲材料进行逐层3D打印，连续打印n层，得到网格状多孔内模具；S2、在所述网格状多孔模板内灌注仿生水凝胶前体溶液，然后进行光固化交联，形成牺牲材料‑水凝胶复合体；S3、重复步骤S1和S2，形成多层牺牲材料‑水凝胶复合体；S4、采用溶剂溶解法对所述多层牺牲材料‑水凝胶复合体进行内脱模处理，得到多层仿生支架。该制备方法基于内脱模技术实现分层仿生设计，确保了不同仿生层的水凝胶各自独立存在，避免了一次性灌注时相邻层之间仿生材料的混合和扩散问题，精准实现不同仿生层的设计，同时也确保有效固化。

嵌段共聚体及包括其的聚氨酯丙烯酸酯、树脂组合物、3D打印树脂材料、牙套

Resumen de: CN120944116A

本发明提供一种嵌段共聚体，嵌段共聚体包括ABA嵌段序列，ABA嵌段序列包括A嵌段序和B嵌段，A嵌段为可与聚氨酯形成氢键的聚酯嵌段，B嵌段为聚醚嵌段或聚硅氧烷嵌段中的至少一种，在B嵌段的两端连接A嵌段构成ABA嵌段序列。在应用上述嵌段共聚体和聚氨酯合成的聚合物中，嵌段共聚体促进了聚氨酯形成均匀分布的小硬域，避免材料应力集中，使得聚合物能够兼备良好的力学强度以及良好的抗应力松弛性能。

基于单元设计的可局部微调的脊柱侧弯矫形器及制造方法

Resumen de: CN120938696A

本发明属于矫形设备技术领域，涉及一种个性化脊柱侧弯矫形器设计及制造方法，该设计通过局部刚度的动态调整来适应矫形的不同阶段对矫形器局部刚度的需求改变，解决了传统矫形器单一模式、舒适性差、调节困难、无法适应动态康复需求的难题。该个性化脊柱侧弯矫形器主体由多个基本单元组成，通过一个或多个基本单元的局部形变，实现局部区域刚度的提升和降低进而实现矫形器整体的矫形功能性调整。本发明允许矫正过程中患者骨骼形态随矫正过程的不断改变而进行实时修正矫形策略，无需重新取模和制备新的矫形器，能够实现即时的局部个性化的矫正，相较于传统矫形器，极大的提升了矫形器的穿戴舒适性。

骨インプラントのための骨採取デバイス

Resumen de: CN120201970A

Provided herein are medical devices and methods for treating bone fractures. The medical device includes a body, a stent within the body, and means for concentrating bone growth throughout the body. The device is designed to minimize shear stresses on the distal tip and to distribute micromotion to promote bone ingrowth. The stent may include a three-periodic minimal curved surface (TPMS) having a cubic repeating pattern defining walls within the stent, and the TPMS may be helically wound about a central axis of the device. The device may also contain a biological agent and contain an autologous product. In some embodiments, the medical device is a bone screw or pedicle screw designed to reduce common problems such as screw loosening, screw disengagement, and shaft breakage. The method of treatment involves implanting the medical device into a bone of a patient to aid in fracture healing.

低弾性率物品の製造方法

Resumen de: AU2023375298A1

A method of manufacturing a three-dimensional (3D) article includes operating a print engine to fabricate a composite structure including the 3D article coupled to a support structure, removing the composite structure from the fluid tank, and peeling the inside surface of the sheath away from the outer surface of the article, peeling progressively breaks the plurality of strands. The support structure includes a conformal sheath having an inside surface that follows the outer surface of the 3D article with a gap between the inside surface of the sheath and the outer surface of the article, and a plurality of strands that span the gap and individually have opposed ends that are coupled to the inside surface of the sheath and the outer surface of the article to maintain the gap, the gap filled with the photocurable liquid ink.

骨インプラント用のルーメンを有する装置

Resumen de: CN120187366A

Provided herein are medical devices and methods for treating bone fractures. The medical device includes a body having a proximal end and a distal tip, the body housing a stent having porous structures distributed in a proximal grid and a distal grid. The device includes an upper lumen in fluid communication with a first opening at the proximal end, and a lower lumen in fluid communication with a second opening at the proximal end. The device is configured to support independent delivery of cement and cells to the mesh. In some embodiments, the device is a bone screw having a thickened head-neck junction designed to reduce the likelihood of rod breakage during installation. The method includes implanting the device into a bone of a patient, thereby providing an innovative method for fracture treatment.

PREPARATION GUIDE FOR A DENTAL PREPARATION

Nº publicación: US2025345154A1 13/11/2025

Solicitante:

EXOCAD GMBH [DE]
EXOCAD GMBH